JP6350822B2 - Gel-like antibacterial agent - Google Patents

Description

  The present invention is installed in an air conditioner unit attached to passengers such as automobiles, trains, airplanes, ships, etc. or freight transporters, etc., and volatilizes active components over time, so that bacteria and molds generated in the air conditioner circuit can be obtained. The present invention relates to an antibacterial agent that suppresses the propagation of potato over a long period of time.

  Conventionally, as a preparation for suppressing the growth of microorganisms such as bacteria and fungi, antibacterial agents such as allyl isothiocyanate adsorbed or impregnated in porous materials or impregnated materials, which are mixed with a metal compound such as silver or copper as a base material What mix | blends the organic compound which has property is known well.

  In addition, as for the appearance of the antibacterial preparation, various types such as a solution, a paste, a gel, and a solid are known.

  For example, Patent Document 1 discloses a jelly-like antibacterial agent by adding a thickener to inorganic oxide fine particles such as silica / alumina containing an antibacterial metal compound such as silver oxide, and a method for producing the same. Yes.

Japanese Patent Laid-Open No. 2000-16907

  However, as disclosed in Example 2, the jelly-like antibacterial agent described in Patent Document 1 is premised on blending into a resin such as polypropylene resin or ABS, or rubber, and is used alone. Not intended, and its strength is very small.

  In addition, since the jelly-like antibacterial agent described in Patent Document 1 is blended into a resin or rubber, the period during which the antibacterial property can be maintained depends greatly on the blending amount and the like. It was necessary to consider various prescription designs depending on the target to be blended.

  Furthermore, in the jelly-like antibacterial agent described in Patent Document 1, the antibacterial metal compound needs to come into contact with microorganisms, and the air conditioner is attached to passengers such as automobiles, trains, airplanes, ships, or freighters. The antibacterial performance is not fully developed due to the accumulation of dirt such as dust and dirt in long-term use such as the unit where it is not usually cleaned. Also, even if an antibacterial organic compound is used instead of an antibacterial metal compound, it is difficult to maintain the antibacterial effect for a long period of time for such an air conditioner unit because the outside temperature varies greatly depending on the season. Met.

  Therefore, in the present invention, it can be used alone rather than blended with other objects, and it is usually used for passengers such as automobiles, trains, airplanes, ships, etc. that are not well-maintained or for transporting cargo. It aims at providing the antibacterial agent which can maintain an antibacterial effect over a long period with respect to the air-conditioner unit to which it is attached.

[1] That is, the present invention includes a phenolic compound having volatility, a gelling agent selected from waxes or fatty acid esters, and a compatibilizing agent having fluidity, and has a gel strength of 1 to 40 kgf. It is an antibacterial agent characterized by this.

  [2] The above [1], wherein the phenolic compound is contained in an amount of 10 to 90% by weight, the gelling agent is contained in an amount of 5 to 60% by weight, and the compatibilizing agent is contained in an amount of 5 to 60% by weight. Antibacterial agent.

  [3] The antibacterial agent according to [1] or [2], wherein the phenol compound has a volatilization amount of 0.1 to 10% by weight after 24 hours at 50 ° C. is there.

[4] The antibacterial agent according to any one of [1] to [3], wherein the elastic modulus is 0.5 to 6 Kgf / cm ² .

[5] Any one of [1] to [4] above, wherein the phenolic compound is at least one selected from parachlorometaxylenol and 3-methyl-4-isopropylphenol. The antibacterial agent described in 1.

[6] The antibacterial agent according to any one of [1] to [5], wherein the antibacterial agent is contained in a container having a volatilization outlet for discharging the phenolic compound.

[7] The antibacterial agent according to [6], wherein a ratio of an area of the volatilization port to a surface area of one surface of the container is 5 to 50%.

  According to the present invention, it can be used alone rather than blended with other objects, and is usually used for passengers such as automobiles, trains, airplanes, ships, etc. that are not well-maintained or for transporting cargo. The antibacterial effect can be maintained for a long time with respect to the air conditioner unit to be attached.

It is a front view of the container which accommodates the antibacterial agent of this invention. It is AA sectional view taken on the line of the container which accommodates the antibacterial agent of this invention.

  Hereinafter, embodiments relating to the antibacterial agent of the present invention will be described in detail. In addition, when there exists a description which shows the range in description, an upper limit and a lower limit are contained.

  The volatile phenol compound used in the present invention is an antibacterial compound having volatility at room temperature such as 25 ° C. Examples of the phenol compound include 4-chloro-3,5-dimethylphenol (parachlorometaxylenol), 4-chloro-3-methylphenol (parachlorometacresol), and 2,4,4′-trichloro-2. '-Hydroxydiphenyl ether, 3-methyl-4-isopropylphenol, 2-isopropyl-5-methylphenol, 2-benzyl-4-chlorophenol and the like are preferable. More preferred are 4-chloro-3,5-dimethylphenol (parachlorometaxylenol), 3-methyl-4-isopropylphenol and the like which do not show significant toxicity to humans or other mammals. Moreover, these phenol type compounds can be used individually or in combination of 2 or more types.

