JP6795889B2 - Wet wipe roll - Google Patents

Description

The present invention relates to a roll of wet tissue which is excellent in bactericidal effect and antifungal effect and has reduced irritation to the skin.

Wet wipes are generally used for removing stains and germs on fingers and cleaning various instruments, and tend to be handled with bare hands. Conventionally, paraoxybenzoic acid ester (hereinafter, also referred to as paraben), ethanol, propylene glycol and the like have been blended in these wet tissues (see, for example, Patent Document 1), but these components are irritating to the skin. It is known that some users may have an allergic reaction to these ingredients, and by applying a drug solution containing these ingredients to their fingers, An unfavorable sticky or slimy feeling may be felt (see, for example, Patent Documents 2 and 3). Therefore, in order to reduce irritation to the skin and enable users who are sensitive to skin irritation such as infants to use it with peace of mind, we have provided wet wipes that do not use parabens, ethanol, propylene glycol, etc. Was required to do.

Here, the chemical solution to be impregnated with the wet tissue is characterized in that 99.0% by mass or more of the chemical solution component is water by reducing the content of paraben, ethanol, propylene glycol and other bactericides and preservatives. Wet wipes are known.

For example, in Patent Document 4, in a wet tissue in which a chemical solution containing no paraben is contained in a sheet base material having water retention, a predetermined amount of polyaminopropyl biguanide, gluconolactone, and benzoic acid are contained in the chemical solution. Wet wipes are disclosed that are characterized by containing sodium acid, calcium gluconate, and water. Patent Document 5 describes a wet tissue in which a non-woven fabric sheet is impregnated with a chemical solution, wherein the chemical solution contains 99.80% by mass or more and less than 99.95% by mass of water, and a predetermined amount of benzalkonium chloride and butylcarbamic acid. A wet tissue characterized by blending propynyl iodide and glycols is disclosed. Patent Document 6 describes a wet tissue in which a non-woven fabric having water retention and a chemical solution containing no paraben is contained, and a predetermined amount of polyaminopropyl biguanide, gluconolactone, sodium benzoate, and glucon are contained in the chemical solution. Wet wipes containing calcium gluconate and water are disclosed.

In order for a wet tissue impregnated with a chemical solution to exert a sufficient bactericidal effect, it is necessary to add a certain amount or more of a bactericidal agent or a preservative to the chemical solution. Therefore, the bactericidal agent and the preservative in the chemical solution for wet tissue The blending ratio is appropriately set by those skilled in the art from the viewpoints of both preventing rough skin and exerting bactericidal and antiseptic effects.

By the way, as the wet tissue, a laminated type wet tissue and a roll type wet tissue are generally known.

The laminated sheet type wet tissue is manufactured by impregnating each wet tissue with a chemical solution and then laminating them. Then, chemicals such as bactericides and preservatives are blended in this chemical solution, and by uniformly containing each chemical in each wet tissue, each wet tissue has uniform quality, antifungal property, antibacterial property, and storage. It is possible to impart sex and the like. However, if the sheets are folded and laminated and the number of sheets is increased from 80 to 90 or more, additional capital investment is required such as the introduction of a laminating device to realize this, or 80 or less sheets. There is a problem that it may be necessary to manually stack two or more piles of sheets laminated in the same number of sheets, and there is a problem that the cost for that is increased. In addition, additional equipment and manpower may be required to prevent the bulky laminated sheets from tipping over, or alternatives may be required to reduce bulkiness. There was also.

As such an alternative means, for example, each sheet is usually folded a plurality of times and then laminated, but it is conceivable to reduce the number of times of folding and reduce the bulkiness of each sheet. .. However, even in such a case, if the area of the sheet before folding is the same, there is a problem that the bottom area of the laminated sheet becomes wider by reducing the number of times of folding. As another alternative means, a means for suppressing the bulkiness when laminated by reducing the basis weight of the non-woven fabric can be considered, but when such a means is adopted, each sheet is made thicker. There is also the problem that it is difficult.

In the case of roll-type wet wipes, even if the number of wet wipes is increased to 100 or 150, there is no problem of increasing equipment costs during manufacturing, and the manufacturing cost is suppressed compared to wet wipes in the form of laminated sheets. You can also do it. In addition, by putting it in a substantially cylindrical plastic container with a take-out port that can be easily taken out, the substantially cylindrical portion can be the bottom surface, the installation area does not increase, and the substantially cylindrical plastic container is expensive. Because of this, it has the advantage of being conspicuous and easy to find in places such as stores and homes. Since the roll-type wet tissue has perforations, it can be torn off one by one at the container outlet, and no tool for cutting with scissors or the like is required.

