JP6018438B2 - Dripping aerosol products - Google Patents

Description

  The present invention relates to a dripping aerosol product. More specifically, the present invention relates to a dripping type aerosol product in which an aerosol composition containing a large amount of a liquefied gas is dropped into droplets.

  Usually, when liquefied gas such as liquefied petroleum gas or dimethyl ether used in aerosol products is discharged into the atmosphere, it instantly vaporizes and increases its volume. Therefore, the discharge form of the aerosol product containing the liquefied gas in a large amount of 30% by mass or more in the aerosol composition is a fine particle form, that is, a spray form.

  In Patent Document 1, an aerosol composition containing 30% by weight or more of a liquefied gas is used by using a nozzle having a specific inner diameter and length, and the dropping amount and the flow rate are set in a specific range, whereby the diameter is 0.00. An aerosol product that can be dropped with 1-10 mm droplets is disclosed.

Japanese Patent No. 4178293

  According to the aerosol product of Patent Document 1, the discharge is cooled by the heat of vaporization of the liquefied gas to form droplets, and a part of the liquefied gas is present in the droplet-like discharge without being vaporized. When it is dropped between the toes, an excellent cooling feeling can be obtained. However, since the amount of the liquefied gas that is vaporized before the ejected material adheres to the dropping surface is large, it is impossible to efficiently give the cooling feeling of the liquefied gas to the dropping surface. In addition, the vaporization of the liquefied gas on the dropping surface is fast, so that the cooling effect is difficult to sustain, and the drying of the droplets is fast, so it is difficult to visually check the amount used, and it is easy to use beyond the dose. is there.

  Therefore, the present invention is an aerosol product in which an aerosol composition containing a large amount of liquefied gas is dropped into droplets, and the liquefied gas is concentrated on the dropping surface by holding the liquefied gas long in the dropped droplet. It aims at providing the dripping type aerosol product which can confirm the dripping amount visually while being able to obtain the continuous cooling effect by vaporizing.

  The present invention is a dripping type aerosol product in which an aerosol composition comprising a stock solution and a liquefied gas is filled in an aerosol container equipped with an aerosol valve, and the aerosol composition is dropped into droplets, the stock solution comprising a polymer and It contains alcohol, the viscosity of the stock solution is 10 to 50,000 mPa · s, the liquefied gas contains a hydrophilic liquefied gas, and the content of the liquefied gas in the aerosol composition is 35 to 90% by mass. Further, the present invention relates to a dripping type aerosol product having a dripping amount of 1.3 to 5.0 g / 10 seconds.

  The polymer is preferably a cellulosic polymer.

  The hydrophilic liquefied gas is preferably dimethyl ether.

The aerosol valve includes a liquid passage for introducing a liquid of an aerosol composition and a gas passage for introducing a gas, and the relationship between the minimum cross-sectional area SL of the liquid passage and the minimum cross-sectional area SG of the gas passage is:
0.1 ≦ SG / SL ≦ 15
It is preferable to satisfy.

  According to the dripping type aerosol product of the present invention, the stock solution in the aerosol composition contains a polymer and alcohol, the viscosity of the stock solution is 10 to 50,000 mPa · s, and the content of the liquefied gas in the aerosol composition is The aerosol composition can be dropped into droplets by setting the amount to 35 to 90% by mass and the dropping amount to 1.3 to 5.0 g / 10 seconds, and the liquefied gas is added to the dropped droplets. A dripping type aerosol product that can be held for a long time and can provide a continuous cooling effect by concentrating vaporization of the liquefied gas on the dripping surface and visually confirming the dripping amount can be provided. .

  When the polymer is a cellulosic polymer, it can be easily dissolved in a stock solution containing alcohol, and the effect of suppressing the vaporization of the liquefied gas in the droplets is high, so the duration of the cooling effect can be further increased. can do.

  When the hydrophilic liquefied gas is dimethyl ether, since the polymer is easily dissolved, clogging by the polymer such as the discharge passage and the discharge hole can be prevented.

The aerosol valve includes a liquid passage for introducing a liquid of an aerosol composition and a gas passage for introducing a gas, and the relationship between the minimum cross-sectional area SL of the liquid passage and the minimum cross-sectional area SG of the gas passage is:
0.1 ≦ SG / SL ≦ 15
In the case of satisfying the above, it becomes a dripping amount that can be dropped in the form of droplets without providing a flow path control member in the passage or making the stem hole small, and clogging by the polymer can be further prevented.

