JP6833508B2 - Automatic analyzer, how to set its start time, and how to perform measurements using standard samples - Google Patents

Description

Embodiments of the present invention relate to an automatic analyzer, a method of setting a start-up time thereof, and a method of performing measurement using a standard sample.

The automatic analyzer is a device for measuring components related to test items such as biochemical test items and immunological test items contained in a sample contained in a sample container. In the automatic analyzer, the sample contained in the sample container is dispensed into the reaction tube by the sample dispensing probe. In addition, the reagent contained in the reagent storage is dispensed into the reaction tube by the reagent dispensing probe. The sample and the reagent are mixed in the reaction tube, and a predetermined component in the mixed solution of the sample and the reagent is optically measured.

If the operator has previously specified an automatic start time, the automatic analyzer starts at the specified time. Further, when the operator has specified a predetermined maintenance operation, the automatic analyzer automatically executes the specified maintenance operation.

When the maintenance operation is completed, the automatic analyzer dispenses, for example, a predetermined standard sample and prepares a calibration curve necessary for measuring the sample collected from the patient. In addition, the automatic analyzer dispenses a predetermined standard sample and carries out the measurement necessary for quality control of the calibration curve. The automatic analyzer starts the measurement of the sample collected from the patient after performing the measurement necessary for preparing the calibration curve and controlling the quality of the calibration curve.

At this time, the start of measurement of the sample collected from the patient is delayed by the time required for the preparation of the calibration curve and the measurement required for the accuracy control of the calibration curve.

Japanese Unexamined Patent Publication No. 2008-170191

The object of the embodiment is automatic that it is possible to start the measurement of the sample collected from the patient from a predetermined time in a state where the measurement necessary for the preparation of the calibration curve and the accuracy control of the calibration curve is completed. The purpose is to provide an analyzer.

According to the embodiment, the automatic analyzer includes a measurement necessity determination unit and a start-up time setting unit. When the automatic analyzer is shut down, the measurement necessity determination unit needs to perform standard sample measurement using a standard sample for at least some of the inspection items that can be measured by the automatic analyzer. To judge. The start-up time setting unit relates to the standard sample measurement so that the standard sample measurement determined to be necessary to be performed is completed by the first time specified for starting the automatic analyzer. Based on the required time, a second time representing the start-up time when the automatic analyzer is actually started is set.

FIG. 1 is a diagram showing a configuration of an automatic analyzer according to an embodiment. It is a schematic diagram which shows an example of the structure of the analysis mechanism shown in FIG. FIG. 3 is a perspective view showing the configuration of the analysis mechanism shown in FIG. FIG. 4 is a flowchart showing the operation of the control circuit when the automatic analyzer according to the embodiment sets the standard sample measurement that is automatically performed when the device is started. FIG. 5 is a flowchart showing the operation of the control circuit when the automatic analyzer according to the embodiment reserves a standard sample measurement that is automatically performed when the device is started. FIG. 6 is a diagram showing an apparatus activation setting screen for receiving a setting relating to activation of the automatic analyzer, which is displayed on the display circuit according to the embodiment. FIG. 7 is a diagram showing an expiration date management table according to the embodiment. FIG. 8 is a diagram showing a measurement reservation management table according to the embodiment. FIG. 9 is a diagram showing a setting result relating to activation of the automatic analyzer displayed on the display circuit according to the embodiment. FIG. 10 is a flowchart showing the operation of the control circuit when the automatic analyzer according to the embodiment automatically performs the measurement using the set standard sample after the device is started. FIG. 11 is a diagram showing a display example of a display circuit indicating that the standard sample measurement is being performed while the measurement using the standard sample is being performed. FIG. 12 is a diagram showing a measurement execution result displayed on the display circuit according to the embodiment. FIG. 13 is a diagram showing an apparatus activation setting screen for receiving a setting relating to activation of an automatic analyzer, which is displayed on a display circuit according to another embodiment.

Hereinafter, embodiments will be described with reference to the drawings.

FIG. 1 is a block diagram showing an example of a functional configuration of the automatic analyzer 1 according to the present embodiment. The automatic analyzer 1 shown in FIG. 1 includes an analysis mechanism 2, an analysis circuit 3, a drive mechanism 4, an input interface circuit 5, an output interface circuit 6, a storage circuit 7, and a control circuit 8.

The analysis mechanism 2 mixes a sample such as a standard sample or a test sample used as a calibrator or a control sample, and a reagent used in each test item set in this sample. The analytical mechanism 2 measures the mixed solution of the sample and the reagent, and generates, for example, standard data represented by absorbance and test data.

The analysis circuit 3 is a processor that generates a calibration curve, analysis data, and the like by analyzing the standard data generated by the analysis mechanism 2 and the test data. The analysis circuit 3 reads an operation program from the storage circuit 7 via the control circuit 8 and generates a calibration curve, analysis data, and the like according to the read operation program. For example, the analysis circuit 3 generates a calibration curve showing the relationship between the standard data and the preset standard value for the standard sample based on the standard data. Further, the analysis circuit 3 generates analysis data represented as a concentration value and an enzyme activity value based on the test data and the calibration curve of the test item corresponding to the test data. The analysis circuit 3 outputs the generated calibration curve, analysis data, and the like to the control circuit 8.

The drive mechanism 4 is realized by a gear, a stepping motor, a belt conveyor, a lead screw, and the like. The drive mechanism 4 drives the analysis mechanism 2 under the control of the control circuit 8.

The input interface circuit 5 is realized by, for example, a mouse, a keyboard, a touch pad on which instructions are input by touching an operation surface, and the like. The input interface circuit 5 receives, for example, the setting of analysis parameters and the like of each inspection item related to the sample requested to be measured by the operator. The input interface circuit 5 is connected to the control circuit 8, converts an operation instruction input from the operator into an electric signal, and outputs the electric signal to the control circuit 8. In this specification, the input interface circuit 5 is not limited to the one provided with physical operating parts such as a mouse and a keyboard. For example, an electric signal processing circuit that receives an electric signal corresponding to an operation instruction input from an external input device provided separately from the automatic analyzer 1 and outputs the electric signal to the control circuit 8 is also an input interface. It is included in the example of the circuit 5.

The output interface circuit 6 includes, for example, a display circuit 61 such as a CRT display, a liquid crystal display, an organic EL display, and a plasma display, and a printing circuit 62 such as a printer. The display circuit 61 also includes a processing circuit that converts data representing a display target into a video signal and outputs the video signal to the outside. The print circuit 62 also includes an output circuit that outputs data representing a print target to the outside. The output interface circuit 6 is connected to the control circuit 8 and outputs a signal supplied from the control circuit 8.

The display circuit 61 displays, for example, the calibration curve and analysis data supplied from the control circuit 8.

The printing circuit 62 prints the calibration curve and analysis data supplied from the control circuit 8 on printer paper or the like according to a preset format.

The storage circuit 7 includes a magnetic or optical recording medium, a recording medium such as a semiconductor memory, which can be read by a processor, and the like. The storage circuit 7 stores an operation program executed by the analysis circuit 3 and an operation program executed by the control circuit 8. The storage circuit 7 stores the calibration curve generated by the analysis circuit 3 for each inspection item. The storage circuit 7 stores the analysis data generated by the analysis circuit 3 for each test sample. Further, the storage circuit 7 stores the expiration date management table 71 and the measurement reservation management table 72.

