JP6664883B2 - External composition - Google Patents

Description

  The present invention relates to a composition for external use.

  Heparin-like substances have a moisturizing effect and a blood circulation promoting effect, and their usefulness for dry skin diseases and hypertrophic scars has been recognized in clinical tests. Therefore, heparin-like substances are blended in skin external preparations (cosmetics), pharmaceuticals and the like. However, symptoms such as dry skin, scars on the skin, and swelling of the skin due to bruising or spraining, which are treated by the heparin-like substance, may impair the soundness and beauty of the appearance.

  Heretofore, cosmetics containing a metal oxide and a heparin-like substance have been known (Patent Documents 1 and 2). In Patent Literature 1, heparin-like substances and metal oxides are blended with lip cosmetics such as lip colors for the purpose of improving skin roughness. Further, in Patent Document 2, a fatty acid metal soap is blended with a skin external preparation such as a lotion for the purpose of preventing sedimentation of metal oxide (caking phenomenon). However, these techniques are not topical compositions with a specific viscosity that include heparin analogs.

  Therefore, it is very important for an external composition to maintain the appearance of the skin with the external composition while improving the symptoms of dry skin and scarring caused by the heparin-like substance.

JP 2000-204020 A Patent No. 3670211

  An object of the present invention is to provide an external composition for improving the appearance of skin while improving the symptoms of dry skin and skin scars caused by heparin-like substances.

  The present inventors have conducted intensive studies in order to solve the above-mentioned problem, and used a metal oxide in combination with an external composition containing a heparin-like substance, and further reduced the viscosity of the external composition. By adjusting to the range, it has been found that metal oxides can maintain the beauty of skin appearance while improving the symptoms of dry skin and skin scars by the heparin-like substance.

  In addition, the present inventors have found that the portion to which the external composition is applied corrects the hue changed by redness or pigmentation of the skin, or the adhesive force of the external composition to the affected area is improved. I found that.

  The present invention has been completed based on these findings, and has the following embodiments.

Item 1.
An external composition comprising a heparin-like substance and a metal oxide and having a viscosity of 20,000 mPa · s to 1,000,000 mPa · s when measured at 25 ° C. using a B-type viscometer.

Item 2.
Item 2. The external composition according to Item 1, which is a hue corrector.

Item 3.
Item 3. The external composition according to Item 1 or 2, which is an emulsion composition.

  The composition for external use of the present invention has a specific viscosity and can improve the appearance of skin by metal oxide while improving symptoms of dry skin and skin scars by a heparin-like substance.

  In other words, in the area where the external composition of the present invention is applied, the hue changed by the redness of the skin and the pigmentation on the skin accompanying the symptoms of dry skin and skin scars, swelling and internal bleeding, is corrected. It can be less noticeable. In addition, when applied to the skin, the composition for external use of the present invention has good adhesion to the affected area.

  The composition for external use of the present invention is useful for metal oxide-containing preparations such as foundation and concealer-like cream preparations.

(1) External composition The external composition of the present invention contains a heparin-like substance and a metal oxide, and has a viscosity of 20,000 mPas to 1,000,000 mPas when measured at 25 ° C using a B-type viscometer. It is. The external composition is preferably an emulsion composition (cream or the like).

  Hereinafter, the viscosity of the composition for external use of the present invention and each component contained therein will be described.

(1-1) Viscosity The composition for external use of the present invention has a viscosity of 20,000 mPa · s to 1,000,000 mPa · s when measured at 25 ° C. using a B-type viscometer.

  The viscosity (25 ° C.) of the composition for external use of the present invention is more preferably about 50,000 mPa · s to 700,000 mPa · s, and still more preferably about 100,000 mPa · s to 550,000 mPa · s.

  This viscosity is measured at 25 ° C. using a B-type viscometer on a sample that has been allowed to stand for one day. For example, it can be measured with a RB-85L viscometer (single cylindrical rotary viscometer) manufactured by Toki Sangyo Co., Ltd. using a rotor with a rotor number of M4. Adjust between 0.3 rpm and 60 rpm depending on For example, 60 rpm for 10,000 mPas or less, 12 rpm for 10,000 mPas to 50,000 mPas, 1.5 rpm for 50,000 mPas to 400,000 mPas, and 400,000 mPas to 2,000,000 mPas In the case of, measure at 0.3 rpm. Note that the viscosity is a value 30 seconds after the start of the measurement.

