JP5682264B2 - Oral composition and tooth surface adhesion inhibitor for periodontal disease-causing bacteria - Google Patents

Description

  The present invention relates to an oral composition excellent in the effect of suppressing adhesion of periodontal disease-causing bacteria to the tooth surface and a tooth surface adhesion inhibitor of periodontal disease-causing bacteria.

Conventionally, various medicinal ingredients have been incorporated into oral compositions such as dentifrices and mouthwashes as preventive or therapeutic agents for gingivitis and periodontitis.
The causes of gingivitis and periodontitis are caused by various bacteria in dental plaque. As an effective means to prevent and ameliorate these diseases, the number of causative bacteria is low for plaque control, especially periodontopathogenic plaques. It is useful to keep the level. One of the means is an oral composition containing many bactericides such as cationic bactericides such as cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, and nonionic bactericides such as isopropylmethylphenol and triclosan. It is conventionally known that it is effective for prevention and improvement of oral diseases. For example, it is known that triclosan is blended in a dentifrice composition as a plaque inhibitor (Patent Document 1; Japanese Patent Laid-Open No. 60-239410), and a phenolic compound such as thymol is also blended in an oral composition. It is known that dental plaque is suppressed by this (Patent Document 2; JP-T-2001-526202).

However, many of these fungicides are effective against bacteria floating in saliva, etc., but are known not to act effectively against bacteria in dental plaques that form biofilms. Yes. In addition, the bitterness and pungent taste of these fungicides also have the problem that the feeling of use of the composition is impaired.
Under such circumstances, it is desired to develop a composition for oral cavity that can effectively suppress the formation of plaque and has good general characteristics such as feeling of use.

  On the other hand, propylene glycol alginate is mainly used as a binder for dentifrice compositions, and is used for the purpose of improving liquid separation and viscosity reduction of toothpaste (Patent Document 3; JP-A-11-71250). No. 5, Patent Document 4; JP-A-11-71251), used for suppressing adsorption of fat-soluble vitamins in a container containing a semi-solid agent (Patent Document 5; JP-A-2005-343834), essential oil It is used for masking taste derived from it (Patent Document 6; JP-T 2009-520802). For the prevention of oral diseases, water-soluble hydrofluoric acid salt and water-soluble calcium salt, together with substances that promote their colloidalization, have both stable retention of fluoride colloid and caries-preventing action. A composition has been proposed (Patent Document 7; JP-A-4-221307). Moreover, the combined use with the triclosan is made for the purpose of improving the retention of a disinfectant, suppressing plaque formation and preventing gingivitis (Patent Document 8; JP-A-4-139118).

JP 60-239410 A Special table 2001-526202 gazette JP-A-11-71250 JP-A-11-71251 JP 2005-343834 A Special table 2009-520802 JP-A-4-221307 JP-A-4-139118

  The present invention has been made in view of the above circumstances, and is excellent in the effect of suppressing the adhesion of periodontal disease-causing bacteria to the tooth surface, and has good general characteristics such as a feeling of use and the teeth of periodontal disease-causing bacteria. It aims at providing a surface adhesion inhibitor.

  As a result of intensive studies to achieve the above object, the present inventors have found that (A) one or more selected from propylene glycol alginate, (B) polyvinyl pyrrolidone, methyl vinyl ether maleic anhydride copolymer, and pullulan. In combination with the above polymer compound, the mass ratio of component (B) / component (A) is 0.05 to 50, so that the feeling of use excellent in the effect of inhibiting the adhesion of periodontal disease-causing bacteria to the tooth surface is achieved. The inventors have found that a good preparation can be obtained, and have made the present invention.

The present inventors have studied non-bactericidal plaque control means, and in the past, inhibit the adhesion of periodontal disease-causing bacteria, particularly Porphyromonas gingivalis, to the tooth surface with propylene glycol alginate. It was found that it has an unknown effect and is useful for plaque control. Furthermore, propylene glycol alginate has a problem that when it is added to the preparation in an effective amount sufficient to exert its bacterial adhesion inhibitory effect, the feeling of use decreases, such as the taste of the preparation becoming oily. By using a polymer compound selected from polyvinyl pyrrolidone, methyl vinyl ether maleic anhydride copolymer and pullulan in combination with glycol ester, these problems are also eliminated, and adhesion to the tooth surface of periodontal disease-causing bacteria is excellent. At the same time, the company succeeded in developing a preparation with a good feeling of use. Furthermore, the present invention can provide a preparation with good appearance stability.
In addition, it is hard to anticipate the technique which suppresses the tooth surface adhesion of the periodontal disease cause microbe by alginate propylene glycol ester from a prior art.

