JP6249641B2 - Liquid oral composition - Google Patents

Description

  The present invention relates to a liquid oral composition.

  Phytic acid is known to have actions such as removing cigarette dust, suppressing tartar, stabilizing tin fluoride, and is used in various oral compositions. For example, Patent Document 1 reports a dentifrice containing phytic acid, and also a composition for oral cavity (Patent Document 2) containing zeolite in addition to phytic acid, or particles having a specific disintegration strength (patent A dentifrice composition containing Reference 3) has also been reported. Furthermore, the present applicant has not been able to sufficiently remove a small solid material having a height of less than 1 μm attached to the tooth surface with a conventional whitening agent or abrasive, but contains phytic acid and contains a polyvalent cation. Without using a composition in which the pH is adjusted to a certain range, or a composition using phytic acid and pyrophosphoric acid or a salt thereof in a specific quantitative ratio, fine solids adhering to the tooth surface can be removed. It has already been reported that teeth can be whitened and gloss can be imparted to the teeth (Patent Documents 4 to 5).

  On the other hand, phenoxyethanol has been reported to have a chemical action to remove stains such as stains, plaques, and cigarette stains on tooth surfaces. For example, in Patent Document 6, in order to improve the chemical cleaning performance with phenoxyethanol, in addition to the combined use of phenoxyethanol, a surfactant, and a propionic acid alkyl ester having a total carbon number of 5 or more, water-soluble polyphosphoric acid is used. The use of salt in combination has also been reported.

Japanese Patent Laid-Open No. 56-18913 JP-A-11-349460 JP 2003-335646 A International Publication No. 2010/058522 Pamphlet International Publication No. 2012/137951 Pamphlet JP 2002-471161 A

  Although the composition containing phytic acid described in Patent Documents 1 to 5 removes the sticking matter generated on the tooth surface and enamel trabecular space and brings a whitening effect to the teeth, such an effect is obtained. In order to further improve, it is required to further enhance the effect of removing dirt on the teeth that adheres on a daily basis. Further, as described in Patent Document 6, phenoxyethanol is known to have stain removal performance such as stains on the tooth surfaces, plaques, tobacco spears, etc., but the stain removal performance by phenoxyethanol alone is low. Furthermore, a liquid oral composition capable of effectively removing dirt on the tooth surface is desired.

  Therefore, the present invention relates to a composition for a liquid oral cavity that can sufficiently exhibit the effect of removing colored stains on the tooth surface, enhance the whitening effect of the tooth, and provide a feeling that the tooth surface is smooth.

  Therefore, the present inventor previously discovered that the components in the fine solid product having a thickness of less than a few μm attached to the tooth surface include not only calcium phosphates but also organic matter, To prevent the fine solid product on the tooth surface from adhering again due to the mixing of calcium phosphates with calcium phosphates, in order to exert this effect more fully, excessive coloring stains that are adhered by daily eating and drinking, etc. It was found that a removal effect is also required. However, in an environment where the pH is controlled, in addition to a specific amount of phytic acid and pyrophosphoric acid, in combination with a specific amount of phenoxyethanol, it is possible to drastically suppress coloring stains adhering unexpectedly due to eating and drinking. The headline and the present invention have been completed.

That is, the present invention includes the following components (A) to (C):
(A) Phytic acid or its salt 0.01 mass% or more and 3 mass% or less in acid conversion amount (B) Pyrophosphoric acid or its salt 0.01 mass% or more and 3 mass% or less in sodium salt conversion amount, and (C) Phenoxyethanol 0.1% by mass or more and 1% by mass or less, no polyvalent metal cation, or less than 0.1 times mol of component (A), and a liquid having a pH of 5.5 to 7 The present invention relates to an oral composition.

According to the liquid oral cavity composition of the present invention, the effect of removing colored stains on the tooth surface by eating and drinking, etc. can be sufficiently exerted, the whitening effect of the tooth can be enhanced, and the tooth surface feels smooth. Can be obtained.
Note that the feeling that the surface of the teeth is smooth refers to a feeling that when the surface of the tooth is touched with the tongue, the tongue can be smoothly slid without feeling any friction.

Hereinafter, the present invention will be described in detail.
The composition for liquid oral cavity of the present invention contains phytic acid or a salt thereof as an ingredient (A) in an amount of 0.01% by mass to 3% by mass in terms of acid. Phytic acid or a salt thereof has an excellent whitening effect on teeth, and by applying to a tooth together with pyrophosphoric acid or a salt thereof (B) and phenoxyethanol (C) described later, colored stains attached by eating and drinking etc. The effect of removing can be enhanced, and the whitening action can be enhanced.
Also known as myo-inositol 6-phosphate, it is an inositol phosphate compound. Among various phosphoric acid compounds, phytic acid or a salt thereof is particularly excellent in the gloss imparting effect.
Examples of the salt include alkali metal salts such as sodium and potassium, ammonium salts, and the like. From the viewpoint of taste and odor, alkali metal salts are preferable, and sodium is more preferable.

