JP6422107B2 - Container drink - Google Patents

Description

  The present invention relates to a packaged beverage in which a beverage for improving xerostomia is packed in a container, and more particularly to a plastic bottle packaged beverage suitable for improving xerostomia in elderly people.

  Japan is facing an aging society like no other in the world, and the aging rate is expected to rise until around 2050. Changes in the structure of the disease are observed in the oral cavity as demographic changes occur, and the dry mouth (dry mouth), which greatly reduces the quality of life (QOL) of elderly people, especially those requiring nursing care Increase is considered a serious problem.

  Xerostomia is distinct from dry mouth dryness where the hard and smooth oral tissues such as teeth and soft tissues such as gums, tongue, and buccal mucosa lose their moisture and dryness. The Dry mouth dryness occurs even when a healthy person exercises and sweats, and pathologically, for example, it occurs with excessive sweating due to hyperthyroidism. The cause of dry mouth is relatively clear and is often resolved by treating the disease and drinking water.

  However, dry mouth is complicated by factors such as a decrease in salivary secretion due to salivary gland atrophy with age, dentures, long-term treatment, and continued mental tension. In many cases, it is more common in older people than younger people, and diagnosis and treatment are relatively difficult.

  Symptoms of xerostomia are diverse, such as (1) burning sensation in the oral cavity, tongue sticking, inflammation of the oral and lip mucosa, such as peeling of the lips, (2) difficulty in talking, swallowing food, Functional disorders such as easy removal of complete dentures, (3) Taste disorders that make it difficult to understand the taste of food, (4) Occurrence of wrinkles and cracks in the buccal mucosa and lip mucosa, atrophy of the tongue papillae and smoothing of the tongue back (5) Since the self-cleaning action by saliva is reduced, plaque and food residues adhere to the teeth and surrounding mucous membranes, periodontal disease and touch, increased bad breath, etc. Contamination, and (6) coexisting morbidity such as formation of wrinkles and ulcers that are difficult to cure on the corners of the mouth, and oral candidiasis.

  In Japan, it is said that about 50% of the elderly in the first half and about 60% of the elderly in the second half are admitted to dry mouth, and similar reports have been made in other developed countries. Decreased saliva results in decreased oral function such as mastication and swallowing. When other diseases such as the cardiovascular system and central nervous system are combined, the effects on daily living activities (ADL) and QOL are further affected. Improvement of xerostomia is extremely important because it becomes prominent.

  Various drugs or compositions have been developed for the purpose of improving xerostomia. For example, Patent Document 1 discloses a composition for xerostomia containing lactic acid bacteria and xylitol as active ingredients. . Patent Document 2 describes a dry mouth ameliorating agent containing water, polyhydric alcohol, hydroxypropylcellulose, hypromellose and polyvinylpyrrolidone. Patent Document 3 describes a therapeutic agent for xerostomia comprising a spirooxathiolanquinuclidine derivative or an acid addition salt thereof as an active ingredient. Patent Document 4 describes a composition for treating xerostomia comprising olive oil, trimethylglycine, and xylitol.

  The composition for xerostomia described in Patent Document 1 is used in the form of a food such as chewing gum, candy or chocolate or a composition for oral cavity. Moreover, the dry mouth ameliorating agent described in Patent Document 2 is used as a mouthwash or a mouthwash. Further, the therapeutic agent for xerostomia described in Patent Document 3 is orally administered in a solid composition such as a capsule, tablet, powder, granule or troche, or in a liquid composition such as syrup or suspension. Used in. The composition for treating xerostomia described in Patent Document 4 is used as a toothpaste, a mouth rinse, saliva substitute, spray, gel, chewing gum, tablet, confectionery, impregnated oral gauze.

JP 2004-115464 A JP 2009-242349 A JP-A-8-12575 Special table 2010-519279 gazette

  However, it is extremely difficult to improve dry mouth in elderly people with these above-mentioned conventional techniques. This is because in the use of the spray form, it is difficult for the elderly to perform the spray operation accurately into the oral cavity, and in some cases, the pharyngeal irritation of the spray is strong and the cough reflex and the vomiting reflex occur. May be encouraged. In addition, in the use of toothpastes, mouth washes, mouth washes, and mouthwashes, the function of the oral muscle tissue may be reduced in the elderly, and these mouthwashes may be removed from the mouth after use. It is difficult to exhale. In addition, solid compositions such as capsules, tablets, powders, granules, and troches, or liquid compositions such as syrups and suspensions, usually use a large amount of regular medicines for the elderly. Therefore, in many cases, the use of drugs already has an aversion, and it is difficult to promote improvement of xerostomia in the elderly in such a use form. In addition, in the use of food forms such as chewing gum and candy, in the case of elderly people, the function of chewing in the oral cavity and the function of rolling licking may be reduced, and the active ingredient that exudes from chewing gum etc. is spread throughout the oral cavity Is difficult. As described above, there are few methods for accurately improving dry mouth in the elderly, and there is a strong demand for such a method in the recent aging society.

