JP6342155B2 - Skin sheet - Google Patents

Description

  The present invention relates to an external preparation composition and a skin sheet.

Conventionally, the purpose of the skin sheet is to refresh and remove dirt.
In recent years, due to the need for higher functional skin sheets, it has been desired to improve the function of the skin by incorporating an external skin drug into the skin sheet for the purpose of treating the skin.

  External preparations for skin include antipruritics, antihistamines, skin repair agents, anti-inflammatory agents, etc., and many of these are when used as drug solutions, temperature stability, especially storage stability at low temperatures (low temperature stability, freezing stability) There is a problem that coloring and precipitation occur during storage (for example, see Patent Document 1). Further, among the above-mentioned external preparations for skin, there is a problem that many of them are difficult to be contained in a sheet because they are poorly water-soluble and do not contain a solvent even when added to a conventional skin sheet. is there.

Diphenhydramine hydrochloride is a drug having an antipruritic action.
Allantoin is a poorly water-soluble drug having a skin repair effect.
Glycyrrhizic acid is a drug having an anti-inflammatory effect. Glycyrrhizic acid is sparingly water-soluble, but it is water-soluble in the salt state such as potassium salt.
A chemical solution containing diphenhydramine hydrochloride, allantoin, and glycyrrhizinate is inferior in storage stability at low temperatures (low temperature stability, freeze recovery property).

  In recent years, it has been desired to provide a chemical solution (external preparation composition) containing diphenhydramine hydrochloride, allantoin and glycyrrhizinate that gives a refreshing sensation when impregnated in absorbent cotton or non-woven fabric and used on the skin.

JP 2004-143128 A

  An object of the present invention is to solve various problems in the prior art and achieve the following objects. That is, the present invention provides a sheet of the external preparation composition that gives a refreshing feeling when applied to the skin, and the external preparation composition that gives a comfortable feeling of use (feeling that sweat and dirt have been wiped off, and a refreshing feeling) when wiping. An object of the present invention is to provide a skin sheet impregnated in a substrate.

  As a result of intensive studies to achieve the above object, the present inventors have found that an external preparation composition containing (A) diphenhydramine hydrochloride, (B) allantoin, (C) glutyrrhizinate, and (D) ethanol. The product gives a refreshing sensation when applied to the skin, and the skin sheet impregnated with the above-mentioned external preparation composition in a sheet-like base material feels comfortable when wiping off (feeling that sweat and dirt have been wiped off, and cooling It was found that it gives a feeling.

  This invention is based on the said knowledge by the present inventors, and as means for solving the said subject, it is as follows. That is, the present invention is an external preparation composition comprising (A) diphenhydramine hydrochloride, (B) allantoin, (C) glutyl ritinate, and (D) ethanol.

  ADVANTAGE OF THE INVENTION According to this invention, the various problems in the past can be solved, and the external preparation composition that gives a refreshing feeling when applied to the skin, and a comfortable feeling when wiping off (feeling that sweat and dirt have been wiped off, and a refreshing feeling) A skin sheet in which a sheet-like base material is impregnated with the external preparation composition providing the above can be provided.

(External preparation composition)
The composition for external use of the present invention comprises (A) diphenhydramine hydrochloride, (B) allantoin, (C) glutyrrhizinate, and (D) ethanol, preferably (E) polyhydric alcohol, (F ) It contains a surfactant, and further contains other components as necessary.

<(A) Diphenhydramine hydrochloride>
The diphenhydramine hydrochloride is an active ingredient having an antipruritic effect in the external preparation composition.
The diphenhydramine hydrochloride is a salt of a compound represented by the following structural formula (1) and is an antagonist to one of histamine receptors, H ₁ receptor.

  There is no restriction | limiting in particular as content with respect to the said external preparation composition of the said diphenhydramine hydrochloride, Although it can select suitably according to the objective, 0.1 to 5.0 mass% is preferable, and 0.0. 3 mass% or more and 5.0 mass% or less are more preferable, and 0.5 mass% or more and 2.0 mass% or less are especially preferable. If the content is less than 0.1% by mass, the antipruritic effect may not be sufficient, and if it exceeds 5.0% by mass, the storage stability may be deteriorated.

<(B) Allantoin>
The allantoin is an active ingredient having a skin repair effect in the external preparation composition.
The allantoin is a poorly water-soluble compound represented by the following structural formula (2).

  There is no restriction | limiting in particular as content with respect to the said external preparation composition of the said allantoin, Although it can select suitably according to the objective, 0.01 to 5.0 mass% is preferable, 0.1 mass % To 3.0% by mass is more preferable, and 0.1% to 1.0% by mass is particularly preferable. When the content is less than 0.01% by mass, the skin repair effect may not be sufficient, and when it exceeds 5.0% by mass, the storage stability may be deteriorated.

