JP6904773B2 - Hair restorer composition - Google Patents

Description

The present invention relates to a hair restorer composition.

Conventionally, it is known that the hair loss suppressing effect and the hair growth promoting effect on hair can be obtained by continuously using a hair growth and nourishing agent for a long period of time. However, the conventional hair-growth hair-growth agent contains ethanol for stabilizing the hair-growth active ingredient in the hair-growth hair-growth agent (see, for example, Patent Document 1). Therefore, a consumer with a skin type that shows a hypersensitive reaction to ethanol has a problem that the hair-growth and nourishing agent cannot be used because the scalp is strongly irritated. In addition, even consumers who do not have sensitive skin will feel irritation in their eyes when the hair restorer drips into the eyes after applying the hair restorer to the scalp, so the hair restorer will not be used continuously. There's a problem.

Therefore, in order to stabilize the hair-growth active ingredient in the hair-growth hair-growth agent, a hair-growth hair-growth agent that solubilizes the hair-growth active ingredient by using a surfactant instead of ethanol has been proposed (see, for example, Patent Document 2).
However, the hair-growth and nourishing agent causes stickiness of hair and scalp, and has insufficient high-temperature storage stability and low-temperature storage stability. The lack of irritation to the eyes has not been examined.

Therefore, it is excellent in hair loss suppressing effect, hair growth promoting effect, hair non-stickiness, scalp non-stickiness, scalp non-irritating feeling, and eye irritation feeling, high temperature storage stability, and low temperature storage. It is desired to provide a hair restorer composition having good stability.

Japanese Unexamined Patent Publication No. 2006-213637 Japanese Unexamined Patent Publication No. 2015-187094

An object of the present invention is to solve the above-mentioned problems in the past and to achieve the following object. That is, the present invention is excellent in hair loss suppressing effect, hair growth promoting effect, non-sticky hair, non-sticky scalp, no irritating scalp, and no irritating eyes, and is stable at high temperature. , And it is an object of the present invention to provide a hair restorer composition having good stability at low temperature.

As a result of diligent studies by the present inventor in order to solve the above problems,
(A) Hair growth active ingredient and
(B) At least one polyhydric alcohol selected from glycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, and polyethylene glycol having an average molecular weight of 280 or more and 420 or less.
(C) Polyoxyethylene hydrogenated castor oil (C1) having an average number of moles of ethylene oxide added of 3 or more and less than 30, and polyoxyethylene hydrogenated castor oil (C2) having an average number of moles of ethylene oxide added of 30 or more.
(D) Higher fatty acids represented by the following general formula (1) and
R ₁ COOH ・ ・ ・ General formula (1)
(However, in the general formula (1), R ₁ represents a monovalent hydrocarbon group having 7 or more and 25 or less carbon atoms).
(E) Water 30% by mass or more and less than 98.7% by mass
(F) Ethanol contains 20% by mass or less and
The mass ratio (C1 / C2) of the content (mass%) of the component (C1) and the content (mass%) of the component (C2) is 0.05 or more and 10 or less. Due to the synergistic effect of each component, the hair restorer composition has a hair loss suppressing effect, a hair growth promoting effect, a non-sticky hair, a non-sticky scalp, a non-irritating scalp, and an irritating feeling to the eyes. It was found that the scalp was excellent, and the high-temperature storage stability and the low-temperature storage stability were good.

The present invention is based on the above-mentioned findings by the present inventors, and the means for solving the above-mentioned problems are as follows. That is,
<1> (A) Hair growth active ingredient and
(B) At least one polyhydric alcohol selected from glycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, and polyethylene glycol having an average molecular weight of 280 or more and 420 or less.
(C) Polyoxyethylene hydrogenated castor oil (C1) having an average number of moles of ethylene oxide added of 3 or more and less than 30, and polyoxyethylene hydrogenated castor oil (C2) having an average number of moles of ethylene oxide added of 30 or more.
(D) Higher fatty acids represented by the following general formula (1) and
R ₁ COOH ・ ・ ・ General formula (1)
(However, in the general formula (1), R ₁ represents a monovalent hydrocarbon group having 7 or more and 25 or less carbon atoms).
(E) Water 30% by mass or more and less than 98.7% by mass
(F) Ethanol contains 20% by mass or less and
The mass ratio (C1 / C2) of the content (mass%) of the component (C1) and the content (mass%) of the component (C2) is 0.05 or more and 10 or less. It is a hair restorer composition.
<2> The content of the component (A) is 0.1% by mass or more and 3% by mass or less.
The content of the component (B) is 1% by mass or more and 15% by mass or less.
The content of the component (C1) is 0.5% by mass or more and 3% by mass or less.
The content of the component (C2) is 0.5% by mass or more and 8% by mass or less.
The content of the component (D) is 2% by mass or more and 10% by mass or less.
The hair restorer composition according to <1>, wherein the content of the component (E) is 65% by mass or more and less than 98.7% by mass.

According to the present invention, the above-mentioned problems in the prior art can be solved and the above-mentioned object can be achieved, and the hair loss suppressing effect, the hair growth promoting effect, the non-sticky hair, the non-sticky scalp, and the stimulating feeling to the scalp can be achieved. It is possible to provide a hair restorer composition which is excellent in no irritability and no irritation to the eyes, and has good high-temperature storage stability and low-temperature storage stability.

