JP5586321B2 - Cleaning / preserving solution for oxygen permeable hard contact lenses - Google Patents

Description

  The present invention relates to an oxygen permeable hard contact lens cleaning / preserving solution, and in particular, an oxygen permeable hard contact lens cleaning solution having improved lens compatibility, rinsing properties, lipid cleaning power, feeling of use, and antibacterial properties, and storage. Liquid and washing preservation solution.

  Conventionally, unlike a soft contact lens, a hard contact lens has been provided to users as a product with a product standard close to custom-made, and therefore, the lens price has been high. Therefore, once a hard contact lens is purchased, it is generally used repeatedly for several years. Therefore, in order to enable such long-term use, a hard contact lens is used. These are subjected to regular cleaning treatment and stored in a preservation solution when not in use. Even in such a cleaning / preserving solution for cleaning / preserving, in order to keep the hard contact lens in a clean state for several years, a strong surfactant is blended at a certain high concentration. In order to increase the detergency, it has been generally adopted, and a method for removing lens dirt by incorporating a protein removing enzyme at the same time is also adopted.

  On the other hand, in order to improve the performance of hard contact lenses, hard contact lenses having oxygen permeability have been developed. However, in order to realize such oxygen permeability, in the polymer material constituting the lens, In this case, silicon-based components are incorporated by a method such as copolymerization and introduction of a silicon-containing monomer. For this reason, when the lens is stored in a storage solution due to the influence of such silicon-containing components. There was a tendency for the change in the standard of this lens to be larger than that of conventional hard contact lenses. In particular, among the oxygen permeable hard contact lenses, those with a high lens power show remarkable changes in the standard of the lens, and thus maintain compatibility with such oxygen permeable hard contact lenses. There is a need for cleaners that can be used.

  In addition, since the components in the cleaning solution that affect the change in specifications of such hard contact lenses are mainly surfactants, if the concentration of the surfactant in such cleaning solutions is simply reduced, lens compatibility will be reduced. At the same time, the detergency decreases, the feeling of use deteriorates, and the antibacterial properties also decrease. On the other hand, if a surfactant is included in the cleaning solution at a high concentration as in the past, there is no problem with the cleaning power, feeling of use, and antibacterial properties, but the lens compatibility is reduced as described above. In addition to this, the toxicity due to the adsorption of the surfactant to the lens surface and the high concentration of the surfactant when the lens is rinsed are washed away. Therefore, the problem that the amount of necessary cleaning water inevitably increases is also caused.

  By the way, in JP-A-6-73395, it has an excellent detergency against dirt adhering to a contact lens, has extremely low irritation to eyes and skin, etc., and is damaged to the contact lens. As a detergent composition that does not give a surfactant, one or more polyvalent metal salts of an anionic surfactant and one or more amphoteric surfactants are contained in a predetermined ratio, and What adjusted pH to 5-8 is clarified. However, as shown in the examples, the concentrations of anionic surfactant and amphoteric surfactant are both used at a ratio of 1% by weight or more. Is inherently problematic, and thereby reduces lens compatibility. In addition, since an anionic surfactant is used as a polyvalent metal salt, the polyvalent metal becomes a binding component between the lens material and a dirt component such as protein, and the lens surface. Further, there is a problem in that it becomes difficult to use as a contact lens because dirt adheres to the lens surface over time due to long-term use.

  In JP-A-2000-347145, dirt adhered to a contact lens is washed, and further, hydrophilicity is imparted to the surface of the contact lens to prevent the dirt from re-adhering and to improve the feeling of wearing the contact lens. In order to improve, a contact lens solution containing a water-soluble cationized polymer and a surfactant is proposed, in which an anionic surfactant, an amphoteric surfactant and a nonionic surfactant are used as the surfactant. It is said that at least one selected from active agents can be used, and in the examples, examples in which an anionic surfactant and an amphoteric surfactant are used in combination are also clarified. . However, there is no clarification as to what kind of anionic surfactant or amphoteric surfactant can be used, and while maintaining the lipid detergency and feeling of use. What kind of anionic surfactants and amphoteric surfactants should be combined in order to impart antibacterial properties and to solve the problem of lens standard changes caused by surfactants, etc. It has not been revealed.

