JP6074701B2 - Biohealing ability improvement device for high altitude environment - Google Patents

Description

  The present invention relates to a device for improving a living body healing power that uses reduced pressure of air and pressurized pressure to normal pressure.

  The present inventor has proposed an optimum pressure regulating device and pressure regulating method for performing an air bath using stimulation due to a temperature difference (see Patent Document 1). Furthermore, a pressure reducing step from the normal pressure state to the reduced pressure state equal to or higher than the threshold pressure by the pressure regulator, and a pressure applying step from the reduced pressure state to the normal pressure or a broad normal pressure state that is higher than the reduced pressure state and lower than the normal pressure, The human healing ability improvement device is confirmed by confirming the action of the human body healing power effect to return abnormal body tissues, body organs, etc. to healthy body tissues, body organs by continuous and continuous stimulation. Proposed (see Patent Document 2).

Japanese Patent No. 4477690 International Publication No. 2011-065319

  In the above-mentioned living body healing ability, it is preferable to disclose a mode in which a stimulus that improves the natural healing power of the living body is favorably provided by increasing the pressure change per unit time of the pressurizing process as compared with the decompression process. Has been. However, when the pressure change per unit time in the pressurizing process is increased, the pressure is suddenly changed from the reduced pressure state to the normal pressure state or to the wide normal pressure state that is higher than the reduced pressure state and lower than the normal pressure. The difference in atmospheric pressure from the ear became significant, and it was sometimes necessary to remove the ear.

  However, if the eustachian tube is closed due to a cold or the like, the ear can not be satisfactorily removed, and if it is severe, ear pain, foreign object sensation, and discomfort may occur. Therefore, conversely, in order not to perform the ear removal as much as possible, the pressure change per unit time in the decompression process has been increased compared to the pressurization process. In this case, the stimulus that improves the natural healing power of the living body must receive more stimuli than the case where the pressure change per unit time in the pressurizing process is increased, but the advantage of reducing the burden of ear removal There is.

  The eustachian tube has a structure in which it is easy to remove air from the middle ear and it is difficult for air to enter the middle ear. Although the atmospheric pressure difference that requires ear removal depends on individual differences, it may occur even when the altitude difference of several hundred meters rises or falls within a short time.

  On the other hand, in the above-described living body healing ability improving device, the pressurizing step is performed at normal pressure in order to alternately repeat the decompression step of decompressing the inside of the hermetic portion with a decompression pump and the pressurizing step of pressurizing by communicating with the outside air. It is intended to be installed in plain areas with altitudes ranging from 0m to 200m. Various types of decompression pumps are used, but in any case, there is a problem that the valve mechanism for maintaining the suction state is liable to fail and the maintenance cost is not stupid.

  As a place for installing the living body healing ability improving device, a highland is assumed in addition to the plain. For example, in a high altitude environment such as Mexico City at an altitude of 2200 m and Karuizawa at an altitude of 1000 m, the airtight part of the biohealing ability improving device is set to a normal pressure (1013 hPa) or a wide range of normal pressure at an altitude of 200 m (989 hPa) in the pressurizing process. For this purpose, a pressurizing device is preferably provided in addition to the vacuum pump.

  By the way, as a result of diligent efforts, the present inventors set the pressure reduction state to be changed in the pressure reduction process to a pressure corresponding to an altitude of 100 m or higher, a conventional pressure reduction state of 2000 m, and a (wide) normal pressure state. By maintaining the pressure change per unit time of the decompression step and the pressurization step, the effect of which was obtained when continuous repetition of the above was confirmed, the effect of increasing body temperature as part of the body healing effect was confirmed, and the present invention It came to.

  That is, the present invention obtains a biohealing power effect that attempts to return abnormal body tissue, body organ, etc. to healthy body tissue, body organ without generating a pressure difference that is large enough to remove ears. An object of the present invention is to obtain a high-health environment biohealing ability improvement device with a simple configuration when the installation location is a high-altitude environment.

The biological healing ability improvement device for high altitude environment according to the invention described in claim 1 is configured such that the air pressure in the airtight portion that can be airtight is a reduced pressure state equal to or higher than a predetermined threshold pressure, and a wide normal pressure state of 1013 hPa to 1000 hPa. An apparatus for improving the healing ability of a living body that repeats continuously without pausing,
Said airtight unit, a pressurization means for pressurizing the air pressure in the airtight portion from said reduced pressure condition to a wide range normal pressure of the 1013HPa～1000hPa, pressure reducing means for reducing the pressure to the reduced pressure state from a wide normal pressure of the 1013HPa～1000hPa And a body healing ability improving device comprising a reduced pressure control means for controlling the pressurizing means and the pressure reducing means to continuously repeat a reduced pressure state and a wide normal pressure state of 1013 hPa to 1000 hPa .
The installation atmosphere of the device is an atmospheric pressure corresponding to an altitude of an altitude of 400 m to an altitude of 1000 m,
As the depressurization means, a communication path for depressurizing to the atmospheric pressure of the installation atmosphere by communicating the inside and outside of the hermetic part in a depressurization step of depressurization from the wide normal pressure state of 1013 hPa to 1000 hPa to the depressurization state,
As the pressurizing means, an air supply path for supplying compressed air into an airtight part in a pressurizing step of pressurizing from the reduced pressure state to the wide normal pressure state of 1013 hPa to 1000 hPa ,
The reduced pressure control means controls the communication state of the communication passage and the air supply passage while measuring the pressure inside the airtight portion, and reduces the pressure inside the airtight portion to a reduced pressure state equal to or higher than the threshold pressure. It repeats continuously without pausing between a wide range of normal pressures of 1013 hPa to 1000 hPa, and it switches to the pressurizing step before the reduced pressure state is completely returned to the atmospheric pressure of the installation atmosphere. Yes,
The pressure change per unit time in the depressurization step and the pressurization step during continuous repetition of the depressurized state and the wide range normal pressure state of 1013 hPa to 1000 hPa is 19 hPa / min to 70 hPa / min To do.

