JP5689288B2 - Topical skin preparation - Google Patents

Description

  The present invention relates to an external preparation for skin having an excellent occlusion effect and stability over time while having a good feeling of use and an excellent feeling of use.

  In general, skin care cosmetics such as milky lotion, cosmetic liquid, and cream are widely used as a skin external preparation that moisturizes the skin and imparts flexibility. These external preparations for skin mainly contain polyhydric alcohols, water-soluble water-soluble polymers and oils, and the water-holding power of polyhydric alcohols and water-soluble water-soluble polymers themselves increases the moisture on the skin. Moisturizing effect is intended to be obtained by keeping it on the skin without being released into the outside air by keeping it for a certain period of time or by a thin film that oil or the like forms on the skin, without releasing the water that evaporates from the skin.

  In order to enhance the effect of polyhydric alcohol and the like, there is a problem that the effect is low unless a large amount of polyhydric alcohol is added. However, when the content of the polyhydric alcohol is increased, it tends to be a destabilizing factor of the emulsification system and it tends to be difficult to ensure stability. As an example of using a water-soluble water-soluble polymer, a polymer or copolymer having 2-methacryloyloxyethyl phosphorylcholine as a constituent monomer, a water-soluble polymer such as a water-containing polymer, or hydroxyalkyl cellulose is used in cosmetics. Thus, cosmetics having a high moisture blocking effect have been proposed (see Patent Documents 1 and 2). However, in order to obtain a sufficient moisturizing effect, increasing the blending amount still increases stickiness and gelation, or polymer agglomerates that are peeled off when stretched on the skin are generated as debris. There was a problem. Furthermore, even a film having a water-holding ability due to a water-soluble polymer is not satisfactory as the effect of suppressing moisture transpiration and is not satisfactory.

  On the other hand, when oil is blended, it is known that the non-polar oil such as petrolatum and liquid paraffin has a large oil blockage, and its force decreases as the polarity increases such as ester oil. For this reason, what was mixed with petrolatum is marketed as a skin external preparation with a high obstruction | occlusion effect.

  However, non-polar oils such as petroleum jelly and liquid paraffin are generally less compatible with sebum, so they slip on the skin even after application, have a slimy feel, and the oil moves to touched clothes and paper etc. There was a problem. In addition, in the case of cosmetics such as foundations in which powders are blended, there is a problem that when the applied skin touches the clothes, the powders easily transfer to the clothes.

Japanese Patent Laid-Open No. 2006-22047 JP-T-2006-509718

  Accordingly, an object of the present invention is to provide an external preparation for skin which has no stickiness, has a refreshing feel, is well-familiar with the skin, and realizes excellent occlusion.

  As a result of investigations to solve the above-mentioned problems, the present inventor has found that the alkyl group or alkenyl group has 20 to 24 carbon atoms and the average added mole number of ethylene oxide is 1.5 to 4 polyoxyethylene alkyl or alkenyl. By using a combination of ether and water-soluble polymer, moisture evaporation is suppressed by the interaction between the hydrophobic group (alkyl group or alkenyl group) and the hydrophilic group (ethylene oxide group) of polyoxyethylene alkyl or alkenyl ether. It has been found that excellent occlusive properties can be obtained. Furthermore, when skin active ingredients, such as a plant extract and (gamma) -amino-beta-hydroxybutyric acid, were used together, it discovered that the effect which those ingredients have increased synergistically.

That is, this invention is a skin external preparation containing the following component (A)-(C).
(A) a polyoxyethylene alkyl or alkenyl ether in which the alkyl group or alkenyl group has 20 to 24 carbon atoms and the average added mole number of ethylene oxide is 1.5 to 4 (B) a water-soluble polymer, and (C ) Skin active ingredients

The external preparation for skin of the present invention has a high moisture transpiration suppressing effect and is excellent in the blocking effect of the coating film after use. In order to keep moisture on the skin stably for a long time, the permeability of skin active ingredients such as plant extracts and γ-amino-β-hydroxybutyric acid to the skin is increased, and the moisturizing effect and anti-inflammatory properties of these skin active ingredients Effects such as effects increase synergistically.
Moreover, since a high moisture transpiration suppressing effect and a blocking effect are manifested by the addition of a small amount of polyoxyethylene alkyl or alkenyl ether, there is no limitation on the dosage form and there is almost no effect on the feeling of use.

It is a graph which shows the change of the stratum corneum moisture content in Test 4. It is a graph which shows the change of the transdermal moisture transpiration amount in Test 4.

  In the polyoxyethylene alkyl or alkenyl ether (A) used in the present invention, the alkyl group or alkenyl group has 20 to 24 carbon atoms, and the average added mole number of ethylene oxide is 1.5 to 4.

  The alkyl group or alkenyl group of the polyoxyethylene alkyl ether may be linear or branched, and the structure thereof is not limited, but is preferably a linear or branched alkyl group, more preferably a linear alkyl group. is there. The alkyl group or alkenyl group has 20 to 24 carbon atoms, preferably 21 to 23 carbon atoms, and most preferably a behenyl group having 22 carbon atoms. When the number of carbon atoms of the alkyl group or alkenyl group is less than 20, it is not preferable because the moisture transpiration suppressing effect and the blocking effect are low. In addition, when the number of carbon atoms of the alkyl group or alkenyl group exceeds 24, it is difficult to dissolve in the aqueous phase, which is not preferable in the preparation.

  The average added mole number of ethylene oxide of alkyl or alkenyl ether is in the range of 1.5 to 4, preferably 1.5 to 3, and more preferably 1.5 to 2.5. When the average number of added moles is less than 1.5, the crystallinity is high and it is difficult to dissolve in the aqueous phase, which is not preferable. On the other hand, when the average number of added moles exceeds 4, the moisture transpiration suppressing effect and the blocking effect are remarkably reduced, which is not preferable. The generally available polyoxyethylene alkyl or alkenyl ether is a mixture having a very wide distribution centering on the desired degree of polymerization with respect to the number of moles of ethylene oxide added, but the average number of moles added is within the above range. Is important in the present invention.

  Examples of the polyoxyethylene alkyl or alkenyl ether (hereinafter sometimes simply referred to as polyoxyethylene alkyl ether or POE alkyl ether) used in the present invention include polyoxyethylene (2) aralkyl ether and polyoxyethylene (3) aralkyl ether. , Polyoxyethylene (4) aralkyl ether, polyoxyethylene (2) behenyl ether, polyoxyethylene (3) behenyl ether, polyoxyethylene (4) behenyl ether, polyoxyethylene (2) carnerville ether, polyoxyethylene (3) Carnerville ether, polyoxyethylene (4) Carnerville ether, and the like, preferably polyoxyethylene (2) behenyl ether, polyoxyethylene (3) behenyl ether, polio Shiechiren (4) behenyl ether and the like, particularly preferably polyoxyethylene (2) behenyl ether. In addition, as long as the average added mole number of the polyoxyethylene alkyl ether used is in the above range, it is possible to use other than the polyoxyethylene alkyl ethers exemplified above.

  The content of the polyoxyethylene alkyl ether in the external preparation for skin of the present invention is preferably 0.05 to 20% by mass, more preferably 0.1 to 20% by mass, and particularly preferably the total amount of the composition. It is 0.1-10 mass%. If it is in the said range, the moisture transpiration suppression effect and the obstruction | occlusion effect are high, and it can mix | blend easily with an aqueous phase, and is preferable.

  In the external preparation for skin of the present invention, (B) a water-soluble polymer is used. The water-soluble polymer (A) polyoxyethylene alkyl ether is stably dispersed and held in the aqueous phase, and contributes to the moisture evaporation suppression effect and the blocking effect.

  Examples of the water-soluble polymer used in the present invention include a water-soluble cationic polymer, an anionic polymer, a nonionic polymer, and an amphoteric polymer or a bipolar polymer.

  Specific examples of the cationic polymer include poly (dimethyldiallylammonium halide) type cationic polymer, dimethyldiallylammonium halide and acrylamide copolymer cationic polymer, quaternary nitrogen-containing cellulose ether, vinylpyrrolidone dimethyl Examples thereof include cationized products of aminoethyl methacrylate copolymers or condensation products of taroylamine or cocoylamine obtained from polyethylene glycol, epichlorohydrin, propyleneamine and beef tallow fatty acid. Examples of the poly (dimethyldiallylammonium halide) type cationic polymer include those sold by Merck & Co. Inc. of the United States under the trade name “Merquat 100”. Examples of the copolymer-type cationic polymer of dimethyldiallylammonium halide and acrylamide include Merquat 550 (Merquat & Co., Inc.). Examples of condensation products of polyethylene glycol, epichlorohydrin, propyleneamine and taroylamine or cocoylamine include those sold under the trade name Polyquat H and sold by Henkel International Co. be able to. Quaternary nitrogen-containing cellulose ethers are trade names of polymer JR-400 (Polymer JR-400), polymer JR-125 (Polymer JR-125), polymer JR-30M (Polymer JR-30M), and US Union Carbide. Such as those sold by Union Carbide Corp. The cationized vinylpyrrolidone / dimethylaminoethyl methacrylate copolymer is sold by GAF Corp. in the United States under the trade names of Gafquat 755 and Gafquat734.

