JP6499873B2 - Specimen automation system - Google Patents

Description

The present invention relates to a sample test automation system having a serum information measurement function for determining the state of a sample (hemolysis, chyle, jaundice).

  Some specimen test automation systems incorporate a function (serum information measurement unit) that determines the state of a specimen (hemolysis, chyle, jaundice) based on the serum color.

  With this function, for example, it has become possible to automatically sort hemolyzed specimens in advance, and to identify specimens having low hemolysis or turbidity before being transported to an automatic analyzer.

As a prior art, Japanese Patent Application Laid-Open No. 63-103945 (Patent Document 1) discloses an invention for measuring serum information. Japanese Patent Laying-Open No. 2013-242246 (Patent Document 2) discloses an invention in which serum information can be specified more accurately by attaching a specific color to the back side of a barcode and comparing it with the color of a specimen. Yes.

JP-A 63-103945 JP 2013-242246 A

  Depending on the analysis result, it may be necessary to re-analyze a specific item for a specific sample. In the conventional system, in the case of reanalysis, either the method that allows all samples to be reanalyzed to stop at the serum information measurement unit or the method that does not uniformly stop at the serum information measurement unit can be selected. there were.

  In the former method in which all the specimens stop at the serum information measurement unit at the time of reanalysis, normal specimens with low necessity for remeasurement of serum information also drop at the serum information measurement unit. Normally, normal samples occupy most of the samples, so the number of samples that stop at the serum information measurement unit during reanalysis increases, and the probability of overlapping with the input timing of the target sample for the initial analysis increases, which may cause congestion. There wasn't.

  On the other hand, in the latter method in which all samples are not brought to the serum information measurement unit at the time of reanalysis, a sample that is changed to a state different from the initial determination result is not assumed at the time of retesting. For example, if it is in a state of low hemolysis (a level in which component analysis by an automatic analyzer can be continued) at the first time, it can be directly transferred to the analyzer for analysis at the time of the first analysis. Thereafter, even if the hemolysis progresses until the reanalysis and is changed to high hemolysis (the degree to which analysis by an automatic analyzer is refrained because it may affect the component analysis), the reanalysis is executed as it is. Since the change to high hemolysis was revealed for the first time based on the reanalysis results, the high hemolysis state was eliminated and another component analysis (re-analysis) was required, which could cause unnecessary consumption of reagents. Further, even for a sample determined to be chyle at the time of the first analysis, there is a possibility that the lipid component is precipitated and the turbidity of the sample is eliminated before reanalysis is started. In order to perform such reanalysis of the specimen, a visual confirmation operation by a user and a manual re-input operation to the system are required.

An object of the present invention is to provide a system that eliminates a potential factor of congestion and realizes a workflow that pursues saving of reagents and work load.

In order to solve the above problems, for example, the configuration described in the claims is adopted. The present application includes a plurality of means for solving the above-described problems. To give an example , a color information acquisition device that acquires color information from a sample derived from a living organism, a storage device that stores the sample, and a sample A control device that controls the transport path of the sample, the control device in the first analysis regarding the sample state determination unit that determines the sample state based on the acquired color information, the acquired color information or the sample state When a request for reanalysis or additional analysis is generated for a sample stored in the storage device and a storage unit that stores information used for determining a workflow, the information stored in the storage device is stored. The color information acquisition unit includes a determination unit that determines a workflow including whether or not to drop a sample based on information.

Among the inventions disclosed by the present application, effects obtained by typical ones will be briefly described as follows. In other words, the effect obtained by the typical one can provide a system that eliminates the potential for causing congestion, and realizes a workflow that leads to saving of reagents and reduction of the work burden on the user.