It is sectional drawing which shows one Embodiment of an aerosol valve. It is a graph which shows the result of the cooling performance evaluation of a part of example and a comparative example.

  The dripping type aerosol product of the present invention is characterized in that an aerosol composition comprising a specific stock solution and a liquefied gas is filled in an aerosol container, and the dripping amount is 1.3 to 5.0 g / 10 seconds.

  The undiluted solution contains a polymer and alcohol and is adjusted to a specific viscosity to suppress vaporization of the liquefied gas after the aerosol composition is discharged (dropped) from the aerosol container until it reaches the dropping surface. As a result, the liquefied gas is intensively vaporized on the dropping surface, and a continuous cooling effect can be imparted to the dropping surface, and the dropping amount can be visually confirmed.

  The polymer adjusts the viscosity of the stock solution and suppresses vaporization when the aerosol composition is dropped, thereby maintaining the cooling effect on the dropping surface, making it easy to visually check the dropping amount, Contains for the purpose of preventing dripping. Moreover, when a dripping surface is an affected part on skin, it also has the objective of protecting an affected part.

  Examples of polymers include cellulose polymers such as methylcellulose, ethylcellulose, nitrocellulose, hydroxyethylcellulose, hydroxypropylcellulose, sodium carboxymethylcellulose; xanthan gum, carrageenan, gum arabic, tragacanth gum, cationized guar gum, guar gum, duran gum, locust bean gum, etc. Gum quality: polyurethane, collagen hydrolyzate, cationized hydrolyzed collagen, palm oil fatty acid hydrolyzed collagen, keratin, keratin hydrolyzate, cationized hydrolyzed keratin, casein, casein hydrolyzate, gelatin, gelatin hydrolyzate , Cyclodextrin, sodium carboxymethyldextrin, dextrin, pectin, starch, corn starch, wheat Npun, sodium alginates, modified potato starch, sodium hyaluronate, Polyvinyl alcohol, polyvinyl pyrrolidone, and the like carboxyvinyl polymer. Among these, a cellulose polymer is preferable because it has a high effect of suppressing vaporization of the liquefied gas in the droplet when the aerosol composition is dropped, and hydroxypropyl cellulose is particularly preferable because it is easily dissolved in a stock solution containing alcohol. Is more preferable.

  The content of the polymer is preferably 0.1 to 10% by mass in the stock solution, and more preferably 0.2 to 5% by mass. When the content of the polymer is less than 0.1% by mass, the viscosity of the stock solution is low and the effect of containing the polymer tends to be difficult to obtain. Moreover, when it exceeds 10 mass%, it tends to be clogged in the discharge passage or the like, and when it is dried on the dropping surface, it tends to be sticky and the feeling of use tends to deteriorate.

  The alcohol is contained as a solvent for the polymer and as a solvent for an active ingredient and other components described later. Moreover, it acts as a pressure adjusting agent that lowers the pressure of the aerosol composition to allow the drop to fall naturally.

  As alcohol, it is easy to dissolve with the liquefied gas described later, suppresses the vaporization of the liquefied gas in the dropped droplet, and has a high effect of cooling the affected part when attached to the affected part, and the vapor pressure at normal temperature. It is preferable to use a monohydric alcohol having 2 to 3 carbon atoms, such as ethanol and isopropanol.

  The alcohol content is preferably 10 to 99.5% by mass in the stock solution, more preferably 20 to 99.0% by mass. When the content of alcohol is less than 10% by mass, the effect of containing alcohol tends to be not obtained. Moreover, when it exceeds 99.5 mass%, there exists a tendency for it to become difficult to contain components other than alcohol.

  In addition to the polymer and alcohol, the stock solution may contain an active ingredient, water, a surfactant, an oil, a powder, and the like as necessary.