  Specific examples of the anionic polymer include carboxyvinyl polymer, carboxymethyl cellulose, carrageenan, xanthan gum, polystyrene sulfonate, agar, gatch gum, caraya gum, pectin, alginate salt, poly (acrylic acid), acrylic acid, and alkali of methacrylic acid. Acrylic acid or methacrylic acid derivatives such as metals and ammonium salts can be mentioned.

  Specific examples of nonionic polymers include cellulose ethers (hydroxybutylmethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, ethylhydroxyethylcellulose, hydroxyethylcellulose, etc.), propylene glycol alginate, polyacrylamide, (Na acrylate) / Acryloyldimethyltaurine Na) copolymer, poly (ethylene oxide), polyvinyl alcohol, polyvinylpyrrolidone, hydroxypropyl guar gum, locust bean gum, amylose, hydroxyethyl amylose, hyaluronic acid or its alkali metal salts, starch, starch derivatives and mixtures thereof Etc.

  Specific examples of the amphoteric polymer or the bipolar polymer include octylacrylamide / acrylate / butylaminoethyl methacrylate copolymer, polyquaternium-47, and polyquaternium-43.

  These water-soluble polymers can be used alone or in combination of two or more. Carboxyvinyl polymer, acrylic acid / alkyl methacrylate copolymer, xanthan gum, hydroxypropylmethylcellulose, polyacrylamide, (Na acrylate / acryloyl dimethyl taurine Na) copolymer, hyaluronic acid for ease of application to various dosage forms And alkali metal salts thereof are preferred.

  The content of the water-soluble polymer used in the present invention is preferably 0.01 to 5% by mass, more preferably 0.05 to 3% by mass, based on the total amount of the composition. If it is in the said range, stability of a formulation will be maintained and the outstanding moisture transpiration suppression effect and the obstruction | occlusion effect will be acquired, and it is preferable.

  The component (C) skin active ingredient used in the present invention refers to any activity on the skin, such as a moisturizing effect, skin softening effect, whitening effect, anti-inflammatory effect, antioxidant effect, blood circulation promoting effect, anti-aging effect (anti-aging effect) Wrinkle effect), sebum secretion inhibitory effect and the like. Such an active ingredient is not particularly limited as long as it is various active ingredients used for normal cosmetics, quasi drugs, pharmaceuticals and the like. Examples include plant extracts, anti-inflammatory agents, moisturizers, amino acids, whitening agents, singlet oxygen scavengers, antioxidants, blood circulation promoters, sebum secretion inhibitors, antibacterial agents, keratos and the like.

  As described above, a combination of a water-soluble polymer and a polyoxyethylene alkyl or alkenyl ether having an alkyl group or alkenyl group having 20 to 24 carbon atoms and an average addition mole number of ethylene oxide of 1.5 to 4 is combined. By using the polyoxyethylene alkyl or alkenyl ether, the hydrophobic group (alkyl group or alkenyl group) and the hydrophilic group (ethylene oxide group) interact with each other to suppress moisture transpiration and to exhibit excellent blocking properties. (C) Since the penetration of the skin active ingredient of the invention is promoted, the moisturizing effect of the skin active ingredient, the prevention / improving effect of rough skin, the reduction of skin elasticity / elasticity, the prevention / improving effect of dullness of complexion, excess sebum, Prevention / improvement of conspicuous pores and acne caused by bacteria and abnormal keratinization, prevention / improvement of wrinkle formation, prevention / improvement of stains and freckles Effect, prevention and improvement of such conspicuous and acne pores due to excess sebum, preventing and improving effects such as wrinkle formation is enhanced synergistically, further, a skin external preparation excellent in feeling of use is obtained.

  Among these skin active ingredients, since the present invention has a high moisture transpiration inhibiting effect, the hydrophilic skin active ingredient is retained on the skin for a long time, and the penetration of the skin active ingredient is promoted. Is preferably used.

  Hereinafter, specific examples of the skin active ingredient will be exemplified, but there are some components having a plurality of functions which are described in duplicate. These are merely examples and are not limited.

  Among (C) skin active ingredients used in the present invention, any plant extract that has a medicinal effect on the skin can be used without particular limitation as the plant extract. As a plant extract with excellent moisturizing and firmness, it belongs to the Brassicaceae, Gramineae, Hypericaceae, Ganodermaceae, Gingeraceae, Honeysuckle, Rose, Leguminous, Citrus, Muclenaceae, Yukinoshita, and seaweeds. It is preferable to use 1 type (s) or 2 or more types chosen from the extract from.

  In the present invention, it is not limited with respect to the site used by the plant, and the above-mentioned parts including flower parts, stem parts, leaf parts, seeds, fruits, fruit skins, etc., roots, underground parts such as rhizomes, etc. are used alone or in combination. be able to. In the extraction, the plant itself may be used, or a processed product such as dried or shredded or pulverized may be used.

  As a solvent used when obtaining a plant extract, organic solvents, such as water, a lower alcohol, a higher alcohol, hydrocarbons, or its derivative (s), can be illustrated as a polar solvent. Nonpolar solvents include petroleum ether, aliphatic hydrocarbons having 4 to 8 carbon atoms, halides of aliphatic hydrocarbons having 1 to 2 carbon atoms, aromatic hydrocarbons having 6 to 7 carbon atoms, and the like. It can be illustrated. The extraction method is not particularly limited. Among these plant extracts, those extracted with a polar solvent are preferable, and it is particularly preferable to extract using water or a mixture of water and a lower alcohol such as methanol, ethanol, isopropanol. In this case, the ratio of water and lower alcohol is preferably 0/100 to 70/30 (V / V: volume ratio), more preferably 0/100 to 40/60.

  This plant extract may be used as it is, or may be used as a diluted solution, a concentrated extract, a dry powder by freeze drying, or a paste. Moreover, you may use what made them fermented. When it is prepared as a dry powder, it is preferably used by dissolving it in water or a lower alcohol such as methanol, ethanol or isopropanol containing water in advance, or solubilizing it in a composition containing water.

  The plant of the Brassicaceae family is not particularly limited, but preferably, the Brassica genus is Taasai (B. campestris var. Narinosa), Brassica mustard (B. juncea), Mustard (B. juncea) Takana (B. juncea var. integlifolia), rutabaga (B. napobrassica), oilseed rape (B. napus), Mizuna (B. nipposinica), black mustard (B. nigra), hagoromokanran (B. oleracea var. acephala), ha button (B. oleracea var. acephala), kairan (B. oleracea var. allbograbra), cauliflower (B. oleracea var. botrytis), romanesco (B. oleracea var. botrytis), cabbage (B. oleracea var. capitata), mekabetsu (B. oleracea var. gemmifera), Kohlrabi (B. oleracea var. gongylodes), broccoli (B. oleracea var. italica), Chingensai (B. rapa var. chinensis), Pakchoi (B. rapa var. chinensis), Nozawana (B. rapa v ar. hakabura), Mizuna (B. rapa var. lancinifolia), Brassica (B. rapa var. nippo-oleifera), Chinese cabbage (B. rapa var. pekinensis), Komatsuna (B. rapa var. peruviridis), Turnip (B rapa var. rapa); for Camelina, for C. sativa; for Arthio, for M. incana; for Ionopsidium, for Inopsidium acaule); Rorippa includes R. dubia, R. indica, R. islandica; Draba includes D. aizoidas, Inazuna (D. nemorosa); Aurinia, A. saxatilis; Diplotaxis, D. muralis; Orychophragmus O. violaceus; N. officinale for Nasturtium; C. didymus, C. didymus, C. doymus for Coronapus integrifolis); for Eruca, E. vesicaria; for Sisymbrium, S. irio, S. loeselii, S. officinale, S. officinale (S. orientale); for Thlaspi, for T. arvense; for Lunaria, for L. annua; for Arabidopsis, for Arabidopsis (A. thaliana); for horseradish (Armoracia), horseradish (A. rusticana); for horsetail (Hirschfedia) As the genus Raphanus, the radish (R. sativus), the Japanese radish (R. s. Var. Radicula), the red radish (R. s. Var. Raphanistroides); and the cardamine genus (Cardamine) Are C. flexuosa, C. impatiens, C. parviflora,; Capsella, C. bursa-pastoris; Lobularia L. maritima; for Hesperis, H. matronalis; for Iberis, I. amara, I. sempervirens, candy Tuft (I. umbellata); As for the genus Lepidium, L. apetalum, L. meyenii, L. perfoliatum, pepper (L. sativum) ), Leguminum (L. virginicum); as Malcolmia (M. maritima); as genus Rapistrum (R. rugosum); as genus Alyssum (Alyssum), Examples of A. alpestre, A. alyssoides, A. montanum; Wasabia include wasabi (W. japonica).