  This invention is made | formed in view of this problem, Comprising: It aims at providing the container-packed drink which improves the xerostomia of elderly people exactly.

  The container-packed beverage according to the present invention is filled with an oral dryness-improving beverage for improving xerostomia in a container that is closed by a lid that can be repeatedly sealed and opened. It is characterized by being.

  The packaged beverage of the present invention is suitable for improving xerostomia in the elderly and is expected to improve compliance (the patient can take the medicine as prescribed). Here, an elderly person is not particularly limited, but refers to a person who is, for example, a person 60 years or older and who regularly has dry mouth due to aging. In addition, xerostomia (also referred to as dry mouth) is a dental disease classified as an oral mucosal disease, in which the amount of saliva secretion decreases and the oral cavity becomes dry, It also includes a broad sense of dry mouth (dry mouth) that complains of dry mouth as a subjective symptom.

  The container is preferably a plastic bottle container.

  The xerostomia-improving beverage is composed of hyaluronic acid or a pharmaceutically acceptable salt thereof, collagen, polyglutamic acid or a pharmaceutically acceptable salt thereof, poly-γ-glutamic acid or a pharmaceutically acceptable salt thereof, propylene It is preferable to contain a moisturizing component containing at least one of glycol, hydrolyzed hydrogenated starch, and milk protein extract.

  The xerostomia-improving beverage is a saliva secretion promoting component having an organic acid containing at least one of citric acid, malic acid, tartaric acid, fumaric acid and succinic acid, or a pharmaceutically acceptable salt thereof. It is preferable to contain.

  The xerostomia-improving beverage preferably contains a saliva component containing at least one of sodium chloride, potassium chloride, calcium chloride, magnesium chloride, and dipotassium phosphate.

  The xerostomia-improving beverage is lysozyme, lysozyme chloride, lactoferrin, histatin, peroxidase, sialoperoxidase, myeloperoxidase, agglutinin, defensin, lactoperoxidase, glucose oxidase, potassium thiocyanate, beta D glucose, and immunoglobulin. It is preferable to contain a cleaning auxiliary component containing at least one of them.

  The xerostomia ameliorating beverage is at least one of sugar alcohols such as xylitol, erythritol, sorbitol, mannitol, reduced lactose, reduced maltose starch syrup, reduced starch syrup, propylene glycol, 1,3-butylene glycol, polyethylene glycol, and glycerin. It is preferable to contain a polyhydric alcohol including any one of them.

  The xerostomia-improving beverage preferably contains a water-soluble polymer substance containing at least one of sodium carboxymethylcellulose, polyvinylpyrrolidone, xanthan gum, carrageenan, and sodium alginate.

  In addition, the dry mouth improvement beverage is glucosamine, chondroitin, lutein, folic acid, fatty acid, fruit extract, vegetable extract, vitamin preparation, mineral preparation, phosphatidylserine, lipoic acid, melatonin, aloe vera, google ( Guggul), amino acids, lycopene, herbs, catechins, caffeine, fruit flavonoid constituents, evening primrose oil, and linseed oil.

  ADVANTAGE OF THE INVENTION According to this invention, dry mouth of elderly people can be improved exactly. As a result, the chewing function, swallowing function, and articulation function of the elderly can be improved, and the communication ability indispensable for ADL and QOL and social life can be maintained.

  Hereinafter, embodiments of the present invention will be specifically described. However, the embodiments are for facilitating understanding of the principle of the present invention, and the scope of the present invention is not limited to the following embodiments. In addition, other embodiments in which those skilled in the art appropriately replace the configurations of the following embodiments are also included in the scope of the present invention.

  As a result of earnestly studying the elderly's propensity as to how the elderly can take the xerostomia-improving ingredient accurately and comfortably, the present inventors have found that xerostomia improves xerostomia. The present invention has been completed by finding that the improved beverage is filled into the container through the opening (bottle opening) of the container, and the container-packed beverage having the opening closed with a lid that can be repeatedly sealed and opened is optimal.

  In other words, there is a habit of not accepting new ones for the elderly and accepting familiar ones that are familiar to us on a daily basis. In the case of an elderly person, for example, a bottle that can be repeatedly carried and has a lid that can be repeatedly sealed and opened, such as a plastic bottle container, is filled with tea or the like and carried on a daily basis. Since this dry-packed container-packed beverage contains a dry mouth improving component, it is possible to inoculate the dry mouth improving component without feeling uncomfortable against the elderly's propensity. In addition, since elderly people usually use a large amount of regular medicines on a daily basis, they often feel disgusted about drug use. Since the possibility of having an image of a drug is extremely low if it contains an improving component, it is possible to inoculate the dry mouth improving component without having a rejection reaction. Also, it does not require vaccination skills such as spraying, does not require vomiting after use like mouthwashes and mouthwashes, and requires oral motor functions such as biting and licking. It is not a thing, but because it is a beverage form that is a simple operation, it is possible to accurately inoculate the dry mouth improving component. In addition, it is not like a single-use unit bottle, but because the mouth dry beverage is filled in a packaged beverage whose opening is closed with a lid that can be repeatedly sealed and opened, the elderly can carry it anywhere. Each time you feel dry, you can open the lid and apply the opening to the mouth to use as much as you need. Furthermore, in the case of elderly people, there is a tendency to easily suffer from heat stroke due to a decrease in body temperature regulation function, etc. According to the present invention, it is effective in preventing heat stroke as a secondary effect. It is also effective in preventing dehydration in the elderly.

