JP6859134B2 - Fluid monitoring system - Google Patents

Description

The present invention relates to a quality evaluation technique, particularly to a fluid monitoring system.

For liquids such as purified water, pharmaceutical water, and water for injection, treatment standard values for microorganisms are set by the Pharmacopoeia. These liquids are produced, for example, by using a distillation method, an ultrafiltration method, a reverse osmosis membrane method, or the like (see, for example, Patent Documents 1 to 5). During production, these liquids are monitored for conductivity and total organic carbon (TOC) content to control quality. For pharmaceutical water, especially water for injection, a strict control standard value of 10 CFU / 100 mL or less for the generation of microorganisms is set. CFU (Colony Forming Unit) is a unit of the number of colonies formed by microorganisms on a medium. Even in purified water for pharmaceutical use, the permissible amount of microorganisms generated is 100 CFU / 100 mL or less, which is a stricter control standard value than drinking water. If it is suspected that the liquid has been contaminated with microorganisms, the liquid samples collected over time are concentrated, and the microorganisms contained in the liquid are analyzed and identified to determine the cause of the contamination. (See, for example, Patent Documents 6 to 9).

Japanese Patent No. 2997099 International Publication No. 2008/038575 Japanese Unexamined Patent Publication No. 2012-192315 Japanese Unexamined Patent Publication No. 2003-260463 Japanese Unexamined Patent Publication No. 2014-135935 Japanese Unexamined Patent Publication No. 2008-224271 Japanese Unexamined Patent Publication No. 2001-228604 Japanese Patent No. 3137396 Japanese Unexamined Patent Publication No. 2009-180594

Liquid samples that have been collected over time may also contain large amounts of liquid when no microbial contamination has occurred. Therefore, the liquid sample collected over time may have a low microbial concentration, and it is necessary to concentrate at a high magnification for the analysis and identification of the microorganism. However, concentration of a fluid such as a liquid is time-consuming and time-consuming. Therefore, one of the objects of the present invention is to provide a fluid monitoring system capable of efficiently collecting a fluid when microbial contamination occurs.

According to the aspect of the present invention, a microorganism detection device that detects microorganisms contained in the test fluid, a collection unit that collects the test fluid when the microorganism detection device detects microorganisms equal to or higher than the standard, and microorganisms. The first flow path connected to the detection device, the second flow path connected to the first flow path, the abandoned flow path connected to the first flow path, and the killing of microorganisms connected to the first flow path. When the test fluid is flowed from the upstream of the second flow path, the test fluid is guided to the microorganism detection device via the first flow path and heated from the upstream of the second flow path. When the fluid is flowed, the heated fluid is guided to the waste channel, and when the microbial killing fluid is flowed from the upstream of the microbial killing channel, the microbial killing fluid is passed through the first channel. A fluid monitoring system guided by a microbe detector is provided.

In the above fluid monitoring system, the portion where the second flow path is connected to the first flow path is closer to the microorganism detection device than the part where the microorganism killing flow path is connected to the first flow path, and the waste flow The portion where the path is connected to the first flow path may be farther from the microorganism detection device than the portion where the second flow path is connected to the first flow path.

In the above fluid monitoring system, the portion where the second flow path is connected to the first flow path is farther from the microorganism detection device than the part where the microorganism killing flow path is connected to the first flow path, and the waste flow The portion where the path is connected to the first flow path may be farther from the microorganism detection device than the portion where the microorganism killing flow path is connected to the first flow path.

In the above fluid monitoring system, at least the part where the second flow path is connected and the part where the flow path for killing microorganisms is connected are killed for the flow path by treating the first flow path for killing microorganisms. It may be further equipped with an extinguishing device.

The above-mentioned fluid monitoring system may further include a collection unit killing device for treating the collection unit with microorganisms.

In the above-mentioned fluid monitoring system, an inspected fluid flow path through which the fluid flows via the microorganism detection device may be further provided, and a collecting portion may be provided in the inspected fluid flow path.

The above-mentioned fluid monitoring system may further include a collection unit killing device for treating the collection unit and the inspected fluid flow path with microorganisms.

In the above fluid monitoring system, the collection unit may include a collection branch valve provided in the inspected fluid flow path.

In the above fluid monitoring system, the collection unit may further include a collection container connected to a collection branch valve.