  Of these cruciferous plants, the genus Brassica, Dutch genus, Legume genus, Horseradish, and Wasabi are preferred.

  The plant of the family Gramineae is not particularly limited, and preferably, the genus Agropyron includes A. repens, A. ciliare var. Minus, A. tsukushiense var. Transiens; As the genus (Horudeum), barley (H. vulgare), H. murinum; Triticum, wheat (T. aestivum), durum wheat (T. durum); Rye genus (Secale) Are rye (S. cereale); oats (A. sativa) for the genus Avena; A. nuda; O. sativa for the rice genus (Oryza); Coix) is pearl barley (C. lacryma-jobi var. Ma-yuen); genus Miscanthus is ogi (M. sacchariflorus), susuki (M. sinensis); (P. bisulcatum), Houkinu P. scoparium; As Phragmites, P. arundinacea, P. communis; As Phyllostachys, P. pubescens; Saccharum S. officinarum; Sasa, S. palmata; Setaria, S. virides, S. viridis; Corn ) Include maize (Z. meys); and the genus Zakonia includes Z. latifolia.

  Of these gramineous plants, wheat, barley, rye, rice, and maize are preferred.

  Although not particularly limited as a plant of the Hypericaceae family, preferably Hypericum, Hypericum (H. erectum), St. Johns wort (H. perforatum), Willow (H. monogynum), Kinshibai (H. patulum); The genus Garcinia includes mangosteen (G. mangostana), guru (G. atroviridis Griff.ex T. Anders.), Bankamangisu (G. bancana Miq.), Bananomangisu (G. brevirostris Scheff.), Goraka (G cambogia Desr.), Celebes mangosteen (G. celebicaLinn.), Kowa Gamboa (G. cowa Roxb.), Mumunjin (G. dioicaBlume.), Ovano mangosteen (G. dulcis. Kurz.), Akamikandis (G. forbesii King) .), Kangis (G. globulosa Rindl.), Kiminomangisu (G. hgriffithii T. Anders.), Gamboji (G. hauburyi Hook. F.), Hamamangosteen (G. hombroniana Pierre), Mergykangis (G. merguensis Wight) ), Inga Boji (G. morella Desr.), Tsunomangisu (G. nigrolineata Planch.ex T. Anders.), Kobano candis (G. parvifolia Miq.), Button mangosteen (G. prainiana King), Fukugi (G. subelliptica Merrill), Japanese peach (G. xanthochymus Hookf.) And the like.

  Of these plants of the family Hypericaceae, preferably the genus Hypericum and Fuchsia.

  Although it is not particularly limited as a plant of the genus Pleurotus, preferably, Angelonia (A. salicariifolia); Angelica (T. concolor var. Formosana), Hanauri (T. concolor) fournieri); Rehmannia, R. glutinosa Liboschitz Var.purpurea Makino, R. glutinosa Liboschitz, R. piasezkii; Verbascum, velvet musk thapsus) and the like.

  Among these plants of the genus Ligaceae, preferably, the genus Crane is a genus of Crane genus and Dioscus.

  Although it does not specifically limit as a plant of the ginger family, Preferably, ginger (Z. officinale (Willd.) Roscoe), a ginger (Z. mioga (Thumb.) Roscoe); Hanamyoga (Alpinia) As for: Hana Myoga (A. Japonia (Thumb.) Miq), Aonkuma Takekeran (A. intermedia Gagnep.), Iriomotechmatakeran (A. flabellate Ridl.), Tamatakeran (A. formosana K. Schum.) (A. speciosa (Wendl.) K. Schum.), A. boninensis Makino, A. nakaiana Tuyama, A. oxyphylla Miq .; Curcuma (C. longa), C. zedonaria Rosc., C. aeruginosa Roxb., C. alismatifolia Gagnep .; Elettaria, Cardamom (E. cardamomum) Maton) It is.

  Among these ginger family plants, preferably, the genus Ginger, the genus Hanamyo, and the genus Curcuma are mentioned.

  The honeysuckle plant is not particularly limited, but preferably, the genus Abelia is A. serrata, the A. spathulata; and the Lonicera is L. chrysantha. var. crassipes), warbler (L. gracilipes var. glabra), Miyagi warbler (L. gracilipes var. glandulosa), honeysuckle (L. japonica), goldfish (L. morrowii), sea bream (L. sempervirens) The genus Sambucus includes S. chinensis, S. nigra, S. racemosa, S. racemosa ssp. Sieboldiana; Viburnum , Coral (V. awabuki), viburnum (V. dilatum), viburnum (V. erosum var. Punctatum), lynx (V. furcatum), cambo V. opulus var. Calvescens, V. pilicatum var. Tomentosum, V. urceolatum, V. wrghtii; Weigela, W. floribunda, Examples of the genus Zabelia include Z. integrifolia and the like.

  Among these honeysuckle plants, the genus Honeysuckle and Elderberry are preferable.

  Although it does not specifically limit as a plant of the Rosaceae, Preferably, it is a genus Agrimonia, A. nipponica, A. pilosa var. Japonica; Pyracantha, Tachibanamodoki (P angustifolia), P. coccinea, P. crenulata, P. koidzumii, P. fortuneana; Spiraea, S. salicifolia, S. betulifolia Pall. Var. Betulifolia, S. miyabei Koidz. S. japonica, S. thunbergii Siebold ex Blume, S. prunifolia Siebold et , S. chamaedryfolia L. var. Chamaedryfolia, S. media FW Schmidt var. Sericea (Turcz.) Regel ex Maxim. (S. nipponica Maxim. Var. Nipponica), S. dasyantha Bunge, S. cantoniensis Lour., S. blumei G. Don; Potentilla, P. anglica), P. chinensis, P. discolor, P. erecta, P. fruticosa var. Rigida, P. matsumurae, P. matsumurae, P. matsumurae miyabie), snake strawberry (P. sundaica var. robusta); as the genus Strawberry (Fragaria), F. iinumae, white snake strawberry (F. nipponica), safflower snake strawberry (F. nipponica f. rosea), Yakushima shirobana Snake strawberry (F. nipponica var. Yakusimensis), Ezo snake strawberry (F. vesca), Ezo strawberry (F. yezoensis), Dutch strawberry (F. x ananassa), Chile strawberry (F. chiloensis), Virginia F. virginiana; As the genus Geum, there are G. calthaefolium var. Nipponicum, G. pentapetalum, G. japonicum, G. montanum ); Snake strawberry genus (Duchesnea), Snake strawberry (D. chrysantha), Yabu snake strawberry (D. indica); Rubus genus (R. buergeri), Horumui strawberry (R. chamaemorus), Bear strawberry (R . crataegifolius), velvet strawberry (R. corchorifolius), Atlantic yab strawberry (R. fruticosus), blackberry (R. spp.), cinnamon strawberry (R. hirsutus), striped strawberry (R. palmatus var. (R. parvifoius), Kobayofu strawberry (R. pectinellus), Hasunoha strawberry (Rhubus peltatus), Kojiki strawberry (R. sumatranus), Kaji strawberry (R. trifidus); As the genus Sanguisorba, S. hakusanensis, S. officinalis, S. tenuifolia var. Alba, S. tenuifolia var. Grandiflora; Rose genus (Rosa) Western roses (R. centifolia (Rosaceae)), hybrid roses (R. Hybrida (Rosaceae)), ages (R. multiflora Thunberg (Rosaceae)), Naniwaibara (Rosa laevigata), mokowara (Rosa.banksiae), Neubara ( Rosa multiflora, Hermanus (Rosa rugosa), Yamai rose (Rosa sambucina), Rosa pomifera, Rosa moschata, Rosa canina; Prunus, P. persica batsch , Apricot (P. armeniaca l. ), P. mume, P. jamasakura, P. pendula f. Ascendens; Hawthorn (Crataegus) includes C. cuneata, Hawthorn (C. pinnatifida), Hawthorn (C. oxyacantha); as genus Eriobotrya; as loquat (E. japonica); as genus Chaenomeles; as C. sinensis; as genus Malus as apple (Malus pumila (Rosaceae)), M. halliana, Kerria, K. japonica; Sorbus, S. alnifolia, S. aucuparia, S. commixta ), S. japonica, S. matsumurana, S. sambucifolia.