<(C) Glycyrrhizinate>
The glycyrrhizinate is an active ingredient having an anti-inflammatory effect in the external preparation composition.
The glycyrrhizinate is not particularly limited as long as it is a salt of glycyrrhizic acid, and can be appropriately selected according to the purpose. Examples thereof include dipotassium glycyrrhizinate.
Glycyrrhizic acid is a compound represented by the following structural formula (3) and is poorly water-soluble, but it becomes water-soluble when converted into a salt.

  There is no restriction | limiting in particular as content with respect to the said external preparation composition of the said glycyrrhizinate, Although it can select suitably according to the objective, 0.01 to 5.0 mass% is preferable, and 0. 1 mass% or more and 3.0 mass% or less are more preferable, and 0.1 mass% or more and 1.0 mass% or less are especially preferable. When the content is less than 0.01% by mass, the anti-inflammatory effect may not be sufficient, and when it exceeds 5.0% by mass, the storage stability may be deteriorated.

<(D) Ethanol>
In the external preparation composition, the ethanol assists the dissolution of the allantoin and gives a refreshing feeling when applied to the skin. The ethanol is a component that gives a refreshing feeling and a feeling that the sweat and dirt are wiped off when the external preparation composition is impregnated in the skin sheet, and improves the dirt removal effect.

  There is no restriction | limiting in particular as content with respect to the said external preparation composition of the said ethanol, Although it can select suitably according to the objective, 0.1 to 50 mass% is preferable, and 1 to 25 mass is preferable. % Is more preferable, and 5% by mass or more and 25% by mass or less is particularly preferable. When the content is less than 0.1% by mass, a refreshing feeling may not be sufficient, and when it exceeds 50% by mass, irritation during use may be a concern. When the content is 5% by mass or more and 25% by mass or less, it is advantageous in terms of the speed and strength of the antipruritic effect.

<(E) Polyhydric alcohol>
In the external preparation composition, the polyhydric alcohol improves low temperature stability, assists the dissolution of the allantoin, and provides a moisturizing feeling. The polyhydric alcohol is a component that gives a feeling that sweat and dirt are wiped off when the external preparation composition is impregnated in a skin sheet, and improves the dirt removal effect.
There is no restriction | limiting in particular as said polyhydric alcohol, According to the objective, it can select suitably, For example, Divalent alcohol, such as 1, 3- butylene glycol and propylene glycol; Trivalent alcohol, such as glycerol; D -Hexavalent alcohols such as sorbitol; Alcohol alkyl ethers such as polyethylene glycol; Sugar alcohols such as maltotetraose; Polysaccharide alcohols such as heparin-like substances. These may be used alone or in combination of two or more. Among these, 1,3-butylene glycol, propylene glycol, and glycerin are preferable, and 1,3-butylene glycol is more preferable.

  There is no restriction | limiting in particular as content with respect to the said external preparation composition of the said polyhydric alcohol, Although it can select suitably according to the objective, 0.1 mass% or more and 50 mass% or less are preferable, and 1 mass% or more 25 mass% or less is more preferable, and 5 mass% or more and 25 mass% or less are especially preferable. When the content is less than 0.1% by mass, the moisturizing feeling may not be sufficiently imparted, and when it exceeds 50% by mass, stickiness during use may be a concern. When the content is 5% by mass or more and 25% by mass or less, it is advantageous in terms of the speed and strength of the antipruritic effect.

<(F) Surfactant>
The surfactant improves low temperature stability in the external preparation composition.
There is no restriction | limiting in particular as said surfactant, According to the objective, it can select suitably, For example, a nonionic surfactant, a cationic surfactant, an anionic surfactant etc. are mentioned. Among these, nonionic surfactants are preferable. These may be used alone or in combination of two or more.

-Nonionic surfactant-
There is no restriction | limiting in particular as said nonionic surfactant, According to the objective, it can select suitably, For example, propylene glycol fatty acid ester, glycerol fatty acid ester, polyglycerol fatty acid ester, polyoxyethylene (POE) glycerol fatty acid Examples include esters, sorbitan fatty acid esters, POE sorbitan fatty acid esters, POE sorbite fatty acid esters, POE hydrogenated castor oil, POE sterols, POE alkyl ethers, POEPOP alkyl ethers, POE fatty acid esters, and the like. These may be used alone or in combination of two or more.

  There is no restriction | limiting in particular as said nonionic surfactant, What was synthesize | combined suitably may be used and a commercial item may be used. Examples of the commercially available products include NIKKOL (registered trademark) HCO-60 (manufactured by Nikko Chemicals Corporation), NIKKOL (registered trademark) HCO-50 (manufactured by Nikko Chemicals Corporation), and NIKKOL (registered trademark) BL-21 (Nikko). Chemicals Co., Ltd.), NIKKOL (registered trademark) BL-25 (Nikko Chemicals Co., Ltd.), polysorbate 80 HX2 (Nikko Co., Ltd.), and the like. These may be used alone or in combination of two or more.

