JP6013138B2 - Foam aerosol type skin external composition - Google Patents

Description

The present invention relates to a preparation technique useful for a foamy aerosol type skin external composition, and more particularly, to a foamy aerosol type skin external composition preparation technique that generates cracking sound capable of suppressing irritation to the skin.

Foam-like external composition for skin can efficiently absorb percutaneously effective active ingredients such as wrinkles and stains by utilizing the high surface activity of the external composition for skin at the contact interface with the skin. Therefore, it is widely applied to pack cosmetics and the like. Moreover, in order to make it foamy, an aerosol type using liquefied natural gas or carbon dioxide (Patent Document 1) is the mainstream. Among them, there is one that emits crackling sound immediately after jetting the composition for external use from an aerosol container by increasing the blending amount of liquefied natural gas (Patent Document 2). With this sound, it is possible to enhance the user's actual feeling of the effect of cosmetics, enjoy the use of cosmetics, and differentiate products.

However, foam aerosol type skin external compositions that emit cracking noise have a high possibility of developing skin irritation such as stinging and inflammation due to the large amount of liquefied natural gas, especially the skin. It was difficult to use for delicate sensitive skin.

On the other hand, a polymer such as an alkyl acrylate copolymer emulsion or polyvinylpyrrolidone is applied to a peel-off type pack cosmetic (a composition for external application of the skin is applied thinly to the skin, dried to form a sheet, and then peeled off from the skin. There are many examples used in (pack cosmetics) (Patent Document 3). In addition, in order to give a moist feel to the skin, there is a report in which only polyvinylpyrrolidone is used in a foamy aerosol type skin external composition (Patent Document 4). However, there are no examples of foamy aerosol type skin external compositions that generate cracking noise, and this application reduces skin irritation and is very effective for sensitive skin patients with delicate skin. It was not known at all.

JP 2009-191042 A Japanese Patent Laid-Open No. 11-100308 Japanese Patent Laid-Open No. 10-245319 JP 2008-37773 A

The present invention has been made under such circumstances, and the active ingredient can be efficiently transdermally absorbed, and the skin irritation caused by liquefied natural gas is reduced. It is an object to provide a composition for external use.

In view of such a situation, the present inventors pay attention to a polymer, a propellant, a surfactant, an oil agent, etc. that have a great influence on the effect of transdermal absorption, skin irritation, and formulation stability. As a result of investigating these raw materials that can be used in the cosmetics field and eagerly researching for a new formulation, the inventors have found that the following new formulation can solve the problem and completed the present invention. That is, the present invention is as follows.

<1> Foam aerosol type skin external composition containing an alkyl acrylate copolymer emulsion and polyvinylpyrrolidone.
<2> The foamy aerosol type external composition for skin according to <1>, wherein a cracking sound is emitted immediately after injection.
<3> The foamy aerosol-type skin external composition according to <1> or <2>, which is a pack cosmetic.
<4> Any one of <1> to <3>, wherein the alkyl acrylate copolymer emulsion is an acrylic acid / ethyl acrylate / 2-ethylhexyl acrylate / methyl methacrylate copolymer emulsion The foamy aerosol type skin external composition as described.
<5> The foam aerosol-type skin external application according to any one of <1> to <4>, wherein the propellant is a liquefied natural gas at 25 ° C. and a pressure of 0.1 to 0.35 MPa. Composition.
<6> The foamy aerosol type skin external composition as described in any one of <1> to <5>, which contains a hydroxyalkyl cellulose polymer.

ADVANTAGE OF THE INVENTION According to this invention, the active ingredient can be efficiently percutaneously absorbed and the foam-type aerosol external skin composition with the high effect effect | action which reduced the skin irritation by liquefied natural gas can be provided.