Therefore, the present invention provides the following oral composition and periodontal disease-causing agent for suppressing tooth surface adhesion.
Claim 1:
(A) 0.01 to 2% by mass of propylene glycol alginate, and (B) 0.005 to 2% by mass of one or more polymer compounds selected from (B) polyvinylpyrrolidone, methyl vinyl ether maleic anhydride copolymer, and pullulan A liquid, paste-like or gel-like composition for oral cavity , characterized in that the mass ratio of component (B) / component (A) is 0.05 to 50 .
Claim 2 :
(A) according to claim 1 An oral composition according to degree of esterification of propylene glycol alginate is equal to or less than 70%.
Claim 3:
The composition for oral cavity according to claim 1 or 2, which is a dentifrice, mouthwash, gel, ointment, or mouth freshener.
Claim 4:
(A) 0.01 to 2% by mass of propylene glycol alginate, and (B) 0.005 to 2% by mass of one or more polymer compounds selected from (B) polyvinylpyrrolidone, methyl vinyl ether maleic anhydride copolymer, and pullulan made, (B) component / (a) weight ratio of component Ru der 0.05 to 50, a liquid, pasty or gel-like periodontal disease-causing bacteria in the tooth surface adhesion inhibitor for the oral composition .

  ADVANTAGE OF THE INVENTION According to this invention, the composition for oral cavity which is excellent in the adhesion inhibitory effect on the tooth surface of a periodontal disease causative microbe, and has favorable general characteristics, such as a feeling of use, and the tooth surface adhesion inhibitor of a periodontal disease causative microbe are provided. it can.

  The composition for oral cavity of the present invention contains (A) propylene glycol alginate, and (B) one or more polymer compounds selected from polyvinylpyrrolidone, methyl vinyl ether maleic anhydride copolymer, and pullulan.

The propylene glycol alginate as the component (A) is blended as an active ingredient for suppressing periodontal disease causative bacteria adhesion.
The propylene glycol alginate is an ester obtained by introducing a propylene glycol group into a carboxyl group in order to increase the acid resistance and salt resistance of natural polysaccharide alginic acid, which is unique to brown algae represented by kombu and wakame. For example, a product commercialized under a trade name such as Duck Lloyd from Food Chemifa Co., Kimiroid from Kimika Co., Ltd. or kelp acid can be used.

  Propylene glycol ester of alginic acid is a quantitative ratio of β-D-mannuronic acid (M) and α-L-guluronic acid (G) constituting alginic acid (M / G ratio, molar ratio, the same shall apply hereinafter), sequence order, and number. (Molecular weight) and the molecular structure differing in the degree of esterification of the carboxyl group and the like, and the viscosity of the aqueous solution due to the difference in the molecular structure can take various values. The propylene glycol alginate used in the present invention is not limited to these molecular structures and viscosities, but the quantitative ratio of β-D-mannuronic acid (M) and α-L-guluronic acid (G) (M / G ratio) is preferably greater than 1.0, particularly preferably greater than 1.0 and 2 or less.

The degree of esterification of the carboxyl group of propylene glycol alginate is preferably 40% or more, particularly 70% or more, and particularly preferably 70 to 95%. The higher the degree of esterification, the more effective the suppression of periodontal disease-causing bacteria on the tooth surface. The higher the degree of esterification, the higher the effect of inhibiting periodontal disease-causing bacteria on the tooth surface. Is optimal. There is nothing in the market that exceeds 95%.
In addition, as a thing with 70% or more of esterification, the brand name made by Kimika Co., Ltd. Kimiloid LLV, Kimiloid BF, Kimiloid HV, kelp acid 503, kelp acid 501, brand name made by Food Chemifa Co., Ltd. PF, duckroid LF, etc. are mentioned.

Further, the viscosity at 20 ° C. (hereinafter, the same shall apply) of a 1% (mass%, the same shall apply hereinafter) aqueous solution by a measuring method using a B-type viscometer described later is 10 to 1,300 mPa · s, particularly 10 to 200 mPa · s. The range of s is preferable. Those having a viscosity of less than 10 mPa · s are not commercially available, and if it exceeds 1,300 mPa · s, there is a possibility that a sufficient periodontal disease-causing inhibitory effect cannot be obtained.
The propylene glycol alginate can be used alone or in combination of two or more depending on the type of product.

