JP6503207B2 - Denture stabilizer - Google Patents

Description

  The present invention relates to, for example, a denture stabilizer which is used by being filled between an oral mucosa and a denture base of a denture.

  Conventionally, as this kind of denture stabilizer, denture stabilizer containing liquid paraffin, white petrolatum, a cellulose derivative, and a methoxyethylene maleic anhydride copolymer salt is known (patent document 1). .

  The denture stabilizer described in Patent Document 1 adheres to the denture base and the oral mucosa so as to fill the gap between the denture base and the oral mucosa, for example, in order to stabilize the position of the denture worn in the oral cavity. Let it be used.

  However, the denture stabilizer described in Patent Document 1 has a problem that the adhesive strength tends to decrease when it is repeatedly subjected to a load by chewing.

Japanese Patent Application Laid-Open No. 2003-093412

  An object of the present invention is to provide a denture stabilizer capable of suppressing a decrease in adhesive force even under repeated load.

The denture stabilizer according to the present invention comprises a vegetable oil as a liquid oil containing triglyceride, and a biogenic wax (but excluding soy lecithin) . Such a denture stabilizer can sufficiently suppress the decrease in adhesion even under repeated loading.

It is preferable that said denture stabilizer contains 25 mass% or more of said vegetable oil as said liquid oil, and contains 10 mass% or more of said biological origin wax .

In the above denture adhesive, it is preferred that the liquid oil is olive oil. Alternatively, it is preferable that the bio-based wax is beeswax (beeswax). The liquid oil being olive oil has the advantage of improving the safety of the denture stabilizer to the human body. The beeswax (beeswax) being a bio-based wax has the advantage of improving the safety of the denture stabilizer to the human body.

  It is preferable that the above-mentioned denture stabilizer further contains a carboxymethylcellulose salt. The denture stabilizer further includes a carboxymethylcellulose salt, which has an advantage that the feel of using the denture stabilizer on the oral mucosa is better.

  It is preferable that the above-mentioned denture stabilizer further contains at least one of water and a polyhydric alcohol. The denture fixative further includes at least one of water and a polyhydric alcohol, which has an advantage that the feeling of using the denture fixative on the oral mucosa becomes better.

  The denture stabilizer of the present invention exhibits the effect of being able to suppress the decrease in adhesive strength even under repeated loading.

Schematic showing the test equipment for a repeated load test. The graph showing the adhesive force of each Example. The graph showing the adhesive force of each Example. The graph showing the adhesive force of a product and each example. The graph showing the adhesive force after the repetition load of each Example. The graph showing the adhesive force after the repetition load of each Example. The graph showing the adhesive force after the repetition load of each Example. The graph showing the adhesive force of each Example. Graph showing adhesion of product. The graph showing the adhesive force after the repetition load of each Example. The graph showing the adhesive force after the repetition load of each Example. The graph showing the adhesive force after the repetition load of each Example. The graph showing the adhesive force of each Example. The graph showing the adhesive force of each Example.

  Below, one embodiment of a denture stabilizer concerning the present invention is described.

  The denture stabilizer of the present embodiment includes at least a liquid oil containing triglyceride and a bio-based wax. The denture stabilizer of the present embodiment preferably further comprises a carboxymethylcellulose salt and at least one of water and a polyhydric alcohol.

  The denture stabilizer of the present embodiment is usually a viscous body. The denture stabilizer of the present embodiment is configured, for example, to be deformed by application of an external force at room temperature, and to maintain its shape as long as no external force is applied.

  The denture stabilizer is more easily deformed as the temperature rises. The denture stabilizer is configured to adhere to both the mucous membrane of the oral cavity and the denture base of the denture while maintaining the shape at 35 to 37 ° C. near the body temperature in the oral cavity.

  The liquid oil is one in which at least a portion flows out of the beaker within 5 seconds when the beaker is inclined 90 degrees at 20 ° C. from a state in which 50 mL is stored in a 100 mL beaker.

  Examples of the liquid oil include vegetable oil and synthetic oil.

Examples of the vegetable oil include olive oil, palm oil, soybean oil, rapeseed oil, sunflower oil, palm kernel oil, cotton seed oil, peanut oil, coconut oil, coconut oil, corn oil, sesame oil, castor oil, linseed oil, macadamia nut oil, jojoba seed oil, avocado Oil, apricot kernel oil, kucunut oil, grape seed oil, safflower oil, sweet almond oil, corn germ oil, hazelnut oil, meadow home oil, rosehip oil, cranberry vicinica oil, etc. may be mentioned.
Examples of the synthetic oil include tri-2-ethylhexanoic acid glyceride and the like.