  Among these Rosaceae plants, preferably, the genus Kimizuki, Waremomo, Hawthorn, and Sakura are included.

  As leguminous plants, soybeans (G. max subsp. Max), peas (G. max subsp. Soja); genus Lathyrus (L. japonicus), L. odoratus, L. latifolius; Albizia, A. julibrissin; Sophora, Cl. (S. flavewscens), Isofuji (S. tomentosa); Strongylodon, J. honeysuckle (S. macrobotrys); Styphnolobium, S. japonicum, S. japonicum var. pendulum; Trifolium For example, safflower clover (T. incarnatum), purple clover (T. pratense), white clover (T. repens), cattle clover (T. burchellianum); For example, Vicia angustifolia, V. faba, V. hirsuta, V. tetrasperma, V. unijuga; Vigna, V. radiata), azuki bean (V. angularis); Wisteria, W. brachybotrys, W. floribunda; Arachis, peanut (A. hypogaea); Cicer) is chickpea (C. arietinum); Aspalathus is A. linearis; Glycyrrhiza is Spanish licorice (G. glabra), Ural licorice (G. uralensis) Astragalus includes A. membranaceus, A. sinicus; Lens includes L. culinaris; Pesu m) for peas (P. sativum); for bean genus (Phaseolus), safflower bean (P. coccineus), lima bean (P. lunatus), bean (P. vulgaris); Examples thereof include P. lobata and P. mirifica.

  Among these leguminous plants, preferably, soybean genus, genus genus, broad bean genus, licorice genus, cowpea genus, pea genus, and common bean genus.

  Citrus genus (C. unshiu Marcov), C. tangerina Tanaka, Cs erythrosa Tanaka, citrus (C. aurantium L subsp. Nobilis Makino), Daidai (C. aurantium L., var. Daidai Makino), Malbuskan (C. medica L), Natsumikan (C. Natsudaidai Hayata), Zavon (C. grandis Osbeck), Yuzu (C. Junos Tanaka), Ponkan (C. reticulata) Blanco), Lemon (C. limon Burmann), Karatachi (C. trifoliata L), Grapefruit (C. paradisi Macf.); Fortunella, Fortunella, Malkinkan (F. japonica swingle); Salamander (Xanthoxyum) ) As a salamander (X. piperitum DC); as a genus Euodia, as a eugenia (Euodia rutaecarpa Hook. Fil et Thoms.); As a genus Fragara as an F. mant e churica Honda); As for Orixa, as for O. japonica Thunb; As for Skimmia, as S. japonica Thunb; As for Poncirus, as P. trifoliata ) And the like.

  Of these citrus plants, preferably, citrus and kumquat are used.

  As magnoliaceae plants, as Liriodendron, as Liriodendron; L. tulipifera; as Magnolia, Magnolia, M. denudata, Taisanboku (M. grandiflora), magnolia (M. liliflora), As M. kobus, M. obovata, M. salicifolia, M. stellata; Michelia, M. compressa, M. figo ) And the like.

  Of these magnoliaceae plants, the genus Lilium and the magnolia are preferable.

  As for the plant of the family Sphagnumaceae, the genus Astilbe includes A. microphylla, A. thunbergii var. Thunbergii, A. thunbergii var. Congesta; Bergenia For example, Himalayan Yukinoshita (B. stracheyi), Iwajikasai (B. emeiensis), Siberian Yukinoshita (B. cordifolia), Atsuba Iwajika (B. crassifolia), Indian Rock Ivy (B. purpurascens), Chinese cabbage (B scopulosa); As the genus Chrysosplenium, there are C. album, C. kiotense, C. kiotense forma xanthandrum, C. grayanum, Y. japonicum); The genus Deutzia includes D. crenata, D. crenata f. plenta, D. gracilis, Malva As the genus Hydrangea, there are H. arborescens, H. hirta, H. luteovenosa, H. macrophylla, H. paniculata ), H. petiolaris, H. scandens, H. serrata; Mitella, M. pauciflora; Parnassia, P. foliosa var. nummularia), P. palustris var. multiseta, P. palustris var. palustris; as Penthorum, as P. chinense; as Philadelphus , P. satsumi; Ribes include R. ambiguum, R. fasciculatum, Komatsutake R. japonicum; Rodgersia for R. podophylla; Saxifraga for S. aizoides, S. aspera (S. fortunei var. Suwoensis), S. stellaris, S. stolonifera; Schixophragma includes S. hydrangeoides and the like.

  Of these plants belonging to the family Saxifragaceae, the genus Himalayan Yukinoshita and Yukinoshita are preferred. Roots and stems are mainly used.

  As the seaweed, as the seaweed belonging to the family Lamiaceae (Ulvaceae), the genus Aosa (Ulva), the genus Aonori (Enteromorpha), the genus Kurohae (Ulvaria) and the like are used, preferably the genus Aosa and the genus Aonori. Examples of the seaweed belonging to the family Gracilariaceae used in the present invention include the genus Gracilaria, the genus Gracilariopsis, the genus Tylotus, and the genus Gelidiopsis, and preferably the genus Ogonori and Culsilamo It is a genus. Examples of the seaweed belonging to the family Lepidoptera (Gelidiaceae) used in the present invention include the genus Gelidium, the genus Beckerella, the genus Pterocladia, the genus Acanthopeltis, and preferably the genus Maca. As the seaweed belonging to the family Solieriaceae used in the present invention, the genus Eucheuma, Meristotheca, Solieria, Turnerella, etc. are used, preferably the genus Kirinsai, is there. The seaweeds belonging to the family Laminariaceae used in the present invention include the genus Laminaria, the genus Klollum (Kjellmaniella), the genus Ecklonia, the genus Eisenia, the genus Eckloniopsis and the genus Agarum. Genus Costaria, Arthrothamnus, Hedophyllum and the like, preferably the genus Kombu, the genus Trolocomb, the genus Kajime, the genus Alame, and the genus Antokume. Examples of seaweeds belonging to the family Aariaceae (Alariaceae) used in the present invention include the genus Undaria and the genus Alaria. The seaweeds belonging to the Sargassaceae used in the present invention include the genus Hizikia, the genus Sargassum, the genus Turbinaria, the Cystoseira, the Myagropsis, and the Coccophora. And the like, preferably the genus Hijiki and the genus Honda. As the seaweeds belonging to the family Fucaceae used in the present invention, Ascophyllum, Asperus genus (Fucus), Ezoishige (Pelvetia) and the like are used, with Ascophyllum and Hibamata being preferred. As the seaweed belonging to the family Funoriaceae (Gloiopeltidaceae) used in the present invention, the genus Funori (Gloiopeltis) is used. As the seaweed belonging to the family Monostromataceae used in the present invention, genus Humanostroma, genus Kornmannia and the like are used, and preferably the genus Humanexa. As the seaweed belonging to the family Milliaceae (Codiaceae) used in the present invention, Codium is used. As the seaweed belonging to the family Bobaceae (Bangiaceae) used in the present invention, the genus Amori (Porphyra), the genus Boeni (Bangia) and the like are used, and the genus Amori is preferred. Examples of the seaweed belonging to the family Gigartinaceae used in the present invention include the genus Gingartina, the genus Rhodoglossum, and the genus Chondrus, preferably the genus Suginori and the genus Tsunogata. As seaweeds belonging to the family Bonnemaisoniaceae used in the present invention, Asparagopsis, Bonnemaisonia and the like are used, and preferably the genus Kakenori. As the seaweed belonging to the family Hypneaceae used in the present invention, the genus Hypnea is used. Examples of the seaweed belonging to the Chordariaceae family used in the present invention include the genus Pinus (Analipus) and the genus Cladosiphon. As the seaweed belonging to the family Nematocystaceae used in the present invention, the genus Nematocystis is used. Examples of the seaweed belonging to the family Durvilleaceae used in the present invention include the genus Durvillea. As the seaweed belonging to the Lessoniaceae used in the present invention, the genus Lesonia, the genus Macrocystis and the like are used. As the seaweed belonging to the family Rhodymeniaceae used in the present invention, the genus Rhodymenia and the like are used.

