JP6715641B2 - Aqueous bactericidal composition - Google Patents

Description

The present invention relates to an aqueous bactericidal composition obtained by blending a fragrance having bactericidal activity in an aqueous solution.

In recent years, in place of pathogenic bacteria, which have been regarded as a problem in the past, varieties of bacteria commonly found in the living environment have become a problem. For example, MRSA is a strain of Staphylococcus aureus that is commonly found in human wounds and the like and has acquired a high degree of drug resistance. Escherichia coli 0157 is a variant of Escherichia coli commonly found in the human intestine. And produces Shigella-like toxins.

In order to disinfect and sterilize such bacteria, a spray type bactericide containing ethanol as a bactericidal component is widely used. However, since ethanol is flammable, it has been necessary to be careful when using it in places where fire is used, such as around kitchens. In addition, when a sterilizing agent containing ethanol is applied to a resin member, there is a possibility that peeling of the coating or wax may occur, and it is difficult to use for those who do not like the smell of ethanol or those who have rough hands with ethanol. There was also. Furthermore, since food and tableware are present around the kitchen, there is a demand for a highly safe bactericide that does not affect health even if it adheres to them.

Therefore, various bactericides which are used as food additives and contain a highly safe fragrance component as a bactericidal component have been proposed. For example, Patent Document 1 discloses a disinfecting composition in which a flavor component having bactericidal activity and citric acid or salicylic acid as an organic acid for adjusting pH are blended, and thymol is blended as a flavor component. Is listed. Further, Patent Document 2 discloses an antibacterial flavor composition containing a flavor component and fumaric acid or fumaric acid ester or lactate ester.

Special table 2002-511391 gazette Japanese Patent Publication No. 2002-528566

By the way, since the fragrance component is generally sparingly soluble or insoluble in water, it is necessary to add a large amount of a solvent or a surfactant in order to mix it with an aqueous preparation. However, when a large amount of solvent is blended, there are problems that the coating applied to the surface of the resin member, wax, etc. may be peeled off, or the bactericide itself may easily catch fire. On the other hand, when a large amount of a surfactant is blended, the surfactant tends to remain after the germicide is wiped off, and there are problems such as leaving a wiping mark and the necessity of double wiping.

Among the perfume ingredients having bactericidal activity, thymol and carvacrol are dissolved in water in a small amount, and therefore can be incorporated into an aqueous preparation. However, thymol and carvacrol have a peculiar odor, and when the blending amount is large, the odor causes a bad feeling in use, and when the blending amount is reduced to reduce the odor, the bactericidal effect is weakened. ..

In view of the above problems, the present invention aims to provide an aqueous bactericidal composition capable of maintaining a sufficient bactericidal effect while suppressing the odor by suppressing the amount of thymol and carvacrol which are bactericidal components to be mixed in water. And

To achieve the above object, the present invention comprises dissolving at least one selected from thymol and carvacrol and at least one selected from fumaric acid and phytic acid in water. It is an aqueous germicidal composition having a combined amount of chlor of 0.01% by mass or more and 0.04% by mass or less (however, an aqueous germicidal composition for a dentifrice containing a combination of catechins, thymol and phytic acid). Except) .

Further, the present invention is formed by dissolving carvacrol and one or more kinds selected from fumaric acid and phytic acid in water in the aqueous disinfecting composition having the above-mentioned composition, and the blending amount of the carvacrol is 0.01. It is characterized in that the content is not less than mass% and not more than 0.04 mass %.

Further, the present invention is characterized in that, in the aqueous disinfecting composition having the above-mentioned constitution, the compounding amount of the fumaric acid and the phytic acid combined is 0.005 mass% or more and 1 mass% or less.

Further, the present invention, in the aqueous bactericidal composition of the above configuration, one or more selected from the thymol and carvacrol, one or more selected from the fumaric acid and phytic acid, and a solvent containing no ethanol, It is characterized by being composed of.

Further, the present invention, in the aqueous bactericidal composition of the above configuration, one or more selected from the thymol and carvacrol, one or more selected from the fumaric acid and phytic acid, and a solvent consisting of only water, It is characterized by being composed of.

According to the first configuration of the present invention, one or more selected from thymol and carvacrol is 0.01% by mass or more and 0.04% by mass, and one or more selected from fumaric acid and phytic acid, By suppressing the odor peculiar to thymol and carvacrol, it is possible to maintain a bactericidal effect by dissolving hydrazine in water, and an aqueous bactericidal composition having both high bactericidal power, safety and usability can be easily prepared. In addition, it can be manufactured at low cost.

