JP5719554B2 - Patch - Google Patents

Description

  The present invention relates to a patch.

Conventionally, patches have been widely used to improve stiff shoulders, low back pain, and foot edema due to fatigue. The patch is used to relieve and treat symptoms such as stiff shoulders by blending a paste (adhesive) with an anti-inflammatory analgesic or a blood flow promoter and allowing these drugs to be transdermally absorbed.
Such a patch is required to improve symptoms. For example, an external patch containing a negative ion generator such as tourmaline or rare earth ore in an adhesive layer has been proposed (for example, Patent Document 1). Such an external patch is said to promote blood circulation by negative ions generated from negative ion generators. Such a patch is not satisfactory in terms of immediate effect, for example, it takes time until the effect can be realized after being applied to the affected area.

  In response to such problems, there has been proposed a patch that is immediately effective by providing protrusions on the application surface and applying physical stimulation. As a patch having protrusions on the sticking surface, for example, an analgesic / anti-inflammatory patch using a support provided with ceramic protrusions on a cloth has been proposed (for example, Patent Document 2). In addition, a patch using a nonwoven fabric having a resin protrusion has been proposed (for example, Patent Document 3). Or the patch which applied the hydrogel containing polyacrylic acid to the surface in which the protrusion of the support body was provided is proposed (for example, patent document 4). In addition, for example, a patch in which a protrusion is formed on a pasting surface by foaming a resin has been proposed (for example, Patent Document 5). The patch of Patent Document 5 promotes blood flow by a protrusion having moderate hardness and elasticity.

JP 2003-171265 A Japanese Utility Model Publication No. 3-38325 JP-A-8-260330 JP 2004-298474 A JP 2005-185559 A

However, the symptom-improving effect of the patch described above is not always satisfactory. In particular, patches are required to have immediate effects of improving symptoms and further improving effects of symptoms.
Then, this invention aims at the patch which can aim at the further improvement of the improvement effect of a symptom while being able to actually realize the improvement effect of a symptom in a short time.

  As a result of intensive studies, the present inventors have formulated a germanium or black silica in the protrusions of the support, thereby improving the acupuncture stimulating effect of the protrusions and promoting blood flow such as l-menthol. The inventors have found that the effect of the agent is synergistically improved, and have reached the present invention.

  That is, the patch of the present invention has a sheet-like support provided with a plurality of protrusions on one side, and an adhesive layer provided on the one side and containing a blood flow promoter. The protrusions contain germanium and / or black silica. The protrusion is preferably formed by foaming a resin composition containing germanium and / or black silica, a resin and a foaming agent.

  According to the present invention, the symptom improvement effect can be realized in a short time, and the symptom improvement effect can be further improved.

It is sectional drawing which shows an example of the patch of this invention. It is a top view which shows the support body of the patch of FIG. It is sectional drawing explaining the structure of the projection part in the support body of FIG. It is a schematic diagram of the manufacturing apparatus of a support body explaining the manufacturing method of the patch of this invention.

  An example of the patch of the present invention will be described with reference to FIGS. FIG. 1 is a cross-sectional view showing a patch 8 of the present invention. FIG. 2 is a plan view of the support 10 constituting the patch 8 of FIG. FIG. 3 is a cross-sectional view illustrating the structure of the protrusion 20 in the support 10 of FIG.

  As shown in FIG. 1, the patch 8 includes a sheet-like support 10 and an adhesive layer 30 provided on one surface of the support 10. As shown in FIGS. 2 and 3, the support 10 includes a protrusion forming portion 16 in which a plurality of protrusions 20 are provided in a matrix on one surface of a sheet-like base material 12, and a periphery of the protrusion forming portion 16. The flat part 14 in which the projection part 20 is not provided is formed. The protruding portion 20 includes a base portion 22 soaked into the base material 12 and a protruding portion 24 exposed on the surface of the base material 12. The protruding portion 24 is formed in a spherical shape with a circular shape in plan view.

The base material 12 can be made of a material conventionally used as a support for a patch. For example, paper, a fiber sheet, a porous body, a foam, a plastic film, a laminate of a plastic film and a fiber sheet or paper, an anchor coat processed product of a plastic film, and the like can be given.
As the above-mentioned fiber sheet, woven fabrics such as thick weave, yarn weave, gauze, corten, and flannel, knitted fabrics by production methods such as flat knitting, rubber knitting, tuck knitting, double stitch knitting, spun lace, spunbond, Nonwoven fabric produced by a production method such as thermal bond, chemical bond, needle punch, or the like can be used. Examples of the material of the fiber sheet include, for example, polyester resins such as rayon, polyamide, polyethylene, polyethylene terephthalate, polyolefin resins such as polypropylene, polyester ether, polyurethane resins, acrylic resins, polyvinyl alcohol, polystyrene resins, Examples include cotton and hemp. Of these, polyester resins, polyethylene resins, and polypropylene resins are preferable. These resins may be used alone or as a blended fiber of two or more.

  The material of the porous body, foam, and film (sheet) includes polyolefin resins such as polyethylene and polypropylene; acrylic resins such as polymethyl methacrylate; polyester resins such as polyethylene terephthalate, polybutylene terephthalate, and polyethylene naphthalate; , Polyvinyl alcohol, ethylene / vinyl alcohol copolymer, polyvinyl chloride, polyvinylidene chloride, polystyrene, polyurethane resin, polyacrylonitrile, fluorine resin, styrene / isoprene / styrene block copolymer, styrene / butadiene / styrene block copolymer Polymer, styrene / ethylene / propylene / styrene block copolymer, styrene / butadiene rubber, ethylene / vinyl acetate copolymer, polyamide, polysulfone, poly Ester-based, styrene-based, polyester-based or thermoplastic elastomers or the like of the copolymer rubber. The polymerization degree is not particularly limited, and those having a polymerization degree that is usually used as a support for a patch can be used.

  The thickness of the base material 12 is not specifically limited, For example, 10-200 micrometers is preferable and 15-100 micrometers is more preferable. When the base material 12 is too thin, the base material 12 may be cut or difficult to peel off when the patch 8 is peeled from the skin. If the substrate 12 is too thick, it may be difficult to stick to the curved surface, and the pressure-sensitive adhesive layer 30 side may not be in close contact with the affected part. Further, the surface of the substrate 12 on the side where the pressure-sensitive adhesive layer 30 is formed and the surface opposite to the side where the pressure-sensitive adhesive layer 30 is formed may be subjected to surface modification treatment such as corona treatment. , Embossing, printing, etc. may be applied.

