JP6900002B2 - Liquid crystal mixed crystal emulsified composition, liquid crystal emulsified cosmetic, liquid crystal mixed crystal emulsified composition manufacturing method and liquid crystal emulsified cosmetic manufacturing method - Google Patents

Description

The present invention relates to a liquid crystal mixed crystal emulsified composition, a liquid crystal emulsified cosmetic, a method for producing a liquid crystal mixed crystal emulsified composition, and a method for producing a liquid crystal emulsified cosmetic. The present invention relates to a liquid crystal mixed crystal emulsified composition having good properties, a liquid crystal emulsified cosmetic, a method for producing a liquid crystal mixed crystal emulsified composition, and a method for producing a liquid crystal emulsified cosmetic.

Conventionally, in the field of cosmetics and the like, various methods have been proposed for liquid crystal emulsified compositions. For example, in Patent Document 1, at least one selected from ceramide, glucosyl ceramide, and galactosyl ceramide, cholesterol and fatty acid are heated in an oil agent to a temperature equal to or higher than the phase transition temperature of a mixed system of ceramides and fatty acids. A method for producing a liquid crystal emulsion obtained by adding a water-soluble polyhydric alcohol, mixing the obtained composition with an aqueous medium having the same phase transition temperature or higher with stirring, and cooling to a phase transition temperature or lower is disclosed. Patent Document 2 discloses a complex having a liquid crystal structure of an amphoteric surfactant and / or a semipolar surfactant, a higher fatty acid, and water.

Further, Patent Document 3 describes one or more selected from ceramide and ceramide-like structural substances, one or more selected from alkyl polyglucosides, and one or more selected from alcohols and polyols. Disclosed, Patent Document 4 discloses a higher alcohol, a fatty acid in an amount of 0.1 to 0.8 times the weight of the higher alcohol, a lipophilic nonionic surfactant, and a hydrophilic nonionic interface. A liquid crystal type external base composed of an activator, a polyhydric alcohol and water is disclosed, and Patent Document 5 comprises an oil component, a higher alcohol, a higher fatty acid, a nonionic surfactant, a water-soluble polyhydric alcohol and water, and is a lamellar. A liquid crystal type emulsifying composition for blending a drug having a structure (layered structure) and having excellent drug stability, drug release, water retention, temperature stability, and usability is disclosed.

Further, Non-Patent Documents 1 to 3 disclose that the lamellar structure (layered structure) of a liquid crystal emulsion changes when the hydrocarbon / surfactant ratio is increased in a water / oil microemulsion system. 4 to 5 disclose that the oil / water microemulsion is an extension of the aqueous micelle solution, and Non-Patent Document 6 discloses the stabilization of the emulsion by combining an ionic surfactant and a medium-chain alcohol. Is disclosed.

"Rev. Sci. Instrument, 50, 698 (1979)" "J. Colloid Interface Sci., 75, 276 (1980)" "J. Phys. Chem, 84, 3633 (1980)" "J. Dispersion, Sci. Technology, 1,341 (1980)" "Pure Appl. Chem., 52, 1349 (1980)" "Microemulsion: Theoryand Practice, Acadimie, New York (1967)"

Japanese Unexamined Patent Publication No. 09-124432 Japanese Unexamined Patent Publication No. 08-217633 Japanese Unexamined Patent Publication No. 09-157149 Japanese Patent Application Laid-Open No. 63-287718 Japanese Unexamined Patent Publication No. 2003-212716

However, the techniques of Patent Documents 1 to 3 relate to a method for producing a liquid crystal emulsion using lecithin, ceramide, and glucosylceramide and a liquid crystal emulsion, and research on a liquid crystal emulsion using a nonionic surfactant is sufficient. Not done. Therefore, there is a problem that the liquid crystal emulsified composition or the like has a bad feel, is particularly heavy in elongation, and has poor skin compatibility.

Further, the technique of Patent Document 4 uses a lipophilic emulsifier, but since the liquid crystal has a low hydrophobic binding force, the liquid crystal is destroyed by dilution with water or the like to become white emulsified particles, and the stability of the liquid crystal is poor. There is a problem that liquid crystal is not formed unless a manton gaulin emulsifier is used, and further, the technique of Patent Document 5 has improved drug stability, drug release, water retention, temperature stability, and usability. Although it was excellent, there was room for improvement in the feel of the liquid crystal emulsified composition and the like, especially in terms of elongation and familiarity with the skin.

Furthermore, although proposals have been made for liquid crystal emulsions using nonionic surfactants, nonionic surfactants are limited to unsaturated fatty acids or branched fatty acid diglycerin and / or triglycerin monoester compounds. There was room for improvement in the feel of the liquid crystal emulsified composition, especially in terms of elongation and familiarity with the skin.