  The content of the phenolic compound in the present invention is preferably 10 to 90% by weight, more preferably 13 to 85% by weight, and most preferably 15 to 80% by weight. When the content ratio of the phenolic compound is within this range, the antibacterial effect can be maintained for a long time.

  The gelling agent used in the present invention is a compound for imparting a predetermined hardness to the present invention. Examples of the gelling agent include waxes such as bees wax, wool wax, whale wax, carnauba wax, candelilla wax, rice wax, wood wax, paraffin wax, microcrystalline wax, montan wax, ceresin, polyethylene wax, Fatty acid esters such as fatty acid dextrin and fatty acid inulin are preferred. Further, it is more preferable that the melting point is 70 to 150 ° C. so as to maintain a predetermined shape without melting even in a high temperature such as summer from the use environment. Moreover, these gelling agents can be used individually or in combination of 2 or more types.

  The content of the gelling agent in the present invention is preferably 5 to 60% by weight, and more preferably 5 to 55% by weight. When the content ratio of the gelling agent is within this range, it can be controlled to volatilize an appropriate amount to such an extent that the phenolic compound can exhibit antibacterial properties.

The compatibilizer having fluidity used in the present invention is an organic compound having fluidity by uniformly dissolving the phenol compound and the gelling agent so as not to bleed. As the compatibilizing agent, for example, saturated or unsaturated hydrocarbons having a chain structure or a cyclic structure such as alkane, alkene, alkyne and the like, alcohols, esters and the like are preferable. Further, liquid paraffin which is a kind of hydrocarbon is more preferable. And it is most preferable that it is a liquid paraffin whose flash point is 100-300 degreeC and whose kinematic viscosity is 4-80 mm < ² > / s. These compatibilizers can be used alone or in combination of two or more.

  The content of the compatibilizer in the present invention is preferably 5 to 60% by weight, and more preferably 10 to 50% by weight. When the content ratio of the compatibilizing agent is within this range, a sufficient amount of the phenol compound exhibiting antibacterial properties can be blended, and a shape having a predetermined strength can be maintained.

  And in order to prevent deterioration by oxidation of the said phenolic compound etc. in the antibacterial agent of this invention, vitamin C (ascorbic acid), vitamin E (tocophenol), BHT (dibutylhydroxytoluene), BHA (butylhydroxyanisole) An antioxidant such as can be added. Moreover, a fragrance | flavor can also be mix | blended. By blending a fragrance, not only the effect of relaxing a passenger's feelings by drifting a predetermined scent in passenger transport such as automobiles, trains, aircraft, ships, etc., but also antibacterial properties when the scent disappears It also has an effect as an indicator that informs when it will drop and replace.

  The antibacterial agent of the present invention obtained by blending the above various components has a gel-like property. When the hardness of the gel-like antibacterial agent is shown as the gel strength, it is preferably 1 to 40 kgf, more preferably 2 to 35 kgf. When the gel strength is within this range, when attached to an air conditioner unit attached to passengers such as automobiles, trains, airplanes, ships, etc. The phenolic compound can be volatilized to such an extent that it exhibits antibacterial properties.

And it is preferable that the elasticity modulus which is a physical-property value showing the difficulty of a deformation | transformation of the antibacterial agent of this invention is 0.5-6Kgf / cm < ² >, and is 0.33-5.83Kgf / cm < ² >. Is more preferable. When the elastic modulus is in this range, when attached to an air conditioner unit attached to passengers such as automobiles, trains, airplanes, ships, etc. or cargo transportation equipment, no loss or destruction occurs due to vibration during movement, The phenolic compound can be volatilized to such an extent that it exhibits antibacterial properties.

  Furthermore, in the antibacterial agent of the present invention, the volatilization amount of the phenolic compound after 24 hours at 50 ° C. is preferably 0.1 to 10% by weight of the blended phenolic compound, 0.2 to It is more preferably 7.0% by weight, and most preferably 0.3 to 5.0% by weight. When the volatilization amount of the phenolic compound under this condition is within this range, the phenolic compound can be gradually released to the outside, and antibacterial properties can be exhibited over a long period of time.

