JP6608620B2 - Topical skin preparation - Google Patents

Description

  The present invention relates to an external preparation for skin.

  Vaseline is widely used as a base for external preparations for skin because it is excellent in safety and moisture retention. Among the products currently on the market, the effectiveness of 100% petrolatum is recognized. However, in order to increase the moisturizing property of the external preparation for skin, when it is formulated with petrolatum at a high concentration such as 100% petrolatum, petrolatum itself has a sticky property, so the feeling of use is remarkably inferior. There is.

  Patent Document 1 describes a composition in which a specific copolymer is blended with 50% to 99.95% by mass of petroleum jelly in order to reduce stickiness due to petroleum jelly. However, since this composition is diluted when used as a cosmetic composition, the final petrolatum content is 30% by mass or less, and a preparation containing a high concentration of petrolatum such as 50% by mass or more. However, it cannot solve problems such as stickiness. Patent Document 2 discloses a technique for eliminating a sticky feeling by removing a polar substance contained in petrolatum using a column chromatography method. However, in this technique, petrolatum is dissolved in a nonpolar solvent, passed through a column filled with a filler to retain the polar substance contained in petrolatum, and then the nonpolar solvent is passed through the column. Therefore, the process of obtaining only the nonpolar solvent fraction is essential, and there is a disadvantage that the manufacturing process becomes complicated.

  On the other hand, Patent Document 3 describes that stickiness due to panthenols can be suppressed by adding hyaluronic acid to a skin external preparation containing a high concentration of panthenols. However, there is no description about using hyaluronic acid for reducing stickiness in a topical skin preparation containing petrolatum at a high concentration.

Special table 2013-538835 gazette JP 2004-345999 A JP 2014-162756 A

  In view of the problems associated with such conventional techniques, an object of the present invention is to provide an external preparation for skin that has a high concentration of petrolatum and is non-sticky and has excellent usability.

  As a result of intensive studies to solve the above-mentioned problems, the inventors of the present invention obtain a skin external preparation excellent in usability by containing hyaluronic acid in petrolatum and containing petrolatum in a high concentration without being sticky. As a result, the present invention has been completed.

That is, the gist of the present invention is as follows.
[1] From [A] 50.0 wt% to 99.9 wt% petrolatum (hereinafter also referred to as “[A] petrolatum”), [B] glucosaminoglycan and salts thereof, and derivatives thereof A skin external preparation containing at least one component (hereinafter also referred to as [B] component) selected from the group consisting of:
[2] The external skin preparation according to [1], wherein the [B] component is at least one component selected from the group consisting of hyaluronic acid and salts thereof, and derivatives thereof.
[3] The external skin preparation according to [2], wherein the [B] component is at least one component selected from the group consisting of sodium hyaluronate, a hyaluronic acid hydrolyzate, and acetylated hyaluronic acid.
[4] The external preparation for skin according to any one of [1] to [3], which is an ointment, an emulsifier, or a gel.

  ADVANTAGE OF THE INVENTION According to this invention, although it contains petrolatum in high concentration, it is non-sticky and can provide the skin external preparation excellent in the usability | use_condition. The external preparation for skin of the present invention has good spreading on the skin and good skin familiarity, and also does not easily cause shine, making the skin after application fresh and moist.

It is a figure which shows the result of having evaluated "Nobi" about the skin external preparation of the Example of this invention, and a comparative example. It is a figure which shows the result of having evaluated "skin familiarity" about the skin external preparation of the Example of this invention, and a comparative example. It is a figure which shows the result of having evaluated "freshness" about the skin external preparation of the Example of this invention, and a comparative example. It is a figure which shows the result of having evaluated "stickiness" about the skin external preparation of the Example and comparative example of this invention. It is a figure which shows the result of having evaluated "tekari" about the skin external preparation of the Example and comparative example of this invention. It is a figure which shows the result of having evaluated "moist feeling" about the skin external preparation of the Example of this invention, and a comparative example.

  Hereinafter, the skin external preparation of the present invention will be described in detail.

[Skin external preparation]
The skin external preparation of the present invention comprises [A] petrolatum ([A] petrolatum) of 50.0 wt% or more and 99.9 wt% or less, [B] glucosaminoglycan and a salt thereof, and derivatives thereof. And at least one component selected from the group (component [B]). In topical skin preparations containing 50.0% by weight or more of petrolatum, by adding glucosaminoglycan, stickiness, which is one of the challenges of petrolatum preparations, can be significantly reduced, improving the feeling of use. Can be made. The external preparation for skin of the present invention has good spreading on the skin and good skin familiarity, and also does not easily cause shine, making the skin after application fresh and moist. In particular, since it spreads well, it can be easily applied to a wide area such as the back of the hand, face, back, abdomen, arms and legs. The external preparation for skin of the present invention may contain other optional components in addition to the essential components [A] Vaseline and [B] as long as the effects of the present invention are not impaired. Hereinafter, these essential components and optional components will be described.

<[A] Petrolatum>
Vaseline contained in the external preparation for skin of the present invention is semi-solid obtained by purifying a mixture of hydrocarbons, and is not particularly limited as long as it is usually used in pharmaceuticals, quasi drugs, and cosmetics. .

  In the external preparation for skin of the present invention, either yellow petrolatum or white petrolatum may be used. If it has sufficient safety and moisture retention when used as an external preparation for skin, the degree of purification is not particularly limited, but from the viewpoint of hypoallergenicity, petrolatum with a low impurity content is preferable, White petrolatum is more preferred.

  In the skin external preparation of the present invention, Sun White P-150, Sun White S-200 (manufactured by Nikko Rica Co., Ltd.), Ultima White, Snow White V, Peren Snow, Yellow Petrolatum (manufactured by Penreco), CROLATUM V It is also possible to use commercially available petrolatum such as (made by Croda Japan).

  In the skin external preparation of this invention, the said petrolatum may be used individually by 1 type, and may be used in combination of 2 or more types arbitrarily.