Further, in the techniques of Non-Patent Documents 1 to 3, it is known that the lamellar structure (layered structure) of a liquid crystal emulsion changes when the hydrocarbon / surfactant ratio is increased in a water / oil microemulsion system. , There is a problem in terms of temperature stability, and in the techniques of Non-Patent Documents 4 to 5, it is known that an oil / water microemulsion is formed on an extension of a micelle aqueous solution, but the exact structure has not been clarified. The technique of Non-Patent Document 6 can stabilize an emulsion by combining an ionic surfactant and a medium-chain alcohol, but has a problem with the skin irritation of the alcohol and has not been put into practical use. None of these techniques can sufficiently improve the feel of the liquid crystal emulsified composition, especially the elongation and the familiarity with the skin.

Therefore, an object of the present invention is to solve the above-mentioned problems of the prior art, and to provide a liquid crystal mixed crystal emulsified composition, a liquid crystal emulsified cosmetic, and a liquid crystal mixed crystal type, which are light in elongation, have good skin compatibility, and have good stability. It is an object of the present invention to provide a method for producing an emulsified composition and a method for producing a liquid crystal emulsified cosmetic.

As a result of diligent studies to solve the above problems, the present inventors can achieve the above object by combining a lamellar type liquid crystal emulsifying composition and a component exhibiting maltese cloth when observed with a polarizing microscope. This has led to the completion of the present invention.

That is, the liquid crystal mixed crystal emulsified composition of the present invention comprises (A) oil, (B) higher alcohol, (C) higher fatty acid soap, (D) nonionic surfactant, (E) water-soluble polyhydric alcohol and It is characterized in that (F) a layered liquid crystal emulsified composition having water is added with a component exhibiting (G) a maltese cloth when observed with a polarizing microscope.

Further, in the liquid crystal mixed crystal emulsified composition of the present invention, the blending amount of the (A) oil content in the liquid crystal mixed crystal emulsified composition is 0.5 to 40% by mass, and the (B) higher alcohol and the above. The total amount of the (C) higher fatty acid soap and the (D) nonionic surfactant is preferably 0.5 to 25% by mass.

Further, in the liquid crystal mixed crystal emulsified composition of the present invention, it is preferable that the component exhibiting martese cloth when observed with the (G) polarizing microscope is an alkyl glucoside or a lecithin derivative.

In the liquid crystal emulsified cosmetic of the present invention, the liquid crystal mixed crystal emulsified composition, (H) water, and (I) ethanol in which the components exhibiting maltese cloth when observed with the (G) polarizing microscope are lecithin derivatives. It is characterized in that it is diluted with and / or a water-soluble polyhydric alcohol. Further, it is preferable that the liquid crystal type emulsified cosmetic is one selected from the group consisting of lotions, emulsions and gel-like cosmetics.

The method for producing the liquid crystal mixed crystal emulsified composition of the present invention is (A) oil, (B) higher alcohol, (C) higher fatty acid soap, (D) nonionic surfactant, (E) water-soluble polyhydric alcohol. And (F) water is heated and mixed to prepare a layered liquid crystal emulsified composition, and (G) a component exhibiting a martase cloth when observed with a polarizing microscope is added to the layered liquid crystal emulsified composition. Is what you do.

Further, in the method for producing a liquid crystal mixed crystal emulsified composition of the present invention, the amount of the oil (A) blended in the liquid crystal mixed crystal emulsified composition is 0.5 to 40% by mass, and the (B) is described. The total amount of the higher alcohol, the (C) higher fatty acid soap, and the (D) nonionic surfactant is preferably 0.5 to 25% by mass.

Further, in the method for producing a liquid crystal mixed crystal emulsified composition of the present invention, it is preferable that the component exhibiting martese cloth when observed with the (G) polarizing microscope is an alkyl glucoside or a lecithin derivative.

In the method for producing a liquid crystal emulsified cosmetic of the present invention, a liquid crystal mixture produced by the method for producing a liquid crystal mixed crystal emulsified composition using a lecithin derivative as a component exhibiting a maltese cloth when observed with a (G) polarizing microscope. It is characterized in that (H) water and (I) ethanol and / or water-soluble polyhydric alcohol are diluted and added to the crystallized emulsified composition. Further, it is preferable that the liquid crystal type emulsified cosmetic is one selected from the group consisting of lotions, emulsions and gel-like cosmetics.

According to the present invention, a liquid crystal mixed crystal emulsified composition, a liquid crystal emulsified cosmetic, a method for producing a liquid crystal mixed crystal emulsified composition, and a liquid crystal emulsified cosmetic, which spread lightly, fit well on the skin, and have good stability. A method can be provided.

