JP6266567B2 - Skin care cream and method for preparing the same - Google Patents
Skin care cream and method for preparing the same Download PDFInfo
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- JP6266567B2 JP6266567B2 JP2015141262A JP2015141262A JP6266567B2 JP 6266567 B2 JP6266567 B2 JP 6266567B2 JP 2015141262 A JP2015141262 A JP 2015141262A JP 2015141262 A JP2015141262 A JP 2015141262A JP 6266567 B2 JP6266567 B2 JP 6266567B2
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- skin care
- care cream
- dimethicone
- acid
- proper amount
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- 239000006071 cream Substances 0.000 title claims description 30
- 238000000034 method Methods 0.000 title claims description 9
- 230000003020 moisturizing effect Effects 0.000 claims description 25
- 229940008099 dimethicone Drugs 0.000 claims description 12
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 12
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 12
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 12
- 239000003086 colorant Substances 0.000 claims description 11
- 239000003974 emollient agent Substances 0.000 claims description 11
- 239000003381 stabilizer Substances 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 239000003755 preservative agent Substances 0.000 claims description 9
- 239000008213 purified water Substances 0.000 claims description 9
- 229920006037 cross link polymer Polymers 0.000 claims description 8
- 239000003906 humectant Substances 0.000 claims description 8
- 230000002335 preservative effect Effects 0.000 claims description 8
- 239000002562 thickening agent Substances 0.000 claims description 8
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 7
- 239000003921 oil Substances 0.000 claims description 7
- 235000019198 oils Nutrition 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 6
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims description 6
- 239000000839 emulsion Substances 0.000 claims description 6
- 239000003205 fragrance Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- RMTFNDVZYPHUEF-XZBKPIIZSA-N 3-O-methyl-D-glucose Chemical compound O=C[C@H](O)[C@@H](OC)[C@H](O)[C@H](O)CO RMTFNDVZYPHUEF-XZBKPIIZSA-N 0.000 claims description 5
- 229920002125 Sokalan® Polymers 0.000 claims description 5
- 230000003472 neutralizing effect Effects 0.000 claims description 5
- 239000002304 perfume Substances 0.000 claims description 5
- 239000001993 wax Substances 0.000 claims description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 4
- 229960001631 carbomer Drugs 0.000 claims description 4
- 238000004945 emulsification Methods 0.000 claims description 4
- -1 phenylvinyl Chemical group 0.000 claims description 4
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 3
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 claims description 3
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims description 3
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 claims description 3
- 235000021355 Stearic acid Nutrition 0.000 claims description 3
- 235000019519 canola oil Nutrition 0.000 claims description 3
- 239000000828 canola oil Substances 0.000 claims description 3
- 239000012185 ceresin wax Substances 0.000 claims description 3
- XJNUECKWDBNFJV-UHFFFAOYSA-N hexadecyl 2-ethylhexanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C(CC)CCCC XJNUECKWDBNFJV-UHFFFAOYSA-N 0.000 claims description 3
- 229920002674 hyaluronan Polymers 0.000 claims description 3
- 229960003160 hyaluronic acid Drugs 0.000 claims description 3
- 239000008172 hydrogenated vegetable oil Substances 0.000 claims description 3
- 229940089456 isopropyl stearate Drugs 0.000 claims description 3
- 239000004200 microcrystalline wax Substances 0.000 claims description 3
- 235000019808 microcrystalline wax Nutrition 0.000 claims description 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 3
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 3
- 229960002446 octanoic acid Drugs 0.000 claims description 3
- ZPWFUIUNWDIYCJ-UHFFFAOYSA-N propan-2-yl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(C)C ZPWFUIUNWDIYCJ-UHFFFAOYSA-N 0.000 claims description 3
- 239000008117 stearic acid Substances 0.000 claims description 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 2
- NKJOXAZJBOMXID-UHFFFAOYSA-N 1,1'-Oxybisoctane Chemical compound CCCCCCCCOCCCCCCCC NKJOXAZJBOMXID-UHFFFAOYSA-N 0.000 claims description 2
- WAYINTBTZWQNSN-UHFFFAOYSA-N 11-methyldodecyl 3,5,5-trimethylhexanoate Chemical compound CC(C)CCCCCCCCCCOC(=O)CC(C)CC(C)(C)C WAYINTBTZWQNSN-UHFFFAOYSA-N 0.000 claims description 2
- ABEXEQSGABRUHS-UHFFFAOYSA-N 16-methylheptadecyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC(C)C ABEXEQSGABRUHS-UHFFFAOYSA-N 0.000 claims description 2
- DGSZGZSCHSQXFV-UHFFFAOYSA-N 2,3-bis(2-ethylhexanoyloxy)propyl 2-ethylhexanoate Chemical compound CCCCC(CC)C(=O)OCC(OC(=O)C(CC)CCCC)COC(=O)C(CC)CCCC DGSZGZSCHSQXFV-UHFFFAOYSA-N 0.000 claims description 2
- LWLRMRFJCCMNML-UHFFFAOYSA-N 2-ethylhexyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCC(CC)CCCC LWLRMRFJCCMNML-UHFFFAOYSA-N 0.000 claims description 2
- OPJWPPVYCOPDCM-UHFFFAOYSA-N 2-ethylhexyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(CC)CCCC OPJWPPVYCOPDCM-UHFFFAOYSA-N 0.000 claims description 2