  The blending amount of petrolatum is 50.0 wt% or more and 99.9 wt% or less with respect to 100 wt% of the external preparation for skin. In order to improve the moisture retention of the external preparation for skin of the present invention, the higher the petrolatum content, the better. However, from the viewpoint of reducing stickiness and improving the feeling of use, it is preferable that the petrolatum content is low. In the external preparation for skin of the present invention, by adding the glucosaminoglycan described later, its stickiness can be reduced, so it can contain petrolatum at a high concentration without impairing the feeling of use. Considering the balance, the blending amount of petrolatum is preferably 60.0% by weight or more and 96.0% by weight or less, and 65.0% by weight or more and 93.0% by weight with respect to 100% by weight of the external preparation for skin. More preferably, it is 70.0 weight% or more and 90.0 weight% or less. In addition, when the blending amount of petrolatum in the external preparation for skin of the present invention is less than 50.0% by weight, the moisture retention becomes insufficient, and when it exceeds 99.9% by weight, sufficient stickiness is obtained even if glucosaminoglycan is blended. It cannot be reduced.

<[B] component>
The external preparation for skin of the present invention contains at least one component selected from the group consisting of [B] glucosaminoglycan and salts thereof, and derivatives thereof, in addition to [A] petrolatum.

  The glucosaminoglycan (Glycosaminoglycan) is a linear polysaccharide composed of disaccharides composed of glucosamine or galactosamine and glucuronic acid, iduronic acid or galactose. Examples of glucosaminoglycans include hyaluronic acid, chondroitin, chondroitin sulfate, jalluronic acid, heparan, keratan and the like. The salt of glucosaminoglycan is not particularly limited as long as it is pharmaceutically, pharmacologically or physiologically acceptable. Furthermore, as derivatives of glucosaminoglycan and its salts, derivatives and various enzymes obtained by etherification, esterification, amidation, acetylation, acetalization, etc. of hydroxyl group, carboxyl group, etc. of glucosaminoglycan, etc. The hydrolyzate partially decomposed by the above, the hydrolyzate partially decomposed by acid hydrolysis, and the bonded product cross-linked by the cross-linking agent.

  These glucosaminoglycans and salts thereof and derivatives thereof may be used alone or in any combination of two or more.

  Among the glucosaminoglycans and the like, hyaluronic acid, its salt, and derivatives thereof are particularly preferable from the viewpoint of the stickiness reducing effect in the external preparation for skin of the present invention. Hyaluronic acid is a polymer composed of the basic structure (repeating unit) of GlcUA-GlcNAc in which glucuronic acid (GlcUA) and N-acetylglucosamine (GlcNAc) are combined, and is a known polymer compound that exhibits a moisturizing action. is there.

  The hyaluronic acid salt is not particularly limited as long as it is pharmaceutically, pharmacologically or physiologically acceptable. Examples of the salt of hyaluronic acid include a salt with an organic base and a salt with an inorganic base.

  Examples of the salt with the organic base include salts with organic amines such as methylamine, triethylamine, triethanolamine, morpholine, piperazine, pyrrolidine, tripyridine, and picoline. Examples of the salt with the inorganic base include ammonium salts; alkali metal salts such as sodium and potassium; alkaline earth metal salts such as calcium and magnesium; salts with metals such as aluminum and the like.

  Among these salts, from the viewpoint of excellent effect of reducing the stickiness of petrolatum in the external preparation for skin of the present invention, salts with inorganic bases are preferred, alkali metal salts are more preferred, sodium salts and potassium salts are more preferred, Sodium salt is particularly preferred. These hyaluronic acid salts may be used alone or in any combination of two or more.

The origin of the hyaluronic acid and its salt is not particularly limited. For example, the hyaluronic acid and its salt may be obtained from chicken crowns, may be derived from microorganisms, or may be synthetic products. Good. The viscosity average molecular weight of hyaluronic acid and salts thereof used in the external preparation for skin of the present invention is not particularly limited, but is, for example, 10 million to 5 million, preferably 10 thousand to 4 million, more preferably 1 Examples include those within the range of 10,000 to 3,000,000, more preferably 100,000 to 2,500,000, particularly preferably 500,000 to 2,000,000. Here, the viscosity average molecular weight can be determined by a known measuring method. Specifically, hyaluronic acid or a salt thereof (dried product) is dissolved in a 0.2 M sodium chloride solution, and the intrinsic viscosity (η) at 30 ± 0 ° C. is obtained with an Ubbelohde viscometer, and the Laurent equation (η (intrinsic viscosity) is obtained. ) = 3.6 × 10 ⁻⁴ · M ^0.78 : where M is the viscosity average molecular weight), the viscosity average molecular weight is calculated. The intrinsic viscosity (η) is measured according to the 16th revised Japanese Pharmacopoeia General Test Method Viscosity Measurement Method Method 1: Capillary Viscometer Method.

  Derivatives of the above-mentioned hyaluronic acid and its salts include derivatives obtained by etherification, esterification, amidation, acetylation, acetalization, etc. of hydroxyl groups and carboxyl groups such as hyaluronic acid, and partial degradation by enzymes such as hyaluronidase The hydrolyzed product of hyaluronic acid, partially hydrolyzed hyaluronic acid hydrolyzed by acid hydrolysis, and crosslinked hyaluronic acid crosslinked by a crosslinking agent. Among these derivatives, acetylated hyaluronic acid and hyaluronic acid hydrolyzate are preferable from the viewpoint of being excellent in the effect of reducing stickiness due to petrolatum in an external preparation for skin.

  The derivative of the above hyaluronic acid and its salt can be produced by a conventionally known method. There are various types of hyaluronic acid and its salts, and derivatives of hyaluronic acid and its salts, and these commercially available products can also be used in the present invention. These commercially available products include, for example, hyaluronic acid HA-LQ-RS, hyaluronic acid HA-LQ60, sodium hyaluronate HA-QA, hyaluro-oligo, hyarober, hyarozin (manufactured by Kewpie), sodium hyaluronate HA12 NB, bio Sodium hyaluronate HA20N, acetylated sodium hyaluronate (manufactured by Shiseido), hyaluronic acid FCH-120, hyaluronic acid FCH-121C (manufactured by Kikkoman Biochemifa), hyaluronic acid FCH-SU (manufactured by Kibun Food Chemifa) ), HYALU-CAGE SYSTEM (manufactured by IRA srl), and the like.

  The blending amount of the component [B] in the external preparation for skin of the present invention is not particularly limited as long as it has an effect of sufficiently reducing stickiness, but is 0.000001% by weight or more from the viewpoint of a balance between moisturizing property and feeling of use. % By weight or less, preferably 0.00001% by weight or more and 5.0% by weight or less, more preferably 0.0001% by weight or more and 3.0% by weight or less, and more preferably 0.001% by weight or more and 1.0% by weight or less. Is particularly preferred. In addition, in this invention, [B] component may be used individually by 1 type, or may be used in combination of 2 or more type.