JP-A-6-73395 JP 2000-347145 A

  Here, the present invention has been made in the background of such circumstances, and the problem to be solved is to impart effective antibacterial properties while maintaining excellent lipid detergency and usability. Furthermore, a cleaning / preserving solution for oxygen-permeable hard contact lenses that can advantageously eliminate the problem of change in lens specifications due to the surfactant and the problem of rinsing and toxicity due to the surfactant remaining in the lens. Is to provide.

  And in order to solve the above-mentioned problem or the problem grasped from the description of the entire specification, the present invention can be suitably implemented in various aspects as listed below. Each aspect described in the above can be employed in any combination. It should be noted that the aspects and technical features of the present invention are not limited to those described below, and can be recognized based on the description of the entire specification and the inventive idea disclosed therein. Should be understood.

(1) A component composed of at least one selected from sodium salts of sulfonic acid type and sulfate ester type anionic surfactants is contained in a range of 0.2 wt% or more and less than 1 wt%. And B component composed of at least one selected from amphoteric surfactants consisting of lauryldimethylaminoacetic acid betaine, lauryldimethylamine oxide and laurylhydroxysulfobetaine , 0.1 wt% or more, 0.8 wt% The oxygen-permeable hard contact lens , which is contained in the following range , and wherein the A component and the B component are contained in a weight ratio of 2: 1 to 6: 1 wash Kiyoshiho exist solution.
( 2 ) The oxygen according to the aspect (1 ), wherein the component A is composed of at least one selected from α-olefin sulfonate Na, lauryl sulfate Na, lauryl sulfoacetate Na and POE lauryl ether sulfate Na. permeable hard contact lens washing Kiyoshiho exist solution.
(3) the manner of a chelating agent, further comprising (1) or (2) an oxygen permeable hard contact lens washing Kiyoshiho presence liquid according to.
( 4 ) The oxygen-permeable hard contact lens washes according to the above aspect ( 3 ), wherein the chelating agent is selected from ethylenediaminetetraacetic acid and salts thereof, nitrilotriacetic acid and salts thereof, hydroxyethanediphosphonic acid and salts thereof. Kiyoshiho exist solution.
(5) a thickener, and further the embodiments containing (1) through an oxygen permeable hard contact lens washing Kiyoshiho presence liquid according to any one of (4).
(6) said thickening agent is cellulose derivatives, guar gum derivatives, oxygen permeability hard contact lens washing Kiyoshiho presence liquid according to the embodiment selected from PVP and PVA (5).
(7) wetting agents, further the embodiments containing (1) through an oxygen permeable hard contact lens washing Kiyoshiho presence liquid according to any one of (6).
(8) the wetting agent, the oxygen permeability hard contact lens washing Kiyoshiho presence liquid according to the embodiment is a polyhydric alcohol (7).
(9) The Dk value of washing or conserved oxygen permeability hard contact lenses, the aspect is 60 or more (1) to wash oxygen permeable hard contact lens according to any one of (8) Kiyoshi save liquid.
(10) The Dk value of washing or conserved oxygen permeability hard contact lenses, the aspect 120 or more (1) to (9) an oxygen-permeable hard contact lens washing according to any one of Kiyoshi save liquid.
(11) A component composed of at least one selected from sodium salts of sulfonic acid type and sulfuric acid ester type anionic surfactants is contained in the range of 0.2 wt% or more and less than 1 wt%. And B component composed of at least one selected from amphoteric surfactants consisting of lauryldimethylaminoacetic acid betaine, lauryldimethylamine oxide and laurylhydroxysulfobetaine, 0.1 wt% or more, 0.8 wt% The oxygen-permeable hard contact lens, which is contained in the following range, and wherein the A component and the B component are contained in a weight ratio of 2: 1 to 6: 1 Cleaning liquid.
(12) A component composed of at least one selected from sodium salts of sulfonic acid type and sulfuric acid ester type anionic surfactants is contained in the range of 0.2 wt% or more and less than 1 wt%. And B component composed of at least one selected from amphoteric surfactants consisting of lauryldimethylaminoacetic acid betaine, lauryldimethylamine oxide and laurylhydroxysulfobetaine, 0.1 wt% or more, 0.8 wt% The oxygen-permeable hard contact lens, which is contained in the following range, and wherein the A component and the B component are contained in a weight ratio of 2: 1 to 6: 1 Stock solution.