  Examples of the active ingredient include bactericidal and disinfecting agents such as paraoxybenzoic acid ester, chlorhexidine chloride, phenoxyethanol, benzalkonium chloride, benzethonium chloride; butenafine hydrochloride, terbinafine hydrochloride, oxyconazole nitrate, tolnaftate, miconazole nitrate, econazole nitrate, chlorate Antifungal agents such as trimazole; anti-inflammatory agents such as allantoin, glycyrrhetinic acid, dipotassium glycyrrhizinate; local anesthetics such as dibucaine hydrochloride, tetracaine hydrochloride, lidocaine hydrochloride, lidocaine; diphenhydramine, diphenhydramine hydrochloride, chlorpheniramine maleate, etc. Antihistamines of crotamiton, d-camphor, etc .; Anti-itch agents such as l-menthol, camphor, mint oil; Methyl salicylate, Indometha , Piroxicam, felbinac, ketoprofen and other anti-inflammatory analgesics; minoxidil, assembly extract, carpronium chloride, glyceryl pentadecanoate, isopropylphenol, dipotassium glycyrrhizinate, tocopherol acetate, red pepper tincture, seaweed extract, hypericum extract, etc .; propylene glycol, Moisturizers such as glycerin, 1,3-butylene glycol, collagen, hyaluronic acid, sodium lactate, urea; astringents such as zinc oxide, allantoin hydroxyaluminum, citric acid, lactic acid; retinol, dl-α-tocopherol, pantothenic acid, etc. Vitamins; deodorants such as lauric acid methacrylate, acetophenone myristate, tea extract; aluminum chlorohydrate, allantoin aluminum Antiperspirants such as muchlorohydrate and zinc oxide; pest repellents such as N, N-diethyl-m-toluamide (diet); paraaminobenzoic acid, octyl salicylate, isopropyl paramethoxycinnamate, paramethoxycinnamate UV absorbers such as octyl; antioxidants such as α-tocopherol, dibutylhydroxytoluene, tocopherol acetate; extracts such as eucalyptus extract, eucalyptus oil, sage extract, tea extract, seaweed extract, placenta extract; various flavors; Can be mentioned.

  When the active ingredient is contained, the content in the stock solution is preferably 0.01 to 20% by mass, and more preferably 0.05 to 10% by mass. When the content of the active ingredient is less than 0.01% by mass, the effect of the active ingredient tends to be difficult to obtain. Moreover, when it exceeds 20 mass%, depending on an active ingredient, a density | concentration becomes high too much and may have a bad influence. The active ingredient may be dissolved in a solvent, or it may be dissolved after adding a liquefied gas to an aerosol container filled with a stock solution to form an aerosol composition.

  The water is used for the purpose of suppressing vaporization of the dropped droplet and maintaining a cooling feeling.

  Examples of water include purified water, ion exchange water, and physiological saline.

  In the case of containing water, the content in the stock solution is preferably 1 to 80% by mass, and more preferably 3 to 70% by mass. When the water content is less than 1% by mass, the effect of containing water tends to be difficult to obtain. Moreover, when it exceeds 80 mass%, there is a tendency for the alcohol content to decrease and to become difficult to dissolve with a polymer or a hydrophilic liquefied gas. In addition, the cooling effect tends to decrease. Furthermore, the drying on the dropping surface is too slow and tends to sag.

  The surfactant is used for the purpose of adjusting the state of the droplet to be dropped, improving the feeling of use, and facilitating adhesion of the active ingredient to the dropping surface.