  About the compounding ratio of [A] petroleum jelly and [B] ingredient in skin external preparation of the present invention, [B] ingredient may be 0.000001 weight part-20 weight part to 100 weight part of [A] petroleum jelly. Preferably, it is 0.00001 parts by weight to 10 parts by weight, more preferably 0.0001 parts by weight to 5.0 parts by weight, and 0.001 parts by weight to 1.5 parts by weight. Is particularly preferred.

<Optional component>
The external preparation for skin of the present invention can contain optional components other than the essential components for the purpose of enhancing or reinforcing the effects of the present invention and imparting other effects. Such optional ingredients include polyhydric alcohols and / or glycol ethers, surfactants, liquid oils, cell activation ingredients, antibacterial ingredients, anti-inflammatory ingredients, anti-inflammatory analgesic ingredients, antipruritic ingredients, vitamins, local anesthetic ingredients , Moisturizing component, whitening component, antioxidant component, anti-aging component, keratin softening component, blood circulation promoting component, component having action to prevent and / or repair DNA damage, UV absorbing component, UV scattering component, astringent component, hair growth component , Antihistamine components, antiseptic components, other additives, and the like.

  In addition, these arbitrary components may be used individually by 1 type, or may be used in combination of 2 or more type. Moreover, the compounding quantity can be suitably selected from the range well-known to those skilled in the art. Moreover, what corresponds to the following several components, and the thing applicable also to the base and support | carrier mentioned later show an effect | action as the various various components in this invention.

As the polyhydric alcohol, for example, a polyhydric alcohol having 2 to 6 carbon atoms and 2 to 4 hydroxyl groups can be used. Specifically, for example, ethylene glycol, propylene glycol, 1,3-propanediol (trimethylene glycol), 1,2-butylene glycol, 1,3-butylene glycol, 2,3-butylene glycol, 1,4- Butanediol (tetramethylene glycol), 2-butene-1,4-diol, 1,5-pentanediol (pentamethylene glycol), 1,2-pentanediol, isoprene glycol (isopentyldiol), 1,2-hexane Dihydric alcohols such as diols, diethylene glycol, and dipropylene glycol;
Examples include trihydric alcohols such as glycerin and trimethylolpropane; and tetrahydric alcohols such as diglycerin, pentaerythritol, and 1,2,6-hexanetriol. Of these, 1,3-butylene glycol, glycerin (particularly concentrated glycerin), dipropylene glycol, 1,2-pentanediol, and 1,2-hexanediol are preferred.

  Examples of glycol ethers include diethylene glycol monomethyl ether, diethylene glycol monoethyl ether (ethoxydiglycol), diethylene glycol monopropyl ether, diethylene glycol monobutyl ether, diethylene glycol monoisobutyl ether, diethylene glycol dimethyl ether, ethylene glycol monobutyl ether, ethylene glycol monomethyl ether, ethylene Glycol monoethyl ether, triethylene glycol monobutyl ether, tetraethylene glycol monobutyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monopropyl ether, dipropylene glycol monomethyl ether , Dipropylene glycol monoethyl ether, dipropylene glycol monopropyl ether, and the like.

  The blending amount of the polyhydric alcohol and / or glycol ether in the external preparation for skin of the present invention is preferably 0.000001% by weight or more and 20% by weight or less, and preferably 0.00001% by weight or more and 10% by weight or less, from the viewpoint of reducing stickiness. % By weight or less is more preferable, 0.0001% by weight or more and 5.0% by weight or less is more preferable, and 0.001% by weight or more and 3.0% by weight or less is particularly preferable. In the present invention, polyhydric alcohols and / or glycol ethers may be used singly or in combination of two or more.

  Examples of the surfactant include nonionic surfactants, ionic surfactants (anionic surfactants, cationic surfactants, amphoteric surfactants) and the like.

Examples of the nonionic surfactant include sorbitan fatty acid esters such as sorbitan monoisostearate and sorbitan sesquioleate, glycerin fatty acid esters such as glyceryl monostearate, and propylene glycol fatty acid esters such as propylene glycol monostearate, Lipophilic nonionic surfactants such as polyglyceryl fatty acid esters such as polyglyceryl oleate, hydrogenated castor oil derivatives, glycerin alkyl ethers, polyoxyalkylene-modified silicones, both alkyl-polyoxyalkylene-modified silicones;
POE sorbitan fatty acid esters such as POE sorbitan monostearate, POE sorbite fatty acid esters such as POE sorbite monooleate, POE glycerin fatty acid esters such as POE glycerin monoisostearate, POE such as POE stearyl ether, POE cholestanol ether POE alkylphenyl ethers such as alkyl ethers, POE nonylphenyl ethers, pullaronic types such as pluronics, POEs such as POE / polyoxypropylene (hereinafter abbreviated as POP) cetyl ethers, tetra-POEs such as tetronics・ Tetra POP ethylenediamine condensate, POE castor oil, POE castor oil hardened castor oil derivatives such as POE hardened castor oil, POE beeswax lanolin derivative, a Hydrophilic properties such as canolamide, POE propylene glycol fatty acid ester, POE alkylamine, POE fatty acid amide, sucrose fatty acid ester, POE nonylphenyl formaldehyde condensate, polyoxyalkylene modified organopolysiloxane, alkylethoxydimethylamine oxide, trioleyl phosphate Nonionic surfactants and the like can be mentioned.

Examples of the ionic surfactant include polyoxyalkylene alkyl (or alkenyl) ether sulfate, alkyl (or alkenyl) sulfate, higher fatty acid salts (particularly palmitic acid, lauric acid, myristic acid, stearic acid, etc.) Salt of higher fatty acid), ether carboxylate, amide ether carboxylate, alkyl phosphate ester salt, N-acyl amino acid salt (sodium N-lauroyl aspartate, potassium hydroxide / N-coconut oil fatty acid potassium acyl glutamate, palm Anionic surfactants such as oil fatty acid acylglycine sodium and myristoyl glutamic acid), polyoxyalkylene fatty acid amide ether sulfate, acylated isethionate, and acylated taurate;
Cationic surfactants such as mono- or di-long-chain alkyl quaternary ammonium salts having a linear or branched long-chain alkyl group, to which an alkylene oxide may be added; and carbobetaines, sulfobetaines, imidazoles Examples include amphoteric surfactants such as nium betaine and amide betaine.

  Among these, nonionic surfactants are preferable, and polyglyceryl oleate (particularly polyglyceryl oleate 4) is preferably used from the viewpoint of good stability.