Japanese Unexamined Patent Publication No. 02-061000 Japanese Unexamined Patent Publication No. 2002-003306 Japanese Unexamined Patent Publication No. 2003-079530 Japanese Unexamined Patent Publication No. 2008-295837 Japanese Unexamined Patent Publication No. 2012-024520 Japanese Unexamined Patent Publication No. 2008-1194333

Here, the wet tissue that does not substantially contain paraben, ethanol, or propylene glycol as described in Patent Document 4 is a laminated sheet type wet tissue, and perforations are made at regular intervals perpendicular to the winding direction. In the roll-type wet wipes having, those characterized in that 99.0% by mass or more of the chemical solution component is water and do not contain paraben, ethanol, or propylene glycol have not been provided conventionally. Further, in the invention of Patent Document 4, the amount of the chemical solution impregnated in the non-woven fabric tends to be large, and the mode of impregnating the non-woven fabric with a smaller amount of the chemical solution is not necessarily assumed.

In the case of roll-type wet wipes, when impregnating the roll of the non-woven fabric with the chemical solution, the method of applying the chemical solution from the upper part of the roll of the non-woven fabric to the upper surface of the substantially cylindrical surface, and the side surface portion of the roll of the non-woven fabric and the central portion of the upper surface of the substantially columnar surface. Although there is a method of impregnating with the chemical solution from two places, in order to prevent the wet tissue from being torn due to the perforations provided in the manufacturing process, each wet tissue is impregnated with the chemical solution and then wound up. It is not possible. Therefore, it has been pointed out that the distribution of chemicals and the distribution of fungicides and preservatives are uneven. Such a problem is particularly remarkable in a roll-type wet tissue having a large number of winding sheets, and for example, in a roll-type wet tissue having about 40 winding sheets such as the wet tissue described in Patent Document 1. Was not a problem that became apparent. Furthermore, when polyaminopropyl biguanide, which is used as a disinfectant in the inventions described in some prior art documents, is used for roll-type wet wipes, the polyaminopropyl biguanide tends to be adsorbed on the non-woven fabric. It has also been pointed out that there is a problem that the disinfectant does not penetrate into the interior.

In order to fully exert the bactericidal and antiseptic effect and obtain a wet tissue with good storage stability, it is necessary to increase the amount of the chemical solution in order to spread the chemical solution, the bactericidal agent, and the preservative throughout the roll. When used for removing stains or cleaning various devices, there is a problem that the amount of the chemical solution is partially too large.

If the amount of liquid cannot be increased, it is necessary to add paraben, ethanol, or propylene glycol to prevent the growth of bacteria and mold, or to increase the amount of other fungicides and preservatives. However, in such a case, there is a problem that a user who is particularly sensitive to skin irritation feels irritation and the raw material cost is high.

Therefore, the present invention has been made in view of the above problems, and is a roll of wet tissue, which does not contain paraben, ethanol, or propylene glycol in the chemical solution, and the amount of water in the chemical solution is 99. An object of the present invention is to provide a roll of wet tissue capable of preventing the growth of bacteria and mold even if the content is 0% by mass or more.

In view of the above problems, the inventors of the present invention have conducted diligent research. As a result, it is a roll of wet tissue in which a non-woven fabric is impregnated with a chemical solution, and the chemical solution is sodium benzoate, benzalkonium chloride, cetylpyridinium chloride, propynyl iodide butylcarbamate, and disodium ethylenediaminetetraacetate. We have found that a roll of wet tissue containing a predetermined amount of hydrate can solve the above problems, and have completed the present invention. Specifically, the present invention provides the following.

(1) The first aspect of the present invention is a roll of wet tissue in which a non-woven fabric is impregnated with a chemical solution, wherein the chemical solution is 1.0 × 10 ^-1 % by mass or more and 5.0 × 10 ^-1 mass. % Or less sodium benzoate, 1.5 × ^10-2 % by mass or more 5.0 × 10 ^-2 % by mass or less benzalconium chloride, 5.0 × 10 ^-3 % by mass or more 1.0 × 10 ^-1 mass% of cetylpyridinium chloride, 5.0 × ^{10 -4%} by weight or more 6.0 × ^{10 -3} mass% of iodopropynyl butylcarbamate, 4.0 × ^{10 -2} wt% or more 2.0 × containing 10 ^-1 mass% of disodium ethylenediaminetetraacetate dihydrate, a roll of the wet tissues.

