JP6426635B2 - Composition for alpha gel formation and alpha gel composition - Google Patents

Description

  The present invention relates to compositions for alpha gel formation and to improvements in alpha gel compositions, in particular gel formers.

Conventionally, for the purpose of maintaining the emulsion stability of skin external preparations such as cosmetics, quasi-drugs, and pharmaceuticals, α-gel containing skin using α-gel formed of higher aliphatic alcohol and higher fatty acid and hydrophilic surfactant External preparations have been used. Such alpha gel stabilizes the external preparation for skin with high viscosity, but it has a feeling that it feels nully during application, and also has problems such as higher alcohol and higher fatty acid are easily precipitated as crystals over time. (For example, refer to nonpatent literature 1).
In addition, there are many cases where the viscosity increases with time, and it has been studied to use a two-chain type cationic surfactant or the like as a viscosity increase inhibitor, but a sufficiently good stability has not been obtained. (See, for example, Non-Patent Document 2). Furthermore, the effect of preventing water evaporation from the inside of the skin (occlusion) was not sufficient.
Furthermore, for the purpose of preventing water evaporation from the inside of the skin, similar preparations containing a two-chain type compound such as ceramides, dialkyl quaternary ammonium salts or phospholipids and sterols (for example, Patent Document 1), phospholipids, Preparations containing polyoxyethylene sterol ethers and higher alcohols (for example, Patent Document 2 and Non-patent Document 3) have been used, but phospholipids have problems such as coloring and odor, and crystals of ceramide have There was a problem that it was easy to precipitate out.

Patent No. 5690074 Patent No. 4495941

Kei Watanabe et al., J. Oleo Sci., 61, 29-34 (2012) Makoto Uyama et al., J. Oleo Sci., 62, 9-16 (2013) Yoshino Ogino, Journal of Japanese Cosmetic Engineers, 45, 83-91 (2011)

The present invention has been made in view of the above prior art, and the problem to be solved is to provide a highly stable α-gel forming composition free from coloring, crystal precipitation and the like with time and an α-gel composition using the same It is to do.

  In order to solve the above problems, as a result of intensive studies by the present inventors, higher aliphatic alcohol and / or higher fatty acid, polyoxyethylene sterol ether, and polyoxyethylene dialkyl having two or more hydrophobic groups having 16 or more carbon atoms It has been found that the formation of a novel α-gel composition by containing an ester and / or an ether in a specific ratio leads to the completion of the present invention.

That is, the composition for forming α gel according to the present invention is
(A) 25 to 50 mass% of one or more higher aliphatic alcohol having 16 or more carbon atoms and / or higher fatty acid
(B) 40 to 70 mass% of polyoxyethylene sterol ether represented by the following general formula (I)
(I)

(However, in general formula I, R is a cholesterol and / or phytosterol residue, n is an integer of 5 to 20.)
(C) 5 to 20% by mass of polyoxyethylene dialkyl ester and / or ether represented by the following general formula (II)
(II)

(However, in the general formula II, R 1 and R 2 are linear aliphatic acid residues having 16 to 24 carbon atoms or linear aliphatic alcohol residues, and n is an integer of 4 to 15)
And is added to the aqueous phase to form a gel.

The α-gel composition according to the present invention is characterized in that the above (A) to (C) are formed in the aqueous phase.

In addition, it is preferable that the above-mentioned α-gel composition contains a 2-chain amphiphile having a nitrogen atom in an amount of 0.1 to 10% by mass based on the effective component in the α-gel composition.
In the gel composition, it is preferable that the two-chain amphiphilic substance having a nitrogen atom is one or more selected from phospholipid, lecithin, lysolecithin, ceramide and dialkyl quaternary ammonium salt. is there.

In the composition for .alpha. gel formation, the blending amount of the higher aliphatic alcohol having 16 or more carbon atoms and / or the higher fatty acid is preferably 25 to 50% by mass in the total active ingredients. Examples of higher aliphatic alcohols having 16 or more carbon atoms include cetyl alcohol, cetostearyl alcohol, stearyl alcohol, behenyl alcohol, batyl alcohol and the like. Examples of higher fatty acids include palmitic acid, stearic acid, behenic acid and the like.
In the composition for forming α-gel, the polyoxyethylene sterol ether of (I) is preferably one having phytosterol, cholesterol, ergosterol as a hydrophobic group, and 5 to 30 moles of polyoxyethylene chain is preferable. It is. For example, polyoxyethylene (5 moles) phytosterol (eg, Nikko Chemicals BV, Nikkol BPS-5), polyoxyethylene (10 moles) Phytosterols (eg, Nikko Chemicals BV, Nikkol BPS-10), polyoxy acids Ethylene (20 moles) Phytosterol (eg, Nikko Chemicals BV-20), polyoxyethylene (30 moles) Phytosterol (eg P18 Nikkos BPS-30), polyoxyethylene (10 moles) cholesterol (For example, Emalex CS-10, manufactured by Nippon Emulsion Co., Ltd.) and the like. As a compounding quantity, 40-70 mass% is preferable in all the active ingredients.

