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JP6503230B2 - Transmitted light intensity measurement unit - Google Patents
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JP6503230B2 - Transmitted light intensity measurement unit - Google Patents

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JP6503230B2
JP6503230B2 JP2015109678A JP2015109678A JP6503230B2 JP 6503230 B2 JP6503230 B2 JP 6503230B2 JP 2015109678 A JP2015109678 A JP 2015109678A JP 2015109678 A JP2015109678 A JP 2015109678A JP 6503230 B2 JP6503230 B2 JP 6503230B2
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JP2016223878A (en
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佐野 嘉彦
嘉彦 佐野
証英 原田
証英 原田
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Harada Electronics Industry Co Ltd
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Priority to EP16803269.6A priority patent/EP3306305A4/en
Priority to PCT/JP2016/065777 priority patent/WO2016194834A1/en
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    • GPHYSICS
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    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
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    • GPHYSICS
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    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
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    • G01N2201/062LED's
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Description

この発明は、光透過性かつ変形可能な管壁を持つ管路内を流れる流体の濃度をランベルト−ベールの法則に基づいて測定する流体濃度測定装置に用いられ、その管路を横切る透過光の強度を測定する透過光強度測定ユニットに関するものである。   The present invention is used in a fluid concentration measuring apparatus for measuring the concentration of fluid flowing in a conduit having a light transmitting and deformable tube wall based on Lambert-Beer's law, and for transmitting light across the conduit, The present invention relates to a transmitted light intensity measurement unit that measures the intensity.

上述の如き管壁を持つ管路としては、例えば光透過性でかつ変形可能なチューブ壁を持つ樹脂チューブが広く知られ、その樹脂チューブ内を流れる血液等の流体の濃度を測定する従来の流体濃度測定装置としては、例えば特許文献1記載のものが知られており、この流体濃度測定装置は、樹脂チューブの表面上の給光箇所からその樹脂チューブ内に光を供給する光源と、給光箇所に対しその樹脂チューブの直径方向の反対側に位置する受光箇所で給光箇所からその樹脂チューブのチューブ壁内およびその樹脂チューブ内の血液内を通過して来た光を受光してその光の強度を示す信号を出力する受光素子と、を有する透過光測定ユニットを具えている。   As a pipe line having a pipe wall as described above, for example, a resin tube having a light transmitting and deformable tube wall is widely known, and a conventional fluid for measuring the concentration of fluid such as blood flowing in the resin tube As a concentration measuring device, for example, the one described in Patent Document 1 is known, and this fluid concentration measuring device comprises a light source for supplying light from the light supplying spot on the surface of the resin tube into the resin tube, The light from the light-supplying location is received at the light-receiving location located on the opposite side of the resin tube in the diameter direction with respect to the location, and the light passing through the inside of the tube wall of the resin tube and the inside of the resin tube is received And a light receiving element for outputting a signal indicating the intensity of the light.

さらに上記流体濃度測定装置は、給光個所と受光箇所との間の光路距離を複数設定する光路距離設定手段と、それら複数の光路距離のそれぞれにおける受光箇所での光の強度からランベルト−ベールの法則に基づき各光路距離をおいて給光箇所からの光を受光箇所で受光する場合の光の強度と血液の濃度との関係を示す複数の関係式を求め、それら複数の光路距離での関係式に基づいて、受光箇所での光の強度から樹脂チューブ内の血液の濃度を求めて出力する流体濃度出力手段と、を具えている。   Further, the fluid concentration measuring apparatus is provided with optical path distance setting means for setting a plurality of optical path distances between the light supplying portion and the light receiving portion, and the light intensity at the light receiving portion at each of the plurality of optical path distances Based on the law, a plurality of relational expressions indicating the relationship between the light intensity and the blood concentration when light from the light supplying location is received at the light receiving location at each optical path distance are determined, and the relationship at the plurality of optical path distances And a fluid concentration output means for determining and outputting the concentration of blood in the resin tube from the intensity of light at the light receiving portion based on the equation.