Examples of the surfactant include polyoxyethylene polyoxypropylene alkyl ethers such as POE · POP cetyl ether and POE · POP decyl tetradecyl ether; polyoxyethylene glycerin fatty acid esters such as POE glyceryl monostearate; POE lanolin alcohol and the like Polyoxyethylene lanolin alcohol; polyoxyethylene hydrogenated castor oil such as POE hydrogenated castor oil; POE cetyl ether, POE stearyl ether, POE oleyl ether, POE lauryl ether, POE behenyl ether, POE octyldodecyl ether, POE isocetyl ether, POE Polyoxyethylene alkyl ethers such as isostearyl ether; polyethylene such as polyethylene glycol monostearate Recall fatty acid ester, hexaglyceryl monolaurate, hexaglyceryl monomyristate, pentaglyceryl monolaurate, pentaglyceryl monomyristate, pentaglyceryl monooleate, pentaglyceryl monostearate, decaglyceryl monolaurate, decaglyceryl monomyristate, monostearin Polyglycerin fatty acid esters such as decaglyceryl acid, decaglyceryl monoisostearate, decaglyceryl monooleate, decaglyceryl monolinoleate; polyoxyethylene glycerin fatty acid esters such as POE glyceryl monooleate; monococonut oil fatty acid POE sorbitan, monopalmitin POE sorbitan monostearate, POE sorbitan monostearate, POE sorbitan monoisostearate Polyoxyethylene sorbitan fatty acid esters such as monooleate POE sorbitan; monolaurate POE sorbit, tetrastearate POE sorbit, polyoxyethylene sorbit fatty acid esters such as tetraoleate POE sorbitol; nonionic surfactants, and the like. Further, imidazoline-based amphoteric surfactants such as betaine acetate, imidazolium betaine, 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazoline sodium, lauryldimethylaminoacetic acid betaine, alkylbetaine, Amphoteric surfactants such as betaine amphoteric surfactants such as amide betaine and sulfobetaine;
Anionic surfactants such as fatty acid soaps, alkyl sulfates, polyoxyethylene alkyl ether sulfates, alkyl phosphates, polyoxyethylene alkyl ether phosphates, polyoxyethylene / methylpolysiloxane copolymers, poly Silicone surfactants such as oxypropylene / methylpolysiloxane copolymer and poly (oxyethylene / oxypropylene) / methylpolysiloxane copolymer, and natural systems such as surfactin sodium, cyclodextrin, and hydrogenated enzyme soybean lecithin Surfactant, N-coconut oil fatty acid acyl-L-glutamic acid triethanolamine, N-coconut oil fatty acid acyl-L-glutamic acid potassium, N-coconut oil fatty acid acyl-L-glutamic acid sodium, N-lauroyl-L-glutamic acid Triertanor N-, such as amines, potassium N-lauroyl-L-glutamate, sodium N-lauroyl-L-glutamate, potassium N-myristoyl-L-glutamate, sodium N-myristoyl-L-glutamate and sodium N-stearoyl-L-glutamate Acyl glutamate, N-coconut oil fatty acid acyl-L-glutamic acid, N-lauroyl-L-glutamic acid, N-stearoyl-L-glutamic acid and other N-acyl glutamic acid, N-coconut oil fatty acid acylglycine potassium, N-coconut oil Amino acid surfactants such as N-acylglycine salts such as fatty acid acylglycine sodium, N-acylalanine salts such as N-coconut oil fatty acid acyl-DL-alanine triethanolamine, and mixtures thereof.

  When the surfactant is contained, the content in the stock solution is preferably 0.01 to 10% by mass, and more preferably 0.05 to 5% by mass. When the content of the surfactant is less than 0.01% by mass, the effect of containing the surfactant tends to be difficult to obtain. Moreover, when it exceeds 10 mass%, surfactant tends to remain on the adhesion surface and the feeling of use tends to decrease.

  The oil is used for the purpose of improving the feeling of use, for example, to protect the skin by adding fat to the skin degreased with alcohol.

  Oils include diisopropyl adipate, isopropyl myristate, isopropyl palmitate, cetyl octanoate, octyldodecyl myristate, butyl stearate, myristyl myristate, decyl oleate, cetyl lactate, isocetyl stearate, cetostearyl alcohol, adipic acid Ester oils such as diisobutyl, diisopropyl sebacate, diethoxyethyl succinate, diisostearyl malate; methyl polysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, methylcyclopolysiloxane, tetrahydro Tetramethylcyclotetrasiloxane, octamethyltrisiloxane, decamethyltetrasiloxane, methylhydrogenpoly Silicone oils such as loxane and methylphenylpolysiloxane; fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, isostearic acid; lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, lanolin Higher alcohols such as alcohol, oils such as avocado oil, macadamia nut oil, shea fat, olive oil and camellia oil; waxes such as beeswax and lanolin wax; and the like.

  When the oil content is contained, the content in the stock solution is preferably 0.1 to 10% by mass, and more preferably 0.5 to 8% by mass. When the oil content is less than 0.1% by mass, the effect of containing the oil tends to be difficult to obtain. Moreover, when it exceeds 10 mass%, there exists a tendency for a sticky use feeling to fall on an adhesion surface.

  The powder is used for the purpose of the powder itself acting as an active ingredient, and for the purpose of acting as a carrier carrying other active ingredients, an adhesive, a protective agent for protecting the affected part, and the like.

  As powder, talc, zinc oxide, kaolin, mica, magnesium carbonate, calcium carbonate, zinc silicate, magnesium silicate, aluminum silicate, calcium silicate, silica, zeolite, ceramic powder, titanium oxide, magnesium stearate, Examples thereof include aluminum stearate and zinc stearate.

  In the case of containing powder, the content is preferably 0.01 to 5% by mass in the stock solution, and more preferably 0.03 to 3% by mass. When the content of the powder is less than 0.01% by mass, the effect of containing the powder tends to be difficult to obtain. If the powder content exceeds 5% by mass, it tends to be clogged with discharge holes, etc. When stored for a long period of time, the powder tends to harden at the bottom of the container (caking) and is uniform. There is a tendency that it is difficult to discharge a simple composition.

