JP6182015B2 - Reproductive performance improver for livestock - Google Patents

Description

  The present invention relates to a livestock reproductive performance improving agent and the like. More specifically, the present invention relates to a preparation and method for improving and improving the reproductive performance represented by the conception rate, pregnancy rate, days of emptying, and delivery interval of livestock.

  In the dairy industry that uses livestock, it is important not only to improve the quantity and quality of livestock products (milk, meat, etc.) but also how to stably and efficiently breed them. . However, for example, in dairy cows, while the annual milk yield per cow improves, its reproductive performance tends to decrease year by year. The case where it is causing is seen.

  In recent years, the time at which estrus returns after delivery has been delayed, and weakening of estrus has been observed. , Leading to extended delivery intervals. For these reasons, improving and improving the reproductive performance of livestock is an important issue in livestock management, and there is a great demand in the industry for new ingredients and methods for improving and improving the reproductive performance.

  In addition, as a method for improving the reproduction performance of livestock, the melting point is −60 to 40 ° C., the iodine value is in the range of 30 to 470, and the carbon number is 12 to 24 having 2 to 6 double bonds in the molecule. A method of feeding a feed containing a metal salt of a fatty acid in an amount of 20 to 200 g per head per day in terms of the above fatty acid at least from 30 days before parturition to conception by postpartum artificial insemination (Patent Document 1) A method of improving the vitality of sperm by feeding γ-linolenic acid to a bull and seeding a cow using the sperm is known (Patent Document 2). However, there is a continuing need in the industry for the development of further oral administration / feeding ingredients that can improve and improve the reproductive performance of livestock simply and efficiently.

On the other hand, trehalose is a naturally occurring disaccharide that is also contained in microorganisms and insects, and is a technology in which two α-glucose molecules are linked by 1-1 glycoside, and a high-purity trehalose is produced in large quantities at low cost. Has also been developed (Patent Document 3).
Trehalose is a very stable substance and is known to have various functions such as resistance to freezing, suppression of discoloration, suppression of starch and protein denaturation, and is used in a wide range of fields such as food and cosmetics.

Regarding the effects of trehalose on livestock such as cattle, it is known that trehalose is fed to beef cattle (fattening cattle) to improve the meat color and reduce the drip amount and improve the meat quality of the cow ( Patent Document 4). In addition, the effects of promoting the growth of livestock and pets by feeding trehalose, improving fecal properties, and improving meat quality (color and gloss) of livestock and poultry are also known (Patent Document 5). Furthermore, it is known that milk is increased by feeding trehalose to mammals such as cattle, goats, and sheep, and the calcium concentration in the milk is further stabilized (Patent Document 6).
However, it has not been known so far to improve or improve the reproductive performance of livestock by oral administration or feeding of trehalose.

JP 2008-125377 A JP 2013-032288 A JP-A-9-009986 JP 2007-097409 A JP 2008-019236 A JP 2007-319156 A

  The present invention relates to a preparation and method using a highly safe active ingredient capable of improving and improving reproductive performance such as conception rate and pregnancy rate of livestock, and exhibiting sufficient effects by oral administration or feeding. It was made for the purpose of providing.

  In order to achieve the above object, as a result of intensive studies, the present inventors studied the effect of oral administration or feeding of trehalose on the reproductive performance of livestock, and the conception rate was obtained by oral administration or feeding of trehalose to domestic animals. The present inventors have found that the pregnancy rate and the like can be improved, and the number of days of pregnancy and the delivery interval can be shortened. As a result of further research based on these useful new findings, the present invention which is a livestock reproductive performance improving agent and the like containing trehalose as an active ingredient has been completed.

That is, the embodiment of the present invention is as follows.
(1) A livestock reproductive performance improving agent (reproduction performance improving agent) characterized by containing trehalose as an active ingredient.
(2) The agent according to (1), wherein the reproductive performance is improved by at least one or more selected from the conception rate improvement, the pregnancy rate improvement, the number of days of emptying, and the delivery interval.
(3) The agent according to (1) or (2), wherein trehalose at 0.05 to 0.42 g / kg body weight per day is orally administered to livestock.
(4) The agent according to any one of (1) to (3), wherein the livestock is at least one selected from cattle, pigs, sheep, horses and goats.

(5) A method for improving the reproductive performance of livestock (method for improving reproductive performance), characterized by orally administering or feeding trehalose to livestock.
(6) The method according to (5), wherein the reproductive performance improvement is at least one or more selected from the conception rate improvement, pregnancy rate improvement, shortening the number of days of free pregnancy, and delivery interval.
(7) The method according to (5) or (6), wherein trehalose at 0.05 to 0.42 g / kg body weight per day is orally administered or fed to livestock.
(8) The method according to any one of (5) to (7), wherein the livestock is at least one selected from cattle, pigs, sheep, horses and goats.

  According to the present invention, just by oral administration or feeding of trehalose to livestock, it is possible to improve the conception rate, pregnancy rate, etc., and to shorten the number of days of emptying, the delivery interval, etc. Reproductive performance can be improved and improved, and livestock productivity and livestock management can be stabilized.

  Hereinafter, the present invention will be described in detail.

  In the present invention, trehalose (at least one selected from α, α-trehalose, α, β-trehalose, β, β-trehalose) is used as an active ingredient such as a livestock reproductive performance improving agent. As for trehalose, not only a pure product (purified product) can be used, but also a crude product (pasted product, diluted product, emulsion, suspension, etc.) can be used. In addition, it is possible to use a granulated product by adding an excipient such as starch or dextrin, or a tableted product. Furthermore, what was coated with fats and oils etc. (by-passing) so that it may not be decomposed | disassembled by a lumen can be used. Trehalose is relatively difficult to be broken down by rumen, so there is basically no problem even if it is administered without such processing.

