JP6424355B2 - Skin external preparation kit - Google Patents

Description

  The present invention is a kit for obtaining an effervescent skin external preparation, wherein the first agent is a composition containing an acidic substance and a thickener, and the second agent reacts with the acidic substance to produce carbon dioxide gas. The present invention relates to a kit characterized in that it is a composition containing a carbon dioxide gas-generating substance that generates water, water and / or a humectant.

Since carbon dioxide acts on the skin to promote blood circulation, skin external preparations using various carbon dioxides have been proposed. Most of these generate carbon dioxide gas by the reaction of an acidic substance and a carbon dioxide gas generating substance. For example, in order to maintain the effect of generated carbon dioxide, a method of using a water-containing viscous composition containing an acidic substance, water and a thickener, and a solid carbon dioxide gas-generating substance mixed immediately before use is proposed. (Patent Document 1). In addition, it is mixed with water immediately before use to a particulate material that is hydrolyzed to form an acid, a carbonate, a thickener, a gelling agent that gels with calcium ions, and a water insoluble or poorly water soluble calcium salt. The method to use is proposed (patent document 2)

WO 99/24043 WO 2006/80398

  However, when carbon dioxide gas is generated by the method described in Patent Document 1, uniform mixing of the water-containing viscous composition and the solid carbon dioxide gas-generating substance is difficult, and unevenness is easily generated in foaming by carbon dioxide gas. Takes a long time to start. Further, in the method described in Patent Document 2, since it takes time to measure water, it is troublesome for the user, and the viscosity and carbon dioxide gas generation amount at the time of use are not constant due to the quality of water used. , The effect will be different for each use.

  The present invention has been made in view of the above circumstances, and it is an object of the present invention to provide a kit for obtaining an effervescent skin external preparation of a certain quality, which is easily mixed uniformly during mixing and carbon dioxide gas is generated uniformly.

The present invention provides a kit for obtaining the following foamable skin external preparation (hereinafter also referred to as the kit of the present invention).
It is a kit for obtaining <1> foamable skin external preparation, Comprising: A 1st agent is a composition containing an acidic substance and a thickener, A 2nd agent reacts with the said acidic substance, and it is a carbon dioxide gas A kit comprising the generated carbon dioxide gas generating substance, water and / or a moisturizing agent.
<2> The kit according to <1>, wherein the first agent is a solid composition.
The kit according to <1> or <2>, wherein the <3> second agent is a liquid composition.
<4> The kit according to any one of <1> to <3>, wherein the second agent contains a carbon dioxide gas-generating substance that reacts with the acidic substance to generate carbon dioxide gas, water, and a humectant. .
The kit according to any one of <1> to <4>, wherein the viscosity of the <5> second agent is 50,000 mPa · s or less.
The <6> first agent and the second agent are mixed at a weight ratio in the range of 1: 0.1 to 1:30, and used, wherein it is used according to any one of <1> to <5>. kit.

  ADVANTAGE OF THE INVENTION According to this invention, a user can mix easily uniformly at the time of mixing, a carbon dioxide gas can be generated immediately uniformly, and the kit for obtaining the foamable skin external preparation of a fixed quality can be provided. In addition, by blending an acidic substance in the first agent and blending a carbon dioxide gas generating substance in the second agent, it is possible to keep the quality stable. In particular, it is not necessary to blend a storage stabilizer or an antioxidant to prevent the deterioration of the quality, or to limit the storage container to a specific one, thereby enabling low-cost manufacturing. Furthermore, by using the foamable skin external preparation obtained by using the kit of the present invention as a pack agent, it is possible to obtain a skin condition improving effect, in particular, a whitening effect in a short time.

The increase rate of the volume by the carbon dioxide of the foamable skin external preparation obtained using the kit of this invention is shown.

  The present invention is a kit for obtaining an effervescent skin external preparation, wherein the first agent is a composition containing an acidic substance and a thickener, and the second agent reacts with the acidic substance to produce carbon dioxide gas. And a water and / or a moisturizing agent.

  Then, in the kit of the present invention, the user appropriately mixes the first agent and the second agent at the time of use to cause foaming due to carbon dioxide gas generation, which can be applied to the skin and used. The kit of the present invention is characterized by having good storage stability by being divided into the first agent and the second agent, and being easy for the user to handle at the time of use. Hereinafter, each component contained in the effervescent skin external preparation obtained by using the kit of the present invention and the kit of the present invention and the production method thereof will be described.

<First agent>
The first agent in the kit of the present invention (hereinafter also referred to as the first agent) contains an acidic substance and a thickener. The first agent is preferably a solid composition, and more preferably in the form of granules, fine particles, or powder from the viewpoint of ease of mixing with the second agent.

«Acidic substance»
As an acidic substance used for the first agent of the present invention, any of an organic acid and an inorganic acid may be used, and one or more of these may be used. Moreover, the acidic substance to be used is preferably solid, and it is easy to mix with other components contained in the first agent, and easy to mix when mixing with the second agent. Powder is more preferable.

  As organic acids, linear fatty acids or salts thereof such as formic acid, acetic acid, propionic acid, butyric acid and valeric acid, oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, fumaric acid, maleic acid and phthalic acid Acid, isophthalic acid, dicarboxylic acid such as terephthalic acid or a salt thereof, acidic amino acid or a salt thereof such as glutamic acid or aspartic acid, glycolic acid, malic acid, tartaric acid, citric acid, lactic acid, hydroxyacrylic acid, α-oxybutyric acid, glycerin Acids, tartronic acid, salicylic acid, gallic acid, tropic acid, ascorbic acid, gluconic acid and other oxy acids or salts thereof, and the like, and inorganic acids include inorganic acids such as phosphoric acid and sulfite, or salts thereof, One or two or more of these can be used. Among them, citric acid or a salt thereof, ascorbic acid or a salt thereof, malic acid or a salt thereof, succinic acid or a salt thereof is preferable from the viewpoint of safety and solubility in a second agent, citric acid or a salt thereof An acid or a salt thereof is more preferred.

