JP6155022B2 - Oral composition - Google Patents

Description

  The present invention relates to an oral composition.

The main component of the tooth is hydroxyapatite, and in the mouth, the elution (decalcification) of phosphate ions and calcium ions and the crystallization (remineralization) to calcium phosphate and hydroxyapatite are usually in an equilibrium state. Dental caries promotes decalcification by causing bacteria such as Streptococcus mutans to decompose sucrose and produce organic acids, lowering pH, and eluting tooth calcium and the like It will go on. In the initial stages of caries, enamel produces subsurface demineralized lesions of the teeth called white spots. Here fluoride ion (F ^-) is incorporated into the tooth to form calcium fluoride, a low concentration of fluoride ions that gradually release, and demineralization inhibiting effect of the teeth, calcium and phosphate ions The effect of crystallization, that is, the remineralization effect is exhibited. Therefore, it is known that fluoride ions can prevent caries and eliminate such vitiligo.

  On the other hand, among the anionic surfactants, N-acylamino acid or a salt thereof is hypoallergenic and, for example, as disclosed in Patent Document 1, provides excellent foaming properties and good flavor. As an alternative component such as an alkyl sulfate, it is used in various oral compositions. Further, as disclosed in Patent Document 2, N-acylamino acid or a salt thereof is also known to exhibit an effect of inhibiting the formation of stains. A non-aerosol foam dentifrice product is disclosed in which foam quality is improved by using it together with alcohol.

  Realizing an oral composition capable of effectively incorporating fluoride ions while using such an N-acylamino acid or a salt thereof having excellent performance is extremely effective in preventing the occurrence of caries. Useful. For example, Patent Document 4 discloses an oral composition containing aluminum hydroxide, an N-long chain acylamino acid, and a fluorine compound.

JP-A-56-97215 Japanese Patent Laid-Open No. 10-17444 Japanese Patent Laid-Open No. 10-87460 JP-A-2-233607

  However, in any of the compositions described in any document, the amount of fluoride ions adsorbed on teeth is not sufficiently increased while using N-acylamino acid or a salt thereof, and further improvement is required.

  The present invention relates to an oral composition capable of effectively preventing the occurrence of caries by sufficiently increasing the amount of fluoride ions adsorbed on teeth while using an N-acyl acidic amino acid or a salt thereof.

  Therefore, the present inventor effectively adsorbs fluoride ions to teeth by using N-acyl acidic amino acid or a salt thereof and a specific sugar alcohol in the presence of a fluoride ion supply compound and sufficient water. In addition, by specifying the content and ratio of these together with the content of sodium chloride, an oral composition capable of dramatically increasing the amount of fluoride ions taken into the teeth is obtained. I found out that

That is, the present invention includes the following components (A) to (D):
(A) N-acyl acidic amino acid or salt thereof 0.005% by mass to 1% by mass (B) Sugar alcohol having a solubility in water at 20 ° C. of 40% by mass or less 2% by mass to 40% by mass (C) One or more fluoride ion supply compounds selected from sodium fluoride, ammonium fluoride, potassium fluoride and sodium fluoride siliconate (D) Water containing more than 25% by mass and 95% by mass or less The content of sodium is 3% by mass or less, the mass ratio (B) / (A) of component (B) to component (A) is 5 or more and 8000 or less, and component (A) and component (D) An oral composition having a mass ratio (A) / (D) of 0.006 × 10 ⁻² or more and less than 4 × 10 ⁻² is provided.

  According to the composition for oral cavity of the present invention, the amount of fluoride ions taken up into the teeth is effectively increased by the sufficient water content and the combined use of the N-acyl acidic amino acid or its salt and a specific sugar alcohol. Therefore, the occurrence of caries can be effectively prevented.

Hereinafter, the present invention will be described in detail.
The composition for oral cavity of the present invention has the following components (A) to (D):
(A) N-acyl acidic amino acid or salt thereof 0.005% by mass to 1% by mass (B) Sugar alcohol having a solubility in water at 20 ° C. of 40% by mass or less 2% by mass to 40% by mass (C) One or more fluoride ion supply compounds selected from sodium fluoride, ammonium fluoride, potassium fluoride and sodium fluoride siliconate (D) Water containing more than 25% by mass and 95% by mass or less The content of sodium is 3% by mass or less, the mass ratio (B) / (A) of component (B) to component (A) is 5 or more and 8000 or less, and component (A) and component (D) The mass ratio (A) / (D) is 0.006 × 10 ⁻² or more and less than 4 × 10 ⁻² . The form of the oral composition is not particularly limited as long as it can be applied in the mouth, and is a dentifrice composition such as a toothpaste or a gel-like dentifrice, or a liquid oral composition such as a mouthwash or a liquid dentifrice. It can be used as a product.

  The composition for oral cavity of this invention contains 0.005 mass% or more and 1 mass% or less of N-acyl acidic amino acids or its salt as a component (A). With this component (A), the amount of fluoride ions taken into the teeth can be increased in combination with other components to be described later while being hypoallergenic. The acyl group of component (A) is preferably derived from a saturated or unsaturated linear or branched fatty acid having 8 to 18 carbon atoms from the viewpoint of bubbling or the like, saturated or unsaturated linear or What derived from the C8-C16 fatty acid which has a branched chain is more preferable, and what derived from the C8-C14 fatty acid which has a saturated or unsaturated linear or branched chain is more preferable. Examples of such fatty acids include caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid and the like. Among these fatty acids, lauric acid, myristic acid, palmitic acid, and oleic acid are preferable from the viewpoint of foam quality and storage stability, and lauric acid is more preferable. The acyl group of component (A) may be derived from a mixed fatty acid of the above fatty acids, for example, coconut oil, palm kernel oil, or the like. Especially, what was obtained from coconut oil fatty acid and palm kernel fatty acid as a raw material is preferable, and what was obtained from coconut oil fatty acid as a raw material is more preferable. The acyl group of component (A) can be derived from one or more selected from such fatty acids.