  The content of the component (A) is sufficient in terms of acid conversion in the liquid oral composition of the present invention from the viewpoint of sufficiently maintaining the effect of removing minute solid products and effectively exhibiting the effect of suppressing tooth coloring. 0.01% by mass or more, preferably 0.05% by mass or more, more preferably 0.1% by mass or more, and still more preferably from the viewpoint of improving the feeling that the tooth surface is slippery. It is 0.2% by mass or more. The content of the component (A) is the liquid oral cavity of the present invention from the viewpoint of further improving the performance of removing colored stains attached by eating and drinking together with the component (B) pyrophosphoric acid or a salt thereof and the component (C) phenoxyethanol described later. In the composition for an acid, it is 3% by mass or less in terms of acid, and from the viewpoint of flavor and squeak, it is preferably 1.5% by mass or less, more preferably 1% by mass or less, in terms of acid. More preferably, it is 0.7 mass% or less. Moreover, content of a component (A) is 0.01-3 mass% in an acid conversion amount in the liquid oral cavity composition of this invention, Preferably it is 0.05-1.5 mass%. More preferably, it is 0.1-1 mass%, More preferably, it is 0.1-0.7 mass%, More preferably, it is 0.2-0.7 mass%. In addition, the content of phytic acid or a salt thereof in the liquid oral composition of the present invention is measured by neutralizing with potassium hydroxide or sodium hydroxide, and an acid equivalent amount obtained by converting the total amount into an acid is adopted.

  The composition for liquid oral cavity of the present invention contains 0.01 mass% or more and 3 mass% or less of pyrophosphoric acid or a salt thereof as a component (B) in terms of sodium salt. The content of pyrophosphoric acid or a salt thereof is an amount converted to sodium salt, specifically, an amount converted to tetrasodium pyrophosphate. By containing the component (B) so as to have such a content, the effect of removing fine solid products is further enhanced, and it is adhered by eating and drinking, etc., in combination with the component (A) and the component (C) described later. The removal performance of the colored stain on the teeth can be improved. Examples of the salt of component (B) include alkali metal salts and ammonium salts selected from sodium and potassium, alkali metal salts are preferable from the viewpoint of flavor and odor, sodium salts and potassium salts are more preferable, sodium salts Is more preferable.

  The content of the component (B) is 0.01% by mass or more in terms of sodium salt in the liquid oral cavity composition of the present invention from the viewpoint of enhancing the performance of removing colored stains attached to teeth by eating and drinking. Thus, it is preferably 0.05% by mass or more, and more preferably 0.1% by mass or more. The content of the component (B) is 3% by mass or less in terms of sodium salt in the liquid oral composition of the present invention from the viewpoint of effectively ensuring a good feel and flavor when applied to the oral cavity. Thus, it is preferably 1.5% by mass or less, more preferably 1% by mass or less, and further preferably 0.7% by mass or less. Moreover, content of a component (B) is 0.01 mass% or more and 3 mass% or less in conversion amount of sodium salt in the liquid oral cavity composition of this invention, Preferably it is 0.05-1.5 mass. %, More preferably 0.1 to 1% by mass, and still more preferably 0.1 to 0.7% by mass.

  The mass ratio (B / A) of the sodium salt equivalent of component (B) and the acid equivalent of component (A) is preferably from the viewpoint of effectively enhancing the ability to remove colored stains on teeth attached by eating or drinking. It is 0.1 or more, More preferably, it is 0.2 or more, More preferably, it is 0.4 or more. The mass ratio (B / A) of the sodium salt equivalent of component (B) and the acid equivalent of component (A) ensures the removal performance of fine solid products containing calcium phosphate and the like deposited on the tooth surface. From the viewpoint of enhancing the performance of removing colored stains attached by eating and drinking, and effectively ensuring a good feel and flavor, it is preferably 7 or less, more preferably 5 or less, and even more preferably 4 or less. From the viewpoint of improving the feeling that the tooth surface is smooth, it is more preferably 3 or less. Moreover, the mass ratio (B / A) of the sodium salt conversion amount of the component (B) and the acid conversion amount of the component (A) is preferably 0.1 or more and 7 or less, more preferably 0.2-5. More preferably, it is 0.4-4, More preferably, it is 0.4-3.