- QWGRWMMWNDWRQN-UHFFFAOYSA-N 2-methylpropane-1,3-diol Chemical compound OCC(C)CO QWGRWMMWNDWRQN-UHFFFAOYSA-N 0.000 claims description 2
- UIVPNOBLHXUKDX-UHFFFAOYSA-N 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate Chemical compound CC(C)(C)CC(C)CCOC(=O)CC(C)CC(C)(C)C UIVPNOBLHXUKDX-UHFFFAOYSA-N 0.000 claims description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 2
- 102000008186 Collagen Human genes 0.000 claims description 2
- 108010035532 Collagen Proteins 0.000 claims description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims description 2
- OQILCOQZDHPEAZ-UHFFFAOYSA-N Palmitinsaeure-octylester Natural products CCCCCCCCCCCCCCCC(=O)OCCCCCCCC OQILCOQZDHPEAZ-UHFFFAOYSA-N 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 2
- 150000001252 acrylic acid derivatives Chemical class 0.000 claims description 2
- 125000005250 alkyl acrylate group Chemical group 0.000 claims description 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 2
- 235000013871 bee wax Nutrition 0.000 claims description 2
- 239000012166 beeswax Substances 0.000 claims description 2
- 229960003237 betaine Drugs 0.000 claims description 2
- PXTQQOLKZBLYDY-UHFFFAOYSA-N bis(2-ethylhexyl) carbonate Chemical compound CCCCC(CC)COC(=O)OCC(CC)CCCC PXTQQOLKZBLYDY-UHFFFAOYSA-N 0.000 claims description 2
- 229940093528 cetearyl ethylhexanoate Drugs 0.000 claims description 2
- 229920001436 collagen Polymers 0.000 claims description 2
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 claims description 2
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 2
- 229940095139 ethylhexyl laurate Drugs 0.000 claims description 2
- GJQLBGWSDGMZKM-UHFFFAOYSA-N ethylhexyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(CC)CCCCC GJQLBGWSDGMZKM-UHFFFAOYSA-N 0.000 claims description 2
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 229940100554 isononyl isononanoate Drugs 0.000 claims description 2
- 229940093629 isopropyl isostearate Drugs 0.000 claims description 2
- 229940060384 isostearyl isostearate Drugs 0.000 claims description 2
- 238000002844 melting Methods 0.000 claims description 2
- 230000008018 melting Effects 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 229940100573 methylpropanediol Drugs 0.000 claims description 2
- 229940057874 phenyl trimethicone Drugs 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- NEOZOXKVMDBOSG-UHFFFAOYSA-N propan-2-yl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OC(C)C NEOZOXKVMDBOSG-UHFFFAOYSA-N 0.000 claims description 2
- 229940074410 trehalose Drugs 0.000 claims description 2
- LINXHFKHZLOLEI-UHFFFAOYSA-N trimethyl-[phenyl-bis(trimethylsilyloxy)silyl]oxysilane Chemical compound C[Si](C)(C)O[Si](O[Si](C)(C)C)(O[Si](C)(C)C)C1=CC=CC=C1 LINXHFKHZLOLEI-UHFFFAOYSA-N 0.000 claims description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 2
- 229920002554 vinyl polymer Polymers 0.000 claims description 2
- 230000002421 anti-septic effect Effects 0.000 claims 1
- 210000003491 skin Anatomy 0.000 description 34
- 239000000499 gel Substances 0.000 description 11
- 239000013068 control sample Substances 0.000 description 7
- 239000000523 sample Substances 0.000 description 7
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000013078 crystal Substances 0.000 description 6
- 238000011156 evaluation Methods 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 3
- 229940100555 2-methyl-4-isothiazolin-3-one Drugs 0.000 description 2
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
- ZCTXEAQXZGPWFG-UHFFFAOYSA-N imidurea Chemical compound O=C1NC(=O)N(CO)C1NC(=O)NCNC(=O)NC1C(=O)NC(=O)N1CO ZCTXEAQXZGPWFG-UHFFFAOYSA-N 0.000 description 2
- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical compound CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229960005323 phenoxyethanol Drugs 0.000 description 2
- 210000000434 stratum corneum Anatomy 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- UXFQFBNBSPQBJW-UHFFFAOYSA-N 2-amino-2-methylpropane-1,3-diol Chemical compound OCC(N)(C)CO UXFQFBNBSPQBJW-UHFFFAOYSA-N 0.000 description 1
- 101150035093 AMPD gene Proteins 0.000 description 1
- HXQDXOBJMWXQFR-UHFFFAOYSA-N CCCCNC(OC#CC)=O.I Chemical compound CCCCNC(OC#CC)=O.I HXQDXOBJMWXQFR-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 229960005188 collagen Drugs 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- GHVNFZFCNZKVNT-UHFFFAOYSA-M decanoate Chemical compound CCCCCCCCCC([O-])=O GHVNFZFCNZKVNT-UHFFFAOYSA-M 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- WSDISUOETYTPRL-UHFFFAOYSA-N dmdm hydantoin Chemical compound CC1(C)N(CO)C(=O)N(CO)C1=O WSDISUOETYTPRL-UHFFFAOYSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
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- 239000008103 glucose Substances 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
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- 150000005846 sugar alcohols Polymers 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
Landscapes
- Cosmetics (AREA)
Description
本発明は、化粧品分野に関し、具体的にはスキンケアクリームに関し、特に高保湿のスキンケアクリーム及びスキンケアクリームの調製方法に関する。 The present invention relates to the field of cosmetics, specifically to a skin care cream, and more particularly to a skin care cream with high moisturization and a method for preparing the skin care cream.