  The acidic amino acid moiety of the component (A) is preferably one or two selected from glutamic acid and aspartic acid, and more preferably glutamic acid from the viewpoint of increasing the amount of fluorine uptake. Further, these amino acid moieties may be any of D-form, L-form, or a mixture of D-form and L-form, and is preferably L-form.

  From the viewpoint of increasing the fluorine uptake amount, the N-acyl acidic amino acid or salt thereof (A) is N-lauroyl glutamic acid, N-cocoyl glutamic acid, N-myristoyl glutamic acid, N-palm fatty acid glutamic acid, N-lauroyl aspartic acid, And one or more selected from these salts, N-lauroylglutamic acid, N-cocoylglutamic acid, and one or more selected from these salts are more preferable, N-cocoylglutamic acid or a salt thereof Is more preferable.

  From the viewpoint of easy use in the oral cavity and the stability of the composition, alkali metal salts such as sodium salts and potassium salts; ammonium salts; arginine salts , Basic amino acid salts such as lysine salt, histidine salt and ornithine salt. The salt of component (A) is preferably one or more selected from alkali metal salts and arginine salts from the viewpoint of the stability and taste of the composition and availability, and is preferably a sodium salt, potassium salt or arginine salt. 1 type or 2 types or more selected from are more preferable, 1 type or 2 types selected from sodium salt and potassium salt are still more preferable, and sodium salt is still more preferable.

  The content of component (A) is 0.005% by mass or more, preferably 0.01% by mass or more, from the viewpoint of increasing the amount of fluoride ions taken into the teeth. Content of a component (A) is 1 mass% or less from a viewpoint of taste or irritation, Preferably it is 0.8 mass% or less, More preferably, it is 0.5 mass% or less. Moreover, content of a component (A) is 0.005-1 mass%, Preferably it is 0.01-0.8 mass%, More preferably, it is 0.01-0.5 mass%. .

For example, when the oral composition of the present invention is a liquid oral composition, the content of the component (A) is preferably 0.5 from the viewpoints of taste and irritation, solubility and storage stability. It is not more than mass%, more preferably not more than 0.2 mass%, and still more preferably not more than 0.1 mass%.
Further, for example, when the oral composition of the present invention is a dentifrice composition, the content of the component (A) is 1% by mass or less, preferably 0.8% from the viewpoints of taste, irritation and manufacturability. % Or less, and more preferably 0.5% by mass or less.

  The composition for oral cavity of the present invention contains 2% by mass or more of a sugar alcohol having a solubility in water at 20 ° C. of 40% by mass or less (dissolution amount in 100 g of saturated aqueous solution at 20 ° C. is 40 g or less) as the component (B). Contain less than mass%. This solubility is preferably 5% by mass or more and 40% by mass or less, more preferably 10% by mass or less, from the viewpoint of dissolving well in the composition and effectively increasing the amount of fluoride ions taken into the teeth in combination with other components. % To 40% by mass is more preferable, and 20% to 35% by mass is more preferable. The sugar alcohol of component (B) is preferably one or more selected from erythritol, reduced palatinose, glucopyranosyl sorbitol, glucopyranosyl mannitol, and mannitol, and more specifically, erythritol, mannitol. , Α-D-glucopyranosyl-1,6-sorbitol, α-D-glucopyranosyl-1,6-mannitol, a mixture of α-D-glucopyranosyl-1,6-sorbitol and α-D-glucopyranosyl-1,6-mannitol And reduced palatinose. Among them, one or more selected from erythritol, reduced palatinose and mannitol is more preferable from the viewpoint of low solubility in water, ease of handling, and promotion of fluorine uptake, and appropriate solubility. From the viewpoint of effectively increasing the fluorine uptake amount, one or two selected from erythritol and reduced palatinose are more preferable.

  As the structure of erythritol, there are three isomers of L-erythritol, D-erythritol, and meso-erythritol. In the present invention, any of these structures may be used. For example, as crystalline erythritol, commercially available products such as those manufactured by Nikken Chemical Co., Ltd., Mitsubishi Chemical Foods Co., Ltd., and Celestor are available. The solubility of erythritol in water at 20 ° C. is 33% by mass (the amount dissolved in 100 g of a saturated aqueous solution at 20 ° C. is 33 g).

  Reduced palatinose is a disaccharide sugar alcohol and is an equimolar mixture of α-D-glucopyranosyl-1,6-mannitol and its isomer α-D-glucopyranosyl-1,6-sorbitol. Reduced palatinose is obtained by using sucrose as a raw material, converting sucrose to palatinose with a glycosyltransferase, and then carrying out a hydrogenation reaction. Further, Palatinit known as reduced palatinose is a trade name of Mitsui Sugar Co., Ltd. and Suducker AG (Japanese name: South German Sugar Co., Ltd.), and there is another name called isomalt. The solubility of paratinite in water at 20 ° C. is 28% by mass (the amount dissolved in 100 g of a saturated aqueous solution at 20 ° C. is 28 g).

  Mannitol is a kind of hexitol and is a sugar alcohol of mannose. Industrially, it is produced by electrolytic reduction of corn starch sugar and high-pressure reduction of sucrose. The mannitol used in the present invention is not particularly limited as long as it is at least one selected from D-mannitol, L-mannitol, and D, L-mannitol, but D-mannitol existing in nature is available. Easy and preferred. The solubility of mannitol in water at 20 ° C. is 18% by mass (18 g dissolved in 100 g of a saturated aqueous solution at 20 ° C.).