1 is a configuration diagram showing an overall configuration of a sample test automation system according to an embodiment of the present invention. It is the schematic explaining the concept of the workflow of the sample which concerns on one embodiment of this invention. It is a figure explaining the example of the sample used for the system concerning one embodiment of the present invention. It is a flowchart explaining the method to determine the workflow of the sample which concerns on one embodiment of this invention. It is a figure explaining the example of the setting screen of the threshold value which concerns on one embodiment of this invention. It is a figure which shows the example of a setting screen which switches the serum information measurement system at the time of the reanalysis based on one embodiment of this invention. It is the schematic explaining the concept of the workflow of the sample which concerns on another one Embodiment of this invention. It is a top view of the dispensing module in which the reagent addition mechanism concerning another embodiment of the present invention was installed. It is a front view of the reagent addition mechanism concerning another embodiment of the present invention. It is a flowchart explaining the determination method of the workflow of the sample in the system provided with the reagent addition mechanism which concerns on another embodiment of this invention.

  Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings. The following embodiments are representative examples relating to the realization of the basic concept in the above-described invention.

  FIG. 1 is a configuration diagram showing the overall configuration of a sample test automation system according to an embodiment of the present invention. This embodiment shows a configuration in which the storage unit 300 is installed at the left end of the system as a representative example. Note that the system configuration is not limited to the present embodiment, and the storage unit 300 can be installed at the right end of the system 1 as shown in a conceptual diagram of FIG.

  In FIG. 1, the specimen test automation system 1 has a transport line 110 (bound line 110 a and return line 110 b), a loading module 120, a centrifuge module 130, an opening module 150, a labeler 160, and a dispensing module 170 as basic elements. A preprocessing system 100 including a plurality of modules, a storage unit 300 including a plurality of modules having the closure module 310, the classification module 320, and the storage module 330 as basic elements (the preprocessing system 100 and the storage unit 300 together The system 100 may also be comprised of a control unit 400 that controls the pretreatment system 100 and an automatic analyzer 200 that analyzes the components of the specimen. A serum information measurement unit 140 exists between the centrifugal separation module 130 and the opening module 150.

  First, the specimen is input from the input module 120 and conveyed to the centrifuge module 130. However, when a centrifugal process is unnecessary, such as a blood cell counter, the centrifugal module 130 is skipped and conveyed to the next process. Similarly, the centrifuge module 130 is skipped for the specimen that has been input to the input module 120 in a state where the centrifugation process has been executed in advance.

  The specimen that has been subjected to the centrifugal process is carried to the serum information measurement unit 140, and color information of the serum region is obtained from analysis of an image acquired by imaging with a color camera or the like, and the serum information is determined. The result is transmitted to the control unit 400 via the communication means 180. In the control unit 400, the processing workflow of the sample is determined according to an algorithm described later. In addition to the color camera, other detectors that can acquire the color information of the specimen may be used for acquiring the color information.

  Next, the specimen is transported to the opening module 150 and subjected to an opening process. When the subdivision process is necessary, the child sample container is prepared by the labeler 160, and the subdivision process is performed by the subsequent dispensing module 170. Then, according to the measurement plan which control unit 400 creates beforehand, it is conveyed to the specified automatic analyzer 200, and component analysis is performed.

A sample (parent sample) that has been processed by the pretreatment system 100, a child sample or parent sample that has been analyzed by the automatic analyzer 200, or a determination result of the serum information measurement unit 140 is determined not to be transported to the automatic analyzer 200. The sample thus obtained passes through the return line 110b and is conveyed to the storage unit 300. The plugging module 310 performs a plugging process as necessary, and the classification module 320 performs classification processing or the storage module 330 stores the processing.

  Next, a processing workflow in the preprocessing system 100 of the sample test automation system 1 will be described with reference to FIG. In FIG. 3, the path of the first analysis is indicated by a white arrow, and the path at the time of reinspection or additional inspection is indicated by a solid arrow.

  First, the samples 11 to 14 are thrown into the pretreatment system 100 by the user (path 41). The pretreatment system 100 includes a serum information measurement unit 140, and the samples 13 and 14 that cannot be analyzed by the subsequent automatic analysis system 200 are excluded from the analysis target (path 42), and the excluded samples are excluded. Is conveyed to the storage unit 300 as it is and stored (path 45). The samples 11 and 12 that can be analyzed are transported to the automatic analysis system 200 (path 43), and after the analysis is performed, they are transported to the storage unit 300 and stored (path 44).