国際公開2014−170985号公報International Publication 2014-170985

ところで、上記従来の流体濃度測定装置について研究を進めた結果、本発明者は以下の点を見出した。すなわち、上記従来の流体濃度測定装置では、透過光強度測定ユニットにおける、管路の表面上の給光箇所と光源との間や管路の表面上の受光箇所と受光素子との間で、光が散乱等のために減衰してしまい、光源から樹脂チューブを透過して受光素子に至る光の光量が充分に得られないという不都合があり、測定精度をさらに高めるには透過光強度測定ユニットに改良の余地があることが判明した。   By the way, as a result of advancing research on the above-mentioned conventional fluid concentration measuring device, the inventor found the following points. That is, in the above-mentioned conventional fluid concentration measuring device, light is transmitted between the light supplying location on the surface of the conduit and the light source or between the light receiving location on the surface of the conduit and the light receiving element in the transmitted light intensity measurement unit. Is attenuated due to scattering, etc., and the amount of light from the light source through the resin tube to the light receiving element can not be obtained sufficiently. To further improve the measurement accuracy, the transmitted light intensity measurement unit It turned out that there is room for improvement.

それゆえこの発明は、上述の点に鑑みて、光源から管路を透過して受光素子に至る光の光量を充分に得られるようにすることで従来の透過光強度測定ユニットひいては流体濃度測定装置の課題を有利に解決することを目的とするものである。   Therefore, in view of the above-described point, the present invention is able to obtain a sufficient amount of light from the light source to the light receiving element by transmitting through the pipe line, and thereby the conventional transmitted light intensity measuring unit and thus the fluid concentration measuring device In order to solve the problem of

上記課題を解決するこの発明の透過光強度測定ユニットは、光透過性でかつ変形可能な管壁を持つ管路内を流れる流体の濃度を測定する流体濃度測定装置に用いられるものであって、
前記管路の表面上の給光箇所から前記管路内に光を供給する光源と、
前記給光箇所に対しその管路の直径方向の反対側に位置する受光箇所で、前記給光箇所からその管路の壁内およびその管路内の流体内を通過して来た光を受光してその光の強度を示す信号を出力する受光素子と、
前記光源と前記給光箇所との間の光路および、前記受光素子と前記受光箇所との間の光路上に配置されて前記管壁に当接し、前記管壁の弾性変形により前記管壁に密接する透光部材と、
を具え
前記透光部材は、前記管壁に当接する凸曲面を有する凸レンズであることを特徴とするものである。
A transmitted light intensity measuring unit according to the present invention for solving the above-mentioned problems is used in a fluid concentration measuring apparatus for measuring the concentration of a fluid flowing in a pipe having a light transmitting and deformable pipe wall,
A light source for supplying light into the duct from a light delivery point on the surface of the duct;
At the light receiving point located on the opposite side of the pipe in the diameter direction with respect to the light supplying point, the light from the light supplying point is received the light passing through the fluid in the wall of the pipe and the fluid in the pipe A light receiving element that outputs a signal indicating the intensity of the light;
Optical path on between the sheet light strikes the light source and abutting said tube wall is disposed on the optical path between the light receiving portion and the light receiving element, the pipe wall by the elastic deformation of the tube wall A light transmitting member in close proximity,
The equipped,
The translucent member is characterized in convex der Rukoto having abutting convex surface on the tube wall.

かかるこの発明の透過光強度測定ユニットにあっては、光源と給光箇所との間の光路および、受光素子と受光箇所との間の光路の少なくとも一方に配置された透光部材が管壁に密接するので、それら管壁と透光部材との間に実質的に空気層が介在せず、また、その透光部材の当接部分で管壁の表面の微小な傷や凹凸が潰れて管壁表面が滑らかになる。   In the transmitted light intensity measurement unit according to the present invention, the light transmitting member disposed in at least one of the light path between the light source and the light supplying portion and the light path between the light receiving element and the light receiving portion Because they are in close contact, substantially no air layer intervenes between the tube wall and the light transmitting member, and minute flaws and irregularities on the surface of the tube wall are crushed at the contact portion of the light transmitting member, and the tube is The wall surface becomes smooth.

