JP6284745B2 - Dentifrice - Google Patents

Description

  The present invention relates to a dentifrice.

  Conventionally, it has been known that by adding granules to a dentifrice, the surface of the teeth and the ability to remove dirt between teeth can be enhanced, and various granules are used. For example, Patent Document 1 discloses a dentifrice composition containing granules having a disintegration strength of 10 to 200 g / piece, an average particle size of 50 to 150 μm, and a difference between the 90% particle size and the average particle size of 100 μm or less. Have been described. Patent Document 2 discloses granules having an average particle diameter of 100 to 500 μm and a disintegration strength of 0.1 to 10 g / piece, and granules having an average particle diameter of 20 to 200 μm and a disintegration strength of 10 to 50 g / piece. The composition for oral cavity containing these two types of granules is described, and Patent Document 3 also describes a dentifrice containing three types of granules having different particle sizes.

International Publication No. 2006/003989 JP-A-4-243816 JP 2007-126421 A

  Under these circumstances, due to changes in eating habits and lifestyle habits in recent years, factors causing deterioration of the oral environment are also increasing, so the frequency, mesial lip groove, central ridge and centrifugal lip groove, etc. A wide variety of dirt is firmly attached to the surface of the tooth on which irregularities of various sizes are scattered, and it is in a state where it tends to remain. Since the remaining tooth stains can cause coloring, a dentifrice that can sufficiently remove the tooth stains is strongly desired in order to keep white and beautiful teeth while keeping the oral environment clean.

  However, since the granule described in Patent Document 1 is relatively hard and has a sharp particle size distribution at a constant average particle size, coloring stains are sufficiently present on a part of the tooth surface during normal toothbrushing time. It remains attached without being removed. Further, as described in Patent Document 2 and Patent Document 3, even when a dentifrice using a combination of a plurality of granules having different particle sizes and disintegration strengths is used, slight yellowing tends to remain like a bear. . The coloring stains such as yellowing that remain without being removed by such normal tooth brushing have a problem of giving the impression that yellowing remains on the teeth after brushing. These yellowish colors that remain slightly like bears were apt to be overlooked by the present inventors, such as the size of the tip of a toothbrush, or a cleaning agent (abrasive powder) contained in a dentifrice. It has been found that due to the fact that the size cannot be adequately accommodated, dirt remains attached to the recesses having a specific size on the tooth surface. It was also found that these yellowings could not be removed sufficiently even with a dentifrice containing granules, and the stains still remained after brushing.

  Therefore, the present invention relates to a dentifrice that can effectively remove stains such as plaque and colored stains adhering to the teeth, regardless of the size of the unevenness present on the tooth surface.

  Therefore, the inventors of the present invention have included granules having a specific particle size range satisfying a specific volume ratio, that is, granules having a specific particle size distribution and having a specific disintegration strength. In addition to the dirt adhering to the recess having a specific size that was difficult to remove on the surface of the tooth, it is not only between the teeth but also between the teeth, the frequency band, the mesial lip groove, the central ridge And a dentifrice that can sufficiently remove stains such as plaque and colored stains over the entire tooth where there are many small and uneven portions of various sizes, including the cleft lip groove and the like. .

That is, the present invention has a particle size of 45 μm or more, and the following granules (a1) to (a6):
(A1) Granules having a particle size of 45 μm or more and less than 63 μm (a2) Granules having a particle size of 63 μm or more and less than 90 μm (a3) Granules having a particle size of 90 μm or more and less than 125 μm (a4) Granules having a particle size of 125 μm or more and less than 150 μm (a5) Granules having a particle size of 150 μm or more and less than 180 μm (a6) Granules (A) comprising granules having a particle size of 180 μm or more,
The volume ratio ((a2 + a3 + a4) / a6) of the total content of granules (a2), granules (a3) and granules (a4) to the contents of granules (a6) is 0.5 or more and 2 or less, Volume ratio (a2 / a3) of content of (a2) and granule (a3) is 0.5 or more and 2 or less, and mass ratio (a4 / a3) of content of granule (a4) and granule (a3) is The present invention relates to a dentifrice containing 2% by mass or more and 40% by mass or less of a granule (A) having a granule disintegration strength of 0.5 g or more and 0.1 g / piece or less and 15 g / piece or less.

  According to the dentifrice of the present invention, it is possible to sufficiently remove the dirt adhering to the concave portion having a specific size on the tooth surface, which is difficult to remove with the conventional dentifrice. Therefore, an excellent removal effect can be exerted not only between the teeth but also over the entire surface of the tooth where various irregularities of large and small are scattered, and coloring stains that tend to remain on the surface of a part of the tooth are removed. Can be effectively prevented, and an excellent cleaning feeling can be brought about.

It is a graph which shows the particle size distribution of granule A-1, A-4 to A-7 obtained in Preparation Examples 1 to 3. It is a photograph which shows the tooth | gear of Example 1 by evaluation in the evaluation test 1-1. It is a photograph which shows the tooth | gear of the comparative example 1 in evaluation in the evaluation test 1-1. It is a graph which shows the dirt removal area calculated about Example 1 and comparative example 2 in evaluation test 1-2. It is a photograph which shows the tooth | gear of Example 1 by evaluation in the evaluation test 1-2. It is a photograph which shows the tooth | gear of the comparative example 1 in evaluation in the evaluation test 1-2. It is a figure which shows the unevenness | corrugation of the actual tooth | gear which measured the unevenness | corrugation of the tooth | gear with the microscope (One shot 3D, Keyence Corporation make).

Hereinafter, the present invention will be described in detail.
The dentifrice of the present invention has a particle size of 45 μm or more, and the following granules (a1) to (a6):
(A1) Granules having a particle size of 45 μm or more and less than 63 μm (a2) Granules having a particle size of 63 μm or more and less than 90 μm (a3) Granules having a particle size of 90 μm or more and less than 125 μm (a4) Granules having a particle size of 125 μm or more and less than 150 μm (a5 ) Granules having a particle size of 150 μm or more and less than 180 μm (a6) Granules (A) composed of granules having a particle size of 180 μm or more, and the total content of the granules (a2), granules (a3), and granules (a4) The volume ratio ((a2 + a3 + a4) / a6) to the content of granules (a6) is 0.5 or more and 2 or less, and the volume ratio (a2 / a3) of the contents of granules (a2) and granules (a3) is 0.5 to 2 and the mass ratio (a4 / a3) of the content of the granules (a4) and granules (a3) is 0.5 to 2 and the disintegration strength of the granules is 0.1 g / piece Granules (A) of 15 g / piece or more Containing 2% by mass or more and 40% by mass or less, a concave portion having a specific size on the tooth surface that cannot be sufficiently removed by a dentifrice containing conventional granules, specifically, for example, a width of 20 μm As a result, it is possible to effectively remove the dirt that penetrates and adheres to the recesses of 100 μm or less, and it is possible to prevent the colored dirt from being deposited. In addition, since the diameter of the bristle tip of a toothbrush is about 200 micrometers normally and the average particle diameter of the powder abrasive | polishing agent contained in a dentifrice is 5-13 micrometers, the width | variety in the surface of a tooth | gear is 20 micrometers or more and 100 micrometers or less The tip of the bristle cannot penetrate, and the powder abrasive is difficult to reach these recesses, or the frictional force cannot be increased with the tooth surface, resulting in a width of 20 μm to 100 μm. The present inventors paid attention to the fact that dirt tends to remain in the following recesses, and came to find the dentifrice of the present invention.
In addition, even with conventional dentifrices, although there was a slight yellowish part, the surface of the teeth was smooth (feeling of cleaning), but after brushing, a very slight amount of dirt that appears to be yellowish There was a tendency that it was not possible to sufficiently avoid the deposition of dirt, especially in However, with the dentifrice of the present invention, it is possible to effectively remove even the slight remaining yellow, so that it is possible to effectively prevent the deposition of dirt. In other words, it can effectively remove even dirt attached to the unevenness of about 20 μm that can be felt by a person's tongue, so immediately after brushing, while feeling the surface of an extremely smooth tooth that cannot be felt until now, In addition, it is possible to effectively maintain the feeling that the tooth surface is smooth for a long time.