<Alkyl acrylate copolymer emulsion used in the present invention>
The foamy aerosol type skin external composition of the present invention contains an alkyl acrylate copolymer emulsion as an essential component. This component is an emulsion of one or more polymers or copolymers selected from water-insoluble polymers and / or hydrophobic polymers. Here, the water-insoluble polymer means a polymer that does not substantially dissolve in water or soften with water. Specifically, acrylic acid, ethyl acrylate, 2-ethylhexyl acrylate, and methyl methacrylate are used. Preferred examples can be given. Such a water-insoluble polymer can be used without particular limitation as long as it is usually used in cosmetics. As a copolymer, even if it is a normal random copolymer, a graft copolymer can be used. It may be a polymer, a block copolymer, or a core / shell type copolymer. Preferable commercial products include poly joint JN (alkyl acrylate copolymer emulsion; resin content 50% by weight) manufactured by Taisei Kako Co., Ltd. As content, 0.001-10 mass% is preferable in conversion of the resin content of an emulsion with respect to the whole cosmetics, and 0.01-1 mass% is more preferable. When the amount of the polymer in the emulsion is too large, a foam state is not formed, and when it is too small, the skin irritation suppressing effect is not sufficiently exhibited.

<Polyvinylpyrrolidone used in the present invention>
The foamy aerosol type skin external composition of the present invention contains polyvinylpyrrolidone as an essential component. Those having a weight average molecular weight of 50,000 to 500,000 as determined by viscosity measurement are preferred. As content, 0.1-5 mass% is preferable with respect to the whole cosmetics, and 1-3 mass% is more preferable.

<Liquefied natural gas used in the present invention>
The foamy aerosol type skin external composition of this invention contains the ejection agent which is gas as an essential component. Examples of the propellant include liquefied natural gas and compressed gas, and are not particularly limited as long as they are normally used as a propellant in an aerosol or the like. Among them, liquefied natural gas is preferable, and the pressure is 0. 25 to 0.35 MPa is preferable. Specifically, a mixture of butane: propane = 100: 0 to 70:30 is preferable, and a mixture of 100: 0 to 80:20 is more preferable. 1-50 mass% is preferable and, as for content of this propellant with respect to the whole cosmetics, 3-10 mass% is more preferable.

<Hydroxyalkyl cellulose polymer used in the present invention>
The hydroxyalkyl cellulose polymer used in the foamy aerosol type skin external composition of the present invention is preferably a lower alkyl (C1-C8) hydroxyalkyl cellulose such as hydroxymethyl cellulose, hydroxyethyl cellulose, or hydroxypropyl cellulose, and hydroxyethyl cellulose. Is most preferred. As a preferable commercial item, Sumitomo Seika Co., Ltd. HEC SZ-25 is mentioned. As content, 0.001-1 mass% is preferable with respect to the cosmetics whole, and 0.01-0.2 mass% is more preferable.

<Foam aerosol-type skin external composition of the present invention>
The foamy aerosol type skin external composition of the present invention is characterized by being foamy when the skin external composition is ejected. Moreover, it is also characterized by generating a cracking sound immediately after injection. Among cosmetics, it is preferable to be applied to cosmetics whose use feeling is important, and pack cosmetics are more preferable.