従って、この発明の透過光強度測定ユニットによれば、管壁と透光部材との間での空気層や管壁表面の凹凸等による光の散乱や吸収がほとんどもしくは全くなくなるので、散乱や吸収による光の減衰を減らすことができ、光源から管路を透過して受光素子に至る光の光量を充分に得ることができる。   Therefore, according to the transmitted light intensity measurement unit of the present invention, scattering or absorption of light due to the unevenness of the air layer or the surface of the tube wall between the tube wall and the light transmitting member is almost or completely eliminated. Attenuation of light due to the light source can be reduced, and a sufficient amount of light can be obtained from the light source through the conduit to the light receiving element.

しかも、この発明の透過光強度測定ユニットによれば、前記透光部材は、前記管壁に当接する凸曲面を有する凸レンズであるので、透光部材で光を集束させて透光部材と管壁との間で光を効率的に通過させることができる。 Moreover, according to the transmitted light intensity measurement unit of the present invention, the translucent member, because it is a convex lens having a contact with the convex surface on the tube wall, and a translucent member focuses the light in the light transmitting member wall Light can be efficiently transmitted between them.

なお、この発明の透過光強度測定ユニットにおいては、前記凸レンズは、ボールレンズであると、透光部材の、特に管壁に当接する部分に光を集束させて透光部材と管壁との間で光をより効率的に通過させることができるので、好ましい。
In the transmitted light intensity measurement unit according to the present invention, if the convex lens is a ball lens, light is focused on a portion of the light transmitting member, in particular, a portion of the light transmitting member that contacts the tube wall. It is preferable because the light can be transmitted more efficiently.

(a),(b)は、この発明の透過光強度測定ユニットの一実施形態を示す正面図および(a)のA−A線に沿う断面図である。(A), (b) is the front view which shows one Embodiment of the transmitted light intensity measurement unit of this invention, and sectional drawing in alignment with the AA of (a). (a)は、上記実施形態の透過光強度測定ユニットにおけるボールレンズの集光状態を示す説明図、(b)は、この発明の透過光強度測定ユニットの他の一実施形態における半球レンズの集光状態を示す説明図である。(A) is explanatory drawing which shows the condensing state of the ball lens in the transmitted light intensity measurement unit of the said embodiment, (b) is a collection of the hemispherical lens in other one Embodiment of the transmitted light intensity measurement unit of this invention It is an explanatory view showing a light state.

以下、本発明の実施の形態を図面に基づき詳細に説明する。ここに、図1(a)は、この発明の透過光強度測定ユニットの一実施形態を示す正面図、図1(b)は、図1(a)のA−A線に沿う断面図である。   Hereinafter, embodiments of the present invention will be described in detail based on the drawings. Here, FIG. 1 (a) is a front view showing an embodiment of the transmitted light intensity measurement unit according to the present invention, and FIG. 1 (b) is a cross-sectional view taken along the line A-A of FIG. 1 (a). .

この実施形態の透過光強度測定ユニットは、光透過性かつ変形可能な管壁としてのチューブ壁を持つ管路としての樹脂チューブ内を流れる流体の濃度をランベルト−ベールの法則に基づいて測定する流体濃度測定装置に用いられ、その管路を横切る透過光の強度を測定するもので、上述の如き管路としては例えば、光透過性かつ変形可能なチューブ壁を持つ樹脂チューブが周知であり、また、その様な管路内を流れる流体の濃度をランベルト−ベールの法則に基づいて測定する流体濃度測定装置としては、例えば本願出願人が先に特許文献1で開示した、樹脂チューブ内を流れる血液の濃度をランベルト−ベールの法則に基づいて測定する流体濃度測定装置が知られている。   The transmitted light intensity measurement unit of this embodiment is a fluid that measures the concentration of fluid flowing in a resin tube as a conduit having a tube wall as a light transmitting and deformable tube wall based on Lambert-Beer's law. It is used in a concentration measuring device to measure the intensity of transmitted light across the conduit, and as the conduit as described above, for example, a resin tube having a light transmitting and deformable tube wall is known, and As a fluid concentration measuring device for measuring the concentration of fluid flowing in such a conduit based on Lambert-Beer's law, for example, blood flowing in a resin tube disclosed by the present applicant in Patent Document 1 earlier A fluid concentration measuring device is known which measures the concentration of H.sub.2 based on Lambert-Veil's law.