  When re-analysis or additional analysis occurs, the workflow at the time of analysis is determined with reference to the serum information obtained at the previous measurement. For example, after being taken out from the storage unit 300, the path 51 is transported to the automatic analysis system 200 without passing through the serum information measurement unit 140, or is transported to the automatic analysis system 200 after passing through the serum information measurement unit 140. As a result of passing through the route 53 and the serum information measurement unit 140, there is a route 54 that is not conveyed to the automatic analysis system 200 but returned to the storage unit 300 again. A sample whose serum state may change while being stored in the storage unit 300 takes a route via the serum information measurement unit 140 during reanalysis.

  FIG. 3 is a diagram showing typical sample types that can be input to the system 100 according to an embodiment of the present invention. Here, the state of a specimen (particularly a blood specimen) that has already been centrifuged is shown, but the specimen that is actually put into the system may be the specimen before the centrifugation. In that case, the components of the specimen are not separated and the whole blood specimen is input.

  A separating agent 22 is placed in the container 21 in advance, and blood is separated into three layers of serum, separating agent, and blood clot when subjected to centrifugation after blood collection. Note that there is no separating agent for items that use plasma samples for component analysis. Among these, the serum is classified into several types according to the state, and the typical ones are the normal serum 31, the low hemolytic serum 32, the high hemolytic serum 33, and the chyle serum 34. Each feature will be explained briefly.

  FIG. 3A shows the state of normal serum 31. The normal serum 31 is serum in a state in which component analysis can be performed as it is by the automatic analyzer 200.

  FIG. 3 (b) is a diagram showing the state of the low hemolytic serum 32. The low hemolytic serum 32 is a state in which blood hemoglobin is partially destroyed and is generally thin and reddish. However, depending on the item, the low hemolytic serum 32 is in a state where component analysis can be performed by the automatic analyzer 200. It is.

  FIG. 3 (c) is a diagram showing the state of the highly hemolyzed serum 33. The highly hemolyzed serum 33 is generally reddish in a state seen when blood hemoglobin is destroyed, and has a large influence on the result of component analysis. Therefore, component analysis is generally avoided. Also in the present invention, the highly hemolyzed serum 33 is not flowed to the automatic analyzer 200 as it is.

  FIG. 3 (d) is a diagram showing the state of chyle serum 34. The chyle serum 34 is turbid serum due to the influence of lipids and the like, and when the degree of turbidity is strong, the component analysis by the automatic analyzer 200 is assumed to be avoided.

  Next, a sample workflow will be described with reference to a flowchart. FIG. 4 is a flowchart for explaining a method of determining a sample workflow according to an embodiment of the present invention.

  When the specimen is put into the pretreatment system 1 (S1), the specimen is transported to the serum information measurement unit 140 after being subjected to a centrifugal separation process as necessary. The serum information measurement unit 140 is equipped with a detector capable of acquiring serum color information, such as a camera capable of color photography (for example, a CCD camera). The appearance of the sample container 21 is photographed, the acquired image is analyzed, a serum area is specified, and color information acquisition processing A for acquiring color information of the serum area is executed (S2). The determination result is recorded in a recording device inside the control unit 400.

  Next, the serum state of the specimen is determined based on the color information (S3). When the determination result is the normal serum 31 or the low hemolytic serum 32, since the analysis by the automatic analyzer 200 can be executed, control is performed so that the pretreatment is continued and then conveyed to the automatic analyzer 200 (S4). After the predetermined analysis is executed by the automatic analyzer 200, the sample is stored in a predetermined storage location (S6).

  On the other hand, the serum determined not to be normal or low hemolytic serum in S3 may be high hemolytic serum 33 or chyle serum 34. Such a sample is output to an alarm without being transferred to the automatic analyzer 200 (S5), and then temporarily stored in the storage unit (S6).