Further, according to the second constitution of the present invention, in the aqueous disinfecting composition of the first constitution, carvacrol and one or more kinds selected from fumaric acid and phytic acid are dissolved in water, and By adjusting the content of chlor to 0.01% by mass or more and 0.04% by mass or less, a carbachlor having a weaker odor than that of thymol is used as a bactericidal component to provide an aqueous bactericidal composition having excellent usability. You can

Moreover, according to the 3rd structure of this invention, in the aqueous|water-based germicidal composition of the said 1st or 2nd structure, the compounding quantity which combined fumaric acid and phytic acid is 0.005 mass% or more and 1 mass% or less. By doing so, the blending amount of fumaric acid and phytic acid can be made a blending amount necessary and sufficient for improving the bactericidal effect of thymol and carvacrol.

According to a fourth aspect of the present invention, in the aqueous bactericidal composition of any of the first to third aspects, one or more selected from thymol and carvacrol and fumaric acid and phytic acid are used. A person who is not good at smelling ethanol or who has an allergy to ethanol, such as those who have a rough hand with ethanol, by using an aqueous germicidal composition composed of one or more selected solvents and a solvent that does not contain ethanol. The aqueous sterilizing composition can also be used, and stress cracking when applied to a resin member and peeling of wax or the like can be suppressed.

According to a fifth aspect of the present invention, in the aqueous bactericidal composition of any of the first to third aspects, one or more selected from thymol and carvacrol and fumaric acid and phytic acid are used. By using an aqueous bactericidal composition composed of one or more kinds selected and a solvent consisting of only water, a more safe aqueous bactericidal composition containing no organic solvent can be obtained.

Hereinafter, the aqueous germicidal composition of the present invention will be described in detail. The aqueous germicidal composition of the present invention comprises at least one selected from thymol and carvacrol as a germicidal component, and at least one selected from fumaric acid and phytic acid as a germicidal effect enhancer for thymol and carvacrol. It is an aqueous solution mixed with water.

Thymol is 2-isopropyl-5-methylphenol represented by the following chemical formula (1), and is a perfume ingredient having a relatively large solubility in water of 0.1 g/100 mL at 20°C.

Carvacrol is 2-methyl-5-isopropylphenol represented by the following chemical formula (2), and is a structural isomer of thymol having different positions of hydroxyl groups. Carvacrol has almost the same solubility in water as thymol, exhibits the same bactericidal activity as thymol, and has a weaker odor than that of thymol, and is therefore preferable as a bactericidal component to be added to the aqueous bactericidal composition of the present invention. Thymol and carvacrol may be blended individually, or may be blended in a mixture at a predetermined blending ratio.

If the blending amount of thymol and carvacrol in the aqueous disinfectant composition of the present invention is too large, the odor peculiar to thymol and carvacrol becomes strong and the usability deteriorates. Further, if the amounts of thymol and carvacrol are too small, a sufficient bactericidal effect cannot be obtained. Therefore, in order to maintain the sufficient bactericidal effect while suppressing the deterioration of the feeling of use due to the odor, it is necessary to set the compounding amount of thymol and carvacrol in the range of 0.01% by mass or more and 0.04% by mass or less. ..

Fumaric acid and phytic acid to be added to the aqueous germicidal composition of the present invention are used as a germicidal efficacy enhancer for improving the germicidal efficacy of thymol and carvacrol. Conventionally, it was known that certain organic acids enhance the bactericidal efficacy of perfume ingredients, but it was first discovered by the present inventors that fumaric acid and phytic acid significantly enhance the bactericidal efficacy of thymol and carvacrol. This is the knowledge obtained. Fumarate and phytic acid may be blended alone or in a mixture at a predetermined blending ratio.

The blending amount of fumaric acid and phytic acid in the aqueous germicidal composition of the present invention is not particularly limited, but if the blending amount is too small, the bactericidal effect of thymol and carvacrol may not be sufficiently enhanced. On the other hand, if the blending amount is too large, the bactericidal effect of thymol and carvacrol is not improved. The combined amount of fumaric acid and phytic acid is preferably in the range of 0.005% by mass or more and 1% by mass or less with respect to the entire aqueous disinfecting composition, and as shown in Examples described later, fumaric acid and phytinic acid. The combined amount of the acids is more preferably in the range of 0.01% by mass or more and 0.5% by mass or less with respect to the entire aqueous disinfecting composition.

A surfactant may be added to the aqueous germicidal composition of the present invention depending on the purpose. The surfactant has a property of generating foam (foaming property), and by using a surfactant having excellent foaming property, a liquid when the aqueous bactericidal composition of the present invention is sprayed on a wall surface by a trigger spray or the like. The sagging is suppressed and the coated area is easily visible.

The kind of the surfactant blended in the aqueous germicidal composition of the present invention is not particularly limited, and examples thereof include an anionic surfactant, a cationic surfactant, a nonionic surfactant and an amphoteric surfactant. The content of the surfactant in the aqueous fungicide of the present invention is not particularly limited, but is preferably 0.1% by weight or more and 10% by weight or less.

