JP6236052B2 - Mouth cavity preventive powder and method for producing mouth cavity preventive powder - Google Patents

Description

  The present invention relates to a dental caries preventive powder.

  In Patent Document 1, a purine-like food containing only 1% by weight to 70% by weight of a sugar alcohol as a sweetener, and the sugar alcohol is any one of xylitol, erythritol, and maltitol. A purine-like food that is a seed or a mixture of two or more is disclosed.

JP 2008-148614 A

  In the mouth, no powder was sold to prevent tooth decay by having no abrasive and applying powder to teeth.

  The present invention is to provide a powder capable of preventing caries more effectively by a simple method.

  The oral cavity preventive powder of the present invention contains salivary streptococci in a living state, and does not contain at least a bactericidal component or a polishing component.

  Preferably, the living salivary streptococci are contained in lactic acid powder which is a granular powder.

  Preferably, apart from the lactic acid powder, it contains a granular bulking powder.

  Suitably, the bulking powder contains at least an oligosaccharide.

  Preferably, the ratio between the lactic acid powder and the bulking powder is in the range of 1/5 to 1/200.

  Suitably, the bulking powder comprises dextrin.

  Suitably, the bulking powder comprises erythritol.

Preferably, the bulking powder comprises oligosaccharides and dextrin and erythritol, the oligosaccharide is in the range of 10% to 40% with respect to the whole bulking powder, and the dextrin is 40% with respect to the whole bulking powder. % To 70%, and erythritol is in the range of 10% to 30% with respect to the whole of the expanded powder.
Method for producing a mouth anticaries powder, a granular powder Der Ru lactate powder free of biocidal component comprises live lactobacilli, and bulking powder is granular powder, and sealed in the same container A first step and a second step of vibrating the container up and down.
Preferably, the container formed to absorb impact is used.
Preferably, the temperature is controlled between 20 ° C and 30 ° C.

  According to the present invention, it is possible to provide a powder capable of preventing caries more effectively by a simple method.

It is explanatory drawing which shows the manufacturing method of the oral cavity prevention powder of this invention. It is explanatory drawing of the method of the secondary mixing of step S111.

Conventionally, for example, the following methods are recommended to prevent tooth decay.
(1) Encourage tooth brushing after each meal (2) Refrain from sweet foods (3) Use a sweet-feeling substance that cannot be decomposed by the bacteria that produce caries for food, etc. There is only an effect that prevents the growth of itself (hereinafter simply referred to as “caries fungus”).

In this embodiment, the first object is to prevent the growth of caries fungi, and the object is to reduce the number of caries fungi at an extremely low level.
As a specific means, lactic acid bacteria are spread alive in the mouth to suppress the growth of caries.
As a result of diffusing lactic acid bacteria alive in the mouth, the number of dental bacteria is suppressed to a very low level as a result of the following.
(1) Lactic acid bacteria attack lactic acid bacteria (2) Lactic acid bacteria occupy the living environment of caries fungi (3) Lactic acid bacteria consume caries fungi first

Here, the lactic acid bacterium is more preferably an oral streptococcus.
Furthermore, the oral streptococcal lactic acid bacterium is oral streptococcus M18.
At present, Streptococcus cerevisiae has determined that BLIS M18 from New Zealand Bliss Technology is optimal, but this is not meant to be limiting.
Similarly, as optimal, at present, oral streptococci have determined that BLIS K12 from New Zealand Bliss Technology is the optimal.

Oral streptococci were usually bacteria in the mouth and were thought to be caries. However, it was discovered that some of the oral streptococci do not become caries.
When various bacteria were tested among the on-site streptococci, it was found that the oral streptococcus M18 is the most powerful fungus having such a function so far.
In addition, Bliss Technology's BLIS M18 was found to be optimal.
(Blis Technology's BLIS K12 was also optimal, but for the sake of explanation, only BLIS M18 will be described below.)
BLIS M18 (and BLIS K12) is a living lactic acid bacterium (oral streptococcus M18).
Hereinafter, BLIS M18 manufactured by BLIS will be described as an example of lactic acid bacteria, an example of oral streptococci, and an example of oral streptococci, but the present invention is not limited thereto. It is simply described to the effect of describing the presently preferred embodiment.