  The content of component (B) is the composition for oral cavity of the present invention from the viewpoint of effectively increasing the amount of fluoride ions taken into the teeth by dissolving a sufficient amount of component (B) in the composition. It is 2 mass% or more and 40 mass% or less. For example, when the composition for oral cavity of the present invention is a liquid composition for oral cavity, the content of such component (B) is the composition for oral cavity of the present invention from the viewpoint of increasing the amount of fluoride ions taken into the teeth. It is 2 mass% or more in a thing, Preferably it is 5 mass% or more, More preferably, it is 8 mass% or more. When the oral composition of the present invention is a liquid oral composition, the content of the component (B) is such that the component (B) is dissolved well in the composition from the viewpoint of dissolving the component (B) in the composition. The content is preferably 25% by mass or less, more preferably 20% by mass or less. When the oral composition of the present invention is a liquid oral composition, the content of the component (B) is preferably 2 to 25% by mass in the oral composition of the present invention, More preferably, it is 5-25 mass%, More preferably, it is 8-20 mass%.

  For example, when the oral composition of the present invention is a dentifrice composition, the content of such component (B) is the present invention from the viewpoint of increasing the amount of fluoride ions taken into the tooth while obtaining a good taste. In the composition for oral cavity, it is 2 mass% or more, Preferably it is 5 mass% or more, More preferably, it is 10 mass% or more, More preferably, it is 15 mass% or more. When the composition for oral cavity of this invention is a dentifrice composition, content of this component (B) dissolves a component (B) favorably in a composition, or the component (A) and component in a composition From the viewpoint of securing the fluidity of (B) and promoting the incorporation of fluoride ions into the teeth, it is 40% by mass or less in the oral composition of the present invention, preferably 35% by mass or less. More preferably, it is 30 mass% or less. Moreover, when the composition for oral cavity of this invention is a dentifrice composition, content of this component (B) becomes like this. Preferably it is 2-40 mass% in the composition for oral cavity of this invention, More preferably, it is 5 It is -35 mass%, More preferably, it is 10-30 mass%, More preferably, it is 15-30 mass%.

  The composition for oral cavity of this invention can contain sugar alcohols other than a component (B) whose solubility with respect to water in 20 degreeC exceeds 40 mass%. The content of the sugar alcohol other than the component (B) is sufficient to secure the fluidity of the component (A) and the component (B) in the composition from the viewpoint of better dissolving the component (B) in the composition. From this viewpoint, the content is preferably 35% by mass or less, and more preferably 30% by mass or less. In the case of containing a sugar alcohol other than the component (B), the content is preferably 2% by mass or more, more preferably 4% by mass or more, from the viewpoint of good taste and wet effect. When the composition for oral cavity of this invention is a dentifrice composition, content of sugar alcohol other than a component (B) becomes like this. More preferably, it is 10 mass% or more. In the case where the oral composition of the present invention is a liquid oral composition, the content of the sugar alcohol other than the component (B) is a viewpoint in which the component (B) is dissolved better in the composition, or in the composition. From the viewpoint of ensuring sufficient fluidity of the component (A) and the component (B), it is preferably 15% by mass or less, and more preferably 10% by mass or less. Examples of sugar alcohols other than the component (B) include xylitol having a solubility in water at 20 ° C. of 66 mass% (dissolved in 100 g of a saturated aqueous solution at 20 ° C.) and 60 mass% (20 ° C. in water at 20 ° C.). And sorbitol having a solubility in water at 20 ° C. of 72% by mass (dissolved in 100 g of saturated aqueous solution at 20 ° C.).

  The mass ratio (B) / (A) of the component (B) and the component (A) is 5 or more from the viewpoint of increasing the amount of fluoride ions taken into the teeth by combining the component (A) and the component (B). Thus, it is preferably 10 or more, more preferably 20 or more. The mass ratio (B) / (A) of the component (B) to the component (A) is 8000 or less from the viewpoint of increasing the amount of fluoride ions taken into the teeth by combining the component (A) and the component (B). Thus, it is preferably 2000 or less, and more preferably 1000 or less. Moreover, mass ratio (B) / (A) of a component (B) and a component (A) is 5-8000, Preferably it is 10-2000, More preferably, it is 20-1000.

For example, when the oral composition of the present invention is a liquid oral composition, from the viewpoint of increasing the fluoride ion uptake amount, and from the viewpoint of stability and taste, the mass ratio of the component (B) to the component (A) ( B) / (A) is 5 or more, preferably 25 or more, more preferably 80 or more, preferably 5000 or less, more preferably 2000 or less, and even more preferably 1000 or less. is there. Moreover, when the composition for oral cavity of this invention is a composition for liquid oral cavity, mass ratio (B / A) of a component (B) and a component (A) becomes like this. Preferably it is 5-5000, More preferably, it is 25- It is 2000, More preferably, it is 80-1000.
For example, when the oral composition of the present invention is a dentifrice composition, the mass ratio (B) / (A) of the component (B) to the component (A) is 5 or more from the viewpoint of increasing the amount of fluoride ion uptake. It is preferably 10 or more, more preferably 20 or more, still more preferably 30 or more, preferably 3000 or less, more preferably 2000 or less, and still more preferably 1000 or less. Moreover, when the composition for oral cavity of this invention is a dentifrice composition, mass ratio (B) / (A) of a component (B) and a component (A) becomes like this. Preferably it is 10-3000, More preferably, 20- It is 2000, More preferably, it is 30-1000.

  The composition for oral cavity of this invention contains the fluoride ion supply compound which is 1 type, or 2 or more types chosen from sodium fluoride, ammonium fluoride, potassium fluoride, and sodium fluorosilicate as a component (C) To do. The component (C) is a compound that releases fluoride ions in an aqueous solution. Among these, sodium fluoride and ammonium fluoride are more preferable, and sodium fluoride is more preferable from the viewpoint of high fluoride ion uptake into tooth enamel and the like. Moreover, sodium monofluorophosphate can also be used together as fluorides other than the fluoride ion supply compound (C) that do not directly supply fluoride ions.