上記流体濃度測定装置に用いられるこの実施形態の透過光強度測定ユニットは、長手方向中央部に上向きに開口したU字状の切欠き部1aを有するチューブホルダー1と、そのチューブホルダー1に切欠き部1aを挟んで互いに対向するように設けられた発光ユニット2および受光ユニット3と、を具えており、チューブホルダー1は、切欠き部1a内に樹脂チューブ4を、チューブホルダー1を横切る向きで保持することができる。   The transmitted light intensity measurement unit of this embodiment used in the fluid concentration measurement apparatus comprises a tube holder 1 having a U-shaped notch 1a opened upward at the center in the longitudinal direction, and a notch in the tube holder 1 The light emitting unit 2 and the light receiving unit 3 provided so as to face each other across the portion 1a, and the tube holder 1 extends the resin tube 4 in the notch 1a in a direction crossing the tube holder 1 Can be held.

発光ユニット2は、チューブホルダー1の切欠き部1a内に保持された樹脂チューブ4の表面上の給光箇所Sから樹脂チューブ4内に光を供給する光源として、電気を供給されて発光する例えば発光ダイオード(LED)あるいはレーザーダイオード等の発光素子5を有し、また受光ユニット3は、給光箇所Sに対し樹脂チューブ4の直径方向の反対側に位置する受光箇所Rで、給光箇所Sからその樹脂チューブ4の管壁としてのチューブ壁4a内およびその樹脂チューブ4内を流れる血液内を横切って通過して来た光を受光してその光の強度を示す電気信号を出力する例えばフォトダイオードやフォトトランジスタ等の受光素子6を有している。   The light emitting unit 2 is supplied with electricity and emits light as a light source for supplying light into the resin tube 4 from the light supplying spot S on the surface of the resin tube 4 held in the notch portion 1 a of the tube holder 1, for example The light receiving portion 3 has a light emitting element 5 such as a light emitting diode (LED) or a laser diode, and the light receiving unit 3 is a light receiving portion S at a light receiving portion R located on the opposite side of the resin tube 4 in the diameter direction. For example, it receives light passing from inside the tube wall 4a as the tube wall of the resin tube 4 and across blood in the resin tube 4 and outputs an electrical signal indicating the intensity of the light, for example, A light receiving element 6 such as a diode or a phototransistor is provided.

発光ユニット2はさらに、発光素子5と給光箇所Sとの間の光路上に配置されて樹脂チューブ4のチューブ壁4aの給光箇所Sに当接し、その給光箇所Sでチューブ壁4aを弾性的に凹ませてチューブ壁4aに密接する、透光部材としてのボールレンズ7を具え、受光ユニット3も同様に、受光素子6と受光箇所Rとの間の光路上に配置されて樹脂チューブ4のチューブ壁4aの受光箇所Rに当接し、その受光箇所Rでチューブ壁4aを弾性的に凹ませてチューブ壁4aに密接する、透光部材としてのボールレンズ7を具えている。   The light emitting unit 2 is further disposed on the optical path between the light emitting element 5 and the light supplying spot S, and abuts the light supplying spot S of the tube wall 4a of the resin tube 4 and the tube wall 4a at the light supplying spot S The light receiving unit 3 is similarly disposed on the light path between the light receiving element 6 and the light receiving portion R and is a resin tube. The ball lens 7 as a light transmitting member is elastically recessed to be in close contact with the tube wall 4a. A ball lens 7 as a light transmitting member is in contact with the light receiving portion R of the tube wall 4a of 4 and elastically indents the tube wall 4a at the light receiving portion R to be in close contact with the tube wall 4a.