  The blending amount of the surfactant in the external preparation for skin of the present invention is preferably 0.000001% by weight or more and 10% by weight or less, from 0.00001% by weight to 5.0% by weight, from the viewpoint of the stabilizing effect of hyaluronic acid. The following is more preferable, 0.0001% by weight to 3.0% by weight is further preferable, and 0.001% by weight to 2.0% by weight is particularly preferable. In addition, in this invention, surfactant may be used individually by 1 type or may be used in combination of 2 or more type.

  As the liquid oil, it is preferable to use an oil that exhibits a liquid state at 25 ° C., for example, rapeseed oil, avocado oil, almond oil, olive oil, kukui nut oil, sesame oil, wheat germ oil, rice germ oil, rice bran oil, rice oil , Safflower oil, sunflower oil, soybean oil, evening primrose oil, corn oil, rapeseed oil, persic oil, palm oil, palm kernel oil, castor oil, jojoba oil, grape seed oil, macadamia nut oil, meadow foam oil, menthol oil Vegetable oil such as palm oil and rosehip oil; animal oil such as liquid horse oil, mink oil and liquid lanolin; liquid paraffin, light liquid isoparaffin, heavy liquid isoparaffin, liquid isoparaffin, polybutene, polyisobutene, squalane, squalene, α-olefin Oligomers, isohexadecane, isododecane, etc. Chain or branched hydrocarbon oils; higher fatty acids such as oleic acid and isostearic acid; higher alcohols such as isostearyl alcohol, octyldodecanol and hexyldecanol; alkyl glyceryl ethers such as isostearyl glyceryl ether; isopropyl myristate, myristic acid Ester oils of linear fatty acids and lower alcohols such as butyl, isopropyl palmitate, ethyl stearate, butyl stearate, ethyl oleate, ethyl linoleate, isopropyl linoleate; cetyl caprate, hexyl laurate, decyl myristate, S of linear fatty acid and linear higher alcohol such as myristyl myristate, cetyl myristate, cetyl palmitate, stearyl stearate, decyl oleate, oleyl oleate, etc. Oil: Sisostearyl laurate, isotridecyl myristate, isocetyl myristate, isostearyl myristate, octyldodecyl myristate, 2-ethylhexyl palmitate, isocetyl palmitate, isostearyl palmitate, 2-ethylhexyl stearate, isocetyl stearate Ester oils of linear fatty acids such as isodecyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate and the like, and branched chain alcohols such as ethyl isostearate and isopropyl isostearate Ester oil; cetyl 2-ethylhexanoate, cetostearyl 2-ethylhexanoate, stearyl 2-ethylhexanoate, hexyl isostearate, isostearic acid 2 -Ester oil of fatty acid having branched chain such as hexyldecyl and linear higher alcohol; ethylene glycol dioctanoate, ethylene glycol dioleate, propylene glycol dicaprylate, propylene glycol di (caprylic acid / capric acid), propylene glycol dicaprate , Dipropylene glycol dioleate, neopentyl glycol dicaprate, neopentyl glycol dioctanoate, glyceryl tricaprylate, glyceryl tri-2-ethylhexanoate, glyceryl tri (capryl / caprate), glyceryl triisopalmitate, glyceryl triisostearate , Tri-2-ethylhexanoic acid trimethylolpropane, triisostearic acid trimethylolpropane, tetra-2-ethylhexanoic acid pentaerythritol , Ester oils of fatty acids and polyhydric alcohols such as tetraisostearate pentaerythritol and tetra-2-ethylhexanoate pentaerythritol; octyldodecyl neopentanoate, isocetyl octoate, isostearyl octoate, 2-ethylhexyl isoperargonate, dimethyl Ester oil of branched fatty acid and branched chain alcohol such as hexyldecyl octoate, octyldodecyl dimethyloctanoate, 2-ethylhexyl isopalmitate, isocetyl isostearate, isostearyl isostearate, octyldodecyl isostearate, lactic acid Lauryl, myristyl lactate, cetyl lactate, octyl dodecyl lactate, trioctyl citrate, triisocetyl citrate, trioctyl dodecyl citrate, dii malate Ester oils having hydroxyl groups such as stearyl; dibasic ester oils such as dioctyl succinate, diisopropyl adipate, diisobutyl adipate, dioctyl adipate, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate; methyl polysiloxane, dimethyl Silicone oils such as polysiloxane, dimethylcyclopolysiloxane, decamethylcyclopentasiloxane, methylphenylpolysiloxane, methylhydrogenpolysiloxane, higher alcohol-modified silicone oil; fluorine oils such as fluoropolyether and perfluoroalkylether silicone Can be mentioned.

  Among these liquid oils, cetyl 2-ethylhexanoate, decamethylcyclopentasiloxane, pentaerythritol tetra-2-ethylhexanoate, glyceryl tri-2-ethylhexanoate, glyceryl tri (capryl / capric acid), meadowfoam oil, It is preferable to use one or more selected from squalane and jojoba oil.

  The blending amount of the liquid oil component in the external preparation for skin of the present invention is preferably 0.000001% by weight to 30% by weight, and preferably 0.00001% by weight to 20% by weight from the viewpoint of balance between stickiness and moisture retention. More preferably, 0.0001 wt% or more and 10 wt% or less is more preferable, and 0.001 wt% or more and 5.0 wt% or less is particularly preferable. In addition, in this invention, a liquid oil component may be used individually by 1 type, or may be used in combination of 2 or more type.

  Examples of the cell activation component include components derived from hydrolyzed proteins (eg, collagen), plants (eg, soybean, bilberry); amino acids such as γ-aminobutyric acid and ε-aminoproic acid; retinol and its Derivatives, thiamine, riboflavin, pyridoxine hydrochloride, and vitamins such as pantothenic acids; α-hydroxy acids such as glycolic acid and lactic acid; tannins, flavonoids, saponins, allantoins, and photosensitizer 301. Among these, hydrolyzed collagen, bilberry leaf extract, retinol, retinol acetate, and retinol palmitate are preferable.

  The blending amount of the cell activating component in the external preparation for skin of the present invention is preferably 0.000001% by weight or more and 10% by weight or less, and preferably 0.00001% by weight or more and 5.0% by weight from the viewpoint of appropriately improving the moisture retention. % Or less is more preferable, 0.0001 wt% or more and 3.0 wt% or less is more preferable, and 0.001 wt% or more and 2.0 wt% or less is particularly preferable. In addition, in this invention, a cell activation component may be used individually by 1 type, or may be used in combination of 2 or more type.