  The total of the acid equivalent amount of component (A) and the sodium salt equivalent amount of component (B) adheres to the teeth by eating and drinking while ensuring the removal performance of fine solid products including calcium phosphate deposited on the tooth surface. From the viewpoint of effectively enhancing the colored stain removal performance, the liquid oral composition of the present invention is preferably 0.02% by mass or more, more preferably 0.1% by mass or more, and still more preferably. It is 0.2 mass% or more, More preferably, it is 0.5 mass% or more. The sum of the acid equivalent amount of component (A) and the sodium salt equivalent amount of component (B) is the removal performance of fine solid products deposited on the tooth surface and the removal performance of colored stains attached to the teeth by eating and drinking. From the viewpoint of effectively ensuring a good feel and flavor that suppresses squeakiness and saltiness at the time of application to the oral cavity while enhancing, preferably 5% by mass or less, more preferably 3% by mass or less, More preferably, it is 1 mass% or less. Moreover, the sum total of the acid conversion amount of component (A) and the sodium salt conversion amount of component (B) is preferably 0.02 to 5 mass%, more preferably 0.1 to 3 mass%, Preferably it is 0.2-3 mass%, More preferably, it is 0.5-1 mass%.

  The composition for liquid oral cavity of the present invention contains 0.1% by mass or more and 1% by mass or less of phenoxyethanol as the component (C). By containing the component (C) so as to have such a content, the combined use of the component (A) and the component (C) described later can improve the removal performance of the colored stains on teeth attached by eating and drinking. it can. That is, phenoxyethanol alone does not exhibit the ability to remove colored stains on teeth, so even if component (A) and component (C) are used in combination, component (B) and component (C) are used in combination. Although the stain removal performance cannot be improved, by using the component (C) together with the component (A) and the component (B), the stain removal performance by the component (A) and the component (B) is dramatically improved. can do.

  The content of the component (C) is 0.1% by mass or more in the liquid oral cavity composition of the present invention, preferably 0, from the viewpoint of enhancing the performance of removing colored stains attached to teeth by eating and drinking. .2% by mass or more, and more preferably 0.3% by mass or more. The content of the component (C) is 1% by mass or less in the liquid oral composition of the present invention, preferably from the viewpoint of effectively ensuring a good feel and flavor when applied to the oral cavity, preferably It is 0.7 mass% or less, More preferably, it is 0.5 mass% or less. Moreover, content of a component (C) is 0.1 to 1 mass% in the liquid oral cavity composition of this invention, Preferably it is 0.2-0.7 mass%, More Preferably it is 0.3-0.5 mass%.

  The total ratio of the sodium salt equivalent amount of component (B) and the content of component (C) and the mass ratio ((B + C) / A) of the acid equivalent amount of component (A) is the coloring of teeth attached by eating and drinking. From the viewpoint of effectively enhancing the dirt removal performance, it is preferably 0.5 or more, more preferably 1 or more, and even more preferably 1.5 or more. The total ratio of the sodium salt equivalent amount of component (B) and the content of component (C) and the mass ratio ((B + C) / A) of the acid equivalent amount of component (A) is the coloring of teeth attached by eating and drinking. From the viewpoint of enhancing the dirt removal performance and effectively ensuring storage stability and good flavor, it is preferably 15 or less, more preferably 12 or less, even more preferably 10 or less, and the tooth surface is From the point which improves the slippery feeling, More preferably, it is 6 or less. Moreover, the mass ratio ((B + C) / A) of the total amount of component (B) in terms of sodium salt and component (C) and the amount in terms of acid of component (A) ((B + C) / A) is preferably 0.5 to It is 15, More preferably, it is 1-12, More preferably, it is 1.5-10, More preferably, it is 1.5-6.

  The mass ratio (C / (A + B)) of the content of the component (C) and the total amount of the acid equivalent of the component (A) and the sodium salt equivalent of the component (B) is the coloring of the teeth attached by eating and drinking. From the viewpoint of effectively enhancing the dirt removal performance and obtaining a smooth feeling of teeth, it is preferably at least 0.1, more preferably at least 0.4, and even more preferably at least 0.5. The mass ratio (C / (A + B)) of the sum of the component (A) acid equivalent amount and the component (B) sodium salt equivalent amount to the component (C) content is the coloration of the teeth attached by eating and drinking. From the viewpoint of effectively enhancing the dirt removal performance, and from the viewpoint of obtaining a smooth feel of the teeth and the balance with the flavor, it is preferably 2 or less, more preferably 1.5 or less, and even more preferably 1 Or less, more preferably 0.9 or less.