  The content of the component (C) is preferably a fluorine atom equivalent amount in the oral composition of the present invention, from the viewpoint of ensuring sufficient fluoride ion uptake with respect to tooth enamel and the like, and preferably It is 0.002 mass% or more, More preferably, it is 0.01 mass% or more, More preferably, it is 0.02 mass% or more. Content of a component (C) is 2 mass% or less from viewpoints of safety etc., More preferably, it is 1 mass% or less, More preferably, it is 0.5 mass% or less. Moreover, content of a component (C) is a fluorine atom conversion amount in the composition for oral cavity of this invention, Preferably it is 0.002-2 mass%, More preferably, it is 0.01-1 mass%. More preferably, it is 0.02-0.5 mass%.

  The mass ratio (C) / (A) of the component (C) to the component (A) is preferably 0.01 or more, more preferably 0.05, from the viewpoint of promoting the incorporation of fluoride ions into the teeth. It is above, More preferably, it is 0.1 or more, More preferably, it is 0.2 or more. The mass ratio (C) / (A) of the component (C) and the component (A) is preferably 100 or less, more preferably 50 or less, from the viewpoint of efficiently incorporating fluoride ions into the teeth. Preferably it is 10 or less, More preferably, it is 5 or less. Moreover, the mass ratio (C) / (A) of the component (C) and the component (A) is preferably 0.01 to 100, more preferably 0.05 to 50, and still more preferably 0.1. Is 10 to 10, more preferably 0.2 to 5. For example, when the oral composition of the present invention is a liquid oral composition, the mass ratio (C) / (A) of the component (C) and the component (A) is preferably 0.01 to 100, More preferably, it is 0.05-50, More preferably, it is 0.2-10, More preferably, it is 0.2-5. For example, when the oral composition of the present invention is a dentifrice composition, the mass ratio (C) / (A) of the component (C) to the component (A) is preferably 0.01 to 100, more preferably. It is 0.05-50, More preferably, it is 0.05-10, More preferably, it is 0.1-5.

  The composition for oral cavity of this invention contains more than 25 mass% and 95 mass% or less of water as a component (D). Thereby, while dissolving component (B) satisfactorily, other components can also be dissolved or dispersed satisfactorily, and the incorporation of fluoride ions into the teeth can be promoted. For example, when the composition for oral cavity of the present invention is a liquid composition for oral cavity, the content of such component (D) is in the composition for oral cavity of the present invention from the viewpoint of dissolving or dispersing each component well. , Preferably it is 50 mass% or more, More preferably, it is 60 mass% or more, More preferably, it is 70 mass% or more. When the composition for oral cavity of the present invention is a liquid composition for oral cavity, the content of such component (D) is the composition for oral cavity of the present invention from the viewpoint of effectively promoting the incorporation of fluoride ions into the teeth. The content is 95% by mass or less, preferably 90% by mass or less. Moreover, when the composition for oral cavity of this invention is a liquid composition for oral cavity, content of this component (D) becomes like this. Preferably it is 50-95 mass%, More preferably, it is 60-90 mass%, More preferably, it is 70-90 mass%.

  For example, when the oral composition of the present invention is a dentifrice composition, the content of the component (D) is such that each component is dissolved or dispersed well, and the synergistic effect of the component (A) and the component (B) From the viewpoint of effectively promoting the uptake of fluoride ions, the composition for oral cavity of the present invention exceeds 25% by mass, preferably 26% by mass or more, and more preferably 27% by mass or more. When the composition for oral cavity of the present invention is a dentifrice composition, the content of such component (D) is sufficient for the incorporation of fluoride ions into the tooth while maintaining good shape retention and viscosity as a dentifrice composition. From the viewpoint of effectively promoting, the composition for oral cavity of the present invention is preferably 70% by mass or less, more preferably 60% by mass or less, and further preferably 50% by mass or less. Moreover, when the composition for oral cavity of this invention is a dentifrice composition, content of this component (D) is a viewpoint which ensures the balance of the solubility or dispersibility of each component, and shape retention property, and fluoride ion. In the composition for oral cavity of the present invention, it is preferably more than 25% by mass and less than 70% by mass, more preferably more than 25% by mass and less than 60% by mass, More preferably, it is 26-50 mass%, More preferably, it is 27-50 mass%.

The mass ratio (A) / (D) of the component (A) to the component (D) is 0.006 from the viewpoint of favorably dissolving the component (A) and favorably promoting the incorporation of fluoride ions into the teeth. × 10 ⁻² or more and less than 4 × 10 ⁻² . For example, when the oral composition of the present invention is a liquid oral composition, it is preferably 0.01 × 10 ⁻² or more, more preferably 0.012 × 10 ⁻² or more, preferably 0. It is 8 × 10 ⁻² or less, more preferably 0.3 × 10 ⁻² or less, and further preferably 0.14 × 10 ⁻² or less.
For example, when the oral composition of the present invention is a dentifrice composition, the mass ratio (A) / (D) of the component (A) to the component (D) is determined by the ratio of fluoride ions to the teeth by the component (A). From the viewpoint of promoting uptake, it is preferably 0.01 × 10 ⁻² or more, more preferably 0.02 × 10 ⁻² or more, preferably 3 × 10 ⁻² or less, more preferably 2 ×. 10 ⁻² or less, more preferably 1.5 × 10 ⁻² or less.