  Thus, in the present invention, as a cleaning / preservation liquid used for an oxygen permeable hard contact lens, a specific anionic surfactant having excellent usability and rinsing properties and a specific antibacterial property By containing amphoteric surfactant in combination at a low concentration, it was possible to impart effective antibacterial properties while maintaining excellent lipid cleaning power and usability during scrubbing. Eliminates the problem of lens standard changes caused by surfactants and improves rinsing properties, thereby advantageously eliminating the problem of toxicity due to surfactant remaining in the lens as well as saving tap water. It became possible.

  By the way, the oxygen permeable hard contact lens targeted in the present invention is generally a hard contact lens whose lens material has a property of diffusing oxygen (gas), and has been conventionally used as an RGP contact lens. Various known hard contact lenses will be targeted. Such oxygen-permeable hard contact lenses include, for example, silicon-containing (meth) acrylate monomers, polysiloxane macromonomers, silicon-containing styrene as disclosed in Japanese Patent No. 4451011. It is formed from a polymer material obtained by using a silicon-containing component or the like as a copolymer component, such as a system monomer. In particular, among such oxygen-permeable hard contact lenses, in the present invention, the oxygen permeability coefficient (Dk value by the electrode method) is advantageously 60 or more, more preferably 120 or more. Oxygen permeable hard contact lenses will be targeted.

  The cleaning / preserving solution according to the present invention in which such an oxygen-permeable hard contact lens is cleaned or stored is composed of a component A comprising a specific anionic surfactant and a specific amphoteric surfactant. The two components are generally contained in a predetermined liquid medium, and the liquid medium used therein is tap water or purified water. In addition to water itself, such as water and distilled water, any water-based solution can be used as long as it is an aqueous medium that is highly safe to the living body and sufficiently ophthalmically acceptable. It is possible to use.

Further, the specific anionic surfactant contained in the cleaning / preserving solution according to the present invention is a sodium salt of a sulfonic acid type anionic surfactant and a sodium salt of a sulfate ester type anionic surfactant. The component A is composed of at least one selected from them. As the sodium (Na) salts of these sulfonic acid type and sulfate ester type anionic surfactants, various known ones are appropriately selected. Specifically, as the sulfonic acid type, Can be mentioned α-olefin sulfonate Na, alkylbenzene sulfonate Na, alkylsulfoacetate Na such as Naurylsulfoacetate, and the like, and as the sulfate ester type, alkyl sulfate Na such as lauryl sulfate Na, Examples thereof include polyoxyethylene alkyl ether sulfate Na such as POE (polyoxyethylene) lauryl ether sulfate Na, polyoxyethylene alkylphenyl ether sulfate Na and the like. And such A component will be made to contain in the range of 0.2 weight% (w / v%, the following is same) or more and less than 1 weight% in washing | cleaning / preservation liquid in a total amount. . If this content is too low, the object of the present invention will not be sufficiently achieved. On the other hand, if the content is too high, the compatibility of the lens will be deteriorated and it will be difficult to improve the rinsing performance. The problem such as becoming will arise.

  Furthermore, specific amphoteric surfactants, which are B components that exhibit the excellent effects of the present invention in combination with the A component consisting of the sodium salt of the specific anionic surfactant, are lauryldimethylaminoacetic acid betaine, lauryl Consists of at least one selected from alkylbetaine types such as hydroxysulfobetaine and amine oxide type amphoteric surfactants such as lauryldimethylamine oxide, dihydroxyethyl laurylamine oxide, polyoxyethylene coconut oil alkyldimethylamine oxide Will be. Such a component B is contained in the cleaning / preserving solution at a concentration of 0.1 wt% or more and 0.8 wt% or less. If the content of the B component is too small, the object of the present invention will not be achieved sufficiently, and if the content is too large, problems such as a decrease in lens compatibility will occur. Will come to be.