In the composition for forming α-gel, the polyoxyethylene dialkyl ester and / or ether of (II) is preferably one having a linear aliphatic acid residue or linear aliphatic alcohol residue having 16 to 24 carbon atoms The polyoxyethylene chain is preferably 4 to 15 moles. Examples include polyoxyethylene (4 moles) distearic acid (eg, Emalex 200 DIS, manufactured by Nippon Emulsion Co., Ltd.), polyoxyethylene (6 moles) distearic acid (eg, Emalex 300 DIS, manufactured by Nippon Emulsion Co., Ltd.), polyoxyethylene 8 moles) distearic acid (eg, Emalex 400 DIS, manufactured by Nippon Emulsion Co., Ltd.), polyoxyethylene (12 moles) distearic acid (eg, Emalex 600 DIS, manufactured by Nippon Emulsion Co., Ltd.), steareth 4 stearate (eg, manufactured by Nippon Emulsion Co., Ltd.) , Emalex SWS-4), Steareth Stearate-6 (eg, Emalex SWS-6, manufactured by Nippon Emulsion Co., Ltd.), Steareth Stearate-9 (eg, Emalex SWS-9, manufactured by Nippon Emulsion Co., Ltd.), polyoxyethylene (8 Mol) dibehenyl ether and the like. The mode of linkage of the polyoxyethylene chain and the alkyl group may be either ester or ether, or both. As a compounding quantity, 5-20 mass% is preferable in all the active ingredients.

The compounding amount of the two-chain amphiphilic substance having a nitrogen atom such as phospholipid, lecithin, lysolecithin, ceramide and dialkyl quaternary ammonium salt is 0.1 to 10% by mass with respect to the effective component in the α gel composition. It is suitable. If the content is 0.1% by mass or less, the effect is poor, and if it is 10% by mass or more, stability problems such as coloring and crystal precipitation easily occur.
In addition, although the above-mentioned α gel composition can be blended in any amount in the skin external preparation composition, it is generally 0.1 to 20 mass as an active ingredient in the α gel composition in the skin external preparation. % Is preferred.

The α-gel composition according to the present invention and the external skin preparation composition characterized in that it is blended are refreshing during application, and after application, they are highly effective in preventing water evaporation from the inside of the skin (occlusion). Even if two chain type amphiphilic substances having nitrogen atoms such as phospholipid, lecithin, lysolecithin, ceramide and dialkyl quaternary ammonium salts are mixed together, stability problems such as coloring and crystal precipitation do not occur over time .

It is a phase equilibrium diagram of the ternary system of 50 mass% solvent water of an effective part of polyoxyethylene (6 mol) distearic acid-stearyl alcohol-polyoxyethylene (10 mol) phytosterol prepared at 25 ° C according to the present invention. It is a X-ray-scattering spectrum of * mark of FIG. 1 concerning this invention. It is an X-ray-scattering spectrum of 50 mass% solvent water of polyoxyethylene (6 mol) distearic acid-stearic acid-polyoxyethylene (10 mol) phytosterol = 2: 2: 6 concerning this invention.

Hereinafter, the configuration of the present invention will be described in detail.
The α-gel composition according to the present invention comprises one or more kinds of higher aliphatic alcohols having 16 or more carbon atoms and / or 25 to 50% by mass of higher fatty acids, 40 to 70% by mass of polyoxyethylene sterol ether, and polyoxy By dissolving 5 to 20% by mass of ethylene dialkyl ester and / or ether at 70 to 80 ° C., adding ion exchanged water of 70 to 80 ° C. at a ratio of 40 to 90% by mass, stirring and cooling can get. Also, one or two or more higher aliphatic alcohol having 16 or more carbon atoms and / or 25 to 50% by mass of higher fatty acid, 40 to 70% by mass of polyoxyethylene sterol ether, and polyoxyethylene dialkyl ester and / or ether After melting 5 to 20% by mass at 70 to 80 ° C., a 2-chain amphiphilic substance having a nitrogen atom such as phospholipid, lecithin, lysolecithin, ceramide or dialkyl quaternary ammonium salt is added and melted, It is obtained by adding and cooling ion-exchange water of 70-80 degreeC to this by the ratio of 40-90 mass%, and stirring. In addition, generally, an alpha gel is an aggregate formed by higher aliphatic alcohol and a hydrophilic surfactant in water, and is a gel having an alpha structure ("Physicochemistry of cetyl alcohol" Fragrances Journal, Inc. by Shoji Fukushima) Means

  As a specific example of the α gel composition, polyoxyethylene (10 moles) phytosterol (one or two or more kinds of higher aliphatic alcohol having 16 or more carbon atoms and / or higher fatty acid stearyl alcohol) as polyoxyethylene sterol ether For example, Nikkol BPS-10) manufactured by Nikko Chemicals Co., Ltd. is selected as polyoxyethylene dialkyl ester and / or ether, and polyoxyethylene (6 moles) distearic acid (for example, Emalex 300 DIS manufactured by Nippon Emulsion Co., Ltd.) is selected. These mixtures were brought into one phase at 70 to 80 ° C., and ion-exchanged water heated to the same temperature was added so that the total effective amount became 60% by mass of the whole, and cooled to room temperature. The phase equilibrium diagram of the ternary system is shown in FIG. The hatched area in FIG. 1 is a region where a scattering peak (FIG. 2) indicating α gel is obtained as a result of X-ray analysis with a single melting point peak in a differential thermal analyzer. In addition, FIG. 2 is an X-ray scattering spectrum of the composition shown by * mark of FIG.