The expiration date management table 71 is a table that stores information regarding the expiration date of the calibration curve generated for each inspection item. The expiration date management table 71 includes, for example, information indicating an inspection ID, a calibration curve level, a generation date and time, an expiration date, a calibration curve expiration date, and the like.

The inspection ID is an identifier that uniquely identifies the inspection item. The calibration curve level represents the number of measurement points when generating a calibration curve.

The generation date and time, the validity period, and the expiration date are information for confirming whether or not the calibration curve can be used. Specifically, the generation date and time represents the date and time when the calibration curve was generated by the analysis circuit 3. The expiration date represents the expiration date on which the calibration curve generated by the analysis circuit 3 can be used for measurement. Specifically, the valid period represents, for example, the time that can be used for measurement from the time of generation of the calibration curve generated by the analysis circuit 3. For example, when a calibration curve is generated by the analysis circuit 3, information indicating the inspection ID, the calibration curve level, the generation date and time, the validity period, the calibration curve expiration date, etc. related to the generated calibration curve is stored in the expiration date management table 71. To be registered in.

The measurement reservation management table 72 is a table that stores information representing measurements using a standard sample to be performed. The measurement reservation management table 72 includes, for example, information indicating an inspection ID, a measurement type, and the like. The measurement type represents the type of measurement using a standard sample. Measurements using standard samples include, for example, calibration measurements, control measurements, and the like. In the present embodiment, the calibration measurement means a measurement for creating a new calibration curve. Further, the control measurement means a measurement necessary for quality control of the created calibration curve or the already set calibration curve. For example, during the automatic shutdown operation, the inspection ID and the measurement type related to the measurement using the standard sample to be executed are registered in the measurement reservation management table 72.

The control circuit 8 is a processor that functions as the center of the automatic analyzer 1. The control circuit 8 realizes a function corresponding to this operation program by executing the operation program stored in the storage circuit 7.

FIG. 2 is a schematic diagram showing an example of the configuration of the analysis mechanism 2 shown in FIG. Further, FIG. 3 is a perspective view showing the configuration of the analysis mechanism 2 shown in FIG. The analytical mechanism 2 shown in FIGS. 2 and 3 includes a reaction disk 21 and a reagent storage 22.

The reaction disk 21 holds a plurality of reaction tubes 211 arranged in a ring shape. The reaction disk 21 is alternately rotated and stopped at predetermined time intervals by the drive mechanism 4. The reaction tube 211 is made of, for example, glass.

The reagent storage 22 cools a plurality of reagent containers 101 containing a standard sample and a reagent that reacts with a predetermined component contained in a test sample. In addition, the reagent storage 22 keeps a plurality of standard sample containers containing standard samples cold. The reagent storage 22 is provided adjacent to the reaction disk 21. In the automatic analyzer 1 shown in FIGS. 2 and 3, an example in which the reagent storage 22 is provided adjacent to the reaction disk 21 will be described, but the position where the reagent storage 22 is provided is not limited to this. Further, the reagent storage 22 is not limited to one, and a plurality of reagent storages 22 may be provided.

The reagent storage 22 holds a plurality of reagent containers 101 in a circumferential shape by means of a reagent container rack. In addition, the reagent storage 22 holds a plurality of standard sample containers in a circumferential shape by the reagent container rack in order to carry out the measurement using the standard sample. The outer circle 221 in the reagent storage 22 shown in FIGS. 2 and 3 is, for example, an opening of the reagent container 101 arranged in the outer circumference of the reagent containers 101 arranged in a circumferential shape in the reagent storage 22. Represents the position of the part. In addition, standard sample containers are arranged on the outer circumference of the reagent storage 22. The inner circle 222 in the reagent storage 22 represents, for example, the position of the opening of the reagent container 101 arranged in the inner circumference of the reagent containers 101 arranged in a circumferential shape in the reagent storage 22.

The reagent container 101 held in the reagent storage 22 contains the reagent to be dispensed into the reaction tube 211. The reagent container 101 whose opening is arranged along the outer circle 221 houses the first reagent. The reagent container in which the opening is arranged along the inner circle 222 houses the second reagent. As the first and second reagents, those used for each test item are determined. The reagent container rack is rotated around the center of the reagent storage 22 by the drive mechanism 4.

Further, the analysis mechanism 2 shown in FIGS. 2 and 3 includes a sample dispensing arm 23, a sample dispensing probe 24, a first reagent dispensing arm 25, a first reagent dispensing probe 26, and a second reagent dispensing arm. 27, a second reagent dispensing probe 28, a stirring unit 29, a photometric unit 210, a cleaning unit 201, and an electrolyte measuring unit 202 are provided.

The sample dispensing arm 23 is provided between the reaction disk 21 and the sampling lane 233. The sample dispensing arm 23 is provided by the drive mechanism 4 so as to be vertically movable in the vertical direction and rotatably in the horizontal direction. The sample dispensing arm 23 holds the sample dispensing probe 24 at one end.

The sample dispensing probe 24 rotates along an arcuate rotation trajectory as the sample dispensing arm 23 rotates. A sample suction position P1 for the sample dispensing probe 24 to suck the sample from the sample container is provided on the rotating track. The sample suction position P1 corresponds to the intersection of the rotation trajectory of the sample dispensing probe 24 and the movement trajectory of the sample container on the sampling lane 233.

Further, a sample discharge position P2 for discharging the sample sucked by the sample dispensing probe 24 to the reaction tube 211 is provided at a position on the rotation trajectory of the sample dispensing probe 24 different from the sample suction position P1. ing. The sample discharge position P2 corresponds to the intersection of the rotation locus of the sample dispensing probe 24 and the moving trajectory of the reaction tube 211 held in the reaction disk 21.

Further, at a position different from the sample suction position P1 and the sample discharge position P2 on the rotation trajectory of the sample dispensing probe 24, the diluted sample suction for the sample dispensing probe 24 to suck the standard sample from the reaction tube 211 is performed. Position P11 is provided. The diluted sample suction position P11 corresponds to an intersection other than the sample discharge position P2 between the rotation locus of the sample dispensing probe 24 and the moving trajectory of the reaction tube 211 held in the reaction disk 21.

The sample dispensing probe 24 is driven by the drive mechanism 4 and moves in the vertical direction at the sample suction position P1, the sample discharge position P2, and the diluted sample suction position P11. Further, the sample dispensing probe 24 sucks the sample from the sample container located directly below the sample suction position P1 under the control of the control circuit 8. Further, the sample dispensing probe 24 sucks the standard sample from the reaction tube 211 located directly below the diluted sample suction position P11 under the control of the control circuit 8. Further, the sample dispensing probe 24 discharges the sucked sample or the sucked standard sample to the reaction tube 211 located directly below the sample discharge position P2 under the control of the control circuit 8.

The first reagent dispensing arm 25 is provided near the outer periphery of the reagent storage 22. The first reagent dispensing arm 25 is provided by the drive mechanism 4 so as to be vertically movable in the vertical direction and rotatably in the horizontal direction. The first reagent dispensing arm 25 holds the first reagent dispensing probe 26 at one end.

The first reagent dispensing probe 26 rotates along an arcuate rotation trajectory as the first reagent dispensing arm 25 rotates. A reagent suction position P3 is provided on this rotating track. The reagent suction position P3 corresponds to the intersection of the rotation trajectory of the first reagent dispensing probe 26 and the movement trajectory of the opening of the reagent container 101 arranged on the outer circumference in the reagent storage 22. Further, on the rotation orbit of the first reagent dispensing probe 26, a first reagent discharging position P4 for discharging the reagent sucked by the first reagent dispensing probe 26 to the reaction tube 211 is set. The first reagent discharge position P4 corresponds to the intersection of the rotation trajectory of the first reagent dispensing probe 26 and the movement trajectory of the reaction tube 211 held in the reaction disk 21.