  The composition for external use of the present invention becomes semi-solid, and the blending amount of water is preferably 10% by weight or more, more preferably 20% by weight or more. The semi-solid state indicates a state in which the fluidity is a little at normal temperature (15 ° C to 25 ° C). The semi-solid state is different from a solid state in that it does not show a fixed shape such as a stick-shaped cosmetic product, but changes its shape when touched with a finger and can be applied to a flat surface. Specifically, ointments, creams, gels, jellies, suspensions, emulsions and the like are preferred.

  Since the composition for external use of the present invention has a specific viscosity, when applied to the skin, it has good adhesion to the affected area.

(1-2) Heparin-like substance The heparin-like substance contained in the composition for external use of the present invention is a polysulfate ester of mucopolysaccharide, and should be one listed in the Japanese Pharmacopoeia Non-Pharmaceutical Standards (1993). Is preferred.

  Heparin-like substances, when the topical composition of the present invention is used as a cosmetic such as a concealer-like medicine or a foundation, has a skin moisturizing action and a blood circulation promoting action, and causes symptoms such as dry skin and skin scars. Can be improved. By incorporating a heparin-like substance in an external composition, it restores the barrier function of the skin, restores skin moisture, protects it from external stimuli (moisturizing action), activates skin metabolism, and promotes skin regeneration It can be expected to have an action (blood circulation promoting action), an action to suppress skin inflammation and bring rough skin to a normal state (anti-inflammatory action). As described above, the topical composition of the present invention can improve the symptoms of dry skin and skin scars by using a heparin-like substance.

  The content of the heparin-like substance in the composition for external use of the present invention can be appropriately selected depending on the type and the content of the metal oxide used in combination, preferably about 0.05 to 4% by weight, more preferably about 0.1 to 2% by weight. Is more preferable, and about 0.2 to 1% by weight is more preferable.

  The heparin-like substance is blended in the above-mentioned composition in the composition for external use of the present invention, and when the composition for external use is used as a concealer-like medicine or a cosmetic such as a foundation, it has a skin moisturizing effect and a blood circulation promoting effect. It can improve symptoms such as dry skin and scars on the skin. Furthermore, when used in combination with a metal oxide, the effect of the heparin-like substance and the effect of the metal oxide can be synergistically exhibited.

(1-3) Metal oxide The external composition of the present invention contains a metal oxide. When the composition for external use of the present invention is used as a concealer-like medicine or a cosmetic such as a foundation, the metal oxide functions as a coloring agent necessary for coloring the skin or a color-forming agent for the skin.

  The external use composition of the present invention can maintain the beauty of the skin appearance by the metal oxide. Further, in the portion to which the composition for external use of the present invention has been applied, the hue changed by the redness of the skin or the pigmentation on the skin accompanying the symptoms of dry skin and skin scars, swelling and internal bleeding, is corrected. It can be less noticeable.

  It is preferable to use iron oxide, white pigment, or the like as the metal oxide.

  When the external composition is used as a concealer-like medicine or a cosmetic such as a foundation, the iron oxide functions as a coloring agent necessary for coloring the skin.

  As the iron oxide, red iron oxide (iron sesquioxide, red iron oxide), yellow iron oxide, yellow iron sesquioxide, black iron oxide, or the like is preferably used. Red iron oxide (red iron oxide), yellow iron oxide and the like can adjust the color tone as a coloring pigment. One type of iron oxide may be used alone, or two or more types may be used in combination according to the application.

  The metal oxide preferably contains a white metal oxide (white pigment) in addition to the iron oxide. White pigments include, for example, color pigments, extender pigments and the like, and when the external composition is used as a cosmetic such as a concealer-like medicine or a foundation, it functions as a preparation agent for color development by the iron oxide on the skin. .

  As the white metal oxide, chromium oxide, zinc oxide (zinc white), titanium oxide, aluminum oxide, talc, crown talc, kaolin, or the like is preferably used. It is more preferable to use a metal oxide such as titanium oxide or crown talc as the white metal acid. White pigments such as titanium oxide and zinc oxide can be used not only to adjust the color but also to hide spots and freckles. Ultrafine particles such as titanium oxide and zinc oxide can also be used for protection against ultraviolet rays. Titanium oxide coated mica (titanium mica) can be used as a pearlescent pigment. In cosmetics, titanium oxide can be used as an ultraviolet scattering agent, as a sunscreen, a foundation, and the like. Talc can be used for adjusting gloss, feeling of use, and the like. The white metal oxide may be used alone or in combination of two or more according to its use.