  The protrusion 20 is a resin composition containing germanium and / or black silica (hereinafter referred to as (A) component), a resin (hereinafter referred to as (B) component) and a foaming agent (hereinafter referred to as (C) component). It is formed by foaming.

As germanium which is the component (A), for example, any of germanium oxide, organic germanium, and inorganic germanium can be used, and it is preferable to use a germanium powder obtained by powdering these. By using germanium powder, the symptom improvement effect can be improved.
The blending amount of the component (A) in the resin composition can be determined in consideration of the type of the component (A) and the like. For example, 0.0005 to 20% by mass is preferable, and 0.0005 to 10% by mass is more preferable. 1-10 mass% is further more preferable. If the amount is less than 0.0005% by mass, the effect of improving the symptoms such as stiff shoulders and edema is difficult to obtain, and if the amount exceeds 20% by mass, the effect of improving the symptoms cannot be further improved and the cost is increased. Furthermore, if it is 10 mass% or less, balance with another component will be taken and formation of the projection part 20 will be easy.

The component (B) can be determined in consideration of the hardness and the like required for the projecting portion 20, for example, a polyacrylate resin, ethylene / vinyl acetate resin, polyethylene resin, polyvinyl chloride ethylene / vinyl chloride Resin, acrylic / styrene resin, polystyrene resin, polyurethane resin, polyester resin, styrene butadiene rubber (SBR) resin, acrylonitrile butadiene rubber (NBR) resin, methacrylate butadiene synthetic rubber (MBR) resin , Polychloroprene resin, polyisoprene resin and the like. Among these, in view of flexibility, light discoloration resistance, safety, heat resistance, price, and the like, polyacrylate resins and acrylic / styrene resins are preferable.
The compounding quantity of (B) component in a resin composition can be determined in consideration of the hardness etc. which are desired for the projection part 20, for example, 30-60 mass% is preferable. If it is in the said range, it can be set as the projection part 20 of the desired property.

The component (C) can be determined in consideration of the type of the component (B) and the like. For example, a microcapsule foaming agent in which the gas contained therein is expanded by heating to increase the volume can be used. The microcapsule foaming agent is preferably one that foams at 100 to 120 ° C., although it depends on the type of gas encapsulated. Examples of the component (C) include thermally expandable microcapsule-containing ethylene / vinyl acetate, thermally expandable microcapsule-containing propylene, and thermally expandable microcapsule-containing polyethylene.
The blending amount of the component (C) in the resin composition can be determined in consideration of the type of the component (C), the hardness required for the protruding portion 20, and the like, and is preferably 0.1 to 10% by mass, for example.

  The mass ratio of the component (C) and the component (A) in the resin composition is preferably (C) / (A) = 0.005 to 20000, more preferably 0.05 to 4000. If it is less than the lower limit, the balance of the resin composition may be poor, and the protrusion 20 may be too hard and the skin may be too irritating. When the upper limit is exceeded, the balance of the resin composition is poor, physical stimulation becomes insufficient, and it becomes difficult to obtain an effect of improving symptoms such as stiff shoulders and edema due to acupuncture stimulation.

  The resin composition may contain an inorganic filler (hereinafter referred to as “component (D)”), a thickener, and the like as necessary.

Examples of the component (D) include clay minerals such as smectite and kaolin, oxides such as zinc oxide and titanium oxide, hydroxides such as aluminum hydroxide and calcium hydroxide, and silicates such as zeolite. These can be used individually by 1 type or in combination of 2 or more types as appropriate. Of these, kaolin, titanium oxide, and aluminum hydroxide are preferable, and kaolin is more preferable.
The amount of component (D) in the resin composition can be determined in consideration of the amount of component (A), the types of component (B) and component (C), and the like. For example, the blending amount of the component (D) in the resin composition is preferably 50 to 70 mass%, more preferably 50 to 60 mass%, as the total amount of the component (A) and the component (D). If it is less than 50% by mass, the protrusion 20 becomes too soft, and there is a possibility that the effect of symptom improvement by acupuncture stimulation cannot be exhibited. When it exceeds 70 mass%, there exists a possibility that damage may arise in the projection part 20 or formation of the projection part 20 may become difficult.

The thickener can be determined in consideration of the viscosity, workability and the like required for the resin composition, and examples thereof include a fiber derivative and an alginate.
As for the compounding quantity of the thickener in a resin composition, 0.05-3 mass% is preferable.

  The area ratio between the flat part 14 and the protrusion forming part 16 can be determined in consideration of the material of the pressure-sensitive adhesive layer 30, the size of the protruding part 20, and the like. For example, it is preferable that the area ratio represented by the protrusion forming portion 16: the flat portion 14 is 1: 0.5 to 1: 3. If it is in the said range, the favorable adhesiveness to the affected part of the patch 8 will be acquired, and the patch 8 can be stuck over a long time. In addition, the feeling of use (cool feeling, warm feeling, etc.) due to the drug contained in the pressure-sensitive adhesive layer 30 can be maintained.

2-25 mm is preferable and, as for the space | interval P (FIG. 2) of the arbitrary projection part 20 and the projection part 20 adjacent to this arbitrary projection part 20, 4-15 mm is more preferable. If it is the said range, while being able to obtain moderate acupoint stimulation, there is little irritation | stimulation to skin.
Although the arrangement density of the protrusions 20 is not particularly limited, for example, 0.5 to 10/4 cm ² is preferable, and 1 to 5/4 cm ² is more preferable. If the arrangement density of the protrusions 20 is too low, the blood flow promoting effect is difficult to be sustained, and the acupuncture stimulation by the protrusions 20 is small, and satisfaction cannot be obtained. If the arrangement density of the protrusions 20 is too high, the skin irritation by the protrusions 20 may be too strong.

  The size of the protrusion 20 can be determined in consideration of the hardness of the protrusion 20 and the like. For example, the maximum diameter of the protrusion 20 is preferably 2 to 10 mm, and more preferably 2.5 to 7 mm.

  The height H (FIG. 3) of the protruding portion 24 of the protruding portion 20 can be determined in consideration of the hardness of the protruding portion 20, the arrangement density, and the like. For example, the height H is preferably 2 to 7 mm, more preferably 2.5 to 5 mm, and still more preferably 3 to 5 mm. Within the above range, moderate acupuncture stimulation can be obtained and skin irritation is low.

