JP6042436B2 - 二重活性Ｈ１インバースアゴニスト／５−ＨＴ２Ａアンタゴニストとしての（チエノ［２，３−ｂ］［１，５］ベンゾオキサゼピン−４−イル）ピペラジン−１−イル化合物 - Google Patents

二重活性Ｈ１インバースアゴニスト／５−ＨＴ２Ａアンタゴニストとしての（チエノ［２，３−ｂ］［１，５］ベンゾオキサゼピン−４−イル）ピペラジン−１−イル化合物 Download PDF

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Publication number: JP6042436B2
Authority: JP; Japan
Prior art keywords: sleep; insomnia; pharmaceutically acceptable; compound; compounds
Prior art date: 2011-08-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

JP2014528453A

Other languages

English (en)

Japanese (ja)

Other versions

JP2014525440A (ja

Inventor

レッドガード，アンドリュー，ジェームズ

Original Assignee

イーライリリーアンドカンパニー

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-08-30

Filing date

2012-08-22

Publication date

2016-12-14

2012-08-22 Application filed by イーライリリーアンドカンパニー, イーライリリーアンドカンパニー filed Critical イーライリリーアンドカンパニー

2014-09-29 Publication of JP2014525440A publication Critical patent/JP2014525440A/ja

2016-12-14 Application granted granted Critical

2016-12-14 Publication of JP6042436B2 publication Critical patent/JP6042436B2/ja

Status Expired - Fee Related legal-status Critical Current

2032-08-22 Anticipated expiration legal-status Critical

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Classifications

- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

JP2014528453A 2011-08-30 2012-08-22 二重活性Ｈ１インバースアゴニスト／５−ＨＴ２Ａアンタゴニストとしての（チエノ［２，３−ｂ］［１，５］ベンゾオキサゼピン−４−イル）ピペラジン−１−イル化合物 Expired - Fee Related JP6042436B2 (ja)

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US61/528,893		2011-08-30
PCT/US2012/051833 WO2013032804A1 (en)	2011-08-30	2012-08-22	(THIENO[2,3-b][1,5]BENZOXAZEPIN-4-YL)PIPERAZIN-1-YL COMPOUNDS AS DUAL ACTIVITY H1 INVERSE AGONISTS/5-HT2A ANTAGONISTS

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US (1)	US9512140B2 (sr)
EP (1)	EP2751115B1 (sr)
JP (1)	JP6042436B2 (sr)
KR (1)	KR101596607B1 (sr)
CN (1)	CN103958523B (sr)
AU (1)	AU2012300451B2 (sr)
BR (1)	BR112014004557A2 (sr)
CA (1)	CA2843514C (sr)
DK (1)	DK2751115T3 (sr)
EA (1)	EA024248B1 (sr)
ES (1)	ES2650225T3 (sr)
HR (1)	HRP20171824T1 (sr)
HU (1)	HUE034845T2 (sr)
LT (1)	LT2751115T (sr)
MX (1)	MX350419B (sr)
NO (1)	NO2776955T3 (sr)
PL (1)	PL2751115T3 (sr)
PT (1)	PT2751115T (sr)
RS (1)	RS56537B1 (sr)
SI (1)	SI2751115T1 (sr)
WO (1)	WO2013032804A1 (sr)
ZA (1)	ZA201400874B (sr)