The viscosity is a value measured by a BL type viscometer, and specifically, a measured value by the following method.
Viscosity measurement method (Duck Lloyd, Food Chemifa Corporation)
4 g of propylene glycol alginate is collected and placed in a 600 mL beaker, and 396 g of purified water is added little by little while stirring with a stir bar. First, dissolve well with a small amount of water. Thereafter, the mixture is allowed to swell for 1 hour, and after 1 hour, it is stirred for 1 minute at 12,000 rpm with a high-speed stirrer (homomixer). This solution is put into a 300 mL tall beaker and allowed to stand in a 20 ° C. water bath. When the foam rises and the beaker solution is clear, remove the foam with a spoon. A thermometer is put in a beaker to confirm that the test solution has reached 20 ° C., and the viscosity is measured.
Viscometer: Tokyo Keiki BL type viscometer rotor: No. 1
Rotation speed: 60rpm
Measurement time: 1 minute

Viscosity measurement method (Kimiloid, Kimlicum, Kimika Co., Ltd.)
Take 297 g of purified water in a 300 mL tall beaker and add 3.0 g of alginate propylene glycol ester with stirring with a stirrer or three-one motor to completely dissolve. Next, after standing for 1 hour in a 20 ° C. constant temperature water bath (confirm that the aqueous solution of propylene glycol alginate reached 20 ° C.), a BL type viscometer (manufactured by Tokyo Keiki Co., Ltd.) was used for exactly 1 minute later. Measure the viscosity.
When the viscosity is more than 10 mPa · s and not more than 80 mPa · s: Rotor No. 1. Rotation speed 60rpm
When the viscosity is more than 80 mPa · s and not more than 160 mPa · s: Rotor No. 1, rotation speed 30rpm
When the viscosity is more than 160 mPa · s and not more than 400 mPa · s: Rotor No. 2, rotation speed 60rpm
When the viscosity exceeds 400 mPa · s and is 800 mPa · s or less: Rotor No. 2, rotation speed 30rpm
When the viscosity exceeds 800 mPa · s and is 1,600 mPa · s or less: Rotor No. 3, rotation speed 60rpm

As such propylene glycol alginate, for example, the following commercially available products can be used.
Propylene glycol alginate brand name Kelp acid 503:
1% aqueous solution viscosity 18 mPa · s (rotor No. 1, 60 rpm), M / G ratio = 1.3, degree of esterification = 80% / trade name, manufactured by Kimika Co., Ltd. Kimiloid BF:
1% aqueous solution viscosity 20 mPa · s (rotor No. 1, 60 rpm), M / G ratio = 1.3, degree of esterification = 80% / trade name, manufactured by Kimika Co., Ltd. Kimiloid LLV:
1% aqueous solution viscosity 24 mPa · s (rotor No. 1, 60 rpm), M / G ratio = 1.3, degree of esterification = 80% / trade name, manufactured by Kimika Co., Ltd. Kimiloid NLS-K:
1% aqueous solution viscosity 55 mPa · s (rotor No. 1, 60 rpm), M / G ratio = 1.3, degree of esterification = 80% / trade name, manufactured by Kimika Co., Ltd. Kimiloid LV:
1% aqueous solution viscosity 90 mPa · s (rotor No. 1, 30 rpm), M / G ratio = 1.3, degree of esterification = 80% / trade name, manufactured by Kimika Co., Ltd. Kimiloid MV:
1% aqueous solution viscosity 148 mPa · s (rotor No. 1, 30 rpm), M / G ratio = 1.3, degree of esterification = 80% / trade name, manufactured by Kimika Co., Ltd. Kelp acid 542:
1% aqueous solution viscosity 1,280 mPa · s (rotor No. 3, 60 rpm), M / G ratio = 1.3, degree of esterification = 40% / trade name, manufactured by Kimika Co., Ltd. Duck Lloyd LF:
1% aqueous solution viscosity 21 mPa · s (rotor No. 1, 60 rpm), M / G ratio = 0.8, degree of esterification = 75% / trade name, manufactured by Food Chemifa Corporation Duck Lloyd PF:
1% aqueous solution viscosity 51 mPa · s (rotor No. 1, 60 rpm), M / G ratio = 0.8, degree of esterification = 75% / manufactured by Food Chemifa Corporation

  The blending amount of propylene glycol alginate is 0.01 to 2%, particularly 0.05 to 1.0%, based on the total amount of the composition. When the blending amount is less than 0.01%, a sufficient periodontal disease-causing bacterial adhesion inhibitory effect cannot be obtained, and when it exceeds 2%, a periodontal disease-causing bacterial adhesion inhibitory effect is obtained, but the feeling of use (taste / odor) The deterioration is not improved, and the appearance stability after storage may be deteriorated.

  (B) The high molecular compound of a component is 1 or more types chosen from polyvinylpyrrolidone, a methyl vinyl ether maleic anhydride copolymer, and a pullulan. By blending such a polymer compound in combination with propylene glycol alginate, it has excellent periodontal disease causative adhesion control effect derived from propylene glycol alginate and has a feeling of use and appearance stability of the preparation. Decrease can be improved.