  These plant extracts can be used alone or in combination of two or more. The content of the plant extract used in the present invention is preferably 0.0001 to 5% by mass, more preferably 0.002 to 3% by mass, and even more preferably 0 as a solid content conversion amount with respect to the total amount of the composition. 0.003 to 1% by mass. If it is in the said range, since the effect of a plant extract is fully exhibited by the synergistic effect with the obstruction | occlusion property of the composition containing a component (A) and (B), it is preferable.

  Among (C) skin active ingredients used in the present invention, anti-inflammatory agents include γ-amino-β-hydroxybutyric acid or a salt thereof, γ-aminobutyric acid or a salt thereof, L-carnitine or a salt thereof, glycyrrhizic acid or Examples thereof include salts thereof, glycyrrhetinic acid or salts thereof, isopropylaminocaproic acid or salts thereof, allantoin, lysozyme chloride, guaiazulene, methyl salicylate, and γ-oryzanol. Of these, preferably γ-amino-β-hydroxybutyric acid or a salt thereof, γ-aminobutyric acid or a salt thereof, L-carnitine or a salt thereof, diisopropylamine dichloroacetate, glycyrrhizic acid or a salt thereof, glycyrrhetinic acid or a salt thereof Allantoin, lysozyme chloride, methyl salicylate, especially γ-amino-β-hydroxybutyric acid or a salt thereof, γ-aminobutyric acid or a salt thereof, L-carnitine or a salt thereof, diisopropylamine dichloroacetate, glycyrrhizic acid or a salt thereof preferable.

  The salt is not particularly limited. For example, alkali metals such as sodium and potassium, inorganic salts such as calcium, magnesium, aluminum and zinc, organic amines such as ammonia, monoethanolamine, diethanolamine and triethanolamine, arginine, Examples include organic salts such as basic amino acids such as lysine, and one or more of these can be used in combination. Sodium, potassium, triethanolamine, and arginine salts are preferred because they are readily available on the market.

  The content of these anti-inflammatory agents in the external preparation for skin of the present invention is preferably 0.001 to 5% by mass, more preferably 0.01 to 2% by mass, and particularly preferably 0. 0% by mass relative to the total amount of the composition. 01 to 1% by mass. If it is in the said range, the rough skin improvement effect, the moisture transpiration suppression effect, and the obstruction | occlusion effect are high, and it can mix | blend easily with an aqueous phase, and is preferable.

  Among the skin active ingredients (C) used in the invention, as a moisturizer, for example, N-methyl-L-serine, chondroitin sulfate or a salt thereof, collagen (average molecular weight: 50,000 to 6 million), water-soluble collagen, Examples include hydrolyzed collagen (average molecular weight: 100 to 9000), royal jelly extract, lactic acid or a salt thereof, elastin, chitin, chitosan, urea, pyrrolidone carboxylic acid or a salt thereof, and the like. Among these, N-methyl-L-serine, chondroitin sulfate or a salt thereof, water-soluble collagen, hydrolyzed collagen (average molecular weight: 100 to 9000), royal jelly extract, lactic acid or a salt thereof, particularly N- Methyl-L-serine, water-soluble collagen, and hydrolyzed collagen (average molecular weight: 100 to 9000) are preferred.

  The salt is not particularly limited. For example, alkali metals such as sodium and potassium, inorganic salts such as calcium, magnesium, aluminum and zinc, organic amines such as ammonia, monoethanolamine, diethanolamine and triethanolamine, arginine, Examples include organic salts such as basic amino acids such as lysine, and one or more of these can be used in combination. Sodium, potassium, triethanolamine, and arginine salts are preferred because they are readily available on the market.

  The content of these anti-inflammatory agents in the external preparation for skin of the present invention is preferably from 0.001 to 20% by mass, more preferably from 0.01 to 15% by mass, particularly preferably 0, based on the total amount of the composition. 0.01 to 10% by mass. If it is in the said range, a moisturizing effect, a moisture transpiration inhibitory effect, and an obstruction | occlusion effect are high, and it can mix | blend easily with an aqueous phase and is preferable.

  Among (C) skin active ingredients used in the present invention, examples of amino acids or salts thereof include ornithine, tryptophan, lysine, arginine, histidine, canavanine, glutamic acid, aspartic acid, serine, alanine, glycine, leucine, isoleucine, Proline, threonine, valine, methionine, cystine, cysteine, hydroxyproline, phenylalanine, tyrosine, hydroxylysine, trimethylglycine, sodium aspartate, potassium aspartate, magnesium aspartate, calcium aspartate, sodium glutamate, potassium glutamate, magnesium glutamate, Calcium glutamate, glutamate hydrochloride, cysteine hydrochloride, histidine hydrochloride, histidine acetate, hist Phosphate, lysine hydrochloride, lysine acetate, ornithine hydrochloride, ornithine acetate, tryptophan hydrochloride, arginine-glutamate, ornithine-glutamate, lysine-glutamate, lysine-aspartate, ornithine-aspartate , Ε-aminocaproic acid and the like. Of these, arginine, lysine, hydroxylysine, histidine or a salt thereof is preferable, and arginine or a salt thereof is particularly preferable.

These amino acids or salts thereof can be used singly or in combination of two or more. It is preferably contained in the skin external preparation of the present invention in an amount of 0.0001 to 15% by mass, particularly 0.001 to 10%. It is preferable to contain it in an amount of 0.01 to 8% by mass because it is excellent in the moisturizing effect, the effect of preventing and improving wrinkle formation, the effect of preventing and improving rough skin, the feeling of use and the stability.

  Of the skin active ingredients (C) used in the present invention, the whitening agent is not particularly limited as long as it is used in normal cosmetics, for example, L-ascorbic acid or a derivative thereof, rhododendrol or a derivative thereof. Arbutin, tranexamic acid or a derivative thereof, 4-methoxysalicylic acid or a salt thereof, and the like.

  Ascorbic acid or a derivative thereof is not particularly limited. For example, ascorbic acid or a salt thereof, ascorbic acid ester or a salt thereof, ascorbic acid phosphate or a salt thereof, ascorbic acid sulfate or a salt thereof, ascorbic acid Examples thereof include glucoside (2-O-α-D-glucopyranosyl-L-ascorbic acid) or a salt thereof, glucosamine ascorbate, dehydroascorbic acid or a salt thereof, and the like. Of these, preferably ascorbic acid or a salt thereof, ascorbic acid ester or a salt thereof, ascorbic acid phosphate or a salt thereof, ascorbic acid sulfate or a salt thereof, ascorbic acid 2-glucoside (2-O-α-D-glucopyranosyl) -L-ascorbic acid) or a salt thereof, and particularly preferably ascorbic acid or a salt thereof, and ascorbic acid 2-glucoside (2-O-α-D-glucopyranosyl-L-ascorbic acid).

  The rhododendrol or a derivative thereof is not particularly limited. For example, rhododendrol [4- (p-hydroxyphenyl) -2-butanol], acetyl rhododendrol, hexanoyl rhododendrol, octanoyl Rhododendrol, dodecanoyl rhododendrol, tetradecanoyl rhododendrol, hexadecanoyl rhododendrol, octadecanoyl rhododendrol, 4- (3-acetoxybutyl) phenyl acetate, 4- (3-propanoyloxy Acylated rhododendrol such as butyl) phenylpropanoate, 4- (3-octanoyloxybutyl) phenyloctanoate, 4- (3-palmitoyloxybutyl) phenylpalmitate, 4- (3-methoxybutyl) Phenol, 4- (3-E Rhododendrol alkyl ethers such as xoxybutyl) phenol, 4- (3-octyloxybutyl) phenol, rhododendrol-D-glucoside (α or β-form), rhododendrol-D-galactoside (α or β-form) And rhododendrol-D-xyloside (α or β form), rhododendrol-D-maltoside (α or β form) and the like. Of these, rhododendrol and acylated rhododendrol are preferable, and rhododendrol is particularly preferable.

  The tranexamic acid or its derivative is not particularly limited, and examples thereof include tranexamic acid or a salt thereof, trans-4- (trans-aminomethylcyclohexanecarbonyl) aminomethylcyclohexanecarboxylic acid, trans-4-aminomethylcyclohexane. Carboxylic acid 4′-hydroxyphenyl ester, 2- (trans-4-aminomethylcyclohexylcarbonyloxy) -5-hydroxybenzoic acid or a salt thereof, trans-4-aminomethylcyclohexanecarboxylic acid methylamide or a salt thereof, trans-4- (P-methoxyvinzoyl) aminomethylcyclohexanecarboxylic acid or a salt thereof, trans-4-guanidinomethylcyclohexanecarboxylic acid or a salt thereof, and the like. Of these, tranexamic acid or a salt thereof is preferred.