  Examples of the antibacterial component include chlorhexidine, benzalkonium chloride, acrinol, ethanol, benzethonium chloride, cresol, gluconic acid and derivatives thereof, popidone iodine, potassium iodide, iodine, isopropylmethylphenol, triclocarban, triclosan, and photosensitizer 101. No., Photosensitizer 201, paraben, phenoxyethanol, and alkyldiaminoglycine hydrochloride. Among these, benzalkonium chloride, benzethonium chloride, gluconic acid and its derivatives, isopropylmethylphenol, triclocarban, triclosan, photosensitizer 101, photosensitizer 201, paraben, phenoxyethanol, and alkyldiaminoglycine hydrochloride are preferable. More preferred are benzalkonium, gluconic acid and its derivatives, benzethonium chloride, and isopropylmethylphenol.

  Examples of the anti-inflammatory component include components derived from plants (eg, Comfrey); allantoin, calamine, glycyrrhizic acid or derivatives thereof, glycyrrhetinic acid or derivatives thereof, zinc oxide, guaiazulene, pyridoxine hydrochloride, turpentine oil, and the like. It is done. Among these, Comfrey leaf extract, allantoin, dipotassium glycyrrhizinate, and stearyl glycyrrhetinate are preferable.

  Examples of the anti-inflammatory analgesic component include: indomethacin; felbinac; ibuprofen; ibuprofen piconol; bufexamac; butyl fenfenamate; bendazac; piroxicam; ketoprofen and the like.

  Examples of the antipruritic component include crotamiton; chlorpheniramine; chlorpheniramine maleate; diphenhydramine; diphenhydramine hydrochloride; diphenhydramine salicylate; nonyl acid vanillyl amide; mequitazine; camphor; thymol; eugenol: polyoxyethylene lauryl ether;

Examples of the vitamins include retinol, retinol derivatives (eg, retinol acetate, retinol palmitate), retinal, retinoic acid, methyl retinoic acid, ethyl retinoic acid, retinol retinoic acid, d-δ-tocopheryl retinoate, α- Vitamin A such as tocopheryl retinoate and β-tocopheryl retinoate;
provitamins A such as β-carotene, α-carotene, γ-carotene, δ-carotene, lycopene, zeaxanthin, cryptoxanthin, and echinone;
Vitamin Es such as δ-tocopherol, α-tocopherol, β-tocopherol, dl-α-tocopherol succinate, dl-α-tocopherol calcium succinate, δ-tocopherol, and tocopherol nicotinate;
Vitamin B2 such as riboflavin, flavin mononucleotide, flavin adenine dinucleotide, riboflavin butyrate, riboflavin tetrabutyrate, sodium riboflavin 5′-phosphate, and riboflavin tetranicotinate;
Nicotinic acids such as methyl nicotinate, nicotinic acid, and nicotinamide;
Ascorbic acid, ascorbyl stearate, L-ascorbyl dipalmitate, ascorbyl tetraisopalmitate (ascorbyl tetra-2-hexyldecanoate), sodium ascorbate, dehydroascorbic acid, sodium ascorbate phosphate, magnesium ascorbate phosphate, And vitamin Cs such as ascorbic acid glucoside;
Vitamin Ds such as methyl hesperidin, ergocalciferol, and cholecalciferol;
Vitamin Ks such as phylloquinone and farnoquinone;
Dibenzoyl thiamine, dibenzoyl thiamine hydrochloride, thiamine hydrochloride, thiamine cetyl hydrochloride, thiamine thiocyanate, thiamine lauryl hydrochloride, thiamine nitrate, thiamine monophosphate, thiamine lysine salt, thiamine triphosphate, thiamine monophosphate Vitamins B1 such as phosphate, thiamine monophosphate, thiamine diphosphate, thiamine diphosphate hydrochloride, thiamine triphosphate, and thiamine triphosphate monophosphate;
Vitamin B6s such as pyridoxine hydrochloride, pyridoxine acetate, pyridoxal hydrochloride, 5'-pyridoxal phosphate, and pyridoxamine hydrochloride;
Vitamins B12 such as cyanocobalamin, hydroxocobalamin, and deoxyadenosylcobalamin;
Folic acids such as folic acid and pteroylglutamic acid;
Pantothenic acids, such as pantothenic acid, calcium pantothenate, pantothenyl alcohol (panthenol), D-pantethein, D-panthetin, coenzyme A, and pantothenyl ethyl ether;
And biotins such as biotin and biocytin; and vitamin-like agents such as carnitine, ferulic acid, α-lipoic acid, orotic acid, and γ-oryzanol.

  Among these, vitamin Cs such as sodium ascorbate phosphate, magnesium ascorbate phosphate, and ascorbyl tetraisopalmitate (ascorbyl tetra-2-hexyldecanoate) are preferable.

  Examples of the local anesthetic component include lidocaine, lidocaine hydrochloride, dibucaine, dibucaine hydrochloride, ethyl aminobenzoate, eucalyptus oil; eugenol, and chlorobutanol.

  Examples of the moisturizing component include components derived from plants (for example, Tigaya); amino acids such as alanine, serine, leucine, isoleucine, threonine, glycine, proline, hydroxyproline, glucosamine, and theanine and derivatives thereof; collagen, Proteins such as gelatin and elastin, peptides, or their hydrolysates; sugar alcohols such as sorbitol; phospholipids such as lecithin and hydrogenated lecithin; NMF such as lactic acid, sodium pyrrolidonecarboxylate, and urea Origin component; Polyglutamic acid; Polymer having phospholipid polar group such as MPC polymer (for example, LIPIDURE (registered trademark), etc.); Polyoxypropylene methyl glucoside; Trimethylglycine (betaine); Hydroxyethylurea; Acrylic acid acrylamide dimethyldiallylammonium chloride copolymer; and sorbitol.

  Among these, chigaya root extract, hydrolyzed collagen, hydrolyzed elastin, MPC polymer glycerin, trimethylglycine (betaine), hydroxyethylurea, acrylic acid / acrylamide / dimethyldiallylammonium chloride copolymer, hydrogenated lecithin, and sorbitol preferable.

  Examples of the whitening component include arbutin, hydroquinone, kojic acid, ellagic acid, phytic acid, lucinol, chamomile ET, ascorbic acid or a derivative thereof, vitamin E or a derivative thereof, pantothenic acid or a derivative thereof, tranexamic acid, and a whitening action. Plant components (for example, plant extracts and essential oils) having Among these, arbutin, hydroquinone, kojic acid, and tranexamic acid are preferable.