現在、市販の透明ゲルは、見た目の透明さを維持するために、油溶性の保湿成分を添加することができず、故に保湿効果がクリーム処方のものより劣っている。一方、市販のクリームは乳化剤を入れて強く撹拌することで、油（水）滴を水（油）に均一に分散させる。クリームの保湿効果がゲルより優れているが、見た目に透明感がないため、透明のゲルのような爽やかな見た目及び肌感触をユーザに与えることができない。 Currently, commercially available transparent gels cannot be added with an oil-soluble moisturizing component in order to maintain the apparent transparency, and therefore the moisturizing effect is inferior to that of cream formulations. On the other hand, commercially available creams are dispersed uniformly in water (oil) by adding emulsifier and stirring vigorously. Although the moisturizing effect of the cream is superior to that of the gel, it does not have a transparent appearance, so that it cannot give the user a refreshing appearance and skin feel like a transparent gel.
本発明の１つの目的は、上記の解決しようとする技術問題に対し、見た目が透明であり、肌感触が特別であり、保湿効果の高いスキンケアクリームを提供することにある。 One object of the present invention is to provide a skin care cream that has a transparent appearance, a special skin feel, and a high moisturizing effect with respect to the technical problems to be solved.
本発明のもう１つの目的は、上記のスキンケアクリームの調製方法を提供することにある。 Another object of the present invention is to provide a method for preparing the above skin care cream.
上記目的を達成するために、本発明によるスキンケアクリームは、重量百分率で、エチレンジアミン四酢酸が０．０２％〜０．０５％であり、保湿剤が０．５０％〜２０．００％であり、乳化安定剤が１．００％〜８．００％であり、感触改良剤が１．００％〜１０．００％であり、皮膚軟化剤が０〜１０．００％であり、増粘剤が０．１０％〜０．５０％であり、アルコールが１．００％〜３．００％であり、中和剤が適量であり、香料が適量であり、防腐剤が０．０１％〜１．００％であり、着色剤が適量であり、残りが精製水である。ここで、「０〜」の「０」は、含んでいない場合を意味する。 To achieve the above object, the skin care cream according to the present invention is 0.02% to 0.05% ethylenediaminetetraacetic acid and 0.50% to 20.00% humectant in weight percentage, The emulsification stabilizer is 1.00% to 8.00%, the feel improver is 1.00% to 10.00%, the emollient is 0 to 10.00%, and the thickener is 0. .10% to 0.50%, alcohol is 1.00% to 3.00%, neutralizer is proper amount, perfume is proper amount, preservative is 0.01% to 1.00 %, The colorant is in an appropriate amount, and the balance is purified water. Here, “0” of “0” means a case where it is not included.
好ましい実施方式として、本発明の高保湿のスキンケアクリームは、重量百分率で、エチレンジアミン四酢酸が０．０２％〜０．０４％であり、保湿剤が０．５０％〜５．５０％であり、乳化安定剤が１．００％〜４．００％であり、感触改良剤が１．００％〜５．００％であり、皮膚軟化剤が０〜５．００％であり、増粘剤が０．１０％〜０．３０％であり、アルコールが１．００％〜２．００％であり、防腐剤が０．０１％〜１．００％であり、中和剤が適量であり、香料が適量であり、着色剤が適量であり、残りが精製水である。ここで、「０〜」の「０」は、含んでいない場合を意味する。 As a preferred mode of implementation, the highly moisturizing skin care cream of the present invention has a weight percentage of 0.02% to 0.04% ethylenediaminetetraacetic acid and 0.50% to 5.50% moisturizing agent, The emulsion stabilizer is 1.00% to 4.00%, the feel improver is 1.00% to 5.00%, the emollient is 0 to 5.00%, and the thickener is 0. .10% to 0.30%, alcohol is 1.00% to 2.00%, preservative is 0.01% to 1.00%, neutralizer is proper amount, and fragrance is Appropriate amount, colorant is appropriate amount, and the remainder is purified water. Here, “0” of “0” means a case where it is not included.
好ましい実施方式として、本発明の高保湿のスキンケアクリームは、重量百分率で、エチレンジアミン四酢酸が０．０４％〜０．０５％であり、保湿剤が５．５０％〜２０．００％であり、乳化安定剤が４．００％〜８．００％であり、感触改良剤が５．００％〜１０．００％であり、皮膚軟化剤が５．００〜１０．００％であり、増粘剤が０．３０％〜０．５０％であり、アルコールが２．００％〜３．００％であり、防腐剤が０．２０％〜１．００％であり、中和剤が適量であり、香料が適量であり、着色剤が適量であり、残りが精製水である。 As a preferred mode of implementation, the highly moisturizing skin care cream of the present invention is 0.04% to 0.05% ethylenediaminetetraacetic acid and 5.50% to 20.00% moisturizing agent by weight percentage, The emulsification stabilizer is 4.00% to 8.00%, the feel improver is 5.00% to 10.00%, the emollient is 5.00 to 10.00%, and the thickener. Is 0.30% to 0.50%, alcohol is 2.00% to 3.00%, preservative is 0.20% to 1.00%, and a neutralizing agent is an appropriate amount, The fragrance is in an appropriate amount, the colorant is in an appropriate amount, and the remainder is purified water.
好ましくは、保湿剤は、多価アルコール系（例えば、グリセロール、プロピレングリコール、ブチレングリコール、ジプロピレングリコール、ジグリセロール、メチルプロパンジオール、ポリエチレングリコール）、グルコースエステル系（例えば、ＰＰＧ−１０メチルグルコース、ＰＰＧ−２０メチルグルコース、メチルグルセス−１０）、および高分子バイオ化学系（例えば、トレハロース、ベタイン、ヒアルロン酸、コラーゲン）を含む水性保湿剤のうちの１種または複数種を含む。 Preferably, the humectant is a polyhydric alcohol type (eg, glycerol, propylene glycol, butylene glycol, dipropylene glycol, diglycerol, methylpropanediol, polyethylene glycol), glucose ester type (eg, PPG-10 methyl glucose, PPG). -20 methyl glucose, methyl gluces-10), and one or more of aqueous humectants including macromolecular biochemical systems (eg trehalose, betaine, hyaluronic acid, collagen).