  The present invention can obtain a body healing power effect that attempts to return abnormal body tissues, body organs, etc. to healthy body tissues, body organs without generating a pressure difference that is large enough to remove ears. In addition, when the installation location is a high-altitude environment, there is an effect of obtaining an inexpensive high-health environment biohealing ability improving device with a simple configuration.

It is a diagram which shows typically the atmospheric pressure change in an airtight part in a living body healing ability improvement device, and a vertical axis shows atmospheric pressure (hPa) and a horizontal axis shows time (min). It is a diagram which shows the change of the oxygen utilization rate in the expiration | expired_air at the time of controlling a pressure reduction process and a pressurization process repeatedly continuously. It is explanatory drawing explaining the state of the blood vessel of normal pressure and pressure reduction. It is the diagram which verified the effect of the living body healing capability improvement apparatus, and a vertical axis | shaft shows atmospheric pressure (hPa) and temperature (degreeC), and a horizontal axis shows time (min). It is the diagram which verified the effect of the living body healing capability improvement apparatus, and a vertical axis | shaft shows atmospheric pressure (hPa) and temperature (degreeC), and a horizontal axis shows time (min). It is the diagram which verified the effect of the living body healing capability improvement apparatus, and a vertical axis | shaft shows atmospheric pressure (hPa) and temperature (degreeC), and a horizontal axis shows time (min). It is explanatory drawing which shows the structure of one Example of the biohealing capability improvement apparatus for highland environments of this invention. FIG. 8 is a flowchart showing driving of the high altitude environment living body healing ability improving apparatus of FIG. 7, wherein FIG. A is a flowchart showing a depressurization step, and FIG. It is a diagram which shows typically the atmospheric | air pressure change in an airtight part in the biohealing capability improvement apparatus for highland environments of FIG. 7, A vertical axis | shaft shows considerable altitude (m) and a horizontal axis shows time (min).

  In the case of continuously changing between a reduced pressure state at an altitude of 2000 m or more (about 780 hPa or less) and a normal pressure state (1013 hPa) or a broad normal pressure state (1013 hPa to 1000 hPa) by the proposal of the aforementioned Patent Document 2 and the like. Has been confirmed to increase body temperature as part of the body healing effect. However, with this atmospheric pressure difference, even a healthy person needs ear removal, and in a sick person who has difficulty catching ears by pulling a cold or the like, ear removal is insufficient, and this pressure difference may cause pain.

  For subjects who are difficult to remove ears, the pressure change per unit time from the reduced pressure state to the (wide) normal pressure state is slower than the pressure change per unit time from the (wide) normal pressure state to the reduced pressure state. The inventor of the present invention has been made by the present inventor. However, the depressurization step to a reduced pressure state at an altitude of 2000 m or more (about 780 hPa or less) and the pressurization step from this depressurized state to a (broad) normal pressure state are continuously performed. Repeats were a burden for subjects who had difficulty with ear removal.

  Therefore, in the present invention, the atmospheric pressure in the hermetic part that can be hermetically sealed is a reduced pressure state that is equal to or higher than a predetermined threshold atmospheric pressure, and a normal pressure or a broad normal pressure state that is lower than the normal pressure and higher than the reduced pressure state. An apparatus for improving the ability to heal a living body that repeats continuously without pausing, an airtight part, a pressurizing means for pressurizing the air pressure in the airtight part from the reduced pressure state to a wide normal pressure state, and a wide normal pressure state A pressure reducing means for reducing pressure to a reduced pressure state, and a pressure reducing means for controlling the pressurizing means and the pressure reducing means to continuously repeat the pressure reducing state and the wide normal pressure state. It is a pressure corresponding to altitude, and is a communication path that connects the inside and outside of the hermetic part in the decompression process in which the decompression means decompresses from the wide normal pressure state to the decompression state, and the pressurization means changes from the decompression state to the wide normal pressure state. Airtight part in pressurizing process to pressurize A compressed air supply means for supplying compressed air to the. This makes it possible to obtain a body healing effect that attempts to return abnormal body tissues and body organs to healthy body tissues and body organs without generating a pressure difference that is large enough to remove the ears. Thus, a living body healing ability improving device can be obtained at low cost.

  That is, the living body healing ability improving apparatus of the present invention pauses between a reduced pressure state equal to or higher than a predetermined threshold pressure and a normal pressure or a broad normal pressure state lower than the normal pressure and higher than the reduced pressure state. Assuming that the installation place of the biohealing ability improving device that repeats continuously without being in a high altitude environment, the reduced pressure state is the atmospheric pressure of the installation place, and in the airtight part as a pressurizing means for obtaining a wide normal pressure state Compressed air supply means for supplying compressed air is provided.