Lactic acid bacteria themselves are very small.
In addition, the amount of diffusion (application, application) to the teeth in the mouth is very small.
Therefore, the required amount of BLIS M18 is very small.
Probably, by adding components other than bacteria as well as BLIS M18, it seems that the amount is inflated so as to increase the mass per certain amount of bacteria, but the amount is still very small. BLIS M18 has a granular shape.
Such a situation seems to be the same even when bacteria other than BLIS M18 are used.
Specifically, the required amount of BLIS M18 required to prevent tooth decay is only 20 mg. 20mg is just one cup of earpick. It is determined that 20 mg is an appropriate amount at present.
This is too little, and even if it is put directly into the mouth, it is difficult to spread the entire toothed part of the mouth.
In addition, in order to spread the entire tooth part in the mouth more surely, it is considered to sprinkle the BLIS M18 on an object acting as a toothbrush or a toothbrush and brush it against the tooth. It is done.
However, even in this case, the amount is very small at 20 mg, and the user may be wondering about the fact of use and the effect.
Moreover, at 20 mg, it is equivalent to one earpick, so it is possible to blow and blow away.
Furthermore, 20 mg is too small and difficult to package in small portions, and a predetermined amount is contained in a large container, and then it is measured with a spoon like an earpick.
Therefore, using BLIS M18 as it is is inconvenient for consumers from various points of view.

Therefore, the inventor has found that when used as a dental caries-preventing powder, it is granular, and it is necessary to increase the amount by mixing lactic acid powder containing BLIS M18 and bulking powder. .
In addition, lactic acid powder means what contains lactic acid bacteria (the specific example here is BLIS M18).
And it discovered that the convenience of use was high when combining lactic acid powder and bulking powder to about 1000 mg.
That is, the ratio of the lactic acid powder to the expanded powder is 20 to 980 (1:49, 1/49).
However, this ratio can be appropriately changed depending on the amount of lactic acid bacteria contained in the lactic acid powder.
In addition, the reason why the lactic acid powder and the bulking powder are combined to make about 1000 mg is that this amount is an appropriate amount when sprinkled on a toothbrush and applied with a toothbrush as it is.
Thus, what mix | blended lactic acid powder and the bulking powder becomes the oral cavity prevention powder in an Example.

However, 1000 mg can be changed as appropriate.
As a result of experimenting by changing the ratio, it was found that if the ratio is 1/5 to 1/200, there is a certain degree of appropriateness.
Furthermore, 1/20 to 1/70 was found to be more appropriate.
The current optimum is 1/49 as described above.

The oral cavity preventive powder does not need to contain a bactericidal component or a polishing component contained in a normal toothpaste.
Rather, the sterilizing component is harmful because it sterilizes lactic acid bacteria.
In addition, a polishing component is unnecessary because the oral cavity preventive powder of the present invention is not for removing dirt from teeth. Rather, it is unnecessary because there is a risk of sterilizing lactic acid bacteria by polishing with teeth. However, since the abrasive component is not as harmful as a bactericidal agent, it is possible to include oral cavity preventive powder.
In addition, the lactic acid bacteria represented by BLIS M18 contained in lactic acid powder are contained in lactic acid powder in a living state.
Here, the oral preventive powder of the present invention need not contain any one of the sterilizing component or the polishing component, but more preferably it does not contain both the sterilizing component or the polishing component. Needless to say.
Moreover, since the oral cavity caries preventive powder of the present invention itself has an effect of preventing caries, it does not need to contain a fluorine compound.
Therefore, the oral cavity prevention powder of the present invention may contain fluorine, but it is more preferable not to contain a fluorine compound.

The bulking powder is granular like the lactic acid powder.
Suitably, the bulking powder contains at least an oligosaccharide.
This is because lactic acid bacteria represented by BLIS M18, when oligosaccharide is present, grows using it as nutrition.
Then, when lactic acid bacteria represented by BLIS M18 grow in the mouth, other bacteria that generate caries attack, etc., and the bacteria that generate caries decrease, and the generation of caries is greatly suppressed.
Here, as the oligosaccharide, for example, as the oligosaccharide, isomaltoligosaccharide, lactulose, palatinose, fructooligosaccharide, raffinose, stachyose, xylo-oligosaccharide, malto-oligosaccharide, trehalose, galactooligosaccharide, whey oligosaccharide, beet oligosaccharide, Examples include gentiooligosaccharide, nigerooligosaccharide, sucrose, lactose, maltose, cyclodextrin and the like.
Furthermore, since it has an oligosaccharide in this way, it becomes possible to make the user feel sweet when using this oral cavity preventive powder.
Thereby, the effect that the user can use the oral cavity preventive powder without resistance can be expected.