In the above fluid monitoring system, when the microorganism detection device detects microorganisms equal to or higher than the standard, the collection branch valve may guide the fluid flowing through the inspected fluid flow path to the collection container.

According to the present invention, it is possible to provide a fluid monitoring system capable of efficiently collecting a fluid when microbial contamination occurs.

It is a schematic diagram of the fluid monitoring system which concerns on 1st Embodiment. It is a graph which shows the fluorescence intensity for each type of microorganism which concerns on 1st Embodiment. It is a graph which shows typically the relationship between the particle size of the microorganism in the fluid which concerns on 1st Embodiment, and the fluorescence intensity. It is a schematic diagram of the fluid monitoring system which concerns on 2nd Embodiment.

An embodiment of the present invention will be described below. In the description of the drawings below, the same or similar parts are represented by the same or similar reference numerals. However, the drawings are schematic. Therefore, the specific dimensions and the like should be determined in light of the following explanations. In addition, it goes without saying that the drawings include parts having different dimensional relationships and ratios from each other.

(First Embodiment)
As shown in FIG. 1, the fluid monitoring system according to the first embodiment has a microorganism detection device 20 that detects microorganisms contained in a test fluid that is a gas or a liquid, and a microorganism detection device 20 that detects microorganisms that exceed a standard. In this case, one or a plurality of collecting portions 30 for collecting the test fluid, a first flow path 101 connected to the microorganism detection device 20, and a second flow path 102 connected to the first flow path 101. And a waste flow path 103 connected to the first flow path 101, and a microorganism killing flow path 104 connected to the first flow path 101.

In the fluid monitoring system according to the first embodiment, when the test fluid is flowed from the upstream of the second flow path 102, the test fluid is guided to the microorganism detection device 20 via the first flow path 101. When the heating fluid is flowed from the upstream of the second flow path 102, the heating fluid is guided to the waste flow path 103. When the microorganism killing fluid is flowed from the upstream of the microorganism killing flow path 104, the microorganism killing fluid is guided to the microorganism detection device 20 via the first flow path 101.

For example, the portion where the second flow path 102 is connected to the first flow path 101 is closer to the microorganism detection device 20 than the portion where the microorganism killing flow path 104 is connected to the first flow path 101. Further, the portion where the waste flow path 103 is connected to the first flow path 101 is farther from the microorganism detection device 20 than the portion where the second flow path 102 is connected to the first flow path 101.

In the fluid monitoring system according to the first embodiment, the first branch valve 41 provided at the portion where the second flow path 102 is connected to the first flow path 101 and the microorganism killing flow path 104 are the first flow paths. A second branch valve 42 provided at a portion connected to the 101 is further provided.

For example, a plant 50 is connected upstream of the second flow path 102. The fluid to be inspected by the microorganism detection device 20 flows from the plant 50 via the second flow path 102, the first branch valve 41, and the first flow path 101. The test fluid to be inspected by the microorganism detection device 20 is, for example, a liquid such as purified water, pharmaceutical water, and injection water during or after production, but is not limited thereto. An inspected fluid flow path 105 through which a fluid flows through the microorganism detection device 20 is connected to the downstream side of the microorganism detection device 20. The collecting unit 30 is provided in the inspected fluid flow path 105. A collection flow path 2 is connected to the inspected fluid flow path 105 via a collection branch valve 3. The collection branch valve 3 guides the fluid flowing through the inspected fluid flow path 105 to the collection flow path 2 according to the control.

A collection container 5 for collecting the fluid guided to the collection flow path 2 is aseptically connected to the end of the collection flow path 2. As the collection container 5, for example, a sterile bag, a single-use bag, and a heatable closed container can be used, but the collection container 5 is not limited thereto. The collection branch valve 3, the collection flow path 2, and the collection container 5 form at least a part of the collection unit 30.

As the microorganism detection device 20 capable of detecting microorganisms in real time, the device disclosed in US Pat. No. 7430046 can be used, but the device is not limited thereto. For example, the microorganism detection device 20 irradiates the test fluid with light, detects the fluorescence emitted by the microorganisms contained in the test fluid, and detects the microorganisms contained in the test fluid.