  Granule (A) has a particle size of 45 μm or more, and is composed of granules (a1) to (a6), and these granules retain a specific content. That is, the granule (A) contained in the dentifrice of the present invention has a specific particle size distribution. Specifically, the volume ratio ((a2 + a3 + a4) / a6) of the total content of granules (a2), granules (a3) and granules (a4) to the content of granules (a6) is 0.5 or more and 2 The volume ratio (a2 / a3) of the contents of granules (a2) and granules (a3) is 0.5 or more and 2 or less, and the volume ratio of the contents of granules (a4) and granules (a3) ( a4 / a3) is 0.5 or more and 2 or less. The particle size distribution of such granules (A) conveys to the granules the content of granules having a particle size of 63 μm or more and less than 150 μm, which is an effective size for removing stains on recesses having a width of 100 μm or less, and the bristles of toothbrushes. The content of the granules having a particle size of 180 μm or more effective for the above is a volume ratio of 0.5 or more and 2 or less (1: 2 to 2: 1), that is, these granules are contained in the same amount, Moreover, it has a broad peak in the particle size range of 63 μm or more and less than 180 μm.

  Thus, in the dentifrice of the present invention, granules (a2) to (a4) having a particle size of 63 μm or more and less than 150 μm are present in an appropriate amount, and small granules (a1) having a particle size of 45 μm or more and less than 63 μm are present. ), There are also granules (a5) having a particle size of 150 μm or more and less than 180 μm and large granules (a6) having a particle size of 180 μm or more. As described later, the granules have a specific disintegration strength. Combined with this, it effectively removes difficult-to-remove stains adhering to the recesses with a width of 20 μm or more and 100 μm or less on the surface of the teeth, and between teeth, frequency band, mesial lip groove, central ridge and centrifugal lip A wide range of large and small irregularities, including grooves, etc., over the entire tooth area, that is, from the extremely fine recesses to the large recesses that are difficult to reach and clean. It removes dirt effectively and gives a much smoother feel when the teeth are touched with the tongue than a conventional dentifrice containing granules, and maintains a smooth feel for a long time after brushing. An excellent cleaning feeling can be brought about.

  The granule (A) contains a granule (a6) having a particle size of 180 μm or more. The content of the granule (a6) is preferably 20% by volume or more, and more preferably 25% by volume in the granule (A) from the viewpoint of easily transmitting stress from the bristles of the toothbrush to the granule during brushing. From the viewpoint of effectively removing dirt that is difficult to remove and is attached to a recess having a width of 20 μm or more and 100 μm or less, which is more preferably 30% by volume or more and difficult to remove by normal brushing, preferably 52% by volume or less. More preferably, it is 50 volume% or less, More preferably, it is 45 volume% or less. Moreover, content of a granule (a6) becomes like this. Preferably it is 20-52 volume% in a granule (A), More preferably, it is 25-50 volume%, More preferably, it is 30-45 volume%.

  The content of the granule (a1) effectively removes dirt adhering to extremely fine recesses on the tooth surface by the interaction with the granules (a2) to (a6) having a larger particle size. From the viewpoint of obtaining an extremely smooth feel when touched and maintaining such a feel, the content in the granule (A) is preferably 5% by volume or more, more preferably 7% by volume or more. The content of the granule (a1) maintains a good balance with the content of the granules (a2) to (a6) and not only cleans very fine recesses, preferably recesses having a width of 20 μm to 60 μm. From the viewpoint of effectively removing the adhesion dirt on the tooth surface until it reaches a slightly large recess while being entangled with the granules (a2) to (a6), it is preferably 18% by volume or less in the granule (A). More preferably, it is 15 volume% or less, More preferably, it is 12 volume% or less. Moreover, content of a granule (a1) becomes like this. Preferably it is 5-18 volume% in a granule (A), More preferably, it is 7-15 volume%, More preferably, it is 7-12 volume%.

  The content of the granule (a2) is from the viewpoint of effectively removing dirt adhering to a recess having a width of 60 μm or less, preferably 40 μm or more and effectively preventing colored stains adhering firmly. In (A), Preferably it is 7 volume% or more, More preferably, it is 9 volume% or more, More preferably, it is 10 volume% or more. The content of the granules (a2) maintains a good balance with the contents of the granules (a1) and the granules (a3) to (a6), ranging from extremely fine recesses to recesses with a width of 60 μm or less. From the viewpoint of effectively removing uneven dirt on the surface of the surface, it is preferably 25% by volume or less, more preferably 20% by volume or less, and further preferably 18% by volume or less in the granule (A). . The content of the granule (a2) is preferably 7 to 25% by volume, more preferably 9 to 20% by volume, and further preferably 10 to 18% by volume in the granule (A).

  The content of the granule (a3) effectively removes dirt adhering to a recess having a width of 100 μm or less, more preferably a recess having a width of 50 μm or more, which could not be sufficiently removed by a conventional dentifrice, and adheres firmly. From the viewpoint of effectively preventing coloring stains and reducing slight yellowing after tooth brushing, the content in the granule (A) is preferably 8% by volume or more, more preferably 9% by volume or more, and still more preferably. Is 10% by volume or more. The content of the granule (a3) maintains a specific volume ratio with the content of the granule (a2) and the granule (a4), and the unevenness on the surface of the tooth is reduced from a very fine recess to a recess having a width of 80 μm or less. From the viewpoint of effectively removing adhered dirt, the content in the granule (A) is preferably 25% by volume or less, more preferably 20% by volume or less, and still more preferably 18% by volume or less. Moreover, content of a granule (a3) becomes like this. Preferably it is 8-25 volume% in a granule (A), More preferably, it is 9-20 volume%, More preferably, it is 10-18 volume%.