(2) The second aspect of the present invention is the roll body of the wet tissue according to (1), wherein the chemical solution impregnated in 100 parts by mass of the nonwoven fabric is 180 parts by mass or more and 350 parts by mass or less. It is characterized by being.

(3) A third aspect of the present invention is the roll body of the wet tissue according to (1) or (2), wherein the nonwoven fabric has perforations at regular intervals perpendicular to the winding direction thereof. The width of the sheet of the non-woven fabric is 90 mm or more and 200 mm or less, the basis weight of the non-woven fabric is 20 g / m ² or more and 50 g / m ² or less, and the non-woven fabric is wound with the basis weight (g / m ² ). It is characterized in that the product of the taking length (m) is 400 g / m or more and 1,000 g / m or less.

(4) A fourth aspect of the present invention is the roll body of the wet tissue according to any one of (1) to (3), wherein the chemical solution is 2.0 × 10 ^-1 % by mass or more. 0 × 10 ^-1 % by mass or less of sodium benzoate, 2.0 × 10 ^-2 % by mass or more and 5.0 × 10 ^-2 % by mass or less of benzalconium chloride, 8.0 × 10 ^-3 % by mass or more 5 .0 × 10 ^-2 % by mass or less of cetylpyridinium chloride, 9.6 × 10 ^-4 % by mass or more and 3.0 × 10 ^-3 % by mass or less of propynyl iodide butylcarbamate 4.0 × 10 ^-2 % by mass It contains% or more and 1.0 × 10 ^-1 % by mass or less of ethylenediamine disodium tetraacetate / dihydrate, and 99.0% by mass or more of water.

(5) A fifth aspect of the present invention is the roll of wet tissue according to (4), wherein the content of the paraoxybenzoic acid ester in the chemical solution is 1 ppm or less, and the content of propylene glycol is 1 ppm. It is characterized in that the content of ethanol is 1 ppm or less.

(6) A sixth aspect of the present invention is the roll of wet tissue according to (5), wherein the drug solution does not contain paraoxybenzoic acid ester, propylene glycol, and ethanol. It is a thing.

(7) A seventh aspect of the present invention is the roll body of the wet tissue according to any one of (1) to (6), wherein the chemical solution is further 1.0 × 10 ^-3 % by mass or more. It is characterized by containing 1.0 × 10 ^-1 % by mass or less of a plant extract.

(8) An eighth aspect of the present invention is the roll of wet tissue according to (7), wherein the plant extract is an artea root extract, ononis extract, chamomile flower extract, sugina extract, and sardine flower extract. , Sage leaf extract, celery extract, Tachijakousou flower / leaf / stem extract, Fukitanpopo extract, Melissa leaf extract, Arnica flower extract, Otogirisou flower / leaf / stem extract, Seiyoukizuta leaf / stem extract, Seiyounokogirisou extract, Tokinsenka flower It is characterized in that it is at least one selected from the group consisting of an extract and a grapefruit seed extract.

(9) A ninth aspect of the present invention is the roll of wet tissue according to any one of (1) to (8), which has a sterilization activity value of 2.0 or more in Escherichia coli and Staphylococcus aureus. It is characterized in that it is 2.0 or more.

In the wet tissue roll of the present invention, the chemical solution impregnated therein contains sodium benzoate, benzalkonium chloride, cetylpyridinium chloride, propynyl iodide butylcarbamate, and disodium ethylenediaminetetraacetate / dihydrate5. A combination of different types of ingredients is used, and the amount used is a predetermined amount. By specifically using the combination of these five types of components, even if it is a roll type wet tissue, the entire wet tissue can be used without increasing the amount of the chemical solution or the compounding of chemicals such as bactericides and preservatives. The drug penetrates into the wipe, and the entire wet tissue becomes antibacterial and antiseptic.

Further, since the roll body of the wet tissue of the present invention does not contain paraben, ethanol, or propylene glycol in the chemical solution, it has low skin irritation, and even a user who is sensitive to skin irritation such as an infant can feel at ease. Can be used.

Hereinafter, embodiments for carrying out the present invention will be described in detail.

<Roll body of wet tissue>
The roll body of the wet tissue of the present invention is a roll body of a non-woven fabric impregnated with a predetermined chemical solution.