  In this case, the airtight part that can be airtight is only required to be able to withstand the differential pressure between the decompressed state and the wide normal pressure state, which is the atmosphere of the high altitude environment. Specifically, in the atmosphere with an altitude of 400 m, the pressure is about 965 hPa, and any pressure that can withstand a differential pressure of about 50 hPa with respect to 1013 hPa, which is normal pressure at an altitude of 0 m, is used. In the famous Karuizawa and Mexico City at an altitude of 2200m, the atmospheric pressure is about 900 hPa and about 790 hPa, so any one that can withstand the differential pressure of about 100 hPa and about 220 hPa, which is the differential pressure from normal pressure, is acceptable. .

  As an airtight part of the present invention, the internal atmospheric pressure is paused between a reduced pressure state equal to or higher than a predetermined threshold pressure and a normal pressure or a broad normal pressure state lower than this normal pressure and higher than the reduced pressure state. What is necessary is just to provide the airtight part which can endure repeating continuously without. The material constituting the hermetic portion may be any material that maintains airtightness and can withstand the pressure change between the reduced pressure state and the wide range normal pressure state, and is made of metal, resin, wood or the like alone or in combination. The In particular, since the air pressure in the airtight portion does not become lower than the external air pressure in the high altitude environment where the airtight portion is installed, a structure that resists the expansion pressure from the inside is sufficient.

  For this reason, for example, as long as the airtightness of the joint portion such as a metal tank can be secured, a rectangular panel may be combined to form a hexahedron-like casing, and there is confidentiality. It is also possible to form a capsule using fiber reinforced plastic (FRP), gas barrier cloth, fabric, rubber sheet or the like.

  In addition, by increasing the air pressure in capsules that are already on the market, the amount of oxygen dissolved in the blood is increased to relieve fatigue and alleviate symptoms of sickness and altitude sickness. A portable pressurization device (Portable Altitude Chamber) can also be applied by providing a reduced pressure control means or the like that continuously repeats a reduced pressure state and a wide normal pressure state in a short time. For this reason, a living body healing ability improvement apparatus can be obtained cheaply.

  Furthermore, when the installation location is a high altitude environment, a drive system as a pressure reducing means is not required, and the pressure applying means can be easily supplied by supplying compressed air into the airtight portion, and maintenance is also possible. It is easy to obtain a biological healing ability improving device that is inexpensive to maintain.

  In the present invention, the reduced pressure state changed in the reduced pressure step is set to an atmospheric pressure corresponding to an altitude of 400 m or higher, and the conventional reduced pressure state at an altitude of 2000 m and the (wide) normal pressure state are continuously repeated. By maintaining the pressure change per unit time in the decompression step and the pressurization step in which the effect was obtained, the effect of increasing body temperature as part of the living body healing effect was confirmed, and the present invention was achieved. This will be described in detail.

FIG. 1 is a diagram schematically showing a change in atmospheric pressure in an airtight part of the living body healing ability improving device, wherein the vertical axis indicates atmospheric pressure (hPa) and the horizontal axis indicates time (min). As shown in the figure, the atmospheric pressure change (1000 hPa) indicated by the broken line and the reduced pressure state (about 670 hPa) at an altitude of about 3300 m, which is the same as the altitude of Mt. Fuji, are continuously changed twice in 50 minutes, An atmospheric pressure state (1000 hPa) indicated by a one-dot chain line and a reduced pressure state (about 845 hPa) at an altitude of 1500 m continuously repeated four times in 50 minutes, and an atmospheric pressure state (1000 hPa) indicated by a solid line The pressure change at an altitude of 900 m (about 910 hPa) is repeated eight times continuously in 50 minutes, the atmospheric pressure state indicated by a double line (1000 hPa), and the pressure reduction state at an altitude of 400 m (about 965 hPa). 4 types of atmospheric pressure changes are described, including an atmospheric pressure change that is repeated 16 times in 50 minutes.

  Although these four types of atmospheric pressure changes, since the pressure changes per unit time in the decompression step and the pressurization step are the same in these four types, the distances of the broken lines are equal. In the present invention, the pressure change per unit time of the decompression step and the pressurization step in which the effect of increasing body temperature has been confirmed, and by shortening the time of the decompression step and the pressurization step, and repeating these, The same or higher body temperature increasing effect was confirmed. This makes it possible not only to perform a large decompression process / pressurization process, but also to achieve a similar effect by repeatedly repeating a small decompression process / pressurization process, as well as a large atmospheric pressure difference to perform ear removal. Thus, it is not necessary to expose the subject to the above, and it is possible to obtain a biological healing effect that attempts to return abnormal body tissues, body organs, and the like to healthy body tissues, body organs.

  The “pressure change per unit time” in the present invention is indicated by, for example, a slope in a graph in which the vertical axis represents pressure and the horizontal axis represents time. Therefore, for example, in a decompression stroke in which the altitude is increased from 0 m (1013 hPa) to 2000 m (795 hPa) in 9 minutes, the pressure is 24.22 hPa / min (≈ (1013-795) / 9). Similarly, in the pressurizing process in which the altitude is lowered from 2000 m (795 hPa) to 0 m (1013 hPa) in 9 minutes, −24.22 hPa / min (≈ (795-1013) / 9) is obtained.