  As the liquid oil, olive oil is preferable in that the safety of the denture stabilizer to the human body is better. Olive oil is a liquid oil obtained from olive fruits.

  The liquid oil preferably contains at least 80% by mass of triglyceride. The liquid oil contains, for example, fatty acids, glycerin and the like in addition to triglycerides.

  The triglyceride is a compound in which three fatty acids are ester-linked to one glycerin.

  The fatty acid residue constituting the triglyceride is usually a carboxylic acid residue having 8 to 20 carbon atoms. As a fatty acid residue, a saturated fatty acid residue or an unsaturated fatty acid residue is mentioned.

Examples of the saturated fatty acid residue include caprylic acid residue, capric acid residue, lauric acid residue, myristic acid residue, palmitic acid residue, stearic acid residue and the like.
Examples of the unsaturated fatty acid residue include oleic acid residue, linoleic acid residue and linolenic acid residue.

  The triglyceride is preferably a triglyceride formed by bonding at least one unsaturated fatty acid to glycerin, and more preferably a triglyceride formed by bonding at least one oleic acid to glycerin. There is an advantage that the fluidity of the liquid oil can be more reliably maintained because the triglyceride is a triglyceride formed by bonding at least one unsaturated fatty acid to glycerin.

  As said liquid oil, what is marketed can be used, for example.

  The denture stabilizer of the present embodiment preferably contains 25% by mass to 80% by mass of the liquid oil, more preferably 30% by mass to 70% by mass, and further preferably 35% by mass to 50% by mass More preferable. By containing 25% by mass or more of liquid oil, there is an advantage that the denture stabilizing agent is less likely to feel pain when peeled from the oral mucosa. By containing the liquid oil at 80% by mass or less, there is an advantage that the shape retaining property of the denture fixative and the adhesion to the oral mucosa become more sufficient.

  The denture stabilizer of the present embodiment preferably contains only olive oil as a liquid oil. That is, the liquid oil is preferably only olive oil.

  The biological wax is a wax produced by an organism. The bio-based wax is a solid that does not flow at 20 ° C. Examples of the organisms include animals such as insects, and plants.

  The bio-based wax contains at least an ester compound of a higher fatty acid and a monohydric or dihydric higher alcohol. Examples of such an ester compound include myricyl palmitate, myricyl cerotate and the like.

  Examples of the bio-based waxes include animal waxes and vegetable waxes. Examples of the animal waxes include beeswax. Examples of the vegetable wax include carnauba wax, candelilla wax, mokurou (haiku), rice wax (rice bran) and the like.

  As the above-mentioned organism-derived wax, beeswax is preferable in that the safety of the denture stabilizer to human body becomes better, and white beeswax in which beeswax is bleached is more preferable. Beeswax is obtained from the wax component that is secreted from the bees wax secretory gland and attached to the honeycomb.

  As the above-mentioned organism-derived wax, for example, those commercially available can be used.

  The denture stabilizer of the present embodiment preferably contains 10% by mass to 50% by mass, and more preferably 15% by mass to 30% by mass of the biological origin wax. By containing 10% by mass or more of biological origin wax, there is an advantage that the shape retention property of the denture stabilizer and the adhesion to the oral mucosa become more sufficient, and by containing 50% by mass or less of biological origin wax, There is an advantage that the denture fixative is less likely to feel pain when it is removed from the oral mucosa.

  It is preferable that the denture stabilizer of this embodiment contains only beeswax as a biological origin wax. That is, it is preferable that the biological origin wax is only beeswax.

  In the denture stabilizer of the present embodiment, the mass ratio of liquid oil to biological origin wax is preferably liquid oil: biological origin wax = 1: 1 to 3: 1, and 1.5: 1 to 2.5. It is more preferable that Liquid oil: biological origin wax = 1: 1 to 3: 1, which makes it more difficult to feel pain when the denture fixative is peeled from the oral mucosa, and the shape retention property of the denture fixative and the oral mucosa There is an advantage that the adhesion to the electrode is more sufficient. In addition, there is an advantage that the adhesive strength can be more sufficiently suppressed from being lowered even if it is repeatedly subjected to a load due to wrinkles and the like. In the denture stabilizer of the present embodiment, the mass of the liquid oil is usually larger than the mass of the organism-derived wax.

  The denture stabilizer of the present embodiment can further improve the feeling of using the denture stabilizer on the oral mucosa by further including a carboxymethylcellulose salt.

  Examples of carboxymethylcellulose salts include sodium salts, potassium salts, ammonium salts and the like. As a carboxymethylcellulose salt, carboxymethylcellulose sodium salt is preferred. In addition, as a carboxymethylcellulose salt, what is marketed can be used.