-Cationic surfactant-
The cationic surfactant is not particularly limited and may be appropriately selected depending on the intended purpose. For example, alkyltrimethylammonium salt, dialkyldimethylammonium salt, alkylammonium salt, benzalkonium salt, benzethonium salt, pyridinium Salt, imidazolinium salt and the like. The counter ion (anion) of these cationic surfactants is a halogen ion or the like. These may be used alone or in combination of two or more.

-Anionic surfactant-
The anionic surfactant is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include an alkyl sulfate, an alkyl polyoxyethylene sulfate, an alkyl benzene sulfonate, an α-olefin sulfonate, Fatty acid salt, α-sulfo fatty acid salt, ether carboxylate, alkyl phosphate salt, alkyl phosphate polyoxyethylene salt, dialkyl sulfosuccinate ester salt, alkyl alkyl sulfosuccinate, alkenyl succinate, N-acyl amino acid salt, N -Acylmethyl taurine salt and the like. Note that counter ions (cations) of these anionic surfactants are alkali metal ions, alkaline earth metal ions, alkanolamine ions, ammonium ions, and the like. These may be used alone or in combination of two or more.

  There is no restriction | limiting in particular as content with respect to the said external preparation composition of the said surfactant, Although it can select suitably according to the objective, 0.05 mass% or more and 5.0 mass% or less are preferable, and 0.0. 1 mass% or more and 3.0 mass% or less are more preferable, and 0.2 mass% or more and 2.0 mass% or less are especially preferable. If the content is less than 0.05% by mass, further low temperature stability may not be sufficiently imparted, and if it exceeds 5.0% by mass, the feel during use may be deteriorated.

<Other ingredients>
In the external preparation composition of the present invention, other components added to the normal external preparation composition can be blended as the above-mentioned other components as long as the effects of the present invention are not impaired.

  The other components are not particularly limited and may be appropriately selected depending on the purpose. For example, other agents, silicone oil, ester oil, humectant, thickener, pH adjuster, chelating agent, preservative Agents, powder components, liquid fats and oils, solid fats and oils, waxes, hydrocarbon oils, higher fatty acids, higher alcohols, ultraviolet absorbers, amino acids, organic amines, polymer emulsions, fragrances and the like. These may be used alone or in combination of two or more.

-Other drugs-
The other drug is not particularly limited as long as it can be formulated as an external preparation composition, and can be appropriately selected according to the purpose. For example, chlorpheniramine maleate, crotamiton, chlorpheny Lamin, indomethacin, ufenamate, prednisolone valerate acetate, glycyrrhetinic acid, tocopherol acetate, isopropylmethylphenol and the like can be mentioned. These may be used alone or in combination of two or more.

-Silicone oil-
The silicone oil is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include linear polysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane, diphenylpolysiloxane; octamethylcyclotetrasiloxane, deca Cyclic polysiloxanes such as methylcyclopentasiloxane and dodecamethylcyclohexasiloxane; various modified polysiloxanes such as amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, and fluorine-modified polysiloxane; forming a three-dimensional network structure Examples thereof include silicone resin and silicone rubber. These may be used alone or in combination of two or more.

-Ester oil-
The ester oil is not particularly limited and may be appropriately selected depending on the intended purpose. For example, isopropyl myristate, cetyl octoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristine Myristyl acid, decyl oleate, hexyl decyl dimethyloctanoate, cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, cholesteryl 1,2-hydroxystearate, ethylene glycol di-2-ethylhexanoate, di Pentaerythritol fatty acid ester, monoisostearic acid-alkyl glycol, neocaptyl glycol dicaprate, diisostearyl malate, glycerin di-2-heptylundecanoate, 2-ethylhexanoic acid trimethylolpropane, triisostearic acid trimethylolpropane, tetra-2-ethylhexanoic acid pentaerythritol, tri-2-ethylhexanoic acid glycerin, trioctanoic acid glycerin, triisopalmitic acid glycerin, triisostearic acid tri Methylolpropane, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, glycerin trimyristate, glyceride tri-2-heptylundecanoate, castor oil fatty acid methyl ester, oleyl oleate, acetoglyceride, 2-heptylunpalmitate Decyl, diisobutyl adipate, N-lauroyl-L-glutamic acid-2-octyldodecyl ester, di-2-heptylundecyl adipate, ethyl laurate Di-2-ethylhexyl sebacate, myristic acid 2-hexyl decyl palmitate, 2-hexyldecyl, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate, and the like triethyl citrate. These may be used alone or in combination of two or more.