  The composition for liquid oral cavity of the present invention does not contain a polyvalent metal cation or contains less than 0.1 times mol of the acid equivalent of component (A). That is, the composition for liquid oral cavity of the present invention has a low content of polyvalent metal cation. Since the polyvalent metal cation makes the component (A) insoluble or reduces the effect of removing fine solid products on the tooth surface, the content of the polyvalent metal cation is lowered in order to prevent a decrease in the effect. suppress. The total content of the polyvalent metal cation was measured by ICP emission analysis (ICP emission analysis apparatus: Optima 5300DV, manufactured by Perkin Elmer), and was less than 0.1-fold mol with respect to the acid equivalent amount of component (A). And 0.02 times mol or less is preferable. That is, it is desirable not to add an agent that supplies a polyvalent metal cation such as aluminum, calcium, magnesium, iron, zinc, etc., and it may not contain a polyvalent metal cation unless it is inevitably mixed. Good. In addition, if the above-mentioned polyvalent metal cation is a component containing a polyvalent metal, for example, even if it is an insoluble polyvalent metal salt and exists in the composition as a powder, the effect of the present invention by the component (A) Tend to decrease. For example, even an abrasive powder such as aluminum hydroxide supplies aluminum ions to water in the liquid oral composition. Therefore, when the liquid oral composition of the present invention contains a polyvalent metal salt, a small amount of cations are supplied to the water contained in the liquid oral composition, or the polyvalent metal salt and component (A) It is considered that the component (A) adsorbs the component (A) even by the contact of the component (A), thereby deteriorating the dirt removing performance due to the component (A).

  In the composition for liquid oral cavity of the present invention, a polyvalent cation other than a polyvalent metal such as a cationic surfactant and a cationic antibacterial agent other than the polyvalent metal cation, and an adsorbent such as zeolite and activated carbon are components ( A) may become insoluble, which may lead to a reduction in the removal effect of the solid product deposited on the teeth. Therefore, the total content of polyvalent cations other than polyvalent metals such as one or more cationic antibacterial agents selected from these, and adsorbents such as zeolite and activated carbon is determined by the solid product deposited on the teeth. From the viewpoint of suppressing a reduction in the removal effect, it is preferably less than 0.001% by mass, more preferably 0.0001% by mass or less, and unavoidably mixed in the liquid oral composition of the present invention. Except in the case where it does, what does not contain polyvalent cations other than polyvalent metals, such as a cationic antibacterial agent, and adsorbents, such as a zeolite and activated carbon, is further more preferable.

  In addition, the liquid oral composition of the present invention includes a fluoride ion supply compound such as sodium fluoride, potassium fluoride, and ammonium fluoride, sodium monofluorophosphate, and the like within a range that does not impair the coloring suppression effect of component (A). One or two or more fluorides of the fluorine-containing compound may be contained. These fluorides are not contained in the composition, or the total content of fluoride is preferably less than 500 ppm in terms of fluorine atoms, more preferably 300 ppm or less in terms of fluorine atoms, It is more preferably 200 ppm or less in terms of conversion, and even more preferably 100 ppm or less in terms of fluorine atoms.

  The liquid oral composition of the present invention has a pH of 5.5 or more and 7 or less. In this way, by adjusting the pH of the liquid oral cavity composition within a limited weakly acidic region, when the composition is applied to the oral cavity, the inorganic soil and Effectively works on mixed soils of inorganic and organic soils, removes minute solid products due to deposition of ingredients in saliva, and suppresses demineralization of the tooth surface to exert an excellent whitening effect In addition, it is possible to effectively remove colored stains attached by eating and drinking. The pH of the liquid oral cavity composition of the present invention is 5.5 or more, and further 5.7 or more from the viewpoint of effectively removing colored stains attached by eating and drinking while providing a whitening effect to whiten teeth. It is preferable that the component (A), the component (B), and the component (C) are combined with each other, and from the viewpoint of sufficiently achieving the effect of removing colored stains on the teeth, it is 7 or less, and 6.5 or less. Preferably, it is more preferable to set it as 6.3 or less. In addition, pH in this invention is the value measured without diluting at 25 degreeC.

  The liquid oral composition of the present invention preferably contains 70% by mass or more and 99.8% by mass or less of water. Thereby, the coloring dirt removal effect can be enhanced up to the gap between the teeth while the components (A), (B) and (C) are dissolved well. The liquid oral composition of the present invention is preferably impregnated into a sheet material such as a non-woven fabric, and toothpaste is performed by wiping teeth with a sheet material impregnated with the liquid oral composition, a so-called toothpaste sheet. As described above, since the composition contains a sufficient amount of water, the sheet material can be easily impregnated and used as a toothpaste sheet having a sufficient impregnation rate. The water content in the composition for liquid oral cavity of the present invention is preferably 70% by mass or more, more preferably 75% by mass or more, preferably 99.8% by mass or less, more preferably 99%. 0.7 mass% or less, more preferably 99.5 mass% or less. The water content in the liquid oral composition of the present invention is preferably 70% by mass or more and 99.8% by mass or less, more preferably 75 to 99.7% by mass, and still more preferably. It is 75-99.5 mass%.

  The liquid oral composition of the present invention further improves the stability of the component (A), the component (B), and the component (C), and further imparts a good feel and flavor when applied to the oral cavity. It is preferable to contain alcohol. Examples of the sugar alcohol include erythritol, sorbitol, xylitol, lactitol, reduced palatinose, maltitol and the like, and one or more selected from these are preferable. Among these sugar alcohols, one or more selected from erythritol, xylitol, and sorbitol are preferable from the viewpoint of imparting an appropriate refreshing feeling and wettability.