好ましくは、乳化安定剤は、溶融点が３０〜６０℃の１種または複数種のミキシングオイルまたは蝋である。ミキシングオイルは、エチルヘキサン酸セチル、水添植物油、ステアリン酸、およびキャノーラ油を含む混合物であり、蝋は、蜜蝋、セレシン蝋、およびミクロクリスタリンワックスのうちの１種または複数種を含む。 Preferably, the emulsion stabilizer is one or more mixing oils or waxes having a melting point of 30-60 ° C. The mixing oil is a mixture comprising cetyl ethylhexanoate, hydrogenated vegetable oil, stearic acid, and canola oil, and the wax comprises one or more of beeswax, ceresin wax, and microcrystalline wax.
好ましくは、感触改良剤は、（ジメチコン／ビニルジメチコン）クロスポリマー構造、ジメチコンクロスポリマー構造、または（ジメチコン／フェニルビニルジメチコン）クロスポリマー構造を有する弾性体である。 Preferably, a texture modifier is an elastic body having a (dimethicone / vinyl dimethicone) crosspolymer structure, dimethicone crosspolymer structure or (dimethicone / phenyl vinyl dimethicone) crosspolymer structure.
好ましくは、皮膚軟化剤は、シクロペンタシロキサン、ジメチコン、フェニルトリメチコン、ステアリン酸イソプロピル、ジカプリリルエーテル、ラウリン酸エチルヘキシル、ステアリン酸エチルヘキシル、イソノナン酸イソノニル、炭酸ジエチルヘキシル、パルミチン酸エチルヘキシル、エチルヘキサン酸セテアリル、トリ（カプリル酸／カプリン酸）グリセリル、トリエチルヘキサノイン、イソステアリン酸イソプロピル、イソステアリン酸イソステアリル、ジ（カプリル酸／カプリン酸）ＰＧ、およびイソノナン酸イソトリデシルのうちの１種または複数種を含む。 Preferably, the emollient is cyclopentasiloxane, dimethicone, phenyltrimethicone, isopropyl stearate, dicaprylyl ether, ethyl hexyl laurate, ethyl hexyl stearate, isononyl isononanoate, diethyl hexyl carbonate, ethyl hexyl palmitate, cetearyl ethyl hexanoate. , Glyceryl tri (caprylic / caprate), triethylhexanoin, isopropyl isostearate, isostearyl isostearate, di (caprylic acid / capric acid) PG, and isotridecyl isononanoate.
好ましくは、増粘剤は、カルボマー、および、（アクリレーツ／アクリル酸アルキル（Ｃ１０−３０））クロスポリマーのうちの１種または複数種を含む。 Preferably, the thickener comprises one or more of carbomers and (acrylates / alkyl acrylate (C10-30)) crosspolymers.
好ましくは、中和剤は、水酸化カリウム、水酸化ナトリウム、トリエタノールアミン、ＡＭＰ、ＡＭＰＤ、及びトロメタミンのうちの１種または複数種を含む。 Preferably, the neutralizing agent comprises one or more of potassium hydroxide, sodium hydroxide, triethanolamine, AMP, AMPD, and tromethamine.
好ましくは、防腐剤は、メチルイソチアゾリノン、フェノキシエタノール、イミダゾリジニルウレア、ブチルカルバミン酸ヨウ化プロピニル、パラベン系、およびＤＭＤＭヒダントインを含む。 Preferably, preservatives include methylisothiazolinone, phenoxyethanol, imidazolidinyl urea, propynyl butylcarbamate iodide, parabens, and DMDM hydantoin.
本発明で使用する着色剤は市販の水溶性着色剤であれば良い。 The colorant used in the present invention may be a commercially available water-soluble colorant.
本発明で使用する香料は当分野でよく使用される香料である。 The perfume used in the present invention is a perfume often used in the art.
本発明はさらに前記スキンケアクリームの調製方法を提供し、該方法は、
（１）エチレンジアミン四酢酸、保湿剤、中和剤を精製水に入れ、８０℃まで加熱し、保温してスタンバイするステップと、
（２）乳化安定剤、皮膚軟化剤、及び感触改良剤を８０℃まで加熱するステップと、
（３）ステップ（２）の混合物をステップ（１）の混合物に入れ、１分間均質化した後、保温して撹拌するステップと、
（４）カルボマーを入れ、均一に撹拌してから冷却するステップと、
（５）５０℃まで冷却し、アルコール、香料、防腐剤、及び着色剤を入れて均一に撹拌するステップと、を含む。
The present invention further provides a method for preparing the skin care cream, the method comprising:
(1) Put ethylenediaminetetraacetic acid, a moisturizing agent and a neutralizing agent in purified water, heat to 80 ° C., keep warm and stand-by;
(2) heating the emulsification stabilizer, emollient, and feel improver to 80 ° C .;
(3) The mixture of step (2) is put into the mixture of step (1), homogenized for 1 minute, and then kept warm and stirred;
(4) adding carbomer, stirring uniformly and then cooling;
(5) Cooling to 50 ° C., and adding alcohol, fragrance, preservative, and colorant and stirring uniformly.
従来技術と比べ、本発明のスキンケアクリームは以下の利点を有する。 Compared with the prior art, the skin care cream of the present invention has the following advantages.