  The denture stabilizer of the present embodiment preferably contains 1% by mass or more and 20% by mass or less, and more preferably 10% by mass or more and 20% by mass or less of a carboxymethylcellulose salt. By including 1% by mass or more and 20% by mass or less of the carboxymethylcellulose salt, it is possible to improve the feeling of using the denture fixative on the oral mucosa.

  In the denture stabilizer of the present embodiment, the mass ratio of liquid oil to carboxymethyl cellulose salt is preferably liquid oil: carboxymethyl cellulose salt = 1: 1 to 80: 1, and is 2: 1 to 3: 1. Is more preferred. Liquid oil: Carboxymethylcellulose salt = 1: 1 to 80: 1 makes it more difficult to feel pain when the denture fixative is peeled from the oral mucosa, and the shape retention property of the denture fixative and the oral mucosa There is an advantage that the adhesion to the electrode is more sufficient.

  In the denture stabilizer of the present embodiment, the weight ratio of the bio-based wax to the carboxymethyl cellulose salt is preferably bio-based wax: carboxymethyl cellulose salt = 1: 1 to 40: 1, and 1.0: 1 to 1. More preferably, it is .5: 1. Organo-derived wax: Carboxymethylcellulose salt = 1: 1 to 40: 1, which makes it more difficult to feel pain when the denture stabilizer is peeled from the oral mucosa, and the shape retention of the denture stabilizer and oral cavity There is an advantage that adhesion to the mucous membrane is more sufficient.

  The denture stabilizer of the present embodiment can further improve the feeling of using the denture stabilizer on the oral mucosa by further including at least one of water and a polyhydric alcohol.

  Polyhydric alcohol is an organic compound having a plurality of hydroxy groups in the molecule and is an organic compound which mixes with water at any rate at room temperature (20 ° C.).

  Examples of polyhydric alcohols include glycerin, ethylene glycol, propylene glycol, butylene glycol, pentylene glycol, diglycerin, dipropylene glycol and the like.

  The denture stabilizer of the present embodiment preferably further includes glycerin as a polyhydric alcohol. By further including glycerin, there is an advantage that the denture stabilizing agent is less likely to feel pain when it is peeled from the oral mucosa.

  The denture stabilizer of the present embodiment preferably contains 1% by mass to 40% by mass, and more preferably 15% by mass to 30% by mass of glycerin. By containing 1% by mass to 40% by mass of glycerin, there is an advantage that the shape retention property of the denture stabilizer and the adhesion to the oral mucosa become more sufficient.

  The denture stabilizer of the present embodiment preferably further comprises water. The additional inclusion of water has the advantage that the denture fixative is less likely to feel pain when it is removed from the oral mucosa.

  It is preferable that the denture stabilizer of this embodiment contains 1 mass% or more and 10 mass% or less of water. By containing water in an amount of 1% by mass or more and 10% by mass or less, there is an advantage that the shape retention property of the denture stabilizer and the adhesion to the oral mucosa become more sufficient.

  The denture stabilizer of the present embodiment preferably further comprises water and / or glycerin.

  The ratio of the mass of liquid oil contained in the denture stabilizer of the present embodiment to the total mass of glycerin and water is that the mass of liquid oil: the total mass of glycerin and water = 1: 1 to 2: 1 preferable. This has the advantage that the shape retention of the denture fixative and the adhesion to the oral mucosa will be more sufficient.

  The ratio of the weight of the biogenic wax contained in the denture stabilizer of the present embodiment to the total weight of glycerin and water is the weight of the biogenic wax: the total weight of glycerin and water = 0.5: 1 to 1.0 : 1 is preferable. This has the advantage that the shape retention of the denture fixative and the adhesion to the oral mucosa will be more sufficient.

  The ratio of the mass of carboxymethylcellulose salt contained in the denture stabilizer of the present embodiment to the total mass of glycerin and water is: mass of carboxymethylcellulose salt: total mass of glycerin and water = 0.1: 1 to 3: 1 Is preferably 0.5: 1 to 1.0: 1. This has the advantage that the shape retention of the denture fixative and the adhesion to the oral mucosa will be more sufficient.

  The denture stabilizer of the present embodiment may contain a fragrance, a pH buffer, a preservative, an antioxidant, and the like, in addition to the above-mentioned combination components.

  The denture stabilizer is manufactured by a general method. Specifically, for example, the liquid oil and the organism-derived wax are mixed while heating, and stirring is continued. Thereafter, a carboxymethyl cellulose salt previously swollen in glycerin or water is added to the mixture, and the mixture is further stirred to be cooled after the mixture becomes homogeneous. In this way, denture fixatives can be produced.