As polyvinylpyrrolidone, those having a weight average molecular weight of 10,000 to 1,500,000, particularly 30,000 to 1,300,000 are preferable. When the weight average molecular weight is less than 10,000, the foam persistence effect may not be sufficiently exhibited. When the weight average molecular weight exceeds 1,500,000, the dispersibility in the oral cavity is deteriorated or the spinnability is generated. May be inferior. Polyvinylpyrrolidone may be used alone or in combination of two or more.
The weight average molecular weight is obtained by converting the K value defined in the United States Pharmacopeia (USP) into a weight average molecular weight measured by a light scattering method (hereinafter the same).

  Commercially available products can be used as the polyvinyl pyrrolidone, for example, trade names such as Rubiscol K30 (weight average molecular weight of about 40,000) and Rubiscol K90 (weight average molecular weight of about 1,200,000) manufactured by BASF Japan Ltd. Is mentioned.

The methyl vinyl ether maleic anhydride copolymer is obtained by copolymerization reaction of methyl vinyl ether and maleic anhydride, and the mixing ratio of methyl vinyl ether and maleic anhydride is not particularly limited.
As the molecular weight of the copolymer, those having a weight average molecular weight of 5,000 to 5,000,000, particularly 10,000 to 3,000,000 can be suitably used. When the weight average molecular weight is less than 5,000, the effect of improving the feeling of use (taste / odor) may not be obtained, and when it exceeds 5,000,000, the dispersibility in the oral cavity is deteriorated or the spinnability is increased. May be inferior to the feeling of use. In addition, the measuring method of a weight average molecular weight is the same as that of the said polyvinylpyrrolidone.

  Such a methyl vinyl ether maleic anhydride copolymer is commercially available from ISP under the trade name GANTREZ, for example, GANTREZ AN-119, AN-139, AN-149, AN-169, S-97. , S-95 and the like.

Pullulan is a polysaccharide having a structure in which maltotriose in which three glucose molecules are α1-4 linked by α1-6 bonds, and is the same as that used as a lubricant, adhesive, coating agent, etc. Can be used. A commercial product sold as a food additive pullulan from Hayashibara Corporation can also be used. As specifications of the product, those having a pH of 5.0 to 7.0 (10% aqueous solution) and a kinematic viscosity of 100 to 180 mm ² / s (10%, 30 ° C.) can be preferably used.

  As the polymer compound (B), one kind selected from polyvinyl pyrrolidone, methyl vinyl ether maleic anhydride copolymer and pullulan may be used alone, or two or more kinds may be used in combination. Among these, pullulan is more preferable in this respect because it can most improve the taste of the preparation.

  (B) The compounding quantity of a high molecular compound is 0.005-2% with respect to the whole quantity of a composition, Especially 0.01-1% is suitable. If the blending amount is less than 0.005%, the effect of improving the appearance stability after storage and the effect of improving the feeling of use (taste / odor) may not be obtained. There may be a problem with the appearance stability.

  The blending ratio of the polymer compound (B) and the propylene glycol alginate (A) component is such that (B) / (A) is in a mass ratio of 0.05 to 50, particularly 0.1 to 10. It is preferable from the viewpoint of adhesion prevention effect of periodontal disease-causing bacteria and ensuring appearance stability after storage. When (B) / (A) is less than 0.05, the feeling of use (taste / odor) of the composition cannot be improved. Furthermore, there is a problem in appearance stability after storage, which is not preferable for use. If it exceeds 50, a satisfactory periodontal disease-causing adhesion inhibitory effect cannot be obtained.

  The composition for oral cavity of the present invention is in the form of liquid, basto, gel, etc., and is a toothpaste such as toothpaste, toothpaste, liquid dentifrice, mouthwash, gel, ointment, mouth freshener, gargle Can be prepared in various dosage forms such as tablets for oral use, pasta for oral cavity, gum, etc., and in accordance with the dosage form, known ingredients other than the above components (A) and (B) are blended within a range that does not impair the effects of the present invention. It can be prepared by the method. In the case of a toothpaste, for example, various abrasives, wetting agents, binders, surfactants, sweeteners, colorants, preservatives, fragrances, pH adjusters, and other active ingredients can be blended. In liquid dentifrice, a solvent, a wetting agent, a thickener, a pH adjuster, a preservative, a sweetener, a fragrance, a surfactant, an active ingredient, a colorant, and the like can be blended.

  As abrasives, precipitated silica, silica gel, aluminosilicate, zeolite, zirconosilicate, dicalcium phosphate dihydrate and anhydride, calcium pyrophosphate, calcium carbonate, aluminum hydroxide, alumina, magnesium carbonate, tertiary phosphorus Examples include magnesium oxide, insoluble sodium metaphosphate, insoluble potassium metaphosphate, titanium oxide, hydroxyapatite, and synthetic resin-based abrasives (blending amount; usually 5 to 50% when blended, 0 to 30 for liquid dentifrice %.).