Also, even when stearyl alcohol was changed to stearic acid, an X-ray scattering spectrum was obtained that also suggested α gel (FIG. 3). As apparent from FIG. 1, α gel is formed in the region of 25 to 50% by mass of stearyl alcohol, 40 to 70% by mass of polyoxyethylene (10 mol) phytosterol, and 5 to 20% by mass of polyoxyethylene (6 mol) distearic acid That was confirmed.

In the present invention, an α-gel can be constructed using only the above three components, but if necessary for the purpose of improving skin roughness etc., a two-chain type having a nitrogen atom such as phospholipid, lecithin, lysolecithin, ceramide, dialkyl quaternary ammonium salt, etc. Amphiphilic substances can also be blended together.

  The oil component used for the external preparation for skin of the present invention is not particularly limited, and, for example, liquid oil and fat, solid oil and fat, waxes, hydrocarbon oil, higher fatty acid, synthetic ester oil, silicone oil and the like can be appropriately blended. Furthermore, it is also possible to dissolve and emulsify some higher alcohol in the above-mentioned oil. Although it does not specifically limit as a compounding quantity with respect to the objective alpha gel containing skin external preparation, 0.05-50 mass% is preferable. If the amount is less than 0.05% by mass, the effect as an external preparation for the skin is poor, and if it exceeds 50% by mass, the use feeling becomes worse.

Examples of liquid oils and fats include avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, sasanqua oil, castor oil, linseed oil And safflower oil, cottonseed oil, eno oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, Japanese oak oil, Japanese tung oil, jojoba oil, germ oil, triglycerin and the like.
As solid fats and oils, for example, cacao butter, coconut oil, horse fat, hydrogenated coconut oil, palm oil, beef tallow, sheep fat, hydrogenated beef tallow, palm kernel oil, pork fat, beef bone fat, mokurou kernel oil, hydrogenated oil, beef Examples include foot fat, wax wax, hydrogenated castor oil and the like.
Examples of the waxes include beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, ivory wax, persimmon wax, montan wax, nuka wax, lanolin, kapok wax, lanolin acetate, liquid lanolin, sugar cane wax, lanolin fatty acid isopropyl, hexyl laurate, reduced lanolin , Jojoba wax, hard lanolin, shellac wax, polyoxyethylene lanolin alcohol ether, polyoxyethylene lanolin alcohol acetate, polyoxyethylene cholesterol ether, lanolin fatty acid polyethylene glycol, polyoxyethylene hydrogenated lanolin alcohol ether, cetyl palmitate, etc. .
Examples of hydrocarbon oils include liquid paraffin, ozokerite, squalane, pristane, paraffin, ceresin, squalene, vaseline, microcrystalline wax and the like.

Examples of higher fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, undecylenic acid, tallic acid, isostearic acid, linoleic acid, linoleic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid ( DHA) and the like.
Examples of synthetic ester oils include cetyl octanoate, myristyl myristate, glyceryl tri-2-ethylhexanoate, pentaerythritol tetra2-ethylhexanoate, dioctyl succinate, tripropylene glycol dineopentanoate, and the like.
As silicone oil, for example, linear polysiloxane (for example, dimethylpolysiloxane, methylphenylpolysiloxane, diphenylpolysiloxane and the like); cyclic polysiloxane (for example, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexene) Silicone resin, silicone rubber, various modified polysiloxanes (amino modified polysiloxane, polyether modified polysiloxane, alkyl modified polysiloxane, fluorine modified polysiloxane etc.), acrylic silicone And the like.

The α-gel-containing external skin preparation according to the present invention can be used, for example, in skin cosmetics, hair cleansing agents, skin cleansing agents, hair styling agents, etc. that can be applied to the body such as skin and hair.
In addition to the above-mentioned essential components, components for use in cosmetics, medicines, etc. can be added to the alpha gel-containing external skin preparation according to the present invention in such amounts that do not affect the stability. . Such components include, for example, powder components, amphoteric surfactants, ionic surfactants, nonionic surfactants, moisturizers, thickeners, film agents, UV absorbers, sequestering agents, pH adjusters, Skin nutrients, vitamins, antioxidants, antioxidant aids, perfumes, etc. may be mentioned.