It is a figure which shows the polarization micrograph of Example 1. It is a figure which shows the polarization micrograph of Example 2. It is a figure which shows the polarization micrograph of the comparative example 1. FIG. It is a figure which shows the polarization micrograph of the 20% aqueous solution of phosphatidylcholine. It is a figure which shows 4 times the photograph of the polarizing microscope photograph of FIG.

Hereinafter, the present invention will be specifically described.
The liquid crystal mixed crystal emulsified composition of the present invention comprises (A) oil, (B) higher alcohol, (C) higher fatty acid soap, (D) nonionic surfactant, (E) water-soluble polyhydric alcohol and (F). ) It is characterized in that a component exhibiting a martase cloth when observed with a (G) polarizing microscope is added to a layered liquid crystal emulsified composition having water. The method for producing the liquid crystal mixed crystal emulsified composition of the present invention is (A) oil, (B) higher alcohol, (C) higher fatty acid soap, (D) nonionic surfactant, and (E) water-soluble poly. A layered liquid crystal emulsified composition is prepared by heating and mixing a hydrating alcohol and (F) water, and a component exhibiting a maltese cloth when observed with a (G) polarizing microscope is added to the layered liquid crystal emulsified composition. It is a feature. There are various liquid crystal structures, for example, a hexagonal structure, a lamellar structure, an inverted hexagonal structure, and a discontinuous structure in which a portion through which light passes and a portion through which light passes continuously alternate when viewed with a polarizing microscope. There are concentric lamellas and the like that exhibit a Maltese cross (Maltese cross). Among these, the emulsified composition of the liquid crystal structure having a lamellar structure in which the surfactant is continuous has excellent stability because the emulsifiers are continuously connected, but the elongation is heavy in terms of usability. There was a problem that it did not fit well on the skin. Therefore, in the present invention, the liquid crystal structure having a lamellar structure is broken by combining the liquid crystal structure having a lamellar structure with "a component exhibiting (G) martese cloth" that exists independently like emulsified particles. Instead, the "component exhibiting (G) martese cloth" is inserted between the liquid crystal structures having the lamellar structure to lighten the elongation of the emulsified composition and improve the familiarity with the skin. In the present invention, the "layered liquid crystal emulsification composition" is an emulsification composition that does not contain a component exhibiting maltese cloth when observed with the (G) polarizing microscope, and is referred to as a "liquid crystal mixed crystal emulsification composition". Is an emulsified composition containing a component exhibiting maltese cloth when observed with the (G) polarizing microscope. The method for producing the layered (lamellar) type liquid crystal emulsifying composition is not limited as long as the layered (lamellar) type liquid crystal emulsifying composition can be produced, and for example, the method described in JP-A-2003-212716 can be used.

Further, in the conventional technique described in Patent Document 5, since a surfactant with polyoxyethylene addition is used as a nonionic surfactant, a moist feeling may be felt, but a sticky feeling is felt and the skin is familiar to the skin. I feel bad. Furthermore, the use of polyoxyethylene-added surfactants tends to be avoided due to the recent increase in safety consciousness toward the environment and the human body. Therefore, decaglycerin fatty acid ester-based emulsifiers, which are highly safe for the environment and the human body, are used, but compared to surfactants with polyoxyethylene addition, it is difficult to form a liquid crystal structure and the feeling of use tends to be sticky. Become stronger. Therefore, by adding a component that exhibits a maltese cloth when observed with the (G) polarizing microscope, a stable liquid crystal mixed crystal emulsified composition or the like can be produced, and further, the feel during use becomes lighter and sticky. It is possible to have a good feel with less.

In the present invention, the component exhibiting a maltese cross when observed with a (G) polarizing microscope is not limited as long as it exhibits a maltese cross (Maltese cross) under a polarizing microscope, but for example, an alkyl glucoside. , Recitin derivatives and the like. By using a natural surfactant such as an alkyl glucoside or a lecithin derivative to eliminate the continuous layer of the emulsifier and producing a liquid crystal mixed crystal emulsified composition, the elongation is lightened, the usability is improved, and the stability is further improved. Is good, the water retention effect is high, the moisturizing effect is sustained, and the effect of improving the barrier function of the skin can be enhanced.

In the present invention, the polarizing microscope is a microscope capable of irradiating a sample with polarized light and observing polarized light and birefringence characteristics. For example, CX41 manufactured by Olympus Corporation can be used.

