JP6014970B2 - Manufacturing method of low adsorptive packaging material - Google Patents

Description

The present invention is used for a packaging material for packaging contents containing volatile components such as foods and pharmaceuticals. In particular, the present invention is a packaging material for packaging patches, cataplasms and the like having anti-inflammatory analgesics as medicinal ingredients. Further, the present invention relates to a packaging material to which a polyethylene chuck is attached and can be taken in and out many times.

2. Description of the Related Art In food and pharmaceutical packaging materials, there has been a problem that a medicinal component in a content component is adsorbed or sorbed by a sealant layer (polyethylene layer) that is the innermost layer of the packaging material. For this reason, the amount of the adsorbed and sorbed amount is anticipated so that the content component is excessively contained, and the effect and efficacy are stably expressed even after the adsorbed and sorbed. However, when the adsorbed and sorbed components are quite expensive, there is a problem that excessive addition leads to cost increase.

As medicinal ingredients used for patches, cataplasms and the like, methyl salicylate and glycol salicylate have been used. In recent years, drugs containing indomethacin, ketoprofen, flurbiprofen, crotamiton and the like which have high side effects and have few side effects have been used. These drug components are adsorbed or sorbed on the sealant layer which is the innermost layer of the packaging material.

In recent years, there has been a proposal to use an amorphous polyethylene terephthalate resin, a polyacrylonitrile resin, or the like for the sealant layer (Patent Document 1). A polyacrylonitrile resin has a great effect on all components from the viewpoint of adsorptivity due to a narrow intermolecular distance, and is actually used in a pharmaceutical packaging bag.

However, non-crystalline polyethylene terephthalate resin, polyacrylonitrile resin, etc. are very expensive, have a lower heat seal strength than polyethylene-based heat-sealing layers, and cannot be heat-sealed with polyethylene-based chucks. There are many problems.

In addition, there is a proposal that the corona-treated surface of the polyacrylonitrile resin and the corona-treated surface of the chuck body made of linear low-density polyethylene can be heat-sealed (Patent Document 2). However, the strength is about 30 N / 15 mm, and the strength reduction after storage of the contents is unknown.

There is a proposal to form a bag shape by depositing an inorganic oxide on the innermost layer portion and coating the portion with a heat sealant (Patent Document 3). However, polyethylene-based chucks cannot be heat-sealed.

There is also a proposal that can clear low adsorptivity and low elution by using a cyclic olefin in the sealant layer (Patent Document 4). Since it is difficult to provide a thin heat-fusible layer having a thickness of less than 50 μm with a cyclic olefin, and the cost of the resin is high, the design of the cyclic olefin layer causes a significant increase in cost.

JP-A-8-143453 Japanese Patent No. 3559478 Japanese Patent No. 3813278 JP 2005-254508 A

The present invention is to provide a low adsorptive packaging material provided with a low adsorptivity of medicinal components used in patches, cataplasms and the like and a reclose function.

The invention according to claim 1 of the present invention contains a percutaneous absorption agent containing flurbiprofen, and the adsorption amount from the initial value of flurbiprofen is 40 ° C. and 75% RH after 3 months. Ru der 5% when a method for producing a low adsorptive packing material,
The low adsorptive packaging material includes a base material layer (1), a first adhesive layer (2), a polyethylene layer (3), an aluminum foil layer (4), a second adhesive layer (5), and a polyolefin sealant layer. (6) It is the structure laminated | stacked in order, Moreover, the said 2nd contact bonding layer (5) is the thickness of 0.1 micrometer to 0.5 micrometer, and is 1 liquid aromatic tolylene diisocyanate And
The method for producing a low adsorptive packaging material, wherein the aluminum foil layer (4) and the sealant layer (6) are bonded together by an extrusion laminating method through the second adhesive layer (5). .

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The invention according to claim 2 of the present invention is the method for producing a low-adsorbent packaging material according to claim 1, further comprising a reclose function.

The aluminum foil layer (4) and the sealant layer (6) are bonded together by an extrusion laminating method using aromatic tolylene diisocyanate as an adhesive. By this method, the laminate strength can be maintained, and the adhesive layer can be made thin without deterioration of the strength due to the medicinal components of the contents. By thinning the adhesive layer, the amount adsorbed to the adhesive layer through the sealant layer (6) can be reduced.

It is explanatory drawing which shows an example of the low adsorptive packaging material of this invention. It is explanatory drawing which shows an example of the low adsorptive packaging material of this invention.