  The said acidic substance can be used by 1st agent as a mixture with other components. Here, when the granules of the acidic substance are obtained by granulating the acidic substance and the other components, the content of the other components is not particularly limited, but it is less than 95% by mass in the granules. Is preferred. If the other components are present in a content of more than 95% by mass, the foamability is unfavorably lowered.

  The method for producing the above powder or granules is not limited to the present example, and methods such as dry crushing granulation method, wet crushing granulation method, fluidized bed granulation method, high speed stirring granulation method, extrusion granulation method, etc. It can be manufactured according to a conventional method.

  For example, in the production of granules, a matrix substrate having a function such as molding of granules may be used. When a low melting point compound is used as a matrix base, the acidic substance is added to the low melting point compound melted by heating in a container such as a beaker and sufficiently stirred and mixed. If necessary, suitable additives may be added thereto. The mixture is further stirred while being gradually cooled at room temperature and left to solidify. If it has solidified to a certain extent, it may be cooled rapidly by a refrigerator or the like.

  Alternatively, for example, the material may be charged into a fluid bed granulator, mixed for several minutes by air flow, and granulated by spraying water thereon.

  When a low melting point compound is not used as the matrix base, the granulating agent is dissolved or dispersed in a suitable solvent such as water or ethanol in a container such as a beaker, and the carbon dioxide gas generating substance is dissolved or dispersed therein. After thorough mixing, the mixture is heated in an oven or the like to remove the solvent and dried. When it is completely solidified, it is crushed and sieved to make the particle size uniform, and then made into granules.

  As the shape of the acidic substance, for example, irregular shapes, flat shapes, polyhedral shapes, spheres, drops, fibers, cylinders, fine powders, etc. can be adopted without particular limitation. Moreover, as the particle size, the thing of a wide range can be especially used without a restriction | limiting. In particular, those having a particle size distribution of about 1,000 μm or less are more preferable in terms of ease of handling and ease of mixing with the viscous composition. The above particle size distribution in the present invention can be determined by a conventional laser diffraction / scattering method.

  The acidic substance may be blended as it is with the component contained in the first agent, but may be blended so as not to be in physical contact with other components in the same agent. In this case, for example, a coat layer may be provided on one or both of the acidic substance and the other component, or the acid substance and the other component may be encapsulated. Good. In addition, a layer not containing the acidic substance and other components may be sandwiched between the acidic substance and the component so as not to be in direct contact with each other, and compression molding may be performed.

  The means for coexistence of the acidic substance and the other components in the same agent will be specifically described below, but the invention is not limited thereto.

[Coat layer formation]
As a method for forming a coat layer, for example, a method of forming a coat layer on at least one of an acidic substance or another component may be used. By providing a coating layer, it is preferable in terms of stability and durability of the acid substance, the other components and the other components in the same agent.

  As a preferable coating agent for comprising the said coating layer, if it is a thing with low reactivity with the said acidic substance or said other component, it can use, without specifically limiting. For example, fats and oils, fatty acids, fatty acid salts, acetylcellulose, hydroxyethylcellulose, carboxymethylcellulose sodium, polyvinylpyrrolidone, polyvinyl alcohol, sodium polyacrylate, hydroxypropyl methylcellulose, methyl methacrylate-methacrylic acid copolymer, ethyl acrylate-methacrylic acid Copolymers, gum arabic, sodium alginate, soluble starch, hydroxypropyl cellulose, wheat starch, polysaccharides (eg sucrose, lactose etc.), citrate etc. may be mentioned. In particular, when an acidic substance such as citric acid is coated, it is preferable to use a citrate such as calcium citrate. Alternatively, the coating layer may be formed using a solid hydrocarbon wax, a solid fat and the like, and the like which are melted at a certain temperature or more by heating.

  The amount of coating agent used for the acidic substance and / or the other components is preferably about 1 to 20% (w / w), more preferably about 1 to 10% (w / w) based on the acidic substance or the other components. Be done.

  The coating method of the coating layer may be carried out by any method as long as it is commonly used to coat particles. For example, it may be coated simultaneously with granulation by spray granulation, rolling granulation, etc., oil coating, granulation coating, transport layer method, pan coating, rolling coating, fluidized coating or powder or granules It may be coated using a method such as dry coating. During coating, if excessive heat or physical force is applied, the acid substance or the other component is destroyed, and the formed film is broken, and the lipid on the entire surface of the acid substance or the other component Not only is it difficult to uniformly coat the powder, but also the acid substance or the other component leaks to the surface and causes solidification due to moisture absorption or causes adverse effects on other components at the time of compounding, so the coating conditions are coating layers And it is necessary to make it the thing which coating object is not destroyed.

[Encapsulation]
When encapsulating the acidic substance and / or the other components, known methods may be adopted without particular limitation.

  As a method of encapsulation, known methods can be applied without particular limitation, and as a material of encapsulation, gelatin, starch, gum arabic, methyl cellulose, acrylic ester, methacrylic ester, vinyl acetate, Although polyvinyl alcohol, silicone resin, solid wax, polyethylene, fatty acid, higher alcohol, etc., and those in which multiple layers of surfactant such as liposome are formed are included, they can be widely used without limitation. For example, the basic structure of the capsule consists of a homopolymer or copolymer formed from one or more monomers selected from acrylic ester, methacrylic ester, vinyl acetate, styrene, or acrylic acid, methacrylic acid, divinyl with said monomer It is also preferable to use a resin capsule made of a copolymer formed from a monomer selected from benzene and ethylene glycol dimethacrylate. Such microcapsules are prepared by emulsifying the content and the constituent monomers of the polymer constituting the shell of the capsule in a reaction solvent such as water, and initiating polymerization of azobisisobutyronitrile, benzoyl peroxide, etc. An agent may be added to carry out emulsion polymerization. As a surfactant component used for this emulsification, for example, Hexlight sold under the name of "Laponite XLG" can be suitably exemplified. The microcapsules of the present invention can be produced by separating the resulting microcapsules by means such as centrifugation and optionally washing.