In the present invention, the Na salt of the specific anionic surfactant and the specific amphoteric surfactant described above are preferably contained in a weight ratio of 2: 1 to 6: 1. As a result, the features of the present invention can be better exhibited. In addition, if the use ratio of the Na salt of the anionic surfactant becomes too low, it becomes difficult to achieve a more effective improvement in usability and ease of use, while the use ratio of the amphoteric surfactant becomes low. If too much, the antibacterial improvement effect may be reduced.

  The oxygen permeable hard contact lens cleaning / preserving solution according to the present invention includes at least one sodium salt of a specific anionic surfactant as described above (component A) and at least one specific amphoteric surfactant ( In addition to these surfactants, a nonionic surfactant can be further added to improve properties such as detergency. Such a nonionic surfactant is generally advantageous at a concentration of about 0.001 to 5% by weight, preferably about 0.005 to 2% by weight, more preferably about 0.01 to 1% by weight. Will be used.

  Specifically, as such a nonionic surfactant, any conventionally known one can be adopted as long as it is highly safe to living bodies and does not affect the contact lens material. For example, polyglycerin fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene alkyl ether phosphoric acid, polyoxyethylene alkyl amine, polyoxyethylene alkyl amide, polyoxyethylene alkyl phenyl ether, polyoxyethylene alkyl phenyl ether formaldehyde condensate, Polyoxyethylene-polyoxypropylene alkyl ether, polyoxyethylene-polyoxypropylene block copolymer, polyoxyethylene-polyoxypropylene ethylenediamine, polyoxyethylene castor oil Polyoxyethylene hydrogenated castor oil, polyoxyethylene fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene sorbit fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sterol, polyoxyethylene hydrogenated sterol, polyoxyethylene lanolin Alcohol etc. can be mentioned. Among them, in particular, Pluronic, Pluronic R, Tetronic, Tetronic R, which are polyoxyethylene-polyoxypropylene block copolymers that are commercially available as nonionic surfactants (above, Germany: manufactured by BASF) ), Specifically, poloxamer 124, poloxamer 188, poloxamer 237, poloxamer 338, poloxamer 407, tetronic 904, tetronic 908, tetronic 1304, tetronic 1107, polyoxyethylene sorbitan fatty acid ester polysorbate 80, etc. , Will be used advantageously.

  Further, in the cleaning / preserving solution for oxygen permeable hard contact lenses according to the present invention, in addition to the surfactant as described above, polyhydric alcohols may be used as a wetting agent for adjusting compatibility and feeling of use. Can be appropriately contained within a range that does not affect lens compatibility.

  As the polyhydric alcohol, a dihydric alcohol which is alkylene glycol or a derivative thereof, or a bivalent or trivalent alcohol which is a glycerin or a derivative thereof is preferably used. In particular, an alkyl group having 2 to 8 carbon atoms. A dihydric or trivalent alcohol having a main chain, specifically ethylene glycol, propylene glycol, butylene glycol or pentylene glycol, hexylene glycol, or the like is preferably used, and these may be used alone or in combination. Will be used. Among them, glycerin and propylene glycol are advantageous because of excellent compatibility and low cost. Moreover, since it also has a function as an antifreeze agent, the effect of preventing freezing can be obtained when used in a low temperature environment. The concentration of the polyhydric alcohol in the liquid composition is not particularly limited, but is generally about 0.01 to 5% by weight, preferably about 0.1 to 3% by weight, more preferably It will be used at a concentration of about 0.25 to 2.5% by weight. If the polyhydric alcohol concentration is too high, the lens compatibility may be adversely affected.

  In addition, in the oxygen permeable hard contact lens cleaning / preserving solution according to the present invention, a chelating agent, a pH adjusting agent, a buffering agent, a thickening agent, a wetting agent, etc. Any known various additives that have been added to and contained in conventional cleaning / preserving solutions may be appropriately contained. As such additives, any conventionally known additives can be used as long as they are highly safe to living bodies and do not affect the shape or physical properties of the contact lens. In a quantitative range that does not impair the action and effect of, it can be added and contained as appropriate.