  Examples of the antioxidant component include components derived from plants (eg, grapes, ginseng, and comfrey); proanthocyanidins, tocopherols and derivatives thereof, ascorbic acid derivatives, hesperidin, glucosyl hesperidin, ergothioneine, sodium bisulfite, sodium bisulfite Erythorbic acid and salts thereof, flavonoids, glutathione, glutathione peroxidase, glutathione-S-transferase, catalase, superoxide dismutase, thioredoxin, taurine, thiotaurine, and hypotaurine.

  Among these, grape seed extract, grape leaf extract, ginseng extract, comfrey leaf extract, proanthocyanidins, tocopherol and its derivatives (particularly δ-tocopherol and α-tocopherol), ascorbic acid derivatives (particularly ascorbic acid phosphate) Sodium ester, magnesium ascorbate phosphate, and ascorbyl tetraisopalmitate (ascorbyl tetra-2-hexyldecanoate), hesperidin, glucosyl hesperidin, and ergothioneine are preferred.

  Examples of the anti-aging component include hydrolyzed soy protein, retinoid (retinol and derivatives thereof, retinoic acid, retinal, etc.), pangamic acid, kinetin, ursolic acid, turmeric extract, sphingosine derivative, silicon, silicic acid, N- Examples include methyl-L-serine and mevalonolactone. Among these, artemia extract, hydrolyzed soy protein, retinol, retinol acetate, and retinol palmitate are preferable.

  Examples of the keratin soft component include lanolin, urea, phytic acid, lactic acid, lactate, glycolic acid, malic acid, and citric acid. Among these, lactic acid, sodium lactate, glycolic acid, and phytic acid are preferable.

  Examples of the blood circulation promoting component include plants (e.g., ginseng, ashitaba, arnica, ginkgo, fennel, entomop, dutch oak, chamomile, roman chamomile, carrot, gentian, burdock, rice, hawthorn, shitake, hawthorn, papaver, Senkyu, assembly, thyme, clove, chimpi, spruce, spruce, spruce, carrot, garlic, butcher bloom, grapes, buttons, maronier, melissa, yuzu, yokuinin, rosemary, rosehip, chimpi, spruce, spruce, peach, apricot , Walnuts, corn and the like); tocopherol nicotinate, glucosyl hesperidin, hesperidin and the like.

  Among these, ginseng extract, tocopherol nicotinate, glucosyl hesperidin, and hesperidin are preferable.

  Examples of the component having an action of preventing and / or repairing DNA damage include, for example, a component derived from an animal (for example, Artemia), a component derived from a plant (for example, cat's claw), and DNA, a DNA salt, Examples of the nucleic acid component include RNA and RNA salts. Among these, artemia extract and DNA-Na are preferable.

  Examples of the ultraviolet absorbing component include 2-methoxyhexyl paramethoxycinnamate, 2- [4- (diethylamino) -2-hydroxybenzoyl] benzoic acid hexyl ester, 2,4,6-tris [4- (2- Ethylhexyloxycarbonyl) anilino] -1,3,5-triazine, dimethoxybenzylidene oxoimidazolidinepropionate 2-ethylhexyl, and 2,4-bis-[{4- (2-ethylhexyloxy) -2-hydroxy} -phenyl ] -6- (4-methoxyphenyl) -1,3,5-triazine and the like.

  Among these, 2-methoxyhexyl paramethoxycinnamate, 2- [4- (diethylamino) -2-hydroxybenzoyl] benzoic acid hexyl ester, and 2,4,6-tris [4- (2-ethylhexyloxycarbonyl) Anilino] -1,3,5-triazine is preferred.

  Examples of the ultraviolet scattering component include inorganic compounds such as zinc oxide, titanium oxide, iron oxide, cerium oxide, zirconium oxide, titanium silicate, zinc silicate, anhydrous silicic acid, cerium silicate, and hydrous silicate. These inorganic compounds are coated with inorganic powders such as hydrous silicic acid, aluminum hydroxide, mica, or talc, and these inorganic compounds are compounded with resin powders such as polyamide, polyethylene, polyester, polystyrene, or nylon. And those obtained by treating or coating these inorganic compounds with silicone oil, fatty acid aluminum salts, or the like.

  Among these, inorganic compounds such as zinc oxide, titanium oxide, and iron oxide, these inorganic compounds treated or coated with inorganic powders such as aluminum hydroxide, hydrous silicic acid, mica, or talc, or silicone oil Is preferred.

  Examples of the astringent component include metal salts such as alum, chlorohydroxyaluminum, aluminum chloride, allantoin aluminum salt, zinc sulfate, and potassium aluminum sulfate; and organic acids such as tannic acid, citric acid, lactic acid, and succinic acid. Can be mentioned. Among these, alum, chlorohydroxyaluminum, aluminum chloride, allantoin aluminum salt, aluminum potassium sulfate, and tannic acid are preferable.

  Examples of the hair-restoring ingredients include procyanidins, dipotassium glycyrrhizinate, capronium chloride, cephalanthin, menthol, hinokitiol, L-hydroxyproline, acetylhydroxyproline, fucoidan, capsicum tincture, cephalanthin, swellthianin, symphunginicin, flavonosteroid, minoxidil, FGF- 10, Enmiso extract (extract), assembly extract (extract), beetle extract (extract), amachazuru extract (extract), hypericum extract (extract), gentian extract (extract), sage extract (extract) , Peppermint extract (extract), hop extract (extract), yokuinin extract (extract), persimmon leaf extract (extract), ginger extract (extract), carrot extract (extract), bo Schima wallichii extract (extract), moutan bark extract (extract), Jiyu extract (extract) and the like.

  Examples of the antihistamine component include ethanolamine compounds such as diphenhydramine, diphenhydramine hydrochloride, and dimenhydrinate; propylamine compounds such as chlorpheniramine maleate; phenothiazine compounds such as promethazine hydrochloride; piperazine compounds such as hydroxyzine; In addition to piperidine compounds such as cyproheptadine hydrochloride, epinastine hydrochloride, loratadine, and fexofenadine hydrochloride are exemplified. In addition to the hydrochloride, pharmaceutically acceptable salts of the respective compounds can also be used. Among these, diphenhydramine, diphenhydramine hydrochloride, and chlorpheniramine maleate are preferable.