For example, the microorganism detection device 20 includes a light source such as a laser. The light source irradiates a fluid with light such as a laser beam. The light may be visible light or ultraviolet light. When the light is visible light, the wavelength of the light is, for example, in the range of 400 to 550 nm, for example 405 nm. When the light is ultraviolet light, the wavelength of the light is, for example, in the range of 310 to 380 nm, for example 340 nm. Further, the microorganism detection device 20 may include an optical system that connects the irradiation light to the focal point, and a pipe, a nozzle, or the like that allows the fluid to pass through the focal point.

Here, when the fluid contains microorganisms containing bacteria, nicotinamide adenine dinucleotide, riboflavin and the like contained in the microorganisms irradiated with light fluoresce. Further, when the fluid contains particles containing microorganisms and non-living organisms, the light that hits the particles is scattered by Mie scattering, and scattered light is generated.

Examples of bacteria include Gram-negative bacteria, Gram-positive bacteria, and fungi, including mold spores. Examples of Gram-negative bacteria include Escherichia coli. Examples of Gram-positive bacteria include Staphylococcus epidermidis, Bacillus subtilis spores, Micrococcus, and Corynebacterium. Aspergillus is an example of a fungus containing mold spores. However, the microorganisms detected by the microorganism detection device 20 are not limited to these.

The microorganism detection device 20 further includes a fluorescence detector and a scattered light detector. The fluorescence detector detects the fluorescence emitted by the microorganism and measures the fluorescence intensity. From the number of times the fluorescence detector detects fluorescence, it is possible to measure the number of microorganisms contained in the fluid. Further, as shown in FIG. 2, the intensity of fluorescence emitted by a microorganism differs depending on the type of microorganism. Therefore, it is possible to identify the type of microorganism contained in the fluid from the intensity of fluorescence detected by the fluorescence detector of the microorganism detection device 20 shown in FIG.

The scattered photodetector detects the light scattered by the particles contained in the fluid. It is possible to measure the number of particles from the number of times the scattered light detector detects scattered light. In addition, the intensity of scattered light by the particles correlates with the particle size of the particles. Therefore, it is possible to determine the particle size of the particles contained in the fluid by detecting the intensity of the scattered light with a scattered light detector. In addition, the particle size of microorganisms differs depending on the type of microorganism. Therefore, it is possible to identify the type of microorganism contained in the fluid from the intensity of the scattered light detected by the scattered light detector.

When the scattered light detector detects the scattered light and the fluorescence detector does not detect the fluorescence, it is known that the particles contained in the fluid are abiotic particles. When the scattered light detector detects the scattered light and the fluorescence detector detects the fluorescence, it is known that the fluid contains microorganisms. Here, the non-biological particles include harmless or harmful chemical substances, dust, dust, dust and the like.

The microorganism detection device 20 identifies the type of microorganism contained in the fluid by using at least one of the detected fluorescence intensity and the particle size based on the scattered light intensity. Methods of identifying the type of microorganism based on both fluorescence intensity and scattered light intensity are disclosed in US Pat. No. 6,85440 and US Pat. No. 7,106,442. For example, as shown in FIG. 3, there is a correlation between the particle size and the fluorescence intensity depending on the type of microorganism. Therefore, it is possible to specify the type of microorganism from the fluorescence intensity and the particle size by acquiring the graph as shown in FIG. 3 in advance.

Further, the microorganism detection device 20 shown in FIG. 1 identifies the number of microorganisms contained in a predetermined volume of fluid by using at least one of the number of times fluorescence is detected and the number of times scattered light is detected. The flow rate of the fluid flowing through the first flow path 101 can be measured by a flow meter. The microorganism detection device 20 may specify the concentration of microorganisms in the fluid as the number of microorganisms contained in the fluid having a predetermined volume.

A central processing unit (CPU) 300 is connected to the microorganism detection device 20. The microorganism detection device 20 transmits the type of the specified microorganism and the number of microorganisms contained in the fluid of a predetermined volume to the CPU 300 in real time. When the number of microorganisms could be specified but the type of microorganism could not be specified, the microorganism detection device 20 received a signal indicating that the type of microorganism could not be specified, and the microorganism contained in the fluid having a predetermined volume. Is transmitted to the CPU 300.