The volume ratio (a2 / a3) of the content of the granules (a2) and the content of the granules (a3) is effective from very fine recesses present on the tooth surface to dirt attached to recesses with a width of 80 μm or less. From the viewpoint of removing the fine and deep dirt that is present in the lip groove, etc., and removing the stains on the lip groove, etc. , Preferably 0.7 or more, 2 or less, preferably 1.8 or less, more preferably 1.6 or less. The volume ratio (a2 / a3) of the content of the granule (a2) and the content of the granule (a3) is 0.5 or more and 2 or less, preferably 0.7 to 1.8, more Preferably it is 0.7-1.6. As described above, the content of the granule (a2) and the content of the granule (a3) are such that the volume ratio is 1: 2 to 2: 1, and these granules have the same amount. It is possible to obtain an impression that even the yellowish surface of the surface is removed.
The fine but deep recess described above refers to a recess whose size is deeper than the width. The deep recess includes a granule having a particle size slightly larger than the width of the recess, and these particle sizes. The presence of large granules and small granules in a balanced manner allows the granules to enter the recesses and remove the dirt attached to the recesses.

  The content of the granules (a4) is a dirt adhering to a recess having a width of 120 μm or less, more preferably a recess having a width of 100 μm or less, more preferably a recess having a width of 70 μm or more, which could not be sufficiently removed by a conventional dentifrice. In the granule (A), it is preferably 7% by volume or more, more preferably 10% by volume or more, and still more preferably, from the viewpoint of effectively removing coloring stains and effectively preventing colored stains that adhere firmly. Is 12% by volume or more. The content of granule (a4) keeps a good balance with the content of granule (a3) and granule (a2), and it is effective for uneven dirt on the tooth surface until it reaches a recess with a width of 120 μm or less From the viewpoint of removal, the content in the granule (A) is preferably 25% by volume or less, more preferably 20% by volume or less, and still more preferably 18% by volume or less. Moreover, content of a granule (a4) becomes like this. Preferably it is 7-25 volume% in a granule (A), More preferably, it is 10-20 volume%, More preferably, it is 12-18 volume%.

  The volume ratio (a4 / a3) of the content of the granules (a4) and the content of the granules (a3) is abundant on the tooth surface, and it is difficult to clean with a powdery abrasive or toothbrush with a width of 120 μm or less Effectively removes dirt adhering to the recesses, effectively removes dirt adhering to deep recesses with a width of 120 μm or less present in the lip groove, etc., and the entire tooth after brushing is extremely white From the viewpoint of obtaining an impression that it has become, it is 0.5 or more, preferably 0.6 or more, more preferably 0.7 or more, 2 or less, and preferably 1.8 or less. More preferably, it is 1.6 or less. The volume ratio (a4 / a3) of the content of the granule (a4) and the content of the granule (a3) is 0.5 or more and 2 or less, preferably 0.6 to 1.8, more Preferably it is 0.7-1.6. As described above, the content of the granule (a4) and the content of the granule (a3) have a volume ratio of 1: 2 to 2: 1 and the same amount. It is possible to obtain an impression that even yellowing is removed.

  The content of the granule (a5) is preferably 2 in the granule (A) from the viewpoint of easily transmitting the stress from the bristle of the toothbrush at the time of brushing with the granule (a6) to the granules (a2) to (a4). It is at least volume%, more preferably at least 5 volume%, even more preferably at least 8 volume%. The content of the granule (a5) is preferably 20% by volume or less in the granule (A) from the viewpoint of effectively removing dirt that is difficult to remove with a toothpaste having a width of 20 μm or more and 100 μm or less that is difficult to remove by normal tooth brushing. More preferably, it is 15 volume% or less. Moreover, content of a granule (a5) becomes like this. Preferably it is 2-20 volume% in a granule (A), More preferably, it is 5-15 volume%, More preferably, it is 8-15 volume%.

  The volume ratio (a5 / a3) of the content of the granules (a5) and the content of the granules (a3) is abundant on the tooth surface, and it is difficult to clean with a powdery abrasive or toothbrush with a width of 120 μm or less. Effectively removes dirt adhering to the recesses, effectively removes dirt adhering to deep recesses with a width of 120 μm or less present in the lip groove, etc., and the entire tooth after brushing is extremely white From the viewpoint of obtaining an impression that it has become, it is preferably 0.4 or more, more preferably 0.5 or more, still more preferably 0.7 or more, preferably 1.5 or less, more preferably 1 or less, more preferably 0.9 or less. Moreover, the volume ratio (a5 / a3) of the content of the granule (a5) and the content of the granule (a3) is preferably 0.4 to 1.5, more preferably 0.5 to 1. More preferably, it is 0.7-0.9. Thus, the content of the granule (a5) is the same as the content of the granule (a3), preferably slightly less, that is, the contents of the granules (a2) to (a4) are contained in the granule (a5). By the same amount or slightly less than the amount, it is possible to obtain an impression that even the yellowing of the tooth surface has been removed after brushing.

In the dentifrice of the present invention, the volume ratio ((a2 + a3 + a4) / a6) of the total content of granules (a2), granules (a3) and granules (a4) to the content of granules (a6) is 0.5. It is 2 or less. Since the granules (a2) to (a4) and (a6) have such a volume ratio, the granules (a6) having a particle size of 180 μm or more for transmitting the stress of the bristle of the toothbrush and a size easily pushed into the recesses of 100 μm or less By combining the granule (a2), granule (a3) and granule (a4), it is possible to effectively remove fine dirt adhering to the concave portion having a width of 20 μm or more and 100 μm or less on the tooth surface. From this viewpoint, the total content of the granule (a2), the granule (a3) and the granule (a4) and the content of the granule (a6) are in a volume ratio of 1: 2 to 2: 1. The total content of (a2), granule (a3) and granule (a4) and the content of granule (a6) are the same or the total content of granules (a2) to (a4) The volume ratio ((a2 + a3 + a4) / a6) is preferably 0.7 or more, more preferably 1 or more, preferably 1.8 or less, more preferably 1.5 or less. It is. The volume ratio ((a2 + a3 + a4) / a6) is 0.5 or more and 2 or less, preferably 0.7 to 1.8, and more preferably 1 to 1.5.
Furthermore, the total content of the granules (a2), granules (a3) and granules (a4) is preferably 30% by volume or more, more preferably 35% by volume or more in the granules (A), Preferably it is 40 volume% or more, Preferably it is 60 volume% or less, More preferably, it is 55 volume% or less, More preferably, it is 50 volume% or less.

  The total content of granule (a2), granule (a3), (a4) and granule (a5) is the particle size of granule (a6) having a particle size of 180 μm or more in the dentifrice that transmits the stress of the bristle of the toothbrush. Granule (a5) having a diameter of 150 μm or more and less than 180 μm assists in transmitting the stress of the bristle, and the granules (a2), granules (a3) and granules (a4) combine to form a recess having a width of 20 μm or more and 150 μm or less on the tooth surface. From the viewpoint of effectively removing the attached fine dirt, in the granule (A), preferably 40% by volume or more, more preferably 43% by volume or more, further preferably 48% by volume or more, Preferably it is 70 volume% or less, More preferably, it is 65 volume% or less, More preferably, it is 60 volume% or less.