More suitably, the bulking powder further comprises dextrin and erythritol.
Dextrin or erythritol can be substituted with the following sugars and the like. Examples include isomerized liquid sugar, sorbitol, starch syrup, oligosaccharide, trehalose, lactose, xylitol, starch saccharified product, reduced starch saccharified product, reduced starch syrup, reduced lactose, honey, brown sugar, glycerin, etc. Can be used.
However, at present, we have determined that dextrin and erythritol are optimal.
The reason is that dextrin was required for granulation and adjustment of clay soil.
On the other hand, dextrin is tasteless and odorless and is also used as a food, so it was judged that the dextrin is highly safe even in the mouth.
Furthermore, erythritol is a sweetener that gives a refreshing sensation and does not produce tooth decay.
Both dextrin and erythritol are not essential, and only one of them exhibits a predetermined function.
Furthermore, dextrin and erythritol can also make the user feel sweet when using this oral cavity preventive powder.
Thereby, the effect that the user can use the oral cavity preventive powder without resistance can be expected.

As mentioned above, the bulking powder contains oligosaccharides and dextrin and erythritol.
And the oligosaccharide is in the range of 10% to 40% with respect to the whole extended powder, the dextrin is in the range of 40% to 70% with respect to the whole extended powder, and the erythritol is in the whole powder. As a result of experiments, it was found that the range of 10% to 30% is appropriate.
When there is too much erythritol and oligosaccharide, it will become too sweet, and it was appropriate to make the quantity which combined both into the above quantity.
However, if there are too few erythritol and oligosaccharides, sweetness cannot be felt and resistance will become large when a child etc. use.
As a result of these two adjustments, the amounts of erythritol and oligosaccharide are determined.
In addition, a certain amount of oligosaccharide is necessary for the lactic acid bacteria of BLIS M18 to nourish and grow it.
However, if it is too much, it becomes too sweet and there is a possibility that lactic acid bacteria may be activated too much after the production of oral cavity caries preventive powder.
In addition, erythritol requires a certain amount of charge in order to give a refreshing feeling, but if it is added too much, the refreshing feeling is too effective to be accepted by the user, so it is determined at the above ratio.
Next, dextrin is added to the oral cavity preventive powder to prevent the powder from being broken (= stabilized). Furthermore, dextrin is added to the oral cavity preventive powder for granulation. Therefore, dextrin requires a certain amount of material to stabilize and granulate without breaking. In particular, in the case of manufacturing by shaking as described later, a certain amount is required to prevent crushing.
On the other hand, dextrin itself has no particular effect, so it is necessary to refrain as much as possible.
Therefore, the said ratio was suitable for the ratio of dextrin.
As a result of examining all of the above elements, oligosaccharides are in the range of 10% to 40% with respect to the whole expanded powder, dextrins are in the range of 40% to 70% with respect to the entire expanded powder, and erythritol Was in the range of 10% to 30% with respect to the whole of the expanded powder.
In addition, it is more appropriate to produce an expanded powder with 61.6% dextrin, 19.2% oligosaccharide and 19.2% erythritol.

The bulking powder and lactic acid powder are each in the form of granules.
Since both the expanded powder and the lactic acid powder are in the granular form, it is possible to mix the expanded powder and the lactic acid powder relatively easily.
In addition, since both the bulking powder and the lactic acid powder are granular, they can be mixed uniformly.
Furthermore, since both the expanded powder and the lactic acid powder are granular, it is possible to mix the expanded powder and the lactic acid powder without generating heat or pressure.
This is because lactic acid bacteria may be killed when heat or pressure is generated.
In addition, since both the expanded powder and the lactic acid powder are granular, they can be mixed without using water or the like. This is because, when water is present, lactic acid bacteria activate their activities at the manufacturing stage, causing problems in quality.

It should be noted that ordinary paste-like toothpaste and the like cannot provide lactic acid bacteria as they are alive because water or the like is required to obtain a paste.
On the other hand, the oral cavity preventive powder according to the present example has both granular powder and lactic acid powder in a granular form, so that it is possible to produce a powder that supplies lactic acid bacteria into the mouth alive.

  FIG. 1 is an explanatory view for explaining an example of a method for producing an oral cavity caries prevention powder.