  The stock solution used in the present invention can be prepared by uniformly dissolving or dispersing a polymer in alcohol. Moreover, an active ingredient etc. can be dissolved and dissolved in alcohol as needed.

  The viscosity of the stock solution at 20 ° C. is 10 to 50,000 mPa · s, more preferably 50 to 45,000 mPa · s. When the viscosity of the undiluted solution is lower than 10 mPa · s, the amount of liquefied gas that is vaporized before the discharged material adheres to the dropping surface increases, and the cooling performance of the liquefied gas can be efficiently imparted to the dropping surface. There is a tendency not to. Moreover, when it becomes higher than 50,000 mPa · s, it tends to be difficult to handle, and it tends to be sticky and the feeling of use tends to decrease.

  The content of the stock solution is preferably 10 to 65% by mass, more preferably 15 to 60% by mass in the aerosol composition. When the content of the stock solution is less than 10% by mass, the vaporization of the droplets is accelerated and the cooling effect tends to be difficult to be sustained. On the other hand, if it exceeds 65% by mass, the vaporization and drying of the droplets are too slow, and it tends to sag.

  The liquefied gas is a liquid having a vapor pressure in the aerosol container and acts as a propellant. In addition, it is compatible with the stock solution to lower the viscosity of the aerosol composition and facilitate discharge. When discharged under atmospheric pressure, there is an effect that the discharged material can be cooled and cooled. Here, the liquefied gas of the present invention contains a hydrophilic liquefied gas. By containing the hydrophilic liquefied gas, it becomes easy to dissolve with the stock solution containing the polymer and alcohol, and it becomes easier to mix water in the stock solution, so that the cooling effect can be further maintained.

  Examples of the hydrophilic liquefied gas include dimethyl ether.

  The content of the hydrophilic liquefied gas is preferably 70% by mass or more, more preferably 80% by mass or more in the liquefied gas. When content of hydrophilic liquefied gas is less than 70 mass%, there exists a tendency for a cooling effect to fall and it becomes difficult to mix | blend water in stock solution.

  For the liquefied gas other than the hydrophilic liquefied gas, the cooling effect (cooling temperature, time) is adjusted by using the liquefied gas having different boiling points, which adjusts the pressure in the aerosol container to adjust the dropping amount and dropping state. It can be contained for the purpose.

  As the liquefied gas other than the hydrophilic liquefied gas, propane, normal butane, isobutane and liquefied petroleum gas which is a mixture thereof, trans-1,3,3,3-tetrafluoroprop-1-ene, trans-2,3 , 3,3-tetrafluoroprop-1-ene and the like, and lipophilic liquefied gases such as a mixture of the liquefied petroleum gas and the hydrofluoroolefin.

  In the case of containing a lipophilic liquefied gas, the content in the liquefied gas is preferably 30% by mass or less, and more preferably 20% by mass or less. When the content of the lipophilic liquefied gas exceeds 30% by mass, the polymer does not easily dissolve in the aerosol composition and tends to precipitate.

  The content of the liquefied gas is preferably 35 to 90% by mass, and more preferably 40 to 85% by mass in the aerosol composition. When the content of the liquefied gas is less than 35% by mass, there is a tendency that the effect of reducing the viscosity is low and it is difficult to discharge, the entire contents cannot be discharged, and the cooling performance is weakened. On the other hand, when it exceeds 90% by mass, the liquid droplets are rapidly vaporized and the cooling effect tends to be difficult to be sustained.

  The dripping type aerosol product of the present invention can be manufactured by filling an aerosol container body with a stock solution, then attaching an aerosol valve to the opening of the aerosol container body, and filling a liquefied gas from the aerosol valve stem. In addition, after filling the aerosol container body with the stock solution and then filling the liquefied gas with the undercup, the aerosol container body can also be manufactured by fixing and sealing the aerosol valve. Furthermore, in order to adjust the pressure in the aerosol container, a compressed gas such as carbon dioxide, nitrogen gas, compressed air, oxygen gas may be further filled as a pressurizing agent.

  The aerosol valve will be described with reference to FIG. 1 attached, but is not limited to this embodiment.