The first reagent dispensing probe 26 is driven by the drive mechanism 4 and moves in the vertical direction at the reagent suction position P3 and the first reagent discharge position P4 on the rotation orbit.

Further, the first reagent dispensing probe 26 sucks the reagent from the reagent container 101 located directly below the reagent suction position P3 under the control of the control circuit 8. Further, the first reagent dispensing probe 26 discharges the sucked reagent as the first reagent to the reaction tube 211 located directly below the first reagent discharge position P4 under the control of the control circuit 8.

Further, the first reagent dispensing probe 26 sucks a standard sample from a sample container located directly below the reagent suction position P3 under the control of the control circuit 8. Further, the first reagent dispensing probe 26 discharges the sucked standard sample to the reaction tube 211 located directly below the first reagent discharge position P4 under the control of the control circuit 8.

The second reagent dispensing arm 27 is provided near the outer periphery of the reagent storage 22. The second reagent dispensing arm 27 is provided by the drive mechanism 4 so as to be vertically movable in the vertical direction and rotatably in the horizontal direction. The second reagent dispensing arm 27 holds the second reagent dispensing probe 28 at one end.

The second reagent dispensing probe 28 rotates along an arcuate rotation trajectory as the second reagent dispensing arm 27 rotates. A reagent suction position P5 is provided on this rotating track. The reagent suction position P5 corresponds to the intersection of the rotation trajectory of the second reagent dispensing probe 28 and the movement trajectory of the opening of the reagent container 101 arranged on the inner circumference in the reagent storage 22. Further, a second reagent discharge position P6 for discharging the reagent sucked by the second reagent dispensing probe 28 into the reaction tube 211 is set on the rotation orbit of the second reagent dispensing probe 28. The second reagent discharge position P6 corresponds to the intersection of the rotation trajectory of the second reagent dispensing probe 28 and the movement trajectory of the reaction tube 211 held in the reaction disk 21.

The second reagent dispensing probe 28 is driven by the drive mechanism 4 and moves in the vertical direction at the reagent suction position P5 and the second reagent discharge position P6 on the rotation orbit. Further, the second reagent dispensing probe 28 sucks the reagent from the reagent container 101 located directly below the reagent suction position P5 under the control of the control circuit 8. Further, the second reagent dispensing probe 28 discharges the sucked reagent as the second reagent to the reaction tube 211 located directly below the second reagent discharge position P4 under the control of the control circuit 8.

The stirring unit 29 is provided near the outer periphery of the reaction disk 21. The stirring unit 29 has a first stirring arm and a first stirrer provided at the tip of the first stirring arm. The stirring unit 29 uses the first stirrer to stir the sample and the first reagent contained in the reaction tube 211 arranged at the first stirring position on the reaction disk 21. Further, the stirring unit 29 further has a second stirring arm and a second stirring element provided at the tip of the second stirring arm. The stirring unit 29 uses the second stirrer to stir the sample, the first reagent, and the second reagent contained in the reaction tube 211 arranged at the second stirring position on the reaction disk 21.

The photometric unit 210 optically measures a predetermined component in the mixed solution of the sample and the reagent discharged into the reaction tube 211. The photometric unit 210 includes a light source and a photodetector. The photometric unit 210 irradiates the reaction tube 211 with light from the light source according to the control of the control circuit 8. The photodetector detects the light that has passed through the mixture of the standard sample and the reagent in the reaction tube 211, and generates standard data represented by, for example, absorbance based on the intensity of the detected light. Further, the photodetector detects the light that has passed through the mixed solution of the test sample and the reagent in the reaction tube 211, and generates test data represented by, for example, absorbance based on the intensity of the detected light. The photometric unit 210 outputs the generated standard data and the test data to the analysis circuit 3.

The cleaning unit 201 includes, for example, a waste liquid nozzle, a cleaning nozzle, and a drying nozzle. The cleaning unit 201 sucks the mixed liquid in the reaction tube 211 delivered to the cleaning position by the rotation of the reaction disk 21 as a waste liquid by the waste liquid nozzle. The cleaning unit 201 cleans the reaction tube 211 by discharging pure water or detergent into the reaction tube 211 in which the mixed solution is sucked by the cleaning nozzle. The cleaning unit 201 dries the reaction tube 211 by supplying dry air to the washed reaction tube 211 by a drying nozzle.

The electrolyte measurement unit 202 measures the specific electrolyte present in the mixed solution in the reaction tube 211. The electrolyte measuring unit 202 measures, for example, the ion concentration generated from the specific electrolyte.

Further, the analysis mechanism 2 shown in FIGS. 2 and 3 includes a rack loading lane 220 and a rack moving unit 230. In the rack loading lane 220, a sample rack holding a predetermined number of sample containers is loaded. A standard sample or a test sample is stored in the sample container. The sample rack has a shape that can hold a predetermined number of sample containers and can be picked up by a transfer arm 231 provided in the rack moving unit 230.

The rack moving unit 230 includes a transport arm 231 and a transport rail 232, and a sampling lane 233.

The transport arm 231 is driven by the drive mechanism 4 and transports the sample rack loaded into the rack loading lane 220. For example, the transport arm 231 transports the sample rack mounted at a predetermined loading position in the rack loading lane 220 to the sampling lane 233 along the transport rail 232.

The sampling lane 233 is driven by the drive mechanism 4 and moves the sample rack conveyed by the transfer arm 231. For example, the sampling lane 233 moves the opening of each sample container held in the sample rack directly below the sample suction position P1.

The control circuit 8 shown in FIG. 1 realizes the processing according to the present embodiment by executing the operation program according to the present embodiment. Specifically, the control circuit 8 has a system control function 81, a measurement necessity determination function 82, a start-up time setting function 83, a measurement setting function 84, and a standard sample measurement function 85 by executing an operation program. In this embodiment, the case where the system control function 81, the measurement necessity determination function 82, the start-up time setting function 83, the measurement setting function 84, and the standard sample measurement function 85 are realized by a single processor will be described. , Not limited to this. For example, a control circuit is configured by combining a plurality of independent processors, and each processor executes an operation program to execute a system control function 81, a measurement necessity determination function 82, a start-up time setting function 83, a measurement setting function 84, and the like. The standard sample measurement function 85 may be realized.

The system control function 81 is a function that controls each part of the automatic analyzer 1 in an integrated manner based on the input information input from the input interface circuit 5. For example, in the system control function 81, the control circuit 8 executes an automatic shutdown operation based on a shutdown instruction input from the input interface circuit 5. The automatic shutdown operation includes a set of preset processes required for maintenance before the power is turned off.

Further, the control circuit 8 starts the activation process of the automatic analyzer 1 at a preset time. The activation process of the automatic analyzer 1 includes turning on the power of the automatic analyzer 1 and starting up the OS (operation system) included in the automatic analyzer 1. The control circuit 8 executes an automatic start-up operation when the start-up process of the automatic analyzer 1 is completed. The automatic start-up operation includes preset maintenance operations required for starting measurement, for example, operation confirmation of each unit included in the automatic analyzer 1, and cleaning operation for cleaning the reaction tube 211 held in the reaction disk 21. Etc. are included.