  As a powder component, for example, inorganic powder (for example, talc, kaolin, mica, sericite (sericite), muscovite, phlogopite, synthetic mica, pyromica, biotite, vermiculite, bentonite, hectorite, laponite, carbonate Magnesium, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, tungstate metal salt, magnesium, silica, zeolite, barium sulfate, calcined calcium sulfate (gypsum gypsum), calcium phosphate, fluorine Apatite, hydroxyapatite, ceramic powder, metal soap (eg, zinc myristate, calcium palmitate, aluminum stearate), boron nitride, etc .; organic powder (eg, polyamide resin powder (nylon powder), polyethylene powder, Methyl polymethacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, benzoguanamine resin powder, polytetrafluoroethylene powder, cellulose powder, etc .; Inorganic white pigment (eg, titanium dioxide, zinc oxide etc.); Inorganic red pigments (eg iron oxide (iron), iron titanate etc.); inorganic brown pigments (eg γ-iron oxide etc); inorganic yellow pigments (eg yellow iron oxide, yellow earth etc); inorganic black Based pigments (for example, black iron oxide, lower order titanium oxide, etc.); Inorganic purple pigments (for example, mango violet, cobalt violet etc.); Inorganic green pigments (eg, chromium oxide, chromium hydroxide, cobalt titanate etc.) Inorganic blue pigments (eg, ultramarine blue, bituminous, etc.); pearl pigments (eg, titanium oxide coated mica, titanium oxide coated oxy oxychloride bismuth oxide) Titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, fish scale foil, etc .; metal powder pigments (eg, aluminum powder, kappa powder etc.); organic pigments such as zirconium, barium or aluminum lake (eg, red 201) , Red 202, Red 204, Red 205, Red 220, Red 226, Red 228, Red 405, Orange 203, Orange 204, Yellow 205, Yellow 401, and Blue 404 And other organic pigments, Red No. 3, Red No. 104, Red No. 106, Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 202 No. 203, Green No. 3 and Blue No. 1); Natural dyes (eg, chlorophyll, β-carotene etc.), etc. That.

Examples of amphoteric surfactants include imidazoline amphoteric surfactants (eg, 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide). Side-1-carboxyethyloxy disodium salt and the like); betaine surfactants (eg, 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryl dimethylaminoacetic acid betaine, alkyl betaine, amido betaine) And sulfobetaine etc.).
Examples of the ionic surfactant include N-acylmethyl taurine salts, N-acyl glutamates, alkyl sulfates, polyoxyethylene alkyl sulfates, fatty acid soaps, alkyl quaternary ammonium salts and the like.

  Examples of lipophilic nonionic surfactants include sorbitan fatty acid esters (eg, sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, Sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexyl acid, diglycerol sorbitan tetra-2-ethylhexyl acid, etc. Glycerin polyglycerin fatty acids (eg mono cotton seed oil fatty acid glycerin, monoerlucate glycerin, sesquioleic acid glycerin, monostearin Acid glycerin, α, α'-oleic acid pyroglutamic acid glycerin, monostearic acid glycerin malic acid, etc .; propylene glycol fatty acid esters (eg, monostearic acid) Acid propylene glycol and the like); hardened castor oil derivatives; glycerin alkyl ether and the like.

  As a hydrophilic nonionic surfactant, for example, polyoxyethylene sorbitan fatty acid esters (eg, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan Tetraoleate etc.); polyoxyethylene sorbite fatty acid esters (eg, polyoxyethylene sorbite monolaurate, polyoxyethylene sorbite monooleate, polyoxyethylene sorbite pentaoleate, polyoxyethylene sorbite monostearate etc); Polyoxyethylene glycerin fatty acid esters (eg, polyoxyethylene glycerin monostearate, polyoxyethylene glycerin monoisostearate Polyoxyethylene monooleate such as polyoxyethylene glycerin triisostearate); polyoxyethylene fatty acid esters (eg, polyoxyethylene distearate, polyoxyethylene monodioleate, ethylene glycol distearate etc); Polyoxyethylene alkyl ethers (for example, polyoxyethylene lauryl ether, polyoxyethylene oleyl ether, polyoxyethylene stearyl ether, polyoxyethylene behenyl ether, polyoxyethylene 2-octyldodecyl ether, polyoxyethylene cholestanol ether, etc.) Pluronic types (eg, pluronic etc.); polyoxyethylene / polyoxypropylene alkyl ethers (eg, polyoxyethylene / polyoxy) Cipropylene cetyl ether, polyoxyethylene / polyoxypropylene 2-decyl tetradecyl ether, polyoxyethylene / polyoxypropylene monobutyl ether, polyoxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene / polyoxypropylene glycerin ether, etc. Tetraoxyethylene · tetrapolyoxypropylene ethylenediamine condensates (for example, Tetronic etc.); polyoxyethylene castor oil hydrogenated castor oil derivative (for example, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, polyoxy acid) Ethylene-cured castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearate Diester, polyoxyethylene hydrogenated castor oil, maleic acid etc.); polyoxyethylene beeswax lanolin derivatives (eg, polyoxyethylene sorbite beeswax etc.); alkanolamides (eg, coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanol Polyamides, ethylene glycol glycol fatty acid esters, polyoxyethylene alkylamines, polyoxyethylene fatty acid amides, sucrose fatty acid esters, alkylethoxydimethylamine oxide, trioleyl phosphate and the like.