[Compression molding]
As a method of compression molding, a substance other than the acid substance and the other component (for example, shaping) so that they do not directly contact between the first layer containing the acid substance and the second layer containing the other component And the third layer comprising an agent, a thickener, etc.) may be sandwiched and compression molded. The compression-molded dosage form may be any solid dosage form such as tablet, sphere, plate and the like. Here, the above-mentioned acidic substance and the above-mentioned other components may be used as they are, or the above-mentioned acidic substance or the above-mentioned other components in which the coating layer is provided by any of the above methods on either one or more of the first and second layers. Alternatively, the encapsulated acidic substance or the other component may be used. The method of compression molding can apply a well-known method, without being limited in particular.

  The acidic substance and the other components contained in the first layer and the second layer may be used as they are, or may be mixed with an excipient, a thickener or the like in addition thereto. As the excipients, thickeners and the like used in the first layer, the second layer and the third layer, those described in the above description of the granules can be used without particular limitation.

  The acidic substance is preferably contained in the first agent in an amount of 1 to 50% by mass, more preferably 3 to 40% by mass, and still more preferably 5 to 30% by mass. If the above range is exceeded, the stability of the first agent will deteriorate, and the foamability at the time of use will deteriorate, or the pH at the time of using as an effervescent skin external preparation will become strongly acidic or strongly basic, Stimulation of the skin may become intense.

«Thickener»
The thickener used in the first agent of the present invention is not particularly limited as long as it is a water-soluble component that can be used in cosmetics, external medicines, quasi drugs, etc. Synthetic polymers, semi-synthetic high Molecules, natural polymers, viscous minerals, etc. can be used.

As synthetic polymers, carboxyvinyl polymer, polyvinyl alcohol, acrylic acid / methacrylic acid alkyl copolymer, acrylate / alkyl acrylic crosspolymer, polyacrylic acid, polyacrylamide, polyalkylacrylamide / polyacrylamide copolymer, carboxymethylcellulose, cation And hydrophilic synthetic polymers including pluronics.

As semi-synthetic polymers, examples of cellulose derivatives include carboxymethyl cellulose or salts thereof, methyl cellulose, ethyl cellulose, propyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, sulfonated cellulose derivatives and the like. Other semi-synthetic polymers include alginic acid propylene glycol ester, alginic acid ethylene glycol ester, dextrin fatty acid ester, gelatin fatty acid ester, gelatin fatty acid amide and the like.

Natural polymers include polysaccharides and derivatives thereof such as xanthan gum, succinoglycan, carrageenan, guar gum, locust bean gum, celluloses, galactan, gum arabic, tragacanth gum, tamarind gum, agar, agarose, mannan, curdlan, Alginic acid or salts thereof, gum arabic, pectin, quinseed, starch, alge colloid, chondroitin sulfate or salts thereof, chitosan and derivatives thereof, and the like can be mentioned. Other natural polymers include nucleic acids or salts thereof, ribonucleic acid or salts thereof, casein, collagen, gelatin, albumin, fibroin, elastin, keratin, water-soluble proteins such as keratin, sericin, hyaluronic acid or salts thereof, chondroitin sulfate, etc. Muco polysaccharide etc. are mentioned.

Examples of clay minerals include laponite, bentonite, smectite kaolinite, montmorillonite and the like.

  Among the above thickeners, using one having high solubility or dispersibility in the second agent can uniformly dissolve or disperse the first agent without causing lumps, and undissolved component or undispersed It is preferable because it can alleviate the texture of the skin caused by the ingredients. Here, whether or not the solubility in the second agent is good or bad is that, when the second agent at about room temperature is added and stirred, the external skin preparation instantaneously dissolves or disperses in water or a moisturizing agent and dissolves uniformly. It can be judged from having sufficient viscosity to hold carbon dioxide gas, and not producing lumps at the time of dissolution or dispersion.

  As such a thickener, for example, carboxyvinyl polymer, carboxymethylcellulose or salts thereof, polyvinyl alcohol, sodium polyacrylate, alkyl acrylate / methacrylate copolymer, xanthan gum, succinoglycan, carrageenan, guar gum, locust Bean gum, cellulose, galactan, gum arabic gum, tragant gum, tamarind gum, agar, mannan, curdlan, alginic acid or salts thereof, collagen, gelatin, albumin, etc. may be mentioned, carboxymethylcellulose or salts thereof, xanthan gum, carrageenan, It is preferred to use albumin. The said thickener can use 1 type, or 2 or more types. When two or more types are used, it is preferable to use a water-soluble protein from the viewpoint of retention of generated carbon dioxide gas and foam quality by carbon dioxide gas, and a combination of water-soluble protein and other thickeners may be used More preferable. As the water soluble protein, collagen, gelatin and albumin are preferred.

  The thickener is preferably contained in the first agent in an amount of 1 to 50% by mass, more preferably 3 to 45% by mass, and still more preferably 5 to 40% by mass. If the content is too small, a feeling of graininess due to the undissolved component and the undispersed component tends to occur when mixing the first agent and the second agent, and the feeling of use is impaired. In addition to being prone to dripping during use and lacking in adhesion to the skin, the ability to retain generated carbon dioxide is also poor, so it is not possible to obtain a sufficient blood circulation promoting action. On the other hand, if the content of the thickener exceeds the above range, the solubility and dispersibility in the second agent are poor, and a lump is generated to cause discomfort upon application to the skin, or the viscosity is too high. It will be difficult to apply to the skin and it will be difficult to wash away. In addition, since the generation of carbon dioxide gas is uneven and the retention capacity of the generated carbon dioxide gas is not very high, it is impossible to obtain a sufficient blood circulation promoting effect.