  Examples of the wetting agent include glycerin, sorbitol, propylene glycol, polyethylene glycol, 1,3-butylene glycol, xylite, maltite, lactit, trehalose, tornale and the like (mixing amount: usually 0 to 50%, particularly 5 to 45). %).

  As binder, carrageenan, sodium carboxymethylcellulose, sodium alginate, polyacrylic acid, sodium polyacrylate, carboxyvinyl polymer, polyvinyl alcohol, xanthan gum, tara gum, guar gum, locust bean gum, gellan gum, gelatin, curdlan, gum arabic , Agar, pectin and the like (blending amount; usually 0.1 to 5%).

As the surfactant, an anionic surfactant, a nonionic surfactant, a cationic surfactant, or an amphoteric surfactant may be used alone or in combination of two or more.
Examples of the anionic surfactant include sodium lauryl sulfate, sodium lauroyl sarcosine, lauroyl methyl taurine, acyl amino acid salt, sodium dodecylbenzenesulfonate, α-sulfo fatty acid alkyl ester / sodium, alkyl phosphate ester salt and the like. Nonionic surfactants include polyglycerin fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester, polyoxyethylene polyoxypropylene block Examples include copolymer type activators, polyoxyethylene fatty acid esters, fatty acid monoglycerides, and the like. Examples of amphoteric surfactants include betaine acetate-type amphoteric surfactants such as alkyldimethylaminoacetic acid betaines and fatty acid amidopropyldimethylaminoacetic acid betaines, and imidazoline types such as N-fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine salts. Examples include amphoteric surfactants and amino acid type surfactants such as N-fatty acid acyl-L-alginate salts. Examples of the cationic surfactant include alkylammonium and alkylbenzylammonium salts (blending amount: usually 0.1 to 5%).

Examples of the sweetener include saccharin, saccharin sodium, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl hydrochalcone, perilartine, xylitol, maltitol, sucralose, reduced palatinose, erythritol, aspartame and the like.
Examples of the colorant include blue No. 1, yellow No. 4, titanium dioxide and the like.
Examples of the preservative include sodium benzoate, p-hydroxybenzoate ester, alkyldiaminoethylglycine hydrochloride, potassium sorbate and the like.

  Natural flavors such as peppermint oil, spearmint oil, eucalyptus oil, wintergreen oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, marjoram oil, lemon oil, nutmeg oil, lavender oil, paracres oil, etc. Essential oil, and l-menthol, l-carvone, cinnamic aldehyde, orange oil, anethole, 1,8-cineole, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, camphor, borneol, pinene, Perfume ingredients contained in the above natural essential oils such as spiranthol, ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methyl anthranilate, ethyl methyl phenyl glycidate Benzaldehyde, vanillin, ethyl vanillin, furaneol, maltol, ethyl maltol, gamma / delta decalactone, gamma / deltown decalactone, N-ethyl-p-menthane-3-carboxamide, menthyl lactate, ethylene glycol 1-menthyl carbonate Perfume ingredients such as apple, banana, strawberry, blueberry, melon, peach, pineapple, grape, muscat, wine, cherry, squash, coffee, brandy, yogurt 1 type or 2 types or more of compounding flavors, such as these, are mentioned (blending amount; Usually, 0.00001 to 3%).

  Examples of pH adjusting agents include phthalic acid, phosphoric acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid, carbonic acid and their potassium salts, sodium salts or ammonium salts, ribonucleic acid and salts thereof, sodium hydroxide, etc. 1 type (s) or 2 or more types can be used.

  Other active ingredients include cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, chlorhexidine hydrochloride, alkyldiaminoethylglycine hydrochloride, triclosan, isopropylmethylphenol, hinokitiol, and other fungicides, tranexamic acid, epsilon-aminocaproic acid, azulene, aratoin , Allantoin chlorohydroxyaluminum, allantoindihydroxyaluminum, glycyrrhetin salts, glycyrrhetinic acid, dihydrocholesterol, hydrocholesterol and other anti-inflammatory agents, dextranase, lysozyme chloride, amylase, protease, mutanase, lytic enzyme, lytechenzyme, etc. Sodium fluoride, sodium monofluorophosphate, fluoride such as stannous fluoride, ascorbate Vitamins such as tocopherol acetate, plant extracts such as thyme, hornon, clove, hamamelis, chlorophyll, copper chlorophyllin sodium, copper gluconate, caropeptide, sodium polyphosphate, water-soluble inorganic phosphate compound, polyethylene glycol, potassium nitrate, aluminum lactate Etc. can be added.

