JP6501485B2 - Sealed stopper which hollow needle can penetrate and container provided with the sealed stopper - Google Patents

Description

  The present invention relates to a sealing plug through which a hollow needle can penetrate and a container provided with the sealing plug so that the hollow needle can be penetrated to take out the contents of the container.

  Conventionally, a hollow needle such as an injection needle is penetrated through a sealing stopper of a container, and liquid is put in and out of the container through the hollow needle, for example, a container for sterile liquid medium, a vial for pharmaceuticals, an ink cartridge for printer, etc. It is performed in various containers (patent documents 1-6). When a hollow needle is pierced into a sealing stopper of a rubber material or a resin material, there arises a problem that rubber or resin scraped off by the hollow needle is mixed in the liquid in the container (Patent Documents 1 and 2).

  Also, in the case of a container used for a sterility test liquid medium (for example, Steritest (trademark) (Millipore Corporation)), etc., a hollow needle for drawing in by a pump and taking out the liquid medium It is necessary to simultaneously pierce the sealing plug with two hollow needles with a hollow needle in order to prevent it becoming dull, and the durability which can penetrate a plurality of hollow needles is called for.

JP, 2009-196666, A JP, 2009-234659, A JP 2001-114339 A Unexamined-Japanese-Patent No. 6-169971 Unexamined-Japanese-Patent No. 11-332956 JP, 2013-107692, A

  An object of the present invention is to provide a sealing plug capable of solving problems such as contamination and needle hole clogging when taking out contents of a container by penetrating a hollow needle and a container provided with the sealing plug. .

  As far as the present inventor is aware, in the relevant technical field, no material property has been studied so far for the purpose of avoiding the above-mentioned problems such as contamination and needle hole clogging. Under these circumstances, the inventor focused on the low shear property of the material while continuing intensive research to solve such problems and to provide a higher performance and more usable container sealing stopper. Furthermore, by using a non-shearing material as the material of the sealing plug used by inserting a hollow needle, it was found that the problem of contamination and the problem of needle hole clogging did not occur, and further research was advanced As a result, the present invention has been completed.

That is, the present invention relates to the following.
[1] The sealing plug having a piercing portion through which a hollow needle can penetrate, wherein the piercing portion is made of a material which is difficult to shear.
[2] The sealing plug according to the above [1], wherein the low shear material is linear low density polyethylene (LLDPE).
[3] A sealing plug for sealing a container comprising a container body and an opening, comprising a top plate including a piercing portion and a side wall portion depending from the top plate, the side wall portion being at the opening of the container The sealing plug according to the above [1] or [2], which seals the container by screwing or fitting.
[4] The sealing plug according to any one of the above [1] to [3], which is integrally molded.
[5] The sealing plug according to any one of the above [1] to [4], further comprising an inner lid on the inside of which the hollow needle can penetrate.
[6] The sealing plug according to the above [5], wherein the outer surface of the top plate is flat, the inner surface has a recess serving as a piercing portion, and a gap is provided between the top plate and the inner lid.
[7] The sealing plug according to the above-mentioned [6], wherein the thickness of the piercing portion is 0.1 to 1.5 mm.
[8] The sealing plug according to the above [7], wherein the width of the air gap is 0.3 to 4.5 mm.
[9] A container sealed in a fluid-tight and / or airtight manner by the sealing plug according to any one of the above [1] to [8].
[10] The container according to the above [9], which is for a sterile liquid medium.
[11] The container according to the above [9] or [10], which is made of resin.

  By making the piercing part of the sealing plug out of a low shear material, the material is scraped off and divided by the hollow needle penetrating the piercing part and fragments are not generated, so foreign matter in the contents of the container ( There is no contamination of the sealing plug) and no clogging of the hollow needle needle holes. By using a material having a low shear property and an appropriate stretchability, it is possible to more effectively prevent contamination and needle hole clogging.

  Furthermore, when an inner lid (plate-like packing or the like) is provided inside the sealing plug, liquid leakage can be effectively prevented when the container is displaced or the like. By providing an air gap between the piercing part of the sealing plug and the inner lid, it is possible to prevent the interference with the inner lid when the hollow needle penetrates the sealing plug.