[Non-woven fabric]
As the non-woven fabric, wood pulp fibers, recycled fibers such as rayon, natural fibers such as cotton, and synthetic fibers such as polyethylene, polypropylene, and polyethylene terephthalate are used in the chemical bond method, spunlace method, spunbond method, needle punch method, and airlaid method. , Wet spun lace method, spun bond method, melt bond method and other known processing methods can be used. The ratio of each fiber used for the non-woven fabric and each processing method for integrating the non-woven fabric may be appropriately selected according to the texture and mechanical strength required for the wet tissue.

In producing a roll of wet tissue, it is preferable to perforate the above-mentioned non-woven fabric at regular intervals perpendicular to the winding direction and wind the non-woven fabric into a roll shape. The width of the non-woven fabric sheet is preferably 90 mm or more and 200 mm or less, and the winding length of the non-woven fabric is preferably 8 m or more and 50 m or less. The basis weight of the non-woven fabric is 20 g / m ² or more and 50 g / m ² or less, and the product of the basis weight (g / m ² ) of the non-woven fabric and the winding length (m) is 400 g / m or more and 1,000 g / m. It is preferably 500 g / m or more, and more preferably 800 g / m or less. By setting the basis weight of the non-woven fabric and the product of the basis weight and the winding length within the above range, the wet tissue has an appropriate texture and strength. In addition, the production cost of the roll of wet tissue can be suppressed, and even when the chemical solution is impregnated from the outside, the chemical solution and the bactericidal / preservative can be impregnated even inside.

[Chemical solution]
In the production of wet tissue rolls, the chemicals to be impregnated in the non-woven fabric are sodium benzoate, benzalkonium chloride, cetylpyridinium chloride, propynyl iodide butylcarbamate, and disodium ethylenediaminetetraacetate / dihydrate. Mix. Only by using these five types of agents in combination, the agents can sufficiently penetrate into the roll even in roll-type wet wipes, and the entire roll of the wet wipes exhibits antibacterial and antifungal properties. It becomes possible to provide a wet tissue using a chemical solution of 99.0% by mass or more of water without using a highly irritating component such as paraben, ethanol, or propylene glycol. The chemical solution used for producing the wet tissue preferably has a paraben content of 1 ppm or less, an ethanol content of 1 ppm or less, and a propylene glycol content of 1 ppm or less, and these components are not blended. More preferred.

In particular, when applied to a roll of non-woven fabric, some components known as fungicides may be adsorbed on the surface of the roll and not penetrate into the inside. In the chemical solution used for the roll body of the wet tissue of the present invention, by using the above five kinds of components in combination, each component penetrates into the roll body of the non-woven fabric and has sufficient antibacterial and antifungal properties. Will be able to demonstrate.

The non-woven fabric is preferably impregnated with a chemical solution of 180 parts by mass or more and 350 parts by mass or less per 100 parts by mass of the non-woven fabric, and more preferably 200 parts by mass or more and 280 parts by mass or less. By keeping the amount of chemical solution within the above range, when removing stains on fingers and various devices, the amount of chemical solution does not become too large, and the non-woven fabric exerts a sufficient bactericidal and antiseptic effect. At the same time, dirt and germs can be sufficiently removed with a small number of wipes.

(Sodium benzoate)
Sodium benzoate is a drug that has an effect as a bactericidal preservative. The content of sodium benzoate in the drug solution is 1.0 × 10 ^-1 % by mass or more and 5.0 × 10 ^-1 % by mass or less, and 2.0 × 10 ^-1 % by mass or more and 4.0 × 10 ^-1. It is preferably mass% or less. By setting the content of sodium benzoate within the above range, it is possible to maintain good bactericidal effect and antifungal effect while keeping the production cost within an appropriate range.

(Benzalkonium chloride)
Benzalkonium chloride is a drug that has an effect mainly as a fungicide against bacteria. The content of benzalkonium chloride in the chemical solution is 1.5 × 10 ⁻² mass% or more and 5.0 × 10 − ² mass% or less, and 2.0 × 10 − ² mass% or more and 5.0 × 10 ^−. It is preferably ² % by mass or less. By keeping the content of benzalkonium chloride within the above range, the manufacturing cost can be kept within an appropriate range, and the bactericidal effect and antifungal effect can be achieved without causing a feeling of use such as stickiness and sliminess. Can be maintained well.