図2(a)は、上記実施形態の透過光強度測定ユニットにおける発光ユニット2側のボールレンズ7の集光状態を代表として示す説明図であり、ここでは図示しない発光素子5から出た概略平行光線の光Lは、ボールレンズ7内に入ってある程度集光されて細くなった状態で給光箇所Sを通り、樹脂チューブ4のチューブ壁4a内に供給されてさらに集光される。そして受光ユニット3側でも、樹脂チューブ4のチューブ壁4a内から受光箇所Rを通ってボールレンズ7に入った光が、ボールレンズ7内である程度集光され、概略平行光線となってボールレンズ7を出て受光素子6に入る。   FIG. 2A is an explanatory view showing a state of light collection of the ball lens 7 on the side of the light emitting unit 2 in the transmitted light intensity measurement unit of the above embodiment as a representative, and here approximately parallel from the light emitting element 5 not shown. The light beam L enters the inside of the ball lens 7 and is condensed to a certain extent and passes through the light supplying portion S in a narrowed state, and is supplied into the tube wall 4a of the resin tube 4 and further condensed. Then, even on the light receiving unit 3 side, the light entering the ball lens 7 from the inside of the tube wall 4 a of the resin tube 4 through the light receiving portion R is condensed to some extent within the ball lens 7 and becomes approximately parallel light To the light receiving element 6.

そしてこの実施形態の透過光強度測定ユニットにあっては、発光素子5と給光箇所Sとの間の光路および、受光素子6と受光箇所Rとの間の光路の両方の光路上に配置されたボールレンズ7がチューブ壁4aに密接するので、それらチューブ壁4aとボールレンズ7との間に実質的に空気層が介在せず、また、そのボールレンズ7の当接部分でチューブ壁4aの表面の微小な傷や凹凸が潰れてチューブ壁表面が滑らかになる。   And, in the transmitted light intensity measurement unit of this embodiment, it is disposed on the optical path of both the optical path between the light emitting element 5 and the light supplying point S and the optical path between the light receiving element 6 and the light receiving point R. Because the ball lens 7 is in close contact with the tube wall 4a, substantially no air layer is interposed between the tube wall 4a and the ball lens 7, and the contact portion of the ball lens 7 The minute flaws and irregularities on the surface are crushed and the tube wall surface becomes smooth.

従って、この実施形態の透過光強度測定ユニットによれば、チューブ壁4aとボールレンズ7との間での空気層やチューブ壁表面の凹凸等による光の散乱や吸収がほとんどもしくは全くなくなるので、散乱や吸収による光の減衰を減らすことができ、発光素子5から樹脂チューブ4を透過して受光素子6に至る光の光量を充分に得ることができる。   Therefore, according to the transmitted light intensity measurement unit of this embodiment, scattering or absorption of light due to the air layer between the tube wall 4a and the ball lens 7 or unevenness of the tube wall surface is hardly or completely eliminated. Attenuation of light due to absorption or absorption can be reduced, and the amount of light from the light emitting element 5 through the resin tube 4 to the light receiving element 6 can be sufficiently obtained.

しかも、この実施形態の透過光強度測定ユニットによれば、透光部材は、チューブ壁4aに当接する凸曲面を有する凸レンズの一種のボールレンズ7であるので、透光部材の、特にチューブ壁4aの給光箇所Sおよび受光箇所Rに当接する部分に光を集束させて、光をより効率的に管壁に通すことができる。   Moreover, according to the transmitted light intensity measurement unit of this embodiment, since the light transmitting member is a kind of ball lens 7 of a convex lens having a convex curved surface contacting the tube wall 4a, the light transmitting member, in particular, the tube wall 4a. The light can be focused on a portion of the light source S and the light receiving portion R, and the light can be more efficiently passed through the tube wall.

