JP6234068B2 - Skin patch - Google Patents

Description

  The present invention relates to a skin external patch comprising a water-soluble polymer sheet, which is used as a skin external preparation such as cosmetics.

As cosmetic and pharmaceutical dosage forms, patches such as packs have been developed for the purpose of retaining active ingredients in the composition on the skin or delivering them to the dermis.
Conventionally, such a patch is generally one in which a gel or the like is coated on the surface of a support (base material) made of a nonwoven fabric or the like. Most of such patches are applied to the skin as an integral part of the gel and the support, and are used after being peeled off after a certain period of time.

  In recent years, as a new patch form, for example, a water-soluble film holding an active ingredient is formed on the surface of a base material made of a synthetic resin film, and this is attached to the skin, and then water is added to After the film is dissolved and then the synthetic resin film is peeled off, a water-soluble film holding the active ingredient is formed on the surface of the substrate made of water gel, and this is applied to the skin. The thing of the form etc. which peel a water gel after a water-soluble film melt | dissolves by the water | moisture content transfer of this is developed (patent document 1).

  Further, as a patch form that does not require a support (base material), a water-soluble polymer formed from a composition containing one or more natural polymers selected from the group consisting of chitosan, fish-derived collagen and sericin A sheet-like cosmetic comprising a sheet and utilizing functions such as dissolving the water-soluble polymer sheet with water and attaching the water-soluble polymer to the skin to improve skin smoothness is known (Patent Document) 2).

JP 2009-221391 A JP 2008-69119 A

The water-soluble polymer sheet described in Patent Document 2 does not use a support when applied to the skin, but dissolves on the skin surface. There is an advantage that it is easy to adhere to the skin and that the active ingredient can be efficiently transferred to the skin and delivered to the dermis.
However, such a water-soluble polymer sheet has a problem that it is not easy to handle when it is attached to a target portion of the skin.
Specifically, when trying to stick the water-soluble polymer sheet to a part of the target face and handling it by hand, the water-soluble polymer sheet is twisted or curled, and the sheets are There are problems such as adhesion and collapse of the sheet shape.
Such a problem is particularly serious in providing a patch of a type that does not require a support (base material) when applied to the skin.
Also, when a water-soluble polymer sheet is stored in a storage bag (for example, made of an aluminum vapor deposition film), the water-soluble polymer sheet sticks to the inner surface of the storage bag and cannot be taken out from the storage bag. There is.

  In addition, when water is added after being applied to the skin, the water-soluble polymer sheet dissolves on the skin, and when trying to provide a patch in which the sheet components spread on the skin, the solubility of the sheet should be improved. Then, the sheet must be thinned, and the above-mentioned difficulty in handling, in particular, the adhesion between the sheets and the collapse of the shape due to the twisting or curling become remarkable.

  Actually, as described in Patent Document 2, although a patch of a type that does not require a support (base material) has been proposed, various problems regarding the handling properties as described above have not been solved. Therefore, the current situation is not sufficiently practical.

  Then, this invention makes it a subject to provide the technique which improves the handleability of the external skin patch which contains a water-soluble polymer sheet in a structure. In particular, an object of the present invention is to provide a technique for improving the handleability of an external skin patch that can be attached to the skin without a support (base material).

The present inventor has found that a water-soluble polymer sheet containing a water-soluble polymer mainly composed of pullulan and having a water content of 10% by weight or less is hardly twisted or curled and has a very high handleability. I found it.
Further, the present inventor has found that the water-soluble polymer sheet is free from inconveniences such as the sheet surface adhering to the container surface and difficult to take out even when stored in a container such as a storage bag.
Further, the present inventor has found that the water-soluble polymer sheet can be easily dissolved by adding water after being attached to the skin, and can be thinly stretched on the skin.
The present inventor has completed the following invention based on these findings.

The present invention for solving the above-mentioned problems is an external skin patch comprising a water-soluble polymer sheet, which is used without a support, and the water-soluble polymer sheet comprises a water-soluble polymer mainly composed of pullulan. And a water content of the water-soluble polymer sheet is 10% by weight or less.
As the water-soluble polymer constituting the water-soluble polymer sheet, pullulan is mainly used, and the water content of the water-soluble polymer sheet is 10% by weight or less, so that the water-soluble polymer sheet is twisted or rounded. Can be prevented, and the handleability of the water-soluble polymer sheet can be improved.