  In the present invention, the preferable pressure change per unit time in the decompression step and the pressurization step is ± 19 hPa / min or more. This is because the pressure change per unit time has been confirmed to be effective in the decompression step and the pressurization step. In the case where the pressure change per unit time is ± 19 hPa / min or more, the body temperature increasing effect as a part of the living body healing effect has been confirmed this time. The pressure change per unit time of ± 19 hPa / min or more corresponds to a pressure reducing / pressurizing process in which a height difference of about 158 m is moved per minute.

  As the minimum pressure of the decompression process in the present invention, that is, the altitude of the installation atmosphere of the biohealing ability improving device, the effect of raising the body temperature as part of the biohealing effect has been confirmed this time at the atmospheric pressure corresponding to the altitude of 100 m. However, the altitude is preferably 400 m (about 965 hPa) or higher, more preferably 600 m (943.2 hPa) or higher, from the individual difference, individual difference, change in weather conditions, pressure reduction / pressurization response, and the like. Even if it is continuously changed between the reduced pressure state of about 600 m (943.2 hPa) and the normal pressure state (1013 hPa) or the wide normal pressure state (1013 hPa to 1000 hPa), the same degree can be obtained even in a subject who has difficulty in ear removal. The effect is obtained.

  The “biological healing ability” referred to in the present invention refers to a force for returning an abnormal state to a healthy state by a recovery function inherent to the living body itself. That is, it restores and restores abnormal environments such as body fluid components such as blood, blood pressure, repair of damage to body tissues, and elimination of foreign substances (non-self) such as pathogenic microorganisms and viruses to a stable state. .

  More specifically, it refers to a function of trying to cure a disease such as a disorder of various functions of the body or an abnormal state that is not healthy to a normal state. Therefore, “improving the healing power of the living body” means improving the natural healing power itself, the speed of the reaction to quickly recognize that it is in an abnormal state, and the response to return to the normal state It also includes further improving the speed and the like.

  For example, reduction and disappearance of tumor cells that are not healthy cells, improvement of immune system hypersensitivity such as rheumatism, improvement of osteoporosis that is not healthy bone tissue, improvement of abnormal sugar metabolism, etc. In addition, although there is no specific data in the examples described later, by improving abnormal blood pressure, dissolving thrombus, preventing angina / cerebral thrombus / intracerebral hemorrhage by dissolving thrombus, improving cerebral blood flow Improvement of dementia is considered to be included.

  The change in the atmospheric pressure cycle of the present invention stimulates the subject in the hermetic zone and improves the natural healing power (biological homeostasis maintenance mechanism) of the subject. More specifically, it seems to improve the responsiveness of the work to return a disease such as a disorder of various functions of the body or an abnormal state of unhealthy state to a normal state.

  The reduced pressure control means in the present invention may be any means that continuously and repeatedly controls the atmospheric pressure cycle that changes between the reduced pressure state in the installation atmosphere of the apparatus and the wide range normal pressure state by the pressurizing means. The reduced pressure state refers to a pressure state that is equal to or close to the atmospheric pressure in the installation atmosphere by communicating the inside of the hermetic portion of the apparatus and the outside as the installation atmosphere through a communication path.

  On the other hand, the wide normal pressure state means that the inside of the hermetic portion is normal pressure (1013 hPa) or lower than the normal pressure and higher than the reduced pressure state by the pressurizing means. For example, as an installation atmosphere of the apparatus, a pressure change between an atmospheric pressure reduced state in which an apparatus having an altitude of 400 m or more, more preferably an altitude of 600 m or more, and normal pressure (1013 hPa) is continuously repeated. More preferably, the installation atmosphere of the apparatus is set to an atmospheric pressure of an altitude of 1000 m or less, the wide normal pressure state is set to an atmospheric pressure of an altitude of 50 m, and the pressure change between the reduced pressure state and the wide normal pressure state or the normal pressure state is repeated.

  Note that the reduced pressure state or the wide range normal pressure state that is continuously repeated may not be the same atmospheric pressure. For example, when the installation location of the apparatus is 1000 m altitude, the first wide normal pressure state is 1013 hPa corresponding to an altitude of 0 m, and the subsequent reduced pressure state is 965 hPa corresponding to an altitude of 600 m before being completely returned to the atmospheric pressure of the installation atmosphere. At this point, the pressurizing means may be driven to move to the pressurizing step. Similarly, the wide atmospheric pressure state that is repeated may be a different atmospheric pressure state such as normal pressure (1013 hPa) or 1001.2 hPa corresponding to an altitude of 100 m.

  In addition, although the airtight part in this invention is not assumed when it pressurizes positively more than a normal pressure (atmospheric pressure), the pressurization of the grade slightly over a normal pressure is naturally possible as an error range. For example, in the pressurizing step, when the atmospheric pressure is increased beyond normal pressure (1013 hPa), whether the living body healing ability is improved has not been specifically verified. It is known that about 10 hPa increases every 100 m above sea level. In fact, it is about 400 m above sea level in the Dead Sea coastal area, and considering that it is about 1050 hPa, it exceeds normal pressure at an altitude of 0 m, for example, 1050 hPa. In view of this, even if the reduced pressure state and the normal pressure state are repeated, it is considered that the biological healing ability is not significantly reduced.