The measurement necessity determination function 82 is a function for determining whether or not to perform calibration measurement and control measurement for a predetermined inspection item. Specifically, the control circuit 8 determines whether or not calibration measurement for all the inspection items is necessary based on the expiration date of the calibration curve for all the inspection items that can be measured by the automatic analyzer 1. judge. Further, the control circuit 8 is, for example, an instruction input from the operator via the input interface circuit 5, and the calibration is based on an instruction indicating whether or not to carry out the calibration measurement related to a predetermined inspection item. Determine if the measurement is to be performed. Further, the control circuit 8 is an instruction input from the operator via, for example, the input interface circuit 5, and the control measurement is performed based on an instruction indicating whether or not to perform the control measurement related to a predetermined inspection item. Determine whether to implement.

The control circuit 8 needs to perform calibration measurement related to some of the inspection items based on the expiration date of the calibration curve related to some of the inspection items that can be measured by the automatic analyzer 1. It may be determined whether or not it is. Some inspection items are inspection items designated by the operator, for example, via the input interface circuit 5.

The start-up time setting function 83 is a function of calculating the retroactive time required from the time specified in advance to the time when the device is actually started, and setting the time when the automatic analyzer 1 is actually started. The retroactive time is, for example, the time from the start-up of the automatic analyzer 1 to the completion of the measurement using the standard sample, the time required for the start-up process of the automatic analyzer 1 (automatic start-up processing time), and the time required for the automatic start-up operation. Includes time (automatic start-up time) and time required for measurement using a standard sample (preceding standard sample measurement completion time). The control circuit 8 may calculate only the time required for the measurement using the standard sample as the retroactive time.

For example, in the start-up time setting function 83, the control circuit 8 adds the time required for the start-up process of the automatic analyzer 1, the time required for the automatic start-up operation, and the time required for the measurement using the standard sample. Calculate the retroactive time. The time required for the start-up process of the automatic analyzer 1 includes the time required for turning on the power of the automatic analyzer 1 and starting up the OS included in the automatic analyzer 1. The time required for the automatic start-up operation includes the time required for executing the maintenance operation or the like preset as the automatic start-up operation.

The time required for measurement using a standard sample includes a standard sample measurement start-up time, a calibration measurement dispensing time, a control measurement dispensing time, and a reaction time.

The standard sample measurement start-up time is the time required for the start-up operation to start the measurement using the standard sample. The standard sample measurement start-up time is required to perform, for example, constant temperature water exchange, constant temperature bath additive injection, reaction tube cleaning, probe cleaning, stirrer cleaning, electrode cleaning, electrode calibration solution exchange, air purge, and the like. The time and the waiting time required for the temperature of the constant temperature water to rise to a predetermined temperature are included.

The air purge is, for example, a process of pushing out air bubbles in the syringe connected to one end of the sample dispensing probe 24 and in the flow path thereof from the sample dispensing probe 24, and is connected to one end of the first reagent dispensing probe 26. The process of pushing out the bubbles in the syringe and the flow path thereof from the first reagent dispensing probe 26, and the bubbles in the syringe connected to one end of the second reagent dispensing probe 28 and in the flow path thereof are the first. 2 Reagent dispensing A process of extruding from the probe 28 or the like.

The waiting time required for the temperature of the constant temperature water to rise to a predetermined temperature is the waiting time from the completion of the constant temperature water exchange to the rise of the temperature of the constant temperature water to the predetermined temperature. When the constant temperature water exchange is not performed, about 10 minutes from the start-up of the automatic analyzer 1 is included in the standard sample measurement start-up time as the waiting time required for the temperature of the constant temperature water to rise to a predetermined temperature.

The calibration measurement dispensing time is the time required for the dispensing operation of the calibrator and the reagent required for the calibration measurement. The control circuit 8 calculates the calibration measurement dispensing time based on, for example, the number of inspection items and the calibration curve level. The number of inspection items is, for example, the number of inspections that need to be performed on one sample for which measurement is requested.

The control measurement dispensing time is the time required for the dispensing operation of the control sample and the reagent required for the control measurement. The control circuit 8 calculates the control measurement dispensing time based on, for example, the number of inspection items.

The reaction time is the time for reacting the standard sample with the reagent corresponding to the standard sample. The reaction time is the measurement result after the reagent dispensing operation is completed among the last dispensing operations required for calibration measurement or control measurement when calculating the time required for measurement using a standard sample. Is added as the time until is displayed.

If the calibration measurement is not performed, the calibration measurement dispensing time is not included in the time required for the measurement using the standard sample. In addition, when the control measurement is not performed, the control measurement dispensing time is not included in the time required for the measurement using the standard sample.

The measurement setting function 84 is a function for setting the calibration measurement and / and the control measurement to be executed after the automatic start-up operation. Specifically, the control circuit 8 associates the calibration measurement and / and the control measurement, which are determined by the measurement necessity determination function 82 to be necessary for the predetermined inspection item, with the inspection item, and the storage circuit 7 It is registered in the measurement reservation management table 72 stored in.

The standard sample measurement function 85 is a function of performing calibration measurement and / and control measurement when the automatic start-up operation is completed. Specifically, the control circuit 8 identifies the calibration measurement and / and the calibration measurement to be performed from the record related to the calibration measurement and / and the control measurement registered in the measurement reservation management table 72. When the automatic start-up operation is completed, the control circuit 8 executes the specified calibration measurement and / and the control measurement for each inspection item.

Next, the operation when the automatic analyzer 1 configured as described above registers the calibration measurement and / and the control measurement in the measurement reservation management table 72 will be described with reference to FIGS. 4 and 5. 4 and 5 are examples of a flowchart showing the operation of the control circuit 8 when the automatic analyzer 1 according to the present embodiment registers the calibration measurement and / and the control measurement in the measurement reservation management table 72.

Hereinafter, in the description of FIGS. 4 and 5, the automatic analyzer 1 shall perform the operations shown in FIGS. 4 and 5 during the automatic shutdown operation. It is assumed that the automatic analyzer 1 is set to be automatically started at a preset time.

The control circuit 8 determines whether or not the automatic analyzer 1 is set to be automatically started when a shutdown instruction is input via the input interface circuit 5 (step SA1).

When the control circuit 8 determines that the automatic analyzer 1 is not set to be automatically started (No in step SA1), the control circuit 8 ends the process.

When the control circuit 8 determines that the automatic analyzer 1 is set to be automatically started (Yes in step SA1), the control circuit 8 controls the display circuit 61 to receive the setting related to the start processing of the automatic analyzer 1. Display the device startup setting screen of. The control circuit 8 receives a setting related to the activation process of the automatic analyzer 1 via the input interface circuit 5 (step SA2). FIG. 6 is a diagram showing an example of a device activation setting screen displayed on the display circuit 61 according to the present embodiment.

On the device start setting screen shown in FIG. 6, for example, an automatic start time (first time) and an operation end time can be set. The automatic start time is a time when the automatic analyzer 1 is automatically started, and is designated by an operator, for example, via the input interface circuit 5. The operation end time is, for example, the time when the measurement of the sample collected from the patient is scheduled to end.

For example, the device start setting screen shown in FIG. 6 is provided with input areas for an automatic start time and an operation end time, respectively. The operator can set the automatic start time and the operation end time by inputting a number into the input area via the input interface circuit 5. In the example of FIG. 6, the automatic start time is set to "2016/10/11 8:00" and the operation end time is set to "2016/10/11 18:00". At this time, the operation time, that is, the time from the set automatic start time to the operation end time is 10 hours.