  In a preferred form of the water-soluble polymer, pullulan is 50% by weight or more of the total amount of the water-soluble polymer. By setting it as such a composition, the handleability of the said water-soluble polymer sheet and the solubility to water improve.

  The water-soluble polymer may further contain a water-soluble polymer usually used as a cosmetic ingredient in addition to pullulan. Preferred examples of the water-soluble polymer usually used as the cosmetic ingredient include xanthan gum, carboxymethyl cellulose, and carrageenan. In this case, in a preferred form of the water-soluble polymer, the weight ratio of pullulan to one or more selected from the group consisting of xanthan gum, carboxymethyl cellulose, and carrageenan is 1: 1 to 30: 1. . By setting the water-soluble polymer to such a composition, the handleability and solubility in water of the water-soluble polymer sheet are improved.

The water-soluble polymer sheet may contain a polyhydric alcohol as a humectant.
By containing a polyhydric alcohol in the water-soluble polymer sheet, the water-soluble polymer sheet can be prevented from warping.

The water-soluble polymer sheet may contain oil. The oil content in this case is preferably 0 to 35% by weight. The oil is not particularly limited as long as it is used for cosmetics.
By containing oil in the polymer sheet, wrinkles can be prevented from occurring in the water-soluble polymer sheet.

  The external skin patch of the present invention can be dissolved and spread thinly on the skin by adding water after being applied to the target site of the skin.

In a preferred embodiment of the present invention, at least one surface of the water-soluble polymer sheet is coated with a peelable sealing material. In a preferred form of the sealing material, a weak adhesive is applied to the contact surface with the water-soluble polymer sheet.
By covering at least one surface of the water-soluble polymer sheet with a peelable sealing material, the strength of the water-soluble polymer sheet is increased, and it is easy to store and store.

  Moreover, it is preferable that the sealing material is provided with a slit for dividing the sealing material. By providing the slit, the water-soluble polymer sheet and the sealing material can be easily peeled off.

The present invention that solves the above-described problems involves applying a composition for external use on skin containing 0.1 to 10% by weight of a water-soluble polymer mainly composed of pullulan and 70 to 99% by weight of water onto a resin film. A sheet forming process of drying the coated skin external composition until the water content is 10% by weight or less to form a water-soluble polymer sheet on the resin film, This is a method for producing an external skin patch.
According to such a production method, an external skin patch having excellent handleability can be easily produced.

  In the above production method, preferably, the external composition for skin is 0.1 to 10% by weight of pullulan, and one or more selected from the group consisting of xanthan gum, carboxymethylcellulose, and carrageenan. Includes weight percent.

  In the above production method, preferably, the external composition for skin contains 0 to 10% by weight of a humectant selected from polyhydric alcohols and 0 to 5% by weight of oil.

In the above manufacturing method, preferably, after the sheet forming process, the surface opposite to the resin film contact surface of the water-soluble polymer sheet is coated with a peelable sealing material, and a sealing process, A cutting step of cutting the coated water-soluble polymer sheet into a predetermined shape.
According to this production method, an external skin patch comprising a water-soluble polymer sheet coated with a sealing material can be easily produced.

  The sealing material is preferably coated with a weak adhesive. By covering the surface of the sealing material on which the weak adhesive is applied to the surface opposite to the resin film contact surface of the water-soluble polymer sheet, the water-soluble polymer sheet can be easily coated. Can do.

The skin external patch of the present invention is less likely to be twisted or curled and has excellent handleability. Further, in a preferred form of the external skin patch of the present invention, it can be applied to the intended skin portion, and when water is added, it can be easily dissolved in water and spread thinly on the skin.
That is, in a preferred form, the external skin patch of the present invention is applied to the target skin part and easily dissolved by adding a small amount of water, but it causes warping and curling before application. It is not very practical.
Moreover, even when the skin external patch of the present invention is housed in a container such as a storage bag, for example, it is difficult to stick to the inner surface of the container and can be easily taken out during use.
In addition, the external skin patch of the present invention has a small degree of deformation such as elongation or shrinkage of the water-soluble polymer sheet during storage, and is excellent in shape stability.

By the way, the present inventor is a skin external patch comprising a water-soluble polymer sheet, and the surface of the water-soluble polymer sheet is wet with a liquid composition having an IOB value of 0.8 to 3.2. Developed an external skin patch that does not require a support, and has filed a patent application separately. Such an external skin patch may be slightly uncomfortable when used because the surface of the sheet is wet.
The external skin patch of the present invention is less likely to cause warping or curling of the water-soluble polymer sheet without wetting the surface of the water-soluble polymer sheet with a liquid composition as in the above-described invention, and is excellent in handleability and uncomfortable during use I won't let you.