  The oral composition of the present invention preferably further contains a component (E) selected from glycerin and propylene glycol from the viewpoint of further promoting the incorporation of fluoride ions into the teeth. The component (E) is preferably glycerin from the viewpoint of further promoting the uptake of fluoride ions into the teeth and the taste. The content of the component (E) is preferably 2% by mass or more, more preferably 4% by mass or more in the oral composition of the present invention from the viewpoint of promoting the incorporation of fluoride ions into the teeth. In the case where the oral composition of the present invention is a dentifrice composition, it is more preferably 5% by mass or more, and further preferably 7% by mass or more. The content of the component (E) is preferably 30% by mass or less in the oral composition of the present invention from the viewpoint of maintaining a good feeling of use and taste while promoting the incorporation of fluoride ions into the teeth. Yes, more preferably 20% by mass or less, still more preferably 15% by mass or less. In addition, the content of the component (E) is preferably 2 to 30% by mass, more preferably 4 to 20% by mass in the oral composition of the present invention. When it is a dentifrice composition, More preferably, it is 5-15 mass%, More preferably, it is 7-15 mass%.

  The oral composition of the present invention has a sodium chloride content of 3 in the oral composition of the present invention from the viewpoint of further promoting the uptake of fluoride ions into the teeth and maintaining a good flavor. It is preferably at most mass%, more preferably at most 1 mass%, further preferably at most 0.1 mass%, further preferably at most 0.01 mass%, and unavoidably. It is preferable not to contain sodium chloride except when mixed. In addition, the composition for oral cavity of the present invention has a potassium chloride content of the composition for oral cavity of the present invention from the viewpoint of further promoting the uptake of fluoride ions into the teeth and maintaining a good flavor. It is preferably 1% by mass or less, more preferably 0.1% by mass or less, still more preferably 0.01% by mass or less, and unless inevitably mixed, It is preferable not to contain potassium.

  The composition for oral cavity of the present invention further includes a wetting agent other than glycerin such as polyethylene glycol, 1,3-butylene glycol, dipropylene glycol and the like; a sweetener such as saccharin sodium and sucralose; Fragrances such as menthol and anethole; nonionic surfactants such as glycerin fatty acid ester and polyoxyethylene hydrogenated castor oil; anionic surfactants such as sodium lauryl sulfate; pH adjusting agents; bactericides; anti-inflammatory agents; An agent; a plant extract; and other active ingredients can be contained.

  In the composition for oral cavity of the present invention, the content of the compound that supplies polyvalent metal ions such as magnesium ion, aluminum ion, calcium ion, etc. In the oral composition of the present invention in terms of ions, it is preferably 0.1% by mass or less, more preferably 0.01% by mass or less, and further preferably 0.001% by mass or less. Moreover, it is preferable not to contain the compound which supplies a polyvalent metal ion except the case where it inevitably mixes.

  In the oral composition of the present invention, the content of condensed phosphoric acid such as pyrophosphoric acid and tripolyphosphoric acid is preferably in the oral composition of the present invention from the viewpoint of further promoting the incorporation of fluoride ions into the teeth. Is 0.1% by mass or less, more preferably 0.01% by mass or less, and it is preferable not to contain condensed phosphoric acid unless it is inevitably mixed.

  When the oral composition of the present invention is a dentifrice composition, it is preferable to contain a binder from the viewpoints of shape retention, ease of use, and storage stability. Examples of the binder contained in the dentifrice composition of the present invention include sodium carboxymethyl cellulose, carrageenan, xanthan gum, hydroxyethyl cellulose, hydroxypropyl cellulose, sodium alginate, sodium polyacrylate, polyvinyl alcohol and the like. It is preferable to use seeds or two or more kinds. Among these, sodium carboxymethylcellulose, carrageenan, xanthan gum, hydroxyethylcellulose, and hydroxypropylcellulose are preferable, and it is preferable to use a combination of two or more from the viewpoint of improving the feeling of use while suppressing stringiness. The content of the binder in the dentifrice composition of the present invention is preferably 0.2 to 3% by mass, more preferably 0.4 to 2% by mass, and further preferably 0.5 to 1.5%. % By mass.

  Moreover, when the composition for oral cavity of this invention is a dentifrice composition, it is preferable to use a thickening silica together with the said binder. The thickening silica is silica having an oil absorption of 200 to 400 mL / 100 g. Here, the amount of oil absorption indicates the amount of oil that can be supported by silica, and the measuring method is specified by the method of JIS K5101-13-2 (established in 2004) and specified by the amount of oil that is absorbed in the boiled sea bream. To do. The content of the thickening silica is preferably 0.5 to 10% by mass in the dentifrice composition of the present invention.

  The composition for oral cavity of this invention can be used in order to accelerate | stimulate the fluorine uptake | capture amount to a tooth | gear, and can be used as the fluorine uptake | capture amount promoter to a tooth | gear. When the oral composition of the present invention is a liquid oral composition, the liquid oral composition of the present invention is preferably applied 1 to 5 times a day, more preferably 1 to 3 times a day, preferably 3 -50 mL, more preferably 5-25 mL in the oral cavity, preferably 5 seconds to 1 minute, and more preferably 10 seconds to 40 seconds, and preferably applied by discharging, liquid oral composition It is more preferable to brush the teeth before the object is contained in the oral cavity. In addition, the liquid oral composition of the present invention can be applied by applying a non-woven fabric or the like to the tooth, or can be applied in a state where the tooth is immersed with a mouthpiece or the like, preferably 30 seconds to 10 minutes, More preferably, it is applied for 1 minute to 5 minutes. When the oral composition of the present invention is a dentifrice composition, it is preferable to brush with a toothbrush using the dentifrice composition of the present invention, preferably 1 to 5 times a day, more preferably 1 to 3 times a day. The amount used is preferably 0.2-3 g, more preferably 0.5-2 g, and the time for brushing with a toothbrush is preferably 30 seconds to 10 minutes, more preferably 1 minute- 5 minutes.