Further, on the device activation setting screen shown in FIG. 6, it is possible to set whether or not to carry out the calibration measurement for each inspection item. For example, on the device activation setting screen shown in FIG. 6, calibration measurement is performed on the right side of one column in which the inspection IDs “A”, “B”, “C”, and “D” are displayed. There is a check box that allows you to set whether or not.

The operator can set whether or not to carry out the calibration measurement by inputting "check" in the check box via the input interface circuit 5. In the example of FIG. 6, the calibration measurement is set to "valid" for the inspection IDs "A", "B", "C", and "D".

Further, on the device activation setting screen shown in FIG. 6, it is possible to set whether or not to perform control measurement for each inspection item. For example, on the device activation setting screen shown in FIG. 6, whether to perform control measurement on the right side of two columns in which the inspection IDs "A", "B", "C", and "D" are displayed. There is a check box that can be set whether or not.

The operator can set whether or not to perform the control measurement by inputting "re" in the check box via the input interface circuit 5. In the example of FIG. 6, for the inspection ID “A”, the execution of the calibration measurement is set to “valid”. Further, in the example of FIG. 6, the calibration measurement is set to "invalid" for the inspection IDs "B", "C", and "D".

Further, the confirmation button B1 is displayed on the device activation setting screen shown in FIG. For example, when the cursor is placed on the confirmation button B1 shown in FIG. 6 via the input interface circuit 5, the automatic start time, the operation end time, and the settings related to the calibration measurement and the control measurement in each inspection item are accepted. Be done.

The control circuit 8 executes the measurement necessity determination function 82 when the setting related to the activation of the automatic analyzer 1 is accepted. By executing the measurement necessity determination function 82, the control circuit 8 acquires information on the expiration date of the calibration curve created for each inspection item (step SA3). Specifically, the control circuit 8 reads out all the records registered in the expiration date management table 71 stored in the storage circuit 7.

FIG. 7 is a diagram showing an example of the expiration date management table 71 according to the present embodiment. As shown in FIG. 6, in the expiration date management table 71, "inspection ID: A", "calibration curve level: 4", "generation date and time: 2016/10/8 15:00", "validity period: 72" , And "Calibration curve expiration date: 2016/10/11 15:00" are registered. In addition, "inspection ID: B", "calibration curve level: 4", "generation date and time: 2016/10/7 10:00", "validity period: 120", and "calibration curve expiration date: 2016/10/12" "10:00" is registered. In addition, "inspection ID: C", "calibration curve level: 9", "generation date and time: 2016/10/8 15:00", "validity period: 72", and "calibration curve expiration date: 2016/10/11" 15:00 "is registered. In addition, "inspection ID: D", "calibration curve level: 9", "generation date and time: 2016/10/9 17:00", "validity period: 120", and "calibration curve expiration date: 2016/10/14" 17:00 "is registered.

The control circuit 8 reads one record from the acquired information on the expiration date (step SA4). For example, the control circuit 8 reads a record whose inspection ID is “A”.

The control circuit 8 determines whether or not the expiration date of the calibration curve of the read record expires within a predetermined time from the automatic start time set in step SA2 (step SA5). The predetermined time is set in advance according to, for example, the operating time. The predetermined time may be shorter than the operating time. The control circuit 8 is an operating time from the automatic start time “2016/10/11 8:00” set in step SA2 by referring to the expiration date item of the record whose read inspection ID is “A”, for example. Determine if the expiration date will expire within an hour. The start time of the determination as to whether or not the expiration date expires is the time when the shutdown instruction is scheduled to be input, for example, the operation end time "2016/10/10 18:00".

In the control circuit 8, the expiration date “2016/10/11 15:00” of the record whose read inspection ID is “A” is the automatic start time “2016/10/11 8:00” set in step SA2. Since it is within 10 hours from the above, it is determined that the expiration date has expired (Yes in step SA5). The control circuit 8 sets the inspection ID “A” as an inspection ID representing an inspection item that requires calibration measurement (step SA6).

The control circuit 8 determines whether or not the set value of whether or not to carry out the calibration measurement for the set inspection ID is valid (step SA7). The control circuit 8 may determine whether or not the set value of whether or not to carry out the calibration measurement is valid before step SA5.

In the control circuit 8, since "re" is entered in the check box related to the calibration measurement of the inspection ID "A" shown in FIG. 6, it is effective to carry out the calibration measurement for the inspection ID "A". Judgment (Yes in step SA7), and as shown in FIG. 8, by executing the measurement setting function 84, a record having the inspection ID “A” and the measurement type “calibration measurement” is registered in the measurement reservation management table 72. (Step SA8).

The control circuit 8 determines whether or not the set value of whether or not to perform the control measurement is valid for the read inspection ID “A” (step SA9).

Since the control circuit 8 has entered a check box for the control measurement of the inspection ID “A” shown in FIG. 6, it is determined that the setting related to the control measurement for the inspection ID “A” is valid. (Yes in step SA9), as shown in FIG. 8, by executing the measurement setting function 84, a record having the inspection ID “A” and the measurement type “control measurement” is registered in the measurement reservation management table 72 (step SA10). ).

The control circuit 8 determines whether or not among the records read from the expiration date management table 71 in step SA2, there are other records for which calibration measurement and / and control measurement is not necessary or not determined. (Step SA11).

When another record that has not been determined exists (Yes in step SA11), the control circuit 8 reads one record from the record read in step SA2 (step SA4), and repeats the processes from step SA5 to step SA11.

For example, among the records shown in FIG. 7, the control circuit 8 reads out the record having the inspection ID “B” because the record having the inspection ID “B” has not been determined (step SA4).

The control circuit 8 determines whether or not the expiration date of the calibration curve of the read record expires from the automatic start time set in step SA2 to the time when a predetermined time elapses (step SA5). For example, the control circuit 8 refers to the expiration date item of the record whose read inspection item is "B", and whether or not the expiration date expires within 10 hours from the automatic start time "2016/10/11 8:00". judge.

Since the expiration date of the record whose read inspection ID is "B" is "2016/10/12 10:00", the control circuit 8 determines that the expiration date does not expire (No in step SA5). The control circuit 8 determines whether or not the set value of whether or not to perform the control measurement on the read record with the inspection ID “B” is valid (step SA9).

In the control circuit 8, since a null value is entered in the check box related to the control measurement of the inspection ID “B” shown in FIG. 6, that is, “re” is not entered, the control measurement is performed for the inspection ID “B”. It is determined that the set value of whether or not to execute is invalid (No in step SA9), and among the records read from the expiration date management table 71 in step SA2, calibration measurement and / and control measurement are required. It is determined whether or not there is another record that has not been determined to be present (step SA11).

The control circuit 8 reads one record from the record read from the expiration date management table 71 in step SA2 (step SA4), and repeats the processes from step SA5 to step SA11 for the record having the inspection ID “C” that has not been determined. .. As a result, as shown in FIG. 8, by executing the measurement setting function 84, for example, a record having the inspection ID “C” and the measurement type “calibration measurement” is registered in the measurement reservation management table 72.

Further, the control circuit 8 reads one record from the record read from the expiration date management table 71 in step SA2 (step SA4), and processes from step SA5 to step SA11 to read the record having the undetermined inspection ID “D”. repeat.