Fragrance A is various fragrances. Specifically, strawberry flavor and yogurt flavor.
In step S101, the strawberry flavor and the yogurt flavor are mixed.
The resulting mixture is a mixed fragrance B.
In addition, the strawberry flavor and the yogurt flavor are used in order to eliminate discomfort in use because the oral cavity preventive powder is considered to be used for children.
However, since it is a fragrance | flavor to the last, it can change variously.
Further, in some cases, it is possible not to use a fragrance.

A weight-increasing material C containing 61.6% dextrin, 19.2% oligosaccharide, and 19.2% erythritol is prepared.
In step S103, the bulk material C and the mixed fragrance B are mixed to produce a primary mixture (primary mixing).
Next, in step S105, the primary mixture is granulated so as to be granulated to generate a granulated product.
Furthermore, in step S107, the granulated product is dried. Here, since it does not contain lactic acid bacteria, it is possible to take various drying methods such as raising the temperature, conversely drying at a low temperature, or sending air of low humidity.
For the festival, the sizing is performed in step S109. Specifically, it is more appropriate that the size of the granule is 20 mesh or more and 80 mesh or less.
The primary granule B can be manufactured through these steps.
This primary granule B is an expanded powder.

Granular lactic acid powder E containing BLIS M18 (Lactic acid bacteria, Streptococcus saliva in the mouth) and an expanded powder (primary granules D) are mixed to produce a secondary mixture F (secondary mixing). Specifically, this will be described with reference to FIG.
This secondary mixture F is an oral cavity preventive powder.

In step 113, the number of bacteria in the oral cavity preventive powder is measured.
This is to check whether BLIS M18 (lactic acid bacteria, streptococcus saliva in the mouth) has been killed to a predetermined amount or more.

In step 115, each 1000 mg is divided into bags that are impermeable to light, moisture and the like.
Finally, in step S117, the box is packed. The boxed product will be shipped.

In the manufacturing process of FIG. 1, the temperature in the manufacturing chamber is appropriately controlled within the range of 15 ° C. to 40 ° C.
More suitably, the temperature in the manufacturing chamber is 20 ° C to 25 ° C.
This temperature range is the most effective for preventing dental caries prevention powders without destroying the granules of BLIS M18 (lactic acid bacteria, oral salivary streptococci) and killing as much as possible of living lactic acid bacteria (oral salivary streptococci). Because it becomes possible to do.
As for this temperature, the lower temperature can prevent the activity of lactic acid bacteria. On the other hand, if the temperature is too low, the working efficiency of the worker during production decreases.
Moreover, if it is too low, the electricity bill will increase for temperature control.
On the other hand, if the temperature is too high, the work efficiency of the worker is reduced and the electricity bill in winter is increased. Moreover, it is because lactic acid bacteria will be activated too much, and if it is more than that, lactic acid bacteria will be killed.

  FIG. 2 is an explanatory diagram of the secondary mixing method in step S111.

As shown in FIG. 2, a predetermined amount of the powder L and the granular lactic acid E containing BLIS M18 (lactic acid bacteria, oral salivary streptococci) are added to the container 1 on the same day.
Specifically, the ratio between the lactic acid powder D and the bulking powder E is 2 to 98 (1:49, 1/49). For example, the total amount of the lactic acid powder D and the expanded powder E is charged to 10 kg.
Then, the lid is closed and sealed (first step)
And the container 1 is vibrated (2nd process). In particular, mixing is possible by shaking up and down.
Shaking shakes that move up and down too much may break the granules of the lactic acid powder D and the bulking powder E, so it is not appropriate to shake them greatly.
Therefore, the distance of 200 to 400 mm is shaken at a rate of 40 to 100 times per minute.
The container 1 is particularly preferably a bag (plastic bag) or the like.
This is because a metal container is likely to collide with a wall and destroy granules of lactic acid powder D and bulking powder E. On the other hand, in the case of a plastic bag, it is possible to reduce the impact.
That is, it is appropriate that the container 1 is formed so as to absorb an impact.
Since secondary mixing is performed by such a method, it is possible to mix without destroying the granules and killing living lactic acid bacteria (oral salivary streptococci) as much as possible.
This mixing method is merely an example, and other methods may be used as long as they are uniformly mixed, the granules are not broken, and the living lactic acid bacteria are not killed.