  When a request for reanalysis or additional analysis is generated for a stored sample (S7), the control target 400 controls the sample to be requested automatically from the storage unit 300. The control unit 400 refers to the color information or serum status information of the specimen acquired at the time of the previous analysis and recorded in the recording device, and determines a processing workflow based on the information (S8).

  The sample determined to be a normal sample at the time of the previous analysis is assumed to have no abnormality even at the time of retesting, and is thus transported to the automatic analyzer 200 as it is without stopping at the serum information measurement unit 140 (S9).

  The specimen (S10) determined to have low hemolysis and chyle serum at the time of the previous analysis and the specimen (S11) determined to be low hemolytic serum are transported to the serum information measurement unit 140, and the color information is again obtained. The color information acquisition B to be acquired is executed (S14), and the serum state is determined. As a result of the re-determination, if the hemolysis of the sample has progressed and transitioned to a highly hemolyzed state (“Yes” in S15), since the re-analysis is not appropriate, the sample is not transported to the automatic analyzer 200. Is output to the storage unit 300 (S19). On the other hand, as a result of redetermination, if it is determined that hemolysis has not progressed and the hemolysis state still remains low (“No” in S15), the specimen is transported to the automatic analyzer 200 and analysis is performed. (S9) After the analysis is completed, it is stored in the storage unit (S17).

For the sample (S12) determined to be a chyle sample at the time of the previous analysis, it is determined whether the elapsed time from the previous acquisition of color information has reached a predetermined threshold (S13). The threshold value here is a value registered in advance in the control means 400, and more preferably it can be changed by the user. If a certain amount of time has elapsed, the lipid component may precipitate and the sample may be free from turbidity. Therefore, when a retest is requested, drop the sample into the serum information measurement unit and check the color information. Is obtained again (S14), and the serum state is determined. If it is confirmed by re-determination that chyle has been eliminated (“No” in S15), the analysis can be performed by the automatic analyzer 200, so that the chyle is conveyed to the automatic analyzer 200 (S9). On the other hand, if the chyle is still not resolved as a result of the remeasurement, or if a predetermined time has not elapsed since the previous measurement, the system outputs an alarm (S16), and the sample is sent to the automatic analyzer 200. It is stored in the storage unit 300 without being conveyed (S17).
According to this workflow, only samples that require reconfirmation of the color state of the serum at the time of reexamination are stopped at the serum information measurement unit 140, and reexamination is performed by preventing samples that do not need to be reconfirmed. Sometimes, the total number of specimens that stop at the serum information measurement unit 140 can be reduced, and it is possible to avoid delays in measurement results due to congestion in the system.

  Further, even if a sample that was in a low hemolysis state at the time of the initial analysis has changed to a high hemolysis state over time, it can be determined before the reanalysis is performed, thereby avoiding unnecessary consumption of reagents.

  In addition, even if the sample is determined to have a chyle state at the time of the previous analysis, the response at the time of reanalysis can be switched automatically and appropriately, and the user's visual confirmation and manual input work are not required.

  FIG. 5 is a diagram illustrating an example of a threshold setting screen. The configuration of this screen is a representative example, and the embodiment is not limited in details such as button arrangement.

  The threshold setting screen 60 has a function for setting a threshold for determining a hemolytic state and a function for setting a threshold for determining a chyle state. For setting the threshold value for hemolysis, a bar 61 indicating color information of serum and knobs 63 and 64 are used. It is visually desirable that the bar 61 is based on red. The user can use the knobs 63 and 64 to set an appropriate threshold value. For example, by moving the knob 63 in the direction of the arrow 66a, a threshold value for discriminating between low hemolytic serum and normal serum can be set. Further, if the knob 64 is moved in the direction of the arrow 66b, a threshold value for distinguishing between low hemolytic serum and high hemolytic serum can be set.