  Moreover, according to the manufacturing method of the external skin patch of this invention, the external skin patch excellent in the handleability as mentioned above can be manufactured easily.

It is a top view of the skin external patch of this invention. It is sectional drawing along the AA line of the skin external patch shown in FIG. It is a schematic process drawing of the manufacturing method of the external skin patch of this invention. The BB line shown in FIG. 3A is omitted in FIGS. 3B to 3E. It is sectional drawing along the BB line of FIG.

The external skin patch of the present invention will be described with reference to FIGS.
The skin external patch 1 comprises a water-soluble polymer sheet 2 and a sealing material 3 covering one surface thereof.

  The water-soluble polymer sheet 2 constituting the external skin patch 1 is a sheet having a property that the water-soluble polymer network is destroyed by the presence of water. In the present invention, the “sheet” means a shape that is flat enough to be attached to the skin and is flexible.

  The water-soluble polymer sheet 2 contains a water-soluble polymer. The water-soluble polymer content in the water-soluble polymer sheet 2 is preferably 15 to 99% by weight. The water-soluble polymer has a function of retaining other components in the network and maintaining the sheet shape.

The water-soluble polymer constituting the water-soluble polymer sheet 2 is mainly composed of pullulan. Here, “mainly” means that the proportion of pullulan in the water-soluble polymer is the largest. The content of pullulan in the water-soluble polymer is preferably 50% by weight or more, more preferably 50 to 95% by weight, and more preferably 50 to 80% by weight.
In addition, pullulan can be combined with other water-soluble polymers that can be used as cosmetic ingredients. Examples of such water-soluble polymers include carrageenan, xanthan gum, carboxymethylcellulose, methylhydroxypropylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, sodium alginate, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, agar and the like. The water-soluble polymer may form a salt, and the case where a salt is used is also included in the scope of the present invention.
Among these, xanthan gum, carboxymethyl cellulose, and carrageenan are particularly preferable water-soluble polymers to be combined with pullulan. These may be used alone or in combination of two or more.

  When pullulan and other water-soluble polymer are combined, the weight ratio thereof is preferably 1: 1 to 30: 1, more preferably 1: 1 to 10: 1, more preferably 1: 1 to 4: 1.

The water-soluble polymer sheet 2 preferably contains a humectant selected from polyhydric alcohols. In this case, the content of the humectant in the water-soluble polymer sheet is preferably 0 to 80% by weight. As the polyhydric alcohol, glycerin, propylene glycol, butylene glycol, propanediol, dipropylene glycol and the like can be used. Further, glycerin or diglycerin polyethylene glycol and / or polypropylene glycol adduct, polyethylene glycol, or the like can also be used. These may be used alone or in combination of two or more.
The molecular weight of polyethylene glycol is preferably 100 to 1000, more preferably 200 to 600. For example, polyethylene glycol 300 and 400 can be preferably used.
A humectant selected from polyhydric alcohols imparts flexibility to the water-soluble polymer sheet and contributes to improved handling.
The weight ratio of the water-soluble polymer to the humectant in the water-soluble polymer sheet 2 is preferably 1: 0 to 1: 4.

The water-soluble polymer sheet 2 may contain oil. The oil is not particularly limited as long as it is used for cosmetics. The oil content in the water-soluble polymer sheet in this case is preferably 0 to 35% by weight, more preferably 2 to 35% by weight. The oil is not particularly limited as long as it is used for cosmetics.
For example, higher fatty acids, higher alcohols, synthetic ester oils, liquid fats and oils, solid fats and oils, waxes, hydrocarbon oils and the like can be used.
In a preferred embodiment of the present invention, the oil contained in the water-soluble polymer sheet is a higher fatty acid, a higher alcohol, a solid fat or a wax.
The higher fatty acids are lauric acid, myristic acid, palmitic sun, stearic acid, and behenic acid.
The higher alcohols are lauryl alcohol, myristyl alcohol, palmityl alcohol, cetostearyl alcohol, stearyl alcohol, and behenyl alcohol.
Synthetic ester oils are isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyl decyl dimethyloctanoate, cetyl lactate, myristyl lactate, Lanolin acetate, isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearylate, ethylene glycol di-2-ethylhexylate, dipentaerythritol fatty acid ester, monoisostearic acid N-alkylglycol, dicaprate neopentyl glycol, malic acid diacid Isostearyl, glycerin di-2-heptylundecanoate, trimethylolpropane tri-2-ethylhexylate, trimethylolpropane triisostearate Bread, pentane erythritol tetra-2-ethylhexylate, glyceryl tri-2-ethylhexylate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, glyceryl trimyristate, tri-2-heptyl Undecanoic acid glyceride, castor oil fatty acid methyl ester, oleic acid oil, cetostearyl alcohol, acetoglyceride, 2-heptylundecyl palmitate, diisobutyl adipate, N-lauroyl-L-glutamic acid-2-octyldodecyl ester, adipic acid diester -2-heptylundecyl, ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate, succinate 2-ethylhexyl, ethyl acetate, butyl acetate, amyl acetate, and triethyl citrate.