  The first agent can use an excipient as needed. The excipient which can be used is an excipient which can be used in cosmetics, external medicines, quasi-drugs and the like. Specific examples thereof include, for example, glucose, maltitol, lactose, dextrin, starch, talc, silica and the like, with preference given to glucose, dextrin and starch.

<Second agent>
The second agent in the kit of the present invention contains a carbon dioxide gas-generating substance that reacts with an acidic substance to generate carbon dioxide gas, water and / or a humectant. Preferably, it contains a carbon dioxide gas generating substance, water and a humectant.

«Carbon dioxide gas generating substance»
Various substances can be used without particular limitation as the carbon dioxide gas generating material used for the second agent of the present invention. The carbon dioxide gas generating material to be used is preferably solid, and more preferably granular, fine granular or powdery from the viewpoint of solubility in water or a moisturizer.

  As the carbon dioxide gas generating material, carbonates such as sodium carbonate, calcium carbonate, potassium carbonate, magnesium carbonate, sodium sesquicarbonate, ammonium hydrogencarbonate, potassium hydrogencarbonate, sodium hydrogencarbonate, lithium hydrogencarbonate, lithium hydrogencarbonate, cesium hydrogencarbonate, magnesium hydrogencarbonate And hydrogen carbonates such as calcium hydrogen carbonate, and the like, and one or more of these may be used. Among these, sodium hydrogencarbonate is more preferable in that a hydrogen carbonate can be preferably used and a moderate foaming power can be realized.

  0.05-30 mass% is preferable in a 2nd agent, 0.1-25 mass% is more preferable, and, as for the said carbon dioxide gas-generating substance, 0.5-20 mass% is still more preferable.

«Water»
Water usable as the second agent may be water usable in cosmetics, external medicines, quasi drugs, etc., but purified water, distilled water, membrane-filtered water, ion-exchanged water is preferred. The compounding amount may be 1% by mass or more in the second agent, preferably 3 to 95% by mass, and more preferably 5 to 90% by mass. If the content is less than 1% by mass, problems such as the carbon dioxide gas being hard to be generated when the first agent and the second agent are mixed, the reduction of the carbon dioxide gas generation amount, etc. arise. , You can not get enough blood circulation promoting effect.

«Moisturizer»
As a moisturizing agent used for the second agent, it is used in general cosmetics, external medicines, quasi-drugs, etc. as polyhydric alcohols, saccharides, amino acids, organic acids, sterols, urea, proteins, plant extracts and the like A moisturizer that can be used can be used. As specific examples, for example, polyglycerin such as glycerin, diglycerin, triglycerin, tetraglycerin, ethylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, propylene glycol, dipropylene glycol, polyethylene glycol, 1, Polyhydric alcohols such as 3-propanediol, sorbitol, polyglycerin derivative, polyoxyalkylene alkyl glucoside, sodium lactate, sodium pyrrolidonecarboxylate, almond, avocado, altea, aloe, usvenia oasis, nononis, oats, licorice, quince seed, Clara (Kujin), Gardenia, Grapefruit, Watercress, Gentiana, Genno Shoko, Burdock, Wheat, Saishin, Cactus, Soapwort, Hawthorn, Geow, Mozuku, ginger, zinnia oats, mulberry, satin indigo asparagus, caterpillar herbaceous, dokdami, peppermint, crowhead, hamamelis, rose, cypress, daisies, daisies, prunes, prairie, bodice, hops, pine, quince, marronio, melissa, melissa, cornflower, lily And plant extracts such as lavender, apple, rice and rice bran, blackcurrant, ibuquitoranoo, neubara, eleostoke, seaweed etc., and one or more of them can be used. Among the above-mentioned humectants, at least one polyhydric alcohol is preferably used from the viewpoint of storage stability of the second agent, production cost, and alleviation of irritation to the skin at the time of use. It is preferable to use at least one of 3-butylene glycol, 1,4-butylene glycol, dipropylene glycol and polyethylene glycol. When a moisturizing agent is used, the amount thereof is slightly different depending on the kind of moisturizing agent, but it may be 0.01% by mass or more, preferably 0.01 to 95% by mass, and 0.5 to 90 % By mass is more preferable, and 1 to 80% by mass is even more preferable. When the content is less than 0.01% by mass, not only the effects to the skin such as the amount of diffused water and elasticity decrease but also the ease of handling at the time of use, such as ease of mixing and coating, dripping resistance, Ease of removal becomes worse. Further, if it is more than 90% by mass, problems such as the carbon dioxide gas being hard to be generated when the first agent and the second agent are mixed, the reduction of the carbon dioxide gas generation amount, etc. arise, and as a result, sufficient Can not obtain a good blood circulation promoting effect.

The second agent of the present invention contains water and / or a humectant together with a carbon dioxide gas generating substance, but preferably contains water and a humectant. By containing water and a moisturizing agent, the foaming time can be properly maintained, and as is apparent from Examples 2 to 4 described later, the moisture content and elasticity of the stratum corneum, the moist feeling of the skin, the skin such as brightness and redness Not only the improvement of the condition, but also the ease of use, ease of application, ease of use such as drip resistance is improved.