  According to the present invention, it comprises (A) propylene glycol alginate, and (B) one or more polymer compounds selected from (B) polyvinylpyrrolidone, methyl vinyl ether maleic anhydride copolymer, and pullulan. (A) The tooth surface adhesion inhibitor of the periodontal disease causative microbe whose mass ratio of a component is 0.05-50 can be provided. In addition, (A) and (B) component, also another compounding component, its compounding quantity, a ratio, etc. are all the same as the said description.

  EXAMPLES Hereinafter, although an experimental example, an Example, a comparative example, a formulation example is shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples,% indicates mass%.

[Experimental example]
Test compositions having the following compositions (Examples and Comparative Examples) were prepared by the following methods and evaluated by the following methods. The results are shown in Tables 1-4.
Composition of test compositions (Examples and Comparative Examples):
The mouthwash composition of the test composition is as follows.
Test composition (mouth wash) composition ethanol (manufactured by Wako Pure Chemical Industries, Ltd.) 5.0%
Glycerin (made by Lion) 10.0%
Polyoxyethylene (60) hydrogenated castor oil (manufactured by Nippon Surfactant)
0.3%
Saccharin sodium 0.1%
Sodium lauryl sulfate (Wako Pure Chemical Industries, Ltd.) 0.1%
(A) Component Types and blending amounts described in Tables 1 to 4 (B) Component Types and blending amounts described in Tables 1 to 4
Purified water remaining
Total 100.0%

The raw materials used are as follows.
Propylene glycol alginate (PG) ester Kimiloid BF: Degree of esterification 80%, M / G ratio 1.3
Viscosity 20 mPa · s, manufactured by Kimika Co., Ltd. Kelp acid 542: Degree of esterification 40%, M / G ratio 1.3
Viscosity: 1,280 mPa · s, manufactured by Kimika Co., Ltd. Duck Lloyd PF: Degree of esterification 75%, M / G ratio 0.8
Viscosity 51 mPa · s, Polyvinylpyrrolidone Rubiscol K30 manufactured by Food Chemifa Co., Ltd .: Methyl vinyl ether maleic anhydride copolymer manufactured by BASF Japan Co., Ltd. GANTREZ S-97: Pullulan manufactured by ISP Co., Ltd. : Xanthan gum manufactured by Kimika Co., Ltd. Xanthan gum: manufactured by Dainippon Sumitomo Pharma Co., Ltd. The viscosity of propylene glycol alginate is determined by the method described above (BL type viscometer, 20 ° C., 1% aqueous solution, measurement time 1 minute, rotor and The rotational speed is the value measured in the manner described above.

(1) Test composition used to evaluate periodontal disease causative bacteria adhesion and feel of use (taste, smell) of composition The raw material of the test composition of the above composition was dissolved in a 100 mL beaker, and 1N hydrochloric acid or 1N water After neutralization with a sodium oxide solution as necessary, purified water was added so that the total amount became 100 g, to obtain a test composition having the above composition. In addition, as a comparison (control), the thing with the same composition as the said test composition was used except not mix | blending (A) and (B) component.

(2) Test composition used for appearance stability evaluation after storage Dissolve the raw material of the test composition of the above composition in a 1,000 mL beaker and neutralize with 1N hydrochloric acid or 1N sodium hydroxide solution as necessary. After the purification, purified water was added so that the total amount became 1,000 g, to obtain a test composition having the above composition, and 80 mL of a 90 mL PET container was filled.

(3) Evaluation method of adhesion suppression effect of periodontal disease-causing bacteria Periodontal disease-causing bacteria use Porphyromonas gingivalis ATCC33277 purchased from American Type Culture Collection (ATCC) and contain hemin and menadione Cultivate to a steady state under anaerobic conditions (80 vol% nitrogen, 10 vol% carbon dioxide, 10 vol% hydrogen) at 37 ° C. with Todd Hewit broth culture solution (THBHM ^{* 1} ) so that the absorbance at 550 nm becomes 1.0. A liquid suspended in PBS (manufactured by Wako Pure Chemical Industries, Ltd.) was used for the test.
The adherent carrier was immersed in human unstimulated saliva filtered with a 0.45 μm filter for 1 hour (37 ° C.) using a hydroxyapatite (HA) plate (manufactured by Asahi Optical Co., Ltd.) having a diameter of 7 mm and a thickness of 3.5 mm. The HA surface was coated with saliva components and subjected to the test.
The saliva-coated HA plate was washed once with PBS (manufactured by Wako Pure Chemical Industries, Ltd.) and then immersed in 2 mL of the test solutions shown in Tables 1 to 4 for 5 minutes. After the treatment, the plate was washed once with PBS, and then the HA plate was immersed in the aforementioned Porphyromonas gingivalis solution for 30 minutes (37 ° C.). Thereafter, the HA plate was washed 3 times with 1 mL of PBS, and then the adhered bacteria were dispersed by ultrasonication (200 μA, 10 seconds) in 4 mL of PBS, and 10-fold serial dilution was performed. 50 μL of this was smeared on a blood agar plate containing 10% sheep defibrillated blood and cultured under anaerobic conditions for about 2 weeks. Obtain the number of Porphyromonas gingivalis adhering to the HA plate from the number of colonies grown, calculate the number of adhering bacteria as cfu (colony forming unit) / HA plate, and suppress the adhesion of the test composition to the number of adherent bacteria in the control Was determined by the following formula, and the effect of inhibiting periodontal disease causative bacteria adhesion was determined according to the following criteria.
Adhesion inhibition rate (%) = ((number of adherent bacteria of control−number of adherent bacteria of test composition) / number of adherent bacteria of control)) × 100