-Humectant-
The moisturizing agent is not particularly limited and may be appropriately selected depending on the intended purpose. For example, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronic acid, atelocollagen, cholesteryl-1,2-hydroxystearate, 2- Methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer solution, sodium lactate, bile salt, dl-pyrrolidone carboxylate, short-chain soluble collagen, diglycerin (EO) PO adduct, Izayoi rose extract, yarrow extract, Merrilot An extract etc. are mentioned. These may be used alone or in combination of two or more.

-Thickener-
The thickener is not particularly limited and may be appropriately selected depending on the intended purpose.For example, carboxyvinyl polymer, acrylic acid / alkyl methacrylate copolymer, gum arabic, carrageenan, caraya gum, tragacanth gum, carob gum, Quince seed (malmello), casein, dextrin, gelatin, sodium pectate, sodium alginate, methyl cellulose, ethyl cellulose, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, polyvinyl alcohol (PVA), polyvinyl methyl ether (PVM), polyvinyl pyrrolidone (PVP) ), Polyacrylic acid and its sodium salt, dimethylacrylamide / acryloyldimethyltaurate cross-linked polymer, hydroacrylate Cyethyl / acryloyl dimethyl taurate salt cross-linked polymer, locust bean gum, guar gum, tamarint gum, dialkyldimethylammonium sulfate cellulose, xanthan gum, magnesium aluminum silicate, bentonite, hectorite, AlMg silicate (Begum), laponite, silicic anhydride, etc. Can be mentioned. These may be used alone or in combination of two or more.

-PH adjuster-
The pH adjuster is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include lactic acid-sodium lactate, citric acid-sodium citrate, succinic acid-sodium succinate, and phosphoric acid-sodium phosphate. , Malic acid-sodium malate, borax, boric acid and the like. These may be used alone or in combination of two or more.

-Chelating agent-
The chelating agent is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include 1-hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-diphosphonic acid tetrasodium salt, and edetic acid diester. Sodium, edetate trisodium, edetate tetrasodium, sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, malic acid, ascorbic acid, succinic acid, edetic acid, ethylenediamine hydroxyethyl triacetic acid Examples include trisodium. These may be used alone or in combination of two or more.

-Preservative-
There is no restriction | limiting in particular as said preservative, According to the objective, it can select suitably, For example, methylparaben, ethylparaben, butylparaben, phenoxyethanol, sodium benzoate etc. are mentioned. These may be used alone or in combination of two or more.

-Powder component-
The powder component is not particularly limited and may be appropriately selected depending on the intended purpose. For example, inorganic powders (for example, talc, kaolin, mica, sericite, muscovite, phlogopite, synthetic mica, safmica, Biotite, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, silica, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate Fluorine apatite, hydroxyapatite, ceramic powder, metal soap (for example, zinc myristate, calcium palmitate, aluminum stearate), boron nitride, etc.); organic powder (for example, polyamide resin powder, polyethylene powder, polymethacrylate) Methyl powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, benzoguanamine resin powder, polytetrafluoroethylene powder, cellulose powder, etc.); inorganic white pigment (eg, titanium dioxide, zinc oxide, etc.); inorganic red Pigments (for example, iron oxide, iron titanate, etc.); inorganic brown pigments (for example, γ-iron oxide); inorganic yellow pigments (for example, yellow iron oxide, loess); inorganic black pigments (for example, Black iron oxide, low-order titanium oxide, etc.); inorganic purple pigments (eg, mango violet, cobalt violet, etc.); inorganic green pigments (eg, chromium oxide, chromium hydroxide, cobalt titanate, etc.); inorganic blue pigments (E.g. ultramarine, bitumen, etc.); pearl pigments (e.g., titanium oxide coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated) Dotalc, colored titanium oxide coated mica, bismuth oxychloride, fish scale foil, etc.); metal powder pigments (eg, aluminum powder, copper powder, etc.); organic pigments such as zirconium, barium or aluminum lake (eg, red 201, red 202) No., Red No. 204, Red No. 205, Red No. 220, Red No. 226, Red No. 228, Red No. 405, Orange No. 203, Orange No. 204, Yellow No. 205, Yellow No. 401, Blue No. 404, etc. Red No. 3, Red No. 104, Red No. 106, Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Green No. 3 No., Blue No. 1, etc.); natural pigments (for example, chlorophyll, β-carotene, etc.) and the like. These may be used alone or in combination of two or more.

-Liquid oil
The liquid fat is not particularly limited and can be appropriately selected according to the purpose.For example, avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, Sesame oil, persic oil, wheat germ oil, sasanqua oil, castor oil, flaxseed oil, safflower oil, cottonseed oil, eno oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, cinnagiri oil, Japanese kiri oil, Examples include jojoba oil, germ oil, and triglycerin. These may be used alone or in combination of two or more.