The second agent of the present invention is preferably a liquid composition, and in view of miscibility with the first agent, the viscosity is more preferably low. Specifically, the viscosity at 25 ° C. is preferably 50,000 mPa · s or less, more preferably 30,000 mPa · s or less, particularly preferably 10,000 mPa · s or less, still more preferably 5,000 mPa · s.・ S less than or equal to Moreover, it is preferable that the 2nd agent of this invention does not contain a thickener substantially. Here, "substantially free of a thickener" means that the thickener used in the first agent of the present invention is not contained in the second agent. In the present invention, when the viscosity of the second agent exceeds 50,000 mPa · s, it becomes difficult to uniformly disperse the first agent in the second agent which is a viscous composition when mixed with the first agent, and foaming by carbon dioxide gas Unevenness is likely to occur. In addition, it takes time to start foaming. Using a liquid composition having a low viscosity for the second agent, as is apparent from Example 5 described later, can brighten the skin and maintain its brightness, as well as the skin condition such as moistness and elasticity of the skin. While having the effect of improving, since the usability | use_conditions, such as the ease of mixing at the time of use and ease of application, improves, it is preferable.

Further, as a two-part kit for obtaining an effervescent skin external preparation, a powder containing a carbon dioxide gas generating substance in a first agent and a liquid containing an acidic substance and water in a second agent can also be considered. However, when an acidic substance is used as the second agent, for example, the acidic substance itself is decomposed, or the compounding component is decomposed by the acid substance, or the acid material acts as a catalyst to cause reaction between the compounding components. Changes in viscosity and pH are likely to occur, making long-term storage difficult. In addition, if only the second agent is mistakenly applied to the skin, there is a safety problem such as giving strong irritation to the skin. On the other hand, when a carbon dioxide gas generating substance is used as in the second agent of the present invention, there is no risk of decomposition of the carbon dioxide gas generating substance or other compounding components or reaction of the compounding components, so the stability is excellent. In addition, even if only the second agent is accidentally used, there is little skin irritation. Furthermore, as is clear from Example 2 described later, the second agent of the present invention uses the carbon dioxide gas-generating substance, and the mixing ease at the time of use, as compared with the case of using the acidic substance for the second agent, While improving the feeling of use such as easiness of application, sagging and ease of removal, it is also preferable because it has skin condition improving effects such as moist feeling, elasticity, brightness and redness of the skin.

<Skin external preparation>
The effervescent skin external preparation produced by using the kit of the present invention has other active ingredients, preservatives, pH adjusters, oils and fats in addition to the components contained in the first and second agents according to the application and purpose. , Perfumes, coloring agents, antioxidants, antifungal agents, alcohols, nonionic surfactants, anionic surfactants, cationic surfactants, surfactants such as amphoteric surfactants, inorganic salts, lubricants It is possible to use one or more components usually used for external skin preparations such as solvents and the like. In this case, the components to be added can be used for either the first agent or the second agent, or may be used for either agent.

  Hereinafter, representative ones of components other than the acidic substance, the carbon dioxide gas generating substance, the thickener, and the moisturizing agent, which are contained in the foamable skin external preparation produced using the kit of the present invention, will be further described.

  The active ingredient used in the present invention is not particularly limited, and drugs, plants and the like used for cosmetics, external medicines, quasi-drugs and the like can be used according to the purpose. Typically, for example, glycyrrhizinic acid and derivatives thereof and salts thereof, glycyrrhetinic acid and derivatives thereof and salts thereof, mefenamic acid, phenylbutazone, indomethacin, ibuprofen, ketoprofen, allantoin, guaiazulene, panthenol, Anti-inflammatory agents such as allantoin, ascorbic acid and its derivatives and salts thereof, cysteine and its derivatives, glabridin, glabrene, liquiritin, isoliquiritin, placenta, hydroquinone and its derivatives, resorcin and its derivatives, whitening agents such as glutathione , Sulfur, antiseborrhoic agents such as thianthrol, bactericidal agents such as salicylic acid, oat extract, tocopherol and its derivatives, botanical ingredients such as licorice, aloe, tea leaves, estradiol Hormones, etc. and the like. In addition, when using a plant ingredient, the whole grass, leaf (leaf, petiole etc.), fruit (mature, immature etc.), seed, flower (petal, ovary etc.), stem, rhizome, root, tuberous root etc. These can be used as they are as they are, cut, crushed, crushed, squeezed, extracted, or dried or powdered of those treated. The active ingredient used in the present invention can be used in any of the first agent and the second agent.

  When an extract is used in the present invention, as a solvent used for extraction, for example, water; methanol, ethanol, propanol, butanol, ethylene glycol, propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, hexylene glycol And organic solvents such as glycerin, methyl acetate, ethyl acetate, isopropyl acetate, ethyl ether and acetone. These can be used alone or in combination of two or more. From the viewpoint of safety etc., it is preferable to use water, ethanol, 1,3-butylene glycol or a mixed solvent thereof harmless to the human body as the extraction solvent. The extraction may be performed at a temperature equal to or lower than the boiling point of the extraction solvent, and the extraction time can be appropriately changed depending on the extraction temperature. When the extract is used in the first agent of the present invention, the extract may include water used as an extraction solvent, but when it is used as a component of the first agent, it is substantially free of water preferable. Here, "substantially free of water" means that it does not contain the amount of water necessary to degrade the quality during storage of the first agent.

  Surfactants used in the present invention include nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants. As the surfactant, any of synthetic surfactants and natural surfactants can be used, but natural surfactants are preferable from the viewpoint of safety to the skin. The term "natural surfactant" as used herein refers to substances having surfactant effects mainly from animal or plant origin, and specific examples include phospholipids such as lecithin, glycolipids, lanolin, cholesterol, saponin, ceramide And sphingolipids, pectin, glycyrrhizinate, bile acid, plant-extracted amino acid surfactant and the like. Among them, it is preferable to contain an extract containing phospholipid, saponin, sphingolipid, pectin and glycyrrhizinate, and it is particularly preferable to contain an extract containing saponin. As an extract containing saponin, it is preferable to use a plant-derived extract. Examples of plants containing saponin include soybeans, azuki beans, green beans, spinach, sugar beets, grapes, persimmons, licorice, licorice, Senega, quillaja, mukuroji, soapworts, ginsengs, ginseng, tea seeds, apricots and liliaceae plants Plants, chimo (chimo), bakumondo (mochimon winter) etc. can be mentioned. In the present invention, as an extract containing saponin, among these plants, it is preferable to contain an extract of one or more kinds of plants selected from soybean, azuki bean, licorice, mukurodi and hetima, and particularly an extract of muclodi It is preferable to contain

  The said natural surfactant can keep air bubbles longer by using it together with a thickener. The thickeners that can be used in combination are the same as those used for the first agent.