  The content of the sugar alcohol is preferably 0.5% by mass or more, more preferably in the liquid oral composition of the present invention, from the viewpoint of imparting a good feel and flavor when applied to the oral cavity. It is 1 mass% or more, More preferably, it is 2 mass% or more. The content of the sugar alcohol is preferably 15% by mass or less, more preferably 10% by mass or less, and still more preferably 8%, from the viewpoint of the solubility of the sugar alcohol in water and the flavor when in the oral cavity. It is below mass%.

  The liquid oral composition of the present invention is a hydroxyalkyl cellulose such as hydroxyethyl cellulose, hydroxypropyl cellulose, pullulan, agar, xanthan gum, carboxymethyl cellulose sodium, carrageenan, sodium polyacrylate, tragacanth gum, as long as the effects of the present invention are not impaired. Viscosity of the composition for liquid oral cavity preferably contains one or more gelling agents selected from arabic gum, guar gum, karaya gum, locust bean gum, gela gum, tamarind gum, psyllium seed gum and pectin From the viewpoints of ease of adjusting the feel and feel, and from the viewpoint of moderate thickness and smooth use feeling, a gelling agent selected from hydroxyalkyl cellulose and pullulan is preferable. The content of these gelling agents is such that when the composition for liquid oral cavity of the present invention is applied to the oral cavity, the viscosity is such that almost no thickening or stickiness (viscosity) is felt, and the use feeling is smooth. In the liquid oral composition of the present invention, it is preferably 0.01% by mass or more, more preferably 0.1% by mass, from the viewpoint of exerting a whitening effect on teeth and not inhibiting the effect of removing colored stains on teeth. % Or more, preferably 2% by mass or less, more preferably 1% by mass or less. In addition, the above-mentioned smooth feeling of use refers to the feeling that the liquid oral composition does not feel the sticking to the oral mucosa and does not feel the viscosity of the composition itself. The above-mentioned thickness refers to the liquid oral composition. It refers to the stickiness and viscosity of the composition, and how the composition slowly moves and feels when it flows down.

  The liquid oral cavity composition of the present invention appropriately contains, for example, a pH adjuster, a surfactant, a bactericide, a medicinal component, a pigment, a dye, a fragrance, etc., in addition to the above components, as long as the effects of the present invention are not impaired. Can be made. Further, polyethylene glycol, propylene glycol, glycerin and the like can be contained for the purpose of a wetting agent or a thickening agent.

  In order to adjust the pH of the liquid oral cavity composition of the present invention to 5.5 to 7, it is preferable to use a pH adjuster, and as the pH adjuster, the effect of removing minute solid products by component (A) As long as the decalcification of teeth can be suppressed, organic acids such as acetic acid, fumaric acid, malic acid, lactic acid, gluconic acid, tartaric acid, or salts thereof, phosphoric acid or salts thereof other than phytic acid and pyrophosphoric acid, Examples include inorganic acids such as hydrochloric acid and sulfuric acid, hydroxides such as sodium hydroxide, ammonia or aqueous ammonia, lower alkanolamines, basic amino acids such as arginine and lysine, and the like. These may be used alone or in combination of two or more. You may use it in combination. Among these pH adjusters, the organic acid and inorganic acid (excluding phytic acid and pyrophosphoric acid) are preferably acids selected from malic acid, citric acid and phosphoric acid, and more preferably phosphoric acid having a buffering capacity. Moreover, sodium hydroxide is preferable as a pH adjuster that weakens the pH of acidic phytic acid.

  The composition for liquid oral cavity of the present invention can contain a surfactant. As the surfactant, a nonionic surfactant is preferable from the viewpoint of the stability of the composition, and from the viewpoint of dissolution and dispersibility of the fragrance and the medicinal component. Examples of such nonionic surfactants include polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 40 to 100 moles, an alkyl chain length of 16 to 18 carbon atoms, and an average addition mole number of ethylene oxide of 10 1 type, or 2 or more types selected from -40 mol polyoxyethylene alkyl ether is preferable. The content of the nonionic surfactant in the liquid oral composition of the present invention is preferably 0.2% by mass or more, more preferably 0.3% by mass or more, and preferably 1.2% by mass. Or less, more preferably 1.0% by mass or less.