Examples of the anionic surfactant include sodium linear alkylbenzene sulfonate, alkali metal salt (soap) of fatty acid, sulfonate, and phosphate.

Examples of cationic surfactants include quaternary ammonium salts such as lauryl trimethyl ammonium chloride and benzalkonium chloride.

Examples of nonionic surfactants include polyoxyethylene alkyl ethers such as polyoxyethylene lauryl ether and long chain alkyl amine oxides such as lauryl dimethyl amine oxide.

Examples of amphoteric surfactants include betaine-type surfactants. Specific examples thereof include lauryl-N,N-dimethyl acetic acid betaine, lauryl amidopropyl-N,N-dimethyl acetic acid betaine, and palm alkylamidopropyl-N,N-dimethylhydroxypropyl sulfobetaine.

The liquid sterilizing composition of the present invention is an aqueous type, and water is mainly used as a solvent. Examples of water include purified water such as ion exchanged water and reverse osmosis water, ordinary tap water, industrial water, and deep sea water. If necessary, solvents other than ethanol, such as various glycols and glycol ethers, which have a low risk of ignition, can be used. Since the flash point of ethanol is about 13°C in the closed state, it is preferable to use a solvent having a flash point of 20°C or higher in the closed state.

Furthermore, in the liquid sterilizing composition of the present invention, as other components, if necessary, inorganic antibacterial agents, organic antibacterial agents, algae inhibitors, rust preventives, chelating agents, fragrances, deodorant ingredients, etc. By blending in a range that does not impair the effects of the invention, an antibacterial effect, an algae preventing effect, a rust preventing effect, a cleaning effect, an aromatic property, a deodorizing property and the like may be imparted.

The aqueous bactericidal composition of the present invention thus obtained, kitchen or bathroom drainage, tile joints, etc., by applying or spraying on the places where bacteria and mold are likely to occur, sterilizing bacteria and mold, and thereafter It can prevent the occurrence. The aqueous germicidal composition of the present invention is extremely practical because it does not contain ethanol and thus can be applied safely and easily without danger of ignition. In addition, since it does not contain ethanol, it can be used by people who do not like the smell of ethanol, people who have rough hands with ethanol, and people with allergies, and it is possible to suppress the peeling of wax and wax when it is applied to resin members. ..

In addition, the aqueous germicidal composition of the present invention contains one or more species selected from thymol and carvacrol as germicidal components and one or more species selected from fumaric acid and phytic acid as germicidal efficacy enhancers in water. It's just a very simple composition. And, thymol, carvacrol, fumaric acid, and phytic acid are all highly safe compounds used as food additives. Therefore, the production is simple, the irritation to the skin, which is a problem with many fungicides, is small, and the safety is extremely high.

It should be noted that the present invention is not limited to the above-described embodiments, and various modifications can be made within the scope shown in the claims, and implementations obtained by appropriately combining the technical means disclosed in the different embodiments. The form is also included in the technical scope of the present invention. Hereinafter, the effects of the present invention will be described more specifically with reference to Examples, but the present invention is not limited to these Examples.

[Preparation of test solution]
(A) One or more selected from thymol (manufactured by Wako Pure Chemical Industries, Ltd.) and carvacrol (manufactured by Wako Pure Chemical Industries, Ltd.) as a bactericidal component, and (B) a fumaric acid (Wako Pure Chemical Industries, Ltd.) (Manufactured by Kogyo Co., Ltd.) and phytic acid (manufactured by Wako Pure Chemical Industries, Ltd.) at the compounding ratio (mass %) shown in Table 1, and purified water was added to 100% by weight to obtain a test liquid (Inventions 1 to 11). It was

(A) One or more kinds selected from thymol and carvacrol as a bactericidal component, and (B) a bactericidal efficacy enhancer containing citric acid, acetic acid, lactic acid, phosphoric acid, fumaric acid and phytic acid as a blending ratio shown in Table 2. (% by mass), and purified water was added to 100% by weight to obtain test solutions (Comparative Examples 1 to 13). Also, thymol and carvacrol, citric acid, acetic acid, lactic acid, phosphoric acid, fumaric acid, and phytic acid were mixed at the mixing ratios (mass %) shown in Table 3, and purified water was added to 100% by weight to prepare a test solution ( Comparative Examples 14-21) were obtained.

[Confirmation test of sterilization effect (Staphylococcus aureus)]
990 μL of the test liquid of the present invention and Comparative Example was inoculated with 10 μL of a culture solution of S. aureus and well stirred, and then the mixture was diluted 100-fold with SCDLP medium. The time from inoculation to dilution was 5 minutes. 100 μL of this diluted solution was dropped on SCDLP agar medium which had been solidified in a sterilized plastic petri dish, and well spread with a conradi stick, followed by culturing at 37° C. and counting the number of generated colonies. Also, as a control example (negative control), a test solution using sterilized water instead of the test solution was prepared. The eradication rate was calculated by comparing the number of colonies of the test sample and that of the control.