  Examples of natural water-soluble polymers include plant-based polymers (eg, gum arabic, tragacanth gum, galactan, guar gum, carob gum, karaya gum, locust bean gum, tamarind gum, carrageenan, pectin, agarten, quince seed (maleo), Alge colloid (caustic extract), starch (rice, corn, potato, wheat), glycyrrhizinic acid; microbial macromolecule (for example, xanthan gum, dextran, succinoglucan, bululin etc.); animal macromolecule (for example, collagen, casein , Albumin, gelatin etc.).

  Examples of semi-synthetic water-soluble polymers include starch-based polymers (for example, carboxymethyl starch, methyl hydroxypropyl starch and the like); cellulose-based polymers (methyl cellulose, ethyl cellulose, methyl hydroxypropyl cellulose, hydroxyethyl cellulose, cellulose sodium sulfate) , Dialkyldimethyl ammonium sulfate cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, carboxymethyl cellulose sodium, crystalline cellulose, cellulose powder and hydrophobic modified compounds of these polymers <Example: partially modified with stearoxy> cationic modified compounds of these polymers, etc.) Alginic acid based polymers (eg, sodium alginate, alginic acid propylene glycol ester, etc.); sodium pectate etc. It is below.

  Examples of synthetic water-soluble polymers include vinyl polymers (eg, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, carboxyvinyl polymer, etc.); polyoxyethylene polymers (eg, polyethylene glycol 20,000, 40,000, 60,000) (Polyoxyethylene-polyoxypropylene copolymer etc.); poly (dimethyldiallyl ammonium halide) type cationic polymer (for example, Mercot 100 (Merquat 100) manufactured by US Merck & Co., Inc.); copolymer type cation of dimethyldiallyl ammonium halide and acrylamide Polymers (for example, Mercot 550 (Merquat 550) manufactured by Merck, USA); acrylic polymers (for example, sodium polyacrylate, polyethyl acrylate, polyacrylamide etc.); polyethyleneimine; cationic poly Mer; AlMg silicate (bee gum), etc. may be mentioned.

  Examples of UV absorbers include benzoic acid UV absorbers (for example, paraaminobenzoic acid (hereinafter referred to as PABA), PABA monoglycerin ester, N, N-dipropoxy PABA ethyl ester, N, N-diethoxy PABA ethyl ester N, N-dimethyl PABA ethyl ester, N, N-dimethyl PABA butyl ester, N, N-dimethyl PABA ethyl ester, etc.); anthranilic acid-based UV absorbers (eg, homomentyl-N-acetyl anthranilate etc.); Salicylic acid based UV absorbers (eg, amyl salicylate, menthyl salicylate, homomentyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate, etc.); cinnamic acid based UV absorbers (eg, octyl cinnamate, ethyl- 4-isopropyl cinnamate, methi -2,5-diisopropylcinnamate, ethyl-2,4-diisopropylcinnamate, methyl-2,4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxy Cinnamate, octyl-p-methoxycinnamate (2-ethylhexyl-p-methoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenyl Cinnamate, 2-ethylhexyl-α-cyano-β-phenylcinnamate, glyceryl mono-2-ethylhexanoyl-diparamethoxycinnamate, etc .; benzophenone type UV absorbers (eg, 2,4-dihydroxybenzophenone, 2 , 2'-Dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone , 2,2 ', 4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfone Acid salts, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone etc .; 3- ( 4'-methylbenzylidene) -d, l-camphor, 3-benzylidene-d, l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5-methylphenylbenzotriazole; 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole; 2- (2′-hydroxy-5′-methylphenylbenzotriazole; dianisoylmethane; 4-methoxy-4′-t-butyldibenzoylmethane 5- (3) 3, 3-Dimethyl-2-norbornylidene) -3-pentan-2-one, etc.); triazine UV absorbers (eg, 2-4 [(2-hydroxy-3-dodecyloxypropyl) oxy] -2-hydroxyphenyl) ) -4,6-Bis (2,4-dimethylphenyl) -1,3,5-triazine, 2-4 [(2-hydroxy-3-tridecyloxypropyl) oxy] -2-hydroxyphenyl) -4 , 6-bis (2,4-dimethylphenyl) -1,3,5-triazine etc.).

  As a sequestering agent, for example, 1-hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, edetate disodium, edetate trisodium, edetate tetrasodium Sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, edetic acid, trisodium ethylenediaminehydroxyethyl triacetate and the like.