Examples of the alkyl glucoside include decyl glucoside, lauryl glucoside, myristyl glucoside, cocoyl glucoside, and the like. Specifically, MONTANOV 68 (trade name) and MONTANOV 202 (trade name) manufactured by Seiwa Kasei Co., Ltd. ), MONTANOV L (product name), MONTANOV 82 (product name), MONTANOV S (product name), MONTANOV 14 (product name), etc. Name), etc., My Doll 10 (product name) made by Kao Co., Ltd., My Doll 12 (product name), Planta Care 2000UP (product name) made by BASF, Planta Care 1200UP (product name), Planta Care 818UP (product name) Name), planter care series such as planter care 800UP (trade name), etc. can be mentioned.

In the present invention, the lecithin derivative contains, for example, phosphatidylcholine, monoacylphosphatidylcholine, phosphatidylethanolamine, phosphatidylglycerol, phosphatidylinositol, phosphatidylserine, hydrogenated lecithin, lecithin hydroxide, and the like, and is derived from soybean. , Egg yolk origin, etc., regardless of its origin. Specific examples of such lecithin derivatives include Basis LP-20 (trade name), Basis LP-20H (trade name), and Basis LS-60HR (trade name) manufactured by Nisshin Oillio Group Co., Ltd. Egg Lecithin PL-100M (trade name), Egg Lecithin PC-98N (trade name), Egg Lecithin PL-100P (trade name), etc. , PHOSPHOLIPON 75G (product name), PHOSPHOLIPON 50 (product name), PHOSPHOLIPON 20 (product name), PHOSPHOLIPON 90H (product name), PHOSPHOLIPON 80H (product name), etc. Name), NIKKOL lecithinol S-10EX (trade name), NIKKOL lecithinol SH 50 (trade name), NIKKOL lecithinol WS-50 (trade name), etc., Cyclic lysophosphalysate Na (trade name) manufactured by SANSHO Co., Ltd., etc. Can be mentioned.

In the liquid crystal emulsified cosmetic of the present invention, the liquid crystal mixed crystal emulsified composition, (H) water, and (I) ethanol in which the components exhibiting maltese cloth when observed with the (G) polarizing microscope are lecithin derivatives. It is characterized in that it is diluted with and / or a water-soluble polyhydric alcohol. In addition, the method for producing a liquid crystal emulsified cosmetic of the present invention was produced by the method for producing a liquid crystal mixed crystal emulsified composition using a lecithin derivative as a component exhibiting a diluent cloth when observed with a (G) polarizing microscope. It is characterized in that it is diluted with (H) water and (I) ethanol and / or water-soluble polyhydric alcohol and added to the liquid crystal mixed crystal emulsified composition. When the liquid crystal mixed crystal emulsified composition produced by the method for producing the liquid crystal mixed crystal emulsified composition is diluted with water or the like to form a lotion (soap), in order to make the emulsified particles finer, the above (B) The blending amount (mass%) of the higher alcohol, the (C) higher fatty acid soap and the (D) nonionic surfactant needs to be larger than the blending amount (mass%) of the oil content (A). , (D) The feeling of use of the nonionic surfactant may have an effect, resulting in heavy elongation and stickiness. Therefore, by using a lecithin derivative as a component that exhibits a maltese cloth when observed with the (G) polarizing microscope, the emulsified particles can be made fine even with a small amount of compounding, and the stability is good without reducing or causing creaming. Liquid crystal emulsified cosmetics such as lotions that spread lightly and are not sticky can be obtained. In the present invention, the "liquid crystal type emulsified cosmetic" is a cosmetic produced by adding water or the like to the liquid crystal mixed crystal type emulsified composition, and is a lotion (lotion), a milky lotion, or a gel-like makeup. It includes materials (essence) and the like.

In the present invention, the oil (A) is not limited as long as it can be used in cosmetics and the like, but basically it is a highly polar oil that dissolves higher alcohols, higher fatty acids, and nonionic surfactants well [IOB (Inorganic Organic). A balance) of 0.55 or more] is not very preferable because it makes it difficult to form a liquid crystal structure, and an oil having a relatively low polarity [IOB of less than 0.55, preferably 0.5 or less] is preferable. Examples of the oil (A) include vegetable oils such as silicone oil, liquid paraffin, squalane, synthetic isoparaffin, olive oil, jojoba oil, macadamian nut oil, and sesame oil, isopropyl myristate, octyldodecyl myristate, and tri-2-ethylhexane. Examples thereof include glyceryl acid (TIO), pentaerythrityl tetraethylhexanoate, and polyglyceryl-6 octacaprylate. Particularly preferable oil components include linear and cyclic low-viscosity silicones of dimethylpolysiloxane and methylphenylpolysiloxane, squalane, which is a non-polar oil, and glyceryl (TIO), which is a polar oil. Good to combine.