Criteria for Adhesion Inhibitory Effect of Periodontal Disease Causative Bacteria ◎: Adhesion inhibition rate is 80% or more and 100% or less ○: Adhesion inhibition rate is 60% or more and less than 80% Δ: Adhesion inhibition rate is 40% or more and less than 60% ×: Adhesion suppression rate is 0% or more and less than 40%

^{* 1} Composition of THBHM: Expressed by mass in 1 liter.
Todd Hewitt Broth (Becton and Dickinson): 30g / L
Hemin (Sigma Aldrich): 5mg / L
Menadion (Wako Pure Chemical Industries, Ltd.): 1mg / L
Distilled water: Residue (Measured up to a total volume of 1 L and autoclaved at 121 ° C. for 20 minutes.)

^{* 2} Composition of blood agar plate medium: Expressed by mass in 1 liter.
Todd Hewitt Broth (Becton and Dickinson): 30g / L
Agar (Becton and Dickinson): 15g / L
Hemin (Sigma Aldrich): 5mg / L
Menadion (Wako Pure Chemical Industries, Ltd.): 1mg / L
Distilled water: Residue (Measured up to a total volume of 1 L and autoclaved at 121 ° C. for 20 minutes.)
100ml of degummed blood from sheep
(After autoclaving, add it after cooling to 50 ° C.)

(4) Evaluation method of feeling of use (taste / smell) The feeling of use (taste / odor) of the test composition was evaluated by sensory evaluation by a human use test. That is, a test tube containing 5 g of the test composition was stirred for 10 seconds with a vortex mixer for 10 subjects, and then the taste and smell of the test composition were evaluated according to the following scores. The results were obtained from the average of 10 people according to the following evaluation criteria.

Score:
4 points: Taste and smell are better than the control.
3 points: Taste and odor are comparable to controls and are fairly good 2 points: Slightly different taste and odor are felt compared to controls and slightly inferior.
1 point: A distinctly different taste and smell are felt compared to the control, which is inferior.
Evaluation criteria:
◎: The score is 3.5 or more and 4 or less ○: The score is 3 or more and less than 3.5 △: The score is more than 2 and less than 3 ×: The score is 2 or less

(5) Appearance stability evaluation after storage of composition The test composition filled in a 90 mL PET container was visually judged according to the following criteria for orientation and stagnation after storage at 50 ° C for 1 month. Of the evaluations of “ori” and “nigori”, when the evaluations are different, the worse score was used as the score value of appearance stability after storage.

Orientation evaluation criteria:
(Double-circle): The orientation which sinks when a PET container is moved slowly is not recognized at all.
○: Almost no sediment is observed when the PET container is gently moved.
(Triangle | delta): The orientation which sinks when a PET container is gently moved over is clearly recognized.
X: Orientation is recognized without gently changing the PET container.

Nigori evaluation criteria:
A: There is no negligence. Even if compared with a PET container filled with purified water, no scratches are observed.
○: Slight scratching is observed compared to a PET container filled with purified water, but there is no problem because the level cannot be determined without comparison.
Δ: Slightly observed as compared with a PET container filled with purified water, but slightly observed without comparison.
X: Even if compared with a PET container filled with purified water, the scratches are clearly observed, and it is so cloudy that it is difficult to see through the other side of the PET container.

  Hereinafter, a prescription example is shown. In addition, the thing of the composition shown in Table 5 was used as fragrance | flavor AG in a prescription example.