A reference storage device 351 is connected to the CPU 300. The reference storage device 351 stores the number of microorganisms, which is a reference value for determining that microbial contamination has occurred in the fluid. The reference value is appropriately set with reference to, for example, the reference value of microbial contamination described in the Pharmacopoeia. The reference value may be the instantaneous concentration of microorganisms or the integrated concentration of microorganisms in a certain period of time. The CPU 300 includes a comparison unit 301. The comparison unit 301 compares the number of detected microorganisms detected by the microorganism detection device with the reference value stored in the reference storage device 351.

When the number of microorganisms detected by the microorganism detection device 20 is equal to or greater than the reference value, the comparison unit 301 may determine that the fluid flowing through the first flow path 101 has been contaminated with microorganisms. Further, when the number of detected microorganisms detected by the microorganism detection device 20 is less than the reference value, the comparison unit 301 determines that the fluid flowing through the first flow path 101 is not contaminated with microorganisms.

The CPU 300 further includes a control unit 302. When the number of detected microorganisms detected by the microorganism detection device 20 is equal to or greater than the reference value, the control unit 302 controls the collection branch valve 3 to collect the fluid flowing through the inspected fluid flow path 105. Guide to the road 2 and collect the fluid in the collection container 5.

As the collection branch valve 3, a two-way valve, a three-way valve, a combination thereof, or the like can be used. Examples of the valve driving method include electric driving and air driving. Types of valves include gate valves, glove valves, check valves, hole valves, butterfly valves, lambda valves and the like.

The collection flow path 2 may be provided with a flow meter for measuring the amount of fluid collected in the collection container 5. The amount of fluid collected in the collection container 5 is appropriately set depending on the type of fluid. For example, when the fluid is purified water, it is collected in units of 1 mL, and when the fluid is water for injection, it is collected in units of 100 mL, but the present invention is not limited thereto. When the amount of collected fluid reaches a specified amount, a warning may be issued from the output device 322 connected to the CPU 300.

When the microorganism detection device 20 detects a microorganism a plurality of times, the control unit 302 sequentially controls the collection branch valve 3 connected to the empty collection container 5 to sequentially control the fluid flowing through the inspected fluid flow path 105. To the empty collection container 5. As a result, when the microorganism detection device 20 detects the microorganism a plurality of times, it is possible to collect the test fluid at each time. The control unit 302 switches the collection branch valve 3 according to the volume of the flow path between the microorganism detection device 20 and the individual collection branch valves 3 and the flow velocity of the fluid flowing therethrough. The timing may be adjusted.

The fluid monitoring system according to the first embodiment may further include an incubator for culturing microorganisms in the fluid collected by the collecting unit 30. For example, by inoculating a medium with at least a part of the liquid collected in the collection container 5, or collecting bacteria using a filtration filter such as a membrane filter, and culturing the microorganisms, the genus and species of the microorganisms. It is possible to verify such types by visual inspection, an optical microscope, a fluorescence microscope, or the like. In addition, the genus, species, and the like of the microorganism may be identified by analyzing the gene sequence of the microorganism grown in the culture.

An input device 321 is connected to the CPU 300. A keyboard, mouse, or the like can be used as the input device 321. The input device 321 is used, for example, when storing a reference value in the reference storage device 351. Further, a display, a speaker, or the like can be used for the output device 322. The output device 322 outputs, for example, the comparison result of the comparison unit 301.

Further, the comparison unit 301 and the control unit 302 include the time when the collection unit 30 starts collecting the fluid, the time when the collection of the fluid ends, the temperature of the fluid, the pressure of the fluid, and the biological particles in the microorganism detection device 20. And the detection history of non-biological particles, the total number of detected biological particles and non-biological particles, the scatter diagram of the detected fluorescence and scattered light intensity, etc. are recorded in association with the identifier of the collection container 5, and recorded in the output device 322. It may be output.

According to the fluid monitoring system according to the first embodiment, the fluid can be collected in the collection container 5 only when the microorganism is detected in the fluid. Therefore, it is possible to efficiently analyze the fluid in which microbial contamination has occurred. For example, the collected microorganisms in the fluid may be subjected to fluorescence microscopy analysis, gene analysis and the like. This makes it possible to identify the type of microorganism in the fluid with higher accuracy, and it may be possible to identify the source of the microorganism.

