JP6612155B2 - Syringe - Google Patents

Description

  The present invention relates to a syringe for injecting a substance to be injected into an injection target area of an object.

  Regardless of the presence or absence of the injection needle, in the syringe, injection of the injection solution is realized by pressurizing the injection solution. For example, in a needleless syringe that performs injection without going through the injection needle, An explosive may be used as a pressurization source (for example, refer to patent documents 1). In the needleless syringe shown in Patent Document 1, a detonator and a pyrotechnic charge are provided, and a hammer strikes the detonator and the detonator ignites, whereby the thermal energy is transmitted to the pyrotechnic charge. Then, the pyrotechnic is burned and pressurization to the injection solution is performed. As such a pyrotechnic, a single powder based on nitrocellulose is used.

  In addition, the combustion energy of explosives is used as a power source for pressurization even in a field different from that of a syringe. For example, Patent Document 2 discloses a technique relating to an actuator for driving a control member through a film using the combustion energy of explosives and blocking a medium flow in a flow path. In this technique, the elastically deformable film sandwiched between the control member and the housing is deformed by receiving the combustion pressure of the explosive, and the cylinder member attached to the film is displaced to drive the control member. Is.

JP-T-2004-532049 US Pat. No. 6,399,595

  When using the combustion energy of explosives as a power source for pressurization, it is necessary to consider the influence of combustion products such as combustion gas and combustion residue generated by the combustion. For example, when explosives are used as a pressurizing source of an injection solution in a syringe, it is not preferable in terms of hygiene that a combustion product is mixed into an injection target substance such as an injection solution to be pressurized.

  On the other hand, the elastically deformable membrane as in the prior art distinguishes between the space where the explosives are burned and the space where the pressurized object is placed, and the combustion energy of the explosives through the deformation of the membrane. When the pressure is transmitted to the object to be pressurized, the film is suddenly elastically deformed during combustion. And in order to displace the pressurization object by the required distance by pressurization, it is necessary to ensure the deformation amount according to the required distance in the deformation. For this reason, in the prior art, it is necessary for the film to be greatly elastically deformed toward the control member by the combustion of the explosive, and there is a concern that the film may be broken or cleaved. If the membrane is damaged, it is difficult to seal the combustion products in the space where combustion is performed. In addition, there is a possibility that sufficient transmission of combustion energy to the control member is hindered by the presence of the film.

  Therefore, in view of the above-described problems, the present invention suppresses the action of combustion products generated by explosive combustion on an injection target substance in a syringe that injects an injection target substance such as an injection liquid by explosive combustion, and the injection. The purpose of this is to transmit the energy for injection to the injectable substance.

  In order to solve the above-mentioned problems, the present invention provides a sealing member that divides a space in a syringe body into an ignition device side and a first piston part side. The structure sealed in the space of the side was employ | adopted. With such a configuration, it is possible to prevent combustion products from being mixed into the injection target substance. Further, the contact portion of the sealing member with the first piston portion is changed from the starting position on the ignition device side to the injection position on the syringe portion side with respect to the fixed end portion of the sealing member by combustion in the ignition device. A moving configuration was adopted. With such a configuration, it is difficult for the sealing member to be broken while suitably securing the amount of movement of the first piston portion.

  Specifically, the present invention is a syringe for injecting an injection target substance into a region to be injected, and the syringe body having a through hole formed in the axial direction and the inside of the through hole are slidably arranged. A first piston portion; a syringe portion disposed on a distal end side of the syringe body; a storage chamber capable of storing the injection target substance; and the injection in the storage chamber as the first piston portion slides A plunger for pressurizing the liquid target substance; and a flow path through which the injection target substance in the storage chamber pressurized by the plunger flows, and the injection target substance is ejected from an ejection port formed at a tip of the flow path A syringe part having a nozzle part, and an ignition device for burning explosives, wherein the first piston part has injection energy for injecting the injection target substance from the nozzle part by the explosive combustion in the ignition device Give Combustion generated by dividing the fire device and the space in the syringe body into a first space in which the ignition device is disposed and a second space in which the first piston portion is disposed. And a sealing member that seals an object in the first space. The first piston portion has a plunger-side end portion that contacts the plunger, and a predetermined end portion having a predetermined end surface that receives the injection energy, and the sealing member is disposed in the syringe body. A fixed end portion fixed to an inner wall that defines a space of the first end portion, and a contact portion that contacts the predetermined end surface of the predetermined end portion during explosive combustion in the ignition device. Further, in a state before the explosive combustion in the ignition device, the contact portion is positioned at a starting position on the ignition device side with respect to the fixed end portion, and the contact portion is caused by the explosive combustion in the ignition device. The first end portion is in contact with the predetermined end surface and is moved to the injection position on the syringe portion side with respect to the fixed end portion as the first piston portion slides.