-Solid fats and oils-
The solid fat is not particularly limited and may be appropriately selected depending on the purpose. For example, cacao butter, palm oil, horse fat, hydrogenated palm oil, palm oil, beef tallow, sheep fat, hardened beef tallow, palm kernel Examples include oil, pork fat, beef bone fat, owl kernel oil, hydrogenated oil, beef leg oil, molasses, hydrogenated castor oil. These may be used alone or in combination of two or more.

-Wax-
The waxes are not particularly limited and may be appropriately selected depending on the intended purpose. For example, beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, ibota wax, whale wax, montan wax, nukarou, lanolin, kapok wax, lanolin acetate , Liquid lanolin, sugarcane wax, lanolin fatty acid isopropyl, hexyl laurate, reduced lanolin, jojoba wax, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, POE hydrogenated lanolin alcohol Examples include ether. These may be used alone or in combination of two or more.

-Hydrocarbon oil-
The hydrocarbon oil is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include liquid paraffin, ozokerite, squalane, pristane, paraffin, ceresin, squalene, petrolatum, and microcrystalline wax. These may be used alone or in combination of two or more.

-Higher fatty acids-
The higher fatty acid is not particularly limited and may be appropriately selected depending on the intended purpose. For example, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, undecylenic acid, tallic acid, isostearic acid Linoleic acid, linolenic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and the like. These may be used alone or in combination of two or more.

-Higher alcohol-
The higher alcohol is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include linear alcohols (for example, lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol). Etc.); branched chain alcohols (for example, monostearyl glycerin ether (batyl alcohol), 2-decyltetradecinol, lanolin alcohol, cholesterol, phytosterol, hexyl decanol, isostearyl alcohol, octyldodecanol, etc.) . These may be used alone or in combination of two or more.

-UV absorber-
The ultraviolet absorber is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include benzoic acid-based ultraviolet absorbers (for example, paraaminobenzoic acid (hereinafter abbreviated as PABA), PABA monoglycerin ester, N, N-dipropoxy PABA ethyl ester, N, N-diethoxy PABA ethyl ester, N, N-dimethyl PABA ethyl ester, N, N-dimethyl PABA butyl ester, N, N-dimethyl PABA ethyl ester, etc.); anthranilic acid type UV absorber (for example, homomenthyl-N-acetylanthranylate); salicylic acid UV absorber (for example, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-iso Ropanolphenyl salicylate, etc.); cinnamic acid-based UV absorbers (for example, octylmethoxycinnamate, ethyl-4-isopropylcinnamate, methyl-2,5-diisopropylcinnamate, ethyl-2,4-diisopropylcinnamate, Methyl-2,4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, octyl-P-methoxycinnamate (2-ethylhexyl-p-methoxycinnamate) Mate), 2-ethoxyethyl-p-methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl-α-cyano-β-phenylcinnamate, glycerylmo No-2-ethylhexanoyl-diparamethoxycinnamate, etc.); 3- (4′-methylbenzylidene) -d, l-camphor, 3-benzylidene-d, l-camphor, 2-phenyl-5-methylbenzo 2,2'-hydroxy-5-methylphenylbenzotriazole, 2- (2'-hydroxy-5'-t-octylphenyl) benzotriazole, 2- (2'-hydroxy-5'-methylphenylbenzo) Triazole, dibenzalazine, dianisoylmethane, 4-methoxy-4′-t-butyldibenzoylmethane, 5- (3,3-dimethyl-2-norbornylidene) -3-pentan-2-one dimorpholinopyridazinone These may be used alone or in combination of two or more.

-Amino acid-
There is no restriction | limiting in particular as said amino acid, According to the objective, it can select suitably, For example, neutral amino acids (for example, threonine, cysteine, etc.); basic amino acids (for example, hydroxy lysine etc.); derivatives of amino acids, etc. Is mentioned. Examples of the amino acid derivatives include acyl sarcosine sodium (lauroyl sarcosine sodium), acyl glutamate, acyl β-alanine sodium, glutathione, and pyrrolidone carboxylic acid. These may be used alone or in combination of two or more.

-Organic amine-
The organic amine is not particularly limited and may be appropriately selected depending on the intended purpose. For example, monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1, Examples include 3-propanediol and 2-amino-2-methyl-1-propanol. These may be used alone or in combination of two or more.

-Polymer emulsion-
There is no restriction | limiting in particular as said polymer emulsion, According to the objective, it can select suitably, For example, an acrylic resin emulsion, an acrylic resin liquid, a polyacryl alkylester emulsion, a polyvinyl acetate resin emulsion etc. are mentioned. These may be used alone or in combination of two or more.