  Examples of the antiseptic component include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, butyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, benzyl paraoxybenzoate, Examples include methyl paraoxybenzoate and phenoxyethanol. Among these, methyl paraoxybenzoate, propyl paraoxybenzoate, and phenoxyethanol are preferable.

  In the external preparation for skin of the present invention, known additives that are added to pharmaceuticals, quasi drugs, or cosmetics within a range that does not impair the effects of the present invention, such as stabilizers, antioxidants, colorants, A pearl luster imparting agent, a dispersing agent, a chelating agent, a pH adjusting agent, a preservative, a thickener, an irritation reducing agent, and the like can be added.

  These additives can be used alone or in combination of two or more. Further, the following additives that correspond to a plurality of components exhibit the action as the corresponding plurality of components, but may not have a plurality of actions in a predetermined case.

  Examples of the stabilizer include sodium polyacrylate, dibutylhydroxytoluene, butylhydroxyanisole and the like.

  Examples of the antioxidant include dibutylhydroxytoluene, butylhydroxyanisole, sorbic acid, sodium sulfite, erythorbic acid, and L-cysteine hydrochloride.

  Examples of the colorant include inorganic pigments and natural pigments.

  Examples of the pearl luster imparting agent include ethylene glycol distearate, ethylene glycol monostearate, and triethylene glycol distearate.

  Examples of the dispersant include sodium pyrophosphate, sodium hexametaphosphate, polyvinyl alcohol, polyvinyl pyrrolidone, methyl vinyl ether / maleic anhydride crosslinked copolymer, and organic acid.

  Examples of the chelating agent include EDTA · disodium salt and EDTA · calcium disodium salt.

  Examples of the pH adjuster include inorganic acids (hydrochloric acid, sulfuric acid, etc.), organic acids (lactic acid, sodium lactate, citric acid, sodium citrate, succinic acid, sodium succinate, etc.), inorganic bases (potassium hydroxide, water, etc.). Sodium oxide), organic bases (triethanolamine, diisopropanolamine, triisopropanolamine, etc.).

  Examples of the preservative include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, butyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, and paraoxybenzoic acid. Examples include benzyl, methyl paraoxybenzoate, and phenoxyethanol.

  Examples of the thickener include cellulose-based thickeners such as methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, carboxyethylcellulose, guar gum, pectin, pullulan, gelatin, locust bean Gum, carrageenan, agar, xanthan gum, polyvinyl alcohol, polyvinyl pyrrolidone, carboxyvinyl polymer, alkyl methacrylate copolymer, polyethylene glycol, bentonite, alginic acid, propylene glycol alginate, macrogol, (hydroxyethyl acrylate / acryloyldimethyltaurine Na) copolymer, (acryloyldimethyl) Taurine ammonium / vinylpyrrolidone) copolymer, and the like.

  Examples of the irritation reducing agent include licorice extract, sodium alginate, gum arabic, polyvinylpyrrolidone, licorice extract, sodium alginate and the like.

<Form of external preparation for skin>
The external preparation for skin of the present invention comprises the essential components and the optional components described above together with a base or carrier usually used for pharmaceuticals, quasi drugs, or cosmetics, and, if necessary, additives described later. It can mix according to a conventional method and can be used as the skin external preparation of the formulation form of a pharmaceutical, a quasi-drug, or cosmetics.

  As the base or carrier, in addition to [A] petrolatum, hydrocarbons (excluding petrolatum) such as liquid paraffin, squalane, gelled hydrocarbon (such as plastibase), ozokerite, α-olefin oligomer, and light liquid paraffin; Methylpolysiloxane, highly polymerized methylpolysiloxane, cyclic silicone, alkyl-modified silicone, amino-modified silicone, polyether-modified silicone, polyglycerin-modified silicone, silicone-alkyl chain co-modified polyether-modified silicone, silicone-alkyl chain co-modified polyglycerin Silicone oils such as modified silicone, polyether-modified branched silicone, polyglycerin-modified branched silicone, acrylic silicone, phenyl-modified silicone, silicone resin; coconut oil, olive oil, rice bran oil, Fats and oils such as butter; waxes such as jojoba oil, miw wax, candelilla wax, lanolin; higher alcohols such as cetanol, cetostearyl alcohol, stearyl alcohol, behenyl alcohol, octyldodecanol, isostearyl alcohol, phytosterol, cholesterol; ethyl cellulose, hydroxy Cellulose derivatives such as propylcellulose and hydroxypropylmethylcellulose; polyvinylpyrrolidone; carrageenan; polyvinylbutyrate; polyethylene glycol; dioxane; butylene glycol adipic acid polyester; diisopropyl adipate, isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, palmitic acid Cetyl, isononyl isononanoate, tetra-2-ethylhex Esters such as pentaerythritol sanlate; polysaccharides such as dextrin and maltodextrin; vinyl polymers such as carboxyvinyl polymer and alkyl-modified carboxyvinyl polymer; lower alcohols such as ethanol and isopropanol; water and the like .

  When the external preparation for skin of the present invention contains components other than water as a base or carrier in addition to petrolatum, as such a base or carrier, higher alcohols, fats and oils, esters, silicone oils, waxes are preferable. Higher alcohols, ester oils, and silicone oils are more preferable. Among these components, cetanol, cetostearyl alcohol, stearyl alcohol, behenyl alcohol, glyceryl tri-2-ethylhexanoate, dimethicone, cyclomethicone, polyether-modified silicone, and polyglycerin-modified silicone are more preferable.

  When the skin external preparation of the present invention contains water, its content in the skin external preparation (100 wt%) of the present invention is preferably 0.00001 wt% to 49.9 wt%, preferably 0.001 wt% to 45 wt% is more preferable, 0.001 wt% to 40 wt% is further preferable, and 0.01 wt% to 30 wt% is particularly preferable.

  The bases or carriers described above can be used singly or in combination of two or more, and the amount used thereof is appropriately selected from a range known to those skilled in the art.

  The form of the external preparation for skin of the pharmaceutical preparation is not particularly limited, and examples thereof include an ointment, an emulsifier (emulsion and cream), a gel, and a liniment. These preparations can be manufactured according to the method described in the 16th revised Japanese Pharmacopoeia General Rules for Preparations.

  The form of the external preparation for skin of a quasi-drug or cosmetic preparation is not particularly limited, and examples thereof include emulsions, creams, gels, ointments, hand creams, body creams, lip balms and the like. These preparations can be manufactured according to a conventional method.