  In the dentifrice of the present invention, the volume ratio ((a2 + a3 + a4 + a5) / a6) of the total content of granules (a2), granules (a3), granules (a4) and granules (a5) to the contents of granules (a6) ) Is preferably 0.8 or more from the viewpoint of removing dirt firmly adhered to the recesses having a width of 20 μm or more and 150 μm or less on the tooth surface by application of a dentifrice, while slightly larger granules are pushed into the recesses. More preferably, it is 0.9 or more, More preferably, it is 1 or more, More preferably, it is 1.1 or more, Preferably it is 2.5 or less, More preferably, it is 2 or less, More preferably, it is 1 .8 or less.

  In the dentifrice of the present invention, the volume ratio ((a2 + a3 + a4) / a5) of the total content of granule (a2), granule (a3) and granule (a4) to the content of granule (a5) is dentifrice. Is preferably 2.5 or more, more preferably 3 or more, from the viewpoint of removing dirt firmly adhered to the recesses having a width of 20 μm or more and 100 μm or less on the surface of the tooth by being applied with a slightly larger granule than the recesses. More preferably, it is 3.5 or more, preferably 7 or less, more preferably 6 or less, and still more preferably 5 or less.

As described above, since the contents of the granules (a2) to (a6) each have a specific volume ratio, the granules of the present invention contain more than a specific amount of granules having a particle size of 63 μm or more and less than 150 μm. The particle size distribution of (A) has a peak in addition to the average particle size, and the fine particles adhered to the recesses having a width of 20 μm or more and 100 μm or less on the tooth surface where the abrasive powder (cleaning agent) and toothbrush bristle are difficult to reach. This makes it possible to effectively remove dirt. In general, a granule having a specified average particle size is a granule designed to have a normal distribution centered on the average particle size in the particle size distribution, and in such a conventional granule, an abrasive that is a powder It was difficult to remove fine dirt over the entire area of the concave portion in a range where the (cleaning agent) and the toothbrush bristle were difficult to reach. According to the granule (A) of the present invention, even with normal toothbrushing, It is possible to efficiently remove stains adhering to the recesses having a width of 20 μm or more and 100 μm or less that are difficult to remove on the surface, and it is possible to obtain a white impression by removing the yellow spots.
From this point of view, the particle size distribution of the granules (A) has a broad peak or a plurality of peaks in the particle size range of the granules (a2) to (a4), and is different from the average value. It has an uneven distribution with a peak. More specifically, the particle size distribution of the granules (A) is a broad distribution in which the contents of the granules (a2) to (a4) are substantially the same, or the contents of the granules (a2) to the granules (a4) are granules. Distribution with more than the content of (a5) and a plurality of peaks in combination with the peak of granules (a6), and further the content of granules (a2) or granules (a4) contains granules (a1) and (a3) More than the amount, or having a particle size distribution peak within the range of the particle size of the granule (a3), but the total content of the granules (a2) to (a5) is larger than the total amount of (a6) It is preferable to have a particle size distribution peak at a value different from the average value, that is, to have a distribution different from the normal distribution, and the content of granules (a2) to (a4) is almost the same as the content of granules (a5) Broad particle size distribution, or granules (a2) to It is preferable that the content of a4) comprises more particle size distribution than the content of the granules (a5).

  In the dentifrice of the present invention, the disintegration strength of the granule (A) is entangled while exhibiting various particle sizes of large and small by being appropriately disintegrated, and has a width of 100 μm or less that could not be sufficiently removed by conventional dentifrices. From the viewpoint of effectively removing the dirt that has entered and adhered to the recesses of any size on the tooth surface including the recesses of 0.1 g / piece, preferably 0.2 g / piece or more. More preferably, it is 0.5 g / piece or more, 15 g / piece or less, preferably 10 g / piece or less, more preferably 8 g / piece or less. The disintegration strength of the granule (A) of the present invention is 0.1 g / piece or more and 15 g / piece or less, preferably 0.2 to 10 g / piece, more preferably 0.5 to 8 g / piece. It is.

  For the disintegration strength of the granules (A) in the present invention, 10 to 20 granules having a particle size of 180 to 200 μm are extracted from the granules (A), and a micro compression tester (Shimadzu Corporation, MCTM-500) is used. The average value measured by the above method, and the above method is also used by extracting 10 to 20 granules of granules (A2) to (a6), which are granules having a particle size of 63 μm or more. The average value measured by is from 0.1 g / piece to 15 g / piece, preferably from 0.2 to 10 g / piece, more preferably from 0.5 to 8 g / piece.

  As long as the granule (A) is composed of the granules (a1) to (a6) having the above contents and has the above-described disintegration strength, the material and granulation method are not particularly limited, and rolling granulation, extrusion Various granules using known methods such as granulation, compression granulation, crushing granulation, stirring granulation, fluidized bed granulation, spray drying granulation, melt solidification granulation can be used. Specifically, for example, abrasive powders such as calcium carbonate, silica, aluminum hydroxide, and zeolite are used with an organic binder such as wax, paraffin, and stearic acid, or colloidal silica and magnesium aluminate metasilicate. Granules obtained by binding using inorganic binders such as; granules obtained by agglomerating or complexing calcium carbonate fine particles not using binders; gel methods for agglomerating silica, precipitation methods, etc. Examples thereof include granules obtained by a wet method or a spray granulation method.

  The content of the granules (A) is sufficient to effectively remove the adhering dirt without depending on the size of the irregularities on the tooth surface from extremely fine concave parts to larger concave parts. From the viewpoint of exhibiting, the dentifrice of the present invention is 2% by mass or more, preferably 3% by mass or more, and more preferably 5% by mass or more. The content of the granule (A) is 40% by mass or less in the dentifrice of the present invention, preferably from the viewpoint of suppressing the foreign body feeling in the oral cavity while maintaining the excellent effect of the granule (A), preferably It is 25 mass% or less, More preferably, it is 20 mass% or less. The content of the granule (A) is 2% by mass to 40% by mass in the dentifrice of the present invention, preferably 3 to 25% by mass, more preferably 5 to 20% by mass. .

