JP5997451B2 - Vial cap - Google Patents

Description

  The present invention relates to a vial used as a reaction container or storage container for a drug, and more specifically, a rubber stopper of a vial having a flange-shaped mouth portion and fitted with a rubber stopper in the mouth portion to be closed. It is related with the cap for fixing.

  The vial of the above type is closed by fitting a rubber stopper to the mouth when the medicine is accommodated, and then sealing with an aluminum cap or a resin cap around the mouth (Patent Document 1, Patent) Reference 2). However, if the rubber plug is attached to the heating device with the PEEK tube punctured, there will be problems such as vacuum leakage from the gap between the PEEK tube and the rubber plug, or the positional relationship with the heater will shift and the heating conditions will fluctuate. there were.

  Therefore, as shown in FIG. 5, the present inventor has a socket member 3 that is attached by being snap-fitted to the mouth portion 22 of the vial 2 closed by the rubber stopper 1, and is screwed into the socket member 3. The socket member 3 includes a tubular portion 31 that extends upward from the mouth portion 22 of the vial 2 when attached, and the distal end portion 41 of the plug member 4 is the vial 2. The rubber plug 1 is fixed by screwing into the tubular portion 31 of the socket member 3 until it abuts against the rubber plug 1, and a plurality of insertion holes 43 are formed in the plug member 4 so that the PEEK tube can be punctured into the rubber plug 1 in this state. Has already been invented, and a patent application (Japanese Patent Application No. 2009-98880) has been filed.

  By using a vial cap as shown in FIG. 5, the above-described problems of vacuum leakage and fluctuations in heating conditions were solved. However, when this vial cap is used for a vial 2 in which the rubber stopper 1 of the mouth portion 22 is not sealed with an aluminum cap or a resin cap (not shown), the rubber stopper 1 is removed when the plug member 4 is removed. 4 sticks to the end surface 42 of the distal end portion 41 and rotates together with the plug member 4 so as to come off from the mouth portion 22 of the vial 2, and in some cases, there is a problem that the tube portion 31 of the socket member 3 comes out. understood. In order to solve this problem, it is conceivable to reduce the area of the end surface 42 of the plug member 4 or to prevent the sticking with the rubber plug 1 by applying Teflon (registered trademark) processing to the end surface 42. None of the above problems could be solved sufficiently.

Japanese Patent Laid-Open No. 08-230928 JP 2008-050057 A

  An object of the present invention is to provide another method for solving the problem that the rubber stopper is detached from the mouth of the vial together with the plug member when the plug member is removed in the above-described vial cap.

  As a result of intensive studies to solve the above problems, the present inventors have found that the above problems can be solved by devising the shape of the inner wall in the tubular portion of the socket member of the vial cap. It came to be completed.

  That is, the present invention comprises a socket member that is attached to a mouth portion of a vial closed with a rubber stopper, and a plug member that is inserted into and engaged with the socket member. An upwardly extending tubular portion is provided, and when the plug member is inserted into the tubular portion of the socket member and engaged with the socket member, the tip of the plug member is brought into contact with the rubber stopper of the vial to fix the rubber stopper. The vial cap is characterized in that a narrowed portion is provided in the tubular portion of the socket member to prevent the rubber stopper from coming out of the tubular portion.

According to the present invention, even when a rubber stopper is attached to the tip of the plug member when the plug member of the vial cap is removed, the rubber stopper is prevented from passing through the tubular portion of the socket member by the narrowed portion. Thus, since the tip of the plug member can pass through the constricted portion, the rubber stopper is peeled off from the plug member, and the rubber stopper can be prevented from coming off from the mouth of the vial.
In addition, when the vial cap of the present invention is used while attached to the vial, it is possible to secure a sufficient sealing property of the rubber stopper, so that it is not necessary to apply an aluminum cap to the vial. Therefore, the vial cap of the present invention can be used as an alternative to the aluminum cap when the vial is used as a temporary storage container.

It is a longitudinal cross-sectional view which shows one Embodiment of the vial cap of this invention. It is a longitudinal cross-sectional view which shows other embodiment of the vial cap of this invention. It is a longitudinal cross-sectional view which shows other embodiment of the vial cap of this invention. It is the perspective view which looked at the socket member of the vial cap of FIG. 1 from the bottom part. It is a longitudinal cross-sectional view which shows the vial cap proposed by the prior application.

  Hereinafter, embodiments of the vial cap of the present invention will be described with reference to the drawings, but the present invention is not limited to the embodiments.