  The aerosol valve shown in FIG. 1 includes a mounting cap 2 fixed to an opening of an aerosol container main body (not shown) via a gasket 4, a housing 5 held at the center of the mounting cap 2, and an upper and lower portions inside the housing 5. Stem 1 accommodated movably, stem rubber 3 that opens and closes the stem hole of stem 1, spring 6 that constantly biases stem 1 upward and holds the stem hole at a position sealed by stem rubber 3 Consists of. The housing 5 has a lateral hole 51 that communicates with the inside of the aerosol container on the side surface, and a lower hole 52 that communicates with the interior of the aerosol container at the bottom, and a dip tube 7 is connected to the lower end of the housing 5. .

  Here, the dripping type aerosol product has an inverted specification in which the stem of the aerosol container is used with the stem downward and an upright specification in which the stem of the aerosol container is used with the stem upward.

  When the aerosol product is dropped by the inverted specification, the lateral hole 51 becomes a liquid passage for introducing the liquid of the aerosol composition into the housing 5, and the lower hole 52 becomes a gas passage for introducing the gas into the housing. Then, by pushing a discharge member (not shown) attached to the stem 1 of the aerosol valve, the stem is pushed, the stem rubber 3 is bent, the stem hole is opened, and the inside of the aerosol container communicates with the atmosphere. The liquid of the aerosol composition inside is introduced into the housing from the lateral hole 51 (liquid passage) of the housing, and further the gas of the aerosol composition enters the housing 5 from the lower hole 52 (gas passage) of the housing through the dip tube. Introduced, the liquid and gas are mixed and passed through the stem hole and dropped from the discharge member. That is, in the inverted specification, the liquid passage is passage A (arrow A in FIG. 1), and the gas passage is passage B (arrow B in FIG. 1).

  On the other hand, in the case of an upright specification dripping type aerosol product, the liquid of the aerosol composition is introduced into the housing 5 from the lower hole of the housing through the dip tube 7, and the gas of the aerosol composition is introduced into the housing 5 from the side hole. Is done. That is, in the case of the upright specification, the liquid passage is passage B (arrow B in FIG. 1), and the gas passage is passage A (arrow A in FIG. 1).

The aerosol valve of the present invention includes a liquid passage for introducing the liquid of the aerosol composition into the housing, and a gas passage for introducing the gas of the aerosol composition into the housing. The relationship with the minimum cross-sectional area SG of the passage is
0.1 ≦ SG / SL ≦ 15
It is preferable that
0.3 ≦ SG / SL ≦ 12
In particular, 1 ≦ SG / SL ≦ 10
In this case, it is possible to add a flow rate control member with fine holes in the discharge passage, or to reduce the amount of droplets without dropping the stem hole, and to prevent clogging by polymers It is preferable from the point which can be performed. Note that the relationship between the minimum cross-sectional area SL of the liquid passage and the minimum cross-sectional area SG of the gas passage is SG / SL <0.1.
In the case of, there is a tendency that it is discharged in a rod shape and cannot be dropped in a droplet shape,
15 <SG / SL
In this case, when the content decreases, the state of the droplet changes, and the content tends to be unable to be discharged to the end.

  Furthermore, the dripping type aerosol product of the present invention has a dripping amount of 1.3 to 5.0 g / 10 seconds, preferably 1.5 to 4.5 g / 10 seconds, and preferably 1.6 to 4. More preferably, it is 0 g / 10 seconds. When the dripping amount is less than 1.3 g / 10 seconds, the dripping amount is too small, the time from the discharge operation to the dropping becomes long, and it is easy to mistake if the user cannot drop. Moreover, since a droplet becomes small, there exists a tendency for a cooling effect to become difficult to be acquired at a dripping surface, and the tendency for the dripping amount to become difficult to visually check. Moreover, when it exceeds 5.0 g / 10 second, it does not become a droplet shape but tends to be ejected in a continuous state close to a rod shape.

  The dripping amount of the dripping type aerosol product can be adjusted by the ratio of the stock solution and the liquefied gas in the horizontal hole of the housing, the lower hole of the housing, the stem hole, and the aerosol composition.

  The dripping type aerosol product of the present invention has a continuous cooling effect by vaporizing liquefied gas intensively on the dripping surface, and since the dripping amount can be confirmed visually, athlete's foot drug, coolant, It is preferably applied to antipruritic agents, anti-inflammatory analgesics, astringents, hair restorers, burn treatments, itching prevention agents and the like.

  EXAMPLES Hereinafter, although an Example demonstrates this invention more concretely, this invention is not limited to these.

  The evaluation method is shown below.