  Liquid oils are avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, rice oil, rice germ oil, southern oil, castor Oil, flaxseed oil, safflower oil, cottonseed oil, eno oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, cinnagari oil, Japanese kiri oil, jojoba oil, germ oil, triglycerin, glycerin trioctanoate, Examples include glycerin triisopalmitate.

  Solid fats and oils are cocoa butter, coconut oil, horse fat, hardened coconut oil, palm oil, beef tallow, sheep fat, hardened beef tallow, palm kernel oil, pork fat, beef bone fat, owl kernel oil, hardened oil, cow leg fat, Owl, hardened castor oil, hardened palm oil, hardened macadamia nut oil, hardened jojoba oil and the like can be mentioned.

  The waxes include beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, ibota wax, whale wax, montan wax, nuka wax, lanolin, kapok wax, lanolin acetate, liquid lanolin, sugar cane wax, lanolin fatty acid isopropyl, lauryl hexyl, reduced lanolin, jojojo Examples thereof include a wax, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, POE hydrogenated lanolin alcohol ether, and the like.

  Examples of the hydrocarbon oil include liquid paraffin, ozokerite, squalene, pristane, paraffin, ceresin, squalene, petrolatum, and microcrystalline wax.

The weight ratio of the humectant to the oil in the water-soluble polymer sheet 2 is preferably 40: 1 to 0: 1, more preferably 3: 1 to 1: 3, and more preferably 2: 1 to 1: 2. .
The weight ratio of the water-soluble polymer to the oil component in the water-soluble polymer sheet 2 is preferably 40: 1 to 1: 3, more preferably 10: 1 to 2: 3, and more preferably 3: 2 to 1: 1. It is.

The water content in the water-soluble polymer sheet 2 is 10% by weight or less, more preferably 7% by weight or less, and still more preferably 5% by weight or less. The lower limit of the content is preferably 0.01% by weight, more preferably 0.1% by weight.
By setting the water content in such a range, it becomes easy to achieve both handleability and solubility.

  The water-soluble polymer sheet 2 may contain various other components for improving the skin condition, for example.

The thickness of the water-soluble polymer sheet 2 is preferably about 0.005 to 0.2 mm, more preferably about 0.01 to 0.1 mm, and more preferably about 0.02 to 0.1 mm.
The shape of the water-soluble polymer sheet can be arbitrarily determined, such as a circular shape, a square shape, or a heart shape. Although the area per one water-soluble polymer sheet can be set arbitrarily, when a thick sheet described above, preferably 0.5cm ² ~10cm ^2, more preferably 0.5～8Cm ² More preferably, it is 0.5-6 cm < ² >. By setting the area to this extent, it becomes possible to significantly improve the handleability.
The weight of the water-soluble polymer sheet 2 is preferably 0.001 to 1 g, more preferably 0.001 to 0.5 g, and more preferably 0.001 to 0.4 g.

The sealing material 3 covers one surface of the water-soluble polymer sheet 2. The sealing material 3 is formed of resin, paper, cloth, nonwoven fabric or the like. The sealing material 3 is attached to the water-soluble polymer sheet 2 by having a weak adhesive layer (not shown) on the contact surface with the water-soluble polymer sheet 2.
By covering the water-soluble polymer sheet 2 with the sealing material 3, the water-soluble polymer sheet 2 is easily handled when used.
Further, the sealing material 3 is preferably provided with a slit 4 for dividing the sealing material 3. The term “division” here includes not only the case where the sealing material is completely divided into two or more, but also the case where a part is divided. By providing the slit 4, the sealing material 3 can be easily peeled off from the water-soluble polymer sheet 2 when the skin external adhesive 1 is used.