The best mode for carrying out the present invention will be specifically described below.

FIG. 1 is an explanatory view showing an example of the low adsorptive packaging material of the present invention. It is sectional drawing which shows an example of the low adsorptive packaging material of this invention.

The substrate layer (1) is not limited as long as it is a film that can be used as a printing substrate. Stretched films such as polyethylene terephthalate (PET) film, stretched polypropylene (OPP) film, stretched nylon (ONy) film, and alumina or silica There are no particular restrictions on the thickness of various films, but the thickness of various films is 30 μm or less for PET films, 20 μm to 40 μm for OPP films, and 10 μm for ONy films. About 30 μm is appropriate.

The base material layer (1) and the polyethylene layer (3) are laminated by extruding and laminating the polyethylene layer (3) via the first adhesive layer (2) . The adhesive used for the first adhesive layer (2) is not particularly limited as long as it is an adhesive for extrusion lamination, and a two-component curable urethane coating agent, or a polyimine-based or butadiene-based one-component curing agent is useful. There, the coating amount after drying of 0.5g / ^{m 2} ~1g / ^m 2 about desirable.

The polyethylene layer (3) is not particularly limited as long as it is a polyolefin resin for extrusion mainly composed of polyolefin, and low density polyethylene (LDPE) is particularly preferable.

The aluminum foil layer (4) is not particularly limited as long as it is a soft aluminum foil used for laminate packaging, and 1N30, 8021 and the like are suitable, and the thickness is optimally 6 μm or more and 20 μm or less.

The aluminum foil layer (4) and the sealant layer (6) are laminated by extruding the sealant layer (6) through the second adhesive layer (5) . As the adhesive used for the second adhesive layer (5) , aromatic type tolylene diisocyanate is used. Since it reacts with moisture in the atmosphere and polymerizes by urethane bonds, it is possible to produce a packaging material that maintains the laminate strength even when the thickness of the adhesive layer is 0.5 μm or less (during drying) and does not deteriorate strength due to medicinal components. The thickness of the adhesive layer is preferably 0.1 μm to 0.5 μm (when dried). Conventionally, using a two-component curable urethane adhesive, the thickness of the adhesive layer was 0.5 μm or more. However, in the present invention, the thickness can be reduced, and the medicinal component can be applied to the adhesive layer. The amount of adsorption can also be reduced.

In addition, by making the aromatic tolylene diisocyanate solid content of the adhesive less than 10%, the gravure coating of the adhesive can be made uniform and the drying can be performed stably at the time of extrusion lamination. . Although there is a relationship with the depth of the gravure plate, the solid content is preferably 3% to 9%. In order to make the thickness of the adhesive layer 0.5 μm or less, it can be set from the solid content of the adhesive and the plate depth of the gravure plate.

Aromatic tolylene diisocyanate is usually used as a curing agent for a two-component curable urethane adhesive. The amount of the curing agent used is 1 to 2% of the main urethane resin. In the present invention, the aromatic tolylene diisocyanate is used alone, that is, in a single solution, and even if the thickness of the adhesive layer is thin, the adhesive strength to aluminum can be sufficiently exhibited.

The sealant layer (6) is a heat-sealing layer for forming a bag shape, and is not particularly limited as long as it is a polyolefin resin for extrusion mainly composed of polyolefin. Low density polyethylene, medium density polyethylene, linear Any low density polyethylene may be used. The thickness is preferably about 20 μm to 35 μm.

The low adsorptive packaging material of the present invention can be produced by the following manufacturing process. The base material layer (1) is sent out from the first paper supply side, and the polyethylene resin is extruded and laminated while applying an adhesive for forming the first adhesive layer (2) to the base material layer (1) . At that time, aluminum foil is fed out from the second paper feeding side and laminated simultaneously with the extruded polyethylene resin. A laminated structure of base material layer (1) / first adhesive layer (2) / polyethylene layer (3) / aluminum foil layer (4) can be formed.

The second adhesive layer (5) , that is, an adhesive made of aromatic tolylene diisocyanate is gravure coated on the aluminum foil surface of the laminated structure prepared up to the above, and the polyethylene resin is extruded and laminated to laminate the sealant layer. . Creating a laminated structure of base material layer (1) / first adhesive layer (2) / polyethylene layer (3) / aluminum foil layer (4) / second adhesive layer (5) / sealant layer (6) Can do.