  In the syringe according to the present invention, the contact portion of the sealing member is moved from the starting position to the injection position by the injection energy generated by the explosive combustion in the ignition device, and in the course of the movement, the predetermined end surface of the first piston portion and The first piston part slides in the through hole. Then, by applying pressure to the injection target substance accommodated in the storage chamber of the syringe part by sliding the first piston part, the injection target substance is injected from the injection port to the outside of the syringe. The In addition, if the movement of the contact portion in the sealing member is caused by the combustion of the explosive, a configuration in which the injection energy is directly applied to the first piston portion through the contact portion, or the injection energy is temporarily changed to another gas. It is possible to appropriately employ a configuration in which the first piston part is indirectly acted on via the contact part after propagating to liquid, solid or the like.

  Injectable substances contain components that are expected to be effective inside the injection target area. If injection by injection energy is possible, the injectable substance is contained in a syringe, or is in a liquid or gel form. The specific physical form of the injection target substance such as fluid, powder, and granular solid is not limited. The injection target substance includes a component to be sent to the injection target region of the living body, which is the target, and the component may exist in a state dissolved in the injection target substance, or the component may be dissolved. Instead, it may be simply mixed. For example, as ingredients to be delivered, there are vaccines for antibody enhancement, proteins for cosmetics, cultured cells for hair regeneration, etc., so that these can be injected into fluids such as liquids and gels. By inclusion, a substance for injection is formed. In addition, the syringe may be of a type that supplies a substance to be injected to the injection target region via a needle, or may be a type that is supplied without a needle.

  Here, in the syringe according to the present invention, the ignition device for burning the explosive means that the ignition powder accommodated in the ignition device is ignited by the execution of the ignition device, and a combustion product of the ignition powder is generated. Alternatively, a known gas generating agent (for example, a single base smokeless explosive) is further combusted by ignition of the igniting agent, and a combustion product of the igniting agent and the gas generating agent is generated. Well, in the syringe of the present invention, the specific configuration of the ignition device is not limited.

  When explosives burn in such an igniter, the combustion products diffuse into the space inside the syringe body, and generally the injection energy is transmitted to the first piston part via pressure, heat, etc. As described above, it becomes a power source for injection of the injection target substance. Here, since the syringe according to the present invention is provided with a sealing portion, the combustion product is sealed in the first space and does not enter the second space. Therefore, an undesirable effect on the injection target substance by the combustion product can be suppressed. And in order to acquire the sealing effect, it is necessary for a sealing member to have a certain amount of resistance with respect to combustion of explosives, On the other hand, by providing a sealing member, to the 1st piston part of injection energy. It is not preferred that the transmission of is inhibited. Therefore, the sealing member needs to satisfy both the suitable sealing of the combustion product and the suitable transmission of the injection energy to the first piston part.

  Therefore, the sealing member is configured such that the contact portion of the first piston portion moves from the starting position on the ignition device side to the injection position on the syringe portion side with respect to the fixed end portion fixed to the inner wall of the space in the syringe body. It is configured to move in contact with a predetermined end face. With such a configuration, after the explosive combustion, the sealing member is deformed so that the contact portion is turned over with respect to the fixed end portion, and the sliding of the first piston portion is promoted. For this reason, unlike the conventional technique, the sealing member is not greatly stretched only in one direction during explosive combustion, and the sealing member is not easily damaged. Further, when the above-described inverted structure is adopted, when the first piston portion slides, the moving range of the contact portion is from the starting position on the ignition device side to the injection position on the syringe portion side with respect to the fixed end portion. While the amount of movement of the contact portion corresponding to the sliding distance of the first piston portion for injection of the target substance is ensured, the sealing member does not need to be greatly deformed. Transmission is less likely to be disturbed. This contributes to both suitable sealing of the combustion products and suitable transmission of the injection energy to the first piston part.

  In the syringe according to the present invention, the sealing member may be formed of an elastic member. As a result, the sealing member extends at the time of explosive combustion in the igniter, so that both the sealing of the combustion product and the transmission of the injection energy to the first piston part are more preferably achieved.