(Cetylpyridinium chloride)
Cetylpyridinium chloride is a drug that mainly acts as a bactericidal agent against bacteria. The content of cetylpyridinium chloride in the chemical solution is 5.0 × 10 ^-3 % by mass or more and 1.0 × 10 ^-1 % by mass or less, and 8.0 × 10 ^-3 % by mass or more and 5.0 × 10 ^-2. It is preferably mass% or less. When the content of cetylpyridinium chloride is within the above range, the bactericidal effect and the antifungal effect can be well maintained while keeping the production cost within an appropriate range.

(Propinyl iodide butylcarbamate)
Propinyl iodide butylcarbamate is a drug that mainly acts as a preservative against fungi. The content of propynyl butylcarbamate iodide in the chemical solution is 5.0 × 10 ^-4 % by mass or more and 6.0 × 10 ^-3 % by mass or less, and 9.6 × 10 ^-4 % by mass or more and 3.0 × It is preferably ^10-3 % by mass or less. When the content of propynyl iodide butylcarbamate is within the above range, the production cost is suppressed to an appropriate range, the expression of odor peculiar to propynyl iodide butylcarbamate is also suppressed, and the bactericidal effect is suppressed. And the antifungal effect can be maintained well.

(Ethylenediaminetetraacetic acid disodium dihydrate)
Ethylenediaminetetraacetic acid disodium dihydrate is a chelating agent, which is effective as a bactericidal preservative. The content of ethylenediaminetetraacetic acid disodium / dihydrate in the chemical solution is 4.0 × 10 ^-2 % by mass or more and 2.0 × 10 ^-1 % by mass or less, and 4.0 × 10 ^-2 % by mass or more. It is preferably 1.0 × 10 ^-1 % by mass or less. When the content of disodium ethylenediaminetetraacetate / dihydrate is within the above range, the bactericidal effect and the antifungal effect can be well maintained while keeping the production cost within an appropriate range.

In the present invention, by using these five kinds of components in combination, a sufficient bactericidal effect and antifungal effect can be obtained without using components having strong skin irritation such as paraben, ethanol and propylene glycol. Wet wipes can be provided.

(Other ingredients)
The chemical solution used for the roll of the wet tissue of the present invention may contain a plant extract in addition to the above-mentioned five kinds of components. By containing the plant extract, it is possible to impart plant-derived antibacterial activity, SOD-like activity, anti-inflammatory action, astringent action, estrogen-like action, hyaluronic acid production promoting action, etc. to the roll body of the wet tissue. At the same time, an appropriate aroma can be imparted. The content of the plant extract in the chemical solution is preferably 1.0 × 10 ^-3 % by mass or more and 1.0 × 10 ^-1 % by mass or less.

The plant extract that can be used in producing a roll of wet tissue is not particularly limited as long as it can impart antibacterial properties to the wet tissue, but specifically, an artea root extract. , Ononis extract, chamomile flower extract, sugina extract, sage leaf extract, celery extract, tachijakousou flower / leaf / stem extract, fukitanpopo extract, melissa leaf extract, arnica flower extract, otogirisou flower / leaf / stem extract, At least one selected from the group consisting of stalk leaf / stem extract, sardine extract, tokinsenka flower extract, and grapefruit seed extract can be mentioned. Among these, it is more preferable to use grapefruit seed extract.

[Bactericidal activity]
The roll of the wet tissue of the present invention preferably has a sterilization activity value of 2.0 or more for Escherichia coli and 2.0 or more for Staphylococcus aureus.

The sterilization activity value is measured and calculated according to the "Test method for sterilization performance of wet wipers" (revised on November 16, 2015) edited by the Japan Sanitary Materials Industry Association. Bacteria are inoculated on the plate with appropriate stains, dried, wiped off with a weight wrapped with a wet tissue a predetermined number of times, and allowed to stand for 5 minutes to inactivate the disinfectant active substance on the stainless steel plate. It is performed by measuring the viable cell count, and the sterilization activity value R is specifically calculated by the following formula.
R = AB
A: Mean of common logarithm of viable cell count as a result of three trials with a control sample B; Mean of common logarithm of viable cell count as a result of three trials with a test sample

<Manufacturing method of roll of wet tissue>
The roll body of the wet tissue of the present invention can be produced, for example, by the production method shown below. The raw fabric of the non-woven fabric is wound by a winder to unwind the band of the non-woven fabric, and the non-woven fabric is wound on a stainless steel core having a diameter of 20 mm to 40 mm while being perforated at regular intervals perpendicular to the winding direction. Here, the unwoven fabric having a width that is an integral multiple of the width of the non-woven fabric of the product may be set in the winder and cut into a predetermined width with a slitter. When the wound roll is removed from the stainless steel core and then conveyed by a conveyor to prepare a bottle container type, the drug solution is poured into the container and then divided into several times from the upper surface side of the cylinder. Call. After impregnating with the chemical solution, the top surface of the container may be sealed and the cap may be attached to the container.