Examples of pH adjusters include buffers such as lactic acid-sodium lactate, citric acid-sodium citrate, and succinic acid-sodium succinate.
Examples of vitamins include vitamin A, B1, B2, B6, C, E and derivatives thereof, pantothenic acid and derivatives thereof, biotin and the like.
Examples of the antioxidant include tocopherols, dibutylhydroxytoluene, butylhydroxyanisole, gallic acid esters and the like.

  Examples of the antioxidant aid include phosphoric acid, citric acid, ascorbic acid, maleic acid, malonic acid, succinic acid, fumaric acid, kephalin, hexametaphosphate, phytic acid, ethylenediaminetetraacetic acid and the like.

  Other components which can be incorporated include, for example, preservatives (ethylparaben, butylparaben, 1,2-alkanediol, phenoxyethanol, methylchloroisothiozoline etc.); anti-inflammatory agents (eg, glycyrrhizin acid derivative, glycyrrhetinic acid derivative, Salicylic acid derivatives, hinokitiol, zinc oxide, allantoin, etc .; Whitening agents (eg, Yukinoshita extract, arbutin etc.); Various extracts (eg, Oupaku, ouren, shikon, peony, cerebrum, birch, sage, loquat, carrot, aloe , Zebra oasis, iris, grape, yokinin, oats, lily, saffron, sage, sage, oonilis, ononis, garlic, pepper, chinpi, seaweed etc., activator (eg royal jelly, photosensitizer, cholesterol) Conductors and the like); blood circulation promoting agents (eg, nonyl acid warenylamide, nicotinic acid benzyl ester, nicotinic acid β-butoxyethyl ester, capsaicin, zingerone, cantaristine key, ictamol, tannic acid, α-borneol, tocopherol nicotinate, inositol hexahydrate Nicotinate, cichrandelate, cinnarizine, trazoline, acetylcholine, verapamil, cephalantin, γ-oryzanol etc .; antiseborrhoeic agent (eg sulfur, thianthol etc.); anti-inflammatory agent (eg tranexamic acid, thiotaurine, hypotaurine etc) And aromatic alcohols (benzyl alcohol, benzyloxyethanol etc.) and the like.

In addition, other ingredients such as perfumes and scrub agents can be appropriately blended within the range that does not impair the stability.

Hereinafter, the present invention will be described in more detail by way of examples, but the present invention is not limited thereto. In addition, about a compounding quantity, it shows by the mass% unless there is particular mention.

[Comparison of alpha gel occlusion effect]
The compositions according to the following examples and comparative examples were prepared with an ultrasonic homogenizer at 70 ° C., cooled, uniformly coated on paper at a rate of 5 mg / cm 2 each, and allowed to stand for 1 day. After putting 5 mL of water in a 25 mL vial in a constant temperature and humidity chamber (23 ° C., relative humidity = 45%), immediately fix the filter paper on the lid of the vial and fix the amount of water evaporation at the passage Was measured. The water evaporation rate (decay mass%) per hour was defined as the water evaporation rate constant (% / hour). Therefore, the smaller the moisture evaporation rate constant (% / hour), the higher the ability to retain water.

Example 1
Blending amount (1) Stearyl alcohol 12.5%
(2) Polyoxyethylene (10 moles) phytosterol 30.0%
(3) Polyoxyethylene (6 moles) distearic acid 7.5%
(4) Ion-exchanged water 50.0%

Example 2
Compounding amount (1) Stearic acid 12.5%
(2) Polyoxyethylene (10 moles) phytosterol 30.0%
(3) Polyoxyethylene (6 moles) distearic acid 7.5%
(4) Ion-exchanged water 50.0%

Example 3
Compounding amount (1) Behenyl alcohol 15.0%
(2) Polyoxyethylene (20 moles) phytosterol 30.0%
(3) Polyoxyethylene (4 moles) distearic acid 5.0%
(4) Ion-exchanged water 50.0%

Comparative Example 1
Compounding amount (1) Behenyl alcohol 34.1%
(2) N-stearoyl methyl taurine sodium 15.9%
(3) Ion-exchanged water 50.0%

Comparative example 2
Compounding amount (1) Behenyl alcohol 30.0%
(2) Polyoxyethylene (20 moles) behenyl ether 20.0%
(3) Ion-exchanged water 50.0%

Comparative example 3
Blending amount (1) Stearyl alcohol 12.5%
(2) Polyoxyethylene (10 moles) phytosterol 30.0%
(3) Soy Hydrogenated Resin Resinol 7.5%
(4) Ion-exchanged water 50.0%

Results The results are shown in Table 1. As is clear from Table 1, the alpha gels (Examples 1 to 3) of the present invention are behenyl alcohol and N-stearoylmethyltaurine sodium, behenyl alcohol and polyoxyethylene (20 moles) behenyl ether, stearyl alcohol and polyoxyethylene (10 The occluding effect was found to be higher than that of Comparative Examples 1 to 3 of Comparative Examples 1 to 3 in which the molar sterol and soybean hydrogenated resin were used.