-Fragrance-
There is no restriction | limiting in particular as said fragrance | flavor, According to the objective, it can select suitably, For example, the fragrance | flavor component etc. which were described in Paragraph Nos. [0021]-[0035] of Unexamined-Japanese-Patent No. 2003-300811 etc. are mentioned. . These may be used alone or in combination of two or more.

<Mass ratio (D / E) and total content of (D) ethanol and (E) polyhydric alcohol>
When the external preparation composition of the present invention contains the polyhydric alcohol of the component (E), the mass ratio of the content of the ethanol of the component (E) and the content of the polyhydric alcohol of the component (E) ( D / E) is preferably 5/1 to 1/5, and more preferably 4/1 to 1/4.
Within the range of the mass ratio (D / E), it is advantageous in that it has an excellent effect of suppressing the itch that combines the speed of the antipruritic effect and the strength of the antipruritic effect.
The total content of the component (D) and the component (E) is preferably 5% by mass to 50% by mass, and more preferably 10% by mass to 40% by mass. If the total content is less than 5% by mass, the effect of suppressing itching may be weakened, and if it exceeds 50% by mass, the feeling of use may be reduced.

<PH>
There is no restriction | limiting in particular as pH of the said external preparation composition, Although it can select suitably according to the objective, 2.0 or more and 9.0 or less are preferable, 3.0 or more and 7.5 or less are more preferable, 4.0 to 6.0 is particularly preferable. When the pH is less than 2.0, glycyrrhizinate may be decomposed, and when it exceeds 9.0, allantoin may be decomposed.

<How to use>
There is no restriction | limiting in particular as the usage method of the said external preparation composition, According to the objective, it can select suitably, For example, the method of using as a liquid agent (after that it wipes off with a tissue etc.), the chemical | medical solution was impregnated to the nonwoven fabric The usage method with a sheet | seat (wet tissue), the method of using a chemical | medical solution for skin after soaking in a puff etc. are mentioned.

(Skin sheet)
The skin sheet of the present invention is obtained by impregnating a sheet-like base material with an external preparation composition.
The said external preparation composition is the external preparation composition of this invention mentioned above.

<Sheet substrate>
There is no restriction | limiting in particular as said sheet-like base material, According to the objective, it can select suitably. The material for the sheet-like substrate is not particularly limited as long as it is a material that can absorb the external preparation composition and can hold a sufficient amount between the fibers and the surface, depending on the purpose. For example, natural fibers such as cotton, pulp, hemp, and silk; recycled fibers such as polynosic, cupra, lyocell, acetate, and rayon; synthetic fibers such as nylon, acrylic, and polyamide can be used. These may be used singly or as a mixture of two or more as long as the water-absorbing property as a sheet base material is maintained. Low water-absorbing properties such as polyester, polypropylene, polyurethane, etc. You may mix and use a fiber. As the sheet-like substrate, paper and nonwoven fabric are preferable in terms of processability and cost, and a nonwoven fabric containing cotton and / or rayon is more preferable in terms of good touch and high dirt removal effect.

As a commercial item of the said sheet-like base material, for example, 100% cotton spunlace nonwoven fabric (basis weight: 40 g / m ² ) (manufactured by Nisshinbo Co., Ltd.), rayon / PE / PP core-sheath fiber (NBFH) = 80 / 20 (mass ratio) spunlace nonwoven fabric (basis weight: 60 g / m ² ) (manufactured by Daiwabo Co., Ltd.), PET / PP split fiber: rayon = 60: 40 (mass ratio) (basis weight: 75 g / m ² ) (Daiwabo) Etc.).

  There is no restriction | limiting in particular as said nonwoven fabric, Although it can select suitably according to the objective, It is preferable that 30 mass% or more of the said natural fiber and / or the said reproduction | regeneration fiber are contained, and more than 55 mass% is included. Preferably, 80 mass% or more is further included.

<Method for producing sheet for skin>
The method for producing the skin sheet is not particularly limited and may be appropriately selected according to the purpose. The skin sheet may be produced according to the 15th revised Japanese Pharmacopoeia General Rules for Lotions, for example, a membrane. Examples thereof include a method of impregnating a water-absorbing nonwoven fabric with the external preparation composition filtered with a filter (for example, Omnipore JHWP04700, manufactured by Merck Millipore).

<Impregnation>
The skin sheet of the present invention can be obtained by impregnating the external preparation composition into the sheet-like base material. The impregnation method is not particularly limited and may be appropriately selected depending on the purpose. For example, (1) a method of impregnating the sheet-like base material by dripping or spraying the external preparation composition, (2) A method of impregnating the sheet-like base material by immersing it in the external preparation composition is exemplified.
The amount of the external preparation composition impregnated into the sheet-like substrate (impregnation ratio) is preferably 2 to 8 times, more preferably 3 to 8 times, from the viewpoint of transferability of the external preparation composition to the skin. 3 to 5 times is most preferable.