  The particle size and shape of the metal oxide are not limited, and a conventionally known metal oxide can be appropriately used depending on the purpose. The particle size of the metal oxide is preferably about 0.01 to 10 μm, more preferably about 0.1 to 1 μm, and still more preferably 0.1 to 0.8 μm. The particle size of the metal oxide can be measured by laser diffraction or the like. The metal oxide is preferably in a powder form.

  The content of the metal oxide in the external use composition of the present invention (the total amount when two or more kinds are used in combination) can be appropriately selected depending on the content of the heparin-like substance used in combination, and 5 to 30% by weight. Degree is preferable, about 8 to 20% by weight is more preferable, and about 10 to 15% by weight is further preferable.

  The content of iron oxide in the composition for external use of the present invention (the total amount when two or more kinds are used in combination) can be appropriately selected, is preferably about 0.01 to 8% by weight, and is preferably about 0.1 to 5% by weight. More preferably, it is more preferably about 1 to 3% by weight.

  The content of the pigment (white pigment or the like) other than iron oxide in the external composition of the present invention (the total amount when two or more types are used in combination) can be appropriately selected depending on the type and content of the iron oxide. As a result, about 1 to 35% by weight is preferable, about 1 to 30% by weight is more preferable, and about 1 to 25% by weight is further preferable.

  The mixing ratio of the heparin-like substance and the metal oxide (total amount when two or more kinds are used in combination) in the composition for external use of the present invention is such that the metal oxide is 1.25 to 600 parts by weight per 1 part by weight of the heparin-like substance. It is preferable to mix the metal oxide in an amount of about 4 to 200 parts by weight, and it is more preferable to mix the metal oxide in an amount of about 10 to 75 parts by weight.

  The compounding ratio of the heparin-like substance and iron oxide in the composition for external use of the present invention is preferably about 0.0025 to 160 parts by weight of iron oxide with respect to 1 part by weight of the heparin-like substance. More preferably, about 50 parts by weight, more preferably about 1 to 15 parts by weight of iron oxide.

  When the composition for external use of the present invention is used for skin, the type and content of metal oxide (iron oxide, white pigment, etc.) can be appropriately selected according to the color of the skin to be applied.

(1-4) Other Components Blended in External Composition The external composition of the present invention may be composed of only an aqueous phase. Further, it is possible to use an aqueous phase when the external composition is used as an emulsified composition. The emulsified composition is formed from an aqueous phase and an oil phase.

Aqueous component The external composition of the present invention preferably contains water. The type of water is not particularly limited. For example, purified water, distilled water, ion-exchanged water, sterilized water, physiological saline, deep sea water, and the like can be used without limitation. Preferably, it is purified water.

  The content of water in the composition for external use of the present invention is preferably about 10 to 90% by weight, and more preferably about 20 to 80% by weight.

  The composition for external use of the present invention preferably contains a polyhydric alcohol. For example, it is preferable to use a polyhydric alcohol having 2 to 6 carbon atoms and 2 to 3 oxygen atoms. As polyhydric alcohols, ethylene glycol, diethylene glycol, propylene glycol, 1,3-propanediol, dipropylene glycol, 1,3-butylene glycol, 1,2-pentanediol, 1,2-hexanediol, 3-methyl-1 It is more preferable to use 1,3-butanediol, glycerin, sorbitol and the like. Among them, it is particularly preferable to use propylene glycol, dipropylene glycol, 1,3-butylene glycol, and 1,2-pentanediol. The polyhydric alcohols may be used alone or in combination of two or more.

  The content of the polyhydric alcohol in the composition for external use of the present invention is preferably about 1 to 10% by weight, and more preferably about 2 to 5% by weight.

Oily Component The external composition of the present invention preferably contains an oily component that is liquid at normal temperature (25 ° C.). Thereby, the external composition of the present invention becomes an emulsified composition obtained by mixing the aqueous phase and the oil phase.

  The oily component that is liquid at room temperature is not particularly limited as long as it is acceptable in the fields of pharmaceuticals, quasi-drugs, cosmetics, food and drink, and the like. For example, it is preferable to use an aliphatic alcohol that is liquid at room temperature. It is preferable to use a liquid alcohol such as hexyldecanol, octyldodecanol, decyltetradecanol, oleyl alcohol, or lauryl alcohol as the oily component that is liquid at room temperature. It is more preferable to use a liquid alcohol such as hexyldecanol and octyldodecanol, and it is even more preferable to use hexyldecanol.