  Further, the sealing member covers a side surface portion of the predetermined end portion along the sliding direction of the first piston portion in a state before the explosive combustion in the ignition device, and the fixed end portion and the contact portion In this case, the intermediate portion extends in the sliding direction as the first piston portion slides due to the explosive combustion in the ignition device. The contact portion is configured to move from the start position to the injection position. In the syringe configured as above, the contact portion moves and the first piston portion is propelled while the intermediate portion of the sealing member extends in the sliding direction of the first piston portion. The part is given a sliding amount corresponding to the extension. By such an action, the injection energy by the explosive combustion is suitably used for propelling the first piston part, and the sliding amount of the first piston part for pressurizing the injection target substance is suitably ensured. It becomes possible. In addition, since the intermediate portion extending in the sliding direction of the first piston portion is formed by the elastic member, the intermediate portion can be flexibly extended, and as a result, the sealing member is hardly damaged.

In the syringe, an outer diameter of the first piston portion at the predetermined end may be smaller than an inner diameter of the through hole. In that case, the intermediate portion extends in the sliding direction along the inner wall surface of the through hole as the first piston portion slides due to the explosive combustion in the ignition device. According to such a configuration, the first piston portion has a gap in the radial direction with respect to the through hole in the vicinity of the predetermined end portion. And when a contact part moves by combustion of explosive, since an intermediate part can be expanded using the said clearance gap, it becomes easy to perform extension of this intermediate part smoothly. As a result, it is possible to suitably ensure the sliding amount of the first piston part that pressurizes the injection target substance, and it is possible to avoid damage to the sealing member.

  Further, in the syringe up to the above, the second piston part further slidable in the through hole and disposed on the first space side, wherein the contact part of the sealing member is the first piston. You may further provide the 2nd piston part arrange | positioned on both sides with the said predetermined end surface of a part. In that case, the second piston portion is opposed to the ignition device, and the ignition device side end portion to which the injection energy is input, and the injection energy is applied to the predetermined end surface of the first piston portion through the contact portion. A first piston portion side end portion for transmission.

  In the syringe configured as above, the injection energy from the ignition device is received by the ignition device side end portion of the second piston portion, and the first piston portion side end portion is the other end portion. The injection energy is transmitted to the predetermined end face of the first piston part through the contact part of the sealing member sandwiched between the second piston part. Therefore, the sealing member does not directly receive the injection energy from the ignition device but receives it through the second piston member. As a result, during explosive combustion, the contact portion is not directly exposed to the high-temperature and high-pressure combustion product, so that the sealing member including the contact portion can be more reliably avoided from being damaged. Further, since the contact portion is sandwiched between the first piston portion and the second piston portion, the force for turning the sealing member upside down as described above can be appropriately applied to the sealing member. The sliding of the first piston part can be expected.

  According to the present invention, in a syringe that injects an injection target substance such as an injection solution by explosive combustion, the action of the combustion product generated by the explosive combustion on the injection target substance is suppressed, and energy for injection is preferably used. It is possible to communicate to the injection target substance.

It is a figure showing a schematic structure of a syringe concerning a 1st embodiment of the present invention. It is a figure which shows the detail of the piston of the syringe shown in FIG. It is a figure which shows schematic structure of the initiator (ignition apparatus) with which the syringe shown in FIG. 1 is mounted | worn. In the syringe shown in FIG. 1, it is a figure which compares and shows the state before the explosive combustion in an initiator, and the state after combustion. It is a figure which shows schematic structure of the syringe which concerns on 2nd Embodiment of this invention.

  Hereinafter, a needleless syringe 1 having no needle (hereinafter simply referred to as “syringe 1”) will be described as an example of a syringe according to an embodiment of the present invention with reference to the drawings. In addition, the structure of the following embodiment is an illustration and this invention is not limited to the structure of these embodiment.

<First Embodiment>
Fig.1 (a) is sectional drawing of the syringe 1, FIG.1 (b) is the figure which looked at the syringe 1 from the nozzle part 9 side which inject | emits an injection solution. In the following description of the present application, injection target substances that are injected into the injection target area of the target by the syringe 1 are collectively referred to as “injection solution”. However, this is not intended to limit the content or form of the injected substance. In the injection target substance, the component to be delivered to the skin structure may or may not be dissolved, and the injection target substance can be injected from the nozzle portion 9 to the skin structure by pressurization. Then, the specific form is not ask | required and various forms, such as a liquid, a gel form, and a powder form, are employable.