<Packaging>
The skin sheet of the present invention is used in a state of being accommodated in a package. There is no restriction | limiting in particular as said package, The thing normally used for the sheet | seat for skin can be selected suitably, and can be used. For example, a material having a high barrier property such as a film on which an inorganic thin film is deposited, a resin film, an aluminum foil, or an aluminum deposited film can be used. Among these, a film on which an inorganic thin film is deposited is preferable in terms of barrier performance and deterioration.

<Application>
The skin sheet of the present invention can improve the skin function and provides a comfortable feeling during wiping (at least one of sweat and dirt, moisturizing feeling and refreshing feeling). It is suitably used for a sweat wipe sheet, a body sweat wipe sheet, a body deodorant sheet, a foot wipe sheet, a nursing wipe sheet, a sebum wipe sheet, a drowsiness alarm sheet, and the like.

  EXAMPLES Next, although an Example and a comparative example are given and this invention is demonstrated more concretely, this invention is not restrict | limited to the following Example.

(Examples 1 to 21 and Comparative Example 1)
<Manufacture of external preparation composition>
According to the composition and content described in Tables 1 to 4, external preparation compositions of Examples 1 to 21 and Comparative Example 1 were prepared by a conventional method.
The content of each component described in Tables 1 to 4 all represents mass%, and is a pure equivalent value. In addition, about pH of the external preparation composition, it measured according to the 16th revision Japanese Pharmacopoeia, a general test method, and a pH test method.

<Manufacture of skin sheet>
The external preparation compositions of Examples 1 to 21 and Comparative Example 1 were impregnated with 3 g of the external preparation composition with respect to 1 g of the nonwoven fabric in a 20 cm square non-woven fabric to obtain a skin sheet, which was subjected to the following evaluation. In addition, in Table 5, the commercial item name of the used nonwoven fabric was described.

<Evaluation>
The “low temperature stability (freezing / restoring property)” was evaluated for the external preparation compositions of Examples 1 to 21 and Comparative Example 1.
Among the skin sheets (medicine-containing skin sheets) containing each external preparation composition, Examples 1 to 3 and Comparative Example 1 were evaluated for “sweat wiping effect” and “cool feeling”. About Examples 4-21, "sweat wiping off effect", "cool feeling", "moisturizing feeling", and "effect of suppressing itching" were evaluated. All of these evaluations were performed under constant temperature and humidity conditions of a temperature of 25 ° C. and a humidity of 60% RH. The results are shown in Tables 1 to 4.

<< Low-temperature stability (freezing / restoring) >>
30 g of each of the prepared external preparation compositions was placed in a 30 mL glass vial, stored at −20 ° C. for 12 hours, and then stored at room temperature (25 ° C.) for 12 hours, and the appearance was visually observed. This cycle was repeated up to 4 times and evaluated according to the following evaluation criteria.
〔Evaluation criteria〕
AA: The liquid after 4 cycles is clear and colorless and no precipitation is observed. A: A precipitation is observed after 4 cycles. B: A precipitation is observed after 3 cycles. C: A precipitate is observed after 2 cycles. D: A precipitate is observed after 1 cycle. [Acceptance criteria] B or higher

<< Effect of sweat wiping >>
Eight evaluation panels were used to apply the prepared drug-containing skin sheet impregnated with each external preparation composition to the left front inner arm, and scored the effect of eliminating stickiness due to sweat immediately after wiping, based on the following scoring criteria. Subsequently, the average value of the scores of the eight evaluation panels was calculated and evaluated based on the following evaluation criteria.
[Scoring criteria]
5 points: No stickiness due to sweat 4 points: No stickiness due to sweat 3 points: None 2 points: Feeling stickiness due to sweat 1 point: Strong stickiness due to sweat [Evaluation criteria]
AA: The average value of sensory scores is 4.5 or more A: The average value of sensory scores is 3.5 or more and less than 4.5 points B: The average value of sensory scores is 2.5 or more and less than 3.5 points C : Average value of sensory score is 1.5 or more and less than 2.5 D: Average value of sensory score is less than 1.5 [acceptance standard] B or more

<< refreshing feeling >>
Eight evaluation panels applied the prepared drug-containing skin sheet impregnated with each external preparation composition to the left front inner arm, and scored the refreshing feeling immediately after wiping based on the following scoring criteria. Subsequently, the average value of the scores of the eight evaluation panels was calculated and evaluated based on the following evaluation criteria.
[Scoring criteria]
5 points: Feel strong 4 points: Feel 3 points: Neither 2 points: Not much feel 1 point: Not feel at all [Evaluation criteria]
AA: The average value of sensory scores is 4.5 or more A: The average value of sensory scores is 3.5 or more and less than 4.5 points B: The average value of sensory scores is 2.5 or more and less than 3.5 points C : Average value of sensory score is 1.5 or more and less than 2.5 D: Average value of sensory score is less than 1.5 [acceptance standard] B or more