In relation to the embodiments described above, the present invention further discloses the use of the following oral compositions and oral compositions.
[1] The following components (A) to (D):
(A) N-acyl acidic amino acid or salt thereof 0.005% by mass to 1% by mass (B) Sugar alcohol having a solubility in water at 20 ° C. of 40% by mass or less 2% by mass to 40% by mass (C) One or more fluoride ion supply compounds selected from sodium fluoride, ammonium fluoride, potassium fluoride and sodium fluoride siliconate (D) Water containing more than 25% by mass and 95% by mass or less The content of sodium is 3% by mass or less, the mass ratio (B) / (A) of component (B) to component (A) is 5 or more and 8000 or less, and component (A) and component (D) The composition for oral cavity whose mass ratio (A) / (D) is 0.006 * 10 ^<-2 > or more and less than 4 * 10 ^{< -2} >.

[2] The composition for oral cavity according to the above [1], wherein the solubility of the component (B) in water at 20 ° C. is preferably 5% by mass or more.
[3] Component (B) is preferably one or more selected from erythritol, reduced palatinose, glucopyranosyl sorbitol, glucopyranosyl mannitol and mannitol, more preferably mannitol, α-D- Reduced palatinose, which is a mixture of glucopyranosyl-1,6-sorbitol, α-D-glucopyranosyl-1,6-mannitol, and α-D-glucopyranosyl-1,6-sorbitol and α-D-glucopyranosyl-1,6-mannitol 1 or more selected from the group consisting of erythritol, reduced palatinose, glucopyranosyl sorbitol, and glucopyranosyl mannitol, or more preferably erythritol and Choose from reduced palatinose One or a is the [1] or oral composition [2] is.

[4] The acyl group of component (A) is preferably derived from a saturated or unsaturated linear or branched fatty acid having 8 to 18 carbon atoms, saturated or unsaturated having 8 to 16 carbon atoms. Those derived from a fatty acid having a straight chain or branched chain are more preferable, and those derived from a fatty acid having a saturated or unsaturated linear or branched chain having 8 to 14 carbon atoms are more preferable. 3] Any one oral cavity composition.
[5] The acyl group of component (A) is one or more selected from caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, coconut oil fatty acid and palm kernel fatty acid. Those derived from fatty acids are preferred, those derived from one or more fatty acids selected from lauric acid, myristic acid, oleic acid, palmitic acid, palm oil fatty acid and palm kernel fatty acid are more preferred, and lauric acid The composition for oral cavity according to any one of the above [1] to [4], wherein one derived from one or two fatty acids selected from coconut oil fatty acids is more preferable, and one derived from coconut oil fatty acids is still more preferable. object.
[6] The acidic amino acid moiety of component (A) is preferably one or two selected from glutamic acid and aspartic acid, and more preferably glutamic acid, any one of the above [1] to [5] Oral composition.

[7] The N-acyl acidic amino acid of component (A) is selected from N-lauroyl glutamic acid, N-cocoyl glutamic acid, N-myristoyl glutamic acid, N-palm fatty acid glutamic acid, N-lauroyl aspartic acid, and salts thereof 1 1 type or 2 or more types are preferable, 1 type or 2 or more types chosen from N-lauroyl glutamic acid, N-cocoyl glutamic acid, and these salts are preferable, More preferably, it is said N-cocoyl glutamic acid or its salt [1] [6] The composition for oral cavity of any one.
[8] The salt of the N-acyl acidic amino acid of component (A) is preferably one or more selected from alkali metal salts, ammonium salts and basic amino acid salts, and is selected from alkali metal salts and arginine salts. One or two or more species selected from sodium salts and potassium salts are more preferable, and the oral composition according to any one of [1] to [7] above, more preferably a sodium salt.
[9] The content of component (A) is 0.005% by mass or more, preferably 0.01% by mass or more, 1% by mass or less, preferably 0.8% by mass or less. The composition for oral cavity according to any one of the above [1] to [8], which is more preferably 0.5% by mass or less.

[10] The mass ratio (B) / (A) of the component (B) to the component (A) is 5 or more, preferably 10 or more, more preferably 20 or more, and 8000 or less, The composition for oral cavity according to any one of the above [1] to [9], which is preferably 2000 or less, more preferably 1000 or less.
[11] The content of the component (C) is preferably 0.002% by mass or more, more preferably 0.01% by mass or more, further preferably 0.02% by mass or more, preferably 2 The composition for oral cavity according to any one of the above [1] to [10], wherein the composition is 1% by mass or less, more preferably 1% by mass or less, and still more preferably 0.5% by mass or less.
[12] The mass ratio (C) / (A) of the component (C) to the component (A) is preferably 0.01 or more, more preferably 0.05 or more, and further preferably 0.1 [1] above, more preferably 0.2 or more, preferably 100 or less, more preferably 50 or less, further preferably 10 or less, and even more preferably 5 or less. [11] The composition for oral cavity of any one.

[13] The content of sodium chloride is preferably 3% by mass or less, more preferably 1% by mass or less, more preferably 0.1% by mass or less, and further preferably 0.01% by mass. The composition for oral cavity according to any one of the above [1] to [12], which is preferably the following and preferably does not contain sodium chloride.
[14] The content of potassium chloride is preferably 1% by mass or less, more preferably 0.1% by mass or less, still more preferably 0.01% by mass or less, and preferably potassium chloride. The composition for oral cavity according to any one of [1] to [13], which is not contained.
[15] Preferably the component (E) selected from glycerin and propylene glycol is contained, preferably the component (E) is glycerin, and the content of the component (E) is preferably 2% by mass or more, more preferably. Is 4% by mass or more, preferably 30% by mass or less, more preferably 20% by mass or less, and still more preferably 15% by mass or less, and any one of the above [1] to [14] for oral cavity Composition.