<Use form of effervescent skin external preparation>
The kit of the present invention causes foaming by carbon dioxide gas by mixing the first agent and the second agent in an appropriate amount container when used for obtaining the effervescent skin external preparation. The first agent and the second agent are preferably mixed in a ratio of 1: 0.1 to 1:30, more preferably in a ratio of 1: 0.5 to 1:10, 1: 1 to 1 It is particularly preferable to mix in a ratio of 5 :.

  As a method of storing the kit of the present invention, a method of storing cosmetics, external medicines, quasi-drugs and the like can be used. There is no particular limitation, but the first agent is stored in a state of blocking water and not contacting It is good to be done. The shape of the storage container to be used can be suitably selected according to the purpose, and cup shape, tube shape, bag shape, bottle shape, stick shape, pump shape, jar shape, canned shape etc. are mentioned. Moreover, although the material which comprises a storage container can select and use plastic, glass, aluminum, paper, various polymers etc. individually or 2 types or more, for example, it is not limited to these.

  Specific examples of the container include an aluminum stick laminated on the inner surface with polyethylene terephthalate, a storage container such as an aluminum bag, a stand pouch with a chuck, and an inner surface polyethylene terephthalate in terms of sealing property, storage stability of contents, manufacturing cost, etc. A storage container made of polyethylene terephthalate whose lid is heat-sealed with an aluminum film laminated in the above is preferable.

<Application of effervescent skin external preparation>
The effervescent skin external preparation obtained by using the kit of the present invention promotes skin blood flow, and provides whitening, skin quality improvement, freckle improvement, skin rejuvenation, skin firmness, partial thinning, skin Cleanse, condition skin, condition skin texture, keep skin healthy, prevent skin roughening, make skin firm, have moisture on skin, keep skin moisture and oil, keep skin flexible, Protects the skin, prevents dryness on the skin, softens the skin, imparts firmness to the skin, provides gloss on the skin, smoothes the skin, prevents stains and drippings caused by the sun, highlights small wrinkles caused by the dryness As well as cosmetic products intended to eliminate, it is the skin, that kind of thing, that kind of heat, the heat, the heat, the crack, the crack, the aggravation, the acne prevention, the oiled skin, the prevention of the razor burn, the prevention of the stain and the freckle due to the sun, the sun・ Snowy Cosmetics / Pharmaceuticals for the purpose of preventing hot flashes, cleansing the skin, conditioning the skin, keeping the skin healthy, giving moisture to the skin, protecting the skin, preventing dryness of the skin, etc. It can be suitably used for any of non-prescription products and medicines such as medicines. The external preparation for skin of the present invention is preferably used as cosmetics and quasi-drugs, and more preferably used as cosmetics and cosmeceutical products such as emulsions, creams, packs and peeling agents. Among them, when used as a pack agent, it is preferable because the feeling of use is good and the high skin condition improving effect can be easily obtained in a short time.

  When the foamable skin external preparation obtained by using the kit of the present invention is used as a pack, it may be applied to a thickness of 0.2 mm or more, preferably 0.5 mm or more so as to cover a desired site. By applying to a thickness of 0.2 mm or more, the skin condition improving effect by carbon dioxide gas can be obtained. The use time may be 1 minute or more, preferably 3 minutes or more, and more preferably 5 minutes or more. After the application is completed, it may be wiped off, washed with water or the like, or both.

  EXAMPLES The present invention will be more specifically described below with reference to examples, but the scope of the present invention is not limited to these examples. In the following examples and comparative examples, the raw materials used were commercial products unless otherwise specified.

<Production of effervescent skin external preparation>
According to the composition shown in Table 1, a kit of the present invention was manufactured.

Examples 1 to 4, Comparative Example 1
[First agent]
The raw materials described in the first agent were mixed to obtain a powdery first agent.
[Second agent]
Purified water was added to a beaker, and then the raw material described in the second agent was added and stirred to obtain a liquid second agent.
Comparative example 2
[First agent]
The raw materials described in the first agent were mixed to obtain a powdery first agent.
[Second agent]
Purified water was placed in a beaker, then a thickener was added and stirred to obtain a second agent of a viscous composition.

<Characteristics evaluation of effervescent skin external preparation>
According to the following procedure, the properties of the foamable skin external preparation obtained in Examples 1 to 3 and Comparative Examples 1 to 3 were evaluated.
Evaluation Example 1 Evaluation of Second Agent Viscosity]
In the second agent described in Table 1, the viscosities of Examples 1 to 4 and Comparative Examples 1 to 2 were measured using a viscometer (RVT type manufactured by Brookfield Co., Ltd.). The results are shown in Table 2.

Evaluation Example 2 Evaluation of foaming amount]
Examples 1 to 4, Comparative Example 1
In a bottle having a diameter of about 4.8 cm and a height of about 10.5 cm, 27 g of the second agent was placed, to which 9 g of the first agent was added, and stirred 20 times for 10 seconds. The volumes after 1 minute, 10 minutes and 20 minutes were measured, and the rate of increase in volume relative to the volume before stirring was measured. The results are shown in FIG.

Comparative example 2
In a bottle having a diameter of about 4.8 cm and a height of about 10.5 cm, 18.93 g of the second agent was added, 1.07 g of the first agent was added thereto, and the solution was stirred 20 times for 10 seconds. The volumes after 1 minute, 10 minutes and 20 minutes were measured, and the rate of increase in volume relative to the volume before stirring was measured. The results are shown in FIG.