  The container filled with the dry mouth improvement beverage is not particularly limited as long as it is suitable for carrying by the elderly, and various containers such as light metal containers such as aluminum and paper pack containers are used. For example, a plastic container is preferable because it is lightweight, inexpensive and durable. The plastic container is not particularly limited, and various kinds of plastic containers are used. Among them, a plastic bottle container is preferable because elderly people often carry it as described above. The PET bottle container is a container formed from polyethylene terephthalate (PET) resin. The lid of the container is not particularly limited as long as it can be repeatedly sealed and opened and can maintain the quality of the dry mouth improvement beverage, but for example, a screw lid can be used.

  The xerostomia-improving beverage to be filled in the container is not particularly limited. For example, hyaluronic acid or a pharmaceutically acceptable salt thereof, collagen, polyglutamic acid or a pharmaceutically acceptable salt thereof, poly -It is possible to contain a moisturizing ingredient including at least one of γ-glutamic acid or a pharmaceutically acceptable salt thereof, propylene glycol, hydrolyzed hydrogenated starch, and milk protein extract. In particular, when using at least one of hyaluronic acid or a pharmaceutically acceptable salt thereof and collagen, not only the improvement of xerostomia, but also the effect of maintaining the moisture retention and elasticity of the skin is obtained, and the skin becomes rough. Since it can prevent and improve fine lines and wrinkles, it is also suitable for cosmetic purposes.

  The origin of hyaluronic acid or a pharmaceutically acceptable salt thereof is not particularly limited, and hyaluronic acid separated and purified from chicken crowns, umbilical cords, microorganisms producing hyaluronic acid, and the like can be used. Examples of pharmaceutically acceptable salts of hyaluronic acid include salts with inorganic bases such as alkali metal salts (sodium salt, lithium salt, potassium salt, etc.), alkaline earth metal salts, ammonium salts, or diethanolamine salts, Among salts with organic bases such as cyclohexylamine salts and amino acid salts, pharmaceutically acceptable salts can be used. The weight average molecular weight of hyaluronic acid or a pharmaceutically acceptable salt thereof is not particularly limited, but is preferably about 200,000 to 2,000,000, more preferably about 400,000 to 1,400,000, and particularly preferably about 500,000 to 1,200,000. . Moreover, hyaluronic acid or a pharmaceutically acceptable salt thereof preferably has an intrinsic viscosity of 10 to 26 dl / g, more preferably 12 to 22 dl / g, and particularly preferably 10 to 14 dl / g. The concentration of hyaluronic acid or a pharmaceutically acceptable salt thereof is not particularly limited and is set with appropriate consideration of ease of drinking of the elderly, for example, 0.001 to 5% (w / v) More preferably, it is about 0.01-3% (w / v), More preferably, it is about 0.05-1% (w / v), Most preferably, it is 0.1-0.4%. It is about (w / v).

  The origin of collagen is not particularly limited. For example, collagen having an average molecular weight of about 300 to 30,000 obtained by hydrolyzing gelatin extracted from bones or tendons of animals such as cows and pigs with enzymes or acids, preferably Is about 700 to 20,000, particularly preferably about 1000 to 10,000. Alternatively, the average molecular weight obtained by reducing the molecular weight of collagen extracted from fish skin, fish bone, fish scale, cow skin, cow bone, pig skin, pig bone, pig liver, etc. by hydrolysis similar to the above is 500 to 20,000. A peptide having a molecular weight of about 1,000, preferably about 10,000 to 10,000, particularly preferably about 2,000 to 8,000. In addition, when collagen is contained, it is desirable to mask the fishy and animal odors of the collagen peptide. For example, masking may be performed using the fruit flavor of peach, orange, muscat, etc. Is possible. The concentration of collagen is not particularly limited and is set taking into consideration the ease of drinking of the elderly as appropriate, but is preferably 0.001 to 4% (w / v), more preferably 0.01 to It is about 3% (w / v), more preferably about 0.05 to 2% (w / v), and particularly preferably about 0.2 to 1.2% (w / v).