[16] Preferably, the composition is a liquid oral composition, the content of the component (A) is 0.005% by mass or more and 0.5% by mass or less, and the content of the component (B) is 2% by mass. It is 25 mass% or less, the content of the component (D) is 50 mass% or more and 95 mass% or less, and the mass ratio (B) / (A) of the component (B) to the component (A) is 5 or more and 5000. And the mass ratio (A) / (D) of the component (A) to the component (D) is preferably 0.01 × 10 ⁻² or more and 0.8 × 10 ⁻² or less [1] to [15] The composition for oral cavity according to any one.
[17] Preferably, the composition is a liquid oral composition, and the content of the component (A) is 0.005% by mass or more, preferably 0.01% by mass or more, preferably 0.5 The composition for oral cavity according to any one of the above [1] to [16], which is not more than mass%, more preferably not more than 0.2 mass%, and still more preferably not more than 0.1 mass%.
[18] Preferably, it is a liquid oral composition, and the content of the component (B) is 2% by mass or more, preferably 5% by mass or more, more preferably 8% by mass or more. The composition for oral cavity according to any one of [1] to [17], preferably 25% by mass or less, more preferably 20% by mass or less.
[19] Preferably, the composition is a liquid oral composition, and the mass ratio (B) / (A) of the component (B) to the component (A) is 5 or more, preferably 25 or more, more Preferably it is 80 or more, Preferably it is 5000 or less, More preferably, it is 2000 or less, More preferably, it is 1000 or less, The composition for oral cavity of any one of said [1]-[18].

[20] It is preferably a liquid oral composition, and the mass ratio (C) / (A) of the component (C) to the component (A) is preferably 0.01 to 100, more preferably 0. The composition for oral cavity according to any one of the above [1] to [19], which is from 0.05 to 50, more preferably from 0.2 to 10, and even more preferably from 0.2 to 5.
[21] Preferably it is a liquid oral composition, and the content of the component (D) is preferably 50% by mass or more, more preferably 60% by mass or more, and further preferably 70% by mass or more. The composition for oral cavity according to any one of the above [1] to [20], which is 95% by mass or less, preferably 90% by mass or less.
[22] It is preferably a liquid oral composition, and the mass ratio (A) / (D) of the component (A) to the component (D) is preferably 0.01 × 10 ⁻² or more, and more Preferably it is 0.012 × 10 ⁻² or more, preferably 0.8 × 10 ⁻² or less, more preferably 0.3 × 10 ⁻² or less, and further preferably 0.14 × 10 ^−2. The oral composition according to any one of [1] to [21] above.

[23] Preferably it is a dentifrice composition, the content of component (A) is 0.005 mass% or more and 1 mass% or less, and the content of component (B) is 2 mass% or more and 40 mass%. The content of the component (D) is more than 25% by mass and 70% by mass or less, and the mass ratio (B) / (A) of the component (B) to the component (A) is 5 or more and 3000 or less. And the mass ratio (A) / (D) of the component (A) to the component (D) is preferably 0.01 × 10 ⁻² or more and 3 × 10 ⁻² or less [1] to [15] 1 oral composition.
[24] Preferably it is a dentifrice composition, and the content of component (A) is 0.005% by mass or more, preferably 0.01% by mass or more, and 1% by mass or less, The oral composition according to any one of [1] to [15] and [23], which is preferably 0.8% by mass or less, and more preferably 0.5% by mass or less.
[25] Preferably it is a dentifrice composition, and the content of component (B) is 2% by mass or more, preferably 5% by mass or more, more preferably 10% by mass or more, The above [1] to [15] and [23] to [24] are preferably 15% by mass or more, 40% by mass or less, preferably 35% by mass or less, and more preferably 30% by mass or less. ] Any one composition for oral cavity.
[26] Preferably it is a dentifrice composition, and the mass ratio (B / A) of component (B) to component (A) is 5 or more, preferably 10 or more, more preferably 20 or more More preferably, it is 30 or more, preferably 3000 or less, more preferably 2000 or less, and even more preferably 1000 or less, any of the above [1] to [15] and [23] to [25] Or 1 oral composition.

[27] Preferably it is a dentifrice composition, and mass ratio (C) / (A) of component (C) and component (A) is preferably 0.01 to 100, more preferably 0.05. The composition for oral cavity according to any one of the above [1] to [15] and [23] to [26], which is ˜50, more preferably 0.05 to 10, particularly preferably 0.1 to 5. object.
[28] Preferably it is a dentifrice composition, and the content of component (D) exceeds 25% by mass, preferably 26% by mass or more, more preferably 27% by mass or more, preferably 70 The composition for oral cavity according to any one of the above [1] to [15] and [23] to [27], which is not more than mass%, more preferably not more than 60 mass%, and still more preferably not more than 50 mass%.
[29] Preferably it is a dentifrice composition, and the mass ratio (A) / (D) of component (A) and component (D) is preferably 0.01 × 10 ⁻² or more, more preferably 0.02 × 10 ⁻² or more, preferably 3 × 10 ⁻² or less, more preferably 2 × 10 ⁻² or less, and further preferably 1.5 × 10 ⁻² or less. ] The composition for oral cavity any one of [15] and [23]-[28].
[30] The composition for oral cavity according to the above [29], which is preferably a dentifrice composition, and the content of the component (E) is preferably 5% by mass or more, more preferably 7% by mass or more.

[31] The composition for oral cavity according to any one of the above [1] to [30], which is an accelerator for the amount of fluorine taken into teeth, comprising the component (A) and the component (B) as active ingredients.
[32] The composition for oral cavity according to any one of the above [1] to [30], which is used for promoting the amount of fluorine taken into a tooth.
[33] Use of the composition for oral cavity according to any one of the above [1] to [30] for promoting the amount of fluorine taken into a tooth.
[34] Use of the oral composition according to any one of the above [1] to [30] for producing an oral composition that promotes the amount of fluorine taken into a tooth.
[35] A method for promoting the amount of fluorine taken into a tooth, wherein the composition for oral cavity according to any one of [1] to [30] is applied to a tooth.