The hardness of the protrusion 20 can be determined in consideration of the size of the protrusion 20 and the like. As for the hardness of the projection part 20, 40 to 100% of a retention rate is preferable, for example, and 60 to 80% is more preferable. This is because, within the above range, moderate acupuncture stimulation can be obtained, the skin irritation does not become too strong, and a favorable symptom improvement effect is obtained.
In addition, a retention rate is the height H2 (mm) at the time of pressing the projection part 20 with 0.9 kg using the fruit hardness meter (KM-1, manufactured by Fujiwara Manufacturing Co., Ltd.), and the height H1 before pressing ( mm) and is calculated by the following formula. In addition, the retention rate of the protrusion part 20 can be adjusted with the kind and its combination of (A)-(C) component in a resin composition, the compounding quantity of each component, and the foaming ratio mentioned later.

  Retention rate (%) = H2 ÷ H1 × 100 (1)

  The protrusion 20 preferably has an expansion ratio of 1.1 to 3.0. If it is less than 1.1, the skin portion irritation of the protrusion 20 becomes too strong, and pain may be felt at the time of application. If it exceeds 3.0, the strength of the protrusion 20 may be reduced, or physical irritation to the affected area may be insufficient. The expansion ratio is the ratio of the volume of the protrusion 20 that is a foam to the volume of the protrusion (protrusion formed without foaming) when formed without using the component (C).

  The pressure-sensitive adhesive layer 30 includes a pressure-sensitive adhesive containing a blood flow promoting agent. As long as the pressure-sensitive adhesive contains a blood flow promoter, either a water-based pressure-sensitive adhesive or a non-water-based pressure-sensitive adhesive may be used, and among them, a water-based pressure-sensitive adhesive is preferably used. The water-containing pressure-sensitive adhesive has a high cooling effect on the affected area, and has good adhesion to the affected area, so that it is easy to feel physical irritation due to the protrusion 20. Furthermore, the water-containing pressure-sensitive adhesive is less irritating to the skin when the patch 8 is peeled from the affected area.

The blood flow promoter contained in the adhesive is a cooling agent such as l-menthol and camphor, capsaicin, capsaicin, capsaicinoid, dihydrocapsaicin, capsaicin analogs such as capsanthin, red pepper extract, red pepper tincture, red pepper powder and the like Hot sensation agents such as a pepper-derived warming sensation agent, benzyl nicotinate, β-butoxyethyl nicotinate, N-acyl vanilamide, nonyl acid vanillamide, nonyl acid vanillyl amide and the like can be mentioned. Among these blood flow promoters, a cooling agent is more preferable, and l-menthol is more preferable.
By using such a blood flow promoting agent, it can be expected that the symptom improving effect by physical stimulation of the protrusion 20 and the blood flow promoting effect by the drug are synergistically improved.

The content of the blood flow promoting agent in the adhesive can be determined according to the type of the drug. For example, when using a cooling sensation agent, 0.01-10 mass% is preferable and, as for content of the cooling sensation agent in an adhesive, 0.1-8 mass% is more preferable. If it is less than the lower limit, effects such as blood flow promotion, refreshing feeling or cooling feeling may be insufficient. If the upper limit is exceeded, the refreshing feeling is too strong or the skin irritation is too strong. There is a risk.
For example, when using a warming agent, 0.001-5 mass% is preferable and, as for content of the warming agent in an adhesive, 0.005-2 mass% is more preferable. If it is less than the lower limit, effects such as blood flow promotion and warming may be insufficient, and if the upper limit is exceeded, there is a risk that skin irritation may be too strong.

The water-containing pressure-sensitive adhesive contains a water-soluble polymer substance, and is preferably a polymer gel having a network structure with a water-soluble polymer substance.
Although the moisture content in a water-containing adhesive is not specifically limited, For example, 43-85 mass% is preferable. Moreover, as for pH of a water-containing adhesive, 3.0-6.0 are preferable.

  The water-soluble polymer substance is not particularly limited. For example, the water-soluble polymer substance having a carboxyl group in the molecule and a salt or partially neutralized product thereof, gelatin, carboxymethylcellulose and sodium salt, potassium salt, sodium alginate, Examples include maleic anhydride copolymer, sodium carboxymethyl starch, natural rubber having a carboxyl group, celluloses such as hydroxypropyl cellulose, polyvinyl alcohol, polyvinyl pyrrolidone, pectin, xanthan gum, tragacanth and the like. Among these, from the viewpoint of shape retention, a water-soluble polymer substance having a carboxyl group in the molecule, a salt thereof, or a partially neutralized product thereof is preferable. Examples of such a water-soluble polymer substance include polyacrylic acid, carboxymethyl cellulose, alginic acid, carboxyvinyl monomer and salts thereof, or partially neutralized products thereof. Among them, polyacrylic acid, polyacrylic acid salt or partially neutralized product thereof (hereinafter generally referred to as polyacrylic acid (salt)) is preferable, and polyacrylic acid (salt), carboxymethylcellulose, alginic acid, carboxyvinyl polymer, and these It is preferable to blend one or more selected from salts.

The polyacrylic acid (salt) is not particularly limited, but the weight average molecular weight is preferably 10,000 to 10,000,000, and from the viewpoint of improving the feeling of use, 10,000 to less than 500,000 polyacrylic acid (salt), 500,000 to 2,000,000. It is preferable to use 2 or more types of polyacrylic acid (salt) of less than 2 million to 7 million in combination.
Examples of polyacrylates include monovalent metal salts such as sodium polyacrylate and potassium polyacrylate, amine salts such as polyethanol monoethanolamine, polyethanol diethanolamine and polyethanol triethanolamine, and polyacrylic acid. An ammonium salt etc. are mentioned. When combining polyacrylic acid and polyacrylate, the mass ratio of polyacrylic acid: polyacrylate is preferably 1:10 to 10: 1, and more preferably 1: 9 to 9: 1.

Moreover, you may use what made the polyacrylic acid salt the said ratio by partially neutralizing polyacrylic acid. When the partially neutralized product of polyacrylic acid is used, the degree of neutralization is preferably less than 10 to 50 mol%.
As the polyacrylic acid (salt), a commercially available product can be used. As polyacrylic acid, Jurimer AC-10H (manufactured by Nippon Pure Chemical Co., Ltd., 20 mass% aqueous solution, weight average molecular weight: 100,000), and sodium polyacrylate Aronbis S (manufactured by Nippon Pure Chemical Co., Ltd., weight average molecular weight: 4 million to 5 million), Aronbis AH-106X (manufactured by Nippon Pure Chemical Industries, Ltd., weight average molecular weight: 4 million to 500 million) as a partially neutralized polyacrylic acid And Aronbis AH-105X (manufactured by Nippon Pure Chemical Co., Ltd., weight average molecular weight: 4 million to 5 million, neutralization degree 50 mol%).