  The liquid oral composition of the present invention can be applied to a mouthwash, liquid dentifrice, water dentifrice, mouse spray, mouthwash, etc., and the liquid oral composition of the present invention can be used as a sheet. It is also possible to apply to impregnated toothpaste sheets. Especially, it is preferable to set it as a mouthwash, a liquid dentifrice, and a toothpaste sheet. In addition, the liquid oral composition of the present invention is applied to the oral cavity, and not only removes colored stains attached to the tooth by eating and drinking, but also a fine solid formed on the tooth surface and enamel trabecular space. Since the product can be removed, it can also be used as a cleaning agent for whitening teeth. When the composition for liquid oral cavity of the present invention is a mouthwash or a liquid dentifrice, it is preferably applied to the oral cavity 1 to 5 times a day, for example, 5 ml to 100 ml, more preferably 10 ml to It is preferably used by containing 50 ml in the oral cavity. The time included in the oral cavity is preferably 10 seconds to 10 minutes, more preferably 20 seconds to 3 minutes, and even more preferably 30 seconds to 1 minute. When the liquid oral composition of the present invention is applied to a toothpaste sheet, the dirt on the teeth can be removed by wrapping the wet sheet around the fingers and wiping the surface of the teeth.

In relation to the embodiment described above, the present invention further discloses the following liquid oral composition and toothpaste sheet.
[1] The following components (A), (B) and (C):
(A) Phytic acid or its salt 0.01 mass% or more and 3 mass% or less in acid conversion amount,
(B) pyrophosphoric acid or a salt thereof containing 0.01% by mass to 3% by mass in terms of sodium salt, and (C) phenoxyethanol containing 0.1% by mass to 1% by mass and containing no polyvalent metal cation Or a composition for liquid oral cavity containing less than 0.1 times mol with respect to component (A) and having a pH of 5.5 or more and 7 or less.

[2] The content of the component (A) is an acid conversion amount, preferably 0.05% by mass or more, more preferably 0.1% by mass or more, and further preferably 0.2% by mass or more. Yes, preferably 1.5% by mass or less, more preferably 1% by mass or less, and even more preferably 0.7% by mass or less, the liquid oral composition according to the above [1].
[3] The content of component (B) is, in terms of sodium salt, preferably in the amount of sodium salt in the liquid oral composition of the present invention, from the viewpoint of enhancing the performance of removing colored stains attached to teeth by eating and drinking. 05 mass% or more, more preferably 0.1 mass% or more, preferably 1.5 mass% or less, more preferably 1 mass% or less, and even more preferably 0.7 mass% or less. The liquid composition for oral cavity according to [1] or [2] above.

[4] The mass ratio (B / A) of the sodium salt equivalent of component (B) and the acid equivalent of component (A) is preferably 0.1 or more, more preferably 0.2 or more. More preferably, it is 0.4 or more, preferably 7 or less, more preferably 5 or less, further preferably 4 or less, and still more preferably 3 or less, [1] to [3] Any one composition for liquid oral cavity.
[5] The sum of the acid equivalent amount of component (A) and the sodium salt equivalent amount of component (B) is preferably 0.02% by mass or more, more preferably 0.1% by mass or more, and still more preferably. Is 0.2% by mass or more, more preferably 0.5% by mass or more, preferably 5% by mass or less, more preferably 3% by mass or less, and further preferably 1% by mass or less. The liquid composition for oral cavity according to any one of the above [1] to [4].

[6] The content of the component (C) is preferably 0.2% by mass or more, more preferably 0.3% by mass or more, preferably 0.7% by mass or less, and more preferably 0%. The liquid composition for oral cavity according to any one of the above [1] to [5], which is 5% by mass or less.
[7] The mass ratio ((B + C) / A) of the total amount of the sodium salt equivalent of component (B) and the content of component (C) to the acid equivalent amount of component (A) is preferably 0.5. Or more, more preferably 1 or more, still more preferably 1.5 or more, preferably 15 or less, more preferably 12 or less, still more preferably 10 or less, and even more preferably 6 The liquid composition for oral cavity according to any one of [1] to [6] above.
[8] The mass ratio (C / (A + B)) between the content of component (C) and the total amount of acid equivalent of component (A) and sodium salt equivalent of component (B) is preferably 0.1. Or more, more preferably 0.4 or more, still more preferably 0.5 or more, preferably 2 or less, more preferably 1.5 or less, still more preferably 1 or less, more More preferably, the liquid composition for oral cavity according to any one of the above [1] to [7], which is 0.9 or less.

[9] The total content of the polyvalent metal cation is preferably 0.02 times mol or less with respect to the acid equivalent amount of the component (A), and more preferably does not contain the polyvalent metal cation. [8] The composition for liquid oral cavity of any one.
[10] The total content of polyvalent cations other than polyvalent metals such as cationic antibacterial agents and adsorbents such as zeolite and activated carbon is preferably less than 0.001% by mass, and 0.0001% by mass or less. Or a liquid according to any one of the above [1] to [9], which preferably does not contain a polyvalent cation other than a polyvalent metal such as a cationic antibacterial agent, and an adsorbent such as zeolite and activated carbon. Oral composition.