FIG. 2 is an explanatory view showing an example of the low adsorptive packaging material of the present invention. It is an external view which shows an example of the low adsorptive packaging material of this invention.

The low adsorptive packaging material (8) is provided with a reclose portion (7) to improve the sealing performance for multiple uses. The reclose portion (7) is a polyethylene chuck portion and is attached by heat-sealing with a sealant layer of a low-adsorbent packaging material. In the contents (9), a plurality of patches, cataplasms and the like are laminated via a release sheet, which is applied to the skin and absorbs medicinal components by percutaneous absorption.

Specific examples of the present invention will be described below.

(A base material layer (1), a first adhesive layer (2), a polyethylene layer (3), an aluminum foil layer (4), a second adhesive layer (5), and a sealant layer (6) are laminated in this order. In order to produce a low-adsorbent packaging material , the following materials were used.
Base material layer (1) : PET film 12μ, Toyobo Co., Ltd., E5100
First adhesive layer (2) : Mitsui Chemicals Polyurethanes, A-3210 (urethane resin) / A-3075 (aromatic tolylene diisocyanate / hexamethylene diisocyanate = 1/1), (solid content: 5% ), Dry coating amount 0.5 g / m ²
Polyethylene layer (3) : Nippon Polyethylene Corporation, LC600A, thickness 15 μm
Aluminum foil layer (4) : 9 μm, Toyo Aluminum Co., Ltd., 8021
Second adhesive layer (5) : Toyo Ink Manufacturing Co., Ltd., CAT-10 (aromatic tolylene diisocyanate)
(Solid content: 5%), dry coating amount 0.3 g / m ² , thickness 0.2 μm
Sealant layer (6) : Nippon Polyethylene Co., Ltd., LC600A, density 0.918 g / cm ³ , thickness 30 μm
Bonding was performed by extrusion lamination.

Hereinafter, comparative examples of the present invention will be described.

<Comparative Example 1>
(A base material layer (1), a first adhesive layer (2), a polyethylene layer (3), an aluminum foil layer (4), a second adhesive layer (5), and a sealant layer (6) are laminated in this order. The following materials were used in the same manner as in Example 1 to produce a low-adsorbent packaging material .
Base material layer (1) : PET film 12μ, Toyobo Co., Ltd., E5100
First adhesive layer (2) : Mitsui Chemicals Polyurethane Co., Ltd., A-3210 / A-3075, (solid content: 5%), dry coating amount 0.5 g / m ²
Polyethylene layer (3) : Nippon Polyethylene Corporation, LC600A, thickness 15 μm
Aluminum foil layer (4) : 9 μm, Toyo Aluminum Co., Ltd., 8021
Second adhesive layer (5) : Mitsui Chemicals Polyurethanes, A-3210 / A-3075, (solid content: 5%),
Dry coating amount 0.5g / m ² , thickness 0.35μm
Sealant layer (6) : Nippon Polyethylene Co., Ltd., LC600A, density 0.918 g / cm ³ , thickness 30 μm
Bonding was performed by extrusion lamination.

<Comparative example 2>
A configuration similar to that of Comparative Example 1 was created using the following materials.
Base material layer (1) : PET film 12μ, Toyobo Co., Ltd., E5100
First adhesive layer (2) : Mitsui Chemicals Polyurethanes, A-3210 / A-3075, (solid content: 5%),
Dry coating amount 0.5g / m ²
Polyethylene layer (3) : Nippon Polyethylene Corporation, LC600A, thickness 15 μm
Aluminum foil layer (4) : 9 μm, Toyo Aluminum Co., Ltd., 8021
Second adhesive layer (5) : Toyo Ink Manufacturing Co., Ltd., AD-502 (urethane resin) / CAT-10 (aromatic tolylene diisocyanate), (solid content: 5%), dry coating amount 0.8 g / M ² , thickness 0.7μm
Sealant layer (6) : Nippon Polyethylene Co., Ltd., LC600A, density 0.918 g / cm ³ , thickness 30 μm
Bonding was performed by extrusion lamination.