Conventionally, when microbial contamination of a fluid is discovered, it is not known when the microbial contamination has occurred, so a large amount of fluid is concentrated to analyze the microorganisms. On the other hand, according to the fluid monitoring system according to the first embodiment, when microbial contamination of the fluid is discovered, it is possible to immediately collect the fluid in which the microbial contamination has occurred. Since the concentration of microorganisms in the collected fluid in which microbial contamination has occurred is high, it is possible to analyze the microorganisms by omitting the step of concentrating.

Here, in the fluid monitoring system according to the first embodiment, if at least one of the first flow path 101, the second flow path 102, and the inside of the microorganism detection device 20 is contaminated with microorganisms or the like, the plant 50 Even if the test fluid flowing from is not contaminated with microorganisms, it is possible to make a false judgment that the test fluid is contaminated with microorganisms. Further, if at least one of the first flow path 101, the second flow path 102, the inside of the microorganism detection device 20, and the inspected fluid flow path 105 and the like is contaminated with microorganisms and the like, the subject flowing from the plant 50. There is a possibility that the collecting unit 30 collects microorganisms and the like that are not contained in the test fluid.

Therefore, it is necessary to kill microorganisms that may exist in the first flow path 101, the second flow path 102, the inside of the microorganism detection device 20, the inspected fluid flow path 105, and the like.

Here, when a heating fluid for killing microorganisms is flowed from the plant 50 upstream of the second flow path 102, the control unit 302 controls the first branch valve 41 and the second branch valve 42. , The heating fluid is guided to the waste flow path 103. For example, by flowing a large flow rate of heating fluid from the second flow path 102 to the waste flow path 103 via the first branch valve 41 and the second branch valve 42, the second flow path 102 and the first branch valve 41 Microorganisms that may be present in the valve are killed. Further, for example, when the heat resistance of the microorganism detection device 20 is low, the heating fluid is suppressed from flowing in the microorganism detection device 20. Here, the heating fluid may be a liquid or a gas such as steam. For example, the diameter of the waste flow path 103 is the same as, but is not limited to, the diameter of the second flow path 102.

For example, a microbial killing fluid storage unit 51 for storing a microbial killing fluid is connected to the upstream of the microbial killing flow path 104. The microbial killing fluid contains, for example, a peracetic acid-based disinfectant, a hydrogen peroxide solution, a chemical such as hypochlorous acid, ozone, or the like. The microbial killing fluid may be a liquid or a gas. When the microbial killing fluid is flowed from the microbial killing fluid storage unit 51 to the microbial killing flow path 104, the control unit 302 controls the first branch valve 41 and the second branch valve 42 to control the microorganisms. The killing fluid is guided to the first flow path 101, the microorganism detection device 20, and the inspected fluid flow path 105. As a result, microorganisms that may exist in the first branch valve 41, the first flow path 101 downstream of the first branch valve 41, the microorganism detection device 20, the inspected fluid flow path 105, and the collection branch valve 3 are killed. Will be done. It is preferable that the control unit 302 controls the collection branch valve 3 so that the microbial killing fluid does not flow into the collection flow path 2 and the collection container 5.

The fluid monitoring system may further include a collection unit killing device 60 that heats the collection unit 30. The collection unit killing device 60 heats at least the collection flow path 2 and the collection container 5 from the outside. As a result, microorganisms that may be present in the collection channel 2 and the collection container 5 are killed. The collecting unit killing device 60 may also heat the inspected fluid flow path 105 and the collecting branch valve 3 from the outside. The killing device 60 for the collector may heat the subject with hot water or steam. Alternatively, the collection unit killing device 60 may electrically heat the subject. When the inspected fluid flow path 105 and the collection unit 30 and the like are made of a transparent member, the collection unit killing device 60 irradiates the inspected fluid flow path 105 and the collection unit 30 and the like with ultraviolet rays (UV). Then, the microorganism may be killed.

After killing microorganisms with the heating fluid, killing microorganisms with the fluid for killing microorganisms, and killing microorganisms with the killing device 60 for the collecting part, does the test fluid contain microorganisms? By inspecting whether or not it is present with the microorganism detection device 20, it is possible to suppress the detection or collection of microorganisms that were not originally contained in the test fluid in the upstream plant 50.