  The pressure change per unit from the reduced pressure state in the airtight part to the wide normal pressure state, or from the wide normal pressure state to the reduced pressure state, that is, the speed of the pressure change gives a stimulus that improves the natural healing effect of the subject. If it is good. It was 19 hPa / min to 70 hPa / min, and the lowest atmospheric pressure in the depressurizing step was an atmospheric pressure corresponding to an altitude equivalent to an altitude of 100 m or higher, and a body temperature increasing effect as a part of the living body healing effect was confirmed.

  It has been verified in Examples described later that the stimulation of the continuous atmospheric pressure change between the reduced pressure state and the (wide) normal pressure state improves the natural healing power effect of the subject. Hypothesis 1 described later , 2 can be considered.

  Note that the compressed air supply means, which is the size of the hermetic portion and the pressurizing means, can bring about a sudden change in pressure reduction, so long as the pressure change between the reduced pressure state and the wide normal pressure state can be performed quickly. Good. Specific examples include an air supply pump, an air supply pump provided with a pressure adjusting tank, and a cylinder filled with compressed air. In the airtight portion having a large capacity, it is sufficient to provide one or more supply pumps having a large capacity. However, if the capacity of the airtight portion is small, the apparatus itself does not have to be large. As a large airtight part, several people can be accommodated simultaneously. Moreover, as a small airtight part, the airtight part of a capacity | capacitance of the grade which one person lies down is raised.

  In any case, in order to give a subject a stimulus of continuous atmospheric pressure change between a reduced pressure state and a wide normal pressure state, it is preferable to hold at least the entire body inside. Therefore, as the airtight portion of the present invention, the entire human body is held inside. Specifically, the airtight part holds the entire human body inside, and the airtight part is configured as a room where all the human body enters, and the subject enters the airtight room and repeats the pressure change between the reduced pressure state and the wide normal pressure state. . In this case, oxygen deficiency prevention means for preventing oxygen deficiency in the hermetic portion is further provided. Examples of the oxygen deficiency prevention means of the present invention include a door or a vent opening that automatically opens to prevent oxygen deficiency in the airtight portion when compressed air is not supplied due to a power failure or the like.

  In the present invention, details of the effect of improving the ability of living body healing by continuously and repeatedly controlling between a reduced pressure state above a threshold pressure and a normal pressure or a broad normal pressure state higher than the reduced pressure state and lower than the normal pressure. Although the mechanism of action (mechanism of action) is thought to be elucidated by future verification and data accumulation, several hypotheses of mechanism of action were considered.

Hypothesis 1. Low oxygen defense mechanism When the body's “defense mechanism” goes from the lowland to the highland (that is, when the oxygen concentration is low), the theoretical value (the utilization of oxygen in the flatland) is constantly calculated during the movement from the lowland to the highland. It is considered that the amount of oxygen is larger than the amount of oxygen). This indicates that an increase in body temperature is observed even when the moving speed from the normal pressure state to the reduced pressure state is changed, so that production of “ATP” is increased.

  On the contrary, when going from high altitude to low altitude (ie, when going from low oxygen concentration to normal), the defense mechanism works slowly because the oxygen concentration is high, that is, the direction in which cells easily make ATP. To do. Therefore, there is a condition that the theoretical value and the moving speed almost coincide. In order to increase the production of ATP, it is necessary to make the moving speed faster than this. In other words, the faster the speed, the easier it is to produce ATP.

  FIG. 2 is a diagram showing a change in the oxygen utilization rate during expiration when the decompression step and the pressurization step are continuously and repeatedly controlled. This hypothesis focuses on the oxygen utilization rate in exhaled breath due to resting lung respiration. In view of energy metabolism, the amount of oxygen carried by hemoglobin must always be constant in order to produce “ATP”.

  That is, assuming that oxygen equivalent to 25.0% of exhaled air is used on the flat ground, for example, the oxygen concentration decreases by 10% at an altitude of 1000 m, so it is considered that 27.8% oxygen in the exhaled air is used. . Similarly, it is considered that 31.3% is used at an altitude of 2000 m. This is all determined by the function of the biological “defense mechanism”. Up to about 3000m altitude can be converted because there is a surplus in the amount of oxygen in the exhaled breath, but if it becomes thinner than that, there will be individual differences in the amount of oxygen adsorbed to hemoglobin, and so-called “altitude sickness” may occur. is there.

  Therefore, the hypothesis of the hypothetical defense mechanism that the “defense mechanism” acts early and safely when going to danger (low oxygen) and works slowly when going to the safe side (high oxygen) is verified. That is, as shown in FIG. 2, it is considered that the oxygen carrying capacity of hemoglobin shifts to a safer side while the altitude is changing, and a larger amount than the theoretical value is constantly carried. The excess oxygen thus obtained is sent to the mitochondria. As a result, ATP production is increased and body temperature is increased. It is considered that the natural healing power improving effect was obtained by the increased production of ATP.

  In the present invention, since the body temperature increasing effect as a part of the body healing effect was confirmed even by a pressure change corresponding to a pressure reduction / pressure application process that moves a height difference of about 158 m per minute, this “defense mechanism” It is thought that it acts very sensitively.