[Viscosity stability test]
Furthermore, the base of each of Examples 1 to 3 and Comparative Examples 1 to 3 is diluted 10 times with ion exchange water at 75 ° C., stored at each temperature of 0 to 50 ° C., and the viscosity over time is 30 ° C. After holding for 30 minutes or longer, the viscosity (mPa · s) was measured with a B-type viscometer.
Results The results are shown in Table 2. As apparent from the table, in Examples 1 to 3 and Comparative Example 3, the viscosity was stable, but in Comparative Examples 1 and 2, thickening over time was observed. In addition, the strange smell was recognized by the comparative example 3 whose viscosity was stable.

[Odor stability]
The bases of Examples 4 to 6 and Comparative Examples 4 to 6 are each diluted 10-fold with ion-exchanged water at 75 ° C., stored at each temperature of 50 ° C., and the odor after one month is obtained by a specialized panel. It judged by the following judgment criteria.

Judgment criteria :: no problem :: somewhat strange odor, x: strange odor

Example 4
Blending amount (1) Stearyl alcohol 12.5%
(2) Polyoxyethylene (10 moles) phytosterol 30.0%
(3) Polyoxyethylene (6 moles) distearic acid 6.0%
(4) Soy hydrogenation hydrogenated resinol 1.5%
(5) Ion-exchanged water 50.0%

Example 5
Compounding amount (1) Stearic acid 12.5%
(2) Polyoxyethylene (10 moles) phytosterol 30.0%
(3) Polyoxyethylene (6 moles) distearic acid 7.0%
(4) Ceramide III 0.5%
(5) Ion-exchanged water 50.0%

Example 6
Compounding amount (1) Behenyl alcohol 15.0%
(2) Polyoxyethylene (20 moles) phytosterol 30.0%
(3) Polyoxyethylene (4 moles) distearic acid 4.8%
(4) Distearyl quaternary ammonium chloride 0.2%
(5) Ion-exchanged water 50.0%

Comparative example 4
Compounding amount (1) Behenyl alcohol 34.1%
(2) N-stearoylmethyltaurine sodium 14.4%
(3) Soy hydrogenation hydrogenated resinol 1.5%
(4) Ion-exchanged water 50.0%

Comparative example 5
Compounding amount (1) Behenyl alcohol 30.0%
(2) Polyoxyethylene (20 moles) behenyl ether 19.5%
(3) Ceramide III 0.5%
(4) Ion-exchanged water 50.0%

Comparative example 6
Blending amount (1) Stearyl alcohol 12.5%
(2) Polyoxyethylene (10 moles) phytosterol 30.0%
(3) Distearyl quaternary ammonium chloride 7.5%
(4) Ion-exchanged water 50.0%

Results The results are shown in Table 3. As apparent from Table 3, by using the α-gel composition of the present invention, it is possible to change the odor of a two-chain amphiphilic substance having a nitrogen atom such as phospholipid, lecithin, lysolecithin, ceramide, dialkyl quaternary ammonium salt, etc. It turned out that

Hereinafter, the present invention will be further described with reference to more specific examples, but the present invention is not limited thereto.
Example 7
Emulsion content (mass%)
(1) Stearyl alcohol 1.3
(2) Polyoxyethylene (10 moles) phytosterol 3.0
(3) Polyoxyethylene (6 moles) distearic acid 0.6
(4) Dipropylene glycol 5.0
(5) Flavoring agent 0.1
(6) Tetraerythritol 2-ethylhexanoic acid pentaerythritol 2.0
(7) α-olefin oligomer 3.0
(8) Dimethylpolysiloxane 2.0
(Shin-Etsu Chemical Co., Ltd., silicone KF96-A6T)
(9) Purified Vaseline 1.0
(10) 1,3-butylene glycol 2.0
(11) Phenoxyethanol 0.5
(12) Glycerin 4.0
(13) Carboxyvinyl polymer 0.03
(14) Potassium hydroxide 0.01
(15) tranexamic acid 0.1
(16) citric acid 0.02
(17) Sodium citrate 0.08
(18) Ion-exchanged water residue (process)
The emulsion was obtained by emulsification according to a conventional method. The obtained emulsion had a high occluding effect, was refreshing, and had good viscosity stability and odor stability.

Example 8
Amount of cosmetic solution (mass%)
(1) N-stearoyl methyl taurine sodium 0.01
(2) Stearyl alcohol 0.13
(3) Polyoxyethylene (10 moles) phytosterol 0.3
(4) Polyoxyethylene (6 moles) distearic acid 0.06
(5) Liquid paraffin 0.78
(6) Methylphenylpolysiloxane 0.2
(Shin-Etsu Chemical Co., Ltd., silicone KF56)
(7) Perfume 0.02
(8) Polyoxyethylene (14 moles) propylene (7 moles) dimethyl ether 0.5
(9) Glycerin 3.0
(10) Dipropylene glycol 5.0
(11) 1,3-butylene glycol 3.0
(12) Citric acid 0.02
(13) Sodium citrate 0.08
(14) EDTA2Na · 2H2O 0.01
(15) General alcohol 95% 5.0
(16) Phenoxyethanol 0.5
(17) Ion-exchanged water residue (process)
The above cosmetic liquid was obtained by emulsifying according to a conventional method. The cosmetic solution obtained had a high occluding effect, was refreshing, and had good viscosity stability and odor stability.