  The denture stabilizer is, for example, applied to a denture base of a denture, and then disposed and used in the oral cavity so as to be in contact with the oral mucosa.

  The denture stabilizer of the present embodiment can suppress the decrease in the adhesive strength even if it is repeatedly subjected to a load due to wrinkles and the like. In addition, when the denture fixative is peeled from the oral mucosa, it becomes less likely to feel pain. Moreover, since the denture stabilizer of this embodiment contains olive oil as a liquid oil and contains beeswax as a biological origin wax, the safety of the denture stabilizer to the human body is good. Moreover, since the denture stabilizer of this embodiment contains a carboxymethylcellulose salt, the feeling of use in the oral mucosa of a denture stabilizer is favorable. Moreover, since the denture retentive agent of this embodiment has sufficient shape retention and adhesiveness to an oral mucosa, it is hard to remove from an oral mucosa in an oral cavity.

  Although the denture stabilizer of this embodiment is as the above-mentioned illustration, this invention is not limited to the above-mentioned denture stabilizer. In the present invention, various forms adopted in a general denture stabilizer can be adopted as long as the effects of the present invention are not impaired.

  EXAMPLES The present invention will next be described in more detail by way of examples, which should not be construed as limiting the invention thereto.

The denture stabilizer of each test example was manufactured with the composition shown in Table 1. Details of each raw material are as follows.
(A) [liquid oil]
Olive oil (Japanese Pharmacopoeia)
・ Other liquid oil Liquid paraffin (B) [biologically derived wax]
(B-1) Mitsuro (product name "Code No. 03-0670-5" manufactured by Sigma Aldrich Japan)
(B-2) Sarashi bee wax (made by Japanese Pharmacopoeia Miki Chemical Industry Co., Ltd.)
(B-3) Carnauba wax (made by Yamakasa Sangyo Co., Ltd. for cosmetics)
(B-4) Hakurou (Lot. 1103080 Matsuba Pharmaceutical Co., Ltd.)
・ Other wax paraffin (C) [carboxymethylcellulose salt]
(C-1) Carboxymethylcellulose sodium salt (CMC-Na)
(Product name "Cerogen PM-250L" manufactured by Daiichi Kogyo Seiyaku Co., Ltd.)
(D) [Polyhydric alcohol] Glycerin (E) [Water] Purified water

Example 1
The liquid oil and wax shown in Table 1 were heated and stirred in a beaker placed in hot water of 80 ° C. or higher to dissolve until a uniform state was obtained. Thereafter, with stirring, the mixture was alternately placed in a room temperature environment and in ice water together with a beaker, and stirring was continued until the mixture solidified. The solidified mixture was left at room temperature for about 2 days. The mixture formed in the mixture after standing was crushed by a roller. In this way, a viscous denture stabilizer was produced.

(Examples 2 to 11)
A denture stabilizer was manufactured in the same manner as Example 1 except that each component was blended in the blending amounts shown in Table 1, respectively.

  The product shown below was used as a denture stabilizer of each comparative example. The compounding components of each comparative example are shown below.

(Comparative example 1)
Product A Product of Company X Main compounding component: Methoxy ethylene maleic anhydride copolymer salt, carboxymethyl cellulose, light liquid paraffin, white petrolatum (comparative example 2)
Product B Company Y Main compounding ingredients: Methoxy ethylene maleic anhydride copolymer salt, carboxymethyl cellulose, light liquid paraffin, white petrolatum (comparative example 3)
Products C and Z Products Main ingredients: Methoxy ethylene maleic anhydride copolymer salt, carboxymethyl cellulose, light liquid paraffin, white petrolatum

(Examples 12 to 18)
A denture stabilizer was manufactured in the same manner as Example 1, except that each component was blended in the blending amounts shown in Table 2, respectively. In addition, when mix | blending water, after a mixture solidified, water was added during manufacture, and the mixture after addition was knead | mixed by the roller.

(Examples 19 to 39)
A denture stabilizer was manufactured in the same manner as Example 1, except that each component was blended in the blending amounts shown in Table 3, respectively. During the production, a swollen product obtained by swelling carboxymethylcellulose sodium salt (CMC-Na) in glycerin is previously prepared, and the swollen product is added to the solidified mixture after cooling, and the mixture after addition is added to the roller The mixture was kneaded according to
In Examples 24 to 39, the following were used as carboxymethylcellulose sodium salts.
Examples 24 and 25: product name "cellogen F-BSH-12" manufactured by Dai-ichi Kogyo Seiyaku Co., Ltd. Examples 26 and 27: product name "cellogen P-815C" manufactured by Dai-ichi Kogyo Seiyaku Co., Ltd. "Cellogen PM-250L" manufactured by Daiichi Kogyo Seiyaku Co., Ltd. Examples 30 and 31: product name "Cerogen HE1500F" manufactured by Daiichi Kogyo Seiyaku Co., Ltd. Examples 32 and 33: product name "Cerogen F-6HS9" manufactured by Daiichi Kogyo Seiyaku Co., Ltd. Examples 34 to 39: Product name "Cerogen PM-250L" manufactured by Daiichi Kogyo Seiyaku Co., Ltd.