１．独特な見た目及び肌感触を有する。白い「雪結晶」が色付きの透明ゲルに均一に分布しており、肌に塗れば水分が出て「雪結晶」が溶ける効果があり、独特な肌感触を与えるとともに、肌の上に保湿膜を形成させる。 1. Has a unique look and feel. The white “snow crystals” are evenly distributed in the colored transparent gel, and when applied to the skin, the moisture comes out and the “snow crystals” dissolve, creating a unique skin feel and a moisturizing film on the skin. To form.
２．透明のゲルの中に油溶性の保湿成分を添加し、油溶性成分の選別及び特殊の工程によって、油溶性成分が乳状化されることなく、適宜のサイズで均一且つ安定にゲルに分布しており、従来の透明のゲルと比べ、より高い保湿効果を有する。 2. Oil-soluble moisturizing ingredients are added to the transparent gel, and the oil-soluble ingredients are uniformly and stably distributed in an appropriate size without being emulsified by the selection of oil-soluble ingredients and special processes. And has a higher moisturizing effect than a conventional transparent gel.
本発明の製品は透明のゲル状であり、中に雪結晶の形状に類似する白い保湿粒子が懸濁している。塗ることによって、保湿美容ゲルは肌の表面に水分を出し、速やかに肌に吸収される。雪結晶の形状に類似する保湿粒子は肌の温度によって溶け、塗ることによって、肌の上に強力な保湿膜を形成させ、独特の滑らかな感触を与え、強力で長続きする保湿効果を実現する。したがって、ゲルのような爽やかな見た目及び肌感触をそのままに、クリーム系製品の保湿効果も得られる。 The product of the present invention is a transparent gel in which white moisturizing particles resembling the shape of snow crystals are suspended. When applied, the moisturizing beauty gel gives moisture to the surface of the skin and is quickly absorbed by the skin. Moisturizing particles that resemble the shape of snow crystals melt and apply depending on the skin temperature to form a strong moisturizing film on the skin, giving it a unique smooth feel and realizing a strong and long-lasting moisturizing effect. Therefore, the moisturizing effect of the cream-based product can be obtained while maintaining the fresh appearance and skin feel like a gel.
（実施例）
以下は具体的な実施例に合わせて本発明の技術的解決手段についてさらに詳しく説明するが、本発明の保護範囲は以下の実施例に限らない。
(Example)
In the following, the technical solutions of the present invention will be described in more detail according to specific examples, but the protection scope of the present invention is not limited to the following examples.
各成分を以下の表１に示す重量パーセントで計量し、以下の各成分は市販で購入できる。
実施例１〜３のスキンケアクリームの調製方法は、以下のステップを含む。
（１）エチレンジアミン四酢酸、保湿剤（グリセロール、ＰＰＧ−１０メチルグルコース、またはヒアルロン酸）、中和剤（トリエタノールアミン、水酸化カリウム、または水酸化ナトリウム）を精製水に入れ、８０℃まで加熱し、保温してスタンバイするステップと、
（２）乳化安定剤（ミクロクリスタリンワックス、セレシン蝋、または、ミキシングオイル）、皮膚軟化剤（シクロペンタシロキサンまたはステアリン酸イソプロピル）、及び感触改良剤（ＫＳＧ−１５ＡＰ、ＦＢ−９５８６またはＧＩ ＣＤ−９）を８０℃まで加熱するステップと、
（３）ステップ（２）の混合物をステップ（１）の混合物に入れ、１分間均質化した後、保温して撹拌するステップと、
（４）カルボマーを入れ、均一に撹拌してから冷却するステップと、
（５）５０℃まで冷却し、アルコール、香料、防腐剤（メチルイソチアゾリノン、フェノキシエタノール、またはイミダゾリジニルウレア）、及び着色剤を入れて均一に撹拌するステップと、を含む。
ここで、本実施形態では、ミキシングオイルは、エチルヘキサン酸セチル、水添植物油、ステアリン酸、およびキャノーラ油を含む混合物であり、例えば、Ａｚｅｌｉｓ社のＡＺ Ｂｅａｄ Ｗａｘが使用されている。
The method for preparing skin care creams of Examples 1 to 3 includes the following steps.
(1) Put ethylenediaminetetraacetic acid, humectant (glycerol, PPG-10 methylglucose, or hyaluronic acid), neutralizer (triethanolamine, potassium hydroxide, or sodium hydroxide) in purified water and heat to 80 ° C And step to keep warm and stand by,
(2) Emulsifying stabilizer (microcrystalline wax, ceresin wax or mixing oil), emollient (cyclopentasiloxane or isopropyl stearate), and feel improver (KSG-15AP, FB-9586 or GI CD-9) ) To 80 ° C .;
(3) The mixture of step (2) is put into the mixture of step (1), homogenized for 1 minute, and then kept warm and stirred;
(4) adding carbomer, stirring uniformly and then cooling;
(5) Cooling to 50 ° C., and adding alcohol, fragrance, preservative (methylisothiazolinone, phenoxyethanol, or imidazolidinyl urea), and a colorant and stirring uniformly.
Here, in this embodiment, the mixing oil is a mixture containing cetyl ethylhexanoate, hydrogenated vegetable oil, stearic acid, and canola oil. For example, AZ Bead Wax manufactured by Azelis is used.