かかる実施形態の透過光強度測定ユニットで、発光ユニット2側のボールレンズ7と受光ユニット3側のボールレンズ7との間隔を異ならせたものを2つ、例えば特許文献1の図1(a)記載の流体濃度測定装置に用いれば、特許文献1の明細書に記載されているように、発光素子ドライバーによりそれぞれ駆動された二つの発光ユニット2内の発光素子5から発光された光は、二つの透過光強度測定ユニットの発光ユニット2と受光ユニット3との間に挟まれて直径方向に圧縮変形された一本の樹脂チューブ4の、発光ユニット2に近い側のチューブ壁4aと、その樹脂チューブ4の内部を流れる血液と、発光ユニット2から遠い側(反対側)すなわち受光ユニット3に近い側のチューブ壁4aと、を透過し、互いに異なる距離の光路を経て、二つの受光ユニット3内の受光素子6にそれぞれ受光され、二つの受光ユニット3内の受光素子6が、受光した光の強度に応じたレベルの電気信号をそれぞれ出力する。   In the transmitted light intensity measurement unit according to this embodiment, two ones having different distances between the ball lens 7 on the light emitting unit 2 side and the ball lens 7 on the light receiving unit 3 side, for example, FIG. As described in the specification of Patent Document 1, when used in the fluid concentration measuring device described above, the light emitted from the light emitting elements 5 in the two light emitting units 2 respectively driven by the light emitting element driver is Tube wall 4a of the one resin tube 4 compressed and deformed in the diameter direction between the light emitting unit 2 and the light receiving unit 3 of two transmitted light intensity measuring units, and the tube wall 4a near the light emitting unit 2, and the resin The blood flows through the inside of the tube 4 and the tube wall 4a on the side (opposite side) from the light emitting unit 2 (the opposite side), that is, the side closer to the light receiving unit 3 and passes through optical paths of different distances. , Respectively received by the light receiving element 6 of the two light receiving unit 3, the light receiving element 6 of the two light receiving unit 3 outputs the electrical signal of a level corresponding to the intensity of the received light, respectively.

そして二つの受光ユニット3内の受光素子6の出力信号はそれぞれ、例えばアンプで増幅され、ローパスフィルタで高周波のノイズ成分を除去され、アナログ−デジタルコンバータ(A/D)でアナログ信号からデジタル信号に変換されて、中央処理ユニット(CPU)に入力される。CPUは、発光素子ドライバーの作動を制御して、好ましくは二つの透過光強度測定ユニットの発光ユニット2を選択的に発光させて相互の干渉を回避するとともに、それぞれの光路距離での受光素子6の出力信号から既知のように、ランベルト−ベールの法則に基づき各光路距離をおいて給光箇所Sからの光を受光箇所Rで受光する場合の光の強度と血液の濃度との関係を示す複数の関係式を求め、それら複数の光路距離での関係式に基づいて、何れかの受光素子6の出力信号から樹脂チューブ4内の血液の濃度を求め、その濃度データを示す信号を出力する。   The output signals of the light receiving elements 6 in the two light receiving units 3 are respectively amplified by, for example, an amplifier, high frequency noise components are removed by a low pass filter, and analog signals are converted to digital signals by an analog-digital converter (A / D). It is converted and input to a central processing unit (CPU). The CPU controls the operation of the light emitting element driver to selectively cause the light emitting units 2 of the two transmitted light intensity measurement units to emit light selectively to avoid mutual interference, and the light receiving elements 6 at respective optical path distances Shows the relationship between the light intensity and the blood concentration when light from the light supplying spot S is received by the light receiving spot R at each optical path distance based on Lambert-Beer's law as known from the output signal of A plurality of relational expressions are obtained, and the concentration of blood in the resin tube 4 is obtained from the output signal of any of the light receiving elements 6 based on the relational expressions at the plurality of optical path distances, and a signal indicating the concentration data is output .

従って、上述した実施形態の透過光強度測定ユニットを用いた流体濃度測定装置によれば、発光素子5から樹脂チューブ4を透過して受光素子6に至る光の光量を充分に得ることができるので、血液濃度の測定精度を従来よりもさらに高めることができる。   Therefore, according to the fluid concentration measuring apparatus using the transmitted light intensity measuring unit of the embodiment described above, the light quantity of light passing from the light emitting element 5 through the resin tube 4 to the light receiving element 6 can be sufficiently obtained. The measurement accuracy of the blood concentration can be further enhanced than before.