  As a method for preparing the granule (A) having a particle size distribution of the present invention, it can be obtained by sizing into granules in each particle size range and mixing the sized granules appropriately. In the case of a granule that is extremely easy to disintegrate such as a disintegration strength of 15 g / piece or less, for example, a granule having an average particle diameter of 100 to 500 μm is prepared, preferably two or more granules having different average particle diameters are prepared, By mixing these granules with a wetting agent such as glycerin or a viscous base and stirring at an appropriate rotational speed, the granules are crushed. Therefore, the content of granules of less than 150 μm is increased, and the granules of the present invention (A) can also be obtained. The method for producing a dentifrice of the present invention prepares granules having an average particle diameter of 100 to 500 μm, preferably 100 to 300 μm, preferably two or more granules having different average particle diameters, glycerin, sorbitol, A step of adding to a base containing one or more wetting agents selected from propylene glycol and polyethylene glycol, and one or more binders selected from sodium carboxymethylcellulose, xanthan gum, carrageenan and sodium alginate, and granules And a step of stirring at least a part at which the granule is broken and a stirring time. In such a stirring step, the granules are crushed so that the peak or average particle size in the particle size distribution of the obtained dentifrice becomes smaller than that at the time of blending, and the content of granules having a particle size of 63 μm or more and less than 150 μ increases. Will be.

  The water content can be set as appropriate according to the dosage form, etc., but increases the dispersibility of the granules (A) and other components, and adheres to the tooth surface from extremely fine recesses to even larger recesses. In the dentifrice of the present invention, it is preferably more than 0% by mass and more preferably 10% by mass or more from the viewpoint of sufficiently exerting the dirt removing effect. The water content is preferably 60% by mass or less, more preferably in the dentifrice of the present invention, from the viewpoint of efficiently transmitting the load applied by brushing to the granules (A) and causing good disintegration. Is 50 mass% or less. Moreover, the content of water in the dentifrice of the present invention is preferably more than 0% by mass and 60% by mass or less, and more preferably 10 to 50% by mass.

  The water content (moisture content) in the dentifrice of the present invention can be calculated from the blended moisture content and the moisture content in the blended component, but can be measured, for example, with a Karl Fischer moisture meter. . As the Karl Fischer moisture meter, for example, a trace moisture measuring device (Hiranuma Sangyo Co., Ltd.) can be used. In this apparatus, 5 g of dentifrice is taken and suspended in 25 g of anhydrous methanol, and 0.02 g of this suspension is fractionated and the amount of water can be measured.

  The dentifrice of the present invention can further contain an abrasive. In the present invention, the abrasive refers to a powder or granulated product having a particle size of less than 45 μm, and examples thereof include abrasive silica, calcium carbonate, zeolite, calcium phosphate, polyethylene powder, nylon powder, polypropylene powder, and taste and cleaning. From the viewpoint of properties, abrasive silica and calcium carbonate are preferred. As an abrasive | polishing agent, the 1 type (s) or 2 or more types chosen from the above can be used. The content of the abrasive is preferably 5% by mass or more, more preferably 7% by mass or more, and preferably 25% by mass or less in the dentifrice of the present invention from the viewpoint of cleaning performance and usability. More preferably, it is 20 mass% or less. In the dentifrice of the present invention, the total content of the granules (A) and the abrasive is preferably 20% by mass or more, more preferably 25% by mass or more, and preferably 50% by mass or less. More preferably, it is 40 mass% or less, More preferably, it is 30 mass% or less.

  In the dentifrice of the present invention, in addition to the above components, for example, a binder such as sodium alginate, sodium carboxymethylcellulose, carrageenan, xanthan gum; glycerin, sorbitol, propylene glycol, xylitol, Wetting agents such as maltite, lactit, trehalose; sweeteners such as saccharin sodium and aspartame; preservatives such as ethyl paraoxybenzoate; pH adjusters such as phosphoric acid, citric acid, malic acid and their salts; acylamino acid salts, alkyls Anionic surfactants such as phosphate, alkyl sulfate ester salt, fatty acid ester salt, N-methyl long chain acyl taurine sodium salt, polyoxyethylene monoalkyl phosphate; sucrose fatty acid ester, polyoxyethylene hydrogenated castor oil, Poly Nonionic surfactants such as lysine fatty acid ester and sorbitan fatty acid ester and other surfactants; sodium fluoride, tin fluoride, ammonium fluoride, potassium fluoride, lithium fluoride, sodium monofluorophosphate, monofluorophosphate Fluorine ion supply compounds such as potassium and ammonium fluoride; allantoin, tranexamic acid, vitamin E, vitamin C, sodium chloride, sodium fluoride, sodium monofluorophosphate, benzethonium chloride, glycyrrhetinic acid, chlorhexidine, cetylpyridinium chloride, trichlorohydroxy Medicinal components such as phenyl ether (triclosan); perfume and the like can be appropriately contained.

  The dentifrice of the present invention can be various dentifrices such as gel dentifrice, toothpaste and powder dentifrice. In particular, from the viewpoint of fully enjoying the effect of the granules (A) that effectively remove the attached dirt without being influenced by the size of the irregularities on the tooth surface from extremely fine concave parts to larger concave parts, Toothpaste and toothpaste are preferred.

In relation to the embodiment described above, the present invention further discloses the following dentifrice.
[1] The particle size is 45 μm or more, and the following granules (a1) to (a6):
(A1) Granules having a particle size of 45 μm or more and less than 63 μm (a2) Granules having a particle size of 63 μm or more and less than 90 μm (a3) Granules having a particle size of 90 μm or more and less than 125 μm (a4) Granules having a particle size of 125 μm or more and less than 150 μm (a5 ) Granules (A) composed of granules having a particle size of 150 μm or more and less than 180 μm,
The volume ratio ((a2 + a3 + a4) / a6) of the total content of granules (a2), granules (a3) and granules (a4) to the contents of granules (a6) is 0.5 or more and 2 or less, The volume ratio (a2 / a3) of the contents of (a2) and granules (a3) is 0.5 or more and 2 or less, and the volume ratio (a4 / a3) of the contents of granules (a4) and granules (a3) is A dentifrice containing 2% by mass or more and 40% by mass or less of a granule (A) having a granule disintegration strength of 0.5 g or more and 0.1 g / piece or less and 15 g / piece or less.
[2] The content of the granules (a1) in the granules (A) is preferably 5% by volume or more, more preferably 7% by volume or more, preferably 18% by volume or less, more preferably The dentifrice of the above-mentioned [1], which is 15% by volume or less, more preferably 12% by volume or less.
[3] The content of the granules (a2) in the granules (A) is preferably 7% by volume or more, more preferably 9% by volume or more, still more preferably 10% by volume or more, preferably The dentifrice of [1] or [2] above, which is 25% by volume or less, more preferably 20% by volume or less, and further preferably 18% by volume or less.
[4] The content of the granule (a3) in the granule (A) is preferably 8% by volume or more, more preferably 9% by volume or more, still more preferably 10% by volume or more, preferably The dentifrice according to any one of the above [1] to [3], which is 25% by volume or less, more preferably 20% by volume or less, and further preferably 18% by volume or less.