In the foamy aerosol type skin external composition of the present invention, in addition to the above-mentioned components, optional components usually used in cosmetics and skin external medicines can be contained. Examples of such optional ingredients include macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, and hardened coconut oil. Oil, wax, liquid paraffin, squalane, pristane, ozokerite, paraffin, ceresin, petrolatum, oil, wax, liquid wax, liquid paraffin, squalane, bean wax, candelilla wax, carnauba wax, ibotarou, lanolin, reduced lanolin, hard lanolin , Hydrocarbons such as microcrystalline wax, higher fatty acids such as oleic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid, cetyl alcohol, stearyl alcohol, isostearyl alcohol, Higher alcohols such as alcohol, octyldodecanol, myristyl alcohol, cetostearyl alcohol, cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, diacid malate Isostearyl, ethylene glycol di-2-ethylhexanoate, neopentyl glycol dicaprate, glycerin di-2-heptylundecanoate, glycerin tri-2-ethylhexanoate, tri-2-ethylhexanoate trimethylolpropane, triisostearin Synthetic ester oils such as acid trimethylolpropane, tetra-2-ethylhexanoic acid pentane erythritol, dimethylpolysiloxane, methylphenylpolysiloxane, diphenyl Linear polysiloxanes such as polypolysiloxane, cyclic polysiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexanesiloxane, amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, fluorine-modified Oil agents such as silicone oils such as modified polysiloxanes such as polysiloxane, fatty acid soap (sodium laurate, sodium palmitate, etc.), anionic surfactants such as potassium lauryl sulfate, alkyl sulfate triethanolamine ether, stearyl trimethyl chloride Cationic surfactants such as ammonium, benzalkonium chloride, laurylamine oxide, betaine surfactants (alkyl betaines, amide betaines, sulfobetaines, etc.) ), Imidazoline-based amphoteric surfactants (2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt, etc.), amphoteric surfactants such as acylmethyltaurine, sorbitan fatty acid esters (sorbitan monoester) Stearate, sorbitan sesquioleate, etc.)
Glycerin fatty acids (such as glyceryl monostearate), propylene glycol fatty acid esters (such as propylene glycol monostearate), hydrogenated castor oil derivatives, glycerin alkyl ethers, POE sorbitan fatty acid esters (POE sorbitan monooleate, monostearic acid) Polyoxyethylene sorbitan, etc.), POE sorbite fatty acid esters (POE-sorbite monolaurate, etc.), POE glycerin fatty acid esters (POE-glycerin monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate). etc)
POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkylphenyl ethers (POE nonylphenyl ether, etc.), Pluronic types, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Te Tronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.), nonionic surfactants such as sucrose fatty acid ester, alkyl glucoside, polyethylene glycol, glycerin, 1,3-butylene glycol Erythritol, sorbitol, xylitol, maltitol, propylene glycol, dipropylene glycol, diglycerin, isoprene glycol, 1,2-pentanediol, 2,4-hexylene glycol, 1,2-he Polyhydric alcohols such as sundiol, 1,2-octanediol, moisturizing ingredients such as sodium pyrrolidonecarboxylate, lactic acid, sodium lactate, guar gum, quince seed, carrageenan, galactan, gum arabic, pectin, mannan, starch, xanthan gum , Curdlan, methylcellulose, hydroxyethylcellulose, carboxymethylcellulose, methylhydroxypropylcellulose, chondroitin sulfate, dermatan sulfate, glycogen, heparan sulfate, hyaluronic acid, sodium hyaluronate, tragacanth gum, keratan sulfate, chondroitin, mucoitin sulfate, hydroxyethyl guar gum, carboxy Methyl guar gum, dextran, keratosulfate, locust bean gum, succinoglucan, caronic acid, chitin, Thickeners such as tosan, carboxymethyl chitin, agar, polyvinyl alcohol, polyvinyl pyrrolidone, carboxy vinyl polymer, alkyl-modified carboxy vinyl polymer, sodium polyacrylate, polyethylene glycol, bentonite, surface may be treated, mica, Powders such as talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, silicic anhydride (silica), aluminum oxide, barium sulfate, surface may be treated, bengara, yellow iron oxide, black iron oxide, Cobalt oxide, ultramarine, bitumen, titanium oxide, zinc oxide inorganic pigments, surface may be treated, pearlescent agents such as titanium mica, fish phosphorus foil, bismuth oxychloride, red may be raked 202, Red 228, Red 226, Yellow 4, Blue 40 No. 4, Yellow No. 5, Red No. 505, Red No. 230, Red No. 223, Orange No. 201, Red No. 213, Yellow No. 204, Yellow No. 203, Blue No. 1, Green No. 201, Purple No. 201, Red No. 204 Organic dyes such as polyethylene powder, polymethyl methacrylate, nylon powder, organic powders such as organopolysiloxane elastomers, paraaminobenzoic acid UV absorbers, anthranilic acid UV absorbers, salicylic acid UV absorbers, cinnamon Acid UV absorber, benzophenone UV absorber, sugar UV absorber, 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole, 4-methoxy-4′-t-butyldibenzoylmethane ultraviolet absorbing agents and the like, ethanol, lower alcohols such as isopropanol, vitamin a or a derivative thereof, vitamin B Hydrochloride, vitamin _{B 6} tripalmitate, vitamin _{B 6} dioctanoate, vitamin _{B 2} or derivatives thereof, vitamin _{B 12,} vitamin B such as vitamin _{B 15} or a derivative thereof, alpha-tocopherol, beta-tocopherol, .gamma.-tocopherol, Preferable examples include vitamin E such as vitamin E acetate, vitamin D, vitamin H, pantothenic acid, panthetin, pyrroloquinoline quinone and the like.

