JP6155220B2 - Aerosol insecticide - Google Patents

Description

  The present invention relates to aerosol pesticides.

  Aerosol insecticides are used to control sanitary pests such as cockroaches, flies and mosquitoes. Aerosol insecticides include spray-type insecticides that spray an arbitrary amount of contents while pressing a button, and full-volume spray-type insecticides that, after pressing a button, inject the entire amount of the contents.

As an insecticidal component, an oxadiazole-based methoxadiazone is known to exhibit an excellent effect on pyrethroid-resistant German cockroaches.
However, methoxadiazone is difficult to be formulated because it is difficult to dissolve and precipitate in general-purpose solvents (ethanol, kerosene, etc.) used for aerosol insecticides.
For such problems, an aerosol agent containing methoxadiazone and propylene carbonate has been proposed (for example, Patent Document 1). According to the invention of Patent Document 1, an aerosol insecticide in which methoxadiazone is well dissolved can be obtained.

Japanese Patent No. 2959995

However, the invention of Patent Document 1 requires the use of dimethyl ether (DME), which is highly compatible with propylene carbonate, as a propellant, and the type of propellant is limited. Since DME is difficult to adjust the injection pressure, it has been difficult to reduce the size of aerosol insecticides. There is liquefied petroleum gas (LPG) as a propellant that can easily adjust the injection pressure of the preparation, but methoxadiazone is difficult to dissolve in LPG. In addition, LPG has poor compatibility with propylene carbonate. For this reason, when LPG was used as a propellant in an aerosol insecticide containing methoxadiazone as an insecticidal component, methoxadiazone was precipitated or propylene carbonate separated from LPG, and methoxadiazone could not be jetted well.
Therefore, an object of the present invention is to provide an aerosol insecticide in which LPG is used as a propellant and methoxadiazone can be jetted well.

The aerosol insecticide of the present invention contains 0.5% by mass or more of methoxadiazone (A), propylene carbonate (B), monohydric alcohol (C) having 1 to 5 carbon atoms, and liquefied petroleum gas (D). The mass ratio represented by the component (B) / the component (A) is 1.0 or more, the mass ratio represented by the component (C) / the component (B) is 2.0 or more, and The mass ratio represented by the component (D) / {the component (B) + the component (C)} is 0.5 to 2.0.
It is preferable not to contain dimethyl ether, and it is preferable that it is a total injection type.

  According to the aerosol insecticide of the present invention, methoxadiazone can be jetted satisfactorily even though LPG is used as a propellant.

The aerosol insecticide of the present invention comprises methoxadiazone (A) (component (A)), propylene carbonate (B) (component (B)), and C1-C5 monohydric alcohol (C) (component (C). ) And liquefied petroleum gas (D) (component (D)).
The aerosol insecticide is a liquid and may be enclosed in a container such as a spray can and used as a spray-type insecticide or may be used as a full-injection-type insecticide.

((A) component)
The component (A) is methoxadiazone (5-methoxy-3- (2-methoxyphenyl) -1,3,4-oxadiazol-2 (3H) -one).
The component (A) is an insecticidal component that exterminates insects such as flies, mosquitoes and cockroaches. Among them, an excellent insecticidal effect is exhibited against cockroaches, particularly pyrethroid resistant cockroaches.

  The content of the component (A) in the aerosol insecticide is 0.5% by mass or more, preferably 0.5 to 15.0% by mass, more preferably 1.0 to 10.0% by mass. 5-10.0 mass% is further more preferable, and 3.0-10.0 mass% is especially preferable. If it is less than the lower limit, the insecticidal effect cannot be exhibited. If it exceeds the upper limit, the component (A) tends to precipitate.

((B) component)
The component (B) is propylene carbonate. The aerosol insecticide can prevent precipitation of the component (A) by containing the component (B).

  For example, the content of the component (B) in the aerosol insecticide is preferably 4 to 20% by mass, and more preferably 5 to 15% by mass. If it is less than the said lower limit, there exists a possibility that (A) component may precipitate. If the value exceeds the upper limit, the component (B) and the component (D) may be separated.

((C) component)
(C) A component is a C1-C5 monohydric alcohol. By containing the component (C), the aerosol pesticide can prevent the component (B) and the component (D) from separating.
Examples of the component (C) include methanol; ethanol; 1-propanol, 2-propanol; butanol such as 1-butanol and 2-methyl-1-propanol; and pentanol such as 1-pentanol. , Methanol, ethanol and propanol are preferable, and ethanol is more preferable. By using these components (C), the compatibility between the components (B) and (D) can be increased.