[11] The total content of one or more fluorides selected from a fluorine ion supply compound and a fluorine-containing compound is preferably less than 500 ppm in terms of fluorine atoms, and is 300 ppm or less in terms of fluorine atoms. More preferably, it is more preferably 200 ppm or less in terms of fluorine atoms, still more preferably 100 ppm or less in terms of fluorine atoms, or preferably any one of the above [1] to [10] not containing fluoride. 1. Liquid oral composition.
[12] The pH of the liquid oral cavity composition of the present invention is preferably 5.7 or higher, preferably 6.5 or lower, and more preferably 6.3 or lower. [11] Any one composition for liquid oral cavity.
[13] The content of water in the composition for liquid oral cavity of the present invention is preferably 70% by mass or more, more preferably 75% by mass or more, and preferably 99.8% by mass or less. The liquid oral composition according to any one of [1] to [12], which is preferably 99.7% by mass or less, and more preferably 99.5% by mass or less.

[14] Preferably, the liquid oral composition according to any one of [1] to [13] above, further containing a sugar alcohol.
[15] The sugar alcohol is preferably one or more selected from erythritol, sorbitol, xylitol, lactitol, reduced palatinose and maltitol, more preferably one or more selected from erythritol, xylitol and sorbitol. [14] The liquid oral cavity composition.
[16] The content of the sugar alcohol is preferably 0.5% by mass or more, more preferably 1% by mass or more, still more preferably 2% by mass or more, and preferably 15% by mass or less. More preferably, it is 10 mass% or less, More preferably, it is 8 mass% or less, The liquid oral cavity composition of said [14] or [15].

[17] The liquid oral composition according to any one of [1] to [16], preferably further containing a gelling agent.
[18] The gelling agent is preferably a hydroxyalkyl cellulose such as hydroxyethyl cellulose or hydroxypropyl cellulose, pullulan, agar, xanthan gum, sodium carboxymethyl cellulose, carrageenan, sodium polyacrylate, tragacanth gum, gum arabic, guar gum, caraya gum, locust bean The liquid oral cavity of [17] above, which is one or more selected from gum, gela gum, tamarind gum, psyllium seed gum and pectin, more preferably one or more selected from hydroxyalkyl cellulose and pullulan Composition.
[19] The content of the gelling agent is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, preferably 2% by mass or less, more preferably 1% by mass or less. The liquid composition for oral cavity according to the above [17] or [18].

[20] In adjusting the pH, it is preferable to use a pH adjuster, and the pH adjuster is preferably an acid selected from malic acid, citric acid and phosphoric acid, more preferably phosphoric acid, and preferably water. The liquid oral composition according to any one of the above [1] to [19], which is sodium oxide.
[21] Preferably, it further contains a nonionic surfactant, and the nonionic surfactant is preferably a polyoxyethylene hydrogenated castor oil having an average added mole number of ethylene oxide of 40 to 100 moles, and having 16 to 16 carbon atoms. The liquid oral cavity according to any one of [1] to [20] above, which is one or more selected from polyoxyethylene alkyl ethers having an alkyl chain length of 18 and an average added mole number of ethylene oxide of 10 to 40 moles Composition.
[22] The content of the nonionic surfactant is preferably 0.2% by mass or more, more preferably 0.3% by mass or more, preferably 1.2% by mass or less, more preferably 1%. The composition for liquid oral cavity according to the above [21], which is 0.0 mass% or less.
[23] A toothpaste sheet obtained by impregnating a sheet material with any one of the above liquid oral compositions.

  Hereinafter, the present invention will be specifically described based on examples. In addition, unless otherwise indicated in a table | surface, content of each component shows the mass%.

[Examples 1-5, Comparative Examples 1-5]
According to the formulation shown in Table 1 and Table 2, each liquid oral composition was prepared, and the removal performance of colored stains was evaluated according to the following method.

《Creating colored stain model》
As a tooth model, hydroxyapatite powder close to tooth apatite: “HAp” (Bio-Gel HTP, manufactured by BIO-RAD) was used, and the following steps (1) to (5) were performed.
(1) Protein stain adsorption step with albumin: 2.0 g of HAp was immersed in 40 mL of bovine serum albumin 0.5% solution (BSA Wako Pure Chemical Industries, Ltd.) for 1 hour.
(2) HAp washing step: Next, HAp was separated together with albumin solution by a centrifuge (himac CF702, manufactured by HITACHI) under conditions of a maximum centrifugal acceleration of 3000 × g for 10 minutes, and the supernatant was removed. 40 mL of purified water is further added to the HAp after removing the supernatant, and the mixture is stirred for 1 minute with a stirrer (EYELA CuteMixer CM-1000, manufactured by TOKYO RIKAKIKAI). Washing with purified water was performed three times, separating over a period of time and then removing the supernatant.
(3) Coloring step with black tea liquid: After washing with purified water and filtering, the HAp was taken out and immersed in the black tea solution for 1 hour.
(4) HAp washing step: Similar to the washing step (2) above, the supernatant of black tea was removed by a centrifuge and washed with purified water three times.
(5) Drying step: The washed HAp was filtered out and allowed to dry naturally for one day to obtain a colored HAp.
In addition, the tea solution was used by filtering 6 tea bags (Nitto black tea) in 300 mL of hot water for 5 minutes and filtering at room temperature. The filtration of the black tea solution and the filtration of the above (5) were performed by WHATMAN No. 1 filter paper was used. Moreover, the following evaluation was performed within one day after obtaining colored HAp.