  The external skin patch of this embodiment is used by peeling off the water-soluble polymer sheet 2 from the sealing material 3 and sticking the water-soluble polymer sheet 2 to the skin at the time of use. During this series of operations, the water-soluble polymer sheet 2 is not curled or twisted.

  Moreover, it is preferable that the surface of the water-soluble polymer sheet 2 is not wet. According to the present invention, even in such a form, it is possible to realize good handleability without causing the water-soluble polymer sheet 2 to be rounded or twisted.

  The external skin patch of the present invention can be provided as cosmetics, medicines and the like. In particular, it is preferably used as a cosmetic that dissolves by adding water (including lotion) on the skin. Thereby, the cosmetics which have the function as a moisturizing pack and the function as a lotion (lotion) can be provided.

  The skin external patch 1 of the present invention described above can be stored in a plastic container for storage and distribution. As the container, a tray type or a bag type is preferably used.

The skin external patch 1 of the present invention described above can be produced, for example, by the following method. An outline of the manufacturing method is shown in FIGS.
First, the components of the water-soluble polymer sheet are dispersed in water and coated on a resin film such as an OPP film. What dispersed the component of this water-soluble polymer sheet in water is substantially equivalent to what has the composition of the external composition for skin which is going to be finally applied to skin. In the present invention, a composition obtained by dispersing the components of the water-soluble polymer sheet in water is referred to as an external composition for skin.

The content of the water-soluble polymer in the external composition for skin is preferably 0.1 to 10% by weight.
In addition, pullulan is an essential component in the water-soluble polymer, and the proportion of pullulan in the external composition for skin is 0.1 to 10% by weight, preferably 0.2 to 7% by weight, more preferably 0.8. 3 to 6% by weight.
The amount of the other water-soluble polymer is preferably 0.1 to 4% by weight, more preferably 0.1 to 3.5% by weight, and more preferably 0.1 to 3% by weight.
The weight ratio of pullulan to other polymer is preferably 1: 1 to 30: 1, more preferably 1: 1 to 10: 1, and more preferably 1: 1 to 4: 1.
The content of the water-soluble polymer can be appropriately adjusted in consideration of the thickness of the sheet, ease of dissolution in water, and usability.

  The content of the humectant in the external composition for skin is preferably 0 to 10% by weight, more preferably 0.5 to 8% by weight. Further, by adopting the configuration of the present invention, even if the water-soluble polymer sheet contains a large amount of a humectant, there is no problem in the handleability of the sheet.

The oil content in the external composition for skin is preferably 0 to 5% by weight, more preferably 0.01 to 5% by weight, and more preferably 1 to 4% by weight. By adopting the configuration of the present invention, even if the water-soluble polymer sheet contains a large amount of oil, there is no problem in the handleability of the sheet.
That is, as a preferable form of the composition for external use of skin, 0.1 to 10% by weight of a water-soluble polymer, 0 to 10% by weight of a humectant, 0 to 5% by weight of oil, and 70 to 99% by weight of water. The form to include is mentioned.

The preparation method of the external composition for skin is not particularly limited. However, when the formulation contains an oil, it is preferably performed as follows.
First, among the components of the water-soluble polymer sheet 2, only the water-soluble polymer is dispersed in water (Liquid A). Subsequently, a humectant is added to and mixed with water (liquid A) in which the water-soluble polymer is dispersed (liquid B).
On the other hand, the oil is separately mixed and emulsified in water (liquid A) in which the water-soluble polymer is dispersed while heating (liquid C). The emulsion (Liquid C) thus obtained is mixed with water (Liquid B) in which the water-soluble polymer and the humectant obtained above are dispersed. Moreover, it is preferable to add additives, such as powder, a fragrance | flavor, and a preservative, after this.
The skin external composition thus prepared is applied onto the resin film 5 and dried until the water content is 10% by weight or less, preferably 7% by weight or less, more preferably 5% by weight or less. This dried product corresponds to the water-soluble polymer sheet 2 described above.