  0.1-20 mass% is preferable, as for polyacrylic acid (salt) in a water-containing adhesive, 0.5-15 mass% is more preferable, and 5-10 mass% is further more preferable. If the blending amount is less than 0.1% by mass, the adhesive strength may be insufficient. If the blending amount exceeds 20% by mass, the viscosity becomes high, which may cause problems in workability during production.

The water-containing pressure-sensitive adhesive can be blended with a crosslinking agent for crosslinking the water-soluble polymer compound. The crosslinking agent is not particularly limited, for example, alum such as potassium alum, ammonium alum, iron alum, etc., aluminum hydroxide, aluminum sulfate, aluminum ammonium sulfate, potassium aluminum sulfate, aluminum chloride, dihydroxyaluminum aminoacetate, aluminum acetate, Aluminum compounds such as aluminum oxide, synthetic aluminum silicate, and aluminum metasilicate, calcium compounds such as calcium hydroxide, calcium carbonate, calcium sulfate, calcium nitrate, calcium chloride, calcium acetate, calcium oxide, and calcium phosphate, magnesium hydroxide, magnesium carbonate , Magnesium sulfate, magnesium acetate, magnesium silicate, magnesium oxide and other magnesium compounds, aluminum hydroxide・ Multivalent such as magnesium, magnesium aluminate metasilicate, magnesium aluminate silicate, synthetic hydrotalcite, zinc compound, cadmium compound, titanium compound, tin compound, iron compound, chromium compound, manganese compound, cobalt compound, nickel compound Metal compounds are preferred. Of these, inorganic polyvalent metal compounds such as aluminum compounds, magnesium compounds, and calcium compounds are preferable from the viewpoint of influence on the skin. These crosslinking agents can be used alone or in combination of two or more.
The amount of the crosslinking agent in the water-containing pressure-sensitive adhesive can be determined in consideration of the type of the water-soluble polymer compound, and is preferably 0.001 to 10% by mass, and preferably 0.01 to 5% by mass. If it is less than the said lower limit, the cohesion force of a water-containing adhesive may fall, and if it exceeds the said upper limit, adhesive force may fall.

The water-containing pressure-sensitive adhesive can contain a water-soluble polymer compound, a crosslinking agent, a crosslinking regulator, a polyhydric alcohol, an oil component, a surfactant, and the like.
A crosslinking regulator adjusts the crosslinking rate of a water-soluble polymer compound, for example, chelating agents, such as sodium edetate, a citric acid, tartaric acid, are mentioned. As for the compounding quantity of the crosslinking regulator in a water-containing adhesive, 0.01-2.0 mass% is preferable, for example.

The polyhydric alcohol is not particularly limited. For example, 1,3-butanediol, ethylene glycol, propylene glycol, butylene glycol, isoprene glycol, glycerin, diglycerin, triglycerin, polyglycerin, diethylene glycol, dipropylene glycol, diethylene glycol mono Examples include alkyl ether, polyethylene glycol, polypropylene glycol, polyethylene glycol / polypropylene glycols, sorbitol and the like. Among these, diethylene glycol monoalkyl ether, isoprene glycol, polyethylene glycol, polyethylene glycol / polypropylene glycol, polypropylene glycol, and glycerin are preferable. By blending the polyhydric alcohol, the shape retention of the pressure-sensitive adhesive is improved. In addition, the dispersibility of a compounding component can be improved at the time of manufacture of an adhesive.
The blending amount of the polyhydric alcohol in the water-containing pressure-sensitive adhesive is, for example, preferably 0.1 to 30% by mass, more preferably 4 to 25% by mass, and particularly preferably 5 to 20% by mass.

Examples of oil components include castor oil, olive oil, sunflower oil, macadamia nut oil, jojoba oil, lanolin, hydrogenated oil, lecithin, plastin base, liquid paraffin, oleic acid, stearic acid, myristic acid, palmitic acid, beeswax, paraffin wax, Examples thereof include microcrystalline wax, diisopropyl adipate, isopropyl myristate, isopropyl sebastate, isopropyl palmitate, squalane, squalene, cetanol, stearyl alcohol, oleyl alcohol, hexadecyl alcohol, and silicone oil. Among them, castor oil, olive oil, sunflower oil, macadamia nut oil, and jojoba oil are highly effective in suppressing bubbles, and castor oil, macadamia nut oil, and jojoba oil are particularly preferable. By mix | blending such an oil-based component, the adhesive layer 30 without a bubble is obtained. In particular, in the present invention, since the protrusion 10 is provided on the support 10, when the pressure-sensitive adhesive layer 30 is provided, air is easily engulfed by the protrusion 20 to form bubbles. For this reason, the adhesive layer 30 without a bubble can be easily provided by mix | blending an oil-based component.
The blending amount of the oil component in the water-containing pressure-sensitive adhesive is preferably 0.1 to 5% by mass, and more preferably 0.5 to 3% by mass.

  Examples of the surfactant include polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene glycol fatty acid ester, polyoxyethylene glycol ether, polyoxyethylene alkylphenyl ether, polyoxyethylene alkylphenyl ether, Examples thereof include oxyethylene polyoxypropylene alkyl ether, polyoxyethylene phytosterol, sorbitan fatty acid ester, and glycerin fatty acid ester.

The non-aqueous adhesive is an adhesive made of an acrylic polymer compound. The acrylic polymer compound is not particularly limited. For example, an acrylic acid / octyl acrylate copolymer, an acrylic ester / acrylic acid ester, which is listed as an adhesive in the Pharmaceutical Additives Encyclopedia 2007 (edited by the Japan Pharmaceutical Additives Association). Vinyl acetate copolymer, 2-ethylhexyl acrylate / vinyl pyrrolidone copolymer, 2-ethylhexyl acrylate / 2-ethylhexyl methacrylate / dodecyl methacrylate copolymer, methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion, methacryl Acid / n-butyl acrylate copolymer, pressure sensitive adhesive such as alkanolamine liquid, DURO-TAK acrylic pressure sensitive adhesive series (trade name, manufactured by National Starch and Chemical Co.), Eudragit series (trade name, manufactured by Higuchi Shokai Co., Ltd.) Kollicho (Trade name, manufactured by BASF Japan Co., Ltd.), Rodamu (trade name, manufactured by Rohm and Haas Japan Co., Ltd.), Nikasol (trade name, manufactured by Nippon Carbide Industries Co., Ltd.) and the like can be suitably used.
Acrylic polymer compounds can be used singly or in appropriate combination of two or more.
The proportion of the acrylic polymer compound in the non-aqueous pressure-sensitive adhesive is preferably 30 to 95% by mass, more preferably 50 to 90% by mass, and particularly preferably 55 to 90% by mass.