  The salt is not particularly limited. For example, alkali metals such as sodium and potassium, inorganic salts such as calcium, magnesium, aluminum and zinc, organic amines such as ammonia, monoethanolamine, diethanolamine and triethanolamine, arginine, Examples include organic salts such as basic amino acids such as lysine, and one or more of these can be used in combination. Sodium, potassium, triethanolamine, and arginine salts are preferred because they are readily available on the market.

  These whitening agents can be used alone or in combination of two or more. From the point of whitening effect, emulsion stability and feeling of use, 0.01 to 30% by mass is contained in the skin external preparation of the present invention. In particular, when contained in an amount of 0.01 to 10% by mass, and further 0.01 to 5% by mass, a sufficient whitening effect can be obtained, and the feeling in use and the stability are excellent, which is preferable.

  Among the component (C) used in the present invention, examples of the singlet oxygen scavenger or antioxidant include α-carotene, β-carotene, γ-carotene, lycopene, cryptoxanthine, lutein, zeaxanthin, isoseaxanthin, rhodoxanthin, and capsanthin. , Carotenoids such as crocetin; 1,4-diazacyclooctane, 2,5-dimethylfuran, 2-methylfuran, 2,5-diphenylfuran, 1,3-diphenylisobenzofuran, α-tocopherol, β-tocopherol, γ-tocopherol , D tocopherol, histidine, tryptophan, methionine, alanine or alkyl ester thereof; dibutylhydroxytoluene, butylhydroxyanisole, ascorbic acid, tannic acid, epicatechin, epicacatechin, epicatechin gallate, et Tannins such as Caro gallate, flavonoids such as rutin and the like. Of these, carotene, ascorbic acid, tannic acid, epicatechin gallate, and epicarotate gallate are preferred.

  These singlet oxygen scavengers or antioxidants can be used singly or in combination of two or more, and are preferably contained in the skin external preparation of the present invention in an amount of 0.001 to 5 mass%, particularly 0. When it is contained in an amount of 0.01 to 2% by mass, and further 0.01 to 1% by mass, a high wrinkle formation preventing / improving effect can be obtained, and it is preferable in terms of feeling in use and stability.

  Among the component (C) skin active ingredient used in the present invention, examples of the blood circulation promoter include α-tocopherol, β-tocopherol, γ-tocopherol, d-tocopherol, nicotinamide, methyl nicotinate and the like. Of these, nicotinamide and methyl nicotinate are particularly preferable.

  These blood circulation promoters can be used alone or in combination of two or more, and are preferably contained in the skin external preparation of the present invention in an amount of 0.001 to 10% by mass, particularly 0.01 to 5% by mass. %, Further 0.05 to 3% by mass, prevention and improvement effect of skin elasticity, weakness of skin, dullness of complexion, etc., moisturizing effect, prevention and improvement effect of rough skin, prevention and improvement effect of wrinkle formation, The effect of preventing and improving spots and freckles is enhanced, and the use feeling and stability are excellent, which is preferable.

  Among the component (C) skin active ingredient used in the present invention, as sebum secretion inhibitor, oxendron, 17-α-methyl-β-nortestosterone, chromadianone acetate, cyproterone acetate, spironolactone, hydroxyflutamide, estradiol , Ethinylestradiol, zinc sulfocolate, zinc oxide, aluminum hydroxychloride, allantoin dihydroxyaluminum, vitamin B6, 13-cis-retinoic acid, vitamin E, glycyrrhetinic acid, salicylic acid, nicotinic acid, calcium pantothenate, dipotassium azelate, 10- Examples thereof include hydroxyundecanoic acid and 12-hydroxystearic acid. Of these, vitamin B6, glycyrrhetinic acid, salicylic acid, nicotinic acid, calcium pantothenate, and dipotassium azelate are preferred, with vitamin B6, glycyrrhetinic acid, salicylic acid, and nicotinic acid being particularly preferred.

  These sebum secretion inhibitors can be used singly or in combination of two or more, and are preferably contained in the external preparation for skin of the present invention in an amount of 0.01 to 10% by mass, particularly 0.1 to 5%. When it is contained by mass%, the effect of preventing / ameliorating acne, the effect of suppressing the conspicuous pores and the effect of beautifying the skin are enhanced, and it is excellent in the feeling of use and stability, which is preferable.

  Among (C) skin active ingredients used in the present invention, examples of antibacterial agents include sulfur, triclosan, trichlorocarbanilide, chlorhexine hydrochloride, benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride, and benzalkonium alkyl phosphate. , Isopropylmethylphenol, benzoic acid, photosensitizer 201 and resorcin. Of these, isopropylmethylphenol is particularly preferred. When using these antibacterial agents, it is preferable to contain 0.0001-5 mass%, especially 0.001-2 mass%, and also 0.01-1 mass% in the skin external preparation of this invention.

  Of the component (C) skin active ingredient used in the present invention, examples of the keratin include salicylic acid, N-acetylcysteine, lactic acid, citric acid, succinic acid, malic acid, alkylamine oxide and benzoyl peroxide. It is done. Of these, salicylic acid and citric acid are particularly preferred. When using these keratins, it is preferable to contain 0.01-10 mass%, especially 0.1-1 mass% in the skin external preparation of this invention.

  The skin external preparation of the present invention is a composition in which the water phase is a continuous phase, for example, an aqueous solution composition, an oil-in-water emulsion composition containing water in the continuous phase, from the viewpoint of obtaining a moisture transpiration suppressing effect and a good feeling of use. A W / O / W emulsion composition or the like is preferable.

  The amount of water in the external preparation for skin of the present invention is not limited as long as the aqueous solution or continuous phase can form an aqueous phase O / W or W / O / W emulsion system, and is preferably 10% by mass or more. 15 mass% or more is more preferable, and 20 mass% or more is especially preferable.

  In order to enhance the solubility of the polyoxyethylene alkyl ether in the aqueous phase, it is preferable to further use a polyhydric alcohol in the skin external preparation of the present invention. Preferred polyhydric alcohols include ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol (average molecular weight less than 1000), propylene glycol, dipropylene glycol, polypropylene glycol (average molecular weight: less than 1000), isoprene glycol, and 1,3-butylene. And glycols such as glycol; glycerin, diglycerin, polyglycerin and the like.

  The external preparation for skin of the present invention includes, in addition to the essential components described above, higher alcohols, fatty acids, esters, sterols, sterol fatty acid esters, hydrocarbons, fats and oils as long as the object of the present invention is not impaired. , Silicone oils, antioxidants, antibacterial and antiseptics, insect repellents, salts, chelating agents, neutralizing agents, pH adjusting agents, fragrances and the like can be blended.

  The dosage form of the external preparation for skin of the present invention is not particularly limited, and is prepared as a liquid, emulsion, gel, spray, mousse or the like.

  There is no restriction | limiting in particular as a use of the skin external preparation of this invention, It can use suitably for cosmetics, a pharmaceutical, a quasi-drug, etc. Specifically, hair cosmetics such as shampoos, rinses and conditioners, face wash, cleansing cosmetics, lotions, emulsions, beauty creams, base cosmetics, sunscreen cosmetics, packs, massage cosmetics and other skin cosmetics, It can be suitably used as an external medicine such as an ointment or cream containing various drugs. In particular, since the external preparation for skin of the present invention has a high moisture-occluding effect, it is preferably used as a type of external preparation for skin that is not washed away and is retained on the skin. It is suitable for use as a cosmetic for a moisturizing coat with a good feeling of use.

EXAMPLES Hereinafter, although an Example and a comparative example are given and this invention is demonstrated further more concretely, this invention is not restrict | limited to the following Example. In addition, the amount% of each component is mass%.
The plant extract used in the following examples will be described.
In addition, Examples 19-29 and 36 are reference examples, and are not included in the scope of claims.

Fire thorn extract This is an extract of fire thorn fruit belonging to the genus Pyracantha. As a method for producing the fire thorn extract, 5.00 g of dried fire thorn fruit was immersed in 50 mL of hot water at 90 ° C., boiled for 3 hours and filtered, and the resulting extract was subjected to Diaion HP-20 (Mitsubishi). After loading onto a column (φ3 cm × 11 cm, Vt = 80 mL) of Kasei Kogyo Co., Ltd., it was washed with 800 mL of 10% ethanol aqueous solution. Subsequently, elution was carried out with 400 mL of 40% ethanol aqueous solution, and the eluate was concentrated under reduced pressure and then freeze-dried to obtain 1.02 g of a solid. To this solid, 17.34 g of glycerin and 2.04 g of purified water were added to obtain an extract having a solid content of 5%.