* Fruit mix flavor FM3000 (mixed fragrance)
Strawberry flavor 40%
Apple flavor 15
Melon Flavor 17
Banana Flavor 10
Peach Flavor 5
Orange oil 2.5
Raspberry flavor 2.0
Pineapple flavor 1.5
Grape flavor 1.0
Tropical fruit flavor 1.5
Milk flavor 1.0
Grapefruit oil 0.5
Lemon oil 0.5
Rose oil 0.2
Solvent residue
Total 100.0%

[Prescription Example 1] Toothpaste dicalcium phosphate 45.0%
Silica anhydride 2.0
Sorbit (70% aqueous solution) 25.0
Propylene glycol 2.0
Sodium carboxymethylcellulose 1.0
Sodium lauryl sulfate 1.5
Polyoxyethylene (20) hydrogenated castor oil 0.8
Saccharin sodium 1.0
Sodium benzoate 0.1
Fragrance A 1.0
Alginic acid propylene glycol ester 0.1
(Product name Kimiroid BF)
Pullulan (Food additive pullulan manufactured by Hayashibara Corporation) 0.5
Purified water remaining
Total 100.0%

[Prescription Example 2] Toothpaste calcium carbonate 40.0%
Propylene glycol 4.0
Glycerin 20.0
Sodium carboxymethylcellulose 1.5
Titanium oxide 0.5
Sodium lauryl sulfate 0.8
Saccharin sodium 0.1
Ethyl paraoxybenzoate 0.1
Fragrance B 1.0
Alginic acid propylene glycol ester 0.2
(Product name: Duck Lloyd PF)
Methyl vinyl ether maleic anhydride copolymer 0.5
(Brand name GANTREZ S-97)
Purified water remaining
Total 100.0%

[Prescription Example 3] Liquid dentifrice glycerin 25.0%
Sorbit liquid (70% aqueous solution) 25.0
Propylene glycol 5.0
Silicic anhydride 0.3
Sodium lauryl sulfate 1.0
Polyoxyethylene (60) hydrogenated castor oil 1.0
Saccharin sodium 0.2
Sodium benzoate 0.3
Fragrance D 1.0
Alginic acid propylene glycol ester 0.1
(Product name Kelp acid 542)
Polyvinylpyrrolidone (trade name: Rubiscol K90) 0.2
Purified water remaining
Total 100.0%

[Prescription Example 4] Mouthwash ethanol 10.0%
Glycerin 2.0
Polyoxyethylene (60) hydrogenated castor oil 0.2
Saccharin sodium 0.1
Fragrance C 1.0
Alginic acid propylene glycol ester 0.1
(Product name Kimiroid BF)
Polyvinylpyrrolidone (trade name Rubiscol K90) 0.1
Purified water remaining
Total 100.0%

[ Reference Example 1 ] Oral lozenge gum for oral use 6.0%
Glucose 36.0
Palatinose 36.0
Fragrance F 1.3
Alginic acid propylene glycol ester 0.2
(Product name Kimiroid BF)
Pullulan (food additive pullulan manufactured by Hayashibara Corporation) 1.0
Purified water remaining
Total 100.0%

[ Reference Example 2 ] Chewing gum gum base 20.0%
Sugar 15.0
Isomaltose 20.0
Palatinose 10.0
Xylitol 10.0
Corn syrup 12.0
Fragrance E 0.6
Alginic acid propylene glycol ester 0.1
(Product name Kelp acid 542)
Pullulan (Food additive pullulan manufactured by Hayashibara Corporation) 0.5
Minamata remaining
Total 100.0%

[ Reference Example 3 ] Candy sugar 50.0%
Minamata 33.0
Organic acid 2.0
Fragrance G 0.2
Alginic acid propylene glycol ester 0.1
(Product name: Duck Lloyd PF)
Polyvinylpyrrolidone (trade name: Rubiscol K90) 0.2
Purified water remaining
Total 100.0%

Claims (4)

(A) 0.01 to 2% by mass of propylene glycol alginate, and (B) 0.005 to 2% by mass of one or more polymer compounds selected from (B) polyvinylpyrrolidone, methyl vinyl ether maleic anhydride copolymer, and pullulan A liquid, paste-like or gel-like composition for oral cavity , characterized in that the mass ratio of component (B) / component (A) is 0.05 to 50. (A) according to claim 1 An oral composition according to degree of esterification of propylene glycol alginate is equal to or less than 70%. The composition for oral cavity according to claim 1 or 2, which is a dentifrice, mouthwash, gel, ointment, or mouth freshener. (A) 0.01 to 2% by mass of propylene glycol alginate, and (B) 0.005 to 2% by mass of one or more polymer compounds selected from (B) polyvinylpyrrolidone, methyl vinyl ether maleic anhydride copolymer, and pullulan made, (B) component / (a) weight ratio of component Ru der 0.05 to 50, a liquid, pasty or gel-like periodontal disease-causing bacteria in the tooth surface adhesion inhibitor for the oral composition .