<Evaluation of removal of colored stains>
The obtained colored HAp 10 mg was immersed in 1 mL of liquid oral composition for 10 minutes. After 10 minutes, the liquid oral composition dipped in colored Hap was separated with a centrifuge (himac CF702, manufactured by HITACHI) under the conditions of a maximum centrifugal acceleration of 3000 × g for 10 minutes, and the supernatant liquid was 420 nm. The absorbance was measured.
The measurement results of the absorbance are shown in Tables 1 and 2, and the colored stain removal rate was a value (%) converted to 100% as the absorbance of Comparative Example 2 as a reference for the measured absorbance.

<< Evaluation of tooth surface feel and flavor >>
20 ml of the liquid oral composition was contained in the oral cavity for 40 seconds, and the feel and flavor of the tooth surface after vomiting were evaluated by three professional panelists according to the following criteria. Tables 1 and 2 show the evaluation results of the three discussions.
・ Evaluation criteria of the feel when the tooth surface is touched with the tongue 4: The tongue was able to slide smoothly without feeling friction 3: The tongue was able to slide smoothly even though some friction was felt Completed 2: Same as the tooth surface before use 1: Feeling friction and touching the tongue

-Flavor evaluation criteria 4: Good 3: No particular problem 2: Slightly salty 1: Very salty

As shown in Table 1, in Comparative Example 2 containing phytic acid, Comparative Example 3 further containing phenoxyethanol showed no improvement in color removal rate, and in Comparative Example 4 containing sodium pyrophosphate, Furthermore, no improvement in the color removal rate was observed for Comparative Example 5 containing phenoxyethanol. In other words, phenoxyethanol did not improve the color removal effect against phytic acid or sodium pyrophosphate.
On the other hand, compared with Comparative Example 1 containing phytic acid and sodium pyrophosphate, Example 1 containing phytic acid, sodium pyrophosphate and phenoxyethanol showed a marked improvement in the color removal rate.

  As shown in Table 2, the examples of the present invention containing phytic acid, sodium pyrophosphate and phenoxyethanol resulted in a high color removal rate. Moreover, the higher the phenoxyethanol content, the higher the color removal effect was observed.

[Example 6 (Mouth Wash)] Unit: mass%
Phytic acid 0.3
4 sodium pyrophosphate 0.4
Phenoxyethanol 0.5
Erythritol 5.0
Sorbitol solution (70%) 2.5
Maltitol solution (75%) 1.5
Propylene glycol 2.0
Polyoxyethylene hydrogenated castor oil (40) 0.5
Ethanol (95%) 5.0
Sodium hydroxide 0.07
Sucralose 0.006
Fragrance 0.2
Pullulan 0.8
Purified water balance Total 100.0
Evaluation of tooth surface: 4, evaluation of flavor: 4

Claims (6)

The following components (A), (B) and (C):
(A) Phytic acid or its salt 0.01 mass% or more and 3 mass% or less in acid conversion amount,
(B) pyrophosphoric acid or a salt thereof containing 0.01 mass% or more and 0.7 mass% or less in terms of sodium salt, and (C) phenoxyethanol containing 0.1 mass% or more and 0.7 mass% or less,
The mass ratio (C / (A + B)) of the content of the component (C) and the sum of the acid equivalent amount of the component (A) and the sodium salt equivalent amount of the component (B) is 0.1 or more and 0.9 or less. Yes,
A composition for liquid oral cavity which does not contain a polyvalent metal cation or is contained in an amount less than 0.1-fold mol with respect to the component (A) and has a pH of 5.5 or more and 7 or less.   The mass ratio ((B + C)) / A) of the total amount of the component (B) in terms of sodium salt and the content of the component (C) to the amount in terms of acid of the component (A) is 0.5 or more and 15 or less. The liquid oral cavity composition according to claim 1.   The liquid oral composition according to claim 1 or 2, wherein the mass ratio (B / A) of the sodium salt equivalent of component (B) and the acid equivalent of component (A) is 0.1 or more and 7 or less. .   4. The liquid oral cavity according to claim 1, wherein the total amount of the component (A) in terms of acid and the component (B) in terms of sodium salt is 0.02 to 5% by mass. Composition.   The composition for liquid oral cavity according to any one of claims 1 to 4, comprising 70% by mass or more and 99.8% by mass or less of water.   A toothpaste sheet obtained by impregnating a sheet material with the liquid composition for oral cavity according to any one of claims 1 to 5.