図2(b)は、この発明の透過光強度測定ユニットの他の一実施形態における半球レンズの集光状態を示す説明図であり、この実施形態の透過光強度測定ユニットでは、発光ユニット2および受光ユニット3の透光部材として、先の実施形態におけるボールレンズ7に代えて半球レンズ8が用いられ、それらの半球レンズ8の球面側が給光箇所Sおよび受光箇所Rに当接し、それら給光箇所Sおよび受光箇所Rでチューブ壁4aを弾性的に凹ませてチューブ壁4aに密接する。   FIG. 2 (b) is an explanatory view showing a condensed state of a hemispherical lens in another embodiment of the transmitted light intensity measurement unit of the present invention, and in the transmitted light intensity measurement unit of this embodiment, the light emitting unit 2 and As the light transmitting member of the light receiving unit 3, the hemispherical lens 8 is used instead of the ball lens 7 in the previous embodiment, and the spherical side of the hemispherical lens 8 abuts on the light supplying spot S and the light receiving spot R The tube wall 4a is elastically recessed at the point S and the light receiving point R to be in close contact with the tube wall 4a.

この実施形態の透過光強度測定ユニットによっても、先の実施形態ほどではないが、発光素子5から樹脂チューブ4を透過して受光素子6に至る光の光量を充分に得ることができる。   Even with the transmitted light intensity measurement unit of this embodiment, although not as large as the previous embodiment, it is possible to sufficiently obtain the light quantity of the light from the light emitting element 5 to the resin tube 4 to reach the light receiving element 6.

以上、図示例に基づき説明したが、この発明は上述の例に限定されるものでなく特許請求の範囲の記載範囲内で適宜変更し得るものであり、例えば上記実施形態では透光部材としてのボールレンズ7や半球レンズ8を発光ユニット2および受光ユニット3の両方に設けているが、何れか一方、特に発光ユニット2側のみに設けるようにしても良い。そしてその場合に受光ユニット3側の透光部材は、平坦な面で樹脂チューブ4のチューブ壁4aに当接するものでも良い。   As mentioned above, although demonstrated based on the example of illustration, this invention is not limited to the above-mentioned example, It can change suitably within the statement range of a claim, for example, it is as a translucent member in the above-mentioned embodiment. Although the ball lens 7 and the hemispherical lens 8 are provided in both the light emitting unit 2 and the light receiving unit 3, they may be provided only on one side, in particular, only on the light emitting unit 2 side. In that case, the light transmitting member on the light receiving unit 3 side may be in contact with the tube wall 4 a of the resin tube 4 with a flat surface.

また、上記実施形態の透過光強度測定ユニットを用いた上記例の流体濃度測定装置では、液体としての血液の濃度を測定したが、これに代えて、他の液体の濃度測定に用いることもでき、その場合には光源から供給する光として、その液体による吸収率が高い波長の光を選択すると、管壁の厚さ等に応じて受光箇所での光の強度に差異が出易いので好ましい。   Further, in the fluid concentration measuring apparatus of the above example using the transmitted light intensity measuring unit of the above embodiment, the concentration of blood as a liquid is measured, but instead it may be used for measuring the concentration of other liquids. In that case, it is preferable to select light of a wavelength having a high absorptivity by the liquid as the light supplied from the light source, because the light intensity at the light receiving portion tends to differ depending on the thickness of the tube wall and the like.

そして、上記例の流体濃度測定装置では、二種類の光路距離において光供給箇所で光を供給し、その光を受光箇所で受光して光の強度を求めているが、これに代えて、三種類以上の光路距離を設定してそれぞれ受光箇所で光の強度を求めてもよく、このようにすれば、得られた結果を平均化する等により測定精度をより高めることができる。   Then, in the fluid concentration measuring device of the above example, light is supplied at the light supply location at two types of optical path distances, and the light is received at the light reception location to obtain the light intensity. The light path distance may be set more than the kind, and the light intensity may be determined at each light receiving location. In this way, it is possible to further improve the measurement accuracy by averaging the obtained results.