Hypothesis 2. Signal transduction vascular endothelial cells by secretion of nitric oxide (NO), etc. Gaseous nitric oxide (hereinafter referred to as “NO”) is secreted by stimulation such as shear stress due to blood flow. This NO was called Endothelium-Derived Relaxing Factor (EDRF). This endothelium-derived relaxing factor is shown to be NO itself. F. Mr. Firgotgot, L. J. et al. Mr. Ignalo, F.A. Three of Mr. Murad were awarded the 1998 Nobel Prize in Physiology or Medicine.

  NO as a signaling substance not only prevents plaque from causing infarction of arteries and veins, but also maintains normal blood pressure by preventing arterial relaxation to prevent heart attacks It is known that it is produced in the body, and NO is regarded as a marvelous chemical substance for maintaining the health of the cardiovascular system produced in the body. Hypothesis 2 is that this signal transmission by NO is the main mechanism of action of the natural healing power improving effect of the present invention.

  That is, in the present invention, the period between the reduced pressure state equal to or higher than the threshold pressure and the wide normal pressure state that is higher than the normal pressure or lower than the normal pressure state is repeated, for example, 4 to 5 times within a time period of 40 to 60 minutes. As a result, the blood vessel itself repeats dilatation and return.

  That is, in the living body, blood is transferred with a substantially constant blood pressure. At this time, when the pressure of the outside air surrounding the living body is reduced, the blood vessel expands because the external pressure is lower than the internal pressure. FIG. 3 is an explanatory view for explaining the state of the blood vessel under normal pressure and reduced pressure. As shown in FIG. 3a, at a normal pressure, the blood vessel 2a disposed near the surface of the body 1a is pushed from the outside of the blood vessel 2a with a pressure that can counteract the blood pressure inside the blood vessel 2a. .

  On the other hand, as shown in FIG. 3b, in the reduced pressure state, the pressure itself that pushes the surface of the body 1b is reduced, so that in the blood vessel 2b arranged near the surface of the body 1b, the blood vessel 2b The blood vessel 2b itself is expanded by the blood pressure inside the blood vessel 2b so that the resultant force of the opposing force of the tube wall itself and the pressure from the outside of the blood vessel 2b is balanced with the blood pressure inside the blood vessel 2b.

  When the outside air pressure is restored, the blood vessel returns from the expanded state to the conventional state. The substance that improves the natural healing power is secreted by repeating expansion and restoration as if massaged blood vessels.

  It is well known that NO is secreted by stimulation of shear stress due to blood flow and relaxes vascular smooth muscle cells. In particular, when the body is exposed to an atmosphere in which a reduced pressure state and a broad normal pressure state are continuously repeated as in the present invention, the relaxed state and the return state of the blood vessel are physically repeated continuously. Even if the secretion of NO is more easily promoted than this, it is no wonder that it supports the natural healing power improving effect of the present invention.

As mentioned above, since NO was called endothelium-derived relaxing factor (EDRF), by relaxing the smooth muscle cells of the blood vessels and making the blood vessels muscles flexible and spreading, smoothing the blood flow,
(1) Starting with the effect of lowering blood pressure, it produces various effects as follows. Other effects that have been confirmed are:

(2) Removes free radicals such as active oxygen due to NO being an antioxidant, suppresses platelet aggregation, prevents cholesterol oxidation and thrombus formation, and prevents arteriosclerosis, heart disease, and stroke. Moreover, the blood flow and blood pressure are adjusted and relaxed by NO, and the improvement effect of coldness, a stiff shoulder, and chronic fatigue is also seen.

(3) Activate prostaglandin I ₂ (PGI ₂ ) synthase to increase PGI ₂ production. PGI ₂ works directly on vascular endothelial cells to increase intracellular cAMP concentration and increase NO production. NO synergistically increases the production of prostaglandin I ₂ (PGI ₂ ) (positive feedback).

(4) Blood vessel massage by changes in atmospheric pressure also secretes other signaling substances other than NO.
For example, (4-1) by improving production of plasminogen activator (t-PA), the fibrinolytic system is activated and thrombus is dissolved. As a result, the blood vessel itself rejuvenates, and the effect of preventing abnormal blood pressure reduction, angina pectoris, cerebral thrombus, and intracerebral hemorrhage is achieved.

  In addition, (4-2) B cells and plasma cells (plasma cells) are proliferated by cytokine-induced production (IL-6: regulatory factor of humoral immunity). In addition, production of IgG, IgM, and IgA is enhanced, is involved in T cell differentiation and activation, acts on hepatocytes, and induces acute phase proteins such as CRP and haptoglobin.

Example 1: Verification of improvement effect of living body healing ability Depressurization step to be a depressurized state equal to or higher than a threshold pressure, which is an excessive depressurization, and pressurization step to be a normal pressure or a broad normal pressure state that is higher than the depressurized state and lower than normal pressure With a stimulus that is continuously repeated without a constant pressure state, various subjects have a natural healing effect that attempts to return abnormal body tissues, body organs, etc. to healthy body tissues, body organs It has been confirmed.