<< Moisturizing feeling >>
Eight evaluation panels applied each drug-containing skin sheet impregnated with the external preparation composition of Examples 4 to 21 to the left front inner arm, and scored the moisturizing feeling immediately after wiping based on the following scoring criteria. Subsequently, the average value of the scores of the eight evaluation panels was calculated and evaluated based on the following evaluation criteria. The moisturizing feeling is a feeling that the skin feels immediately after the composition in the skin sheet is applied to the skin.
[Scoring criteria]
5 points: Feel strong 4 points: Feel 3 points: Neither 2 points: Not much feel 1 point: Not feel at all [Evaluation criteria]
AA: The average value of sensory scores is 4.5 or more A: The average value of sensory scores is 3.5 or more and less than 4.5 points B: The average value of sensory scores is 2.5 or more and less than 3.5 points C : Average value of sensory score is 1.5 or more and less than 2.5 D: Average value of sensory score is less than 1.5 [acceptance standard] B or more

<Effects to reduce itching>
Eight sensation panels that feel itching apply each drug-containing skin sheet impregnated with each of the external preparation compositions of Examples 4 to 21 to the itch-sensing site to prevent itching immediately after wiping. Based on the following scoring criteria, the combination of speed and the strength of the antipruritic effect was scored. Subsequently, the average value of the scores of the eight evaluation panels was calculated and evaluated based on the following evaluation criteria.
[Scoring criteria]
5 points: I don't feel itching at all 4 points: I don't feel itchy much 3 points: I can't say either 2 points: I feel a little itchy 1 point: I feel itching [Evaluation criteria]
AA: The average value of sensory scores is 4.5 or more A: The average value of sensory scores is 3.5 or more and less than 4.5 points B: The average value of sensory scores is 2.5 or more and less than 3.5 points C : The average value of sensory scores is 1.5 points or more and less than 2.5 points D: The average value of sensory scores is less than 1.5 points [acceptance criteria] B or more

* Precipitation of the external preparation composition of Comparative Example 1 was observed during storage.

  In addition, the specific content of the raw material of the external preparation composition used in Examples 1-21 and Comparative Example 1 is as shown below.

As an aspect of this invention, it is as follows, for example.
<1> An external preparation composition comprising (A) diphenhydramine hydrochloride, (B) allantoin, (C) glutyrrhizinate, and (D) ethanol.
<2> The external preparation composition according to <1>, further comprising (E) a polyhydric alcohol.
<3> The external preparation composition according to <2>, wherein the component (E) is 1,3-butylene glycol.
<4> Any one of <2> to <3>, wherein the mass ratio (D / E) of the content of component (D) to the content of component (E) is 5/1 to 1/5. It is an external preparation composition as described.
<5> The external preparation composition according to any one of <1> to <4>, further including (F) a surfactant.
<6> The external preparation composition according to <5>, wherein the component (F) is a nonionic surfactant.
<7> A skin sheet obtained by impregnating a sheet-like base material with the external preparation composition according to any one of <1> to <6>.

  The external preparation composition of the present invention contains diphenhydramine hydrochloride, allantoin, glycyrrhizinate and ethanol, gives a refreshing feeling when applied to the skin, and further wipes off the skin sheet impregnated with the external preparation composition. Since it can give a comfortable feeling of use (feeling that sweat and dirt have been wiped off and a refreshing feeling), it can be suitably applied to cosmetics, pharmaceuticals, quasi drugs, and the like.

Claims (7)

(A) diphenhydramine hydrochloride, (B) allantoin, (C) grayed Li Chirurichin salt, (D) ethanol, and (F) skin external composition containing a surfactant (provided that not containing salicylic acid) A sheet for skin characterized by impregnating a sheet-like base material.   The skin sheet according to claim 1, wherein the external preparation composition for skin further comprises (E) a polyhydric alcohol.   The skin sheet according to claim 2, wherein the component (E) is 1,3-butylene glycol.   The mass ratio (D / E) of the content of the component (D) and the content of the component (E) in the external preparation for skin is 5/1 to 1/5. The skin sheet as described in 2.   The skin sheet according to any one of claims 1 to 4, wherein the component (F) is a nonionic surfactant.   The skin sheet according to any one of claims 1 to 5, wherein the sheet-like base material contains at least one of cotton and rayon.   The skin sheet according to any one of claims 1 to 6, wherein an impregnation ratio of the external preparation composition for skin to the sheet-like base material is 2 to 8 times.