The water-soluble polymer sheet 2 obtained in this way is in a form laminated on the resin film 5 (FIGS. 3A and 4A).
Subsequently, as shown in FIGS. 3B and 4B, a seal in which a weak adhesive is applied to the surface of the water-soluble polymer sheet 2 opposite to the contact surface with the resin film 5. The material 3 is pasted. The sealing material 3 is preliminarily printed with cutting lines 61 and 62 having a predetermined shape (FIG. 3B).
In this embodiment, the circular cutting line 61 is printed on the sealing material 3, but the shape is not particularly limited.
Then, a slit is formed along the cutting line 62 printed on the sealing material 3 to form a slit 4 in the sealing material 3 (FIGS. 3C and 4C). The depth of the slit 4 is set to the depth of the sealing material 3 so as not to cut the water-soluble polymer sheet 2. Such a cutting method is called a half cut. In the present embodiment, the cutting line 62 printed on the sealing material 3 is corrugated, but the shape is not particularly limited.
Subsequently, the water-soluble polymer sheet 2 and the sealing material 3 are cut along the cutting line 61 printed on the sealing material 3 described above to form a notch 7 (FIGS. 3D and 4D). ).
Next, as shown in FIG. 3 (e) and FIG. 4 (e), the portion surrounded by the cut 7 of the water-soluble polymer sheet 2 is left, and the excess portion outside is removed.

EXAMPLES Hereinafter, the present invention will be described in more detail with reference to examples. However, the present invention is not limited to these examples. In the following examples,% is indicated by weight.
<Creation of water-soluble polymer sheet>
A water-soluble polymer sheet was prepared by the following production method so that the composition after drying of the water-soluble polymer sheet was as shown in Table 1.
Of the components shown in Table 1, a water-soluble polymer was added to water and mixed while heating to 80 ° C. to dissolve (disperse) (liquid A). Then, about the sample containing a moisturizer, the moisturizer was added to this, and it was set as 70 degreeC, and was set as the liquid B. On the other hand, oil was added to liquid A to obtain liquid C. Then, liquid B and liquid C were stirred and mixed with a homomixer to obtain a composition for external use on the skin. In addition, by adjusting the water content in the above step, the water content of the external composition for skin was finally set to 70 to 99% by weight.
The external composition for skin thus obtained was applied to a surface-treated polypropylene film (OPP film, Toyobo P2161OP # 60 polypropylene film, 4 cm × 6 cm) in an amount of 10 to 5000 g per 1 m ^{2 of} OPP film. Then, it was dried with a heat exchanger. Drying was performed until the water content of the water-soluble polymer sheet became 5% by weight or less. The thickness of the water-soluble polymer sheet was between 0.005 and 0.2 mm (see the lower part of Table 1).
After that, a sealing material coated with a weak adhesive is applied to the water-soluble polymer sheet, and a slit is formed in the sealing material as shown in FIG. The excess part outside the part was removed. Thus, the external skin patch of Examples 1-12 was created.

  Moreover, the external skin patch of Comparative Examples 1-12 was created by the manufacturing method similar to an Example so that the composition after drying of a water-soluble polymer sheet might come to show in Table 2. In Comparative Examples 2, 4, 5, 7, 10, and 11, since the sheet could not be formed, the external skin patch could not be prepared.

  About the external skin patches of Examples 1 to 12 and Comparative Examples 1 to 12 prepared above, (1) Ease of mixing the composition, (2) Can be applied to form a sheet, or (3) Sheet Evaluation was performed according to the following evaluation criteria from the viewpoint of adhesion between each other, degree of roundness, and (4) solubility in water. In addition, the skin external preparation of Examples 1-12 and Comparative Examples 1-12 evaluated 10 samples, respectively. The results of averaging the evaluation results (scores) are shown in Table 3 for the examples and Table 4 for the comparative examples.

(1) Ease of mixing of composition 4: Can be easily mixed 3: Can take a little time, but can be mixed 2: Can be quite uncooked 1: Cannot mix

(2) Can it be coated to form a sheet? 4: Can be easily formed into a sheet. 3: Slightly difficult to apply, but can be formed into a sheet. 2: Cannot be formed into a sheet. 1: Cannot be formed into a sheet at all.