  Similarly, a bar 62 indicating serum color information and a knob 65 are used for setting the threshold value of chyle serum. It is visually preferred that the bar 62 uses a color based on white. The user sets threshold values for normal serum and chyle serum by moving the knob 65 in the direction of the arrow 66c.

  The set content is incorporated as a parameter in the control unit 400 when the OK button 67 is pressed, and is reflected in the determination of the next sample.

  By providing the setting screen, it is possible to optimally set and change the threshold value for distinguishing between normal serum, low hemolytic serum, high hemolytic serum, and chyle serum for each apparatus. The boundary between normal and low hemolysis is a boundary that determines whether or not to drop to the serum information measurement unit 140 at the time of reanalysis, and is a parameter that affects the congestion of the specimen.

  When the serum information is obtained from the absorbance by the automatic analyzer 200, the serum color information obtained by the serum information measurement unit 140 is compared with the serum information obtained by the automatic analyzer, and the comparison result is obtained. Based on this, a function for recommending a more accurate threshold may be provided. In this case, it is possible to set a threshold value that can accurately determine a low hemolyzed sample and a normal sample, and an effect of optimizing the number of samples that stop at the serum information measurement unit 140 during reanalysis can be expected.

  FIG. 6 is a diagram illustrating an example of a screen for switching and setting a workflow for acquiring serum information during reanalysis. Note that the configuration of this screen is a representative example, and the embodiment is not limited in detail such as button arrangement / description.

  The switching screen 70 is provided with a “stop all samples at the time of reanalysis” button 71 and a “stop automatic switching” button 72. When the “stop all samples at the time of reanalysis” button 71 is pressed, a workflow in which serum information is always remeasured for all the samples is adopted at the second and subsequent reanalysis. On the other hand, when the “stop and stop automatic switching” button 72 is pressed, a workflow for automatically determining whether to re-measure serum information at the time of reanalysis is adopted. The set content is incorporated as a parameter in the control unit 400 when the OK button 67 is pressed, and is reflected from the next sample processing.

By providing this screen, workflows can be switched according to user settings, and the versatility of the system is improved.

  Next, another embodiment according to the present invention will be described. This embodiment is a particularly effective method for the chyle specimen 34.

  First, the concept of the sample processing workflow in this embodiment will be described with reference to FIG. FIG. 7 is a schematic diagram for explaining the concept of a sample workflow according to another embodiment of the present invention. As in FIG. 3, the path at the first insertion is indicated by a white arrow, and the transport path after removal from the storage portion is indicated by a solid line arrow.

  The user inputs the sample 14 into the system (path 41). First, the sample is transported to the serum information measurement unit 140 in the pretreatment system 100, and when it is determined that the sample is the chyle sample 14, the sample is not transported to the automatic analyzer 200 (path 42). It is temporarily stored in the storage unit 300 (path 45).

  When a reanalysis request is generated for this sample, the stored sample is automatically taken out of the storage unit 300 under the control of the control unit 400 and re-transported to the pretreatment system 100 (path 54). In the present embodiment, the pretreatment system 100 includes a reagent addition mechanism 190 that adds a reagent for eliminating chyle (for example, a surfactant) to a specimen. After a reagent for eliminating chyle is added to the transported chyle sample, the specimen 14b from which chyle is eliminated is re-transported to the automatic analyzer 200 (path 55), and after the analysis, the storage unit 300 is again provided. (Path 56) for storage.

  FIG. 8 is a plan view of a dispensing module including a reagent addition mechanism 190 according to another embodiment of the present invention, and FIG. 9 is a front view of the reagent addition mechanism according to another embodiment of the present invention.

  The dispensing module 170 has a chip 172, a magazine 171 for collectively setting the chips, a dispensing mechanism 190 (specimen aspirating and discharging function, and a function for dispensing a chyle eliminating reagent described later). Desirably) X-axis 173 and Y-axis 174 for moving the dispensing mechanism 190, motor 175 for controlling the X-axis and Y-axis, tip removal jig 178, tip disposal hole 179, vertical movement of the dispensing mechanism 190 Arm 193 for performing the above, a motor 192 for moving the arm, and the like.