When preparing a roll of wet tissue as a refillable type product, the wound roll is removed from the stainless steel core and then transferred to a bucket by a machine, and the side surface portion and the upper surface portion of the cylinder are substantially formed. Sprinkle the chemical solution on the two central parts. After impregnation with the liquid, the wound product may be wrapped with a multilayer film using a packaging machine.

<Example 1>
2.5 × 10 ^-1 part by mass of sodium benzoate, 2.5 × 10 ^-2 part by mass of benzalkonium chloride, 1.0 × 10 ^-2 part by mass of cetylpyridinium chloride with respect to 99.66 parts by mass of purified water. , ^10-3 parts by weight of iodide butyl carbamate of propynyl 1.2 ×, the addition of disodium ethylenediaminetetraacetate dihydrate 5.0 × ^{10 -2} parts by weight, and the total amount 100 mass parts. This chemical solution was impregnated into a roll of a non-woven fabric having a winding length of 30 m and a basis weight of 24 g / m ² to obtain a wet tissue roll.

<Examples 2 to 9>
A roll of wet tissue was obtained in the same manner as in Example 1 except that the amount of each component of the chemical solution was changed as shown in Tables 1 and 2 and the grapefruit seed extract was added as needed. It was. The winding length and basis weight of the roll of the non-woven fabric are as shown in Tables 1 and 2.

<Comparative Examples 1 to 14 >
A roll of wet tissue was obtained in the same manner as in Example 1 except that each component of the chemical solution and the amount of the chemical solution added were changed as shown in Tables 3 to 5. The winding length and basis weight of the roll of the non-woven fabric are as shown in Tables 3 to 5.

In the table, PET is polyethylene terephthalate, PP is polypropylene, PE is polyethylene, PP / PE is polypropylene / polyethylene heat-sealing fiber, and PET / PET is polyethylene terephthalate heat-sealing fiber. In addition, in formulating polyaminopropyl biguanide, Arch UK Biocides Ltd., which is a preparation containing 20% of polyaminopropyl biguanide. Cosmosyl CQ manufactured by the same company was blended so that the amount of polyaminobiguanide added was the specified amount.

<Evaluation>
The rolls of wet wipes of Examples 1 to 9 and Comparative Examples 1 to 14 were evaluated as follows.

[Preservative efficacy test (fungus)]
A fungal preservation efficacy test was conducted using a mixed bacterium of Aspergillus niger strain NBRC9455 and Candida yeast strain NBRC1594. The bacterial solutions of the above two strains were diluted with sterile physiological saline (added 0.05% by mass of polysorbate 80), and the viable cell count of each strain was 1 × 10 ⁶ cells / mL to 30 × 10 ⁶ cells / mL. A test bacterial solution was prepared. A sample of wet tissue was aseptically cut into a size of about 20 mm × 20 mm, and the sample was laminated to make 0.4 g as a test piece. The specimen was placed on the bottom of a 50 mL vial. Four vials were prepared for each sample.

The sample was cut from the central part of the wet tissue, in which the number of wet wipes contained in the roll of each wet tissue was halved. The surface of the test piece in the vial was inoculated with 0.1 mL of the test bacterial solution. The cells were stored in a desiccator at a temperature of 25 ° C. and a humidity of about 93% by mass, and one of each test bacterium was taken out on the 7th, 14th, 21st, and 28th days, and the viable cell count was measured.

To measure the viable cell count, 10 mL of sterile physiological saline was poured into a vial, mixed well with a vortex to wash out the viable cells, and the viable cell count in the washout solution was measured by GPLP agar medium mixing method. This was evaluated as follows in accordance with Category IA of the criteria of the 16th revised Japanese Pharmacopoeia Preservation Efficacy Test Method.
◯: It corresponds to category IA, and no bacteria were detected after the 7th day of inoculation (lower limit of detection: 10 / 0.4 g).
Δ: Corresponds to category IA ×: Does not correspond to category IA.

Category IA is determined based on the following criteria.
(Category IA)
14 days later: Must be at the same level as or less than the number of inoculated bacteria.
28 days later: Must be at the same level as or less than the number of inoculated bacteria.