FIG. 1 is a photographic view showing an embodiment of the sealing plug of the present invention. FIG. 2 is a schematic view showing a central cross section of the sealing plug of the present invention. FIG. 3 is a photographic view showing a state in which a hollow needle penetrates the sealing plug of the present invention. FIG. 4 is a photographic view showing a state after inserting and removing the hollow needle in the sealing plug of the present invention.

  The sealing plug of the present invention has a piercing portion made of a low shear material which can be pierced by a hollow needle. The low shear material which can be used for the sealing plug of the present invention can penetrate the needle tip when the hollow needle is pierced, but the shear property is poor, such as punching around the needle hole. It is a material which is not broken and the material scraped by the hollow needle is not broken.

  The low shear material is not particularly limited as long as it has low shear property, but linear low density polyethylene (LLDPE), ethylene / vinyl acetate copolymer (EVA), polyvinyl alcohol (PVA), polyurethane (PU), nylon (PA) is mentioned. Linear low density polyethylene (LLDPE) is mentioned as a suitable thing from a viewpoint that it has moderate stretchability in addition to low shear property. Linear low density polyethylene (LLDPE) can typically use different densities of LLDPE, such as C4, C6, C8, metallocene PE.

  The sealing plug of the present invention is typically shaped to correspond to the shape of the opening of the container to be sealed, and has a top plate including the piercing portion and a side wall portion depending from the top plate, the side wall The container seals the container by screwing or fitting into the opening of the container. The sealing plug may be any material having a low shear resistance, and the piercing part into which the hollow needle is pierced is typically provided with the piercing part in the center of the top plate. The sealing plug of the present invention is not necessarily required to be used in combination of a plurality of members, and can be manufactured by integral molding. By integrally molding in this manner, it is possible to simply discard the members without separating and discarding a plurality of members of different materials.

  In one aspect, the sealing plug of the present invention may be provided with an inner lid such as a plate-like packing inside the top plate. The inner lid can be held by the sealing stopper with an adhesive or the like, but can be held, for example, by a small convex portion inside the side wall of the sealing stopper without using an adhesive or the like. In consideration of workability and interference with penetration, when a plate-like packing is used as the inner lid, it is preferable to use a convex portion on the inner side wall without using an adhesive or the like.

  As the inner lid, a plate-like packing may be selected from the viewpoint of liquid-tight and / or airtight sealing. The hollow packing can penetrate the plate-like packing. The material of the packing is not particularly limited, but rubber materials such as silicone rubber, isoprene rubber, butyl rubber, and general elastomers can be used, and in particular, adhesion to the mouth of the container, sealing at the time of piercing, air tightness It is preferable to use silicone rubber from the viewpoint of securing the properties and liquid tightness. When the inner lid is formed of the same material as the sealing plug such as, for example, linear low density polyethylene (LLDPE), the entire sealing plug can be integrally molded.

  In one aspect, the sealing plug of the present invention can be typically made thinner at the central portion of the top plate than the other portions, and such thin portion can be used as a piercing portion. For the purpose of piercing the hollow needle, it is not necessary to be at the central portion of the top plate, and a plurality of such may be provided. The thin-walled part is a mode in which both the inner and outer sides of the top plate are recessed, the outer surface of the top plate is flat, and the inner surface is recessed, the inner surface of the top is flat and the outer surface is recessed It can form by any of the aspect which becomes. Among them, an embodiment is preferable in which the outer surface of the top plate is flat, and the inner surface has a recess serving as a piercing portion. By setting it as this aspect, an air gap can be provided between a top plate and an inner lid. In order to secure such a gap, it is also possible to provide a convex portion on the top plate.

  The hollow needle which can be penetrated to the sealing stopper of this invention will not be specifically limited if it is a generally used injection needle (syringe needle). The thickness of the hollow needle is typically 0.5 to 2.0 mm, preferably 1.0 to 1.7 mm.