A polymerization initiator, a reducing agent, a surfactant, a crosslinking agent, a plasticizer, a crosslinking regulator, and the like can be blended with the non-aqueous pressure-sensitive adhesive as necessary.
Examples of the polymerization initiator include persulfates such as ammonium persulfate and sodium persulfate; aqueous radical polymerization initiators such as hydrogen peroxide, lauroyl peroxide, and t-butyl hydroperoxide, or a mixture thereof.
0.01-5 mass% is preferable with respect to 100 mass% of monomers used for a synthesis | combination, and, as for the compounding quantity of a polymerization initiator, 0.1-2 mass% is more preferable.
A redox system can also be formed by combining a polymerization initiator with a reducing agent. Examples of the reducing agent include alkali metal salts such as sulfites, hydrogen sulfites, pyrosulfites, and formaldehyde sulfonates; and carboxylic acids such as ammonium salts, L-ascorbic acid, and tartaric acid.
The blending amount of the reducing agent is preferably 0.01 to 5% by mass and more preferably 0.1 to 2% by mass with respect to 100% by mass of the monomer used for synthesis.

The acrylic polymer compound is preferably produced by emulsion polymerization. As the surfactant used for the emulsion polymerization, an anionic surfactant, a cationic surfactant, a nonionic surfactant, an amphoteric surfactant, or a mixture thereof can be used.
Surfactant can be used individually by 1 type or in combination of 2 or more types as appropriate.
0.1-10 mass% is preferable with respect to 100 mass% of monomers used for a synthesis | combination, and, as for the compounding quantity of surfactant, 0.5-5 mass% is more preferable. If it is 0.1 mass% or more, an emulsion polymerization reaction will progress more stably and the production | generation of an aggregate will be suppressed. On the other hand, if it is 10 mass% or less, drying property and water resistance will improve.
In the emulsion polymerization, a chelating agent such as sodium ethylenediaminetetraacetate, a dispersant such as polycarboxylate, an inorganic salt such as phosphate and carbonate, a chain transfer agent such as a thiol compound and a halogen compound, if necessary. Can be done below.

Examples of the crosslinking agent blended with the non-aqueous pressure-sensitive adhesive include polyvalent metal compounds that are inorganic polyvalent metal compounds or organic polyvalent metal compounds, isocyanate compounds (preferably trifunctional isocyanate compounds), epoxy compounds, and the like. A polyvalent metal compound is preferred, and an inorganic polyvalent metal compound is more preferred. The inorganic polyvalent metal compound is the same as the crosslinking agent for the water-containing pressure-sensitive adhesive.
0.01-2 mass% is preferable, as for the compounding quantity of the crosslinking agent in a non-aqueous adhesive, 0.05-1 mass% is more preferable, and 0.1-1 mass% is further more preferable.

Examples of the plasticizer include dihydric alcohols (for example, ethylene glycol, propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, 1,3-hexylene glycol, etc.), trihydric alcohols (for example, glycerin, trimethylol). Propane, etc.), polyhydric alcohols such as tetrahydric alcohols (eg erythritol, pentaerythritol, diglycerin etc.), pentahydric alcohols (eg xylitol etc.), hexahydric alcohols (eg sorbitol, dipentaerythritol etc.); glucose Sugars such as mannose, sucrose, sorbitan, trehalose and alkylglycosides; polymers of polyhydric alcohols such as polyethylene glycol, polypropylene glycol and polyglycerin; fatty acid esters or derivatives thereof Higher alcohols or derivatives thereof having 8 to 20 carbon atoms such as octyldodecanol; olive oil, fats and oils such as castor oil, and the like. Among these, polyhydric alcohols, fatty acid esters, and fats and oils are preferable, and polyhydric alcohols and fatty acid esters are more preferable. In particular, when a drug is contained, a fatty acid ester is preferred because the transdermal absorbability of the drug is good. Examples of fatty acid esters include isopropyl myristate, diethyl sebacate, diisopropyl sebacate, diisopropyl adipate, ethyl oleate, isopropyl palmitate, octyl palmitate, oleyl oleate, isotridecyl myristate, ethyl laurate, and the like. . By blending such a plasticizer, the wettability to the skin is improved and the adhesiveness is increased, and at the same time, pain when the patch 8 is peeled is reduced.
These plasticizers can be used singly or in appropriate combination of two or more.
5-35 mass% is preferable, as for the compounding quantity of the plasticizer in a non-aqueous adhesive, 5-30 mass% is more preferable, and 5-20 mass% is further more preferable.

The crosslinking regulator is preferably, for example, a chelating agent that forms a chelate with the crosslinking agent. As the chelating agent, for example, citric acid, sodium edetate hydrate, tartaric acid, diethylenetriaminepentaacetic acid, or monovalent metal salts of these compounds are more preferable. Examples of the crosslinking regulator include polyisocyanate compounds, organic peroxides, organic metal salts, metal alcoholates, and the like.
0.01-5 mass% is preferable and, as for the compounding quantity of the crosslinking regulator in a non-aqueous adhesive, 0.1-2 mass% is more preferable.

The adhesive may further contain a drug other than the blood flow promoter, a fragrance, a pigment, a preservative, and the like.
Examples of drugs other than blood flow promoting agents include anti-inflammatory analgesics and the like.
Examples of anti-inflammatory analgesics include indomethacin, ketoprofen, flurbiprofen, glycol salicylate, glycyrrhetinic acid derivatives such as methyl salicylate, glycyrrhetinic acid, stearyl glycyrrhetinate, and glycyrrhizic acid (salt).
Content of the chemical | medical agent in an adhesive can be determined according to the kind of chemical | medical agent.

  As the fragrance, any of a natural fragrance, a synthetic fragrance, or a fragrance composition containing these can be used. Examples of natural fragrances include anise, angelica, benzoin, immortelle, chamomile, garlic, cardamom, galvanum, caraway, carrot seed, guayakwood, grapefruit, cypress, sandalwood, cedarwood, juniper, jasmine, star anise, sage, Geranium, celery, thyme, tarragon, turpentine, spruce, frankincense, violet, pine, parsley, birch, patchouli, rose, hyssop, fennel, black pepper, bodaiju flower, pill, orange, lemon, lemongrass, rosemary, Herbal essential oils or extracts such as laurel, shimotsukigi, peach, cornflower, eucalyptus, yuzu and lavender are preferably used.