The control circuit 8 executes the start-up time setting function 83 when there is no other record that has not been determined (No in step SA11). By executing the start-up time setting function 83, the control circuit 8 calculates the required time for the measurement using the standard sample based on the measurement registered in the measurement reservation management table 72 (step SA12).

Specifically, in the control circuit 8, the calibration measurement related to the inspection ID "A", the control measurement related to the inspection ID "A", and the control measurement related to the inspection ID "C" are registered in the measurement reservation management table 72. Therefore, the standard sample measurement start-up time, the calibration measurement dispensing time, the control measurement dispensing time, and the reaction time are added to calculate the required time for the measurement using the standard sample. The standard sample measurement start-up time is preset to, for example, 900 seconds.

The control circuit 8 refers to the expiration date management table 71 and the measurement reservation management table 72, and calculates the calibration measurement dispensing time.

Specifically, the control circuit 8 refers to the measurement reservation management table 72 shown in FIG. 7 and recognizes that the inspection ID “A” needs to be calibrated. The control circuit 8 refers to the expiration date management table 71 shown in FIG. 7, and recognizes that the calibration curve level related to the inspection ID “A” is “4”. When the calibration curve level is "4", five different concentrations of standard sample are used, including the blank measurement. When the number of repetitions of the measurement for one standard sample is set to 4 and the cycle time is set to 4.5 seconds, the control circuit 8 sets the calibration measurement dispensing time to 4.5 × 5. Calculate as × 4 = 90 seconds. The control circuit 8 takes the average value or the median value of the results of repeated measurements of the same standard sample. This makes it possible to improve the accuracy of measurement. The number of repetitions may be 2, 3, or 5 or more.

When high accuracy is required for dispensing the standard sample, for example, a small amount of the standard sample that cannot be accurately dispensed by the first reagent dispensing probe 26 must be dispensed and measured. In this case, it may be necessary to transfer the standard sample discharged from the first reagent dispensing probe 26 to the reaction tube 211 using the sample dispensing probe 24. In this case, the control circuit 8 calculates the calibration measurement dispensing time as, for example, 90 × 2 = 180 seconds.

Further, the control circuit 8 refers to the measurement reservation management table 72 shown in FIG. 8 and recognizes that the inspection ID “C” requires calibration measurement. The control circuit 8 refers to the expiration date management table 71 shown in FIG. 7, and recognizes that the calibration curve level related to the inspection ID “C” is “9”. When the calibration curve level is "9", 10 standard samples with different concentrations are used, including the blank measurement. When the number of repetitions of the measurement for one standard sample is set to 4 and the cycle time is set to 4.5 seconds, the control circuit 8 sets the calibration measurement dispensing time to 4.5 × 10. It is calculated as × 4 = 180 seconds.

The control circuit 8 refers to the measurement reservation management table 72 and calculates the control measurement dispensing time.

Specifically, the control circuit 8 refers to the measurement reservation management table 72 shown in FIG. 8 and recognizes that the control measurement is necessary for the inspection ID “A”. For control measurements with respect to test ID "A", for example, five different concentrations of standard samples are used. The number of standard samples with different concentrations is preset, for example, for each test item. When the number of repeated measurements for one standard sample is set to 4 and the cycle time is set to 4.5 seconds, the control circuit 8 sets the control measurement dispensing time to 4.5 × 5 ×. Calculate as 4 = 90 seconds.

Based on the above, the calibration measurement dispensing time related to the calibration measurement registered in the measurement reservation management table 72 is calculated to be 270 seconds, which is the sum of 90 seconds and 180 seconds. Further, the control measurement dispensing time related to the control measurement registered in the measurement reservation management table 72 is calculated to be 90 seconds.

The reaction time is preset to, for example, 600 seconds. Therefore, when calculating the time required for measurement using the standard sample, the reaction time of 600 seconds is added after the completion of the final reagent dispensing in the control measurement for test ID “C”.

The control circuit 8 adds the standard sample measurement start-up time of 900 seconds, the calibration measurement dispensing time of 270 seconds, the control measurement dispensing time of 90 seconds, and the reaction time of 600 seconds, and the time required for measurement using the standard sample is 1860. Calculate the seconds.

Subsequently, when the time required for the start processing of the automatic analyzer 1 is set to 300 seconds and the time required for the automatic start-up operation is set to 1200 seconds, the control circuit 8 registers these periods. The retroactive time of 3360 seconds is calculated by adding to the required time of 1860 seconds for the measurement using the standard sample (step SA13).

After calculating the retroactive time, the control circuit 8 corrects (sets) the automatic start time set in step SA2 (step SA14). For example, since the automatic start time of the control circuit 8 is set to "2016/10/11 8:00" in step SA2, 3360 seconds calculated in step SA11, that is, 56 minutes is subtracted from this time to automatically start the control circuit 8. The startup time is corrected from "2016/10/11 8:00" to "2016/10/11 7:04".

Finally, the control circuit 8 controls the display circuit 61 and displays the setting result regarding the activation of the automatic analyzer 1 (step SA14). FIG. 9 is a diagram showing an example of a setting result relating to activation of the automatic analyzer 1 displayed on the display circuit 61 according to the present embodiment. As shown in FIG. 9, the setting results relating to the activation of the automatic analyzer 1 include, for example, for each inspection item, the measurement type of the measurement using the registered standard sample, the sample required for the measurement, the first reagent, and the like. And the second reagent are displayed.

Specifically, for the test ID "A" shown in FIG. 9, the measurement type "calibration measurement", the sample "X", the first reagent "X1", and the second reagent "X2" are displayed. .. Further, regarding the test ID “A” shown in FIG. 9, the measurement type “control measurement”, the sample “Y”, the first reagent “X1”, and the second reagent “X2” are displayed. Further, regarding the test ID “C” shown in FIG. 9, the measurement type “calibration measurement”, the sample “Z”, the first reagent “Z1”, and the second reagent “Z2” are displayed.

Further, the letters of the sample "Y", the first reagent "X1", and the first reagent "Z1" shown in FIG. 9 are underlined. This underline shows a sample container containing the sample "Y" required for measurement, a reagent container 101 containing the first reagent "X1", and a reagent container 101 containing the first reagent "Z1" in the automatic analyzer 1. Indicates that it is not placed.

Further, the characters of the second reagent "X2" and the second reagent "Z2" shown in FIG. 9 are displayed in outline characters. The outline characters indicate, for example, 10 hours, which is the time during which the measurement of the sample collected from the patient is performed at the automatic start time "2016/10/11 8:00" set in step SA2 of FIG. It indicates that the expiration date of the second reagent "X2" and the second reagent "Z2" will expire by the added time "2016/10/11 18:00".

Further, the display circuit 61 shown in FIG. 9 displays the automatic start time before the change and the automatic start time after the change. The automatic start time before change is, for example, the automatic start time (first time) input via the input interface circuit 5 on the device start setting screen shown in FIG. The automatic start time after the change is, for example, the time obtained by subtracting the retroactive time from the automatic start time before the change. In the example of FIG. 9, the automatic start time before change is displayed as "October 11, 2016, 08:00". In addition, the automatic start time after the change is displayed as "07:04 on October 11, 2016". This makes it possible to clearly confirm the time when the automatic analyzer 1 is actually started.

The control circuit 8 may display the time obtained by subtracting the time required for the measurement using the standard sample from the automatic start time before the change as the automatic start time after the change on the display circuit 61. Further, the control circuit 8 may display the time required for the measurement using the standard sample on the display circuit 61.