(3) Adhesiveness between sheets, degree of rounding 4: Sheets do not adhere to each other and do not round 3: Sheets adhere slightly but easily peel off. Moreover, it is hard to curl 2: The sheets are slightly attached to each other. In addition, it is easy to curl and difficult to spread 1: Sheets are likely to adhere to each other. Also, it is easy to curl and cannot be expanded

(4) Solubility in water 4: Easily dissolves 3: It takes some time but dissolves 2: There is a part of undissolved 1: Almost insoluble

As a result of the evaluation, for the external skin patches of the examples, (1) ease of mixing of the composition, (2) coating to form a sheet, (3) adhesion between sheets, degree of roundness, (4) A high score was obtained in any evaluation of solubility in water.
On the other hand, for the external skin patch of the comparative example, (1) ease of mixing the composition, (2) whether it is applied to form a sheet, or (3) adhesion between sheets, degree of rounding, (4 ) In any of the evaluations of solubility in water, the evaluation results were low with respect to the examples. In Comparative Examples 2, 4, 5, 7, 10, and 11, since the sheet could not be formed, (3) the adhesion between sheets, the degree of roundness, and (4) the solubility in water could not be evaluated. .
The result is that the water-soluble polymer contained in the water-soluble polymer sheet is mainly composed of pullulan, the composition can be easily mixed, applied to form a sheet, or the adhesion between sheets, rounding. It is important for the degree and solubility in water.

1 skin patch 2 water-soluble polymer sheet 3 sealing material 4 slit 5 resin film

Claims (13)

An external skin patch comprising a water-soluble polymer sheet used without a support,
The water-soluble polymer sheet contains a water-soluble polymer mainly composed of pullulan,
Water content of the water-soluble polymeric sheet state, and are 10 wt% or less,
The water-soluble polymer includes one or more selected from the group consisting of xanthan gum, carboxymethylcellulose, and carrageenan,
A skin external patch , wherein the weight ratio of pullulan to one or more selected from the group consisting of xanthan gum, carboxymethylcellulose, and carrageenan is 1: 1 to 30: 1 . The skin according to claim 1, wherein the weight ratio of pullulan to one or more selected from the group consisting of xanthan gum, carboxymethylcellulose, and carrageenan is 1: 1 to 10: 1. External patch. The skin external patch according to claim 1 or 2 , wherein the content of pullulan is 50% by weight or more of the total amount of the water-soluble polymer. The external patch for skin according to any one of claims 1 to 3, wherein the water-soluble polymer sheet contains a humectant selected from polyhydric alcohols. The patch for external skin according to any one of claims 1 to 4 , wherein the water-soluble polymer sheet contains an oil. The patch for external application to the skin according to any one of claims 1 to 5 , which is used by being dissolved by adding water. The external patch for skin according to any one of claims 1 to 6 , wherein at least one surface of the water-soluble polymer sheet is coated with a peelable sealing material. The external skin patch according to claim 7 , wherein the sealing material is provided with a slit for dividing the sealing material. It is a manufacturing method of the external skin patch in any one of Claims 1-8 ,
A coating step of applying a composition for external use on the skin containing 0.1 to 10% by weight of a water-soluble polymer mainly composed of pullulan and 70 to 99.9% by weight of water;
The coated skin external composition is dried until the water content is 10% by weight or less, and a water-soluble polymer sheet is formed on the resin film, a sheet forming step,
I have a,
The external composition for skin contains one or more selected from the group consisting of xanthan gum, carboxymethyl cellulose, and carrageenan as the water-soluble polymer,
The weight ratio of pullulan and one or more selected from the group consisting of xanthan gum, carboxymethylcellulose, and carrageenan in the external composition for skin is 1: 1 to 30: 1 , A method for producing an external skin patch. In the external composition for skin, the weight ratio of pullulan and one or more selected from the group consisting of xanthan gum, carboxymethylcellulose, and carrageenan is 1: 1 to 10: 1, The manufacturing method of the external skin patch of Claim 9. The external composition for skin contains 0.1 to 8% by weight of pullulan and 0.01 to 4% by weight of one or more selected from the group consisting of xanthan gum, carboxymethylcellulose, and carrageenan. The method for producing an external skin patch according to claim 9 or 10 . The said external composition for skin contains 0-10 weight% of moisturizers chosen from a polyhydric alcohol, and 0.01-5 weight% of oil content , The any one of Claims 9-11 characterized by the above-mentioned. For producing a skin external patch. After the sheet forming step, a surface of the water-soluble polymer sheet opposite to the resin film contact surface is coated with a peelable sealing material, and a water-soluble polymer sheet coated with the sealing material is predetermined. Cutting into a shape of
The method for producing an external skin patch according to any one of claims 9 to 12 , characterized by comprising:

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