  Conventionally, various dyes used in patches can be used, but it is preferable to use a pigment from the viewpoint of dyeability on the skin.

  Examples of the preservative include benzoic acid, sodium benzoate, benzalkonium chloride, paraben, cresol, oxyquinoline sulfate and the like.

  An example of a method for producing the patch 8 of the present invention will be described. First, components (A) to (C) are dispersed in a resin dispersion medium to prepare a resin composition slurry. This resin composition slurry is applied to one surface of the substrate 12 so as to form the pattern of FIG. Next, the base material 12 coated with the resin composition slurry is dried. During this time, the resin dispersion medium in the resin composition slurry evaporates and the foaming agent in the resin composition foams. In this way, the support body 10 in which the protrusion part 20 which is a foam is formed is obtained.

  A constituent component of the pressure-sensitive adhesive is dispersed or dissolved in a pressure-sensitive adhesive dispersion medium to prepare a pressure-sensitive adhesive coating solution. The patch 8 can be obtained by applying a pressure-sensitive adhesive coating liquid to the surface of the obtained support 10 on which the protrusions 20 are formed. In addition, when an adhesive coating liquid contains a non-aqueous adhesive, after apply | coating an adhesive coating liquid and drying further, the patch 8 can be obtained.

  The resin dispersion medium can be determined in consideration of the types of the components (A) to (C), and examples thereof include alcohols such as methanol and ethanol, and water.

  Although the viscosity of a resin composition is not specifically limited, For example, it is preferable to prepare in the range of 5000-30000 mPa * s. If it exists in the said range, since it will be easy to apply | coat to the base material 12 and a shape will be maintained after application | coating, it will become easy to obtain the projection part 20 of a desired shape.

  The resin composition in the resin composition slurry, that is, the solid content is preferably 40 to 70% by mass. This is because, if it is within the above range, drying is easy and the protrusion 20 having sufficient strength and height can be provided. In addition, it is possible to prevent scorching and discoloration during drying.

  The method for applying the resin composition slurry is not particularly limited, and conventionally known methods can be used. For example, the method of apply | coating a resin composition slurry to a predetermined pattern by discharge from a nozzle is mentioned.

  Further, for example, a method of transferring with the support manufacturing apparatus 100 of FIG. FIG. 4 is a schematic diagram showing the support manufacturing apparatus 100. In the figure, reference numeral 131 denotes a backup roll, 132 denotes a screen disposed opposite to the backup roll 131, 133 denotes a squeegee provided in the screen 132, and 134 denotes a squeegee. This is a squeegee support device.

The backup roll 131 is in contact with the screen 132, moves between the backup roll 131 and the screen 132 so that the base material 12 follows the backup roll 131, and the resin composition slurry 135 extruded from the holes 132 a to the base material 12. What is transferred in the form of a matrix is sent to a subsequent process.
The screen 132 has a plurality of holes 132a in a predetermined pattern, and the inside of the screen 132 is filled with the resin composition slurry 135 as described above. The screen 132 is fixed to a screen mounting device (not shown).
The squeegee 133 is fixed to the squeegee support device 134 so that the tip of the squeegee 133 overlaps the intersection of the screen 132 and the line connecting the backup roll 131 and the center of the screen 132.
An electric drive device 155 is provided upstream of the squeegee 133 in the traveling direction of the base material 12. A control device 150 is electrically connected to the electric drive device 155, and a sensor 140 is electrically connected to the control device 150.

  The squeegee support device 134 can adjust the contact angle of the squeegee 133 by rotating, and the amount of rotation can be managed by the gage 134a. The push amount can be adjusted by a handle 134b for moving the squeegee support device 134 back and forth, and the push amount can be managed by a gage 134c.

The sensor 140 is a device that detects a positional shift and / or meandering of the base material 12. Examples of the sensor 140 include an optical transmission sensor, a reflective line sensor, a sound wave sensor, and a contact sensor. An example of the signal controller (control device) 150 is an EPC (edge position controller).
The control device 150 is a device that detects the position of one end of the base material 12 and instructs correction of the positional deviation and / or meandering.
The electric drive device 155 is a device that corrects the base material 12 to an arbitrary position in accordance with an instruction from the control device 150. Examples of the electric drive device 155 include a device that controls the position by moving the unwinding raw material (base material 12) to the left and right with an electric cylinder. Further, for example, there is a roll guider that corrects the position by changing the angle of the roll with an arbitrary fulcrum while the two rolls are parallel. These devices can be used in any combination.

  The base member 12 advances between the backup roll 131 and the screen 132 so that the base member 12 is wound around the backup roll 131 while the deviation and meandering are corrected by the electric drive device 155. During this time, the resin composition slurry 135 is rubbed against the inner surface of the screen 132 by the squeegee 133, pushed out from the holes 132a, and transferred to the substrate 12. At this point, since the resin composition slurry 135 is in a slurry form, a part of the slurry applied to the base material 12 soaks into the base material 12 and the remaining part remains on the base material 12 in a protruding shape. And by making it dry and foam, the protrusion part 24 (refer FIG. 3) is formed on the base material 12, and the base 22 (refer FIG. 3) is formed in the base material 12. FIG.

  Examples of the drying of the resin composition slurry 135 applied on the substrate 12 include a method of blowing hot air onto the substrate 12 and a method of heating in a thermostatic bath. From the viewpoint of productivity, drying with hot air is preferable. The temperature of the hot air can be determined in consideration of the type of the dispersion medium and the foaming agent in the resin composition slurry 135, for example, preferably 120 to 210 ° C, more preferably 120 to 180 ° C, and further 130 to 170 ° C. preferable.

  Conventionally, a known method can be used as a method of applying the pressure-sensitive adhesive coating solution to the support 10, and examples thereof include a bar coater, a gravure coater, a knife coater, and a roll sand coater. In order to uniformly apply the pressure-sensitive adhesive coating solution containing the water-containing pressure-sensitive adhesive while preventing the protrusion 20 from cracking, it is preferable to use the coating method disclosed in JP-A-2006-14857. .