[5] The volume ratio (a2 / a3) of the content of the granule (a2) and the content of the granule (a3) is preferably 0.7 or more, preferably 1.8 or less, more preferably 1 The dentifrice according to any one of [1] to [4] above, which is 6 or less.
[6] The content of the granule (a4) in the granule (A) is preferably 7% by volume or more, more preferably 10% by volume or more, further preferably 12% by volume or more, preferably The dentifrice according to any one of the above [1] to [5], which is 25% by volume or less, more preferably 20% by volume or less, and further preferably 18% by volume or less.
[7] The volume ratio (a4 / a3) of the content of the granule (a4) and the content of the granule (a3) is preferably 0.6 or more, more preferably 0.7 or more, preferably 1 The dentifrice according to any one of the above [1] to [6], which is .8 or less, more preferably 1.6 or less.
[8] The content of the granule (a5) in the granule (A) is preferably 2% by volume or more, more preferably 5% by volume or more, further preferably 8% by volume or more, preferably The dentifrice of any one of [1] to [7] above, which is 20% by volume or less, more preferably 15% by volume or less.

[9] The volume ratio (a5 / a3) of the content of the granule (a5) and the content of the granule (a3) is preferably 0.4 or more, more preferably 0.5 or more, and still more preferably The dentifrice according to any one of the above [1] to [8], which is 0.7 or more, preferably 1.5 or less, more preferably 1 or less, and further preferably 0.9 or less.
[10] The volume ratio ((a2 + a3 + a4) / a6) of the total content of granules (a2), granules (a3) and granules (a4) to the content of granules (a6) is preferably 0.7 or more The dentifrice according to any one of [1] to [9] above, which is more preferably 1 or more, preferably 1.8 or less, and more preferably 1.5 or less.
[11] The total content of the granules (a2), granules (a3) and granules (a4) is preferably 27% by volume or more, more preferably 35% by volume or more in the granules (A). More preferably, it is 40% by volume or more, preferably 60% by volume or less, more preferably 55% by volume or less, and further preferably 50% by volume or less, and any one of [1] to [10] above Dentifrice.
[12] The content of the granule (a6) in the granule (A) is preferably 20% by volume or more, more preferably 25% by volume or more, further preferably 30% by volume or more, preferably The dentifrice according to any one of the above [1] to [11], which is 52% by volume or less, more preferably 50% by volume or less, and further preferably 45% by volume or less.
[13] The volume ratio ((a2 + a3 + a4 + a5) / a6) of the total content of granules (a2), granules (a3), granules (a4) and granules (a5) to the contents of granules (a6) is preferably Is 0.8 or more, more preferably 0.9 or more, still more preferably 1 or more, still more preferably 1.1 or more, preferably 2.5 or less, more preferably 2 The dentifrice of any one of the above-mentioned [1] to [12], which is more preferably 1.8 or less.
[14] The total content of the granules (a2), granules (a3), granules (a4) and granules (a5) is preferably 40% by volume or more, more preferably 43 volumes in the granules (A). % Or more, more preferably 48% by volume or more, preferably 70% by volume or less, more preferably 65% by volume or less, and still more preferably 60% by volume or less. ] Any one dentifrice.
[15] The volume ratio ((a2 + a3 + a4) / a5) of the total content of granules (a2), granules (a3) and granules (a4) to the contents of granules (a5) is preferably 2.5 or more More preferably, it is 3 or more, More preferably, it is 3.5 or more, Preferably it is 7 or less, More preferably, it is 6 or less, More preferably, it is 5 or less The said [1]-[14 ] Any one dentifrice.

[16] The disintegration strength of the granules (A) is preferably 0.2 g / piece or more, more preferably 0.5 g / piece or more, preferably 10 g / piece or less, more preferably 8 g / piece. The dentifrice according to any one of [1] to [15] above.
[17] The content of the granule (A) is 2% by mass or more, preferably 3% by mass or more, more preferably 5% by mass or more, and 40% by mass or less, preferably 25%. The dentifrice according to any one of the above [1] to [16], which is not more than mass%, more preferably not more than 20 mass%.
[18] The content of water in the dentifrice of the present invention is preferably more than 0% by mass, more preferably 10% by mass or more, preferably 60% by mass or less, more preferably 50% by mass. The dentifrice of any one of [1] to [17] above.
[19] The dentifrice of any one of [1] to [18] above, wherein the granule (A) is obtained by mixing two or more granules having different average particle diameters.
[20] A step of mixing granules having an average particle size of 100 to 500 μm and a disintegration strength of 0.1 g / piece or more and 15 g / piece or less into a base containing a wetting agent and a binder, and at least a part of The method for producing a dentifrice according to any one of the above [1] to [19], comprising a step of stirring at a rotational speed at which the granules are crushed.

  Hereinafter, the present invention will be specifically described based on examples. In addition, unless otherwise indicated in a table | surface, content of each component shows the mass%.

[Preparation Example 1: Preparation of Granule A-1]
Silicic anhydride (sorbosyl AC77, PQ Corporation, average particle size 9.5 μm, RDA value 125, oil absorption 129 mL / 100 g) 67 parts by mass, colloidal silica (Snowtex SK, Nissan Chemical) 28 parts by mass, cellulose (KC floc W -400G, Nippon Paper Chemicals Co., Ltd.) 5 parts by mass and purified water are mixed to form a water slurry having a solid content of 50% by mass, and this water slurry is blown at a temperature of 200 ° C. and exhausted at a temperature of 80 to 90 ° C. Spray granulated. The viscosity of the water slurry at 25 ° C. before spraying was 385 mPa · s, and the granules after granulation had a disintegration strength of 5 g / piece with a particle diameter of 180 to 200 μm.
Granules after granulation were classified by JIS standard sieve (JIS Z8801-1982), and the classified granules were mixed with blending amounts for each particle size shown in Table 1 to obtain granules A-1.
The above oil absorption amount is specified by the amount of oil to be absorbed in boiled sesame based on JIS K5101-13-2 (established in 2004). The RDA value was measured by ISO 11609 polishing test method appendix A.
A graph of the particle size distribution of Granule A-1 is shown in FIG.

[Preparation Example 2: Preparation of granules A-2 to A-4, A-6, A-7]
Granules granulated in Preparation Example 1 are classified by JIS standard sieve (JIS Z8801-1982), and the classified granules are mixed in the blending amounts for each particle size shown in Table 1 to give granules A-2 to A-7. Got. A graph of the particle size distribution of granules A-4 and granules A6-7 is shown in FIG.

[Preparation Example 3: Preparation of Granule A-5]
Granule A-5 was prepared by mixing granules having an average particle diameter of 200 μm and granules having an average particle diameter of 150 μm obtained by changing the spray granulation conditions of Preparation Example 1 at a mass ratio of 5: 3. It is the granule in the dentifrice manufactured according to prescription of Example 1 shown in Table 2, and stirring with mixing with another component. The particle size distribution of granule A-5 shown in Table 1 was measured by extracting granules of the produced dentifrice (Example 1), and includes granules A-5 and granules having a particle size of less than 45 μm. Specifically, the particle size distribution of granules A-5 in the dentifrice was measured according to the following method.
A graph of the particle size distribution of Granule A-5 is shown in FIG.
In addition, granule A-5 used for the dentifrice (Example 6) shown in Table 3 classifies the granule after the granulation by the adjustment example 1 with a JIS standard sieve (JIS Z8801-1982), and the granule shown in Table 1 According to the blending amount of each particle size of A-5, each classified granule is mixed and obtained.