  It is preferable to use a silicone oil, a mineral oil, a vegetable oil, a liquid wax or an ester oil as the oil component that is liquid at normal temperature.

  The oil component that is liquid at room temperature may be used alone or in combination of two or more.

  The content of the oily component that is liquid at room temperature in the external composition of the present invention is preferably about 1 to 30% by weight, more preferably about 5 to 20% by weight, and still more preferably about 10 to 15% by weight. When the oily component that is liquid at normal temperature in the external use composition is contained at this content, the emulsified state thereof is stabilized, and a good emulsified state can be maintained for a long period of time.

  It is preferable that the composition for external use of the present invention further contains an oily component which is solid at normal temperature (25 ° C.). Thereby, when the external composition of the present invention is used as an emulsified composition, the dispersibility of the metal oxide can be further improved, and the coloring property can be further improved. The oily component that is solid at room temperature functions as a base when the composition for external use is used as a concealer-like drug or cosmetic such as a foundation.

  The oily component that is solid at room temperature is not particularly limited as long as it is acceptable in the fields of pharmaceuticals, quasi-drugs, cosmetics, foods and beverages, and the like. For example, it is preferable to use an alcohol that is solid at room temperature.

  Fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, behenic acid, waxes such as beeswax, carbana wax, lanolin, lanolin ester, candelilla wax, cetostearyl alcohol, It is preferable to use solid alcohols such as stearyl alcohol, cetanol (cetyl alcohol), myristyl alcohol, isostearyl alcohol, behenyl alcohol, and lanolin alcohol. It is more preferable to use solid alcohols such as cetostearyl alcohol, stearyl alcohol, cetanol (cetyl alcohol), and behenyl alcohol.

  It is preferable to use hydrocarbon oils such as microcrystalline wax, α-olefin oligomer, gelled hydrocarbon, ceresin wax, solid paraffin, and petrolatum as an oily component that is solid at room temperature. Among them, it is preferable to use microcrystalline wax.

  The oil component that is solid at room temperature may be used alone or in combination of two or more.

  The content of the oily component that is solid at room temperature in the external composition of the present invention is preferably about 1 to 30% by weight, more preferably about 3 to 25% by weight, and still more preferably about 5 to 20% by weight. When the oily component that is solid at room temperature in the external composition is contained at this content, the emulsified state thereof is stabilized, and a good emulsified state can be maintained for a long period of time.

  The content (total amount) of at least one oil component selected from the group consisting of a liquid oil component and a solid oil component in the external composition of the present invention is about 1 to 60% by weight for the same reason as described above. Is preferably, about 5 to 40% by weight, more preferably about 10 to 35% by weight.

The composition for external use of the present invention such as a medicinal component, a surfactant, a stabilizer, and a preservative may also contain a desired medicinal component within a range that does not impair the effects of the present invention. Although there is no particular limitation on the medicinal component, it is preferable to use, for example, steroids, local anesthetics, anti-inflammatory agents, bactericides, antipruritics, skin protectants, blood circulation promoting components, vitamins, and the like.

  The composition for external use of the present invention may further contain a surfactant (glyceryl monostearate, polyoxyethylene behenyl ether, etc.), a thickener, and a stabilizer (edetic acid) as needed, as long as the effects of the present invention are not impaired. Sodium, etc.), absorption enhancers, adsorbents, fillers, antioxidants, preservatives (methyl paraoxybenzoate, propyl paraoxybenzoate, etc.), emulsifiers, solubilizers, bactericides, humectants, pH adjusters, fragrances , A deodorant, a dispersant, a pigment other than the metal oxide, bentonite, mica (mica) and the like. As the bentonite, it is preferable to use natural bentonite, bentonite subjected to ion exchange treatment, or the like.

  The pH of the composition for external use of the present invention is not particularly limited, and may be appropriately set according to the purpose of use. For example, when the composition for external use is applied to the skin, a pH in the range of weakly acidic to neutral is exemplified, and it is preferably pH 4.5 to 7 from the viewpoint of hypoallergenicity to the skin, and pH 4.5. More preferably, it is set to 6.5.

(2) Preparation method of the composition for external use The external composition of the present invention is prepared by mixing a heparin-like substance and a metal oxide as described above, and if the viscosity is 20,000 mPas to 1,000,000 mPas under the above measurement conditions, It can be manufactured according to a usual method in the art. The composition for external use of the present invention is preferably a semi-solid composition at 25 ° C.