  As described above, since the patch 8 is provided with the protrusion 20 on one surface of the support 10, the protrusion 20 presses the acupuncture points near the affected area to give a physical stimulus. For this reason, the symptom improvement effect is exhibited in a short time. In addition, since the protrusion 20 becomes a foam having an appropriate hardness and elasticity by containing the component (A), it prevents the skin irritation from becoming too strong and prolongs the comfortable physical irritation. Can be demonstrated over time. Furthermore, by optimizing the hardness of the protrusion 20, the blood flow promoting effect is improved in combination with a blood flow promoting agent such as l-menthol or nonyl acid vanillylamide blended in the pressure-sensitive adhesive layer.

The present invention is not limited to the embodiment described above.
In the above-described embodiment, the shape of the protrusion 20 is a spherical shape in plan view. However, the shape of the protruding portion 20 can be determined in consideration of the hardness of the protruding portion 20 and the like, for example, a circular cone shape in a plan view, a truncated cone shape, a cylindrical shape, a polygonal pyramid shape in a plan view polygonal shape, and a prismatic shape. Or any other shape.

In the above-described embodiment, the protrusions 20 are arranged in a matrix. However, for example, the protrusions 20 may be arranged in a strip shape such as vertically arranged, corrugated, spiral, or arranged in a grid. Also good.
In the case where the protrusions 20 are arranged in a strip shape, the maximum width is preferably 2 to 6 mm. The maximum diameter is the diameter of the protrusion 20 when the shape of the protrusion 20 is circular in plan view, and the diameter of a circle circumscribing the polygon when the shape is a polygon in plan view. .

  In the above-described embodiment, the protrusion 20 is covered with the pressure-sensitive adhesive layer 30, but the protrusion 20 may be exposed from the pressure-sensitive adhesive layer 30. When the protrusions 20 are exposed from the pressure-sensitive adhesive layer 30, the patch 8 may have a reduced contact area between the pressure-sensitive adhesive layer 30 and the skin if the arrangement density of the protrusions 20 is too high.

  In the above-described embodiment, the protrusion 20 is a foam obtained by foaming the resin composition containing the components (A) to (C). However, the protrusion 20 is not limited to a foam, and may be, for example, a molded product of a resin composition containing the component (A) and the component (B). However, in order to moderate the physical irritation to the skin of the protrusion 20 and to make the acupuncture moderate, the protrusion 20 is preferably a foam.

EXAMPLES Hereinafter, the present invention will be described more specifically with reference to examples. However, the present invention is not limited to the following examples.
(Raw materials used)
[(A) component: germanium and / or black silica]
Germanium powder: Germanium powder, bug, manufactured by the joint association Lastest Black silica: Chemical product, manufactured by Wako Pure Chemical Industries, Ltd.

[(B) component: resin]
Resin: Acrylic resin, acrylic resin emulsion, Boncoat, manufactured by DIC Corporation

[(C) component: foaming agent]
Foaming agent: Matsumoto Microsphere F, manufactured by Matsumoto Yushi Seiyaku Co., Ltd.

[(D) component: inorganic filler]
Inorganic filler: Kaolin, Katsuyama Kaolin, manufactured by Katsuyama Mining Co., Ltd.

[Blood flow promoter]
Cooling sensation agent: l-menthol, manufactured by Takasago Fragrance Industry Co., Ltd.

[Adhesive]
<Water-containing adhesive coating solution>
Sodium edetate (Kyrest 2BST, Kyrest) with 0.5% by mass of polyoxyethylene hydrogenated castor oil (HCO-60, manufactured by Nikko Chemicals Co., Ltd.) heated and dissolved in the compounded amount shown in the table and dissolved in purified water (Made by Co., Ltd.) 0.02 mass% was added to make the hydrophobic part. Subsequently, sodium carboxymethylcellulose (CMC1380, manufactured by Daicel Chemical Industries, Ltd.) 4.0% by mass, synthetic hydrotalcite (Alkamak, manufactured by Kyowa Chemical Industry Co., Ltd.) 0.2% by mass, partially neutralized polyacrylic acid ( Aronbis AH106X (manufactured by Toagosei Co., Ltd.) (6.0% by mass) was mixed with concentrated glycerin (Sakamoto Pharmaceutical Co., Ltd.) (20.0% by mass) to obtain a hydrophilic portion. The hydrophobic part and the hydrophilic part were mixed, and the remainder of the purified water was further added and kneaded until uniform to obtain a water-based adhesive coating solution.

<Non-aqueous adhesive coating solution>
The compounding amount in the table is used, 10 mass% of 1,3-butylene glycol (manufactured by Daicel Chemical Industries, Ltd.) is heated and dissolved, and sodium edetate (Chillest 2BST, manufactured by Kirest Corporation) is 0.5 mass%. Add 0.5% by mass of potassium aluminum sulfate (manufactured by Junsei Kagaku Co., Ltd.), appropriate amount of sodium hydroxide (manufactured by Tokyo Ohka Kogyo Co., Ltd.) and the remaining amount of n-butyl methacrylate acrylate copolymer (Laudham, Dow Chemical Co.). The mixture was kneaded until uniform, and a non-aqueous adhesive coating solution was obtained.

(Evaluation method)
[Measurement of blood flow value]
The patch of each example was affixed to the left and right calves of three panelists, and blood flow values were measured with a laser Doppler blood flow meter (PERIFLUX, manufactured by PERIMED). The average value of blood flow value 15 to 25 minutes after application is the average blood flow value (after 20 minutes), the average value of blood flow value 55 to 65 minutes after application is the average blood flow value (after 60 minutes), The average value of blood flow values from 115 to 125 minutes after application was defined as the average blood flow value (after 120 minutes). In addition, each average blood flow value was shown as a relative value when the average blood flow value for 30 minutes measured in the state which does not stick a patch is set to 100.

[Satisfaction of cold feeling or warm feeling]
The patch of each example was affixed to the left and right calves of three panelists all day and night, and each panelist evaluated the feeling of cooling or warmth satisfaction of the patch according to the following evaluation criteria.
5 points: very satisfied 4 points: quite satisfied 3 points: slightly satisfied 2 points: slightly satisfied 1 point: not satisfied

[Effect of improving edema]
The patch of each example was applied to the left and right calves of three panelists all day and night, and each paneler evaluated the effect of improving edema according to the following evaluation criteria. The evaluation points of the three panelists were averaged and classified as 4 points or more: ◎, 3 points or more and less than 4 points: ◯, 2 points or more and less than 3 points: Δ, less than 2 points: x.
5 points: greatly improved 4 points: considerably improved 3 points: slightly improved 2 points: slightly improved 1 point: not improved