Atsubaiwa Chinese cabbage extract This is an extract of rhizome of Atsubaiwa Chinese cabbage belonging to the genus Himalaya Yukinoshita. As a method for producing Atsuba Ichika Chinese cabbage, 50 g of Rhizome of Atsuha Ichika Chinese cabbage was digested in 250 mL of water at a temperature of 40-50 ° C. and filtered, and then the residue was digested in the same manner several times and extracted 1.5 L of liquid was obtained. 100 mL of purified water was added to the residue concentrated under reduced pressure, and the mixture was aged for 1 week, and then insoluble matters were filtered off. This extract was concentrated again under reduced pressure, and then adjusted by adding 1,3-butylene glycol to obtain an extract solution having a solid content of 1% by mass.

Honoki extract An extract of the cypress bark belonging to the genus Magnolia. As a honoki extract, Honoki Liquid K (solid content 0.175%) manufactured by Ichimaru Falcos was used.

Daidai Extract An extract of Daidai's peel (spruce) belonging to the genus Citrus mandarin. As the Daidai extract, Tochi Liquid B (solid content 2%) manufactured by Ichimaru Falcos was used.

Barley extract This is an extract of seeds (Yokuinin) belonging to the genus Juzdama, except for the bark of the barley. As the pearl barley extract, Yokuinin extract BG-S (solid content 0.3%) manufactured by Maruzen Pharmaceutical Co., Ltd. was used.

Wheat germ extract An extract of wheat germ belonging to the genus Wheat. As a wheat germ extract, Clariskin (solid content 11.7%) manufactured by Silab was used.

Soybean extract It is a fermented lactic acid bacterium of soybean (soy milk) belonging to the leguminous soybean genus. As the soybean extract, a soymilk fermented liquid (solid content 2%) manufactured by Sansho Pharmaceutical Co., Ltd. was used.

Hypericum extract It is an extract of Hypericum that belongs to the genus Hypericum. As the Hypericum extract, Falco Rex and Hypericum B (manufactured by a solid content of 0.85%) manufactured by Ichimaru Falcos were used.

Diou extract This is an extract of the roots of Acagios and Caesioea, which belongs to the genus Dinoceae. Diou extract BG-J (solid content 3%) was used as Diou extract.

Ghetto extract It is an extract of ghetto leaves (moon peach leaves) belonging to the genus Gingeraceae. As the ghetto extract, Moon peach leaf extract BG (solid content 3%) manufactured by Maruzen Pharmaceutical Co., Ltd. was used.

Seaweed extract It is a mixed extract of seaweeds belonging to the genus Hibamata, Kombu, Kombu, Suginori, Tsunomata, and Sugiori. As the seaweed extract, a seaweed extract M (solid content 5.9%) manufactured by Maruzen Pharmaceutical Co., Ltd. was used.

Apricot extract An extract of apricot seeds (Kyonin) belonging to the genus Rosaceae. As an apricot extract, Kyonin extract LA (solid content 1.7%) was used.

Honeysuckle extract An extract of the honeysuckle flower bud belonging to the genus Honeysuckle family. As the honeysuckle extract, the goldfish extract-J (solid content 3.5%) manufactured by Maruzen Pharmaceutical Co., Ltd. was used.

Dutch mustard extract It is an extract of Dutch mustard that belongs to the Brassicaceae genus Galapidae. Water cress-KB (3% in terms of solid content) manufactured by Silab was used as the Dutch mustard extract.

[Test 1] Occlusion effect test 100 μl each of the preparations of Reference Examples 1 to 7, Reference Comparative Examples 1 to 4, Reference Example 1 and Comparative Examples 1 and 2 shown in Tables 1 and 2 were added to a hydrophilic membrane filter (MF-). Millipore GSWP02500, manufactured by Nihon Millipore Corporation; cut to a pore size of 0.22 μm and a filter diameter of 15 mm and used) and dried sufficiently on a hot plate at 37 ° C. to prepare a sample dry membrane filter. Put 5g of pure water into the cell, cover with the sample dry membrane filter, and change the weight of the sample after 1, 3, 5, 7, 12, 18, 24 hours at 30% humidity and 30 ° C. It was measured. The slope of the change in weight was calculated by the least square method (nX + m; X is time h), and the moisture evaporation rate (unit: mg / h) was plotted as an absolute value. The average value of three times for each sample was determined. In addition, transpiration was suppressed as the moisture transpiration rate was smaller. The test results are shown in Tables 1 and 2. From Tables 1 and 2, polyoxyethylene alkyl or alkenyl ethers having an alkyl group or alkenyl group having 20 to 24 carbon atoms and an average addition mole number of ethylene oxide of 1.5 to 4, particularly an average addition mole of ethylene oxide. It can be seen that an excellent blocking effect can be obtained by the combined use of polyoxyethylene behenyl ether having a number of 2 and a water-soluble polymer.
It can also be seen that the moisture transpiration inhibiting effect is maintained even when the skin active ingredient is used in combination.

[Test 2] Combination test of POE alkyl ether and skin active ingredient The weight changes of the samples of Examples 2 to 29 and Comparative Examples 3 to 30 described in Tables 3 to 8 were measured under the same conditions as in Test 1, The moisture transpiration rate was determined. In addition, five panelists for each evaluation item were prepared for each evaluation item, and the panelists actually used the formulation. Regarding “moisturizing feeling after application”, “feeling of stickiness the next morning”, and “non-stickiness at application” Evaluation was performed according to the evaluation criteria, and the average score was described.
The preparations of Examples 19 to 29 and Comparative Examples 20 to 30 were also evaluated twice a day (morning and night) for two months. The “skin prevention / improvement effect on rough skin”, “prevention / improvement effect on conspicuous pores and acne”, and “prevention / improvement effect on spots and freckles” were evaluated according to the following evaluation criteria, and the average score was described.
The results are shown in Tables 3 to 8. From Table 3 to Table 8, in addition to the component (A) and the component (B), by adding a skin active ingredient, the occlusion effect, moisturizing feeling, stickiness, non-stickiness, etc. can be synergistically improved. Recognize.

[Panel evaluation criteria]
Evaluation criteria Score It seems that the effect is high 5
The effect is felt 4
The effect is somewhat felt 3
I feel little effect 2
The effect is not felt 1

[Test 3] Concentration Dependence of Blocking Effect of POE Alkyl Ether The weight changes of the samples of Examples 30 to 35 and Comparative Examples 31 to 34 shown in Table 9 were measured under the same conditions as in Test 1, and the water transpiration rate was determined. Asked. Further, in the same manner as in Test 2, sensory evaluation was performed regarding “moisturizing feeling after application”, “feeling of the next morning”, and “no stickiness at the time of application”. The results are shown in Table 9. From Table 9, it can be seen that by adding a skin active ingredient in addition to the components (A) and (B), the occlusion effect, moisturizing feeling, stickiness, non-stickiness and the like are synergistically improved. In Comparative Examples 33 and 34, precipitation of POE alkyl ether was observed, and sensory evaluation was not performed.

[Test 4] Change in stratum corneum moisture and transdermal moisture transpiration due to layering For 8 expert panelists, mark the inside of the forearm 2x4 cm and use the same 3 basic cosmetics on the market in advance (lotion , Emulsion, cream), and then night pack cosmetic (test product, Table 10 below) was applied at 1.25 μl / cm ² . In addition, what applied only non-application | coating and 3 cosmetics was tested as a comparison.
Before application, 30 minutes after application, 3 hours after application, and 7 hours after application, the stratum corneum water content is measured with Skicon-200EX (IBS), and the transdermal water evaporation is measured with Tewameter MPA580 (Courage + Khazaka). (Measurement conditions: 22 ± 1 ° C., RH 50% ± 5%).
These results are shown in FIGS. 1 and 2, respectively. In FIGS. 1 and 2, the non-application means that neither basic cosmetics nor night pack cosmetics are applied, three articles apply only three basic cosmetics, and three articles + night packs are basic. 3 cosmetic products are applied and then night pack cosmetic is applied.