かくしてこの発明の透過光強度測定ユニットによれば、管壁と透光部材との間での空気層や管壁表面の凹凸等による光の散乱や吸収がほとんどもしくは全くなくなるので、散乱や吸収による光の減衰を減らすことができ、光源から管路を透過して受光素子に至る光の光量を充分に得ることができる。   Thus, according to the transmitted light intensity measurement unit of the present invention, scattering or absorption of light due to the unevenness of the air layer or the surface of the tube wall between the tube wall and the light transmitting member is almost or completely eliminated. Attenuation of light can be reduced, and a sufficient amount of light can be obtained from the light source through the conduit to the light receiving element.

1 チューブホルダー
1a 切欠き部
2 発光ユニット
3 受光ユニット
4 樹脂チューブ
4a チューブ壁
5 発光素子
6 受光素子
7 ボールレンズ
8 半球レンズ
L 光
1 tube holder 1a notch 2 light emitting unit 3 light receiving unit 4 resin tube 4 a tube wall 5 light emitting element 6 light receiving element 7 ball lens 8 hemispherical lens L light

Claims (3)

光透過性でかつ変形可能な管壁を持つ管路内を流れる流体の濃度を測定する流体濃度測定装置に用いられる透過光強度測定ユニットにおいて、
前記管路の表面上の給光箇所から前記管路内に光を供給する光源と、
前記給光箇所に対しその管路の直径方向の反対側に位置する受光箇所で、前記給光箇所からその管路の壁内およびその管路内の流体内を通過して来た光を受光してその光の強度を示す信号を出力する受光素子と、
前記光源と前記給光箇所との間の光路および、前記受光素子と前記受光箇所との間の光路上に配置されて前記管壁に当接し、前記管壁の弾性変形により前記管壁に分離可能に密接する透光部材と、
を具え
前記透光部材は、前記管壁に当接する凸曲面を有する凸レンズであることを特徴とする透過光強度測定ユニット。
In a transmitted light intensity measuring unit used in a fluid concentration measuring device for measuring the concentration of a fluid flowing in a conduit having a light transmitting and deformable tube wall,
A light source for supplying light into the duct from a light delivery point on the surface of the duct;
At the light receiving point located on the opposite side of the pipe in the diameter direction with respect to the light supplying point, the light from the light supplying point is received the light passing through the fluid in the wall of the pipe and the fluid in the pipe A light receiving element that outputs a signal indicating the intensity of the light;
Optical path on between the sheet light strikes the light source and abutting said tube wall is disposed on the optical path between the light receiving portion and the light receiving element, the pipe wall by the elastic deformation of the tube wall A translucent member that is in close contact with each other in a separable manner ;
The equipped,
The translucent member, the transmitted light intensity measurement unit, wherein the convex lens der Rukoto having abutting convex surface on the tube wall.
前記凸レンズは、ボールレンズであることを特徴とする、請求項記載の透過光強度測定ユニット。 The convex lens is characterized in that a ball lens, transmitted light intensity measurement unit according to claim 1, wherein. 前記光透過性でかつ変形可能な管壁を持つ管路は、樹脂チューブであることを特徴とする、請求項1または2記載の透過光強度測定ユニット。 The transmission light intensity measuring unit according to claim 1 or 2 , wherein the conduit having the light transmitting and deformable tube wall is a resin tube.
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US12613182B2 (en) 2021-06-29 2026-04-28 Sony Group Corporation Concentration measurement device
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CN101430275B (en) * 2008-12-04 2010-09-29 清华大学深圳研究生院 Device and method for non-contact measurement of solution concentration
US9695795B2 (en) * 2012-04-19 2017-07-04 Energy Recovery, Inc. Pressure exchange noise reduction
JP6264741B2 (en) 2013-04-16 2018-01-24 横河電機株式会社 Spectroscopic analyzer
EP2988113B1 (en) 2013-04-18 2024-09-18 Nipro Corporation Fluid concentration measuring device
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