Further, in the present invention, as the higher alcohol (B), those having C12-C24 carbon atoms are preferable, and those having C16-C22 are more preferable. These higher alcohols may be used alone or in combination. When the number of carbon atoms is C12 or less, the solubility in water (hydration) increases, but a strong lamellar structure (layered structure) tends to be difficult to form. On the contrary, when the number of carbon atoms is C24 or more, emulsification is difficult (prone to lumps), and it tends to be difficult to form a lamellar structure.

Further, in the present invention, as the (C) higher fatty acid soap, a fatty acid soap having a saturated fatty acid having C12-C22 and a fatty acid soap having a hydroxy saturated fatty acid is preferable. Of these, fatty acid soaps having saturated fatty acids having C16-C22 carbon atoms are particularly preferable. Furthermore, the higher fatty acid soap may be used alone or in combination of two or more, and linear and branched fatty acid soaps may be used in combination. The alkali used to neutralize higher fatty acids and alkalis to make higher fatty acid soaps is ordinary cosmetics such as NaOH (sodium hydroxide), KOH (potassium hydroxide), arginine, and TEA (triethanolamine). Alkaline agents that can be used can be used. Stability is improved by blending it as a higher fatty acid soap instead of a higher fatty acid, and especially when diluted into a lotion, the stability is improved.

Further, in the present invention, as the (D) nonionic surfactant, it is important to appropriately adjust the HLB by combining a hydrophilic nonionic surfactant and a lipophilic nonionic surfactant. .. Specifically, it is preferable to adjust the HLB to the range of 7 to 15, more preferably to the range of 8 to 14, and even more preferably to the range of 8.8 to 13.0.

Specifically, the above-mentioned hydrophilic nonionic surfactant used in the present invention is preferably one having a relatively large hydrophilic group and a hydrophobic group, for example, a higher fatty acid ester containing 20 mol or more of polyoxyethylene (POE). And higher alcohol ether, phytosterol and cholesteryl ether with 15 mol or more of polyoxyethylene (POE), glycerin fatty acid ester with 10 mol or more of polyoxyethylene (POE), and hardened castor oil with 40 mol or more of polyoxyethylene (POE). Derivatives, polyglycerin higher fatty acid esters and the like are preferred.

Further, in the present invention, the lipophilic nonionic surfactant will be specifically described. As the lipophilic nonionic surfactant of this kind, those liquid at room temperature are not preferable, and semi-solid or solid. Molded ones are preferable. Specifically, a higher fatty acid ester of glycerin such as glyceryl monostearate, a higher fatty acid ester of propylene glycol such as propylene glycol monostearate, a higher fatty acid ester of pentaerythritol such as pentaerythritol monostearate, and sorbidan monostearate. Higher fatty acid esters of polyglycerin such as higher fatty acid esters of sorbidan, diglycerin monostearate, diglycerin isostearates, hexaglyceryl tristearate and the like are preferable.

Further, in the present invention, as the (D) nonionic surfactant, particularly preferable hydrophilic nonionic surfactant, polyoxyethylene hydrogenated castor oil containing 15 mol or more of polyoxyethylene (POE), cholesteryl ether. , Sterol ether, stearic acid or behenic acid ester, glyceryl is preferred. Examples of such hydrophilic nonionic surfactants include NIKKOL HCO-60 (trade name) manufactured by Nikko Chemicals Co., Ltd., NIKKOL DHC-30 (trade name), and EMALEX GWIS-115 manufactured by Nippon Emulsion Co., Ltd. Product name) etc. can be used. Of the above-mentioned hydrophilic nonionic surfactants, the larger the number of moles of polyoxyethylene (POE) added, the easier it is to form a liquid crystal structure, but from the viewpoint of usability, stickiness increases, which is not preferable. Further, in the present invention, examples of the nonionic surfactant include polyglycerin fatty acid ester and the like, such as NIKKOL DECAGLYN 1-SV (trade name) and NIKKOL DECAGLYN 1-ISV (trade name) manufactured by Nikko Chemicals Co., Ltd. ), NIKKOL DGMS (trade name), etc., but in this case, MONTANOV 202 (trade name) manufactured by Seiwa Kasei Co., Ltd. is used as a component exhibiting martese cloth when observed with the (G) polarization microscope. As a result, stickiness of NIKKOL DECAGLYN 1-SV (trade name) and the like can be reduced.

Furthermore, in the present invention, the (D) nonionic surfactant is not only fatty acid soap, but also other anionic (anionic) surfactants, amphoteric surfactants, and cationic (cationic) surfactants. It can be used in combination, but it goes without saying that skin safety must be taken into consideration in such cases. In the present invention, when an anionic (anionic) surfactant and a higher fatty acid soap are used in combination with the nonionic surfactant, there is an advantage that the temperature stability of the liquid crystal emulsion can be significantly improved. ..