Evaluation Example 3 Skin condition measurement before and after use]
Using the kit of the present invention obtained in Examples 1 to 4 and Comparative Examples 1 and 2 above, a foamable skin external preparation is prepared, and the moisture content of the stratum corneum before and after use of the obtained foamable skin external preparation (measurement Instruments: SKICON-200EX, and elasticity (measuring instrument: Cutometer MPA 580) were measured.
The inside of the forearm of the subject (20's to 30's females 3) was washed with the cleanser and rested in the measuring room for 15 minutes. Next, measurement was performed before using the effervescent skin external preparation. Next, the effervescent skin external preparation was applied to the measurement site and allowed to stand for 10 minutes. Next, the effervescent skin external preparation was removed and washed with water. Fifteen minutes after washing, measurements were taken after using the effervescent skin external preparation. The subject was at rest in the measuring room during the measurement.
The skin condition measurement results after use are shown in Table 3. Table 3 shows the results of measurement of stratum corneum water content and elasticity. Table 3 shows the comparative value which made 1 before foamable skin external preparation use 1 respectively. The moisture content of the stratum corneum indicates that the larger the value, the better, and the elasticity indicates that the larger the value, the better.

Evaluation Example 4 Evaluation of feeling of use of effervescent skin external preparation]
An effervescent skin external preparation is prepared using the kit of the present invention obtained in the above Examples 1 to 4 and Comparative Examples 1 and 2, and the obtained effervescent skin external preparation is used after and after use. The items shown in 4 were evaluated.
First, the inside of the forearm of the subject (20's to 30's females 3) was washed with a cleanser and spent for 15 minutes. Next, the effervescent skin external preparation was applied to the measurement site and allowed to stand for 10 minutes. Next, the effervescent skin external preparation was removed and washed with water. Thereafter, a questionnaire was conducted on eight items (1) to (8) in Table 4. The evaluation of the questionnaire is based on Example 1 with respect to the following items (1) to (8), and the case equivalent to Example 1 is 4 (not both) and 1 (bad) to 7 (good) It evaluated by seven steps and calculated the average score of three persons. The subject was at rest in the measuring room during the measurement.

From Table 2, it is understood that Examples 1 to 4 are liquid compositions having no viscosity in the second agent and exhibiting excellent fluidity. Further, from FIG. 1, the foaming amount of carbon dioxide gas is Example 2> Example 1> Example 4> Example 3> Comparative Example 2 immediately after stirring, and Example 24> Example 4 after 20 minutes. Example 1, 3> Comparative Example 2 From this, it can be understood that carbon dioxide gas can be well held in Examples 1 to 4 as compared with Comparative Example 2.
From Table 3, the condition of the skin after use is as follows: Example 4> Example 2> Example 3> Comparative Example 1> Example 1> Comparative Example 2 good results are obtained in Example 4> Example 2> Comparative Example 2, elasticity Example 2> Example 4> Example 3> Example 1> Comparative Example 1> Good results were obtained in the order of Comparative Example 2. That is, it is understood that Examples 1 to 4 are effective in improving the state after use, as compared with Comparative Examples 1 and 2. In particular, the effects become high in Examples 2 to 4 in which water and a humectant are used in combination It turns out that the skin is kept fresh.
Further, it is understood from Table 4 that the foamable skin external preparation obtained by using the kit of the present invention has a high evaluation at the time of use as compared with Comparative Examples 1 and 2. In particular, it is easy to mix at the time of mixing the first and second agents, easy to apply after mixing, hard to drip, easy to remove after use, and moisturizing, elasticity and lightening of the skin after use, redness of the skin Since the effect which can be confirmed is acquired, it turns out that it is easy for a user to use easily, and the effect to skin is high.
From the above results, it is understood that the foamable skin external preparation obtained by using the kit of the present invention is easy to use for the user and has a high effect on the skin, and in particular, the second agent is water It can be seen that the effects of the present invention are remarkably exhibited when used together with a moisturizer.

<Production of effervescent skin external preparation>
According to the composition shown in Table 5, a kit of the present invention was manufactured. Examples 5 and 6 and Comparative Example 3 were produced in the same manner as Example 1, and Comparative Example 4 was produced in the same manner as Comparative Example 2.

<Characteristics evaluation of effervescent skin external preparation>
According to the following procedure, the properties of the foamable skin external preparation obtained in Examples 5 and 6 and Comparative Examples 3 and 4 were evaluated.
Evaluation Example 5. Evaluation of Second Agent Viscosity]
In the second agent described in Table 5, the viscosities of Examples 5 and 6 and Comparative Examples 3 and 4 were measured using a viscometer (RVT type manufactured by Brookfield, Inc.). The results are shown in Table 5.

Evaluation Example 6. Evaluation of the whitening effect]
The effervescent skin external preparations obtained with the kits of the present invention of Examples 5 and 5 and Comparative Examples 3 and 4 having the compositions shown in Table 5 were evaluated for the whitening effect after use and the feeling in use. Examples 4 and 5 and Comparative Example 3 were prepared in the same manner as Example 1, and Comparative Example 4 was prepared in the same manner as Comparative Example 2. The whitening effect was measured using the skin color difference (measuring device: color difference meter) before and after use.
The inside of the forearm of the test subject (four women in their twenties and thirties) was washed with water and spent in the measurement room for 15 minutes. Next, measurement was performed before using the effervescent skin external preparation. Next, the effervescent skin external preparation was applied to the measurement site and allowed to stand for 10 minutes. Next, the effervescent skin external preparation was removed and washed with water. After 15 minutes, 60 minutes and 120 minutes after washing, the color difference after use of the effervescent skin external preparation was measured. The change value (ΔL * value) of the lightness of the skin after use relative to that before the use of the foamable skin external preparation was determined, and the average value was evaluated. As the ΔL * value increases, the larger the value, the whiter the skin color after use. The subject was at rest in the measuring room during the measurement. The results are shown in Table 7.