[Method for measuring particle size distribution of granules in dentifrice]
(1) Extraction of granules in dentifrice: After the dentifrice is diluted 20 times by mass with purified water, the supernatant is removed by centrifugation, and the slurry containing the remaining granules and powder is dried. The granules and powder in the dentifrice were extracted. Centrifugation was performed using a centrifuge (himac CF702, manufactured by HITACHI) at 10,000 rpm for 10 minutes. The slurry was dried by storage at 110 ° C. for 1 day and night (about 12 hours).
(2) Measurement of particle size distribution: The particle size distribution of the obtained powders and granules was measured using a laser diffraction / scattering particle size distribution measuring device (Partica LA-950V2, manufactured by Horiba, Ltd.).
(3) Calculation of the content (volume%) of each granule: The content (volume%) of the granule contained in the dentifrice is based on the result of particle size distribution by laser diffraction, according to the calculation method shown below. The content of each granule (a1) to (a6) was obtained as a calculated value.

<< Calculation method of particle size distribution of granules (a1) to (a6) by laser diffraction >>
The particle size distribution of the granules (a1) to (a6) is based on the size of the sieve of JIS standard sieve (JIS Z8801-1982). Therefore, the amount (volume%) of granules (a1) to (a6) in the range of each particle size is calculated from the particle size distribution measured by laser diffraction. Specifically, the amount of granules (a1) to (a6) is calculated by multiplying the content of each particle size range by the ratio of the particle size range for each particle size range measured by laser diffraction. For example, when the volume of granules having a particle diameter of 45 μm or more and less than 51 μm is 2.5% by volume and the granule having a particle diameter of 51 μm or more and less than 68 μm is 1.8% by volume by laser diffraction, the content of the granules (a1) is 2. 8% by volume + 1.8% by volume × (65−51) / (68−51), and the calculation result is 4.3% by volume.

[Evaluation Test 1: Evaluation of dirt removal performance in dentifrice]
For brushing using the toothpaste of Example 1 and Comparative Examples 1 and 2 of the formulations shown in Table 2 and brushing using only a toothbrush that does not use a dentifrice (Reference Example 1), dirt removal performance using the following extracted teeth The soil removal performance in an actual use environment was evaluated.

(Evaluation Test 1-1: Evaluation by Extracted Teeth)
One anterior tooth is divided into left and right teeth, and the left tooth as viewed from the lip side of the tooth with 1g of the dentifrice of Example 1, and the right tooth with 1g of the dentifrice of Comparative Example 1 (check standard, Kao) And made by a dental hygienist for 3 minutes. The teeth before and after toothbrushing of Example 1 are shown in FIG. 2, and the teeth before and after toothbrushing of Comparative Example 1 are shown in FIG. As shown in FIGS. 2 to 3, it can be seen that, after brushing the teeth, the stains that were yellowish on the teeth were almost removed in Example 1, but the stains were hardly removed in Comparative Example 1. This remaining dirt is considered to be dirt attached to a recess of 100 μm or less which cannot be reached by the bristle of the toothbrush formed on the tooth surface.

(Evaluation Test 1-2: Evaluation under Use Environment)
Using the dentifrice of Example 1 and Comparative Example 2 in which the granules of Example 1 are replaced with abrasive silica, each of the 16 test subject teeth who answered that the teeth had colored stains according to a preliminary questionnaire was brushed for 4 weeks. The condition of the teeth after brushing was evaluated. Specifically, before and after the evaluation test, take a picture of the tooth after brushing, extract the colored part by image analysis, determine the area of the colored part by image analysis software "WinROOF" (Mitani Corporation), Evaluation was made by comparing the areas of the colored sites in the teeth before the start of evaluation and the teeth after 4 weeks. More specifically, the difference in the area of the colored portion of the tooth before the start of evaluation and the tooth after 4 weeks was evaluated as a soil removal area. The results are shown in FIG. In addition, the dirt removal area shown in FIG. 4 is a value of (area of the colored part of the tooth before the start of evaluation) − (area of the colored part of the tooth after 4 weeks), and is the right side of each subject's upper jaw and lower jaw. This is a value obtained by averaging the results of each test subject on the surface of a total of eight lips, including the side incisors, right middle incisors, left middle incisors, and left side incisors.
Further, FIG. 5 shows a photograph of the condition of the subject before the start of evaluation by the subject according to Example 1 and the state of the colored stain after 4 weeks. FIG. 5 (a) is a photograph showing a part of the evaluated teeth, and FIG. 5 (b) is an enlarged photograph of the space between the teeth. Similarly, the photograph by the comparative example 2 is shown in FIG. 6A is a photograph of the evaluated tooth, and FIG. 6B is an enlarged photograph of the space between the teeth.

  As shown in FIG. 4, the area free from contamination by the dentifrice of Example 1 was twice that of the dentifrice of Comparative Example 2. Further, as shown in FIG. 5, in Example 1, yellowing stains adhering to the distal lip groove or mesial lip groove of the teeth and yellowing stains between the teeth were removed after 4 weeks. I understand that. On the other hand, as shown in FIG. 6, in Comparative Example 2, it was recognized that these yellowing stains remained even after 4 weeks, and the stains attached to the fine recesses on the tooth surface were removed as compared with Example 1. It is estimated that it was difficult.

  In order to show more detailed irregularities such as the cleft lip groove and the near lip groove where tooth stains are likely to remain, the irregularities on the tooth surface are shown in FIG. FIG. 7 shows the actual tooth irregularities measured by a microscope (One Shot 3D, manufactured by Keyence Corporation). As shown in FIG. 7, not only the above-mentioned centrifugal lip groove and mesial lip groove but also fine irregularities of 30 μm to 120 μm are formed on the surface of the teeth.

[Evaluation Test 2: Measurement of dirt removal rate with dentifrice]
About the dentifrice of Example 1 of the prescription shown in Table 2, and Comparative Examples 1-2, and the reference example 1 only by the toothbrush which does not use a dentifrice, the following uneven | corrugated model and a dirt model are used, and the brushing test according to the following method The soil removal rate was calculated. The results are shown in Table 2.

(Uneven model)
A concavo-convex model was prepared in which a plurality of linear grooves of the following various sizes with a corner of 90 ° C. were provided in parallel on stainless steel having a length of 15 mm × width of 15 mm × thickness of 3 mm.
Concave and convex model 1: grooves having a width of 1000 μm and a depth of 150 μm were provided at intervals of 670 μm.
Concavity and convexity model 2: Grooves having a width of 100 μm and a depth of 100 μm were provided at intervals of 620 μm.
Concave and convex model 3: grooves having a width of 50 μm and a depth of 50 μm were provided at intervals of 620 μm.