[Stimulation of protrusions]
The patch of each example was affixed to the left and right calves of three panelists all day and night, and each panelist evaluated the sensation of protrusions according to the following evaluation criteria. The evaluation points of the three panelists were averaged and classified as 4 points or more: ◎, 3 points or more and less than 4 points: ◯, 2 points or more and less than 3 points: Δ, less than 2 points: x.
5 points: I felt a sense of stimulation 4 points: I felt a lot of irritation 3 points: I felt a sense of irritation 2 points: I felt a little irritation 1 point: I didn't feel irritation

[Satisfaction with protrusion stimulation]
The patch of each example was affixed to the left and right calves of three panelists all day and night, and each panelist evaluated the degree of satisfaction with projection stimulation according to the following evaluation criteria. The evaluation points of the three panelists were averaged and classified as 4 points or more: ◎, 3 points or more and less than 4 points: ◯, 2 points or more and less than 3 points: Δ, less than 2 points: x.
5 points: A very satisfactory stimulation was obtained 4 points: A fairly satisfactory stimulation was obtained 3 points: A satisfactory stimulation was obtained 2 points: A slightly satisfactory stimulation was obtained 1 point : Satisfactory stimulation could not be obtained

(Examples 1-12, 14-23)
According to the composition shown in Tables 1 to 3, each composition of the resin composition was dispersed and mixed with a mixer to prepare a resin composition slurry. Using the same manufacturing apparatus as the support manufacturing apparatus 100 shown in FIG. 4, the prepared resin composition slurry was used as a base material (material: polyester fiber, thickness: 0.5 mm, dimensions: 12 cm × 9 cm, manufactured by Japan Vilene Co., Ltd.). ) In a matrix. In application, the resin composition slurry was arranged in a matrix so as to have the number of protrusions shown in the table. The resin composition slurry was applied in a substantially circular shape having a diameter of 2.2 mmφ.
Hot air (120 ° C.) was blown onto the substrate on which the resin composition slurry was applied, and the resin composition slurry was dried. In this way, a support provided with a protrusion having a diameter of 3.0 mmφ and a height of 2.5 mm was obtained.
The pressure-sensitive adhesive shown in the table was applied to the protrusion forming surface of the obtained support with a thickness of 1.5 mm. The obtained patch was evaluated for blood flow measurement, cooling or warmth satisfaction, edema improvement effect, protrusion stimulation, and protrusion stimulation satisfaction, and the results are shown in Tables 1-3. . In addition, the quantity of the projection part in a table | surface shows the quantity of the projection part per 4 cm < ² > (2cm square) (it is the same below).
Examples 17, 19, 20, 22, and 23 are reference examples.

(Example 13)
After applying the adhesive, a patch was obtained in the same manner as in Example 1 except that the adhesive was dried in a constant temperature bath at 90 ° C. The obtained patch was evaluated for blood flow measurement, cooling or warmth satisfaction, edema improvement effect, protrusion stimulation, and protrusion stimulation satisfaction, and the results are shown in Table 2.

(Comparative Example 1)
A patch was obtained in the same manner as in Example 1 except that a support having no protrusion was used. The obtained patch was evaluated for blood flow measurement, cooling or warmth satisfaction, edema improvement effect, protrusion stimulation, and protrusion stimulation satisfaction, and Table 3 shows the results.

(Comparative Example 2)
A patch was obtained in the same manner as in Example 1 except that only one protrusion was provided on the substrate. The obtained patch was evaluated for blood flow measurement, cooling or warmth satisfaction, edema improvement effect, protrusion stimulation, and protrusion stimulation satisfaction, and Table 3 shows the results.

(Comparative Example 3)
A patch was obtained in the same manner as in Example 1 except that the component (A) and the blood flow promoter were not blended in the resin composition. The obtained patch was evaluated for blood flow measurement, cooling or warmth satisfaction, edema improvement effect, protrusion stimulation, and protrusion stimulation satisfaction, and Table 3 shows the results.

(Comparative Example 4)
A patch was obtained in the same manner as in Example 1 except that the component (A) was not blended in the resin composition. The obtained patch was evaluated for blood flow measurement, cooling or warmth satisfaction, edema improvement effect, protrusion stimulation, and protrusion stimulation satisfaction, and Table 3 shows the results.

(Comparative Example 5)
A patch was obtained in the same manner as in Example 1 except that no blood flow promoter was added to the resin composition. The obtained patch was evaluated for blood flow measurement, cooling or warmth satisfaction, edema improvement effect, protrusion stimulation, and protrusion stimulation satisfaction, and Table 3 shows the results.

As the results of Examples 1 to 23 in Tables 1 to 3, the patch of the present invention had a protrusion irritation feeling of “◯” or more. In addition, the degree of satisfaction with the stimulation of the protrusion was “Δ” or more. On the other hand, in Comparative Examples 1 and 2 in Table 3, the degree of protrusion stimulation and the degree of protrusion satisfaction were “x”. From this, it was found that the provision of a plurality of protrusions can improve the protrusion stimulation effect and the protrusion stimulation satisfaction.
In the comparison between Example 1 and Comparative Examples 3 to 5, Example 1 shows that the average blood flow value (after 60 minutes) and the average blood flow value (after 120 minutes) are the component (A) and the blood flow promoter. It was significantly improved over Comparative Example 3 in which no component was added, Comparative Example 4 in which component (A) was not added, and Comparative Example 5 in which a blood flow promoter was not added. In addition, in Example 1, the evaluation result of the cooling sensation and edema improvement effect was improved as compared with Comparative Examples 3-5.
From the above results, it was found that the patch of the present invention can synergistically improve the effect of the drug by including the component (A) in the protrusion.

8 Patch 10 Support 12 Base 20 Protrusion 30 Adhesive Layer

Claims (2)

A sheet-like support provided with a plurality of protrusions on one surface, and an adhesive layer provided on the one surface and containing a blood flow promoter,
The protrusion is composed of (A) component: germanium and / or black silica , (B) component: resin, (C) component: foaming agent, and (D) component: inorganic filler other than the (A) component. A resin composition containing
The compounding amount of the component (A) in the resin composition is 0.0005 to 20% by mass, and the total amount of the component (A) and the component (D) in the resin composition is 50 to 70% by mass. And
The protrusion is characterized in that the retention obtained by the following formula (1) is 40 to 80% .
Retention rate (%) = H2 ÷ H1 × 100 (1)
In formula (1), H2 is the height (mm) when the projection is pressed with 0.9 kg, and H1 is the height (mm) of the projection before pressing. The patch according to claim 1, wherein a mass ratio represented by the component (C) / the component (A) is 0.05 to 4000 in the resin composition .

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