  The polyglutamate is not particularly limited. For example, a sodium or potassium salt of α or γ-polyglutamic acid that is chemically synthesized, or natural α or γ- obtained as a fermentation product from various strains. Sodium or potassium salt of polyglutamic acid can be used, but natural sodium or potassium salt of polyglutamic acid is preferable because it is used for oral use. Particularly, sodium or potassium salt of γ-polyglutamic acid having high productivity as a raw material is more preferable. Is preferred. The concentration of polyglutamate is not particularly limited and is set in consideration of the ease of drinking of the elderly as appropriate. For example, it is 0.01 to 5% (w / v), preferably 0.1. It is -3% (w / v), Most preferably, it is 0.2-1% (w / v). The viscosity of the polyglutamate is not particularly limited, and is preferably in the range of, for example, 10 to 220 mPa · s, particularly 30 to 120 mPa · s.

  In addition, the xerostomia improving beverage is not particularly limited. For example, an organic acid containing at least one of citric acid, malic acid, tartaric acid, fumaric acid and succinic acid, or a pharmaceutically acceptable salt thereof. It is possible to contain a salivary secretion-promoting component having a salt formed. Although these salts are not particularly limited, for example, salts such as Na, K, Ca, Mg, and amine, and chelate substances bound with Fe, Al, and the like are also included. The concentration of these salivary secretion-promoting components is not particularly limited, but for example 0.01 to 6% (w / v), preferably 0.1 to 4% (w / v), particularly preferably 0.2. ~ 1% (w / v).

  In addition, the dry mouth improving beverage is not particularly limited, but includes, for example, a saliva component containing at least one of sodium chloride, potassium chloride, calcium chloride, magnesium chloride, and dipotassium phosphate. Is possible. By containing such an inorganic electrolyte component composition, a component similar to human normal saliva can be obtained. The concentration of sodium chloride is not particularly limited, but is, for example, 0.01 to 0.5% (w / v), preferably 0.02 to 0.2% (w / v), and more preferably Is 0.03 to 0.1% (w / v). The concentration of potassium chloride is not particularly limited, but is, for example, 0.01 to 0.3% (w / v), preferably 0.02 to 0.2% (w / v), and more Preferably, it is 0.1 to 0.15% (w / v). The concentration of calcium chloride is not particularly limited, but is, for example, 0.001 to 0.05% (w / v), preferably 0.005 to 0.03% (w / v), and more Preferably it is 0.01 to 0.02% (w / v). The concentration of magnesium chloride is not particularly limited, but is, for example, 0.001 to 0.01% (w / v), preferably 0.002 to 0.008% (w / v), and more Preferably it is 0.004 to 0.006% (w / v). The concentration of dipotassium phosphate is not particularly limited, but is, for example, 0.001 to 0.08% (w / v), preferably 0.006 to 0.06% (w / v). More preferably, it is 0.01 to 0.04% (w / v).

  In addition, the dry mouth improvement beverage is not particularly limited. It is possible to contain a cleaning auxiliary component containing at least one of beta D glucose and immunoglobulin. For example, lysozyme has a function of acting on and decomposing bacterial cell walls, and when the cell walls are degraded, the cells naturally begin to lyse, and consequently suppress bacterial growth. For example, lysozyme chloride digests the cell wall of bacteria by hydrolyzing the glycosidic bond of peptidoglycan and dissolves bacteria. In addition, for example, lactoferrin has a function of binding to ferric ions in the oral cavity, and ferric ions are necessary components for the growth of bacteria. Can be suppressed.

  In addition, the dry mouth improvement beverage is at least any of sugar alcohols such as xylitol, erythritol, sorbitol, mannitol, reduced lactose, reduced maltose starch syrup, reduced starch syrup, propylene glycol, 1,3-butylene glycol, polyethylene glycol, and glycerin. It is possible to contain a polyhydric alcohol including one of them. The concentration of these polyhydric alcohols is not particularly limited, but is, for example, 0.01 to 10% (w / v), preferably 0.04 to 6% (w / v), and more preferably. Is 0.2-2% (w / v).

  Moreover, the dry mouth improvement drink can contain a water-soluble polymer substance containing at least one of sodium carboxymethylcellulose, polyvinylpyrrolidone, xanthan gum, carrageenan, and sodium alginate. The concentration of these water-soluble polymer substances is not particularly limited, but is, for example, 0.001 to 4% (w / v), preferably 0.004 to 2% (w / v), More preferably, it is 0.01 to 1% (w / v).

  In addition, dry mouth improvement beverages include glucosamine, chondroitin, lutein, folic acid, fatty acid, fruit extract, vegetable extract, vitamin, mineral, phosphatidylserine, lipoic acid, melatonin, Aloe Vera, Google (Guggul ), Amino acids or salts thereof, lycopene, herbs, catechins, caffeine, fruit flavonoid constituents, evening primrose oil, and linseed oil.

  Although it does not specifically limit as a vitamin agent, For example, vitamin A, vitamin B, vitamin E, vitamin D, etc. can be contained. Examples of vitamin B include vitamin B group selected from inositol, thiamine hydrochloride, thiamine nitrate, riboflavin, sodium riboflavin 5'-phosphate, niacin, nicotinamide, calcium pantothenate, pyridoxy hydrochloride, and cyanocobalamin. Further, the mineral agent is not particularly limited, but for example, calcium, chromium, copper, fluorine, iodine, iron, magnesium, manganese, phosphorus, selenium, silicon, molybdenum and zinc can be contained. Preferred minerals are magnesium, phosphorus and iron.