<Comparative Example 3>
A configuration similar to that of Comparative Example 1 was created using the following materials.
Base material layer (1) : PET film 12μ, Toyobo Co., Ltd., E5100
First adhesive layer (2) : Mitsui Chemicals Polyurethanes, A-3210 / A-3075, (solid content: 5%),
Dry coating amount 0.5g / m ²
Polyethylene layer (3) : Nippon Polyethylene Corporation, LC600A, thickness 15 μm
Aluminum foil layer (4) : 9 μm, Toyo Aluminum Co., Ltd., 8021
Second adhesive layer (5) : Toyo Ink Manufacturing Co., Ltd., AD-502 / CAT-10 (solid content: 5%),
Dry coating amount 0.8g / m ² , thickness 0.7μm
Sealant layer (6) : Nippon Polyethylene Corporation, LC600A, density 0.918 g / cm ³ , thickness 20 μm
Bonding was performed by extrusion lamination.

<Comparative example 4>
A configuration similar to that of Comparative Example 1 was created using the following materials.
Base material layer (1) : PET film 12μ, Toyobo Co., Ltd., E5100
First adhesive layer (2) : Mitsui Chemicals Polyurethanes, A-3210 / A-3075, (solid content: 5%),
Dry coating amount 0.5g / m ²
Polyethylene layer (3) : Nippon Polyethylene Corporation, LC600A, thickness 15 μm
Aluminum foil layer (4) : 9 μm, Toyo Aluminum Co., Ltd., 8021
Second adhesive layer (5) : Toyo Ink Manufacturing Co., Ltd., AD-502 / CAT-10 (solid content: 5%),
Dry coating amount 0.8g / m ² , thickness 0.7μm
Sealant layer (6) : Sumitomo Chemical Co., Ltd., L405, density 0.924 g / cm ³ , thickness 30 μm The lamination was performed by extrusion lamination.

Using the packaging materials prepared in Example 1 and Comparative Examples 1 to 4 above, a 110 mm x 155 mm three-sided bag was prepared, filled with 20 mg of Zeporus tape sold by Mikasa Pharmaceutical Co., Ltd., and heat sealed And hermetically packaged. The packed product is stored in an environment of 40 ° C. and 75% RH for 3 months, and the amount of flurbiprofen adsorbed on the packaging material is extracted with methanol and then calibrated by gas chromatography. The amount of adsorption from the initial value of the component Was measured.

The standard value is 10% or less at 40 ° C and 75% RH after 6 months (Japanese Pharmacy Law). Therefore, the target value is 5% after 3 months at 40 ° C and 75% RH. It was as follows.

実施例１の構成、即ち第２の接着層（５）として、芳香族型トリレンジイソシアネート一液で使用した構成が、フルルビプロフェンの吸着量が低い結果になった。日本薬局方において４０℃、７５％ＲＨ環境下、６ヶ月保存時に薬効成分の吸着量が１０％以下である基準あることから、比較例２、３、４は当該規格を外れているため使用できない。 <Comparison result>

The configuration of Example 1, that is, the configuration used as the second adhesive layer (5) with one aromatic tolylene diisocyanate solution resulted in a low adsorption amount of flurbiprofen. In the Japanese Pharmacopoeia, there is a standard that the amount of adsorbed medicinal components is 10% or less when stored for 6 months in an environment of 40 ° C. and 75% RH. Therefore, Comparative Examples 2, 3, and 4 cannot be used because they are out of the standard. .

The present invention can be used for outer packaging bags such as transdermal absorbents.

1: Base material layer
2: First adhesive layer
3: Polyethylene layer
4: Aluminum foil layer
5: Second adhesive layer
6: Sealant layer (polyethylene layer)
7: Reclose section (polyethylene chuck)
8: Low adsorptive packaging
9: Contents (patch)

Claims (2)

Housing a percutaneous absorption preparation containing flurbiprofen, said Flour adsorption amount from the initial value of the bi flurbiprofen is 40 ° C., splicing when 5% or less der Ru low adsorptivity after 3 months at 75% RH A method of manufacturing a packaging material,
The low adsorptive packaging material includes a base material layer (1), a first adhesive layer (2), a polyethylene layer (3), an aluminum foil layer (4), a second adhesive layer (5), and a polyolefin sealant layer. (6) It is the structure laminated | stacked in order, Moreover, the said 2nd contact bonding layer (5) is the thickness of 0.1 micrometer to 0.5 micrometer, and is 1 liquid aromatic tolylene diisocyanate And
A method for producing a low adsorptive packaging material, wherein the aluminum foil layer (4) and the sealant layer (6) are bonded together by an extrusion laminating method through the second adhesive layer (5).   The method for producing a low-adsorbent packaging material according to claim 1, further comprising a reclose function.

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