  First, the operation when the dispensing mechanism performs normal subdivision dispensing will be described.

  The parent sample (blood sample) arrives at the parent sample dispensing position 176 via the transport line, and the subdivided container (child sample container) arrives at the child sample dispensing position 177 from the labeler via the transport line. Then, first, the control unit 400 moves the X axis and the Y axis by a predetermined distance by controlling the number of steps of the motor 175 so that the dispensing mechanism 190 stops at the position of the chip 172 in the magazine 171. Thereafter, the motor 192 is driven, the arm 193 is moved to lower the dispensing mechanism 190 in the vertical direction, and the tip 172 is attached to the tip of the nozzle 194 by the pressure when the dispensing mechanism 190 is lowered. A state where the tip 172 is attached to the tip of the nozzle 194 is shown in FIG.

  Next, the control unit 400 moves the dispensing mechanism 190 to the parent sample dispensing position 176, positions the dispensing mechanism 190 directly above the parent sample container, and then lowers the tip 172 to immerse the tip of the tip 172 in the parent sample. The sample is aspirated. The aspirated sample is discharged into the child sample container positioned at the child sample dispensing position 177.

  Thereafter, the control unit 400 moves the dispensing mechanism 190 to the upper part of the chip removal jig 178. The chip removal jig 178 has an edge portion that is engaged with the flange 172 a at the upper end of the chip. By hooking the flange 172 a on the edge 178 a of the chip removal jig 178, the chip 172 is removed from the nozzle 194 and the disposal hole 179 is disposed. Dispose of.

  FIG. 10 is a flowchart showing a sample workflow when the dispensing mechanism has a function of adding a chyle elimination reagent.

  Steps 1 to 17 (S1 to S17) are the same as those in FIG. Another two steps (T1, T2) added are the parts according to the present embodiment.

  The specimen (S12) determined to be a chyle specimen at the time of the previous analysis acquires the serum color information again if the elapsed time since the previous color information acquisition has reached a predetermined time (S13). (S14). As a result of the determination in S14, when the chyle has not been eliminated (T1), the sample is transported to the dispensing module 170. If the sample is in a closed state, the stopper may be stopped on the way to the plugging module 150 halfway. Since the presence or absence of the stopper is managed by the control unit 400, the control unit 400 determines whether or not to stop by the opening module 150.

  The sample arriving at the dispensing module 170 is transported to the dispensing position 176. The dispensing mechanism 190 performs the same control as the above-described subdivision dispensing operation, and attaches the tip 172 to the tip of the nozzle 194 of the dispensing mechanism 190. After the tip 172 is mounted, the dispensing mechanism 190 is moved above the position where the chyle elimination reagent 191 is installed, and the elimination reagent 191 is aspirated. Note that the elimination reagent 191 may be stored in a dedicated container and installed, or a filling hole may be prepared and injected beforehand.

  The aspirated elimination reagent 191 is added to the specimen (T2). The elimination reagent may be discharged directly into the parent sample container, or it may be discharged into the subdividing container to carry out chyle elimination processing in the subdividing container. Thereafter, the sample mixed with the elimination reagent is transported to the automatic analyzer 200 and component analysis is performed. By adding the reagent 191, it can be expected that component analysis is performed in a state where chyle is eliminated.

  The process according to the present embodiment is also applicable when the previous determination result is chyle and a predetermined time has not elapsed (S13). Even if there is a possibility that chyle has not been sufficiently eliminated, it is particularly effective in an urgent situation to be able to proceed with component analysis by adding the elimination reagent 191.

The module for installing the mechanism 190 is not limited to the dispensing module 170. As another embodiment of the system, for example, a method of providing in the opening module 150 is also conceivable. Further, in the case of a system that does not include the capping module 310, or when it is operated under the condition that the capping is not made uniform in the case of temporary storage, the structure 190 may be installed in the serum information measurement unit 140 itself.