<Method for preparing external preparation for skin>
The method for preparing the external preparation for skin of the present invention is not particularly limited, and in addition to the essential components, optional components and various components necessary for producing a normal external preparation for skin (the above-mentioned base or carrier, additives, etc.) It can be produced by a conventional method by appropriately selecting and blending.

  EXAMPLES Hereinafter, although an Example demonstrates this invention in detail, this invention is not limited by these. The unit of the numerical value is% by weight unless otherwise specified.

<Preparation of external preparation for skin>
According to the formulation shown in Table 1 below, the skin external preparations of Example 1 and Comparative Examples 1 to 3 were prepared by a conventional method. That is, the gel phase prepared to have a constant viscosity was put into petrolatum and mixed. Each skin external preparation was evaluated by conducting the following tests. In addition, the skin external preparation containing petrolatum was prepared as Comparative Examples 1-3, and the skin external preparation which did not contain petrolatum and used only water as a base material as Reference Examples 1-3 was prepared.

<Tack test>
0.135 g of each of the skin external preparations of Example 1 and Comparative Examples 1 to 3 was uniformly applied to a 30φ circular rotor, and a foam physical property tester (Bubble Tester, Model: TB-1T, manufactured by Techno Hashimoto Co., Ltd.) was used. The pulling stress was measured and used as an index of tackiness (stickiness, adhesiveness). In addition, each test was implemented by n = 4, and the average value of the obtained numerical value (maximum value) was shown in the following Table 2.

  As shown in Table 2, when the hyaluronic acid Na is added (Example 1) compared to the case of Vaseline alone (Comparative Example 1), the pulling stress is reduced, and tackiness (stickiness, adhesiveness) is reduced. I found out. When other polymer thickeners were used in place of Na hyaluronate (Comparative Examples 2 and 3), the degree was lower than that of Petrolatum alone (Comparative Example 1) (Comparative Examples 2 and 3). ).

  As described above, it was shown that hyaluronic acid Na has an effect of remarkably improving the tackiness of the petrolatum preparation. That is, it was found that even a skin external preparation containing petrolatum at a high concentration can suppress stickiness and oiliness during application by blending Na hyaluronate.

<Sensory test>
After washing both inner forearms, 0.05 g of each external preparation for skin was applied in a 2 cm × 7 cm frame, and the feeling of use was evaluated for the following evaluation items. Each evaluation was a five-level evaluation based on the criteria shown below. Each test was performed with n = 5, and the average value of the obtained scores is shown in Table 3 below. About the external preparation for skin containing petroleum jelly (Example 1, Comparative Examples 1-3), the result was also shown in FIGS.

<Evaluation items and evaluation criteria>
(1) [Spread]: Bad spread = 1 point, Slightly slow stretch = 2 points, Normal = 3 points, Slight stretch is good = 4 points, Stretch is good = 5 points (2) [Skin familiarity]: Skin Unfamiliar = 1 point, slightly unfamiliar skin = 2 points, normal = 3 points, slightly good skin familiarity = 4 points, good skin familiarity = 5 points (3) [freshness]: not freshness = 1 point , Not very fresh = 2 points, normal = 3 points, slightly fresh = 4 points, fresh = 5 points (4) [sticky]: very sticky = 1 point, sticky = 2 points, slightly sticky = 3 points, normal = 4 Points, not sticky = 5 points (5) [shine]: very shining = 1 point, shining = 2 points, slightly shining = 3 points, normal = 4 points, not shining = 5 points (6 ) [Moist feeling]: not moist = 1 point, not very moist = 2 points, normal = 3 , A little moist = 4 points, to moist = 5 points

  As shown in Table 3, when Vaseline alone (Comparative Example 1) is combined with Vaseline and Na hyaluronate (Example 1), high scores are obtained in all evaluation items, and the feeling of use is remarkable. Improvement was seen. Further, in place of Na hyaluronic acid, when some thickeners and petrolatum were combined (Comparative Examples 2 and 3), a slight improvement effect was seen, but when compared with the skin external preparation of Example 1, The effect was slight. In particular, the sticky improvement effect which is the subject of the present invention was low. Furthermore, in Example 1, the moist feeling improvement effect was remarkable, while in Comparative Examples 2 and 3, there was almost no effect.

  For reference, the gel phase evaluation results that do not contain petrolatum at all are also shown, although problems such as stickiness due to the use of high-concentration petrolatum did not occur. In the case of hyaluronic acid (Reference Example 1), it was confirmed that the feeling of use was not particularly excellent compared to the case of using other polymer thickeners (Reference Examples 2 and 3). Nonetheless, when petrolatum and hyaluronic acid are used in combination, the use feeling of petrolatum is noticeably improved by hyaluronic acid (comparison using petrolatum and other polymer thickeners in combination) In Examples 2 and 3, there is not much improvement in the feeling of use). From this, the effect of improving the feeling of use of petrolatum by hyaluronic acid is an effect specific to hyaluronic acid that occurs when used in combination with petrolatum. Was suggested. This effect of improving the feeling of use of petrolatum by hyaluronic acid is an effect that has not been known so far, which the present inventors have found. Moreover, in the moisture retention (moist feeling) which is one of the effects of petrolatum, Reference Examples 1 to 3 were significantly inferior to Example 1. Therefore, the skin external preparation of Example 1 containing petrolatum in a high concentration and further containing sodium hyaluronate sufficiently solves problems such as stickiness and shine while maintaining the effects such as moisturizing property (moist feeling) of petrolatum. It was solved.

  External preparations for skin having the compositions shown in Tables 4 to 6 (Prescription Examples 1 to 14) were prepared by a conventional method. In any of the prescription examples, stickiness was reduced and the feeling of use was excellent.

  ADVANTAGE OF THE INVENTION According to this invention, although it contains petrolatum in high concentration, it is non-sticky and can provide the skin external preparation excellent in the usability | use_condition. The external preparation for skin of the present invention has good spread on the skin and is well-familiar with the skin, and it is also difficult to cause shine, and the skin after application can be fresh and moisturized. It can be used widely as a product, a cosmetic, and the like.

Claims (2)

[A] 50.0% by weight or more and 99.9% by weight or less of petroleum jelly,
[B] containing at least one component selected from the group consisting of sodium hyaluronate, hydrolyzate of hyaluronic acid, and acetylated hyaluronic acid (excluding those chemically bonded to the base powder) , Topical skin preparation (excluding allergic rhinitis coating). The external preparation for skin according to claim 1 , which is an ointment, an emulsifier or a gel.