  Each evaluation was performed as follows using each manufactured denturest stabilizer. The details of each evaluation method are as follows.

<Evaluation 1: Evaluation of adhesive strength of denture stabilizer (without water immersion)>
According to the method of measuring the adhesive strength of Japanese Industrial Standard JIS T6525-1: 2013 (adhesive material for denture base stabilization-Part 1: adhesive type denture base stabilization), adhesive strength of adhesive denture (adhesion (adhesion) Force) was measured. In addition, it measured without immersing a sample in water. The measurement conditions are as follows.
Sample holder-flat sample thickness-0.5 mm
Temperature-23 ° C
Measurement environment-in air

<Evaluation 2: Evaluation of adhesive strength of denture stabilizer (with water immersion)>
Adhesive strength of denture stabilizer according to Japanese Industrial Standard JIS T 6525-1: 2013 (Adhesive material for denture base stabilization-Part 1: Adhesive material for adhesive type denture base stabilization, cream type, adhesive strength I and adhesive strength II) The (adhesive force) was measured. The measurement conditions are as follows.
Device-Shimadzu Autograph "AGS-H"
Measurement environment-in air In the above-mentioned JIS standards, it is stated that the adhesive strength of the denture base stabilizing adhesive material must be 5 kPa or more.

<Evaluation 3: Repeated load test>
In order to reproduce the change in tackiness in the mouth in the mouth, adhesion and peeling of each denture stabilizer were repeated in water using the repeated load application device shown in FIG. 1, and the change in load was measured. The details of the measurement conditions are as follows.
Equipment-Immovable Industry "immobile rheometer"
Sample thickness-0.5 mm
Adhesion and peeling speed -20 mm / min Repeat frequency -6 times / min Temperature (water temperature) -23 ° C
Load-9.8 N

The result of having performed the above-mentioned evaluation 1 about Examples 1-11 is shown in FIG.
About the Example 12, 13, the result of performing said evaluation 1 is shown in FIG.
About the product A of Example 12, 14 and a comparative example, the product B, and the product C, the result of having performed said evaluation 1 is shown in FIG.
About the product C of Example 12, 13 and a comparative example, the result of performing said evaluation 3 is shown in FIG.
About the product A of Example 12, 14 and a comparative example, the product B, and the product C, the result of having performed said evaluation 3 is shown in FIG.
About the Example 12, 15-18, the result of having performed said evaluation 3 is shown in FIG.

About Example 19-33, the result of having performed said evaluation 1 is shown in FIG.
About the product A of the comparative example, the product B, and the product C, the result of having performed said evaluation 3 is shown in FIG.
About Examples 19-23, the result of having performed said evaluation 3 is shown in FIG.
The results of the above evaluation 3 are shown in FIG. 11 for Examples 20, 24, 26, 28, 30, and 32.
About the Example 22, 25, 27, 29, 31, 33, the result of performing said evaluation 3 is shown in FIG.
About the Example 34-39, the result of having performed the adhesive strength I of said evaluation 2 is shown in FIG. The result of having performed adhesive strength II of above-mentioned evaluation 2 is shown in FIG.

  As can be understood from the above results, the denture stabilizer of the example can suppress the decrease in the adhesive force even if it is repeatedly subjected to a load by wrinkles and the like, as compared with the denture stabilizer of each product of the comparative example. .

  The denture stabilizer of the present invention is suitably used, for example, in order to stabilize the position of a denture mounted in the oral cavity.

Claims (5)

Denture stabilizer comprising a vegetable oil as a liquid oil containing triglyceride and a bio-based wax (but excluding soy lecithin) . The denture stabilizer of Claim 1 which contains 25 mass% or more of the said vegetable oil as said liquid oil, and contains 10 mass% or more of said biological origin wax . The denture fixer according to claim 1 or 2, wherein the vegetable oil is olive oil or the biological wax is beeswax.   The denture stabilizer of any one of claims 1 to 3, further comprising a carboxymethylcellulose salt. The denture stabilizer according to any one of claims 1 to 4, further comprising at least one of water and a polyhydric alcohol.