[Preservation efficacy test (bacteria)]
Bacterial preservation efficacy tests were performed using a mixture of Escherichia coli strain NBRC3972, Pseudomonas aeruginosa strain NBRC13275, and Staphylococcus aureus strain NBRC13276. The bacterial solutions of the above three strains were diluted with sterile physiological saline to prepare a test bacterial solution having a viable cell count of 1 × 10 ⁶ cells / mL to 30 × 10 ⁶ cells / mL. A sample of wet tissue was aseptically cut into a size of about 20 mm × 20 mm, and the sample was laminated to make 0.4 g as a test piece. The specimen was placed on the bottom of a 50 mL vial. Four vials were prepared for each sample.

The sample was cut from the central part of the wet tissue, in which the number of wet wipes contained in the roll of each wet tissue was halved. The surface of the test piece in the vial was inoculated with 0.1 mL of the test bacterial solution. The cells were stored in a desiccator at a temperature of 25 ° C. and a humidity of about 93% by mass, and one of each test bacterium was taken out on the 7th, 14th, 21st, and 28th days, and the viable cell count was measured.

To measure the viable cell count, 10 mL of sterile physiological saline was poured into a vial, mixed well with a vortex to wash out the viable cells, and the viable cell count in the washout solution was measured by the SCDLP agar medium mixing method. This was evaluated as follows in accordance with Category IA of the criteria of the 16th revised Japanese Pharmacopoeia Preservation Efficacy Test Method.
◯: It corresponds to category IA, and no bacteria were detected after the 7th day of inoculation (lower limit of detection: 10 / 0.4 g).
Δ: Corresponds to category IA ×: Does not correspond to category IA.

Category IA is determined based on the following criteria.
(Category IA)
14 days later: The number of bacteria should be 0.1% or less of the number of inoculated bacteria.
28 days later ... Must be equal to or lower than the level after 14 days.

[smell]
The odor of the wet wipes of Examples and Comparative Examples was evaluated by 20 panelists. The judgment criteria are shown below.
○: 1 or less people who felt “smell worrisome” △: 2 or more and 10 or less people who felt “smell worrisome” ×: People who felt “smell worrisome” 11 or more

[Stickiness]
The stickiness of the wet wipes of Examples and Comparative Examples was evaluated by 20 panelists. The judgment criteria are shown below.
○: 1 or less people who felt “sticky” or “slimy” △: 2 or more and 10 or less people who felt “sticky” or “slimy” ×: “sticky” or “slimy” More than 11 people felt

As can be seen from Tables 1 to 5, the wet tissue of the present invention does not contain paraben, ethanol, propylene glycol, etc., but has excellent antibacterial activity against fungi, antibacterial activity against bacteria, and odor. It did not have stickiness.

<Test Example 1>
The extent to which each component of the chemical solution used for producing the roll body of the wet tissue penetrates into the roll body of the wet tissue was examined in the following test examples. 100 sheets of 130 mm × 180 mm perforated non-woven fabric having a non-woven fabric composition of 60% rayon, 25% PET, and 15% PET / PET are wound around a winding core having a diameter of 32 mm to form a roll, and 250 mass per 100 parts by mass of the non-woven fabric. The part was impregnated with the chemical solution of Example 5 (Table 6). Then, the roll body of the wet tissue was divided into three stages, an upper stage, a middle stage, and a lower stage, and the contents of sodium benzoate and benzalkonium chloride remaining in the squeezed liquid from each stage were measured. The results are shown in Table 7.

<Reference test example 1>
250 sheets of 150 mm × 300 mm perforated non-woven fabric having a non-woven fabric composition of 60% rayon, 20% PET, and 20% PP / PE are wound around a core having a diameter of 28 mm to form a roll, and the non-woven fabric is placed in a container to form a non-woven fabric. The following chemical solution (Table 8) was impregnated with 270 parts by mass per 100 parts by mass, and further inverted to allow the chemical solution to be absorbed by the non-woven fabric. After that, the roll body of the wet tissue is divided into upper, middle, and lower stages in the length direction, and is divided into the core side, the winding core, and the winding outside from the core portion in the circumferential direction, and remains in each part. The contents of benzalkonium chloride and cetylpyridinium chloride were measured. The results are shown in Tables 9 and 10. In Tables 9 and 10, the impregnation ratio (%) is a percentage of a numerical value calculated by dividing the mass of the chemical solution impregnated in the wet tissue by the mass of the non-woven fabric which is the base material of the wet tissue.