  20-60 mass% is preferable, for example, and, as for content of (C) component in an aerosol insecticide, 30-50 mass% is more preferable. If it is less than the said lower limit, there exists a possibility that (B) component and (D) component may become easy to isolate | separate. If the above upper limit is exceeded, when the aerosol insecticide is sprayed, there is a possibility that the droplet diameter becomes large and difficult to diffuse.

((D) component)
Component (D) is liquefied petroleum gas (LPG). The component (D) mainly functions as a propellant. Since the vapor pressure of component (D) can be controlled, the internal pressure of the container in which the aerosol insecticide is enclosed can be changed, and the aerosol insecticide can be injected at various injection pressures. Therefore, by using the component (D) as a propellant, it is appropriate according to the difference in product form such as spray type, full quantity injection type, etc., the size of the space to be treated in the full quantity injection type aerosol insecticide, etc. Can be adjusted to an appropriate injection pressure.
In general, the component (D) contains propane, butane or the like as a main component, but the composition of the component (D) is not particularly limited in the present invention.

  The content of the component (D) in the aerosol insecticide is determined in consideration of the particle diameter of the droplet of the desired aerosol insecticide, for example, preferably 20 to 65% by mass, more preferably 30 to 60% by mass. preferable. If it is less than the said lower limit, when an aerosol insecticide is injected, there exists a possibility that a droplet diameter may become large and it may become difficult to spread | diffuse. If it exceeds the upper limit, the component (B) and the component (D) may be easily separated.

In the aerosol insecticide, the mass ratio represented by component (B) / component (A) (hereinafter sometimes referred to as B / A ratio) is 1.0 or more, and preferably 1.5 or more. If it is less than the said lower limit, (A) component will precipitate easily.
Although the upper limit of B / A ratio is not specifically limited, For example, 30.0 or less is preferable and 20.0 or less is more preferable. If it exceeds the upper limit, the content of the component (A) is too small, and the insecticidal effect may be reduced.

In the aerosol preparation, the mass ratio represented by component (C) / component (B) (hereinafter sometimes referred to as C / B ratio) is 2.0 or more, and preferably 3.5 or more. If it is less than the said lower limit, (B) component and (D) component will be easy to isolate | separate.
Although the upper limit of C / B ratio is not specifically limited, For example, 15.0 or less is preferable and 10.0 or less is more preferable. If it exceeds the above upper limit, the content of the component (B) becomes too small and the component (A) may be precipitated.

  In the aerosol preparation, the mass ratio represented by (D) component / {(B) component + (C) component} (hereinafter sometimes referred to as D / (B + C) ratio) is 0.5 to 2.0. Yes, 1.0 to 2.0 is preferable. When the D / (B + C) ratio is less than the above lower limit, the component (D) is too small, and when the aerosol insecticide is sprayed, the droplet diameter becomes large and the diffusion becomes difficult. If it exceeds the upper limit, the component (D) becomes too much, and the component (B) and the component (D) are separated.

(Optional component)
The aerosol insecticide may contain an optional component other than the components (A) to (D) as long as the effects of the present invention are not impaired. As optional components, insecticide components (arbitrary insecticide components) other than component (A), solvents (arbitrary solvents) other than components (B) to (C), propellants other than component (D) (arbitrary propellants), stable Agents, rust inhibitors, emulsifiers, dispersants, excipients, pigments, fragrances and the like.

  Examples of the optional insecticide include pyrethroid compounds such as permethrin, phenothrin and ciphenothrin, insecticidal active ingredients such as neonicotinoids and organic phosphorus compounds, and insect growth inhibitors.

  Optional solvents include acetone, glycol ethers (ethylene glycol and derivatives thereof, diethylene glycol and derivatives thereof, other alkylene glycols and derivatives thereof), dimethyl carbonate, N-methylpyrrolidone, N-ethylpyrrolidone, γ-butyrolactone, lactic acid Examples include methyl, ethyl lactate, dibutyl lactate, isoparaffin, normal paraffin, kerosene, isopropyl myristate, and water.

Examples of the optional propellant include dimethyl ether (DME), chlorofluorocarbon, hydrochlorofluorocarbon, hydrofluorocarbon, hydrofluoroolefin, compressed gas (carbon dioxide gas, nitrogen gas, nitrous oxide gas, etc.) and the like. However, in order to enhance the effect of the present invention, it is preferable that an arbitrary propellant (particularly DME) is not substantially contained.
“Substantially not contained” means that it is not contained at all or contained to such an extent that the effect of the present invention is not affected. For example, the content is 5 parts by mass or less with respect to 100 parts by mass of component (D) The amount is applicable.