Example 9
Emulsion content (mass%)
(1) Stearyl alcohol 1.3
(2) Polyoxyethylene (10 moles) phytosterol 3.0
(3) Polyoxyethylene (6 moles) distearic acid 0.6
(4) Soy hydrogenated hydrogenated resinol 0.2
(5) isoprene glycol 4.5
(6) 1,4-butanediol 1.5
(7) Perfume 0.09
(8) Glyceryl tristearate 2.5
(9) Squaran 4.5
(10) Dimethylpolysiloxane 1.0
(Shin-Etsu Chemical Co., Ltd., silicone KF96-A6T)
(11) Propylene glycol 7.0
(12) erythritol 1.3
(13) Dynamite Glycerin 6.0
(14) Phenoxyethanol 0.3
(15) Xanthan gum 0.5
(16) Sodium hexametaphosphate 0.03
(17) Ion-exchanged water residue (process)
The emulsion was obtained by emulsification according to a conventional method. The obtained emulsion had a high occluding effect, was refreshing, and had good viscosity stability and odor stability.

Example 10
Amount of sunscreen cream (mass%)
(1) Behenyl alcohol 1.5
(2) Polyoxyethylene (20 moles) phytosterol 3.0
(3) Polyoxyethylene (4 moles) distearic acid 0.5
(4) Ceramide II 0.2
(5) Dipropylene glycol 6.0
(6) Perfume 0.08
(7) Glyceryl tri 2-ethylhexanoate 2.0
(8) Di 2-ethylhexyl succinate 3.0
(9) p-Methoxycinnamic acid 2-ethylhexyl 5.0
(10) Avobenzone 3.0
(11) Bisethylhexyl oxyphenol methoxyphenyl 1.0
Triazine
(12) 1,3-butylene glycol 5.0
(13) Phenoxyethanol 0.5
(14) Glycerin 9.0
(15) EDTA-3 sodium salt 0.1
(16) erythritol 0.1
(17) citric acid 0.02
(18) Sodium citrate 0.08
(19) Ion exchange water residual

(Manufacturing method)
The emulsion was emulsified according to a conventional method to obtain the above-mentioned sunscreen cream. The resulting sunscreen cream had a high occluding effect, was refreshing, and had good viscosity stability and odor stability.

Example 11
Amount of cream (mass%)
(1) Stearyl alcohol 2.5
(2) Polyoxyethylene (10 moles) phytosterol 6.0
(3) Polyoxyethylene (6 moles) distearic acid 1.2
(4) 1,3-butylene glycol 6.5
(5) Perfume 0.05
(6) Dimethylpolysiloxane 7.4
(Shin-Etsu Chemical Co., Ltd., silicone KF96-A6T)
(7) Squaran 4.0
(8) Purified Vaseline 1.0
(9) Dipropylene glycol 5.0
(10) Phenoxyethanol 0.5
(11) Glycerin 7.0
(12) EDTA-3 sodium salt 0.1
(13) Chamomile extract 0.1
(14) Citric acid 0.02
(15) Sodium citrate 0.08
(Manufacturing method)
Emulsify by a conventional method to obtain a cream. The obtained cream had a high occluding effect, was refreshing, and had good viscosity stability and odor stability.

Claims (5)

(A) 25 to 50 mass% of one or more higher aliphatic alcohol having 16 or more carbon atoms and / or higher fatty acid
(B) 40 to 70 mass% of polyoxyethylene sterol ether represented by the following general formula (I)

(I)

(However, in general formula I, R is a cholesterol and / or phytosterol residue, n is an integer of 5 to 20.)
(C) 5 to 20% by mass of polyoxyethylene dialkyl ester and / or ether represented by the following general formula (II)
(II)

(However, in the general formula II, R 1 and R 2 are linear aliphatic acid residues having 16 to 24 carbon atoms or linear aliphatic alcohol residues, and n is an integer of 4 to 15)
And a composition for forming an alpha gel formed by adding water .
The alpha gel composition prepared by mix | blending (A)-(C) of Claim 1 in water.
The alpha gel composition according to claim 2, further comprising 0.1 to 10% by mass of a two-chain amphiphile having a nitrogen atom with respect to the effective component in the alpha gel composition. Composition.
The α-gel composition according to claim 3, wherein the two-chain amphiphilic substance having a nitrogen atom is one or more selected from phospholipids, lecithin, lysolecithin, ceramide and dialkyl quaternary ammonium salts. An alpha gel composition comprising:
  The skin external preparation composition which mix | blends the alpha gel composition of Claim 2.