1 Specimen Automation System 11-14 Specimen 21 Container 22 Separating Agent 31 Normal Serum 32 Low Hemolyzed Serum 33 High Hemolyzed Serum 34 Whey Serum 35 Clot 60 Threshold Setting Screen 61 Bar 62 that Shows the Level of Hemolysis Bar 63 to 65 Knob 66 Arrow 67 OK button 70 Switching screen 71 “Stopping all samples uniformly during reanalysis” button 72 “Stopping automatic switching” button 73 OK button 100 Pretreatment system 110a Outbound line 110b Return line 120 Input module 130 Centrifugation Module 140 Serum information measurement unit 150 Opening module 160 Labeler 170 Dispensing module 171 Chip magazine (rack)
172 Chip 173 X-axis 174 Y-axis 175 Motor 176 Parent sample dispensing position 177 Child sample dispensing position 178 Chip removal jig 179 Chip disposal hole 190 Reagent addition mechanism (usually dispensing mechanism)
191 Dissolving reagent 192 Motor 193 Arm 194 Nozzle 200 Automatic analyzer 300 Storage unit 310 Closure module 320 Classification module 330 Storage module 400 Control unit

Claims (11)

A color information acquisition device for acquiring color information from a specimen derived from a living organism;
A storage device for storing the specimen;
A control device for controlling the sample transport path is provided.
The controller is
A sample state determination unit that determines a sample state based on the acquired color information;
A storage unit that stores information used to determine a workflow in an initial analysis regarding the acquired color information or the specimen state; and
When a request for reanalysis or additional analysis is generated for the sample stored in the storage device, whether or not to allow the color information acquisition unit to stop the sample based on the information stored in the storage device. A specimen test automation system having a determination unit for determining an included workflow. The specimen test automation system according to claim 1,
The specimen includes serum;
The sample state automation unit determines whether the sample state determination unit corresponds to normal serum, hemolyzed serum, or chyle serum. The specimen test automation system according to claim 2,
Wherein the control device, the specimen in which the request has occurred, if it was determined that the low hemolysis serum by already the specimen state determining unit determines the workflow to convey to the color information acquiring unit, specimen test automation system. The specimen test automation system according to claim 2,
Wherein the control device, the specimen in which the request has occurred, if it was determined to chyle serum by already the specimen state determination unit, based on the time the sample is held in the holding device, the workflow Determine the specimen test automation system. The specimen test automation system according to claim 1,
Wherein the control unit, the said request to the samples which are held in the holding device is generated, when the specimen was stop over on the color information acquiring unit, the request based on the acquired color information A specimen test automation system that determines whether or not to execute. The specimen test automation system according to claim 1,
A sample test automation system further comprising setting means for setting a determination criterion of the sample state determination unit. The specimen test automation system according to claim 1,
A specimen test automation system, further comprising setting means for disabling the specimen state determination unit. The specimen test automation system according to claim 2,
A specimen test automation system further comprising a mechanism for adding a reagent for removing chyle. A color information acquisition device that acquires color information from a biological sample, and a control device that controls a system including a storage device that stores the sample,
The controller is
A function of determining the specimen state based on the acquired color information; and
When a request for re-analysis or additional analysis occurs for a sample stored in the storage device, based on information used to determine a workflow in an initial analysis regarding the color information or the sample state A control device having a function of determining a workflow including whether or not to cause the color information acquisition unit to stop before executing the request . A control device according to claim 9, comprising:
The specimen includes serum;
The control device has a function of determining whether the control device is normal serum, hemolyzed serum, or chyle serum. Obtaining color information of the input specimen;
Determining the state of the specimen based on the color information;
When an additional analysis request is generated for the sample, an additional analysis is performed on the sample based on information used to determine a workflow in an initial analysis regarding the color information or the state of the sample And a step of determining whether or not to execute the step of acquiring color information again before.