  In addition, the herb is not particularly limited, for example, anise, star anise, laurel, lavender, sage, coriander, fennel, hyssop, oregano, peppermint, rosemary, spear mint, caraway, orange peel, It is possible to use scented herbs such as lemon peel, willow, jasmine, basil, and citron skin. Also, for example, Agrimony, Arbens, Betony, Burdock, Clove, Juniper, Costmary, Dog Rose, Ele Campaign, Ibright, Gentian, Grand Ivy, Magwort, Lou, St. John's Wort, Wormwood, Yarrow, Arcanet Flavoring herbs such as Penny Royal, Hibiscus, Stevia, Lemongrass, Lemon Balm, Chamomile, Ginger, Thyme, Pepper, Mallow Blue, and Linden can be used.

  The amino acid is not particularly limited, and for example, arginine, ornithine, cysteine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, valine, and histidine can be contained. In particular, nine amino acids such as isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, valine and histidine cannot be synthesized in the human body and are known to be contained as they are known as essential amino acids for the human body. . As amino acid salts, inorganic acids (eg, hydrobromic acid, hydrochloric acid, sulfuric acid, phosphoric acid, nitric acid), organic acids (eg, propionic acid, acetic acid, succinic acid, glycolic acid, lactic acid, malic acid, tartaric acid, citric acid) Acid addition salts with maleic acid, fumaric acid, methanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid, ascorbic acid); alkali metals (for example, sodium, potassium), alkaline earth metals (for example, calcium), Salts with inorganic bases such as ammonium; salts with organic bases such as amines (eg, methylamine, diethylamine, triethylamine, ethylenediamine) and alkanolamines (eg, monoethanolamine, diethanolamine, triethanolamine), and the like. The concentration of the amino acid or a salt thereof is not particularly limited as long as a suitable flavor and physiological effect can be obtained. For example, 0.01 to 5.6% (w / v), preferably 0.04 to It is 3.8% (w / v), more preferably 0.2 to 2.2% (w / v).

  The catechins are any of non-epimeric catechins such as catechin, gallocatechin, catechin gallate, and gallocatechin gallate, and epimeric catechins such as epicatechin, epigallocatechin, epicatechin gallate, and epigallocatechin gallate. Is also contained. By containing catechins, it is possible to suitably obtain a cholesterol elevation suppressing action, an amylase activity inhibiting action, and the like. In addition, liver function (GOT, GPT, etc.) can be improved. The concentration of catechins is not particularly limited as long as a suitable flavor and physiological effect can be obtained. For example, 0.02 to 0.6% (w / v), preferably 0.04 to 0 .4% (w / v), more preferably 0.08 to 0.2% (w / v).

  Caffeine is caffeine or a mixture of caffeine and a caffeine derivative. Caffeine is obtained, for example, from an extract of coffee beans, guarana, cocoa or the like, or a concentrate of the extract. For example, it is obtained by extraction from tea leaves obtained from the genus Camellia, such as C. sinensis, C. assaimica, or hybrids thereof.

  The above-described moisturizing component, saliva secretion promoting component, saliva component, cleaning auxiliary component, polyhydric alcohol, water-soluble polymer substance, and medium for dissolving the nutritional auxiliary component are not particularly limited, but for example, water, buffer solution , Physiological saline or the like can be used.

  To the dry mouth improving beverage, other substances can be added as appropriate as long as the dry mouth improving property is maintained, and examples thereof include additives and pharmacologically active ingredients.

  Additives include colorants, buffers, isotonic agents, preservatives, stabilizers, pH adjusters, emulsifiers, solubilizers, suspending agents, dispersants, bases, thickeners, sweeteners. Examples include those usually used in medicine, such as flavoring agents, flavoring agents, and refreshing agents.

  For example, examples of the buffer include phosphate buffer, Tris buffer, and acetate buffer. Examples of the pH adjuster include hydrochloric acid, sodium hydroxide, sodium monohydrogen phosphate, sodium dihydrogen phosphate and the like. Examples of tonicity agents include glucose, D-mannitol, fructose, sodium dihydrogen phosphate, sodium phosphate and the like. Stabilizers include acetic acid, glycine, lactic acid or salts thereof (sodium salt, potassium salt, calcium salt, lithium salt, ammonium salt, etc.), iodine-containing reducing agents (potassium iodide, sodium iodide, etc.) Compounds), sulfur-containing reducing agents (metal thiosulfates such as potassium thiosulfate and sodium thiosulfate, thiocyanate metal salts such as potassium thiocyanate and sodium thiocyanate, thiourea, thiosemicarbazide, thiopental, etc. Thioketones and sulfides such as L-methionine). Examples of the preservative include paraoxybenzoic acid ester (paraben), potassium sorbate, sodium benzoate, chlorhexidine gluconate and the like. Examples of the corrigent include ascorbic acid, copper chlorophyllin sodium, kumazasa extract, orange oil, lemon oil, rose oil and the like. Examples of the refreshing agent include 1-menthol, camphor, mint oil and the like.