  The types, contents, mixing ratios, and the like of the metal oxide, heparin-like substance, and other optional components used in the method for preparing the external composition are described in the same manner as described above. In the preparation of the composition for external use, it is preferable that the components are mixed and heated to a temperature of about 50 to 90 ° C., and then mixed under a predetermined condition using a mixer such as a homogenizer, a homomixer, and a stirrer. Thereby, an aqueous composition consisting of only an aqueous phase or an emulsified composition can be prepared by mixing and emulsifying an aqueous phase and an oil phase.

(3) Application target of the external composition The application target of the external composition of the present invention is not limited. For example, skin (including scalp) is preferable. When the composition for external use is intended to be applied to the skin or the like, it is sufficient that the viscosity can be applied within the range of 20,000 mPas to 1,000,000 mPas under the above measurement conditions, for example, cosmetics It is not limited as long as it is in the form of being applied to the skin, such as quasi-drugs for external use and medicaments for external use on the skin. For example, a form suitable for various desired external preparations such as an ointment, a cream, a paste, a mousse, a gel, a jelly, a suspension, and an emulsion is preferable. Since the external composition of the present invention has a specific viscosity, when applied to the skin, it has good adhesion to the affected area.

  The composition for external use of the present invention can improve symptoms of dry skin and scars on the skin with a heparin-like substance (moisturizing action, blood circulation promoting action, anti-inflammatory action, etc.). The external use composition of the present invention can maintain the beauty of the skin appearance by the metal oxide. The topical composition of the present invention is useful as a hue corrector because it can correct hue changed by redness of the skin or pigmentation on the skin.

  When the composition for external use of the present invention is used, for example, by applying it to human skin, the amount and the number of times of applying the composition for external use to skin are not particularly limited. For example, depending on the type and concentration of the physiologically active substance contained, the age of the user, gender, degree of symptoms, form of application, expected degree, etc., an appropriate amount of skin is applied once to several times a day. It is preferably applied to (particularly a site where a symptom occurs).

  The composition for external use of the present invention is useful for a metal oxide-containing preparation such as a foundation or a concealer-like cream preparation.

  The present invention will be specifically described based on examples, but the present invention is not limited to these.

(1) Preparation of foundation agent (emulsion composition) A foundation agent (emulsion composition) was prepared according to the formulation shown in Table 1 or 2.
Aqueous phase: First, each component (heparin-like substance, metal, etc.) described in Table 1 or 2 is weighed, heated and mixed in water at 80 ° C., and uniformly dissolved to prepare an aqueous composition. did.
Oil phase: Next, each blended component (liquid oil, solid oil, etc.) described in Table 1 or 2 was weighed, heated and mixed at 80 ° C., and uniformly dissolved to prepare an oily composition. .

  The oily composition and the aqueous composition were mixed and stirred to prepare an emulsified composition.

  This emulsified composition was used as a foundation agent (external composition).

  The foundation was creamy.

(2) Viscosity of foundation agent The viscosity of the emulsified composition was measured using a B-type viscometer (RB-85L viscometer, manufactured by Toki Sangyo Co., Ltd.) using a rotor having a rotor number of M4. At 25 ° C. The viscosity 30 seconds after the start of the measurement was adopted.

(3) Hue correction test for redness and pigmentation (quantitative evaluation 1)
Using the bioskin redness model, the degree of hue correction after application of the formulation was quantified by a spectrophotometer.
Equipment used: Spectrophotometer (Spectrophotometer CM-700d, manufactured by Konica Minolta, Inc.)
Bio Skin (Burelux Co., Ltd., 195 × 130 × 5Tmm plate type)
Coating method: 0.02 g of the foundation agent of each of Examples and Comparative Examples was placed on the bioskin, spread around 5 times by turning with an index finger, and gently tapping 20 times to make it adapt.
Measurement method: Hue (Hue) and lightness (Value) were measured using a spectrophotometer before and after application of each foundation agent.

  Table 3 summarizes the test method.

(4) Hue correction test for redness and pigmentation (quantitative evaluation 2)
Using the bioskin redness model, the hue correction power after application of the preparation, the adhesion of the preparation, and the uneven coating were evaluated and scored.
Equipment used: Spectrophotometer (Spectrophotometer CM-700d, manufactured by Konica Minolta, Inc.)
Application method: 0.02 g of the preparation was placed on the bioskin, spread around 5 times by turning it with the index finger, and gently tapped 20 times to make it fit.
Measurement method: Before and after application of each cream, measurement was performed using a spectrophotometer.