  Here, the syringe 1 has a syringe body 2 composed of a first housing 3 and a second housing 4, and is connected to the distal end side of the syringe body 2 (the second housing 4 is connected to the first housing 3. The syringe part 5 is arrange | positioned in the edge part side on the opposite side to the edge part which is present. The first housing 3 and the second housing 4 are fixed together with screws and integrated. Here, a combustion chamber 31, which is an internal space extending in the axial direction, is formed inside the first housing 3, and in the second housing 4 in the same axial direction. A through hole 37 that is an extending internal space is formed. Although the combustion chamber 31 and the through hole 37 are separated by a sealing member 8 to be described later, the combustion chamber 31 and the through hole 37 are internal spaces arranged continuously in the syringe body 2.

  Moreover, the syringe part 5 provided in the front end side of the syringe main body 2 has the syringe part main body 11 which has the storage chamber 33 which accommodates the injection solution ML inside, the nozzle part 9 in which the flow path through which an injection solution flows was formed, And a nozzle holder 10 provided with a nozzle portion 9. The nozzle holder 10 is attached to the syringe unit body 11 by a holder cap 12 with a gasket 13 in between. Moreover, the syringe part main body 11 is screwed and attached to the end part of the second housing 4 of the syringe main body 2, and the through hole 37 in the second housing 4 and the syringe part main body 11 in the attached state. The inner chamber 33 is a continuous space. In the attached state, the injection liquid ML is liquid-tightly stored in the storage chamber 33 by the plunger 7, and the plunger 7 is exposed to the through hole 37 side. Here, the plunger 7 is disposed so as to be slidable in the storage chamber 33, and further, pressurizes the injection liquid ML by sliding, so that the injection liquid is ejected from the nozzle portion 9. Further, the plunger 7 is formed of a rubber member having a surface coated with a thin silicone oil so that the plunger 7 can slide smoothly in the storage chamber 33.

  Next, a metal piston 6 is disposed in the through hole 37 in the second housing 4 of the syringe body 2, and the piston 6 is slidably held in the through hole 37. Here, the details of the piston 6 are shown in FIG. 2 so that the positional relationship with the housing 4 can be grasped. The piston 6 is formed in a substantially axial shape extending along the axial direction of the through hole 37, and has an end portion on the combustion chamber 31 side (hereinafter referred to as “first end portion”) 6 a and an end on the syringe portion 5 side. Part, that is, an end part (hereinafter referred to as “second end part”) 6 b that contacts the plunger 7 disposed in the syringe part 5, and the piston 6 can smoothly slide in the through hole 37. In addition, an O-ring 6 c is disposed around the piston 6. Here, the first housing 3 (indicated by a dotted line in FIG. 2) and the second housing 4 are attached to form the syringe body 2, and before the explosive combustion is performed by the initiator 20 which is an ignition device described later. In the state (hereinafter referred to as “pre-ignition state”), the first end 6 a is connected to the combustion chamber 31 from the end face of the fitting portion 4 a of the second housing 4 fitted in the combustion chamber 31 of the first housing 3. It is in a state of substantially protruding to the side. Further, the diameter d1 of the first end 6a is smaller than the diameter d0 of the through hole 37. Therefore, when the piston 6 slides in the through-hole 37 toward the syringe part 5, it is constant between the side surface of the first end 6 a (the surface along the axial direction of the piston 6) and the inner wall surface of the through-hole 37. The gap is formed.

  Here, in the state before ignition shown in FIG. 1, the sealing member 8 is fixed on the end surface of the fitting portion 4 a of the second housing 4, which is a part of the inner wall of the syringe body 2, The space inside the syringe body 2 is made of an elastic material, and includes a space including the combustion chamber 31 located on the initiator 20 side (corresponding to the first space according to the present invention) and a through hole 37 located on the piston 6 side. The combustion product generated by explosive combustion in the initiator 20 is sealed in the combustion chamber 31 by dividing into a space (corresponding to the second space according to the present invention). The details of the structure of the sealing member 8 and the operation by the explosive combustion in the initiator 20 will be described later.

  Here, an example of the initiator 20 will be described with reference to FIG. The initiator 20 is an electric ignition device, and a space for arranging the ignition agent 22 is defined in the cup 21 by a cup 21 whose surface is covered with an insulating cover. And the metal header 24 is arrange | positioned in the space, and the cylindrical charge holder 23 is provided in the upper surface. The charge holder 23 holds the ignition agent 22. A bridge wire 26 that electrically connects one conductive pin 28 and the metal header 24 is wired at the bottom of the ignition agent 22. The two conductive pins 28 are fixed to the metal header 24 via the insulator 25 so that they are insulated from each other when no voltage is applied. Furthermore, the opening of the cup 21 from which the two conductive pins 28 supported by the insulator 25 extend is protected by the resin collar 27 in a state in which the insulation between the conductive pins 28 is well maintained.