  Examples of the flavor include peppermint oil, spearmint oil, thymol, hinokitiol, lavender oil and the like, and fruit juice (fruit juice) is particularly preferable in order to enhance palatability. Preferred fruit juices can include apples, pears, lemons, limes, mandarines, grapefruits, cranberries, oranges, strawberries, grapes, kyui, pineapple, passion fruit, mango, guava, raspberries and cherries. Furthermore, it is also possible to contain natural flavors such as jasmine, chamomile, rose, peppermint, hawthorn, chrysanthemum, hilly, sugar cane, litchi, bamboo shoot and the like. The concentration of the fruit juice is not particularly limited, but for example 0.001 to 26% (w / v), preferably 0.01 to 18% (w / v), more preferably 0.04 to 12% ( w / v).

  Although it does not specifically limit as a sweetener, For example, fructose, glucose, sucrose, glucose fructose liquid sugar, fructose glucose liquid sugar, an oligosaccharide, etc. can be contained. The glucose content is, for example, 0.00001 to 22% (w / v), preferably 0.0001 to 18% (w / v), more preferably 0.001 to 12% (w / v). The fructose content is, for example, 0.00001 to 21% (w / v), preferably 0.0001 to 16% (w / v), and more preferably 0.001 to 12% (w / v). Each content of fructose glucose liquid sugar and glucose fructose liquid sugar is, for example, 0.001-8% (w / v), preferably 0.01-6% (w / v), more preferably 0.1-4. % (W / v). Examples of the oligosaccharide include sucrose, maltodextrin, corn syrup, high fructose corn syrup, agape extract, maple syrup, sugar cane, honey and the like. Among them, sucrose is preferable. Examples of sucrose forms include granulated sugar, liquid sugar, and white sugar. As sweeteners, aspartame, sucralose, saccharin, cyclamate, acesulfame-K, L-aspartyl-L-phenylalanine lower alkyl ester, L-aspartyl-D-alanine amide, L-aspartyl-D-serine amide, L Artificial sweeteners such as aspartyl-hydroxymethylalkanamide, L-aspartyl-1-hydroxyethylalkanamide, sucralose, etc. can also be included.

  In addition, as pharmacologically active ingredients, glycosaminoglycans such as dermatan sulfate, heparan sulfate, heparin, keratan sulfate, etc., Chinese herbal medicine (for example, Ogon Extract, Bakumon Fuyuto, Shiratora Kajinjinto, Gojosan, Hachimijiomaru, Semi-summer Kobaku-yu, Shion-yu, Sho-saiko-to, Juzen-taiho-yu, Inui, Ginger, Semi-summer, Tomochi, Akatsuki, Tenmon-fuyu, Gomi-ko, Kakkon, Ginseng, Murasaki-ne) Examples include analgesics, antibacterial agents, growth factors, adhesion factors, antibacterial agents and the like.

The viscosity of the xerostomia-improving beverage is not particularly limited and is set with appropriate consideration of ease of drinking by the elderly, persistence in the oral cavity, and the like. For example, the viscosity is measured at 25 ° C. at a shear rate of 1 second ⁻¹ . In this case, the value is preferably 1 to 9000 mPa · s, more preferably 5 to 4000 mPa · s, and particularly preferably 10 to 1400 mPa · s.

  The dry mouth improvement beverage is preferably a non-carbonated beverage in consideration of ease of drinking by the elderly, but can also be a carbonated beverage or a slightly carbonated beverage having moderate foaming properties with carbon dioxide gas. This makes it possible to give a refreshing feeling. Moreover, the dry mouth improving beverage can be a tea-based beverage or a non-tea-based beverage. As tea-based beverages, non-fermented tea beverages such as green tea beverages, semi-fermented tea beverages such as oolong tea beverages, and fermented tea beverages such as black tea beverages can be used.

  Moreover, the container-packed drink which concerns on this embodiment can also display the meaning of "improve xerostomia" on the outer peripheral surface of a container, when putting in a distribution process as goods, for example. Moreover, as long as the container-packed drink which concerns on this embodiment is what improves the symptom of xerostomia, any of a health drink, a quasi-drug, a 1st class pharmaceutical, a 2nd class pharmaceutical, or a 3rd class pharmaceutical Is also possible.