<Configuration and Effect of Example>
The oral cavity preventive powder contains salivary streptococci in a living state, and does not contain at least a bactericidal component or a polishing component.
Since it has such a structure, it becomes possible to provide the powder which can prevent a tooth decay more effectively by a simple method.

Living saliva streptococci are contained in lactic acid powder, which is a granular powder.
Since it has such a configuration, mixing and the like can be easily performed.

Apart from lactic acid powder, it contains granulated bulking powder.
Since it has such a structure, it becomes possible to provide a user with an appropriate amount.

The bulking powder contains at least an oligosaccharide.
Since it has such a structure, it becomes possible to activate salivary streptococcus more.
Furthermore, since it has such a configuration, there is an effect that the user can use the oral cavity preventive powder without resistance.

The ratio between the lactic acid powder and the bulking powder is in the range of 1/5 to 1/200.
Since it has such a structure, it becomes possible to provide a user with an appropriate amount.

The bulking powder contains dextrin.
Since it has such a structure, it becomes possible to activate salivary streptococcus more.
Furthermore, since it has such a configuration, there is an effect that the user can use the oral cavity preventive powder without resistance.

The bulking powder contains erythritol.
Since it has such a structure, it becomes possible to activate salivary streptococcus more.
Furthermore, since it has such a configuration, there is an effect that the user can use the oral cavity preventive powder without resistance.

The bulking powder contains oligosaccharides and dextrin and erythritol, the oligosaccharides are in the range of 10% to 40% with respect to the whole bulking powder, and the dextrin is in the range of 40% to 70% with respect to the whole bulking powder. Yes, erythritol is in the range of 10% to 30% with respect to the whole of the expanded powder.
Since it has such a structure, it becomes possible to activate salivary streptococci more appropriately.
Furthermore, since it has such a configuration, it has the effect that the user can use the oral cavity preventive powder most appropriately without resistance.

The method for producing oral cavity preventive powder is a method of enclosing lactic acid powder, which is a granular powder containing live lactic acid bacteria and no bactericidal component, and a bulking powder, which is a granular powder, in the same container. 1 process and the 2nd process which vibrates a container up and down.
Since it has such a structure, it can mix uniformly, without destroying a granule and without killing living lactic acid bacteria.

As the container, a container formed so as to absorb an impact is used.
Since it has such a structure, it becomes possible to mix without destroying a granule more.

The production is temperature controlled between 20 ° C and 30 ° C.
Since it has such a configuration, it can be mixed without killing more live lactic acid bacteria.

  The above examples are merely examples, and other ratios, components, manufacturing methods, and the like can be taken.

A Strawberry flavor and yogurt flavor (fragrance)
B Strawberry yogurt flavor (mixed flavor)
C dextrin, oligosaccharide, erythritol (increasing material)
D Temporary granule (bulk powder)
E BLIS M18 (lactic acid bacteria, oral salivary streptococci, BLIS K12)
F Oral cavity preventive powder

Claims (9)

Living include saliva streptococci in state, a bactericidal component or polishing, mouth and anticaries powder not including components even without low,
In the living state, salivary streptococci are contained in lactic acid powder, which is a granular powder .
In addition to the lactic acid powder, an oral cavity preventive powder containing a granular powder. The bulking powder contains at least an oligosaccharide
The oral cavity preventive powder according to claim 1 . The ratio of the lactic acid powder to the above-mentioned bulking powder is in the range of 1/5 to 1/200 in weight ratio.
The oral cavity preventive powder according to claim 1 or 2 . The bulking powder contains dextrin
The oral cavity preventive powder according to any one of claims 1 to 3 . The bulking powder contains erythritol
The oral cavity preventive powder according to claim 4 . The bulking powder includes oligosaccharides and dextrin and erythritol,
Oligosaccharides range from 10% to 40% in weight percent with respect to the whole bulking powder,
Dextrin ranges from 40% to 70% in weight percent with respect to the whole bulking powder;
Erythritol ranges from 10% to 30% in weight percent with respect to the whole bulking powder.
The oral cavity preventive powder according to any one of claims 1 to 5 . A first step of enclosing a lactic acid powder that is a granular powder that contains living lactic acid bacteria and does not contain a bactericidal component, and an expanding powder that is a granular powder, in the same container;
And a second step of vibrating the container up and down. Use the container configured to absorb shocks
The manufacturing method of the dental caries prevention powder of Claim 7 . Temperature controlled between 20 ° C and 30 ° C
The manufacturing method of the dental caries prevention powder of Claim 8 .

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