  Therein, the chelating agent is contained in order to prevent metal ions such as calcium in tears from depositing on the contact lens. For example, ethylenediaminetetraacetic acid (EDTA), ethylenediaminetetraacetic acid, disodium (EDTA · 2Na), ethylenediaminetetraacetic acid salts such as ethylenediaminetetraacetic acid · trisodium (EDTA · 3Na), nitrilotriacetic acid and its salts, hydroxyethanedisulfonic acid and its salts, citric acid, gluconic acid, tartaric acid , And salts thereof (for example, sodium salt). Further, the concentration of the chelating agent in the cleaning / preserving solution for the oxygen permeable hard contact lens according to the present invention is not particularly limited, but in general, the concentration is about 0.01 to 1.0% by weight. Adopted. In addition, when the concentration of the chelating agent is too high, the above-described effect is not further enhanced, which is not preferable because it is disadvantageous in terms of cost. This is not desirable because the effect may not be sufficiently exhibited.

  Further, in the cleaning / preserving solution for an oxygen permeable hard contact lens according to the present invention, if the pH value becomes too large or conversely too small, the skin is irritated or the lens is adapted. The pH value is usually adjusted to about 4.0 to 9.0, preferably about 6.0 to 8.0, because it may adversely affect the properties. Desirably, an appropriate pH adjusting agent or buffering agent can be appropriately added as necessary.

  Examples of the pH adjusting agent that can be used for adjusting the pH include sodium hydroxide and hydrochloric acid, but are not limited thereto.

  On the other hand, the buffering agent for effectively maintaining the pH of the washing / preserving solution in the above-mentioned range is not particularly limited in the present invention, and is appropriately selected from conventionally known various types. Will be used. Specifically, citric acid, malic acid, lactic acid, ascorbic acid, maleic acid, gluconic acid, phosphoric acid, boric acid, oxycarboxylic acid, amino acids such as glycine and glutamic acid, tris (hydroxymethyl) aminomethane (Tris) Acids and salts thereof (for example, sodium salts), Good-Buffer containing taurine and derivatives thereof, hydroxyalkylamines such as bis (2-hydroxyethyl) iminotris (hydroxymethyl) methane (Bis-tris), etc. It is advantageously used because it is safe for eyes and skin and has little influence on contact lenses, and in particular, citric acid and its salts, phosphoric acid, boric acid, Good-Buffer, hydroxyalkylamine, etc. It can be employed more advantageously. In addition, although the content density | concentration of the buffer in the washing | cleaning / preservation liquid for oxygen permeable hard contact lenses according to this invention is not specifically limited, Generally, it is about 0.01-2 w / w%. If the concentration of such a buffering agent is too high, not only is the buffering capacity higher than necessary, but it is also undesirable in terms of safety, such as irritation to the eyes and skin, etc. When the concentration of such a buffering agent is too low, the target buffering capacity may not be sufficiently exhibited, which is not desirable.

  Examples of the thickener that can be used in the present invention include synthetic organic polymer compounds such as polyvinyl alcohol (PVA), poly-N-vinylpyrrolidone (PVP), polyethylene glycol, polypropylene glycol, polyacrylamide, and the like. Examples thereof include cellulose derivatives such as ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose (HPMC), starch derivatives such as sodium carboxymethyl starch and hydroxyethyl starch, guar gum derivatives, chondroitin sulfate, and hyaluronate. Among them, hydroxypropylmethylcellulose can be used particularly advantageously because it has been used as a component of a liquid composition for contact lenses, and can be expected to remove lipids attached to contact lenses. Such a thickener can advantageously adjust the viscosity of the intended cleaning / preserving liquid, and therefore the lens processed with the cleaning / preserving liquid containing such a thickening agent. Thus, the moisture retention and wettability can be further advantageously enhanced, and a much better wearing feeling can be provided. The concentration of the thickener in the cleaning / preserving solution according to the present invention is not particularly limited, but is generally about 0.01 to 5.0 w / w%, preferably 0.05 to 3. The concentration is about 0 w / w%. If the concentration of the thickener is too high, the viscosity of the finally obtained cleaning / preserving solution becomes too high, which may cause deterioration in handling properties and the like. When the concentration of the agent is too low, there is a possibility that a sufficient thickening effect may not be obtained, which is not desirable.