  In the above-described embodiment, the container-packed beverage according to the present embodiment is intended to improve the dry mouth of the elderly, but is not limited to such an embodiment, and the present embodiment. The packaged beverage according to the above can be widely applied to persons suffering from dry mouth disease. Moreover, the container-packed drink which concerns on this embodiment can be used even if it is any of temporary or continuous xerostomia. Temporary xerostomia occurs, for example, due to rapid dehydration, high fever, bleeding, stress, and the like. Persistent xerostomia is, for example, senile atrophy of the salivary gland, irradiation of the face or neck, salivary gland diseases such as Sjogren's syndrome, Mikulitz disease, chronic salivary glanditis, diabetes insipidus, diabetes, chronic renal failure, thyroid It occurs due to functional abnormalities, vitamin B group deficiency, anemia, administration of drugs (such as antihypertensives, diuretics, psychotropic drugs, neuroleptics, anticancer drugs, etc.), etc. The packaged beverage according to this embodiment has these symptoms Can be suitably suppressed.

  Using sodium hyaluronate as a moisturizing ingredient for dry mouth improvement beverages, (1) Feeling of use (when used), (2) Persistence (after use), (3) Effects other than dry mouth Each was subjected to a sensory test.

1% (w / v) sodium hyaluronate aqueous solution: (Purified sodium hyaluronate, (C ₁₄ H ₂₀ NaO ₁₁ ) n, average molecular weight 500-1.2 million) diluted with distilled water, 0.5% (w / v) The same aqueous solution of 0.25% (w / v), 0.1% (w / v), 0.05% (w / v), 0.01% (w / v), 0.005% (w / v) was used. After mixing, sufficient stirring was performed. The sensory test was a blinded randomized test based on a 0-10 scale evaluation with three dentists who had a good understanding of the disease of xerostomia.

First, (1) About the feeling of use (during use), a;
b; presence or absence of olfactory findings (* basically non-flavored and odorless, set for the purpose of detecting unpleasant symptoms), c; taste (* basically no additive and tasteless (except for salty taste with sodium salt), detection of unpleasant symptoms Objectives), d; Painful sensation (* Basically unstimulated, purpose of detecting unpleasant symptoms), and e; Comprehensive evaluation immediately after use (10 levels from "unpleasant" to "pleasant").

  Next, (2) For a feeling of persistence (after use), a: tactile sensation of the oral mucosa after use (moisture feeling (smoothness)), b: presence or absence of change in olfaction after use (0-10 rating) C: Presence or absence of change in taste after use (0-10 scale evaluation), d: Presence or absence of pain change after use (0-10 stage evaluation), e; Comprehensive evaluation after use (after 1 minute) (10 levels from “Sustained” to “No Persistence”), f; Comprehensive evaluation after use (10 minutes later) (10 levels from “Sustained” to “Sustained”), and g ; Tested for comprehensive evaluation after use (after 60 minutes) (10 levels from "sustained" to "not persistent").

  Next, (3) About effects other than dry mouth feeling, tests were conducted for a; presence / absence of throat discomfort (0-10 grade evaluation) and b; presence / absence of nasal mucosa discomfort (0-10 stage evaluation).

  The results of a blinded randomized trial conducted by three dentists who were well-understood about the disease of xerostomia were as shown in Tables 1 to 4 below. Table 1 shows the evaluation of the A inspector, Table 2 shows the evaluation of the B inspector, Table 3 shows the evaluation of the C inspector, and Table 4 shows the average value of the three inspectors.

  With 0.5% (w / v) sodium hyaluronate aqueous solution, (1) 10 feelings of use (when using) by a; oral mucosa touch (moisture feeling, smoothness) by all 3 examiners Results were obtained. Also, 0.25% (w / v) averages 9.0, 0.1% (w / v) averages 4.0, 0.05% (w / v) averages 2.0, 0.01% (w / v) averages 1.3, An average of 0 results was obtained at 0.005% (w / v).

  In addition, e: Comprehensive evaluation immediately after use In the 0-10 scale evaluation from "unpleasant" to "pleasant", 0.5% (w / v) is 3.0, 0.25% (w / v) is 6.0, 0.1% (w / v In v), 6.7, 0.05% (w / v) was 7.0, 0.01% (w / v) was 7.0, and 0.005% (w / v) was 7.0.

  On the other hand, as an unpleasant symptom, b; 0.5% (w / v) showed an average of 1.7 with or without olfactory findings. At 0.025% (w / v) or less, all examiners had zero. c: nasty taste, d;

  (2) About a feeling of persistence (after use), a; The sense of mouth mucous membrane after use (moisture feeling (smoothness)), on average, 0.5% (w / v) is 10.0, 0.25% (w / v ) Is 9.3, 0.1% (w / v) is 5.7, 0.05% (w / v) is 1.7, 0.01% (w / v) is 1.0 on average, 0.005% (w / v) is 0, 0.001% on average For (w / v), an average result of 1.0 was obtained.

  e; Overall evaluation after use (after 1 minute) is 0.5% (w / v), 0.25% (w / v), 0.1% (w / v) The w / v) was 5.0, 0.01% (w / v) was 3.0, and 0.005% (w / v) was 0.

  f; Overall evaluation after use (after 10 minutes) is 8.7 for 0.5% (w / v), 7.3 for 0.25% (w / v), 4.7 for 0.1% (w / v), 0.05% (w / v) In v), 1.7 and 0.01% (w / v) rated 1.7, and 0.005% (w / v) rated 1.0.

  g; Overall assessment after use (after 60 minutes) is 5.3 for 0.5% (w / v), 3.7 for 0.25% (w / v), 2.0 for 0.05% (w / v), 0.05% (w / v) In v), the evaluation was 0.3, 0.01% (w / v) was 0, and 0.005% (w / v) was 0.