  In the initiator 20 configured as described above, when a voltage is applied between the two conductive pins 28 by the external power source, a current flows through the bridge wire 26, thereby burning the igniting agent 22. At this time, the combustion products resulting from the combustion of the igniting agent 22 are ejected from the opening of the charge holder 23. The initiator cap 14 is formed in a hook shape so as to be caught on the outer surface of the initiator 20, and is screwed to the first housing 3. As a result, the initiator 20 is fixed to the first housing 3 by the initiator cap 14, and thus it is possible to prevent the initiator 20 itself from dropping from the syringe body 2 due to the pressure generated when the initiator 20 is ignited.

  Here, the igniting agent 22 used in the syringe 1 is preferably an explosive containing zirconium and potassium perchlorate (ZPP), an explosive containing titanium hydride and potassium perchlorate (THPP), titanium and potassium perchlorate. Explosives containing aluminum (TiPP), explosives containing aluminum and potassium perchlorate (APP), explosives containing aluminum and bismuth oxide (ABO), explosives containing aluminum and molybdenum oxide (AMO), explosives containing aluminum and copper oxide ( ACO), explosives containing aluminum and iron oxide (AFO), or explosives composed of a combination of these explosives. These explosives generate high-temperature and high-pressure plasma at the time of combustion immediately after ignition, but exhibit a characteristic that the generated pressure rapidly decreases because the combustible organisms do not contain gas components when they become room temperature. In addition, you may use explosives other than these as an ignition powder.

  Here, nothing is arranged in the combustion chamber 31 shown in FIG. 1, but a gas generating agent that generates gas by burning with combustion products generated by the combustion of the igniting agent 22 is arranged in the combustion chamber 31. You may do it. Assuming that a gas generating agent is disposed in the combustion chamber 36, an example thereof is a single base smokeless explosive comprising 98% by mass of nitrocellulose, 0.8% by mass of diphenylamine, and 1.2% by mass of potassium sulfate. It is also possible to use various gas generating agents that are used in gas generators for airbags and gas generators for seat belt pretensioners. The combined use of such a gas generating agent is different from the case of only the igniting agent 22 described above, and the predetermined gas generated at the time of combustion contains a gas component even at room temperature, so the rate of decrease in generated pressure is small. Further, the combustion completion time at the time of combustion of the gas generating agent is extremely longer than that of the igniting agent 22, but the size, size and shape of the gas generating agent when disposed in the combustion chamber 36, particularly the surface By adjusting the shape, it is possible to change the combustion completion time of the gas generating agent. Thus, by adjusting the amount, shape, and arrangement of the gas generating agent, the generated pressure in the combustion chamber 36 can be adjusted as appropriate.

A plurality of nozzle portions 9 may be formed on the nozzle holder 10 or one nozzle portion 9 may be formed. When a plurality of nozzle portions are formed, a flow path corresponding to each nozzle portion is formed so that the injection solution ML released to each nozzle is fed as evenly as possible. Furthermore, when a plurality of nozzle portions 9 are formed, it is preferable that the nozzle portions are arranged at equal intervals around the central axis of the syringe 1 as shown in FIG. Further, the flow path diameter of the nozzle portion 9 is configured to be smaller than the inner diameter of the through hole 37. Thereby, the injection pressure of the injection solution at the time of injection can be raised suitably.

  Here, the detail of the sealing member 8 in the state before ignition is demonstrated. As shown in FIG. 1, the sealing member 8 is formed so as to cover the first end 6 a of the piston 6 that protrudes toward the combustion chamber 31. Specifically, the sealing member 8 includes a fixed end portion 35 fixed on the fitting portion 4a of the second housing 4 and a contact portion positioned so as to contact the end surface of the first end portion 6a and cover the end surface. 34 and an intermediate portion 36 that is formed between the contact portion 34 and the fixed end portion 35 and is positioned so as to cover the side surface portion of the first end portion 6a. Therefore, as shown in FIG. 1, in the cross section along the axial direction of the syringe 1, the sealing member 8 is formed in a U shape, and the contact portion 34 corresponding to the bottom surface of the sealing member 8 is in relation to the fixed end portion 35. It is located at the starting position on the initiator 20 side (left side as viewed in FIG. 1).