  FIG. 1 is a longitudinal sectional view showing an embodiment of the vial cap of the present invention. In FIG. 1, the same reference numerals are given to the same elements as those of the vial cap shown in FIG. In particular, in FIG. 1, the configuration of the rubber stopper 1, the vial 2, and the plug member 4 is the same as that in FIG. 5, but the socket member 3 includes a flange 34 that protrudes inwardly from the side wall inside the tubular portion 31. 5 is different from FIG. 5 in that a narrowed portion is formed. Since the narrowed portion has a size larger than the tip portion 41 having a small diameter of the plug member 4, the narrowed portion allows passage of the tip portion 41, but has a size narrower than the width of the upper surface portion 12 of the rubber plug 1. Therefore, even when the upper surface portion 12 of the rubber plug 1 is stuck to the end surface 42 of the plug member 4 when the plug member 4 is removed, the plug member 4 and the rubber plug 1 are peeled by contacting the upper surface portion 12 of the rubber plug 1. Therefore, it is possible to prevent the rubber plug 1 from coming out of the mouth portion 22 or passing through the tubular portion 31 and coming out of the socket member 3. The object of the present invention can be achieved if the size of the passage of the narrowed portion is roughly 0.1 mm or more smaller than the maximum width of the upper surface portion 12 of the rubber plug 1.

  Hereinafter, the embodiment of FIG. 1 will be described in more detail. In FIG. 1, the vial 2 includes a cylindrical main body 21 that is tapered toward the mouth portion 22, as is well known, and a flange-shaped mouth formed so as to project outward in an annular shape at the tip thereof. The unit 22 is provided. The rubber plug 1 includes a small-diameter cylindrical insertion portion 11 that is fitted into the mouth portion 22, and a large-diameter disk-like upper surface portion 12 that is placed in contact with the end surface 23 of the flange-like mouth portion 22. And has a substantially mushroom-like longitudinal cross-sectional shape.

  In the vial cap of FIG. 1, the socket member 3 includes a tubular portion 31 that engages with the plug member 4, and an attachment portion 32 that arranges the tubular portion 31 so as to extend above the mouth portion 22 of the vial 2. is necessary. As long as this requirement is satisfied, the shape of the socket member 3 is not particularly limited, and the cross-sectional shape of the tubular portion 31 may be other than circular, but the socket member 3 usually has a cylindrical shape. Similarly, the tubular portion 31 is also preferably cylindrical. Therefore, hereinafter, as shown in FIG. 4, description will be made on the assumption that the socket member 3 and its tubular portion 31 are cylindrical.

  The mounting portion 32 may be provided with an inwardly extending portion 33 having an inner diameter slightly smaller than the outer diameter of the flange-shaped mouth portion 22 of the vial 2 so as to be fitted to the mouth portion 22 in a snap manner. Further, as shown in FIG. 4, the side wall of the socket member 3 is partially cut away to form a slot 35, and the mouth portion 21 of the vial 2 is inserted into the slot 35 from the side to snap into the socket member 3. You may enable it to fit. Moreover, you may attach the socket member 3 to the opening part 21 of the vial 2 using a suitable fastener. In addition, as shown in FIG. 4, in order to improve the operativity of the socket member 3, you may provide an unevenness | corrugation in the outer peripheral surface 36 by a knurling process, a roughening process, etc. FIG. In the example of FIG. 4, the flange 34 is formed so as to continuously project in an annular shape from the inner peripheral wall of the socket member 3 inward, but intermittently if the narrowed portion intended by the present invention can be formed. For example, the flange 34 may be formed as a plurality of intermittent arc-shaped protruding portions. If the flange 34 protrudes inward by 0.05 mm or more from the outer periphery of the upper surface portion 12 of the rubber plug 1, the object of the present invention can be achieved.

  In the vial cap of FIG. 1, a screw thread is provided on the inner peripheral wall of the cylindrical tubular portion 31 of the socket member 3 so as to be screwed with the screw thread provided on the outer peripheral wall of the cylindrical plug member 4. Is formed. Therefore, after the socket member 3 of FIG. 1 is attached to the mouth portion 22 of the vial 2 and arranged so that the central axes of the both are substantially coincident, the plug member 4 is screwed into the tubular portion 31 of the socket member 3, thereby The distal end 41 of 4 passes through the constriction formed by the flange 34 and the end face 42 comes into contact with the upper surface of the rubber stopper 1, whereby the rubber stopper 1 can be fixed and the vial 2 can be sealed. In this state, the contents may be reacted by being mounted in the heating device, or the contents may be temporarily stored. At this time, the PEEK tube may be left pierced into the rubber plug 1 through the insertion hole 43. Thereafter, when the plug member 4 is loosened by rotating it reversely in order to use the contents, even if the end surface 42 of the plug member 4 is stuck to the upper surface portion 12 of the rubber plug 1, it is formed with the flange 34. Since the rubber stopper 1 is prevented from coming out of contact with the narrowed portion, the rubber stopper 1 does not come off the vial 2 against the user's intention when the plug member 4 is removed.