As an evaluation standard, when the sterilization rate was 99% or more, it was evaluated as ◯, when the sterilization rate was 90% to 99% as Δ, and when the sterilization rate was less than 90% (equivalent to the control example). .. The test results of the sterilization effect are shown in Tables 1 to 3 together with the formulation of the test solution.

As shown in Table 1, the present invention 1 to 5, 0.01 to 0, in which 0.01 to 0.035% by mass of thymol and 0.01 to 0.5% by mass of fumaric acid or phytic acid are blended. Inventions 6 to 9 in which 0.035% by mass of carvacrol and 0.011 to 0.5% by mass of fumaric acid or phytic acid are blended, and 0.015% by mass of thymol and 0.015% by mass of carba In the present inventions 10 and 11 in which chlor and 0.05% by mass of fumaric acid or phytic acid were blended, the sterilization rate was 99% or more for S. aureus, and the sterilization rate was 99% or more. The treatment for 5 minutes completely killed Staphylococcus aureus.

On the other hand, as shown in Table 2, Comparative Examples 1 to 3 and 5 in which 0.03% by mass of thymol or carvacrol and 0.05 to 0.5% by mass of citric acid, acetic acid or lactic acid were blended. In No. 7, the sterilization rate was less than 90%, which was equivalent to the control example. Further, in Comparative Examples 4 and 8 in which thymol or carvacrol of 0.03 mass% and phosphoric acid of 0.1 mass% were mixed, the sterilization rate was 90% to 99%, and the sterilization effect was not sufficient. .. Furthermore, in Comparative Examples 9 to 13 in which 0.0035 to 0.005 mass% of thymol or carvacrol was mixed with fumaric acid or phytic acid, the sterilization rate was less than 90%, and the sterilization effect was not sufficient.

Comparative Examples 1 to 8 in which thymol or carvacrol and citric acid, acetic acid, lactic acid, or phosphoric acid were blended were obtained by comparing Inventions 1 to 5 and Comparative Examples 1 to 4 and Inventions 6 to 9 and Comparative Examples 5 to 8. However, a sufficient bactericidal effect with immediate effect was not observed, but it is confirmed that the present invention 1 to 9 in which thymol or carvacrol and fumaric acid or phytic acid are mixed provides a rapid bactericidal effect. Was done. Further, from the results of Comparative Examples 9 to 13, when the combined amount of thymol and carvacrol was less than 0.01% by mass, sufficient bactericidal effect was not observed.

On the other hand, as shown in Table 3, in Comparative Examples 14 and 15 in which thymol and carvacrol were blended alone, and in Comparative Examples 16 to 21 in which citric acid, acetic acid, lactic acid, fumaric acid phosphate or phytic acid were blended alone, In all cases, the eradication rate was less than 90%, and no eradication effect was observed.

From the above results, fumaric acid and phytic acid have no bactericidal effect on the compound itself, but when combined with thymol or carvacrol, they act specifically as bactericidal efficacy enhancers of thymol and carvacrol. It was confirmed. It was also confirmed that organic acids other than fumaric acid and phytic acid did not have a bactericidal effect on the compound itself, and did not sufficiently act as a bactericidal effect enhancer even when added together with thymol or carvacrol.

The present invention is an aqueous bactericidal composition having sufficient bactericidal efficacy, safety, and usability while suppressing the odor by suppressing the blending amount of thymol and carvacrol, which are bactericidal components, in water, and particularly in kitchens and bathrooms. It is preferably used as a bactericide used in the above.

Claims (5)

It is made by dissolving at least one selected from thymol and carvacrol and at least one selected from fumaric acid and phytic acid in water, and the compounding amount of the above thymol and carvacrol is 0.01 mass. % Or more and 0.04 mass% or less (excluding an aqueous bactericidal composition for dentifrice containing a combination of catechins, thymol and phytic acid) . It is formed by dissolving carvacrol and at least one selected from fumaric acid and phytic acid in water, and the blending amount of the carvacrol is 0.01% by mass or more and 0.04% by mass or less. The aqueous disinfecting composition according to claim 1. The amount of the fumaric acid and phytic acid combined is 0.005% by mass or more and 1% by mass or less, and the aqueous disinfectant composition according to claim 1 or 2. The composition comprises at least one selected from thymol and carvacrol, at least one selected from fumaric acid and phytic acid, and a solvent containing no ethanol. Item 4. The aqueous germicidal composition according to any one of Items 3. The composition comprising at least one selected from thymol and carvacrol, at least one selected from fumaric acid and phytic acid, and a solvent consisting only of water. Item 4. The aqueous germicidal composition according to any one of Items 3.