<Production Example of Foam Aerosol Type Skin External Composition of the Invention>
According to the formulation shown below, the foamy aerosol type skin external composition (Example 1) of this invention was created. That is, the components contained in A are heated and dissolved at 80 ° C., and the components contained in B are gradually added to A with stirring to prepare a composition for external use on the skin, and this is filled in an aerosol container. Example 1 was obtained.

Compared to Example 1 , Examples 2 and 3, in which polyvinylpyrrolidone was changed or deleted , Comparative Examples 1 and 3 , Comparative Example 2 in which polyvinyl alcohol was substituted , Example 4 in which hydroxyethyl cellulose was changed or deleted , and Comparative Examples 4 and 5 Examples 5, 6 and Comparative Examples 6 and 7 in which the acrylic acid / ethyl acrylate / acrylic acid 2-ethylhexyl / methyl methacrylate copolymer emulsion was changed or deleted, and Examples 7 and 8 in which the liquefied natural gas was changed Comparative Examples 9 and 10 in which the pressure of liquefied natural gas was changed and Comparative Example 11 in which carbon dioxide gas was substituted were also prepared in the same manner. It shows in Tables 1-3.

<Test Example 1 Transdermal absorbability evaluation>
After providing six 1 cm × 1 cm portions on the inner side of the forearm of 10 panelists and applying 7 μL of each of the prepared foam-type aerosol external skin test compositions to each panel and allowing to stand at 20 ° C. for 1 hour. The skin was wiped with a cotton wool impregnated with tetrahydrofuran (THF), this cotton wool was extracted three times with 100 ml of THF, and the recovered amount of vitamin E was quantified by high performance liquid chromatography. The recovery rate was defined as transdermal absorbability (the lower the value, the higher the transdermal absorbability). Each test sample was evaluated twice, and the averages are shown in Tables 1 to 3.

<Test Example 2 Skin irritation evaluation>
A skin irritation evaluation on the face was performed on 10 panelists who recognized themselves as sensitive skin. The prepared test sample, which is a foamy aerosol type skin external composition, was applied to the entire face and allowed to stand for 30 seconds to evaluate the irritation felt at that time. The evaluation criteria are shown below. The mode values for 10 people are shown in Tables 1-3.
0: No irritation is felt.
1: Slight irritation is felt.
2: Although there is a stimulus, it is at a usable level.
3: Strongly irritating and unusable level.
<Test Example 3 Usability Evaluation>

A questionnaire was conducted on the cracking sound when the test sample was applied. The evaluation criteria are shown below. The mode values for 10 people are shown in Tables 1-3.
A: A strong cracking sound is felt.
B: A slight cracking sound is felt.
C: There is almost no cracking sound.

A questionnaire was conducted on the moist feeling when applying the test sample. The evaluation criteria are shown below. The mode values for 10 people are shown in Tables 1-3.
A: There is a moist feeling.
B: Somewhat moist.
C: There is no moist feeling.

From the results of Tables 1 to 3, according to the present invention, a foamy aerosol type skin external composition having a high effect of effect, in which the active ingredient can be efficiently percutaneously absorbed and the skin irritation caused by liquefied natural gas is reduced. It turns out that things can be provided.

The present invention relates to a formulation technique useful for a foamy aerosol type skin external composition, and more particularly, to a foamy aerosol type skin external composition formulation technique that generates cracking sound that can suppress irritation to the skin. it can.

Claims (4)

The alkyl acrylate copolymer emulsion is 0.001 to 10% by mass with respect to the whole composition , the polyvinyl pyrrolidone is 0.1 to 5 % by mass with respect to the whole composition, and the hydroxyalkyl cellulose polymer is over the whole composition. A foamy aerosol type skin external composition comprising 0.001 to 1% by mass and liquefied natural gas having a pressure of 0.25 to 0.35 MPa at 25 ° C.   The foamy aerosol type external composition for skin according to claim 1, wherein a cracking sound is emitted immediately after injection.   It is a pack cosmetic, The foamy aerosol type skin external composition of Claim 1 or 2 characterized by the above-mentioned.   The foam according to any one of claims 1 to 3, wherein the alkyl acrylate copolymer emulsion is an acrylic acid / ethyl acrylate / 2-ethylhexyl acrylate / methyl methacrylate copolymer emulsion. Aerosol type skin external composition.