  In preparing an oxygen permeable hard contact lens cleaning / preserving solution according to the present invention containing each of the components as described above, no special method is required and a normal aqueous solution is prepared. Similarly, each component may be dissolved in any order in an aqueous medium such as purified water or distilled water, and can be easily obtained.

  The cleaning / preserving liquid according to the present invention thus obtained is used as a cleaning liquid or a preserving liquid for the oxygen-permeable hard contact lens after wearing, and further as such a cleaning / preserving liquid. In this case, the sodium salt of the above-mentioned specific anionic surfactant and the amphoteric surfactant are contained in accordance with the present invention. By being contained in combination, excellent lens compatibility, rinsing properties, lipid cleaning power, feeling of use, and antibacterial properties are effectively exhibited. That is, the lens compatibility to the high oxygen permeable hard contact lens can be effectively enhanced, low cytotoxicity is exhibited, the problem of anionic surfactant crystal precipitation is improved, and the high cleaning effect and It has an antibacterial effect, and furthermore, the rinsing property when rinsing with tap water has been improved, so the rinsing time has been shortened and the amount of tap water used can be reduced to less than half. .

  Hereinafter, representative examples of the present invention will be shown to clarify the present invention more specifically, but the present invention is not limited by the description of such examples. It goes without saying. In addition to the following examples, the present invention includes various changes and modifications based on the knowledge of those skilled in the art without departing from the spirit of the present invention, in addition to the specific description described above. It should be understood that improvements can be made.

<Preparation of various test solutions>
First, the various test solutions used in Experimental Examples 1 to 24 are added to the purified water by adding and dissolving predetermined blending components in various ratios shown in Tables 1 to 4 below. Prepared as a wash / preservation solution. In the table, EDTA represents ethylenediaminetetraacetic acid, HPMC represents hydroxypropylmethylcellulose, and PG represents propylene glycol.

<Liquid washing test>
In a 500 mL capacity vial, weigh out 99.000 parts of fat (triglyceride) (weight basis, the same shall apply hereinafter) and 1.000 parts of dye (Sudan I, maximum absorption wavelength: 485.5 nm), about 60 ° C. The mixture was immersed in a hot water bath at a temperature of 5 ° C. and melted by heating. Using a magnetic stirrer, the triglyceride and the pigment were uniformly mixed to prepare colored oils and fats. Subsequently, 3 parts of the colored fats and oils were placed on the bottom of a 100 mL capacity vial and allowed to stand at room temperature to solidify. After the colored fats and oils were solidified, 30 mL of each test solution was added using a whole pipette and allowed to stand in a 25.0 ° C. water bath for 3 hours. After this standing, the supernatant was filtered through a 0.45 μm disposable filter, and the absorbance at 485.5 nm of the obtained filtrate was measured using each test solution as a blank. Then, the obtained absorbance was evaluated based on the following criteria, and the results are shown in Tables 1 to 4 below.
○: Absorbance 0.5 or more Δ: Absorbance 0.25 or more and less than 0.5 ×: Absorbance 0.25 or less

<Antimicrobial test>
An antibacterial test was conducted with reference to “15th revised Japanese Pharmacopoeia Reference Information 28. Preservative Efficacy Test”. First, as test bacteria, Pseudomonas aeruginosa and Staphylococcus aureus, which are particularly problematic for infections in the ophthalmic field, are used, and 10 ⁵ to 10 per mL in various test solutions. ^The seeds were inoculated to ⁶ and cultured at 22 ° C. for 24 hours. And the viable cell count after the culture | cultivation was measured, the logarithmic decrease value of a microbe was calculated from the viable cell count after the culture | cultivation with respect to the inoculum count, and it evaluated based on the following references | standards. The results are also shown in Tables 1 to 4.
○: Log reduction value of 3.0 or more for both of the two types of test bacteria ×: Log reduction value of either or both of the two test bacteria is less than 3.0

<Crystal precipitation test>
80 mL of each test solution is contained in a 100 mL capacity vial, and 10 cycles of repeated freeze treatment at −20 ° C. for 12 hours and 12 hours of thawing at room temperature are repeated. The state of the test solution after the observation was observed. The results are shown in Tables 1 to 4 below, where ◯ indicates that no crystal deposition is observed, and x indicates that crystal deposition is observed.