  The thickness of the piercing portion can be appropriately adjusted according to the type of the low shear material, but, for example, in the case of using LLDPE, it is 0.1 to 10 in view of the punctility of the hollow needle. It is preferable that it is 1.5 mm and it is preferable that it is 0.3-1.0 mm, when providing a suitable space | gap with an inner lid | cover, the retention strength of the hollow needle which pierced, stretchability, etc. are considered.

  When there is no space between the top plate and the inner lid, when the hollow needle is pierced, the inner lid is pushed out and the inner lid is detached, the needle is less likely to be pierced, or the inner lid interferes with the top plate There is a risk that the material of the material and the material of the inner lid may get stuck in the needle hole, but by providing a space, the material escapes from the needle tip even when the material of the top plate is stretched when the hollow needle is pierced in the piercing part. A space is secured, and the material of the top plate is less likely to be clogged in the needle holes of the hollow needle. However, if a flexible rubber material is used for the inner lid and the inner lid is free to move and does not interfere, it is not necessary to provide a gap.

  The width of the space between the top plate and the inner lid is not particularly limited as long as the material allows the material to escape from the needle tip. For example, the material of the top plate of the sealing plug is LLDPE, and When the thickness of the through part is 0.1 to 1.5 mm, it is about 0.3 to 4.5 mm, and when the thickness is about 0.5 mm, it may be about 1.5 mm, It is preferable that the width of the space about three times the thickness of the piercing portion be secured.

  In addition, the thickness of the inner lid can be appropriately adjusted according to the type of the material of the inner lid, but adhesion with the mouth of the container, sealing at the time of needle stabbing, securing of air tightness, hollow needle From the viewpoint of the holding power and the ease of piercing the needle, etc., it is preferably 0.1 to 3.0 mm, more preferably 0.5 to 2.0 mm.

  The closure of the present invention allows the container to be sealed in a fluid and / or air tight manner. The use of the container sealed in this way is not particularly limited as long as it is a container in which a hollow needle such as an injection needle penetrates a sealing stopper of the container and the liquid is put in and out of the container through the hollow needle. The container provided with the sealing stopper of the present invention can be used, for example, as a container for liquid culture medium, a vial for medicine, an ink cartridge for printer, and the like. The container of the present invention is particularly excellent when used as a container for liquid culture medium. That is, in the container of the present invention, the hollow needle does not fall off even when the container is inverted or pressure is applied from the inside of the container, and the sealing plug and the inner lid (plate packing etc.) It is held.

  The container of the present invention is not particularly limited as long as the container body is deformable, sealed, and has a certain degree of shape retention, but polyethylene (PE), nylon (PA), polyethylene terephthalate (PET), polypropylene ( It is preferable to use a single-layer or multi-layer resin such as PP) or aluminum. By using a resin material or the like for the container, the possibility of breakage is reduced compared to glass, and the weight can be reduced, so that the operability is improved. Furthermore, since the buffer is basically unnecessary when storing or transporting, handling becomes easy. Further, since the sealing plug of the present invention is made of resin without using metal, by making the container main body made of resin, the burden of sorting is eliminated when discarding.

  Generally, when using a liquid medium in a glass container, a pipe for liquid transfer and a pipe for adjusting the pressure to which the filter is attached are attached, and the liquid medium is transferred using a suction pump. According to the container made of resin material, since the container is deformable, it is not necessary to attach a tube for adjusting the pressure, and if there is only a tube for liquid transfer, the liquid medium is transferred only by the suction pump be able to. Therefore, according to such an aspect, the container of the present invention can perform transfer of liquid culture medium by a simple mechanism without using a special tube. In addition, when the liquid culture medium is transferred, the inside of the container is basically decompressed because it is transferred by the suction pump as described above. Therefore, the needle stuck in the sealing stopper does not easily come out during the transfer of the liquid medium.

