JP6738388B2 - Urinary frequency improving agent - Google Patents

Description

TECHNICAL FIELD The present invention relates to a female frequent urine improving agent containing cranberry juice, a female sleep improving agent containing cranberry juice, or a female skin condition improving agent containing cranberry juice.

Regarding the efficacy of cranberries in humans, it has been suggested to be effective only against urinary tract infections (Non-patent Document 1).

On the other hand, development of functional foods and drinks that utilize the inherent functions of natural products has been awaited as supplements without side effects.

National Institute of Health and Nutrition, "Health Food" Material Information Database, Cranberry, http://hfnet.nih.go.jp/contents/detail503lite.html, Overview section

The present invention provides a novel female frequent urinary frequency improving agent, female sleep improving agent, or female skin condition improving agent.

As a result of diligent research, the present inventor has surprisingly found that cranberry juice has a novel effect of improving frequent urination of women, an effect of improving sleep of women, and an effect of improving skin condition of women. Was completed. That is, the present invention is as follows.
[1] An agent for improving female frequent urination, which comprises cranberry juice,
[2] The frequent urination improver for women according to [1], wherein the frequency of urination is the total number of times of urination and the urgency of urine in 24 hours,
[3] The agent for improving female frequent urination according to [1] or [2], wherein the cranberry is Vaccinium macrocarpon.
[4] A sleep improving agent for women containing cranberry juice,
[5] The sleep-improving agent for women according to [4], wherein the cranberry is Vaccinium macrocarpon.
[6] A skin condition improving agent for women, which comprises cranberry juice,
[7] The improving agent for the female skin condition according to [6], wherein the skin condition is moisturizing the skin, texture of the skin, firmness of the skin and transparency of the skin.
[8] The agent for improving female skin condition according to [6] or [7], wherein the cranberry is Vaccinium macrocarpon.

INDUSTRIAL APPLICABILITY The present invention has an effect of improving frequent urination in women, an effect of improving sleep in women, and an effect of improving skin conditions in women.

Cranberry is a general term for evergreen shrubs belonging to the subgenus Cervberry genus of the azalea family Vaccinium. Preferable are Vaccinium oxycoccos, Vaccinium microcarpum, Vaccinium macrocarpon, Vaccinium macrocarpon, and Vaccinium erythrocarp. More preferably, it is a Vaccinium macrocarpon.

The cranberry fruit component is used in the present invention. Specifically, a fruit squeezed liquid (fruit juice), a fruit extract, a fruit juice or extract concentrate, or a dried product can be used. A polar solvent such as water, alcohol (for example, ethyl alcohol), glycol, or glycerin can be used for extracting the fruit.

INDUSTRIAL APPLICABILITY The present invention is useful for improving frequent urination in women, improving sleep in women, or improving skin condition in women.

Sleep improvement refers to alleviation of temporary insomnia symptoms such as "poor sleepiness" and "light sleep." Temporary insomnia refers to "transient insomnia experienced by a person who has no pathological cause such as mental illness".

The female frequent urinary urine improving agent, the female sleep improving agent, or the female skin condition improving agent of the present invention can be contained in a food or a dietary supplement. Examples of foods include grains, vegetables, meat, various processed foods, confectionery/desserts, milk, soft drinks, fruit juice drinks, coffee drinks, and vegetable juice drinks. In addition, examples of the dietary supplement include supplements and nutritional drinks. In the case of a dietary supplement, it can be provided in the form of a liquid such as powder, powdered granules, tablets, pastes and juices. By providing in the form of juice, it becomes easy to take the active ingredient of the present invention on a daily basis or continuously.

Sixteen women (age 47.9±13.05 years old) who have a tendency to have frequent urination more than 20 years old but less than 80 years old were ingested 100 ml of cranberry juice (Marukai pre-selected cranberry 100) once a day for 12 weeks. I examined the item.

1. Frequent urination Using the Overactive Bladder Symptoms Questionnaire (OABSS), the number of urinary urination during the daytime (daytime), the number of urination at night, urgency and urinary incontinence were investigated. The total score was 5 or less for all the subjects, which was judged to be mild. The reference value before ingestion was 3.2±0.26, while the value after 12 weeks was 1.8±0.28, showing a significant decrease (p<0. 01, by Wilcoxon signed rank test with before ingestion. The same shall apply hereinafter.). More specifically, there was a significant decrease in the number of urinary urination and urge incontinence, but no significant decrease in the number of urinary urination and urgency.
The total number of urinations over 24 hours using the voiding diary was significantly reduced from 10.3±0.64 before ingestion to 8.4±0.65 after 12 weeks (p<0.05). .. On the other hand, the 24-hour urine volume (ml) was not significantly different between 1,477.8±86.22 before ingestion and 1,575.0±173.52 after 12 weeks. That is, the intake of cranberry juice did not decrease the urine volume, but the urination frequency was significantly decreased. The number of urgency feelings also decreased significantly from 2.8±0.79 before ingestion to 1.0±0.32 after 12 weeks (p<0.05).
No significant changes were observed in the number of nocturnal voids and the amount of nocturnal urine.

2. Sleep Improvement Using the Pittsburgh Sleep Questionnaire Japanese version, seven points of sleep quality, sleep onset time, sleep time, sleep efficiency, sleep difficulty, use of sleeping pills, and daytime awakening difficulty were investigated. The overall score was 6.0±0.75 before ingestion, whereas the value after 12 weeks was 4.0±0.79, showing a significant decrease ( p<0.01). More specifically, there was a significant decrease in sleep time, difficulty sleeping, and difficulty waking up during the day, but no significant decrease was observed in sleep quality, sleep onset time, sleep efficiency, and use of hypnotics. It was

3. Skin condition Moisture of the skin, texture of the skin, softness of the skin, smoothness of the skin, rough skin, texture of the skin, makeup paste, firmness of the skin, wrinkles on the skin, translucency of the skin, skin color, a smooth feeling after washing the face, We investigated the stickiness of the skin. As a result, a significant increase (improvement) was observed in the moisture of the skin and the texture of the skin (p<0.05), the firmness of the skin and the transparency of the skin (p<0.01).

No particular adverse events were observed throughout the study. No significant changes were observed in weight, blood pressure, urine test, or hematological test.

INDUSTRIAL APPLICABILITY The present invention is useful for improving frequent urination in women, improving sleep in women, or improving skin condition in women.

Claims (2)

An agent for improving sleep time, sleep difficulty, or daytime awakening difficulty in women, which comprises only cranberry juice as an active ingredient. The agent for improving sleep time, sleep difficulty or daytime awakening difficulty of a woman according to claim 1, wherein the cranberry is Vaccinium macrocarpon.