調製し得た本実施例１〜３のスキンケアクリームは、クリーム中に白い「雪結晶」が均一に分布している透明ゲルであり、肌に塗れば水分が出て「雪結晶」が溶ける効果があり、独特な肌感触を与えるとともに、肌の上に保湿膜を形成させる。長期間貯蔵試験（室温において３年）及び繰り返し耐熱（４０±１℃、２４時間経て室温に戻った後、濁りがない）、耐寒（−１５±１℃、２４時間経て室温に戻った後、状態が正常で、濁りがない）破壊性試験により、製品の各体感指標、物理化学的指標、衛生指標はいずれも国家基準に適合する。 The prepared skin care creams of Examples 1 to 3 are transparent gels in which white “snow crystals” are uniformly distributed in the cream, and when applied to the skin, moisture is released and the “snow crystals” are dissolved. There is a unique skin feel and a moisturizing film is formed on the skin. Long-term storage test (3 years at room temperature) and repeated heat resistance (40 ± 1 ° C., after returning to room temperature after 24 hours, no turbidity), cold resistance (−15 ± 1 ° C., after returning to room temperature after 24 hours, According to the destructive test, the product experience index, physicochemical index, and hygiene index all comply with national standards.
（使用効果試験）
１．保湿効果の評価
（１）本発明は実施例１、２、３のスキンケアクリームの保湿性について試験評価を行い、市販の透明ゲルを対照サンプルとする。
（２）被験者：男性２名、女性２５名、平均年齢２５．５±１１．２歳。試験部位：両腕上腕の内側、試験部位を２箇所標記し、ランダムにサンプルエリア及び対照エリアと割り当て、サンプルエリアに試験対象物を塗布し、対照エリアに対照サンプルを塗布する。塗布面積：３ｃｍ×３ｃｍ、塗布量：２ｍｇ／ｃｍ2。
（３）テスト方法：被験者が２０ｍｉｎ安静し、テスト前に乾燥したティッシュで皮膚表面を拭き、試験部位及び対照エリアの塗布前の皮膚角質層の水分量を測り、データを記録してから所定量の試験対象物及び対照サンプルを塗布し、実施例及び対照サンプルを塗布してから３０分間後、１時間後、４時間後、及び８時間後の試験部位の皮膚角質層の水分量を比較させ、関連データを記録する。試験過程において、被験者の上腕を露出させ、リラックスしてテスト状態に置かれる。
（４）試験結果：実施例１、実施例２、実施例３、及び対照サンプルに対してそれぞれ水分テスト試験を行う。データによって、対照サンプルに比べて実施例１、実施例２、実施例３の保湿効果は、より優れており、持続時間も長いと結論付けられる。
(Use effect test)
1. Evaluation of Moisturizing Effect (1) The present invention performs test evaluation on the moisturizing properties of the skin care creams of Examples 1, 2, and 3, and uses a commercially available transparent gel as a control sample.
(2) Subjects: 2 males, 25 females, average age of 25.5 ± 11.2 years. Test sites: Two test sites are marked inside the upper arms of both arms, randomly assigned to the sample area and the control area, the test object is applied to the sample area, and the control sample is applied to the control area. Application area: 3 cm × 3 cm, application amount: 2 mg / cm 2 .
(3) Test method: The subject rests for 20 minutes, wipes the skin surface with a dry tissue before the test, measures the moisture content of the skin stratum corneum before application of the test site and the control area, records the data, and then a predetermined amount. The test object and the control sample were applied, and the moisture content of the skin stratum corneum at the test site was compared 30 minutes, 1 hour, 4 hours, and 8 hours after the application of the example and the control sample. Record relevant data. In the course of the test, the upper arm of the subject is exposed and relaxed and placed in the test state.
(4) Test results: A moisture test test is performed on each of Example 1, Example 2, Example 3, and the control sample. From the data, it can be concluded that the moisturizing effect of Example 1, Example 2 and Example 3 is better and the duration is longer than the control sample.
２．肌感触評価試験
（１）本発明は実施例１、２、３のスキンケアクリームの肌感触について試験評価を行い、市販のサンプルＡ（クリーム）を対照例とする。
（２）被験者：保湿クリームをよく使用する女性３０名、平均年齢２５±３歳。試験部位：両腕上腕の内側、試験部位を２箇所標記し、ランダムにサンプルエリア及び対照エリアと割り当て、サンプルエリアに試験対象物を塗布し、対照エリアに対照サンプルを塗布する。塗布面積：３ｃｍ×３ｃｍ、塗布量：２ｍｇ／ｃｍ2。
（３）テスト方法：、テスト前に乾燥したティッシュで皮膚表面を拭き、実施例及び市販のサンプルＡを直接塗布し、塗布感覚を比較する。ランク付けは以下の通りである。５＝感触が特別で、非常に好む、４＝感触が特別で、とても好む、３＝感触が特別で、好む、２＝感触が普通、１＝好まない、０＝非常に好まない。
（４）試験結果：３０名の被験者の使用後の評価に対してデータを記録し、平均値を取って（以下の表２に示す）分析により結論を出す。市販のサンプルＡと比べ、実施例１、実施例２、実施例３のスキンケアクリームは肌感触が特別且つなめらかで、被験者は該スキンケアクリームの感触を好んでいる。
2. Skin Feel Evaluation Test (1) The present invention performs test evaluation on the skin feel of the skin care creams of Examples 1, 2, and 3, and uses a commercially available sample A (cream) as a control example.
(2) Subjects: 30 women who often use moisturizing cream, average age 25 ± 3 years old. Test sites: Two test sites are marked inside the upper arms of both arms, randomly assigned to the sample area and the control area, the test object is applied to the sample area, and the control sample is applied to the control area. Application area: 3 cm × 3 cm, application amount: 2 mg / cm 2 .