Further, in the present invention, the (E) water-soluble polyhydric alcohol may have two or more hydroxyl groups in the molecule and may be generally used for cosmetics and external preparations. For example, propylene glycol, propanediol, 1,3 butylene glycol, dipropylene glycol, 1,4 butylene glycol, glycerin, polyglycerin, sorbitol, polyethylene glycol 300, polyethylene glycol 400, polyethylene glycol 1000, polyethylene glycol 1500, xylitol, man. Examples include knit, and one or more of these are used.

Further, in the present invention, from the viewpoint of facilitating the production of the liquid crystal mixed crystal emulsified composition and from the viewpoint of diluting the liquid crystal mixed crystal emulsified composition, the lower monohydric alcohol and the above-mentioned water-soluble polyhydric alcohol are used. Can be used together. As the lower monohydric alcohol of this kind, for example, lower monohydric alcohols such as C2-C3 ethyl alcohol and isopropyl alcohol are preferable.

Furthermore, in the present invention, the water (F) and the water (H) are not particularly limited as long as they are usually water that can be used in cosmetics and the like, but for example, purified water that is generally used. Pure water, ultrapure water, natural water, etc. can be used.

Further, the ethanol in the (I) ethanol and / or the water-soluble polyhydric alcohol is ethanol that can be usually used for cosmetics and the like, and the water-soluble polyhydric alcohol is the same as the (E) water-soluble polyhydric alcohol. Can be used.

Further, the liquid crystal mixed crystal emulsifying composition of the present invention has the (A) oil content of 0.5 to 40% by mass, and the (B) higher alcohol, the (C) higher fatty acid soap and the above ( D) The total amount of the nonionic surfactant blended is preferably 0.5 to 25% by mass, the blending amount of the (A) oil content is 1.0 to 35% by mass, and the above (B). The total amount of the higher alcohol, the (C) higher fatty acid soap and the D) nonionic surfactant is more preferably 0.5 to 20% by mass, and the amount of the oil (A) is 1. The total amount of the (B) higher alcohol, the (C) higher fatty acid soap, and the (D) nonionic surfactant is 0.7 to 17% by mass. Is even more preferable. The blending amount indicates the blending amount (mass%) in the liquid crystal mixed crystal emulsified composition.

Further, in the present invention, the liquid crystal mixed crystal emulsified composition and the liquid crystal emulsified cosmetic can be used on the human body and the like and are mainly cosmetics, but the use of quasi-drugs, pharmaceuticals and the like is excluded. is not it. Further, the cosmetics include basic cosmetics, cleansing cosmetics, make-up cosmetics, hair cosmetics, bath salts and the like.

Further, in the present invention, other components and the like can be appropriately added as long as the effects of the present invention are not impaired. Any ingredient other than the above can be blended within the qualitative and quantitative range, and ingredients normally blended in cosmetics, such as other surfactants, oily ingredients, moisturizers, antioxidants, fragrances, etc. Vitamin agents, chelating agents, coloring agents, ultraviolet absorbers, medicinal ingredients, inorganic salts and the like can be blended.

Examples of components that can be blended include polymer components such as xanthan gum, gellan gum, arabic gum, tragacanth gum, galactan, guar gum, carrageenan, pectin, agar, quince seed, dextran, purulan, casein, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl. Examples thereof include methyl cellulose, gelatin methyl cellulose, sodium alginate, carboxyvinyl polymer, acrylate / alkyl methacrylate copolymer and the like.

Extract components include, for example, chamomile extract, parsley extract, watermelon extract, rice extract, rice bran extract, hop extract, sardine extract, yokuinin extract, senburi extract, melilot extract, birch extract, kanzo extract, shakuyaku extract, sabonsou extract, and hechima extract. , Togarashi extract, lemon extract, gentiana extract, perilla extract, aloe extract, rosemary extract, sage extract, thyme extract, eucalyptus extract, tea extract, seaweed extract, cucumber extract, chowji extract, carrot extract, marronnier extract, hamamelis extract, quail extract , Chinpi extract, pecan nut extract, grapefruit extract, shikuwasa extract, passion fruit extract, biwa extract, grape extract, rose fruit extract, clara extract, peppermint extract and the like.

Examples of the moisturizing component include xylitol, sorbitol, maltitol, chondroitin sodium sulfate, elastin, glucosamine, hyaluronic acid, cyclodextrin, collagen, bile acid salt and the like.

As medicinal ingredients, for example, vitamins such as vitamin A, vitamin B, vitamin C, vitamin D, vitamin E and their derivatives, glycyrrhizinic acid and derivatives, glycyrrhetinic acid and derivatives, various salts such as urea, creatinine, CoQ10 , Astaxanthin, polyphenol, ceramide and other components.