  Here, the movement of the sealing member 8 when the ignition agent 22 of the initiator 20 burns and the injection state of the injection solution in the syringe 1 will be described with reference to FIG. FIG. 4 shows the configuration of the syringe 1 in the pre-ignition state in the upper stage, and the configuration of the syringe 1 in the state where injection of the injection solution is completed by the combustion of the ignition agent 22 (hereinafter referred to as “injection completed state”) in the lower stage. Show. In the comparison between the pre-ignition state and the injection completion state in FIG. 4, the positions of the fixed end portions 35 of the sealing member 8 are aligned, and both states are displayed side by side in the axial direction of the syringe 1. The position of the fixed end 35 common to both states is indicated as X0, and the reference line including the position X0 is indicated as L0.

  Further, in the pre-combustion state, the position of the contact portion 34 is indicated by X1, which is the position on the initiator 20 side with respect to the position X0 as described above. Further, the position of the plunger 7 at this time is indicated by P1. Here, when the igniting agent 22 burns, the combustion product diffuses into the combustion chamber 31 and the pressure in the combustion chamber 31 increases. Thereby, the pressure is also applied to the sealing member 8. In particular, the pressure that presses the piston 6 toward the syringe part 5 is the pressure applied to the piston 6 via the contact part 34 in the sealing member 8. It is. Therefore, the end surface of the first end portion 6a of the piston 6 with which the contact portion 34 contacts is an end surface that receives the injection energy from the initiator 20.

  Thus, the contact part 34 is a part which transmits the injection energy produced | generated by combustion of the ignition agent 22 among the sealing members 8 to the piston 6 side. As a result, in the sealing member 8, the contact portion 34 moves to the syringe portion 5 side and the piston 6 slides in the through hole 37. As the piston 6 slides, the plunger 7 presses the injection liquid ML, and as a result, the injection liquid ML is ejected from the nozzle portion 9 to the injection target area. Here, in the injection completion state in which the injection of the injection liquid ML is completed, the contact portion 34 is in contact with the end surface of the first end portion 6a of the piston 6 as shown in the lower part of FIG. Since it is in contact with the inner wall surface of the nozzle holder 10 on which 9 is formed, sliding of the piston 6 is limited. The position of the contact portion 34 in this state is an injection position, indicated by X2, and is a position on the syringe unit 5 side with respect to the position X0. The position of the plunger 7 is indicated by P2.

Thus, in the syringe 1, in the process of burning the igniting agent 22, the contact portion 34 of the sealing member 8 moves from the start position X1 in the pre-combustion state to the injection position X2 in the injection completion state. The movement distance (X2-X1) due to the movement of the contact portion 34 corresponds to the movement distance (P2-P1) of the plunger 7 for injecting the injection liquid ML. With this movement, the sealing member 8 is deformed so as to be turned over. That is, the moving distance of the piston 6 and the plunger 7 necessary for injecting the injection liquid ML is ensured by the reverse deformation of the sealing member 8. When the sealing member 8 is deformed so that it is turned over in this way, the sealing member 8 itself does not need to be greatly elastically deformed, and the displacement of the intermediate portion 36 and the contact portion 34 except the fixed end portion 35 is mainly used. Even if the intermediate portion 36 is extended as a result of the contact portion 34 being largely displaced toward the syringe portion 5 due to the injection energy generated by the combustion of the igniting agent 22, the intermediate portion 36 is first shown in the upper part of FIG. It moves to the syringe part 5 side from the state shown in this, and it expand | extends with the displacement of the contact part 34 after that. Therefore, it is possible to suppress the elastic deformation amount of the intermediate portion 36 itself, and it is possible to suppress the damage of the sealing member 8 while ensuring a sufficient movement distance of the plunger 7 for injection of the injection liquid ML. . Thereby, it becomes possible to keep the combustion product from being sufficiently mixed into the injection solution by the sealing member 8 sufficiently.

  Further, as described above, the diameter d1 of the first end 6a of the piston 6 is configured to be smaller than the inner diameter d0 of the through hole 37. Therefore, when the above-described deformation of the sealing member 8 is reversed, the intermediate portion 36 enters the gap between the first end portion 6 a and the through hole 37, and the deformation is reversed along the inner wall surface of the through hole 37. And it becomes possible to perform extension smoothly. The contact portion 34 is not necessarily in contact with the end surface of the first end portion 6a of the piston 6 when in the injection position, as long as the piston 6 is slid for injection of the injection liquid ML. The contact portion 34 may be in a non-contact state with the end face when it reaches the injection position.