  According to an individual subject, the depressurization step for reducing the pressure and the pressurization step for setting the normal pressure or a broad normal pressure state that is higher than the depressurized state and lower than the normal pressure are continuously repeated without a constant pressure state. As a result, the blood flow in the subject's limbs increased, and it was proved that the limbs were warm and warm. Moreover, it was also confirmed that the natural healing power improvement effect appears by repeating a decompression process and a pressurization process continuously. Therefore, the body temperature of the palm (palm) was measured as verification of the effect of the living body healing ability improvement apparatus of this invention. The palm temperature was measured with a skin infrared thermometer (trade name: Thermo Focus Pro).

  4 to 6 are diagrams in which the effect of the living body healing ability improving apparatus is verified, and the vertical axis indicates atmospheric pressure (hPa) and air temperature (° C.), and the horizontal axis indicates time (min). The test subject was the same person in FIGS. 4 to 6, and was performed three or four times after a break of about 1 to 6 hours.

  Fig. 4 shows changes in atmospheric pressure (1013 hPa) and reduced pressure (775.5 hPa) at an altitude of 2200 m, both in the depressurization step and the pressurization step in 4 minutes, and repeated six times in 48 minutes. The measurement result of the body temperature of the subject's palm is shown. In addition, Table 1 shows changes in the body temperature of the subject.

  FIG. 5 shows a cycle in which the pressure reducing step is changed to 1 minute 50 seconds and the pressurizing step is changed from 3 minutes 10 seconds to 50 minutes in a normal pressure state (1013 hPa) and a reduced pressure state at an altitude of 1000 m (898.8 hPa). The measurement result of the body pressure of the subject's palm at the time of the atmospheric pressure change repeated in that time is shown. In addition, Table 2 shows changes in body temperature of subjects.

  Fig. 6 shows changes in atmospheric pressure (1013 hPa) and reduced pressure at an altitude of 600 m (943.2 hPa), with the pressure reducing step repeated for 1 minute and the pressurizing step changed for 2 minutes, continuously repeating 16 times in 51 minutes. And the measurement result of the body temperature of the subject's palm at that time is shown. In addition, Table 3 shows changes in body temperature of subjects.

  As shown in FIGS. 4 to 6 and Tables 1 to 3, the altitude is 1000 m or less as in the case of continuously changing between the reduced pressure state at an altitude of 2000 m or more (about 780 hPa or less) and the normal pressure state (1013 hPa). In the case of continuously changing between the reduced pressure state and the normal pressure state (1013 hPa), the effect of increasing body temperature as part of the living body healing effect was also confirmed. In particular, when the atmospheric pressure change was repeated 16 times continuously at an altitude of 600 m, it was confirmed that the palm temperature after 50 minutes from the first time exceeded 34 ° C., and the effect of the same degree or more was confirmed.

Example 2: Configuration of a device for improving a living body healing ability for high altitude environments In the above-described Example 1, an altitude of 1000 m or less, an altitude, as in the case of continuously changing between a reduced pressure state at an altitude of 2000 m or more and a normal pressure state The same or higher effect was confirmed when continuously changing between the reduced pressure state and the normal pressure state at 600 m. For this reason, by installing the device itself in a high altitude environment, the airtight part and the compressed air supply means as the pressurizing means for pressurizing the air pressure in the airtight part from the reduced pressure state to the wide normal pressure state, and the pressure reduction from the wide normal pressure state A device for improving living body healing ability for high altitude environments, comprising a communication path that connects the inside and outside of the airtight part as a decompression means for decompressing to a state, and a reduced pressure control means that continuously repeats a decompression state and a wide normal pressure state It was created.

  FIG. 7 is an explanatory diagram showing the configuration of an embodiment of the biological healing ability improving device for high altitude environment of the present invention. As shown in the figure, the living body healing ability improving device 10 for high altitude environment of this embodiment is for one person. The hermetic part 11 is a capsule made of fiber reinforced plastic (FRP), and a transparent plastic door 13 for the subject to enter and exit is attached to the hermetic part 11 facing the upper half of the bed 12 on which the subject lies. It has been.

A pressure controller 14 as a reducing pressure control means is provided at one end of the airtight portion 11 on the upper body side of the subject. The pressure controller 14 is provided with a communication path 15 that allows the inside and outside of the airtight part 11 to communicate with each other, and an air supply path 16 that communicates with the air supply pump 18 via a pressure regulating tank 17. While measuring the internal atmospheric pressure, the communication state of the communication passage 15 and the air supply path 16 is controlled, and the atmospheric pressure in the airtight portion 11 is set to a reduced pressure state equal to or higher than a predetermined threshold atmospheric pressure and the normal pressure or the normal pressure. It repeats continuously without pausing between the wide normal pressure state lower than the pressure and higher than the reduced pressure state.

  Although not shown in the figure, this apparatus is equipped with a safety device that prevents the subject from being trapped in the hermetic portion 11. For example, the subject holds the lock switch, and the door 13 is locked while the switch is held. If the switch is removed, the door 13 is unlocked after a certain time, and the confidentiality of the airtight part And a safety device that unlocks the door 13 when the pressure in the airtight portion 11 is further increased beyond normal pressure.

  FIG. 8 is a flowchart showing the drive of the high-health environment biohealing ability improving apparatus of FIG. 7, wherein FIG. 8a is a flowchart showing a pressure reducing process, and FIG. 8b is a flowchart showing a pressurizing process. First, the pressurizing step shown in FIG.