Examples of the ultraviolet absorber include benzophenone derivatives such as 2-hydroxy-4-methoxybenzophenone, paraaminobenzoic acid derivatives such as paraaminobenzoic acid, methoxycinnamic acid derivatives such as octyl paramethoxycinnamic acid, and salicylic acid derivatives such as octyl salicylate and phenyl salicylate. , Urocanylic acid, ethyl urocanate, 4-tert-butyl-4'methoxydibenzoylmethane, benzotriazole and the like.

In the present invention, as the method for adding "(G) component exhibiting maltese cloth when observed with a polarizing microscope", a usual method for producing an emulsified composition or cosmetic can be used. Further, the addition temperature of the "component exhibiting maltese cloth when observed with a (G) polarizing microscope" is preferably 70 to 75 ° C., which is the emulsification temperature, but it may be added in the cooling process after emulsification or at room temperature. Good.

Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited to these Examples. The numbers in the table for the following prescriptions indicate mass%.

(Example 1, Example 2, Comparative Example 1)
According to the formulation shown in Table 1 below, the A phase and the C phase are mixed at 70 ° C. to produce a layered liquid crystal emulsified composition, and the component of the B phase dissolved in a part of the A phase is added and cooled. The liquid crystal mixed crystal type emulsified composition of Example 1 and Example 2 and the liquid crystal type emulsified composition of Comparative Example 1 were prepared. The obtained creamy liquid crystal mixed crystal emulsified composition and liquid crystal emulsified composition were observed with a polarizing microscope using CX41 manufactured by Olympus Corporation, and the results are also shown in Table 1 below. In addition, the following tactile test was performed, and the results are also shown in Table 1. In Table 1, * 1 is MONTANOV 202 (trade name) manufactured by Seiwa Kasei Co., Ltd., * 2 is NIKKOL DECAGLYN 1-SV (trade name) manufactured by Nikko Chemicals Co., Ltd., and * 3 is manufactured by Nikko Chemicals Co., Ltd. NIKKOL DECAGLYN 1-ISV (trade name), * 4 indicates NIKKOL MGS-BSE (trade name) manufactured by Nikko Chemicals Co., Ltd., * 5 indicates silicone DC-246 (trade name) manufactured by Toray Dow Corning Co., Ltd. ..

(Tactile test)
The subjects were 4 healthy male and female tactile measurement experienced persons (2 males and 2 females) aged 40 to 72 years (mean age 56 years), and each sample of the example was applied to the forearm of the subject. Then, "moist feeling", "spreading", and "familiarity with the skin" were evaluated by the following five-grade evaluation, and the average score was judged according to the following criteria.

(5-grade evaluation)
5 points: Very good 4 points: Somewhat good 3 points: Good 2 points: Normal 1 point: Bad

(Evaluation criteria)
Greater than 3.5 points on average ○
Greater than 2 average points and 3.5 points or less △
Average score 2 points or less ×

FIG. 1 is a diagram showing a polarizing micrograph of Example 1, FIG. 2 is a diagram showing a polarizing micrograph of Example 2, and FIG. 3 is a diagram showing a polarizing micrograph of Comparative Example 1. From the results of FIGS. 1 to 3 and Table 1, the liquid crystal mixed crystal emulsified compositions of Examples 1 and 2 can confirm the martese cloth under the observation with a polarizing microscope, have a good feel, and are not sticky. It was good. On the other hand, in the liquid crystal emulsified composition of Comparative Example 1, Martese cloth could not be confirmed under the observation with a polarizing microscope, the feel was poor, and the composition was sticky.

(Example 3, Example 4, Comparative Example 2)
According to the formulation shown in Table 2 below, in Example 3, a liquid crystal mixed crystal emulsified composition was prepared by mixing and cooling the B phase, the D phase, and the C phase dissolved in a part of the B phase at 70 ° C. A liquid crystal emulsified cosmetic was prepared by diluting with phase A. In Example 4, phosphatidylcholine (1% by mass of water, 1% by mass of 1,3-butylene glycol, 0.1% by mass of phosphatidylcholine) dissolved in a part of phase A while mixing and cooling the B phase and the D phase at 70 ° C. After mixing (% by mass) to prepare a liquid crystal mixed crystal emulsified composition, it was diluted with the balance of the A phase to prepare a liquid crystal emulsified cosmetic. The properties of the obtained liquid crystal emulsified cosmetic were visually observed, and the states are also shown in Table 2 below. Further, using a nanoparticle size distribution measuring device (SALD-7100) manufactured by Shimadzu Corporation, the particle size was measured by diluting it with water to 1%, and the results are also shown in Table 2 below. Furthermore, the stability over time after 1 month at room temperature was measured, and the results are also shown in Table 2 below. Stability was evaluated as ⊚ for the state without creaming / separation, ◯ for the state with some creaming, and × for the state with complete creaming.