(Dirty model)
Using an eyeliner (Sana Super Quick Eyeliner EX01, manufactured by Tokiwa Yakuhin Kogyo Co., Ltd.) as a dirt model, it was rubbed and filled into the entire groove of the uneven model, and adhered to the dirt model and surface protruding on the uneven model surface. The dirt model was removed by sliding the horizontal surface of the spatula along the surface of the uneven model.

(Brushing test)
The above uneven model is inserted into a 15 mm × 15 mm × 3 mm square recess provided in the center of an aluminum plate (30 mm × 80 mm × 5 mm), each dentifrice 2 g, toothbrush (Check Standard, manufactured by Kao), brushing condition: load 200 g, speed 120 rpm, amplitude 30 mm, number of brushes 30 st (reciprocation 30 times), brushing direction: a brushing test was performed in a direction parallel to the groove direction of the concavo-convex model. It should be noted that a scraping recess for facilitating taking out the uneven model is provided outside the square at the corner of the recess of the square of the aluminum plate.

(Calculation method of dirt removal rate)
After brushing, the uneven model was taken out from the aluminum plate, washed with water, and then the dentifrice adhering to the surface of the uneven model was removed by sliding the surface of the uneven model against paper (PPC paper A4 size, KOKUYO).
The unevenness model before brushing and the unevenness model from which the dentifrice was removed were photographed with a digital camera, and the area of the unevenness model before brushing colored by the eyeliner was defined as a colored region area (mm ² ). The area evaluation region area of the region brushed by the toothbrush in the colored area (mm ²⁾ and then, the bottom surface of the recess is exposed fallen eyeliner in such evaluation region (becomes white) area of a portion (mm ²⁾ Was defined as a soil removal area. Next, the soil removal area with respect to the entire evaluation area was calculated as the soil removal rate (%) by the following formula (1). The area of the colored region is the area of the region where coloring due to the pseudo-fouling substance was detected when photographed with a digital camera, and the region where the toothbrush was wiped out in that region was used as the evaluation region.
Dirt removal rate (%) = (dirt removal area / total evaluation area) × 100 (1)
Note that the eyeliner rubbed into the recess of the test plate is a flat surface that is wiped off with only a toothbrush, and the eyeliner falls and exposes the surface of the test plate even if a predetermined load is applied. In the shooting with a digital camera, a flash was used and a polarizing filter was used to remove the surface reflected light.

[Evaluation test 3: Evaluation of feeling of cleaning]
About Example 1 of the prescription shown in Table 2, and the toothpaste of Comparative Examples 1-2, and the reference example 1 only by the toothbrush which does not use a dentifrice, when using a dentifrice, 1g is used, and a toothbrush (Check Standard, Kao product) After brushing the teeth as usual for 2 minutes, the feel of touching the buccal surface of the maxillary incisor with the tongue was evaluated according to the following criteria. In addition, the following evaluation criteria set it as the relative evaluation which made the reference example 1 "1". In addition, the test subject is a person who can recognize that the dirt of the teeth has accumulated in the recess two days after stopping the brushing, and Table 2 shows the evaluation results by the consultation of three persons.
4: It is very smooth to feel no dirt in the tooth recess.
3: Slightly felt that the tooth recess is dirty, but has a smooth feel.
2: Feels that the recess of the tooth is dirty due to the uneven feel.
1: The uneven feeling is strong, and it is felt strongly that there is dirt in the tooth recess.

  As shown in Table 2, Example 1 shows a significantly higher dirt removing effect than Comparative Examples 1 and 2 from a large concave part to a small concave part, and in particular, a dirt removal rate compared with Comparative Example 1 in a concave part having a width of 100 μm. It can be seen that there is a large difference, and the feel of the tooth surface with the tongue is very smooth and provides an excellent cleaning feeling.

[Evaluation Test 4: Measurement of dirt removal rate by gel dentifrice]
About the gel dentifrice which mixed granule A-1 to A-7 shown in Table 3, it carried out similarly to the evaluation test 2, and measured dirt removal rate.
The results are shown in Table 3.

  As shown in Table 3, granules A-1 to A-5 show a high dirt removal rate for both dirt of grooves having a width of 100 μm and a width of 50 μm, but granules A-6 have a width of 50 μm. The dirt removal performance of the grooves was low, and Granule A-7 obtained a result of low dirt removal performance of the grooves having a width of 100 μm. As described above, the dentifrice of the present invention containing granules (a1) to (a6) in a balance satisfying the above volume ratio and containing granules (A) having a specific disintegration strength is used for toothbrushes and normal polishing. A high dirt removal effect can be obtained from dirt attached to a recess having a width of 50 μm to dirt attached to a recess having a width of 100 μm, which is difficult to remove with an agent.

Claims (7)

The particle size is 45 μm or more, and the following granules (a1) to (a6):
(A1) Granules having a particle size of 45 μm or more and less than 63 μm (a2) Granules having a particle size of 63 μm or more and less than 90 μm 10% to 18% by volume (a3) Granules having a particle size of 90 μm or more and less than 125 μm (a4) Particle size 125 μm Granules having a particle size of 150 μm or more and less than 150 μm (a5) Granules having a particle size of 150 μm or more and less than 180 μm (a6) Granules (A) consisting of 20 to 52 vol%
The total content of granules (a2), granules (a3) and granules (a4) is 40% by volume or more, and the total contents of granules (a2), granules (a3) and granules (a4) The volume ratio ((a2 + a3 + a4) / a6) to the content of a6) is 1 or more and 2 or less, and the volume ratio (a2 / a3) of the content of granules (a2) and granules (a3) is 0.5 or more and 2 The volume ratio (a4 / a3) of the content of the granules (a4) and granules (a3) is 0.5 or more and 2 or less, and the disintegration strength of the granules is 0.1 g / piece or more and 15 g / piece or less. A dentifrice containing 2% by mass or more and 40% by mass or less of the granule (A).   The dentifrice of Claim 1 whose content of a granule (a3) is 8 volume% or more and 25 volume% or less in a granule (A).   The dentifrice of Claim 1 or 2 whose volume ratio (a5 / a3) of content of a granule (a5) and a granule (a3) is 0.4 or more and 1.5 or less. The dentifrice according to any one of claims 1 to 3 , wherein the content of the granule (a1) is 5 vol% or more and 18 vol% or less. The volume ratio ((a2 + a3 + a4) / a5) of the total content of the granule (a2), granule (a3) and granule (a4) to the content of the granule (a5) is from 2.5 to 7 The dentifrice of any one of claim | item 1-4. The volume ratio ((a2 + a3 + a4 + a5) / a6) of the total content of granules (a2), granules (a3), granules (a4) and granules (a5) to the contents of granules (a6) is 0.8 or more It is 2.5 or less, The dentifrice of any one of Claims 1-5 The dentifrice according to any one of claims 1 to 6, wherein the content of the granule (a4) is 10 vol% or more and 18 vol% or less in the granule (A).