<Cytotoxicity test>
After immersing in 2 mL of each test solution for 4 hours as one cycle, a commercially available oxygen-permeable hard contact lens: Menicon Z (Dk value: 64, manufactured by Menicon Co., Ltd.) was subjected to 30 cycles, In 25 mL of physiological saline, stirring and washing were performed three times to obtain a test lens for each test solution. Next, this test lens is attached to the appendix “Medical Device Biology for Reference Materials on Basic Concepts of Biological Safety Tests (Office Communication Medical Device Examination No. 36, March 19, 2003)”. The cytotoxicity test was conducted with reference to the direct contact method described in “Test Methods for Evaluation of Physical Safety”. Specifically, first, a fresh medium (5 vol% fetal calf serum-added MEM solution) was injected into a 24-well plate for cell culture, and V79 cells (so that the number of cells per well was 50) ( Chinese hamster lung fibroblasts) were seeded. Subsequently, after storing in a carbon dioxide incubator for 4 hours, the test sample was immersed in a well and cultured in a carbon dioxide incubator for 7 days. After this culturing, the obtained culture solution and test solution were removed, ethanol fixation (5 minutes) and Giemsa staining (30 minutes) were carried out, followed by washing with tap water, followed by air drying and observation. The criteria for evaluation are as follows: ◯: Colonies were formed at the contact portions with the lens, ×: Colonies were not formed at the contact portions with the lenses, and the results are shown in Tables 1 to 1 below. Also shown in FIG.

<Usage test>
A commercially available oxygen-permeable hard contact lens: Menicon Z was used, which was rinsed with tap water and air-dried to obtain a test lens. Then, 50 μL of each test solution is dropped on one of the test lenses and rubbed for 30 seconds. Regarding the slipperiness at the time of rubbed, ○: The lens slide is good and the stickiness is also good. None, x: Evaluation was made based on the criterion that the slipperiness of the lens was poor or / and had stickiness. Also, rinse the test lens after scrubbing with tap water for 10 seconds, compare its rinsability, ○ if the lens and fingers do not have a null feeling, × if the lens or / and fingers have a null feeling, × evaluated.

And based on these two evaluations, the usability about each test solution was determined comprehensively according to the following criteria, and the results are shown in Tables 1 to 4 below.
○: Both slipping and rinsing properties ○
△: Either slipperiness or rinsing property is ○
×: Both slipping and rinsing properties are ×

<Lens compatibility test>
This test was performed by measuring the radius of curvature with reference to “ISO 10338: 1996 (E) Optics and optical instruments-Contact lenses-Determination of curvature”. Specifically, first, for a commercially available oxygen-permeable hard contact lens: Menicon Z (lens power: −3D, −7D) for which the radius of curvature before the cycle treatment was measured, it was immersed in 2 mL of each test solution. This was defined as one cycle, and 30 cycles were carried out, and the radius of curvature of the lens after the 30 cycle treatment was measured. And the difference of the curvature radius before and behind this 30 cycle process was computed, and it evaluated on the following references | standards, and the result was combined with following Table 1-Table 4, and was shown.
○: Change amount is less than 0.05 mm Δ: Change amount is 0.05 mm or more and less than 0.07 mm ×: Change amount is 0.07 mm or more

  As is clear from the results of Tables 1 to 4, in Experimental Examples 1 to 12 using the cleaning / preserving solution according to the present invention, all of the lipid cleaning effect, antibacterial effect, crystal precipitation, cytotoxicity, It was recognized that both the usability and the lens compatibility were excellent.