A 20% aqueous solution of phosphatidylcholine was observed with a polarizing microscope using CX41 manufactured by Olympus Corporation. FIG. 4 is a diagram showing a polarizing micrograph of a 20% aqueous solution of phosphatidylcholine, and Martese cloth was confirmed. From the results of FIGS. 4 and 2, the liquid crystal emulsified cosmetics of Examples 3 and 4 had a liquid crystal mixed emulsified composition before dilution (addition of phase A), which was a mixed crystal of lamella and martese, and was diluted. The liquid crystal emulsified cosmetic (lotion) after the dilution had a good spread, a good feel without stickiness, and a good stability. On the other hand, in the liquid crystal emulsified cosmetic of Comparative Example 2, Martese cloth could not be confirmed in the liquid crystal emulsified composition before dilution (addition of phase A), and creaming occurred in the liquid crystal emulsified cosmetic (lotion) after dilution. It was confirmed and the stability was poor. Further, in the liquid crystal type emulsified cosmetic of Example 4, phosphatidylcholine is added in the A phase, but a layered liquid crystal is formed with fatty acid soap and dissolved in a part of the A phase in a conc state and added. Therefore, although the emulsified particles due to dilution were slightly large, they were easily mixed by shaking lightly, and there was no problem as compared with Comparative Example 2. However, when Example 3 and Example 4 are compared, it is possible to produce a better liquid crystal emulsified cosmetic by adding "a component exhibiting maltese cloth when observed with a (G) polarizing microscope" at 70 ° C. it can. Note that FIG. 5 is a diagram showing a four-fold photograph of the polarization micrograph of FIG. In order to show the scales of FIGS. 1 to 4, a figure enlarged by 4 times is shown by taking FIG. 4 as an example. 1 to 3 have the same scale.

(Example 5 and Example 6)
According to the formulation shown in Table 3 below, the B phase and the D phase are mixed at 70 ° C. to produce a layered liquid crystal emulsified composition, and the C phase component dissolved in a part of the B phase is added and cooled to form a liquid crystal. After preparing the mixed crystal emulsified composition, it was diluted with phase A to prepare the liquid crystal emulsified cosmetic (milky lotion) of Example 5 and the liquid crystal emulsified cosmetic (gel cosmetic, essence) of Example 6.

LCD type emulsion cosmetic of Examples 5 and 6 are both feel is good elongation was no stickiness good.

Claims (3)

(A) oil, (B) higher alcohols with C12 to C24 carbon atoms , (C) higher fatty acid soaps with C12 to C22 carbon atoms , (D) nonionic surfactants, (E) water-soluble polyhydric alcohols and (F) Water is heated and mixed to prepare a layered liquid crystal emulsifying composition.
A component exhibiting a martase cloth when observed with a (G) polarizing microscope is added to the layered liquid crystal emulsified composition, and the (G) marté is placed between the lamellar liquid crystal structures of the layered liquid crystal emulsified composition. Incorporate ingredients that exhibit zecross,
The component exhibiting maltese cloth when observed with the (G) polarizing microscope is an araquil glucoside or a lecithin derivative.
The lecithin derivative is phosphatidylcholine or hydrogenated lecithin.
The blending amount of the oil (A) is 0.5 to 40% by mass.
The total amount of the (B) higher alcohol having C12 to C24, the (C) higher fatty acid soap having C12 to C22, and the (D) nonionic surfactant is 11.94 to 25. % by mass it is,
(B) The blending amount of the higher alcohol having C12 to C24 carbon atoms is 2.48 to 9.24% by mass.
(C) the method of manufacturing a liquid crystal mixed crystal emulsion composition having a carbon number of the amount of the higher fatty acid soap C12~C22 is characterized from 1.14 to 2.27% by mass Rukoto. A lecithin derivative was used as a component exhibiting a maltese cloth when observed with a polarizing microscope (G), and a liquid crystal mixed crystal emulsified composition was produced by the method for producing a liquid crystal mixed crystal emulsified composition according to claim 1.
A method for producing a liquid crystal emulsified cosmetic, which comprises adding (H) water and (I) ethanol and / or a water-soluble polyhydric alcohol to dilute the mixture. The method for producing a liquid crystal emulsified cosmetic according to claim 2, wherein the liquid crystal emulsified cosmetic is one selected from the group consisting of a lotion, a milky lotion, and a gel-like cosmetic.

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