  Moreover, as shown in FIGS. 1 and 2, the antibacterial agent a of the present invention is preferably used by being housed inside a container 1 having a substantially rectangular shape or the like. The container 1 includes a container body 2 and a lid 3, and a plurality of substantially rectangular volatilization ports 31 are perforated on the surface of one side of the lid 3, for example, condensation inside the air conditioner unit. It is attached to the ventilation path near the evaporator. The phenolic compound is discharged to the outside from the volatilization port 31, and microorganisms such as bacteria and mold can be prevented from breeding inside the air conditioner unit. When fitting and attaching the container 1 containing the antibacterial agent a so as to be embedded in the air conditioner unit, the volatilization port 31 is preferably perforated only on one side surface of the lid 3. Moreover, it is preferable that the container 1 consists of raw materials, such as resin, such as a polypropylene, a polyethylene terephthalate, and a polycarbonate. The volatilization port 31 is not limited to the illustrated rectangular shape, but may be various shapes such as a circle, an ellipse, a rectangle, and a star, and the number thereof may be variously selected.

  As shown in FIGS. 1 and 2, a volatilization port 31 is provided on the surface of one side surface of the lid 3 constituting the container 1, and the ratio of the total area of the volatilization port to the surface area of the surface is 18%. It is. The ratio of the area of the volatilization port 31 to the surface area of one surface of the container is preferably 5 to 50%, and more preferably 10 to 45%. When the proportion of the total area of the volatilization port 31 is within this range, the phenolic compound can be released to the outside of the container without excess or deficiency, and antibacterial properties can be exhibited over a long period of time.

  Next, the Example regarding the antibacterial agent of this invention is described in detail. In addition, the antibacterial agent of this invention is not limited to the said Example.

Example 1
As the phenolic compound, 30% by weight of parachlorometaxylenol, 20% by weight of rice wax as the gelling agent, and 50% by weight of liquid paraffin having a kinematic viscosity of about 5 mm ² / s as the compatibilizing agent are mixed uniformly. The mixture was stirred until a gel antibacterial agent was prepared.

(Example 2)
In the same manner as in Example 1, 50% by weight of parachlorometaxylenol, 30% by weight of dextrin palmitate, and 20% by weight of liquid paraffin having a kinematic viscosity of about 8 mm ² / s are mixed and stirred until uniform to form a gel-like antibacterial agent. An agent was prepared.

(Example 3)
In the same manner as in Example 1, 70% by weight of parachlorometaxylenol, 10% by weight of rice wax, and 20% by weight of liquid paraffin having a kinematic viscosity of about 14 mm ² / s are mixed and stirred until uniform to form a gel-like antibacterial agent Was prepared.

Example 4
As in Example 1, 50% by weight of 3-methyl-4-isopropylphenone, 5% by weight of rice wax, and 45% by weight of liquid paraffin having a kinematic viscosity of about 35 mm ² / s were mixed and stirred until uniform to obtain a gel. An antibacterial agent was prepared.

(Example 5)
In the same manner as in Example 1, 80% by weight of parachlorometaxylenol, 10% by weight of rice wax, and 10% by weight of liquid paraffin having a kinematic viscosity of about 78 mm ² / s are mixed and stirred until uniform to form a gel-like antibacterial agent Was prepared.

(Example 6)
As in Example 1, 15% by weight of parachlorometaxylenol, 45% by weight of rice wax, and 40% by weight of liquid paraffin having a kinematic viscosity of about 35 mm ² / s are mixed and stirred until uniform to form a gel-like antibacterial agent Was prepared.

(Comparative Example 1)
As in Example 1, 5% by weight of parachlorometaxylenol, 90% by weight of rice wax, and 5% by weight of liquid paraffin with a kinematic viscosity of about 68 mm ² / s were mixed and stirred until uniform to form a gel-like antibacterial agent Was prepared.

(Comparative Example 2)
In the same manner as in Example 1, 10% by weight of parachlorometaxylenol and 90% by weight of rice wax were mixed and stirred until uniform to prepare a gel-like antibacterial agent.

(Comparative Example 3)
In the same manner as in Example 1, 10% by weight of parachlorometaxylenol, 5% by weight of rice wax, and 85% by weight of propylene glycol monomethyl ether were mixed and stirred until uniform to prepare a gel-like antibacterial agent.

(Comparative Example 4)
In the same manner as in Example 1, 5% by weight of parachlorometaxylenol, 2.5% by weight of rice wax, and 92.5% by weight of liquid paraffin having a kinematic viscosity of about 5 mm ² / s were mixed and stirred until uniform. An antibacterial agent was prepared.

(Comparative Example 5)
In the same manner as in Example 1, 5% by weight of parachlorometaxylenol, 10% by weight of hydroxystearic acid, and 85% by weight of liquid paraffin having a kinematic viscosity of about 5 mm ² / s were mixed and stirred until uniform to form a gel-like antibacterial agent. An agent was prepared.

  Table 1 shows a summary of the blending components and blending amounts of these Examples and Comparative Examples.