Second Embodiment
FIG. 5 shows a second embodiment of the present invention. In the first embodiment, the energy emitted from the initiator 20 is applied to the piston 6 via the sealing member 8, and the sealing member 8 is directly exposed to the combustion gas. On the other hand, in the present embodiment, the injection energy is once propagated to the piston 60 and then indirectly acts on the piston 6 via the sealing member 8, and the sealing member 8 is directly exposed to the combustion products. Can be suppressed. In the present embodiment, the syringe body 2 is formed by the first housing 3A and the second housing 4, and the same reference numerals are given to the substantially same configurations as those in the first embodiment. Detailed description thereof is omitted.

  A combustion chamber 31 is formed in the first housing 3 </ b> A, and the combustion product from the initiator 20 is configured to diffuse into the combustion chamber 31. Here, a metal piston 60 is further disposed in the combustion chamber 31, and is slidably held in the combustion chamber 31. The piston 60 is arranged so that one end thereof faces the initiator 20 and the other end sandwiches the contact portion 34 of the sealing member 8 with the first end 6 a of the piston 6. Therefore, when the ignition agent 22 is burned by the operation of the initiator 20, the injection energy is input to the end portion of the piston 60 facing the initiator 20, and then transmitted to the piston 6 via the contact portion 34 of the sealing member 8. Go. Therefore, the piston 6 slides together with the piston 60 by the combustion of the igniting agent 22. Also at this time, the sealing member 8 is deformed to be reversed as in the first embodiment. In particular, in the present embodiment, since the contact portion 34 is sandwiched between the piston 6 and the piston 60, the deformation of the sealing member 8 is limited to a specific direction, and the above-described deformation is reversed. It becomes easy to be performed smoothly. In the present embodiment, since the injection energy is once input to the piston 60, the sealing member 8 can be prevented from being directly exposed to the combustion product, and as a result, the sealing member 8 is applied. Thermal stress can be reduced and the breakage can be more reliably suppressed.

<Example 1>
In the syringe 1 according to the first embodiment, a confirmation experiment was performed to confirm whether or not the sealing by the sealing member 8 is achieved during the explosive combustion in the initiator 20. The material of the sealing member 8 employs NBR (nitrile rubber) as a rubber material, and breaks the sealing member 8 when the hardness of the rubber material and the temperature condition of the syringe 1 during operation are changed. It was confirmed visually.

  Specifically, the hardness of the rubber material is two types of 50 degrees and 70 degrees. The temperature conditions of the syringe 1 are three types: high temperature (50 degrees), normal temperature (20 degrees), and low temperature (0 degrees). Furthermore, the pressure in the combustion chamber 31 at the time of explosive combustion is a peak value of 30 MPa, and the thickness of the sealing member 8 is 1 mm. Under the respective hardness and temperature conditions, the explosive combustion of the initiator 20 was performed three times, and the number of times that the sealing member 8 was damaged was confirmed. As a result, no damage was observed under all conditions.

<Example 2>
In the syringe 1 according to the second embodiment, a confirmation experiment was performed to confirm whether or not the sealing by the sealing member 8 is achieved during the explosive combustion in the initiator 20. The material of the sealing member 8 employs chloroprene and NBR as rubber materials, respectively, and visually checks for damage or the like in the sealing member 8 when the temperature conditions of the syringe 1 during operation are changed in each rubber material. Confirmed by

  Specifically, the hardness when chloroprene is adopted as the rubber material is 65 degrees, and the hardness when NBR is adopted is 70 degrees. The temperature conditions of the syringe 1 are three types: high temperature (50 degrees), normal temperature (20 degrees), and low temperature (0 degrees). Furthermore, the pressure in the combustion chamber 31 at the time of explosive combustion is a peak value of 30 MPa, and the thickness of the sealing member 8 is 1 mm. Under each rubber material and temperature condition, the explosive combustion of the initiator 20 was performed three times, and the number of times that the sealing member 8 was damaged was confirmed. As a result, no damage was recognized under all conditions.

  From the above, it can be understood that in any of the embodiments, NBR can be suitably employed as the rubber material forming the sealing member 8. In the second embodiment, chloroprene can be further used as the rubber material. In addition, the result of the said Example is an example to the last, By adjusting the hardness of a rubber material or limiting the temperature conditions of the syringe 1, chloroprene is used as the said rubber material also in 1st Embodiment. It is also possible to adopt it.

<Other examples>
According to the syringe 1 according to the present invention, in addition to the case where the above-mentioned injection solution is injected into the skin structure, for example, in the field of regenerative medicine for humans, the cells to be injected and the cultured cells in the scaffold tissue / scaffold It is possible to seed stem cells and the like. For example, as disclosed in JP-A-2008-206477, cells that can be appropriately determined by those skilled in the art depending on the site to be transplanted and the purpose of recellularization, such as endothelial cells, endothelial precursor cells, bone marrow cells, and prebones Blast cells, chondrocytes, fibroblasts, skin cells, muscle cells, liver cells, kidney cells, intestinal cells, stem cells, and other cells considered in the field of regenerative medicine can be injected with the syringe 1. . More specifically, the liquid (cell suspension) containing the cells to be seeded is accommodated in the accommodating chamber 33, and a predetermined cell is injected and transplanted into the site to be transplanted by pressurizing the liquid. .