  Hereinafter, the present invention will be specifically described based on examples. In addition, unless otherwise indicated in a table | surface, content of each component shows the mass%.

Each component was mixed with content shown in Table 1, and the liquid oral cavity composition of Examples 1-11 and Comparative Examples 1-2 was prepared. Moreover, each component was mixed with content shown in Table 2, and the dentifrice composition of Examples 12-21 and Comparative Examples 3-6 was prepared. Furthermore, each component was mixed with content shown in Table 3, and the liquid oral cavity composition of Examples 22-31 and Comparative Examples 7-15 was prepared.
Next, using the obtained composition for oral cavity, the amount of fluorine uptake (μg / cm ² ) was measured according to the following method.
The results are shown in Tables 1-3.

<Measurement of fluorine uptake>
HAP pellets (APP-100 manufactured by HOYA) 10 mm × 10 mm × 2 mm were immersed in 10 mL of liquid oral compositions of Examples 1-11, 22-31 and Comparative Examples 1-2, 7-15 and left for 3 minutes. Thereafter, the composition was washed with ion exchange water to dry the pellets. Fluoride ions were extracted by immersing the dried pellet in 1 mL of 1N hydrochloric acid for 30 seconds, and neutralized by adding 2 mL of 1 mol trisodium citrate aqueous solution to the extracted hydrochloric acid. After adding 3 mL of ionic strength modifier (manufactured by TISABII Thermo Fisher Scientific) to the neutralized aqueous solution, a fluorine composite electrode (9609BNWP Thermo Fisher Scientific) is inserted and an ion analyzer (Expandable ionAnalyzer) EA 940 (manufactured by ORION)) was used to quantify the amount of fluorine extracted (μg / cm ² ). The determined amount of fluorine corresponds to the amount of fluorine adsorbed on the HAP pellet.
Moreover, the dentifrice compositions of Examples 12 to 21 and Comparative Examples 3 to 6 are the above liquid oral compositions except that 10 mm × 10 mm × 2 mm of HAP pellets (APP-100 manufactured by HOYA) were immersed in 10 g of the dentifrice composition. In the same manner as above, the amount of fluorine (μg / cm ² ) was quantified.

As shown in Tables 1 and 3, compared with Comparative Examples 1 and 7 to 13 that do not contain a sugar alcohol (B) and Comparative Examples 2, 7, and 14 to 15 that do not contain an N-acyl acidic amino acid or a salt thereof (A). And it turns out that the liquid oral cavity composition of Examples 1-11, 22-31 effectively increases the amount of fluorine taken into the teeth.
Moreover, as shown in Table 2, it contains the comparative example 3 which content of sodium chloride exceeds 3 mass%, the comparative example 4 which does not contain N-acyl acidic amino acid or its salt (A), and sugar alcohol (B). Compared with Comparative Example 5 and Comparative Example 6 with a low water (D) content, the dentifrice compositions of Examples 10 to 18 effectively increase the amount of fluorine taken into the teeth. Recognize.

Claims (7)

The following components (A) to (D):
(A) N-cocoyl glutamic acid or a salt thereof 0.005% by mass to 1% by mass (B) A sugar alcohol having a solubility in water at 20 ° C. of 40% by mass or less 2% by mass to 40% by mass (C) Fluorination One or two or more fluoride ion supply compounds selected from sodium, ammonium fluoride, potassium fluoride, and sodium fluorosiliconate 0.002% by mass to 2% by mass (D) Water exceeding 25% by mass 95% by mass or less, the content of sodium chloride is 3% by mass or less, the mass ratio (B) / (A) of the component (B) to the component (A) is 5 or more and 8000 or less, and the component ( C) / component (A) mass ratio (C) / (A) is 0.01 or more and 100 or less, and mass ratio (A) / (D) between component (A) and component (D) is 0.00. 006 × 10 ^-2 or more 4 × 10 ^-2 Not The oral composition is.   The composition for oral cavity according to claim 1, wherein the component (B) is one or more selected from erythritol, reduced palatinose, glucopyranosyl sorbitol, glucopyranosyl mannitol and mannitol. A liquid oral composition comprising:
The content of the component (A) is 0.005% by mass or more and 0.5% by mass or less,
The content of the component (B) is 2% by mass or more and 25% by mass or less,
The content of the component (D) is 50% by mass or more and 95% by mass or less,
The mass ratio (B) / (A) of the component (B) and the component (A) is 5 or more and 5000 or less, and the mass ratio (A) / (D) of the component (A) and the component (D) is 0.00. The composition for oral cavity according to claim 1, wherein the composition is 01 × 10 ⁻² or more and 0.8 × 10 ⁻² or less. A dentifrice composition comprising:
The content of the component (A) is 0.005% by mass or more and 1% by mass or less,
The content of the component (B) is 2% by mass or more and 40% by mass or less,
The content of component (D) is more than 25% by mass and 70% by mass or less,
The mass ratio (B) / (A) of the component (B) and the component (A) is 5 or more and 3000 or less, and the mass ratio (A) / (D) of the component (A) and the component (D) is 0.00. The composition for oral cavity according to claim 1, wherein the composition is 01 × 10 ⁻² or more and 3 × 10 ⁻² or less.   Furthermore, the composition for oral cavity of any one of Claims 1-4 which contains 2-20 mass% of components chosen from component (E) glycerol and propylene glycol.   The composition for oral cavity according to any one of claims 1 to 5, comprising a sugar alcohol having a solubility in water at 20 ° C of more than 40% by mass of 2% by mass to 35% by mass. The composition for oral cavity according to any one of claims 1 to 6 , which is an accelerator for the amount of fluorine uptake into teeth, comprising the component (A) and the component (B) as active ingredients.