Evaluation Example 7. Evaluation of feeling of use of effervescent skin external preparation]
An effervescent skin external preparation is prepared using the kit of the present invention obtained in Examples 5 and 6 and Comparative Examples 3 and 4 above, and the obtained effervescent skin external preparation is used and after use. The items shown in 8 were evaluated.
First, the inside of the forearm of the test subject (four females in their twenties and thirties) was washed with water and spent for 15 minutes. Next, the effervescent skin external preparation was applied to the measurement site and allowed to stand for 10 minutes. Next, the effervescent skin external preparation was removed and washed with water. Thereafter, a questionnaire was conducted on five items (1) to (5) in Table 7. The evaluation of the questionnaire is based on Comparative Example 3 for the items (1) to (5) below, and the equivalent case is 4 (not either), and is evaluated in 7 stages of 1 (bad) to 7 (good) And the average score of 4 people was calculated. The subject was at rest in the measuring room during the measurement.

From Table 6, it can be seen that Examples 5 and 6 are liquid compositions having no viscosity in the second agent and exhibiting excellent flowability.
From Table 7, the effervescent skin external preparation examples 5 and 6 obtained using the kit of the present invention have a ΔL * value of 0.5 or more after 15 minutes of use, and are compared with comparative examples 3 and 4. Showed a high value. Also, after 120 minutes, the ΔL * values of Comparative Examples 3 and 4 are almost 0, which is the same skin color as before use, while the ΔL * values of Examples 4 and 5 are 0.30. It kept the high number above. It can be understood that the skin can be brightened and the brightness can be maintained by using Examples 5 and 6.
It can be seen from Table 8 that the foamable skin external preparation obtained by using the kit of the present invention has a high evaluation at the time of use as compared with Comparative Examples 3 and 4. In particular, it is understood that it is easy to apply to the skin and easy to use for the user. Furthermore, since the moistness of the skin after use and the effect of improving the brightness of the skin are obtained, it can be understood that it is easy for the user to use, and the effect on the skin is high.
From the above results, the effervescent skin external preparation obtained by using the kit of the present invention is effective for skin lightening, in particular for a short time, effective for skin whitening, and easily used by the user. It turns out that it is easy to do. In particular, when the first agent is a powder containing an acidic substance and the second agent is a low-viscosity liquid containing a carbon dioxide gas generating substance, it has a high whitening effect as compared with the comparative example, and the feeling in use Is a good thing.

Below, the specific formulation example of the kit of this invention is shown. Both the first agent and the second agent can be produced by the same production method as the production method of Example 1 or a general cosmetic production method.

Example 7

  According to the formulation described in Table 9, a kit for external preparation for foamable skin was prepared in the same manner as in Example 1. The effervescent skin external preparation can be obtained by mixing the first and second agents of the obtained kit 1: 3.

Example 8

According to the formulation described in Table 10, a kit for an effervescent skin external preparation was prepared in the same manner as in Example 1. The effervescent skin external preparation can be obtained by mixing the first and second agents of the obtained kit at 1: 2.

Example 9

According to the formulation described in Table 11, a kit for external preparation for foamable skin was prepared in the same manner as in Example 1. The effervescent skin external preparation can be obtained by mixing the first and second agents of the obtained kit in a 1: 1 ratio.

Example 10

According to the formulation described in Table 12, a kit for an effervescent skin external preparation was prepared in the same manner as in Example 1. The effervescent skin external preparation can be obtained by mixing the first and second agents of the obtained kit 1:10.

Example 11

According to the formulation described in Table 13, a kit for external preparation for foamable skin was prepared in the same manner as in Example 1. A foamable skin external preparation can be obtained by mixing the first and second agents of the obtained kit 1: 5.

Example 12

  According to the formulation described in Table 14, a kit for external preparation for foamable skin was prepared in the same manner as in Example 1. The effervescent skin external preparation can be obtained by mixing the first and second agents of the obtained kit 1: 3.

Example 13

According to the formulation described in Table 15, a kit for external preparation for foamable skin was prepared in the same manner as in Example 1. The effervescent skin external preparation can be obtained by mixing the first and second agents of the obtained kit at 1: 2.

Example 14

According to the formulation described in Table 16, a kit for effervescent skin external preparation was prepared in the same manner as in Example 1. The effervescent skin external preparation can be obtained by mixing the first and second agents of the obtained kit in a 1: 1 ratio.

  As apparent from the above examination, the kit of the present invention is easy to mix uniformly, and exhibits the effect of uniformly generating carbon dioxide gas at the time of use. Furthermore, it can be seen that, by using the foamable skin external preparation obtained by using the kit of the present invention, the effect of keeping the skin white and fresh is exhibited.

Claims (6)

A kit for obtaining an effervescent skin external preparation, wherein the first agent comprises an acidic substance, and a thickener (except in the case where it contains a hydrophobized modified alkyl cellulose); A kit comprising: a carbon dioxide gas generating substance which reacts with the acidic substance to generate carbon dioxide gas , further contains water and / or a moisturizing agent, and does not contain a thickener. The kit according to claim 1, characterized in that the first agent is a solid composition. The kit according to any one of claims 1 or 2, wherein the second agent is a liquid composition. The kit according to any one of claims 1 to 3, wherein the second agent contains a carbon dioxide gas-generating substance that reacts with the acidic substance to generate carbon dioxide gas, water and a humectant. The kit according to any one of claims 1 to 4, wherein the viscosity of the second agent is 50,000 mPa · s or less. The kit according to any one of claims 1 to 5, wherein the first agent and the second agent are mixed and used in a weight ratio in the range of 1: 0.1 to 1:30.