(3) Test method: The skin surface is wiped with a dry tissue before the test, the examples and the commercially available sample A are directly applied, and the feeling of application is compared. The ranking is as follows. 5 = special feel, very fond 4 = feel special, very fond 3 = feel special, fond 2 = feel normal, 1 = dislike, 0 = very dislike
(4) Test results: Data are recorded for the evaluation after use of 30 subjects, and an average value is taken (shown in Table 2 below) to conclude by analysis. Compared to the commercially available sample A, the skin care creams of Examples 1, 2 and 3 have a special and smooth skin feel, and the subjects prefer the feel of the skin care cream.
Claims (4)
前記乳化安定剤は、溶融点が３０〜６０℃の１種または複数種のミキシングオイルまたは蝋であり、
前記ミキシングオイルは、エチルヘキサン酸セチル、水添植物油、ステアリン酸、およびキャノーラ油のうちの１種または複数種であり、
前記蝋は、蜜蝋、セレシン蝋、および、ミクロクリスタリンワックスのうちの１種または複数種であり、
前記感触改良剤は、（ジメチコン／ビニルジメチコン）クロスポリマー構造、ジメチコンクロスポリマー構造、または（ジメチコン／フェニルビニルジメチコン）クロスポリマー構造を有する弾性体であり、
前記皮膚軟化剤は、シクロペンタシロキサン、ジメチコン、フェニルトリメチコン、ステアリン酸イソプロピル、ジカプリリルエーテル、ラウリン酸エチルヘキシル、ステアリン酸エチルヘキシル、イソノナン酸イソノニル、炭酸ジエチルヘキシル、パルミチン酸エチルヘキシル、エチルヘキサン酸セテアリル、トリ（カプリル酸／カプリン酸）グリセリル、トリエチルヘキサノイン、イソステアリン酸イソプロピル、イソステアリン酸イソステアリル、ジ（カプリル酸／カプリン酸）ＰＧ、および、イソノナン酸イソトリデシルのうちの１種または複数種であり、
前記増粘剤は、カルボマー、および、（アクリレーツ／アクリル酸アルキル（Ｃ１０−３０））クロスポリマーのうちの１種または複数種であり、
前記保湿剤は、グリセロール、プロピレングリコール、ブチレングリコール、ジプロピレングリコール、ジグリセロール、メチルプロパンジオール、ポリエチレングリコール、ＰＰＧ−１０メチルグルコース、ＰＰＧ−２０メチルグルコース、メチルグルセス−１０、トレハロース、ベタイン、ヒアルロン酸、およびコラーゲンのうちの１種または複数種であることを特徴とするスキンケアクリーム。 By weight percentage, ethylenediaminetetraacetic acid is 0.02% to 0.05%, humectant is 0.50% to 20.00%, and emulsion stabilizer is 1.00% to 8.00%. The feel improver is 1.00% to 10.00%, the emollient is 0 to 10.00%, the thickener is 0.10% to 0.50%, and the alcohol is 1.%. 00% to 3.00%, an appropriate amount of neutralizing agent, an appropriate amount of fragrance, an antiseptic is 0.01% to 1.00%, an appropriate amount of colorant, and the remainder is purified water A highly moisturizing skin care cream characterized by
The emulsion stabilizer is one or a plurality of mixing oils or waxes having a melting point of 30 to 60 ° C.
The mixing oil is one or more of cetyl ethylhexanoate, hydrogenated vegetable oil, stearic acid, and canola oil,
The wax is one or more of beeswax, ceresin wax, and microcrystalline wax,
The feel improver is an elastic body having a ( dimethicone / vinyl dimethicone) cross polymer structure, a dimethicone cross polymer structure, or a (dimethicone / phenylvinyl dimethicone) cross polymer structure,
The emollients are cyclopentasiloxane, dimethicone, phenyltrimethicone, isopropyl stearate, dicaprylyl ether, ethyl hexyl laurate, ethyl hexyl stearate, isononyl isononanoate, diethyl hexyl carbonate, ethyl hexyl palmitate, cetearyl ethyl hexanoate, tri (Caprylic acid / capric acid) glyceryl, triethylhexanoin, isopropyl isostearate, isostearyl isostearate, di (caprylic acid / capric acid) PG, and one or more of isotridecyl isononanoate,
The thickener is one or more of carbomer and (acrylates / alkyl acrylate (C10-30)) crosspolymer,
The humectant is glycerol, propylene glycol, butylene glycol, dipropylene glycol, diglycerol, methylpropane diol, polyethylene glycol, PPG-10 methyl glucose, PPG-20 methyl glucose, methyl gluces-10, trehalose, betaine, hyaluronic acid, And a skin care cream characterized by being one or more of collagen.