  In the pressurization process, the pressure controller 14 throttles the exhaust valve of the communication passage 15 to the minimum, and increases the opening of the intake valve of the air supply passage 16 to increase the air pressure in the airtight portion 11. The internal pressure is checked every few seconds by a pressure sensor attached to the pressure controller 14 of the hermetic section 11 to determine whether the target pressure value is a preset target pressure value (a wide range of normal pressures). State), the intake valve of the air supply path 16 is squeezed to the minimum, and the process is switched to the pressure reducing process.

  In the depressurization step, the opening degree of the exhaust valve in the communication passage 15 is increased by the pressure controller 14 as shown in FIG. Similar to the pressurization step, the internal pressure is checked every few seconds by a pressure sensor attached to the pressure controller 14 of the airtight section 11 to determine whether the target depressurization value is set in advance, and the target depressurization value is determined. When the value (depressurized state) is reached, the exhaust valve of the communication passage 15 is squeezed to the minimum, and the process is switched to the pressurizing process.

  By controlling the pressure controller 14 as described above, by installing the apparatus itself in a high altitude environment, an airtight part, and a compressed air supply means as a pressurizing means for pressurizing the air pressure in the airtight part from a reduced pressure state to a wide normal pressure state; And a high altitude provided with a communication path that communicates the inside and outside of the hermetic portion as a pressure reducing means for reducing the pressure from a wide normal pressure state to a reduced pressure state, and a pressure reducing pressure control means that continuously repeats the pressure reduction state and the wide normal pressure state. A device for improving the biological healing ability for the environment was obtained.

  FIG. 9 is a diagram schematically showing changes in atmospheric pressure in the hermetic section in the high-health environment biohealing ability improving apparatus of FIG. 7, where the vertical axis represents the equivalent altitude (m) and the horizontal axis represents time (min). As shown in the figure, the installation atmosphere of the device indicated by the broken line is an altitude of 2000 m, the installation atmosphere of the device indicated by the alternate long and short dash line is the altitude of 1000 m, and the installation atmosphere of the device indicated by the solid line Three cases with 500 m are shown.

  At an altitude of 2000 m, it is pressurized to normal pressure at an altitude of 0 m twice in 16 minutes. At an altitude of 1000 m, it is pressurized to atmospheric pressure at an altitude of 0 m four times in the same 16 min. The atmospheric pressure change applied to normal pressure at an altitude of 8 m is described. In these three types of atmospheric pressure changes, the pressure changes per unit time in the decompression step and the pressurization step are the same in these three types, and therefore the distances between the broken lines are equal.

  In this example, the pressure change per unit time between the decompression step and the pressurization step in which the effect of increasing the body temperature was confirmed, and the time of the decompression step and the pressurization step was shortened and repeated. The same or higher body temperature increase effect was confirmed.

  According to the present invention, by setting the place to be installed at a high altitude, a biohealing ability improving device capable of giving better stimulation for improving the natural healing power of the living body can be obtained at low cost, abnormal body tissue, The body healing ability effect which tries to return a body organ etc. to a healthy body tissue and body organ is acquired.

10 ... Biohealing ability improvement device for high altitude environment,
11 ... Airtight part,
12 ... Sleeper,
13 ... door,
14 ... Pressure controller (reducing pressure control means),
15 ... Communication passage,
16 ... Air supply path,
17 ... pressure regulating tank,
18 ... Air supply pump,

Claims (1)

An apparatus for improving the healing ability of a living body, which continuously repeats the air pressure in an airtight part capable of airtightness without stopping between a reduced pressure state equal to or higher than a predetermined threshold pressure and a wide normal pressure state of 1013 hPa to 1000 hPa ,
Said airtight unit, a pressurization means for pressurizing the air pressure in the airtight portion from said reduced pressure condition to a wide range normal pressure of the 1013HPa～1000hPa, pressure reducing means for reducing the pressure to the reduced pressure state from a wide normal pressure of the 1013HPa～1000hPa And a body healing ability improving device comprising a reduced pressure control means for controlling the pressurizing means and the pressure reducing means to continuously repeat a reduced pressure state and a wide normal pressure state of 1013 hPa to 1000 hPa .
The installation atmosphere of the device is atmospheric pressure corresponding to an altitude of altitude 400 m to altitude 1000 m,
As the depressurization means, a communication path for depressurizing to the atmospheric pressure of the installation atmosphere by communicating the inside and outside of the hermetic part in a depressurization step of depressurization from the wide normal pressure state of 1013 hPa to 1000 hPa to the depressurization state,
As the pressurizing means, an air supply path for supplying compressed air into an airtight part in a pressurizing step of pressurizing from the reduced pressure state to the wide normal pressure state of 1013 hPa to 1000 hPa ,
The reduced pressure control means controls the communication state of the communication passage and the air supply passage while measuring the pressure inside the airtight portion, and reduces the pressure inside the airtight portion to a reduced pressure state equal to or higher than the threshold pressure. It repeats continuously without pausing between a wide range of normal pressures of 1013 hPa to 1000 hPa, and it switches to the pressurizing step before the reduced pressure state is completely returned to the atmospheric pressure of the installation atmosphere. Yes,
The pressure change per unit time in the depressurization step and the pressurization step during continuous repetition of the depressurized state and the wide range normal pressure state of 1013 hPa to 1000 hPa is 19 hPa / min to 70 hPa / min A device for improving living body healing ability for high altitude environments.

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