The setting result regarding the activation of the automatic analyzer 1 may be printed on printer paper or the like by the printing circuit 62.

Further, the display circuit 61 shown in FIG. 9 displays a consent button B2 for prompting the operator to consent to the setting result relating to the activation of the automatic analyzer 1. When the cursor is placed on the consent button B2 shown in FIG. 9, the content of the setting result regarding the activation of the automatic analyzer 1 is confirmed.

Next, the operation when the automatic analyzer 1 automatically performs the reserved standard sample measurement after the device is started will be described with reference to FIG. FIG. 10 is an example of a flowchart showing the operation of the control circuit 8 when the automatic analyzer 1 according to the present embodiment automatically performs the set standard sample measurement after the device is started.

The control circuit 8 executes the system control function 81 at the start time “2016/10/11 7:04” of the automatic analyzer 1 modified in step SA14 shown in FIG. By executing the system control function 81, the control circuit 8 starts starting the automatic analyzer 1, that is, turning on the power of the automatic analyzer 1, starting up the OS included in the automatic analyzer 1, and the like (step SB1).

The control circuit 8 executes an automatic start-up operation after the automatic analyzer 1 is started (step SB2).

When the automatic start-up operation is completed, the control circuit 8 refers to the measurement reservation management table 72 and determines whether or not the registered calibration measurement and / or control measurement exists (step SB3).

The control circuit 8 executes the standard sample measurement function 85 when the registered calibration measurement and / or control measurement exists (Yes in step SB3). By executing the standard sample measurement function 85, the control circuit 8 performs the calibration measurement and / or the control measurement (step SB4). For example, the control circuit 8 carries out the calibration measurement related to the inspection ID “A” shown in FIG. 8, the control measurement related to the inspection ID “A”, and the calibration measurement related to the inspection ID “C”. The control circuit 8 controls the display circuit 61 and displays that "standard sample measurement is being performed". FIG. 11 is a diagram showing a display example of the display circuit 61 that indicates that the standard sample measurement is being performed while the measurement using the standard sample is being performed.

In the example of FIG. 11, in the display circuit 61, the area representing the calibration measurement related to the inspection ID “A” is highlighted with diagonal lines. This highlight display indicates that the calibration measurement related to the inspection ID "A" is being performed. Further, in the example of FIG. 11, it is shown that the control measurement related to the inspection ID “A” and the calibration measurement related to the inspection ID “C”, which are not highlighted by diagonal lines, are not being performed. The measurement is performed in the order of, for example, the calibration measurement related to the inspection ID "A", the control measurement related to the inspection ID "A", and the calibration measurement related to the inspection ID "C". As a result, even if the automatic analyzer 1 is started at a time not expected by the operator, the measurement using the standard sample can be performed without astonishing the operator.

After performing all the registered calibration measurement and / or control measurement, the control circuit 8 controls the display circuit 61 and displays the measurement execution result (step SB5). FIG. 12 is a diagram showing an example of measurement execution results displayed on the display circuit 61 according to the present embodiment. As shown in FIG. 12, in the measurement execution result, for example, the measurement type of the measurement performed and the implementation result are displayed for each inspection item.

Specifically, the result "end" is displayed for the inspection ID "A" shown in FIG. 12 and the measurement type "calibration measurement". Further, for the inspection ID "A" shown in FIG. 12 and the measurement type "control measurement", the result "end" is displayed. In addition, the result "end" is displayed for the inspection ID "C" shown in FIG. 12 and the measurement type "calibration measurement". That is, in the example of FIG. 12, it is shown that all the measurements were completed without any problem.

If all or part of the measurement ends abnormally, the value in the "Result" column shown in FIG. 12 related to the abnormally completed measurement is displayed as "Failure" to the operator. It may be notified.

The control circuit 8 ends the process when the registered calibration measurement and / or the control measurement does not exist (No in step SB3). As a result, the process required to start the measurement of the sample collected from the patient is completed by the automatic start time set in step SA2 of FIG.

According to the above embodiment, when the automatic analyzer 1 is shut down, the control circuit 8 determines whether or not it is necessary to carry out measurement using a standard sample for a predetermined inspection item. The control circuit 8 used a standard sample determined by the measurement necessity determination function 82 to be performed by the pre-change automatic start time (first time) set via the input interface circuit 5. By modifying the set automatic start time (first time) based on the time required for measurement using the standard sample so that the measurement is completed, the changed automatic start time (second time) To set.

This makes it possible to complete the measurement using the standard sample required for the measurement of the sample collected from the patient by the pre-change automatic start time (first time) set via the input interface circuit 5. It becomes. Further, even if there are a large number of measurements using the standard sample determined to be necessary, the control circuit 8 uses the standard sample in consideration of the number of inspection items, the inspection level, and the like. Since the required time for the measured measurement is calculated, the measurement using the standard sample can be reliably completed by the set pre-change automatic start time (first time).

Therefore, according to the automatic analyzer according to the present embodiment, the measurement of the sample collected from the patient from the time specified in advance is completed in the state where the measurement necessary for the preparation of the calibration curve and the accuracy control of the calibration curve is completed. Can be started.

Further, according to the above embodiment, the control circuit 8 performs the calibration measurement and the control measurement registered in the measurement reservation management table 72 after the device is started at the changed automatic start time (second time). carry out. As a result, it is possible to save the operator the trouble of performing the calibration measurement and the control measurement after the automatic analyzer 1 is automatically started.

Further, according to the above embodiment, the control circuit 8 controls the display circuit 61, and the standard sample, the first reagent, and the second reagent necessary for the reserved calibration measurement and the control measurement for each inspection item. Is displayed. As a result, it is possible to prevent the calibration measurement and the measurement related to the control measurement from failing due to misplacement of the standard sample and / or the reagent.

Further, according to the above embodiment, the control circuit 8 controls the display circuit 61 and displays the automatic start time (second time) after the change. As a result, the operator can clearly grasp the start-up time of the automatic analyzer 1.

Further, according to the above embodiment, the calibration curve of the control circuit 8 expires within 10 hours, which is the same as the operating time, from the automatic start time (first time) set via the input interface circuit 5. Judge whether or not. As a result, for example, there is no calibration curve that expires by the operation end time. Therefore, it is possible to continue the measurement of the sample collected from the patient without interrupting the operation by performing the calibration measurement or the like.

[Other Embodiments]
The present invention is not limited to the above embodiment. For example, in the above embodiment, the calibration measurement dispensing time is calculated based on the number of inspection items and the calibration curve level set for each inspection item, but is not limited thereto. That is, a preset value may be used for the calibration measurement dispensing time.

In addition, the control measurement dispensing time was calculated based on the number of inspection items, but is not limited to this. That is, a preset value may be used for the control measurement dispensing time.

Further, in the above embodiment, the method of determining whether or not the expiration date of the calibration curve expires has been described by taking as an example the case where the predetermined predetermined time is 10 hours, which is the same as the operating time, but the present invention is not limited to this. .. For example, the preset predetermined time may be less than 10 hours, which is shorter than the operating time. In this case, for example, by setting the start time of the calibration measurement registered in the measurement reservation management table 72 to the time immediately before the expiration date of the calibration curve corresponding to the calibration measurement, the valid period is shorter than the operating time. Even if it is a calibration curve, it is possible to automatically perform calibration measurement. This makes it possible to save the operator the trouble of performing calibration measurement and control measurement during the operation time.