(Production method)
Aerosol insecticide is manufactured according to a conventionally well-known manufacturing method. For example, (A)-(C) component and arbitrary components as needed are mixed and it is set as a chemical | medical solution, The method of filling this chemical | medical solution and (D) component in a container to make an aerosol insecticide is mentioned.
The filling amount of the aerosol insecticide in the container is determined in consideration of the product form and the like.
For example, in the case of the full-quantity injection method, it is determined as appropriate according to the size of the space to be processed, and for example, the amount of component (A) is 1.5 to 250 mg per 1 m ³ of the space to be processed .

The pressure in the container filled with the aerosol insecticide is determined according to the product form of the aerosol insecticide, for example, 0.1 to 0.5 MPa if it is a spray type, 0.1 to 0.5 MPa.
In addition, in the full-quantity jetting method, when the insects are to be controlled, it is preferable that the internal pressure in the container is 0.15 to 0.35 MPa so that the diffused droplets are dropped in a short time.
The pressure in the container is adjusted by, for example, the composition of LPG (mass ratio represented by butane / propane (hereinafter sometimes referred to as B / P ratio)).
For example, by setting the B / P ratio to 100/0 to 70/30, it can be adjusted to an arbitrary internal pressure in the range of 0.20 to 0.40 MPa (25 ° C.).

(how to use)
Aerosol insecticides are used in a way that depends on the product form. If it is a spray type, an aerosol pesticide is sprayed on the target to be controlled. If it is a full-quantity injection type, it is installed in a sealed room and the entire content is injected.
The target of extermination is not particularly limited. Cockroaches such as German cockroaches, black cockroaches, Japanese cockroaches, American cockroaches, flying cockroaches, etc .; Dust mites; horn mites, such as house ticks; animal parasitic ticks, such as house dust mites, flea mites; fleas, such as cat fleas, human fleas, dog fleas; Lice; bed bugs; moths; high insecticidal effects against clothing pests such as moths, moths and cutworms, and their practicality is extremely high.

As described above, since the aerosol insecticide of the present invention has the components (A) to (D), the component (A) is dissolved well without being precipitated, and the component (B) and ( D) Component does not separate. For this reason, component (A) can be jetted and diffused well by component (D).
The aerosol insecticide of the present invention can change the injection pressure by adjusting the pressure in the container. Therefore, the product can be further reduced in size, can be set to an injection pressure according to the size of the space to be treated, and can be injected in a state suitable for the removal target. is there.

  EXAMPLES Hereinafter, although an Example is shown and this invention is demonstrated in detail, this invention is not limited by the following description.

(Raw materials used)
Component (A): Metoxadiazone (trade name “Elemic”, manufactured by Sumitomo Chemical Co., Ltd.).
(B) component: Propylene carbonate.
Component (C): absolute ethanol.
(D) Component: LPG.
(D ′) Component: DME.

(Evaluation method)
<Insecticidal effect>
Sealed test chamber floor three locations 32m ³ (the chamber center, the room corner intermediate point between the center and corners) Place the reluctance dish, each dish, sensitive German cockroaches 10 animals (the respective five male and five female) test I put it as an insect.
The aerosol spray insecticide of the total amount injection type in each case was placed in the center of the floor surface of the test room, the aerosol insecticide was sprayed by pressing a button, and left in a sealed state for 1 hour. Thereafter, the test chamber was opened and the test insects were collected. About the collected test insects, the number of knockdowns and the number of lethalities immediately after opening were measured in a separate room, and the effective rate (%) immediately after opening was calculated according to the following formula (1).

  Effective rate (%) = (number of knockdowns + lethality) ÷ 30 animals x 100 (1)

  The obtained effective rate was classified into the following criteria, and the insecticidal effect was evaluated. Those having an evaluation of “◎” or “◯” were evaluated as having good insecticidal effect.

[Criteria]
A: Effective rate is 90% or more.
○: Effective rate is 70% or more and less than 90%.
X: Effective rate is less than 70%.

<Solubility>
The aerosol insecticide of each example was visually observed under an environment of 25 ° C., and the solubility was evaluated according to the following criteria. This test is for evaluating whether or not the component (A) is sufficiently dissolved, and “◎” or “◯” was evaluated as having good solubility. If the solubility is “◎” or “◯”, it can be evaluated that the aerosol insecticide can be easily produced and that the blended methoxadiazone can be injected without remaining.

[Criteria]
(Double-circle): Precipitation is not recognized but it is clear.
○: At first glance, it is difficult to understand, but slight precipitation is observed when looking closely.
X: Precipitation is observed at first glance.