  The trehalose can be used as an active ingredient as it is as a feed additive, feed, feed composition, animal medicine, promoter (enhancement agent), and other agents. Moreover, it is also possible to provide feed additives, feeds, feed compositions by adding and mixing commonly used feed ingredients, and also to provide animal pharmaceutical preparations containing trehalose as an active ingredient. it can. In this case, it may be formulated according to a conventional method of animal pharmaceutical preparation, and other active ingredients having other physiological functions can be used in combination.

  The preparation is orally administered in various forms, and examples of the administration form include oral administration by tablets, capsules, granules, powders, syrups and the like. These various preparations are usually used in the field of veterinary pharmaceutical formulation techniques such as excipients, binders, disintegrants, lubricants, flavoring agents, solubilizers, suspension agents, coating agents, etc. It can be formulated with known adjuvants. It is also possible to use a pure trehalose product (powder, crystal, etc.) as it is as a preparation.

  In addition, what was formulated in this way can be used as a feed composition, and can be fed directly to livestock as a feed, or used as a feed additive in other feed ingredients. It is also possible to add and mix them.

  In the present invention, animals that are orally administered or fed with trehalose are domestic animals that are mammals. In particular, livestock whose milk and / or meat is edible is shown as a preferred example, such as dairy cows (especially Holstein and Jersey), beef cattle, pigs, sheep, etc., but not limited thereto is not. Other examples include horses and goats.

The oral administration or feed amount of trehalose to livestock is preferably about 0.05 to 0.42 g / day per kg of animal body weight, and more preferably about 0.08 to 0.17 g / day per kg body weight of animal. For example, taking a dairy cow (body weight of about 500 to 1000 kg) as an example, 25 to 420 g / head, preferably 40 to 170 g / head per day is shown as a suitable oral administration or feed amount. And it is preferable that oral administration or salary is performed continuously every day during a required period.
In other domestic animals, the oral administration or the amount of feeding may be set in consideration of the body weight and the like, but the oral administration or the amount of feeding other than the above including dairy cows is not completely excluded.

  The present invention has a great feature in that the effectiveness (functionality) of trehalose is directly confirmed by using live animals at actual production sites. Specifically, trehalose is orally administered to lactating Holstein dairy cows, and the reproductive performance of the herd is statistically analyzed before and after administration, and the physiological action is extremely characteristic. It can be said.

  And this invention discovered for the first time that trehalose has the new use of improving or improving the reproduction performance by oral administration or feeding to livestock, that is, the present invention is the reproduction performance of livestock. It can also be said that it is a novel use invention of trehalose as an improving agent.

  Examples of the present invention will be described below, but the present invention is not limited to these examples, and various modifications can be made within the technical idea of the present invention.

  In order to investigate the effect of oral administration or feeding of trehalose on the reproductive performance of dairy cows, the following test was conducted.

When 100 Holstein dairy cows (cow) were not administered trehalose (control group: 1 year) and when trehalose was administered at 100 g / day per head (body weight: about 600 kg) (trehalose group: 1 year) And comparison of reproductive performance (conception rate, pregnancy rate, number of empty days, parturition interval).
The salary menu for each period is shown in Table 1 below.

The set milk amount slightly increases and decreases during the period, and the component values of the TMR feed are as follows.
Crude protein 16-17%
RDP (Rumen degradation protein) 36%
RUP (Rumen non-degradable protein) 34%
NDF (total fiber) 40%
NFC (non-fibrous carbohydrates) 34%
Starch 17%

  The results are shown in Table 2 below. As a result, a significant improvement in conception rate and pregnancy rate was observed in the trehalose group as compared with the control group, and the number of days of free pregnancy and the delivery interval were also significantly shortened. Therefore, it was revealed that the reproductive performance was significantly improved and improved by trehalose administration to dairy cows.

  The present invention is summarized as follows.

  That is, the present invention is capable of improving and improving the reproductive performance such as conception rate and pregnancy rate of domestic animals (dairy cows, beef cattle, pigs, etc.), and exhibits sufficient effects by oral administration or feeding. An object of the present invention is to provide a preparation, method and the like using an active ingredient having a high concentration.

  In addition, trehalose is orally administered or fed to livestock (dairy cows, beef cattle, pigs, etc.) to improve the conception rate, pregnancy rate, etc. The breeding result can be improved and improved easily and effectively.

Claims (8)

A feed composition for improving the reproductive performance of livestock, comprising trehalose as an active ingredient. The composition according to claim 1, wherein the reproductive performance improvement is at least one or more selected from an improvement in conception rate, improvement in pregnancy rate, shortening of the days of free pregnancy, and shortening of the delivery interval. Domestic animals, it 0.05~0.42g / kg body weight of trehalose per day is used as salary, composition according to claim 1 or 2, characterized in. The composition according to any one of claims 1 to 3, wherein the livestock is at least one selected from cattle, pigs, sheep, horses and goats.   A method for improving the reproductive performance of livestock, comprising orally administering or feeding trehalose to livestock.   6. The method according to claim 5, wherein the reproductive performance improvement is at least one or more selected from an improvement in conception rate, an improvement in pregnancy rate, a reduction in the number of days of free pregnancy, and a reduction in the delivery interval.   The method according to claim 5 or 6, wherein 0.05 to 0.42 g / kg body weight of trehalose is orally administered or fed to livestock.   The method according to any one of claims 5 to 7, wherein the livestock is at least one selected from cattle, pigs, sheep, horses and goats.