  The evaluation criteria are as follows.

(a) Evaluation of hue correction power A : Difference in ΔE before and after coating is 5 or more.
：: Difference in ΔE before and after coating is less than 5 and 4 or more.
Δ: Difference in ΔE before and after coating is less than 4 and 3 or more.
×: The difference of ΔE before and after coating is less than 3 and 2 or more.
-: The difference in ΔE between before and after coating is less than 2.

(b) Evaluation of adhesive force of preparation A : Neither touched nor adhered to finger, and could not be removed even if rubbed lightly.
：: Does not stick to fingers even when touched, and can be removed by lightly rubbing.
Δ: Slightly adheres to the finger when touched.
×: When touched, it sticks to the entire contact surface of the finger.
-: Wet and slippery when touched.

(c) Evaluation of coating unevenness ：: The maximum difference of ΔE when measured three times is 0.5 or less.
：: The maximum difference of ΔE when measured three times is 0.5 or more and less than 1.0.
Δ: The maximum difference of ΔE when measured three times is 1.0 or more and less than 1.5.
X: The maximum difference of ΔE when measured three times is 1.5 or more and less than 2.0.
−: The maximum difference of ΔE when measured three times is 2.0 or more.

(d) Conversion of evaluation of each item into points
The evaluations of the items (a) to (c) were converted into scores.
Score 3: “◎” is “good”.
Score 2: "○" is "somewhat good".
Score 1: "△" is "neither".
Score 0: “x” is “slightly bad”, and “−” is “bad”.

(e) Comprehensive evaluation
The total points of the items (a) to (c) were calculated.
◎: 8 points or more ○: 7.9 points to 6 points △: 5.9 points to 4 points ×: 3.9 points to 2 points −: Less than 2 points

  When Examples 1 to 9 and Comparative Examples 1 to 9 are compared, the foundation agents (external compositions) of Examples 1 to 9 have a specific viscosity and include a heparin-like substance and a metal oxide. It was found that hue changed by redness or pigmentation could be corrected. In addition, it was found that the foundation agents of Examples 1 to 9 can be applied to the skin without coating unevenness, and have excellent adhesion to the applied portions.

  As described above, the use of the composition for external use of the present invention makes it possible to maintain the appearance of the skin by the metal oxide while improving the symptoms of dry skin and scarring on the skin with a heparin-like substance. The composition for external use of the present invention is useful for metal oxide-containing preparations such as foundation and concealer-like cream preparations.

Formulation Examples Formulation examples of the same foundation agent (external composition) as in Example 1 above are shown (Table 9).

  Both have specific viscosities and, by containing a heparin-like substance and a metal oxide, have desired effects in terms of hue correction, uneven coating, and adhesion to a coated portion.

Claims (4)

Include heparinoid and metal oxides, using a B-type viscometer, Ri viscosity 20,000mPa · s~1,000,000mPa · s der in when measured at 25 ° C.,
Hue correction agent der Ru external composition (however, 70% or less b except foundation formulations of maltitol aqueous solution 5 parts by weight Glycerin 5 parts by weight 1,3-butylene glycol 5 parts by weight methyl paraben 0.2 parts by weight of butyl paraben 0 1 part by weight rotriglycerin diisostearate 5 parts by weight Liquid paraffin 12 parts by weight Light isoparaffin 8 parts by weight Microcrystalline wax 4 parts by weight neopentyl glycol diisooctanoate 4 parts by weight 26.5 parts by weight Heparin-like substance 0.1 parts by weight iron-doped titanium dioxide 10 parts by weight zirconium-doped titanium dioxide 2 parts by weight iron oxide 3 parts by weight talc 5 parts by weight water 5 parts by weight lipase 0.1 part by weight). Including a heparin-like substance and a metal oxide,
The metal oxide contains iron oxide and titanium oxide, with respect to 1 part by weight of the heparin-like substance, the metal oxide is 1.25 to 75 parts by weight,
An external composition having a viscosity of 20,000 mPa · s to 1,000,000 mPa · s when measured at 25 ° C. using a B-type viscometer. The composition for external use according to claim 2, which is a hue corrector. The external composition according to any one of claims 1 to 3, which is an emulsion composition.