  The engagement between the socket member 3 and the plug member 4 in FIG. 1 is performed by screwing in FIG. 1, but by pushing the plug member 4 into the socket member 3, a snap-type engagement between the two is performed. You may do it. In the case of this snap-type fitting method, for example, a structure in which the rubber plug 1 is pressed by fitting the plug member 4 into the socket member 3 with one touch can be employed.

  FIG. 2 is a longitudinal sectional view showing another embodiment of the vial cap of the present invention, and the same elements as those in FIG. 1 are denoted by the same reference numerals. The vial cap of FIG. 2 has a narrowed portion formed by making the threaded portion of the tubular portion 31 of the socket member 3 smaller in diameter than the portion below it, and thus the vial cap of FIG. Different. As a result, in FIG. 2, a stepped portion 37 projecting inward is formed on the inner peripheral wall of the socket member 3, so that when the plug member 4 is removed, the end surface 42 of the plug member 4 should be the upper surface of the rubber plug 1. Even if it sticks to the portion 12, the rubber plug 1 is prevented from coming out of contact with the constricted portion, that is, the step portion 37. The step 37 can usually achieve the object of the present invention as long as it protrudes inward by 0.05 mm or more from the outer periphery of the upper surface portion 12 of the rubber plug 1.

  FIG. 3 is a longitudinal sectional view showing still another embodiment of the vial cap of the present invention, and the same elements as those in FIG. 1 are denoted by the same reference numerals. The vial cap of FIG. 3 is configured such that a thread is provided on the outer peripheral surface of the socket member 3 and a screw thread is provided on the inner peripheral surface of the plug member 4, thereby engaging the two by screwing together. Thus, it is different from the vial cap of FIG. Of course, it can also be set as the structure engaged instead of screwing by both fitting by snap type. In the case of this snap-type fitting method, for example, a structure in which the rubber plug 1 is pressed by fitting the plug member 4 into the socket member 3 with one touch can be employed. In FIG. 3, similarly to FIG. 2, the step portion 37 is formed on the inner wall of the socket member 3, so that when the plug member 4 is removed, the end surface 42 of the plug member 4 should be the upper surface portion 12 of the rubber plug 1. Even if it sticks to the rubber plug 1, it is prevented that the rubber plug 1 comes into contact with the narrowed portion formed by the step portion 37 and comes out.

  In the vial cap of the present invention, both the socket member and the plug member can be made of an appropriate material such as metal or plastic, but it is preferable that the vial cap is made of plastic. The vial cap of the present invention is not limited to the illustration and the embodiment described above, and those skilled in the art can make various modifications other than the above by replacing each element with an equivalent. Needless to say.

  The vial cap of the present invention is useful when a plurality of drugs are contained in a vial for reaction, or when a drug is contained in a vial for temporary storage, and the synthesis and storage of various other compounds including radiopharmaceuticals. In addition to the above applications, it can be widely used in various fields in which vials are used.

DESCRIPTION OF SYMBOLS 1 Rubber stopper 11 Insertion part 12 Upper surface part 2 Vial 21 Main body 22 Mouth part 23 End surface 3 Socket member 31 Tubular part 32 Attachment part 33 Inward projecting part 34 鍔 (constriction part)
35 slot 36 outer peripheral surface 37 stepped portion (constriction portion)
4 Plug member 41 Tip 42 End face 43 Insertion hole

Claims (7)

The socket member (3) is attached to the mouth (22) of the vial (2) closed by the rubber stopper (1), and the plug member (4) is inserted into and engaged with the socket member (3). The socket member (3) includes a tubular portion (31) extending upward from the mouth portion (22) of the vial (2) when attached, and the plug member (4) is provided with the tubular portion (31) of the socket member (3). ) When the rubber plug (1) is inserted into the socket member (3) and engaged with the socket member (3), the rubber plug (1) is fixed by bringing its tip (41) into contact with the rubber plug (1) of the vial (2). A rubber cap provided with a narrowed portion (34, 37) through which the tip end portion (41) of the plug member (4) passes in the tubular portion (31) of the socket member (3). (1) comes out of the tubular part (31) Preventing vial cap, characterized in that the. The vial cap according to claim 1, wherein the narrowed portion is provided by forming a ridge (34) projecting inwardly from an inner peripheral wall of the tubular portion (31). The vial cap according to claim 2, wherein the spear (34) is continuously provided in an annular shape. The vial cap according to claim 2, wherein the ridge (34) is provided intermittently. The vial cap according to claim 1, wherein the plug member (4) is engaged by being screwed into the socket member (3). The vial cap according to claim 1, wherein the plug member (4) engages with the socket member (3) by snap-fitting. The vial cap according to claim 1, wherein the socket member (3) is attached by snap-fitting to the mouth (22) of the vial (1).

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