On the other hand, in Experimental Example 13 using the test solution containing the A component alone and not containing the B component, the lipid cleaning effect and the antibacterial effect, and further the crystal precipitation, are inferior. In Experimental Example 14 using the test solution containing only the B component without the A component, it became clear that the cytotoxicity and usability were inferior. In addition, when the content of the A component is small (Experimental Example 15) or when an anionic surfactant other than the A component is used (Experimental Example 22), the feeling of use is inferior. When the content increases (Experimental Examples 16 and 17) or when the content of the component B increases (Experimental Examples 19 and 20), it is also recognized that the lens compatibility deteriorates. Further, when the content of the B component is reduced (Experimental Examples 18 and 21), the antibacterial effect and crystal precipitation are deteriorated, and amphoteric surfactants other than the B component specified in the present invention are used. In the case (Experimental Examples 23 and 24), sufficient antibacterial effect cannot be exhibited.

Claims (12)

A component composed of at least one selected from sodium salts of sulfonic acid type and sulfate ester type anionic surfactants is contained in the range of 0.2 wt% or more and less than 1 wt%, and lauryl B component composed of at least one selected from amphoteric surfactants consisting of dimethylaminoacetic acid betaine, lauryl dimethylamine oxide and lauryl hydroxysulfobetaine is in the range of 0.1 wt% or more and 0.8 wt% or less in containing and with said component a and said component B at a weight ratio of 2: 1 to 6: oxygen permeability hard contact lens washing Kiyoshiho, characterized by being made to a proportion of 1 Existing liquid. 2. The oxygen-permeable hard contact lens according to claim 1, wherein the component A is composed of at least one selected from α-olefin sulfonate Na, lauryl sulfate Na, lauryl sulfoacetate Na and POE lauryl ether sulfate Na. use wash Kiyoshiho exist solution. The chelating agent, further oxygen permeability hard contact lens washing Kiyoshiho presence liquid according to claim 1 or claim 2 containing. The chelating agent, ethylenediaminetetraacetic acid and salts thereof, nitrilotriacetic acid and its salts, hydroxy ethane diphosphonic acid and oxygen permeability hard contact lens washing Kiyoshiho presence solution according to claim 3 which is selected from a salt thereof. Thickener, further oxygen permeability hard contact lens washing Kiyoshiho presence liquid according to any one of claims 1 to 4 containing. Wherein the thickener is a cellulose derivative, guar gum derivatives, oxygen permeability hard contact lens washing Kiyoshiho presence liquid according to claim 5 selected from PVP and PVA. A wetting agent, further oxygen permeability hard contact lens washing Kiyoshiho presence liquid according to any one of claims 1 to 6 containing. It said wetting agent is an oxygen permeable hard contact lens washing Kiyoshiho presence liquid according to claim 7, which is a polyhydric alcohol. The Dk values cleaning or conserved oxygen permeability hard contact lenses, oxygen-permeable hard contact lens washing Kiyoshiho presence liquid according to any one of claims 1 to 8 is 60 or more. The Dk values cleaning or conserved oxygen permeability hard contact lenses, oxygen-permeable hard contact lens washing Kiyoshiho presence liquid according to any one of claims 1 to 9 120 or more. A component composed of at least one selected from sodium salts of sulfonic acid type and sulfate ester type anionic surfactants is contained in the range of 0.2 wt% or more and less than 1 wt%, and lauryl B component composed of at least one selected from amphoteric surfactants consisting of dimethylaminoacetic acid betaine, lauryl dimethylamine oxide and lauryl hydroxysulfobetaine is in the range of 0.1 wt% or more and 0.8 wt% or less A cleaning solution for oxygen permeable hard contact lenses, wherein the component A and the component B are contained in a weight ratio of 2: 1 to 6: 1. A component composed of at least one selected from sodium salts of sulfonic acid type and sulfate ester type anionic surfactants is contained in the range of 0.2 wt% or more and less than 1 wt%, and lauryl B component composed of at least one selected from amphoteric surfactants consisting of dimethylaminoacetic acid betaine, lauryl dimethylamine oxide and lauryl hydroxysulfobetaine is in the range of 0.1 wt% or more and 0.8 wt% or less And a storage solution for oxygen-permeable hard contact lenses, wherein the component A and the component B are contained in a weight ratio of 2: 1 to 6: 1.