  When a resin material is used for the container, the liquid culture medium can be pumped by crushing the container without using a suction pump, but by pumping it may be released by a normal sealing stopper having weak holding force of the needle. Is high. However, the present invention uses a non-shearing sealing stopper and a highly adhesive inner lid, and since the holding power of the needle is higher than that of a material used for a normal sealing stopper, the sealing stopper can be used even by pumping. The needle does not come off easily. Therefore, by using the container and the sealing plug of the present invention, liquid transfer becomes possible without using a special pipe or a suction pump, so that the operability is improved and the cost is largely reduced. In addition, the need for sorting is eliminated at the time of disposal, which saves time and effort.

  Hereinafter, the present invention will be described in more detail based on the drawings, but the present invention is not limited to these embodiments, and various modifications can be made without departing from the technical concept of the present invention. It is.

  FIG. 1 shows an embodiment of the sealing plug 1 of the present invention. The sealing plug 1 has a top plate 3 having a thin thin-walled piercing portion 2 (a whitened portion in FIG. 1) which can be easily pierced with a hollow needle, and a side wall portion hanging down cylindrically from the top plate 3 4 is provided. The inner side of the side wall portion 4 has a structure that can be screwed or fitted to the opening of the container.

  FIG. 2 is a view showing a central cross section of the sealing plug 1 of the present invention shown in FIG. An inner lid 5 is provided inside the sealing plug 1. The inner lid 5 is held by the convex portion 6 provided on the side wall portion 4. The top 3 has a flat outer surface, and the inner surface has a recess, and the recess is a piercing portion 2. An air gap 7 is present between the inner surface of the piercing portion 2 and the upper surface of the inner lid 5. The air gap 7 is a space where the material escapes from the needle tip even when the material of the top plate 3 is stretched when the hollow needle pierces the piercing portion 2. This prevents the material of the top plate 3 from being clogged with the hollow needle.

<Puncture test>
(1) Production of sealed stopper Linear low density polyethylene (LLDPE) (Product No .: 20100J, manufactured by Prime Polymer Co., Ltd.) and the shape of the sealed stopper (thickness of piercing part: 0.5 mm, thickness of top plate: 2) The sealing stopper of the present invention was manufactured.

(2) Penetration of hollow needle The hollow needle was made to penetrate the sealing stopper manufactured by said (1) (FIG. 3). Although the LLDPE resin was scraped off the needle in response to the penetration of the needle, it did not clog in the needle hole nor fragmented from the top plate into fragments. Such a state was reproduced even if the vent needle was inserted and removed a plurality of times (FIG. 4, in the same drawing, the needle was inserted and removed in three places).

DESCRIPTION OF SYMBOLS 1 Sealing stopper 2 Piercing part 3 Top plate 4 Side wall part 5 Inner lid 6 Convex part 7 Gap

Claims (7)

A sealing stopper having a piercing portion through which a hollow needle can penetrate, having a top plate including the piercing portion, the piercing portion being linear low density polyethylene (LLDPE), an ethylene-vinyl acetate copolymer ( EVA), polyvinyl alcohol (PVA), polyurethane (PU) and nylon (PA) made of a material, and a plate-like silicone rubber inner lid which can be penetrated by a hollow needle inside the top plate and the inner lid A convex portion provided on the inner side of the side wall for holding, a flat outer surface of the top plate, a concave portion serving as a piercing portion on the inner surface, and a gap between the top plate and the inner lid Yes and is, the thickness of the piercing portion is 0.1 to 1.5 mm, the width of the gap is a 0.3～4.5Mm, the thickness of the inner lid 0.1-3. Said sealing stopper which is 0 mm .   The sealing plug according to claim 1, wherein the material of the piercing portion is linear low density polyethylene (LLDPE). A closure for sealing a container comprising a container body and an opening, comprising:
A top plate including a piercing portion and a side wall portion depending from the top plate,
The sealing plug according to claim 1 or 2, wherein the side wall part seals the container by screwing or fitting into the opening of the container.   The sealing plug according to any one of claims 1 to 3, which is integrally molded. A container sealed in a fluid-tight and / or airtight manner by the closure according to any one of claims 1 to 4 . The container according to claim 5 , which is for a sterile liquid medium. The container according to claim 5 or 6 , which is made of resin.