(Second Embodiment)
In the fluid monitoring system according to the second embodiment shown in FIG. 4, the portion where the second flow path 102 is connected to the first flow path 101 and the microorganism killing flow path 104 are connected to the first flow path 101. It is farther from the microorganism detection device 20 than the part. Further, the portion where the waste flow path 103 is connected to the first flow path 101 is farther from the microorganism detection device 20 than the portion where the microorganism killing flow path 104 is connected to the first flow path 101.

In the fluid monitoring system according to the second embodiment, when the test fluid is flowed from the upstream of the second flow path 102, the test fluid is guided to the microorganism detection device 20 via the first flow path 101. When the heating fluid is flowed from the upstream of the second flow path 102, the heating fluid is guided to the waste flow path 103. When the microorganism killing fluid is flowed from the upstream of the microorganism killing flow path 104, the microorganism killing fluid is guided to the microorganism detection device 20 via the first flow path 101.

Specifically, when a heating fluid for killing microorganisms is flowed from the plant 50 upstream of the second flow path 102, the control unit 302 controls the first branch valve 41 to supply the heating fluid. , Leads to the abandoned flow path 103. For example, by flowing a large flow rate of a heating fluid from the second flow path 102 to the waste flow path 103 via the first branch valve 41, microorganisms that may exist in the second flow path 102 and the first branch valve 41 can be present. Be killed.

When the microbial killing fluid is flowed from the microbial killing fluid storage unit 51 to the microbial killing flow path 104, the control unit 302 controls the second branch valve 42 to use the microbial killing fluid. It leads to the first flow path 101, the microorganism detection device 20, and the inspected fluid flow path 105. As a result, microorganisms that may be present in the second branch valve 42, the first flow path 101 downstream of the second branch valve 42, the microorganism detection device 20, the inspected fluid flow path 105, and the collection branch valve 3 are killed. Will be done.

The fluid monitoring system according to the second embodiment microbially kills at least the first flow path 101 between the portion to which the second flow path 102 is connected and the portion to which the microbial killing flow path 104 is connected. A flow path killing device 40 for killing may be further provided.

The flow path killing device 40 heats at least the first flow path 101 between the first branch valve 41 and the second branch valve 42 from the outside, where the heating fluid and the microorganism killing fluid do not flow. As a result, microorganisms that may exist in the first flow path 101 between the first branch valve 41 and the second branch valve 42 are killed. In the flow path killing device 40, the first branch valve 41 and the second branch valve 42 may also be heated from the outside. The channel killing device 40 may use hot water or steam to heat the subject. Alternatively, the flow path killing device 40 may electrically heat the subject.

Alternatively, when the first flow path 101 is transparent, the flow path killing device 40 may irradiate the first flow path 101 or the like with ultraviolet rays (UV) to kill microorganisms.

Killing microorganisms with a heating fluid, killing microorganisms with a fluid for killing microorganisms, killing microorganisms with a channel killing device 40, killing microorganisms with a collecting part killing device 60, May be performed simultaneously or separately. Killing microorganisms with a heating fluid, killing microorganisms with a fluid for killing microorganisms, killing microorganisms with a channel killing device 40, killing microorganisms with a collecting part killing device 60, By inspecting whether or not the test fluid contains microorganisms with the microorganism detection device 20, the upstream plant 50 detects or collects microorganisms that were not originally contained in the test fluid. It is suppressed.

(Other embodiments)
Although the invention has been described in embodiments as described above, the descriptions and drawings that form part of this disclosure should not be understood to limit the invention. This disclosure should reveal to those skilled in the art various alternative embodiments, examples and operational techniques. For example, the microorganism detection device 20 shown in FIG. 1 may detect microorganisms in a fluid based on the conductivity and absorbance of the fluid. As described above, it should be understood that the present invention includes various embodiments and the like.