  And in the antibacterial agents obtained in these examples and comparative examples, gel strength, elastic modulus, evaluation of physical properties such as volatilization amount of the phenolic compound after 24 hours at 50 ° C., and antibacterial properties, sustainability, etc. Performance evaluation was performed. The evaluation method followed the method shown below.

(1) Gel strength Using a digital force gauge (DPRSX-20R, φ15 mm attachment) manufactured by Imada Co., Ltd., the load (Kgf) when the gel-like antibacterial agent is pushed in with the attachment is read from the scale. The gel strength was determined as the hardness of the antibacterial agent.

(2) Elastic modulus From the measured gel strength, the elastic modulus E was calculated by the following method <1> by the method of Timoschenko et al.
E = {P (1-ν ² )} / (2aΔh) <1>
In the above formula <1>, P: indentation load, ν: Poisson's ratio, a: attachment radius, Δh: attachment sinking amount. As for the Poisson's ratio, the antibacterial agents of Examples and Comparative Examples are compared with general resins. It was 0.5 because of its softness and large deformability.

(3) The antibacterial agent of each Example and Comparative Example in which the volatilization amount of the volatile phenol compound after 24 hours at 50 ° C. was adjusted was allowed to stand for 24 hours under the condition of 50 ° C., before the start of the test. The weight loss was measured as a volatile phenolic compound, and was calculated as a percentage by weight relative to the volatile phenolic compound contained in the antibacterial agent before the start of the test.

(4) A container made of polypropylene provided with an antibacterial volatilization port, filled with the gel-like antibacterial material of Examples and Comparative Examples, and a petri dish inoculated with A. niger in a medium, It put into a 3L desiccator and left still at 27 degreeC for 24 hours. Thereafter, the petri dishes were taken out and cultured at 27 ° C. for 5 days to visually check the growth of Aspergillus niger and judged according to the following criteria.
○: The occurrence of colonies in the medium could not be confirmed and the growth was clearly suppressed. Δ: The occurrence of colonies in the medium could be confirmed, but there was not much propagation. ×: The occurrence of colonies in the medium could be confirmed and spread throughout the medium. A lot of breeding

(5) Sustainability The gel-like antibacterial material was placed in a thermostatic bath at 50 ° C. and stored for 3 months, the antibacterial property of (4) was confirmed, and the sustainability of the effect was evaluated according to the same criteria.

  Table 2 shows a summary of various performances of these examples and comparative examples.

  From the results shown in Table 2, a phenolic compound having volatility, a gelling agent, and a compatibilizing agent having fluidity are provided, and as shown in Examples 1 to 6, the gel strength and the like are adjusted to a predetermined range. By controlling the volatilization amount of the phenolic compound, it can be seen that the antibacterial property is developed continuously over a long period of time. It was confirmed that the effect could be sustained. On the other hand, in Comparative Examples 1 and 2, if the gel strength is high (the gel strength exceeds the measurement limit of 40), the phenolic compound is difficult to volatilize, the antibacterial property is not good at x or Δ, and the durability is also good. Both were bad at x. Further, in Comparative Examples 3 to 5, if the gel strength is small, the phenolic compound is easily volatilized and the antibacterial property is good with good, but the sustainability is not good with x, and there is a need to frequently replace it. Therefore, it was judged that the air conditioner unit could not be used comprehensively.

DESCRIPTION OF SYMBOLS 1 ... Container 2 ... Container body 3 ... Lid 31 ... Volatilization opening a ... Antibacterial agent

Claims (7)

An antibacterial agent comprising a phenolic compound having volatility, a gelling agent selected from waxes or fatty acid esters, a compatibilizing agent having fluidity, and a gel strength of 1 to 40 kgf. The antibacterial agent according to claim 1, wherein the phenolic compound is contained in an amount of 10 to 90% by weight, the gelling agent is contained in an amount of 5 to 60% by weight, and the compatibilizing agent is contained in an amount of 5 to 60% by weight. The antibacterial agent according to claim 1 or 2, wherein the amount of volatilization of the phenolic compound after 24 hours at 50 ° C is 0.1 to 10% by weight of the blended phenolic compound. Antimicrobial agents as claimed in any one of claims 1 to 3, wherein the elastic modulus is 0.5~6Kgf / cm ^2. The antibacterial agent according to any one of claims 1 to 4, wherein the phenolic compound is at least one selected from parachlorometaxylenol or 3-methyl-4-isopropylphenol. The antibacterial agent according to any one of claims 1 to 5, wherein the antibacterial agent is contained in a container having a volatilization port for discharging the phenolic compound. The antibacterial agent according to claim 6, wherein a ratio of an area of the volatilization port to a surface area of one surface of the container is 5 to 50%.

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