<Viscosity of stock solution>
The stock solutions shown in Table 1 and Table 2 are placed in a cylindrical container and allowed to stand in an environment of 20 ° C. to adjust the liquid temperature to 20 ° C., and the viscosity is measured using a rotational viscometer (Model number: LV, manufactured by Brookfield). It was measured. The evaluation results are shown in Tables 1 and 2.

<Compatibility>
The aerosol product (using a transparent glass container) was stored at 25 ° C. and 5 ° C. for 1 month, and the presence of precipitates and turbidity was visually confirmed and evaluated according to the following criteria. The evaluation results are shown in Tables 1 and 2.
○: No precipitate or turbidity occurred at 25 ° C. and 5 ° C.
Δ: No precipitate or turbidity occurred at 25 ° C. Although it did not precipitate at 5 ° C., it was slightly turbid.
X: Precipitates were generated at 25 ° C and 5 ° C.

<Drip amount>
The aerosol product (using an aluminum container) was kept in a constant temperature water bath at 25 ° C. for 1 hour. Then, the aerosol composition was dripped continuously for 10 seconds, and the dripping amount was computed from the mass of the aerosol product for a test before and after dripping. The calculation results are shown in Tables 1 and 2.

<Drip state>
The aerosol product (using an aluminum container) was kept in a constant temperature water bath at 25 ° C. for 1 hour. Then, the aerosol composition was dripped, the state of the dripping material was confirmed visually, and the following criteria evaluated. The evaluation results are shown in Tables 1 and 2.
○: Droplet spontaneously dropped one by one.
Δ: Dropped in the form of droplets, but some were connected and discharged.
X1: It was close to rod-like jetting and did not become droplets.
X2: Vaporized before dropping and did not form droplets.
-: Not evaluated because the compatibility evaluation was x.

<Cooling performance>
The aerosol product (using an aluminum container) was kept in a constant temperature water bath at 25 ° C. for 1 hour. Thereafter, one drop was dropped on the back of the hand, and the temperature of the dropping surface was measured over time using thermography (FLIR i60, manufactured by FLIR Systems Japan Co., Ltd.). Moreover, the temperature which fell most from the temperature before dripping was read, and the following reference | standard evaluated. Tables 1 and 2 show the evaluation results of the temperature drop, and Table 3 shows the measurement results. Furthermore, the graph of the measurement result of Examples 1 and 11 and Comparative Examples 1 and 4 is shown in FIG.
○: The temperature drop was 16-30 ° C.
(Triangle | delta): The temperature fall was 12-15 degreeC.
X: The temperature drop was less than 11 ° C.
-: Not evaluated because the compatibility evaluation was x.

<Adhesiveness>
The aerosol product (using an aluminum container) was kept in a constant temperature water bath at 25 ° C. for 1 hour. Thereafter, when the aerosol composition was dropped onto the back of the hand, the adhesion of the droplet on the dropping surface was evaluated according to the following criteria. The evaluation results are shown in Tables 1 and 2.
(Double-circle): It adhered without dripping on the dropping surface, and did not dry for 200 seconds or more.
A: Adhered without dripping on the dropping surface and not dried for 150 to 199 seconds.
Δ: Drip did not drip on the dropping surface, but dried in less than 150 seconds.
X: The liquid dripped on the dropping surface.
-: Not evaluated because the compatibility evaluation was x.

<Discharge performance>
The aerosol product (using an aluminum container) was kept in a constant temperature water bath at 25 ° C. for 1 hour. Then, the aerosol composition was discharged, the state of the discharge (droplet), etc. was confirmed, and evaluated according to the following criteria. The evaluation results are shown in Tables 1 and 2.
◯: There was no change in the state of the droplets, and the entire amount could be discharged.
(Triangle | delta): Although the state of the droplet changed with the reduction | decrease of the content, it was able to discharge all quantity.
X: The state of the liquid droplet changed as the contents decreased, and the entire amount could not be discharged.
-: Not evaluated because the compatibility evaluation was x.

Examples 1-14, Comparative Examples 1-7
The aerosol composition consisting of the undiluted solution and liquefied gas shown in Table 1 is filled into a transparent glass aerosol container (full volume 100 ml) and an aluminum aerosol container (full volume 100 ml), and test aerosol products (inverted specification) ) Was prepared. Table 1 shows the minimum sectional area of the liquid passage A and the minimum sectional area of the gas passage B of the used aerosol valve. In Comparative Example 2, an aerosol valve having no gas passage was used. And <compatibility> was evaluated about the obtained aerosol product for test (product made from glass), and the remaining evaluation was performed about the aerosol product for test (product made from aluminum).