Further, in the above embodiment, the timing at which the setting related to the activation of the automatic analyzer 1 is accepted is not limited to the time of the automatic shutdown operation, that is, the timing of step SA2 shown in FIG. That is, the setting contents on the device start setting screen shown in FIG. 6 may be accepted in advance at a predetermined timing other than the automatic shutdown operation.

Further, in the above embodiment, the control circuit 8 accepts the setting of the automatic start time, which is the time when the automatic analyzer 1 is automatically started, on the device start setting screen shown in FIG. Not limited. FIG. 13 is a diagram showing an example of a device activation setting screen for accepting a setting related to activation of the automatic analyzer 1 displayed on the display circuit 61 according to another embodiment. For example, on the device activation setting screen shown in FIG. 13, a setting item of "standard sample measurement completion time" is displayed instead of the "automatic activation time" shown in FIG. When the "standard sample measurement completion time" is set via the input interface circuit 5, the control circuit 8 automatically starts the automatic analyzer 1 by subtracting the retroactive time from the set "standard sample measurement completion time". Set the time of. As a result, the operator can start the measurement of the sample collected from the patient from the set "standard sample measurement completion time".

The word "processor" used in the above description means, for example, a CPU (central processing unit), a GPU (Graphics Processing Unit), an integrated circuit for a specific application (Application Specific Integrated Circuit: ASIC)), or a programmable logic device (for example, , Simple Programmable Logic Device (SPLD), Complex Programmable Logic Device (CPLD), and Field Programmable Gate Array (FPGA)). The processor realizes the function by reading and executing the program stored in the storage circuit. It should be noted that each processor of the present embodiment is not limited to the case where each processor is configured as a single circuit, and a plurality of independent circuits may be combined to form one processor to realize its function. Good. Further, the plurality of components in FIG. 1 may be integrated into one processor to realize the function.

Although some embodiments of the present invention have been described, these embodiments are presented as examples and are not intended to limit the scope of the invention. These embodiments can be implemented in various other forms, and various omissions, replacements, and changes can be made without departing from the gist of the invention. These embodiments and modifications thereof are included in the scope and gist of the invention, as well as in the scope of the invention described in the claims and the equivalent scope thereof.

1 ... Automatic analyzer, 2 ... Analysis mechanism, 3 ... Analysis circuit, 4 ... Drive mechanism, 5 ... Input interface circuit, 6 ... Output interface circuit, 7 ... Storage circuit, 8 ... Control circuit, 21 ... Reaction disk, 22 ... Reagent storage, 23 ... sample dispensing arm, 24 ... sample dispensing probe, 25 ... first reagent dispensing arm, 26 ... first reagent dispensing probe, 27 ... second reagent dispensing arm, 28 ... second reagent dispensing Note Probe, 29 ... Stirring unit, 61 ... Display circuit, 62 ... Printing circuit, 71 ... Expiration date management table, 72 ... Measurement reservation management table, 81 ... System control function, 82 ... Measurement necessity judgment function, 83 ... Start time Setting function, 84 ... Measurement setting function, 85 ... Standard sample measurement function, 101 ... Reagent container, 201 ... Cleaning unit, 202 ... Electrolyte measurement unit, 210 ... Photometric unit, 211 ... Reaction tube, 220 ... Rack input lane, 221 ... Outer circle, 222 ... inner circle, 230 ... rack moving unit, 231 ... transfer arm, 232 ... transfer rail, 233 ... sampling lane.

Claims (16)

When the automatic analyzer is shut down, it is necessary to determine the necessity of performing standard sample measurement using a standard sample for at least some of the inspection items that can be measured by the automatic analyzer. Department and
Based on the time required for the standard sample measurement, the standard sample measurement determined to be required to be performed is completed by the first time specified to activate the automated analyzer. An automatic analyzer including a start-up time setting unit that sets a second time representing the start-up time when the automatic analyzer is actually started. The automatic analyzer according to claim 1, further comprising a system control unit that activates the automatic analyzer at the set second time. The automatic analyzer according to claim 2, further comprising a standard sample measurement unit that performs the standard sample measurement determined to be necessary after the system control unit activates the automatic analyzer. The automatic analyzer according to claim 1, further comprising an output interface unit for outputting information on a standard sample and a reagent related to the standard sample measurement determined to be necessary. The automatic analyzer according to claim 1, further comprising an output interface unit that outputs the set second time. The automatic analyzer according to claim 3, further comprising an output interface unit for outputting the execution result of the standard sample measurement determined to be necessary. From the first time, the start-up time setting unit has determined that the time required for starting the automatic analyzer, the time required for the automatic start-up operation of the automatic analyzer, and the execution are necessary. The automatic analyzer according to any one of claims 1 to 6, wherein the second time is calculated by subtracting the time required for standard sample measurement. The standard sample measurement determined to be necessary is a calibration measurement for creating a calibration curve for a predetermined test item.
The measurement necessity determination unit performs the calibration measurement based on the expiration date of the calibration curve of at least some of the inspection items measurable by the automatic analyzer and the first time. The automatic analyzer according to any one of claims 1 to 7, which determines whether or not it is necessary. The automatic analyzer according to claim 8, wherein the measurement necessity determination unit determines whether or not the calibration measurement is necessary based on the operation time or the operation end time of the device. The standard sample measurement determined to be necessary is according to claim 8 or 9 , wherein the standard sample measurement for determining whether or not the calibration measurement is necessary is based on the setting of necessity for the calibration measurement. Automatic analyzer. The standard sample measurement determined to be necessary is the calibration measurement and the control measurement for controlling the accuracy of the inspection line generated by the calibration measurement.
The automatic analyzer according to any one of claims 8 to 10, wherein the measurement necessity determination unit determines whether or not the control measurement is necessary based on the setting of necessity regarding the control measurement. The automatic analyzer according to claim 10 or 11 , further comprising an input interface unit that accepts the setting of necessity regarding the standard sample measurement. The automatic analyzer according to any one of claims 1 to 12 , wherein the first time is the start time of the automatic analyzer. The automatic analyzer according to any one of claims 1 to 12 , wherein the first time is the completion time of the standard sample measurement determined to be necessary. It is a method of setting the start time of the automatic analyzer executed by the automatic analyzer.
When the automatic analyzer is shut down, it is necessary to determine the necessity of performing standard sample measurement using a standard sample for at least some of the inspection items that can be measured by the automatic analyzer. The process and
Based on the time required for the standard sample measurement, the standard sample measurement determined to be required to be performed is completed by the first time specified for activating the automated analyzer. A method for setting a start-up time of an automatic analyzer, which comprises a start-up time setting process for setting a second time representing a start-up time when the automatic analyzer is actually started. Measurement necessity determination unit that determines the necessity of performing standard sample measurement using a standard sample for at least some of the inspection items that can be measured by the automatic analyzer when the automatic analyzer is shut down. Based on the time required for the standard sample measurement so that the standard sample measurement determined to be necessary to be performed is completed by the first time specified for starting the automatic analyzer. It is a method of performing a measurement using a standard sample executed by an automatic analyzer including a start time setting unit for setting a second time indicating the start time when the automatic analyzer is actually started.
A system control process for starting the automatic analyzer at the set second time, and
A method for carrying out a measurement using a standard sample, comprising a standard sample measurement process for carrying out the measurement using the standard sample so as to be completed by the set first time.