<Test Example 2>
150 pieces of 140 mm × 200 mm perforated non-woven fabric having a non-woven fabric composition of 60% rayon, 10% PET, and 30% PP / PE are wound around a core having a diameter of 32 mm to form a roll, and the non-woven fabric is placed in a container to form a non-woven fabric. The chemical solution of Example 1 (Table 11) was impregnated with 270 parts by mass per 100 parts by mass. After that, the roll body of the wet tissue is divided into upper, middle, and lower stages in the length direction, and is divided into the core side, the middle stage, and the outer stage from the core portion in the circumferential direction, and the liquid in each part is divided. The distribution of quantities was measured. The results are shown in Table 12. In Table 12, the impregnation ratio (%) is a percentage of a numerical value calculated by dividing the mass of the chemical solution impregnated in the wet tissue by the mass of the non-woven fabric which is the base material of the wet tissue.

[Evaluation]
As is clear from Tables 7, 9, 10 and 12, in the roll body of the wet tissue of the present invention, despite the large number of wet tissues, the drug component extends to the inside of the roll body. It was found that it had penetrated sufficiently and the drug had penetrated throughout the wet wipes.

Claims (7)

A roll of wet tissue in which a non-woven fabric is impregnated with a chemical solution.
The chemical solution
1.0 × 10 ^-1 % by mass or more and 2.5 × 10 ^-1 % by mass or less Sodium benzoate,
Benzalkonium chloride of 1.5 × ^10-2 % by mass or more and 2.5 × ^10-2 % by mass or less,
5.0 × 10 ^-3 % by mass or more and 1.0 × ^10-2 % by mass or less Cetylpyridinium chloride,
5.0 × 10 ^-4 % by mass or more and 1.2 × 10 ^-3 % by mass or less propynyl butylcarbamate iodide, and 4.0 × 10 ^-2 % by mass or more and 5.0 × 10 ^-2 % by mass or less Contains disodium ethylenediaminetetraacetate and dihydrate,
Contains 99.0% by mass or more of water
The drug solution does not contain paraoxybenzoic acid ester, propylene glycol, and ethanol.
A roll of wet wipes. The roll body of a wet tissue according to claim 1, wherein the chemical solution impregnated in 100 parts by mass of the non-woven fabric is 180 parts by mass or more and 350 parts by mass or less. The non-woven fabric has perforations at regular intervals perpendicular to the winding direction.
The width of the non-woven fabric sheet is 90 mm or more and 200 mm or less.
The basis weight of the non-woven fabric is 20 g / m ² or more and 50 g / m ² or less.
The roll of wet tissue according to claim 1 or 2, wherein the product of the basis weight (g / m ² ) and the winding length (m) of the non-woven fabric is 400 g / m or more and 1,000 g / m or less. The chemical solution
2.0 × 10 ^-1 % by mass or more and 2.5 × 10 ^-1 % by mass or less Sodium benzoate,
Benzalkonium chloride of 2.0 × ^10-2 % by mass or more and 2.5 × ^10-2 % by mass or less,
8.0 × 10 ^-3 % by mass or more and 1.0 × 10 ^-2 % by mass or less Cetylpyridinium chloride,
9.6 × 10 ^-4 % by mass or more and 1.2 × 10 ^-3 % by mass or less propynyl butylcarbamate iodide, and 4.0 × 10 ^-2 % by mass or more and 5.0 × 10 ^-2 % by mass or less The roll of the wet tissue according to any one of claims 1 to 3, which contains ethylenediaminetetraacetic acid disodium dihydrate. The roll of wet tissue according to any one of claims 1 to 4, wherein the chemical solution further contains a plant extract of 1.0 × 10 ^-3 % by mass or more and 1.0 × 10 ^-1 % by mass or less. The plant extracts are Artea root extract, Ononis extract, Chamomile flower extract, Sugina extract, Seiyou nokogirisou flower extract, Sage leaf extract, Celori extract, Tachijakousou flower / leaf / stem extract, Fukitanpopo extract, Melissa leaf extract, Arnica flower extract. The wet tissue according to claim 5, which is at least one selected from the group consisting of Otogirisou flower / leaf / stem extract, Seiyoukizuta leaf / stem extract, Seiyounokogirisou extract, Tokinsenka flower extract, and Grapefruit seed extract. Roll body. The roll of wet tissue according to any one of claims 1 to 6, wherein the eradication activity value is 2.0 or more for Escherichia coli and 2.0 or more for Staphylococcus aureus.