  (3) Regarding effects other than dry mouth, a; presence or absence of pharyngeal discomfort is 2.3 for 0.5% (w / v), 0.3 for 0.25% (w / v), 0.1% (w / v), 0.05% ( The evaluation was 0 in w / v), 0.01% (w / v), and 0.005% (w / v).

  In addition, b: The presence or absence of nasal mucosal discomfort is 0.7, 0.25% (w / v), 0.1% (w / v), 0.05% (w / v), 0.01% (w / v) at 0.5% (w / v) v), 0.005% (w / v) was rated 0.

  The concentration of the hyaluronic acid sodium aqueous solution that is easily perceived as a moist or smooth touch of the oral mucosa is around 0.25% (w / v) (for example, 0.20 to 0.30% (w / v)), 0.1 When it was less than% (w / v), there was a possibility that some users might not be aware. Also, in the results after use, it was considered that it was difficult to recognize when the moisture feeling and smoothness were less than 0.1% (w / v). On the other hand, as an unpleasant symptom, this time, 0.5% (w / v) obtained a result of slightly feeling a strange taste. In addition, at 0.5% (w / v), pharyngeal discomfort and nasal mucosal discomfort were slightly recognized. From the results, unpleasant symptoms are only slightly noticeable, there is no limit on the amount of sodium hyaluronate and there is no particular restriction on the intake, but in order to improve the feeling of use for the elderly, It is thought that it is better to set a certain threshold value for the concentration, and when sodium hyaluronate is used as a moisturizing component of a dry mouth improvement beverage, 0.20 to 0.30% (w / v) is preferable, especially 0.25 % (W / v) had almost no discomfort and was able to recognize the moist feeling and smoothness of the oral mucosa.

  The present invention can be used to treat xerostomia in elderly people.

Claims (8)

A beverage containing 0.250 % (w / v) aqueous sodium hyaluronate, an antibacterial agent, and lactoferrin is filled in a PET bottle container.
The sodium hyaluronate has a weight average molecular weight of 1.2 million;
A plastic bottle-packed beverage to improve dry mouth in the elderly. The beverage is at least any one of collagen, polyglutamic acid or a pharmaceutically acceptable salt thereof, poly-γ-glutamic acid or a pharmaceutically acceptable salt thereof, propylene glycol, hydrolyzed hydrogenated starch, and milk protein extract. The container-packed drink according to claim 1 , further comprising a moisturizing ingredient including any one of them. The beverage contains a salivary secretion-promoting component having an organic acid containing at least one of citric acid, malic acid, tartaric acid, fumaric acid and succinic acid, or a pharmaceutically acceptable salt thereof. The container-packed drink of Claim 1 or 2 to do. The said drink contains the saliva component which contains at least any one among sodium chloride, potassium chloride, calcium chloride, magnesium chloride, and dipotassium phosphate, The any one of Claim 1 thru | or 3 characterized by the above-mentioned. The container-packed drink of description. The beverage comprises lysozyme, lysozyme chloride, histatin, peroxidase, sialoperoxidase, myeloperoxidase, agglutinin, defensin, lactoperoxidase, glucose oxidase, potassium thiocyanate, beta D glucose, and immunoglobulin. The container-packed drink according to any one of claims 1 to 4 , further comprising a cleaning auxiliary component. The beverage contains at least one of sugar alcohols such as xylitol, erythritol, sorbitol, mannitol, reduced lactose, reduced maltose starch syrup, reduced starch syrup, propylene glycol, 1,3-butylene glycol, polyethylene glycol, and glycerin. The container-packed drink according to any one of claims 1 to 5 , comprising a polyhydric alcohol. The said drink contains the water-soluble polymeric substance containing at least any one among sodium carboxymethylcellulose, polyvinylpyrrolidone, xanthan gum, carrageenan, and sodium alginate, The any one of Claim 1 thru | or 6 characterized by the above-mentioned. The container-packed drink of description. The beverage is glucosamine, chondroitin, lutein, folic acid, fatty acid, fruit extract, vegetable extract, vitamin, mineral, phosphatidylserine, lipoic acid, melatonin, Aloe Vera, Guggul, amino acid, lycopene , herbs, catechins, caffeine, flavonoids constituents of fruits, evening primrose oil, and any one of claims 1 to 7, characterized in that it contains a nutraceutical component comprising at least any one of the linseed oil 1 The container-packed drink of description.