3 ... Branch valve for collection, 5 ... Collection container, 20 ... Microorganism detection device, 30 ... Collection part, 40 ... Channel killing device, 41, 42 ... -Branch valve, 50 ... plant, 51 ... fluid storage unit for killing, 51 ... fluid storage unit for killing microorganisms, 60 ... killing device for collection unit, 101 ... 1 flow path, 102 ... 2nd flow path, 103 ... waste flow path, 104 ... microorganism killing flow path, 105 ... inspected fluid flow path, 300 ... central arithmetic processing device , 301 ... Comparison unit, 302 ... Control unit, 321 ... Input device, 322 ... Output device, 351 ... Reference storage device

Claims (10)

A microorganism detection device that detects microorganisms contained in the test fluid,
When the microorganism detection device detects microorganisms above the standard, a collection unit that collects the test fluid and a collection unit.
The first flow path connected to the microorganism detection device and
The second flow path connected to the first flow path and
The abandoned flow path connected to the first flow path and
A flow path for killing microorganisms connected to the first flow path,
With
When the test fluid is flowed from the upstream of the second flow path, the test fluid is guided to the microorganism detection device via the first flow path.
When the heating fluid is flowed from the upstream of the second flow path, the heating fluid is guided to the waste flow path.
When the microorganism killing fluid is flowed from the upstream of the microorganism killing flow path, the microorganism killing fluid is guided to the microorganism detection device through the first flow path.
Fluid monitoring system. A microorganism detection device that detects microorganisms contained in the test fluid, and
When the microorganism detection device detects microorganisms above the standard, a collection unit that collects the test fluid and a collection unit.
The first flow path connected to the microorganism detection device and
The second flow path connected to the first flow path and
The abandoned flow path connected to the first flow path and
A flow path for killing microorganisms connected to the first flow path,
With
When the test fluid is flowed from the upstream of the second flow path, the test fluid is guided to the microorganism detection device via the first flow path.
When the heating fluid is flowed from the upstream of the second flow path, the heating fluid is guided to the waste flow path, and the heating fluid is guided to the waste flow path.
When the microorganism killing fluid is flowed from the upstream of the microorganism killing flow path, the microorganism killing fluid is guided to the microorganism detection device through the first flow path.
The portion where the second flow path is connected to the first flow path is closer to the microorganism detection device than the portion where the microorganism killing flow path is connected to the first flow path.
The portion where the waste channel is connected to the first channel is farther from the microorganism detection device than the portion where the second channel is connected to the first channel.
Fluid monitoring system. A microorganism detection device that detects microorganisms contained in the test fluid, and
When the microorganism detection device detects microorganisms above the standard, a collection unit that collects the test fluid and a collection unit.
The first flow path connected to the microorganism detection device and
The second flow path connected to the first flow path and
The abandoned flow path connected to the first flow path and
A flow path for killing microorganisms connected to the first flow path,
With
When the test fluid is flowed from the upstream of the second flow path, the test fluid is guided to the microorganism detection device via the first flow path.
When the heating fluid is flowed from the upstream of the second flow path, the heating fluid is guided to the waste flow path, and the heating fluid is guided to the waste flow path.
When the microorganism killing fluid is flowed from the upstream of the microorganism killing flow path, the microorganism killing fluid is guided to the microorganism detection device through the first flow path.
At least, a flow path killing device for treating the first flow path between the portion to which the second flow path is connected and the portion to which the microorganism killing flow path is connected is further provided. Prepare, prepare
Fluid monitoring system. The portion where the second flow path is connected to the first flow path is farther from the microorganism detection device than the portion where the microorganism killing flow path is connected to the first flow path.
The portion where the waste channel is connected to the first channel is farther from the microorganism detection device than the portion where the microorganism killing channel is connected to the first channel.
The fluid monitoring system according to claim 1 or 3. The fluid monitoring system according to any one of claims 1 to 4, further comprising a collecting device killing device for killing microorganisms in the collecting section. Further provided with an inspected fluid flow path through which the fluid flows via the microorganism detection device is provided.
The fluid monitoring system according to any one of claims 1 to 4, wherein the collecting unit is provided in the inspected fluid flow path. The fluid monitoring system according to claim 6, further comprising a collecting unit killing device for killing microorganisms in the collecting unit and the inspected fluid flow path. The fluid monitoring system according to claim 6 or 7, wherein the collecting unit includes a collecting branch valve provided in the inspected fluid flow path. The fluid monitoring system according to claim 8, wherein the collecting unit further includes a collecting container connected to the collecting branch valve. The fluid monitoring system according to claim 9, wherein when the microorganism detection device detects microorganisms equal to or higher than a reference, the collection branch valve guides the fluid flowing through the inspected fluid flow path to the collection container.

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