Formulation Example 1 athlete's foot drug 20 g of the following aqueous stock solution was filled in an aluminum aerosol container, an aerosol valve was attached, and 80 g of DME (* 2) was filled. Incidentally, the aerosol valve is 0.07 mm ² minimum cross-sectional area of the fluid path, the minimum cross-sectional area of the gas passage is used as a 0.28 mm ^2.

<Aqueous stock solution>
Purified water 10.0
Ethanol 82.5
Hydroxypropyl cellulose (* 1) 2.0
Propylene glycol 4.0
l-Menthol 0.5
Butenafine hydrochloride 1.0
Total (parts by mass) 100.0

Formulation Example 2 Coolant 30 g of the following aqueous stock solution was filled in an aluminum pressure vessel, a valve was attached, and 70 g of DME (* 2) was filled from the valve. Incidentally, the aerosol valve is 0.07 mm ² minimum cross-sectional area of the fluid path, the minimum cross-sectional area of the gas passage is used as a 0.28 mm ^2.

<Aqueous stock solution>
Ethanol 95.5
Hydroxypropyl cellulose (* 1) 1.0
Propylene glycol 3.0
l-Menthol 0.5
Total (parts by mass) 100.0

Formulation Example 3 Hair Growth Agent 40 g of the following aqueous stock solution was filled in an aluminum aerosol container, an aerosol valve was attached, and 60 g of DME (* 2) was filled. Incidentally, the aerosol valve is 0.07 mm ² minimum cross-sectional area of the fluid path, the minimum cross-sectional area of the gas passage is used as a 0.28 mm ^2.

<Aqueous stock solution>
Ethanol 96.8
Hydroxypropyl cellulose (* 1) 1.0
Glycerin 2.0
l-Menthol 0.1
dl-α-tocopherol 0.1
Total (parts by mass) 100.0

Formulation Example 4 Burn Burning Agent 20 g of the following aqueous stock solution was filled in an aluminum pressure-resistant container, a valve was attached, and 80 g of DME (* 2) was filled from the valve. Incidentally, the aerosol valve is 0.07 mm ² minimum cross-sectional area of the fluid path, the minimum cross-sectional area of the gas passage is used as a 0.28 mm ^2.

<Aqueous stock solution>
Water 5.0
Ethanol 89.7
Hydroxypropyl cellulose (* 1) 3.0
Propylene glycol 2.0
Lidocaine hydrochloride 0.3
Total (parts by mass) 100.0

  The above-mentioned evaluation was performed about the aerosol product obtained by the said prescription examples 1-4. The evaluation results are shown in Table 4.

1 Stem 2 Mounting Cap 3 Stem Rubber 4 Gasket 5 Housing 51 Horizontal Hole 52 Pilot Hole 6 Spring 7 Dip Tube A Passage A
B Passage B

Claims (4)

An aerosol composition comprising an undiluted solution and a liquefied gas is filled in an aerosol container equipped with an aerosol valve, and is a dripping type aerosol product in which the aerosol composition is dropped into droplets,
The stock solution contains a polymer and an alcohol;
The stock solution has a viscosity of 10 to 50,000 mPa · s,
The liquefied gas contains a hydrophilic liquefied gas;
The content of the liquefied gas in the aerosol composition is 40 to 90% by mass,
The polymer is a cellulosic polymer;
The blending amount of the alcohol is 50 to 99.5% by mass in the stock solution,
Ri amount of addition is 1.3~5.0g / 10 Byodea,
The aerosol valve includes a liquid passage for introducing a liquid of an aerosol composition and a gas passage for introducing a gas;
The relationship between the minimum cross-sectional area SL of the liquid passage and the minimum cross-sectional area SG of the gas passage is
0.1 ≦ SG / SL ≦ 15
A dripping aerosol product that meets the requirements . Dropwise aerosols product according to claim 1, wherein said hydrophilic liquefied gas is dimethyl ether. The content of the liquefied gas is 60 to 80% by mass,
The dripping type aerosol product according to claim 1 or 2, wherein the stock solution has a viscosity of 50 to 50,000 mPa · s. The relationship between the minimum cross-sectional area SL of the liquid passage and the minimum cross-sectional area SG of the gas passage is
0.3 ≦ SG / SL ≦ 10
The dripping type aerosol product of any one of Claims 1-3 which satisfy | fills.

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