<Compatibility>
The aerosol insecticide of each example was visually observed under an environment of 25 ° C., and the solubility was evaluated according to the following criteria. This test is for evaluating whether or not the components (B) to (D) are compatible with each other, and “◎” or “◯” is evaluated as having good compatibility. If the compatibility is “◎” or “○”, it can be evaluated that the blended methoxadiazone can be injected without remaining.
[Criteria]
(Double-circle): Separation of a liquid is not recognized.
○: At first glance it is difficult to understand, but if you look closely, liquid is slightly separated.
X: At first glance, it can be seen that the liquid is separated.

<Diffusion>
Since the diffusivity of the aerosol insecticide correlates with the particle diameter of the sprayed aerosol insecticide droplet, the diffusivity was evaluated using the particle diameter as an index.
Aerosol pesticide of the total amount injection type was sprayed, and the particle size of the sprayed aerosol insecticide droplets was measured. The particle diameter is a 50% volume distribution particle diameter measured using a particle size distribution measuring apparatus using a laser light scattering method. The obtained volume distribution 50% particle size was classified into the following evaluation criteria, and diffusivity was evaluated. When the 50% volume distribution particle diameter was less than 70 μm, it was evaluated that the diffusibility was excellent. If the diffusivity is “◎” or “◯”, it can be evaluated that methoxadiazone can diffuse over a wide range.

[Criteria]
A: Volume distribution 50% Particle diameter is less than 50 μm.
○: Volume distribution 50% Particle diameter is 50 μm or more and less than 70 μm.
X: Volume distribution 50% The particle diameter is 70 μm or more.

<Internal pressure>
About the aerosol injection insecticide of the whole quantity injection type of each case, the pressure (25 degreeC) in a pressure-resistant container was measured with the pressure gauge.

(Examples 1-1 to 1-12, Comparative Examples 1-1 to 1-8)
According to the composition of Tables 1-2, (A)-(C) component was mixed and it was set as the chemical | medical solution. According to the composition of Tables 1-2, the chemical | medical solution and (D) component were filled in the container of "fog balsan" (brand name, Lion Corporation make), and the aerosol injection insecticide of the whole quantity injection was obtained. The filling amount of the aerosol insecticide is as described in the table.
Specifically, the chemical solution is put into a pressure-resistant container, and the component (D) (B / P ratio = 95/5) is filled and sealed, and an injection device is attached to obtain a full-injection aerosol insecticide. It was. About the obtained aerosol insecticide, insecticidal effect, solubility, compatibility, diffusibility and internal pressure were evaluated, and the results are shown in the table.

As shown in Tables 1-2, in Examples 1-1 to 1-12 to which the present invention was applied, all of the insecticidal effect, solubility, compatibility, and diffusivity were “◎” or “◯”. .
In addition, in Examples 1-1 to 1-12, the internal pressure could be 0.25 MPa. Thereby, in Examples 1-1 to 1-12, the injection pressure is reduced, and the ejected liquid droplets quickly drop.
On the other hand, in Comparative Example 1-1 in which the content of the component (A) is 0.2% by mass, the insecticidal effect was “x”.
Comparative Examples 1-2 to 1-3 in which the B / A ratio is less than 1.0 are Comparative Examples 1-4 to 1-5 in which the solubility is “x” and the C / B ratio is less than 2.0. The compatibility was “x”. Comparative Examples 1-6 to 1-7 in which the D / (B + C) ratio is less than 0.5 are Comparative Examples 1-8 in which the diffusibility is “x” and the D / (B + C) ratio is more than 2.0. The compatibility was “x”.
From the above results, it was confirmed that by applying the present invention, LPG was used as a propellant and methoxadiazone could be injected well.

(Examples 2-1 to 2-4, Comparative Example 2-1)
Except for obeying the composition shown in Table 3, a full spray aerosol pesticide was obtained in the same manner as in Example 1-1. About the obtained aerosol insecticide, internal pressure was evaluated and the result is shown in the table. The D / (B + C) ratio in Comparative Example 2-1 is a value obtained by regarding the (D ′) component as the (D) component.

  As shown in Table 3, Examples 2-1 to 2-4 using LPG as a propellant could be adjusted to various internal pressures by changing the composition of LPG.

Claims (3)

Containing methoxadiazone (A) 0.5 mass% or more, propylene carbonate (B), ethanol (C), and liquefied petroleum gas (D),
The mass ratio represented by the component (B) / component (A) is 1.0 or more, the mass ratio represented by the component (C) / component (B) is 2.0 or more, and ( Aerosol insecticide whose mass ratio represented by D) component / {the said (B) component + the said (C) component} is 0.5-2.0.
  The aerosol pesticide of claim 1, which does not contain dimethyl ether.   The aerosol insecticide of Claim 1 or 2 which is a whole quantity injection type.