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AU2012283035B2 (en) *	2011-07-08	2015-07-30	Eli Lilly & Company	(thieno[2,3-b][1,5]benzoxazepin-4-yl)piperazin-1-yl compounds as dual activity H1 inverse agonists/5-HT2A antagonists
LT2943498T (lt) *	2013-01-14	2017-11-27	Eli Lilly And Company	(tieno[2,3-b][1,5]benzoksazepin-4-il)piperazin-1-ilo junginiai kaip dvigubo aktyvumo h1 inversiniai agonistai / 5-ht2a antagonistai
TW201625644A (zh)	2014-04-29	2016-07-16	美國禮來大藥廠	作為選擇性５－ＨＴＡ反向促效劑之（噻吩并［２，３－ｂ］［１，５］苯并氧氮呯－４－基）哌嗪－１－基化合物
WO2018177993A1 (de)	2017-03-31	2018-10-04	Bayer Cropscience Aktiengesellschaft	Pyrazole zur bekämpfung von arthropoden
WO2018234488A1 (en)	2017-06-23	2018-12-27	Basf Se	Substituted cyclopropyl derivatives
WO2019185413A1 (en)	2018-03-27	2019-10-03	Basf Se	Pesticidal substituted cyclopropyl derivatives
JP7644009B2 (ja) *	2018-12-21	2025-03-11	オゲダエス．エー．	３－メチル－１，２，４－チアジアゾール－５－カルボヒドラジドまたはそのメチル－ｄ３重水素化形態の合成
JP7696354B2 (ja) *	2019-10-21	2025-06-20	アライリオンインコーポレイテッド	睡眠障害の治療のためのＨ１および５－ＨＴ２Ａ受容体調節物質としての３－（４－（１１Ｈ－ジベンゾ［ｂ，ｅ］［１，４］アゼピン－６－イル）ピペラジン－１－イル）－プロパン酸誘導体および３－（４－（ジベンゾ［ｂ，ｆ］［１，４］オキサゼピン／チアゼピン／ジアゼピン－１１－イル）ピペラジン－１－イル）－プロパン酸誘導体
AU2022219182A1 (en)	2021-02-11	2023-08-24	Basf Se	Substituted isoxazoline derivatives
EP4043444A1 (en)	2021-02-11	2022-08-17	Basf Se	Substituted isoxazoline derivatives
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Also Published As

Publication number	Publication date
ZA201400874B (en)	2015-10-28
PT2751115T (pt)	2017-12-20
PL2751115T3 (pl)	2018-02-28
BR112014004557A2 (pt)	2017-05-30
HUE034845T2 (en)	2018-03-28
MX2014002473A (es)	2016-09-26
US9512140B2 (en)	2016-12-06
SI2751115T1 (sl)	2017-11-30
JP2014525440A (ja)	2014-09-29
AU2012300451B2 (en)	2016-10-13
ES2650225T3 (es)	2018-01-17
HRP20171824T1 (hr)	2017-12-29
US20140171411A1 (en)	2014-06-19
EP2751115B1 (en)	2017-09-20
KR101596607B1 (ko)	2016-02-22
WO2013032804A1 (en)	2013-03-07
EA024248B1 (ru)	2016-08-31
DK2751115T3 (en)	2017-10-23
CN103958523B (zh)	2016-07-27
EA201490332A1 (ru)	2014-06-30
CN103958523A (zh)	2014-07-30
MX350419B (es)	2017-09-05
EP2751115A1 (en)	2014-07-09
LT2751115T (lt)	2017-12-27
NO2776955T3 (sr)	2018-06-02
CA2843514C (en)	2017-01-10
KR20140051355A (ko)	2014-04-30
RS56537B1 (sr)	2018-02-28
CA2843514A1 (en)	2013-03-07
AU2012300451A1 (en)	2014-01-30

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JP6042436B2 (ja)	2016-12-14	二重活性Ｈ１インバースアゴニスト／５−ＨＴ２Ａアンタゴニストとしての（チエノ［２，３−ｂ］［１，５］ベンゾオキサゼピン−４−イル）ピペラジン−１−イル化合物
JP6050813B2 (ja)	2016-12-21	二重作用Ｈ１インバースアゴニスト／５−ＨＴ２Ａアンタゴニストとしての（チエノ［２，３−ｂ］［１，５］ベンゾオキサゼピン−４−イル）ピペラジン−１−イル化合物
JP6100400B2 (ja)	2017-03-22	二重活性Ｈ１インバースアゴニスト／５−ＨＴ２Ａアンタゴニストとしての（チエノ［２，３−ｂ］［１，５］ベンゾオキサゼピン−４−イル）ピペラジン−１−イル化合物