（１）エチレンジアミン四酢酸、保湿剤、中和剤を精製水に入れ、８０℃まで加熱し、保温してスタンバイするステップと、
（２）乳化安定剤、皮膚軟化剤、及び感触改良剤を８０℃まで加熱するステップと、
（３）ステップ（２）の混合物をステップ（１）の混合物に入れ、１分間均質化した後、保温して撹拌するステップと、
（４）カルボマーを入れ、均一に撹拌してから冷却するステップと、
（５）５０℃まで冷却し、アルコール、香料、防腐剤、及び着色剤を入れて均一に撹拌するステップと、を含む、ことを特徴とするスキンケアクリームの調製方法。 A method for preparing a skin care cream according to any one of claims 1 to 3,
(1) Put ethylenediaminetetraacetic acid, a moisturizing agent and a neutralizing agent in purified water, heat to 80 ° C., keep warm and stand-by;
(2) heating the emulsification stabilizer, emollient, and feel improver to 80 ° C .;
(3) The mixture of step (2) is put into the mixture of step (1), homogenized for 1 minute, and then kept warm and stirred;
(4) adding carbomer, stirring uniformly and then cooling;
(5) Cooling to 50 ° C., and adding alcohol, fragrance, preservative, and colorant and stirring uniformly, a method for preparing a skin care cream,
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| CN201410821729.5A CN104473792B (en) | 2014-12-23 | 2014-12-23 | A kind of snow of high moisturizing melts skin cream and preparation method thereof |
| CN201410821729.5 | 2014-12-23 |
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| ITUB20153461A1 (en) * | 2015-09-08 | 2017-03-08 | Novamont Spa | Lipophilic cosmetic compositions containing esters of pelargonic acid |
| CN106265330A (en) * | 2016-08-29 | 2017-01-04 | 杭州千岛湖蓝色天使实业有限公司 | The cream that a kind of wrinkle removing is anti-ageing |
| CN106491442A (en) * | 2016-12-06 | 2017-03-15 | 广州聚禅现代农业研究院有限公司 | A kind of ivory white foundation emulsion containing Amaranthus mangostanus L. polyphenol |
| CN106511134B (en) * | 2016-12-13 | 2019-09-17 | 泉州师范学院 | A kind of astaxanthin facial mask nutrient solution and preparation method thereof |
| CN106619301B (en) * | 2016-12-29 | 2019-11-15 | 广州市科能化妆品科研有限公司 | A kind of composition and preparation method thereof containing flakes particle |
| CN107411991B (en) * | 2017-08-21 | 2020-07-31 | 广州神采化妆品有限公司 | Instant-to-apply ice cream and preparation method thereof |
| CN109363993A (en) * | 2018-11-29 | 2019-02-22 | 四川省中医药科学院 | A one-step homogeneous emulsification cooling molding method and its application |
| CN112294707B (en) * | 2019-07-31 | 2022-07-29 | 太和康美(北京)中医研究院有限公司 | Cream with moisturizing effect and preparation method thereof |
| CN110638670A (en) * | 2019-08-26 | 2020-01-03 | 广州睿新生物科技有限公司 | High-permeability moisturizing composition, skin moisturizer and preparation method |
| CN111084753A (en) * | 2020-01-10 | 2020-05-01 | 佐登妮丝（广州）美容化妆品有限公司 | Spot-fading pen |
| CN111096912B (en) * | 2020-02-14 | 2022-06-07 | 广州艾蓓生物科技有限公司 | Bicontinuous phase type eye and lip makeup remover and preparation method thereof |
| CN114306116A (en) * | 2020-09-29 | 2022-04-12 | 天津金耀药业有限公司 | Skin-brightening cream for sensitive muscles and preparation method thereof |
| CN112402273B (en) * | 2020-12-01 | 2023-10-03 | 金发拉比妇婴童用品股份有限公司 | Cream for improving red buttocks of infants and preparation method of cream |
| CN112675062A (en) * | 2020-12-31 | 2021-04-20 | 彭氏(惠州)实业发展有限公司 | Lasting fragrance type body lotion and preparation method thereof |
| CN112915056B (en) * | 2021-03-16 | 2023-07-11 | 武汉润禾生物医药有限公司 | Mild long-acting moisturizing protective cream and preparation method thereof |
| CN114903838A (en) * | 2021-06-07 | 2022-08-16 | 安婕妤化妆品科技股份有限公司 | Face brightening snow cream and preparation method thereof |
| CN115245471B (en) * | 2021-09-23 | 2023-12-26 | 上海瑾亭化妆品有限公司 | Moisturizing repair face cream and preparation method thereof |
| CN114569508A (en) * | 2022-03-14 | 2022-06-03 | 为美而生(广东)实业控股有限公司 | Moisturizing and skin-moistening facial cream containing collagen components and preparation method thereof |
| CN115475107A (en) * | 2022-09-09 | 2022-12-16 | 广州环亚化妆品科技股份有限公司 | A kind of water-in-oil type skin care cream and preparation method thereof |
| CN116585208B (en) * | 2023-05-10 | 2025-07-11 | 麦吉丽生物科技有限公司 | Moisturizing composition, preparation method and application thereof |
| CN117482028B (en) * | 2024-01-03 | 2024-05-07 | 珠海博御中医药研究有限公司 | Long-acting moisturizing emulsion and preparation method thereof |
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| GB9604673D0 (en) * | 1996-03-05 | 1996-05-01 | Procter & Gamble | Skin care compositions |
| US6548074B1 (en) * | 1999-07-22 | 2003-04-15 | Elizabeth Arden Co., Division Of Conopco, Inc. | Silicone elastomer emulsions stabilized with pentylene glycol |
| DE10221812A1 (en) * | 2002-05-16 | 2003-11-27 | Beiersdorf Ag | Aqueous cosmetic composition useful as a shaving or cleansing agent contains fatty acids or salts, emulsifiers, complexers, waxes and talc |
| US7833541B2 (en) * | 2006-05-01 | 2010-11-16 | Momentive Performance Materials Inc. | Cosmetic compositions utilizing acrylate cross linked silicone copolymer networks |
| CN102648892A (en) * | 2012-05-02 | 2012-08-29 | 广州雅纯化妆品制造有限公司 | Moisturizing cream |
| KR20150013604A (en) * | 2012-05-09 | 2015-02-05 | 다우 코닝 코포레이션 | Composition for application to the skin comprising silsesquioxane resin wax and solid particulate |
| CN104188879A (en) * | 2014-08-05 | 2014-12-10 | 高小娜 | Deep moisturizing vanishing cream |
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| JP2016117703A (en) | 2016-06-30 |
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