  Furthermore, the syringe 1 according to the present invention can also be used for delivery of DNA or the like to cells, scaffold tissue, scaffolds, etc. as described in JP-T-2007-525192. In this case, it can be said that the use of the syringe 1 according to the present invention is more preferable than the case of delivery using a needle because the influence on the cells, the scaffold tissue, the scaffold and the like can be suppressed.

Furthermore, the syringe 1 according to the present invention is suitable also when various genes, tumor suppressor cells, lipid envelopes, etc. are directly delivered to a target tissue or when an antigen gene is administered to enhance immunity against a pathogen. Used for. In addition, in the field of various disease treatments (fields described in JP2008-508881, JP2010-503616, etc.), immunomedicine (fields described in JP2005-523679, etc.), etc. The syringe 1 can be used, and the field in which the syringe 1 can be used is not intentionally limited.

DESCRIPTION OF SYMBOLS 1 ... Syringe 2 ... Syringe main body 5 ... Syringe part 6 ... Piston 7 ... Plunger 8 ... Sealing member 9 ... Nozzle part 10 ... ··· Nozzle holder 11 ··· Filling case 20 ··· Initiator 22 ··· Ignition powder 31 ··· Combustion chamber 33 ··· Storage chamber 34 ··· Contact portion 35 ··· Fixed end 36 ... Intermediate part 37 ... Through hole 60 ... Piston

Claims (5)

A syringe for injecting an injection target substance into an injection target area,
A syringe body having a through hole formed in an axial direction;
A first piston portion slidably disposed in the through hole;
A syringe part disposed on the distal end side of the syringe body, wherein the injection target substance in the storage chamber is pressurized in accordance with sliding of the storage chamber capable of storing the injection target substance and the first piston part. A plunger, and a flow path through which the injection target substance in the storage chamber pressurized by the plunger flows, and a nozzle portion for injecting the injection target substance from an injection port formed at the tip of the flow path. A syringe part;
An ignition device that burns explosives, the ignition device imparting injection energy to the first piston portion for injecting the injection target substance from the nozzle portion by the explosive combustion in the ignition device;
A space in the syringe body is divided into a first space in which the ignition device is disposed and a second space in which the first piston portion is disposed, and combustion products generated by the ignition device are divided into the first space. A sealing member for sealing in one space;
With
The first piston portion has a plunger side end portion that contacts the plunger, and a predetermined end portion having a predetermined end surface that receives the injection energy,
The sealing member is
A fixed end fixed to an inner wall defining a space in the syringe body;
A contact portion that comes into contact with the predetermined end surface of the predetermined end portion during explosive combustion in the ignition device;
Have
In the state before the explosive combustion in the ignition device, the contact portion is located at a starting position on the ignition device side with respect to the fixed end portion,
By the explosive combustion in the ignition device, the contact portion is configured to come into contact with the predetermined end surface and move to the injection position on the syringe portion side with respect to the fixed end portion as the first piston portion slides. To be
Syringe. The sealing member is formed of an elastic member.
The syringe according to claim 1. The sealing member covers a side surface portion of the predetermined end portion along the sliding direction of the first piston portion in a state before explosive combustion in the ignition device, and between the fixed end portion and the contact portion. Further having an intermediate part formed in
As the first piston portion slides due to the explosive combustion in the ignition device, the contact portion moves from the starting position to the injection position while the intermediate portion extends in the sliding direction.
The syringe according to claim 2. The outer diameter of the first piston portion at the predetermined end is smaller than the inner diameter of the through hole,
As the first piston portion slides due to the explosive combustion in the ignition device, the intermediate portion extends in the sliding direction along the inner wall surface of the through hole.
The syringe according to claim 3. A second piston portion slidable in the through hole and disposed on the first space side, the contact portion of the sealing member being sandwiched with the predetermined end surface of the first piston portion A second piston portion disposed;
The second piston portion is opposed to the ignition device, and the ignition device side end portion to which the injection energy is input, and the injection energy is transmitted to the predetermined end surface of the first piston portion through the contact portion. A piston portion side end, and
The syringe according to any one of claims 1 to 4.

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