[Table 10]
Ingredient Mass%
Polyoxyethylene (2) behenyl ether 1
Glycerin 10
Dipropylene glycol 10
Polyethylene glycol 4000 5
Squalane 7
1,3-butylene glycol 2
(Capryl / Caprin / Myristine / Stearic acid) Triglyceryl 1
PEG-60 hydrogenated castor oil 1
Carboxyvinyl polymer * 1 0.4
Xanthan gum * 2 0.2
Sodium hyaluronate 0.01
10% potassium hydroxide 2
Soybean extract (manufactured by Sansho Pharmaceutical Co., Ltd .: fermented soymilk) 0.1
Honeysuckle extract (manufactured by Maruzen Pharmaceutical Co., Ltd .: goldfish extract-J) 0.1
Dutch mustard extract (manufactured by Silab: WaterCress-KB) 0.1
Ghetto extract (manufactured by Maruzen Pharmaceutical Co., Ltd .: Moon peach leaf extract BG) 0.1
Seaweed extract (Maruzen Pharmaceutical Co., Ltd .: Seaweed Extract M) 0.1
Edetate 0.03
Phenoxyethanol 0.35
Residual amount of water * 1: Shintalen K (manufactured by Wako Pure Chemical Industries, Ltd.)
* 2: Celtrol (manufactured by Kelco)

  After application with three basic foundation cosmetics (skin lotion, milky lotion, cream), and using a night pack cosmetic containing the component (A), component (B) and component (C) of the present invention. It was found that a high amount of stratum corneum moisture could be retained after 7 hours.

[Test 5] Change in water content of stratum corneum with respect to artificial rough skin For artificial panelists, artificial rough skin was prepared according to the method of Kawashima et al. (Nichikai, 117 (3), pages 275-284, 2007) ( Attach a cup (diameter 3.5 cm) to the bent side of the forearm, add 6 ml of acetone: ether (content ratio 1: 1), remove the solvent after 20 minutes and volatilize, then add 10 ml of distilled water 5 minutes later, the water was removed, and the same treatment was performed on the same site the next day.)
The artificial rough skin site was marked, and the cream shown in Table 11 was applied twice a day (morning and night), an appropriate amount of artificial rough skin was created, and then applied for 6 days.
The stratum corneum water content was measured with Skicon-200EX (manufactured by IBS) before and after rough skin creation (2nd day), 3 days after cream use, and 6 days after cream use (measurement conditions). : 22 ± 1 ° C., RH 50% ± 5%). Based on the measured value of the stratum corneum moisture after rough skin creation, the difference from the stratum corneum moisture on the 3rd and 6th days of cream use is defined as the stratum corneum moisture change (ΔμS). These results are shown in Table 11 together. The larger the value of the stratum corneum moisture content change amount (ΔμS), the higher the improvement effect.

  It can be seen that the stratum corneum water content is synergistically improved by adding γ-amino-β-hydroxybutyric acid as component (C) in addition to component (A) and component (B). In particular, regarding the stratum corneum moisture content, a significant improvement effect was observed by using the component (A) as compared with the preparation containing the component (C). This is because the component (C) acts inside the skin in a state where the epidermal lipid and water-soluble components are forcibly removed by the artificial rough skin treatment, and the component (A) is the surface of the epidermis. By covering the skin and preventing transpiration, it may be possible to lead the skin state to a better state.

  The formulation example of the skin external preparation of this invention is given to the following. Both are expected to have excellent occlusive properties and synergistic effects of skin active ingredients.

Formulation Example 1 (Lotion)
Ingredient Mass%
Polyoxyethylene (2) behenyl ether 1
Dipropylene glycol 10
PEG-60 hydrogenated castor oil 0.2
Carboxyvinyl polymer * 1 0.2
Xanthan gum * 2 0.2
Sodium hyaluronate 0.01
10% potassium hydroxide 1
L-carnitine (manufactured by Kongo Chemical) 0.5
Rhododendrol (manufactured by Takasago International Corporation) 2.0
Isopropylmethylphenol (Osaka Kasei Co., Ltd .: Biosol) 0.1
Fire thorn extract (manufactured by Suntory: fire thorn) 0.1
Honeysuckle extract (manufactured by Maruzen Pharmaceutical Co., Ltd .: goldfish extract-J) 0.1
Dutch mustard extract (manufactured by Silab: WaterCress-KB) 0.1
Ghetto extract (manufactured by Maruzen Pharmaceutical Co., Ltd .: Moon peach leaf extract BG) 0.1
Oubak extract (manufactured by Maruzen Pharmaceutical Co., Ltd .: Oubak extract J) 0.1
Kyonin extract (Maruzen Pharmaceutical Co., Ltd .: Kyonin extract LA)
Edetate 0.03
Phenoxyethanol 0.35
Residual amount of water

Formulation Example 2 (Cosmetic liquid)
Ingredient Mass%
Polyoxyethylene (2) behenyl ether 1
1,3 Butylene glycol 10
PEG-60 hydrogenated castor oil 0.5
Carboxyvinyl polymer * 1 0.4
Xanthan gum * 2 0.2
Sodium hyaluronate 0.01
10% potassium hydroxide 2
γ-amino-β-hydroxybutyric acid (Kaken Pharmaceutical Co., Ltd .: Visamine) 0.5
Rhododendrol (manufactured by Takasago International Corporation) 2.0
N-methyl-L-serine (manufactured by Takasago International Corporation) 0.5
Soybean extract (manufactured by Sansho Pharmaceutical Co., Ltd .: fermented soymilk) 0.1
Honeysuckle extract (manufactured by Maruzen Pharmaceutical Co., Ltd .: goldfish extract-J) 0.1
Dutch mustard extract (manufactured by Silab: WaterCress-KB) 0.1
Ghetto extract (manufactured by Maruzen Pharmaceutical Co., Ltd .: Moon peach leaf extract BG) 0.1
Seaweed extract (Maruzen Pharmaceutical Co., Ltd .: Seaweed Extract M) 0.1
Edetate 0.03
Phenoxyethanol 0.35
Residual amount of water

Formulation Example 3 (Emulsion)
Ingredient Mass%
Polyoxyethylene (2) behenyl ether 1
1,3 Butylene glycol 10
PEG-60 hydrogenated castor oil 1.0
Squalane 5.0
Dimerlinoleic acid (phytosterol / isostearyl / cetyl / stearyl / behenyl) (Nippon Seika Co., Ltd .: Plandool-H) 2.0
Macadamia nut oil fatty acid phytosteryl (manufactured by Nippon Seika Co., Ltd .: YOFCO MAS)
1.5
Carboxyvinyl polymer * 1 0.4
Xanthan gum * 2 0.2
Sodium hyaluronate 0.01
10% potassium hydroxide 2
γ-amino-β-hydroxybutyric acid (Kaken Pharmaceutical Co., Ltd .: Visamine) 0.5
Rhododendrol (manufactured by Takasago International Corporation) 2.0
Niacinamide (Lonza Japan) 0.5
Soybean extract (manufactured by Sansho Pharmaceutical Co., Ltd .: fermented soymilk) 0.1
Honeysuckle extract (manufactured by Maruzen Pharmaceutical Co., Ltd .: goldfish extract-J) 0.1
Dutch mustard extract (manufactured by Silab: WaterCress-KB) 0.1
Ghetto extract (manufactured by Maruzen Pharmaceutical Co., Ltd .: Moon peach leaf extract BG) 0.1
Seaweed extract (Maruzen Pharmaceutical Co., Ltd .: Seaweed Extract M) 0.1
Yeast extract (Penta Farm, Dismutin BTJ) 0.1
Edetate 0.02
Phenoxyethanol 0.4
Residual amount of water

Claims (5)

The following components (A) to (C):
(A) a polyoxyethylene alkyl or alkenyl ether in which the alkyl group or alkenyl group has 20 to 24 carbon atoms and the average added mole number of ethylene oxide is 1.5 to 4,
An external preparation for skin containing (B) a water-soluble polymer and (C) a plant extract . (C) The plant extract is an extract from a plant belonging to the family Brassicaceae, Gramineae, Hypericumaceae, Romaceae, Gingeraceae, Honeysuckle, Rosaceae, Leguminosae, Citrus, Magnolia, Uchinosidae and Seaweed The skin external preparation according to claim 1 , which is one or more selected from the group consisting of: The skin external preparation according to claim 1 or 2 , wherein the polyoxyethylene alkyl or alkenyl ether (A) is a polyoxyethylene alkyl or alkenyl ether having an average addition mole number of ethylene oxide of 1.5 to 3. The external preparation for skin according to any one of claims 1 to 3 , wherein the polyoxyethylene alkyl or alkenyl ether (A) is contained in an amount of 0.5 to 20% by mass based on the total amount of the composition. The water-soluble polymer (B) is selected from the group consisting of carboxyvinyl polymer, acrylic acid / alkyl methacrylate copolymer, xanthan gum, hydroxypropyl methylcellulose, polyacrylamide, and (Na acrylate / acryloyl dimethyl taurine Na) copolymer. The skin external preparation according to any one of claims 1 to 4 , which is one kind or two or more kinds.