(Hair growth agent composition)
The hair restorer composition of the present invention comprises (A) a hair restorer active ingredient, (B) a polyhydric alcohol, (C) polyoxyethylene hydrogenated castor oil, (D) a higher fatty acid, (E) water, and ( F) Ethanol contains 20% by mass or less, and if necessary, other components are contained.

<(A) Hair growth active ingredient>
The hair growth active ingredient of the component (A) is contained in order to improve the hair loss suppressing effect and the hair growth promoting effect.

The hair-growth active ingredient of the component (A) is not particularly limited and may be appropriately selected depending on the intended purpose. For example, 6-benzylaminopurine, pentadecanoic acid glyceride, minoxidil, capronium chloride, t-flavanone, hypericum erectum. Examples include extracts. These may be used alone or in combination of two or more.
Among these, 6-benzylaminopurine and pentadecanoic acid glyceride are preferable from the viewpoint of hair loss suppressing effect and hair growth promoting effect.

As the hair-growth active ingredient of the component (A), an appropriately synthesized product may be used, or a commercially available product may be used. Examples of the commercially available products include 6-benzylaminopurine (trade name: CTP, manufactured by Sansho Seiyaku Co., Ltd.), pentadecanoic acid glyceride (trade name: PDG, manufactured by Lion Corporation), and minoxidil (trade name: minoxidil, manufactured by Lion Corporation). Biotechnology Co., Ltd.) and the like. These may be used alone or in combination of two or more.

The content of the hair growth active ingredient of the component (A) is the total amount of the hair growth agent composition from the viewpoints of hair loss suppressing effect, hair growth promoting effect, non-stickiness of hair, non-stickiness of scalp, and stability at low temperature storage. On the other hand, 0.01% by mass or more and 5% by mass or less is preferable, and 0.1% by mass or more and 3% by mass or less is more preferable. If the content is less than 0.01% by mass, the hair loss suppressing effect and the hair growth promoting effect may be insufficient. On the other hand, if the content exceeds 5% by mass, the hair may not be sticky, the scalp may not be sticky, and the low-temperature storage stability may be insufficient.

<(B) Multivalent alcohol>
The polyhydric alcohol of the component (B) is contained in order to improve the stability at low temperature storage.

The polyhydric alcohol of the component (B) is at least one polyhydric alcohol selected from glycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, and polyethylene glycol having an average molecular weight of 280 or more and 420 or less. be.
Among these, propylene glycol, dipropylene glycol, and 1,3-butylene glycol are preferable from the viewpoint of low-temperature storage stability.

As the glycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, and polyethylene glycol of the component (B), those synthesized as appropriate may be used, or commercially available products may be used. Examples of the commercially available products include propylene glycol (trade name: propylene glycol, manufactured by ADEKA Co., Ltd.), dipropylene glycol (trade name: dipropylene glycol, manufactured by ADEKA Co., Ltd.), and 1,3-butylene glycol (trade name:). 1,3-butylene glycol, manufactured by Daicel Co., Ltd.), polyethylene glycol (trade name: PEG # 300, manufactured by Nichiyu Co., Ltd., average molecular weight: 280-320), polyethylene glycol (trade name: PEG # 400, Nichiyu Co., Ltd.) Made by the company, average molecular weight: 380 to 420) and the like. These may be used alone or in combination of two or more.

As the polyethylene glycol having an average molecular weight of 280 or more and 420 or less as the component (B), polyethylene glycol having an average molecular weight of 280 or more and 320 or less and polyethylene glycol having an average molecular weight of 380 or more and 420 or less are preferable. If the average molecular weight is less than 280, the lack of irritation to the scalp and the lack of irritation to the eyes may be insufficient. On the other hand, if the average molecular weight exceeds 420, the hair may not be sticky, the scalp may not be sticky, and the low-temperature storage stability may be insufficient.

The average molecular weight of the polyethylene glycol can be measured by, for example, an average molecular weight test of polyethylene glycol 300 listed in the Quasi-drug Raw Material Standard 2006 (published by Yakuji Nihonsha Co., Ltd.).

[Average molecular weight test of polyethylene glycol 300]
Put 1.5 g of polyethylene glycol precisely weighed in a 200 mL pressure-resistant stopper bottle A, add 25 mL of pyridine, heat to melt, and allow to cool. Accurately weigh 300 mL of distilled pyridine into another 1 L light-shielded stoppered bottle B, add 42 g of phthalic anhydride, shake vigorously to dissolve, and leave the mixture for 16 hours or more. Then, 25 mL of the solution in the pressure-resistant bottle B, which has been accurately weighed, is added to the pressure-resistant bottle A and sealed, and the pressure-resistant bottle A is wrapped in a durable cloth to bring the temperature to 98 ° C. ± 2 ° C. It is placed in a heated water bath and heated for 30 minutes so that the liquid in the pressure-resistant stopper bottle A is immersed in the water bath liquid. Then, leave it until it reaches room temperature.
Next, exactly 50 mL of 0.5 mol / L sodium hydroxide solution is added and titrated with 0.5 mol / L sodium hydroxide solution. For the titration, 5 drops of phenolphthalein pyridine solution 1 → 100 (a solution in which 1 g of phenolphthalein is dissolved in pyridine to make the total volume 100 mL) is used as an indicator. However, the end point of the titration is when the liquid exhibits a pale red color that lasts for 15 seconds. Perform a blank test in the same way.
The obtained value is applied to the following formula (1) to calculate the average molecular weight.
Average molecular weight = {sample amount (g) x 4000} / (ab) ... Equation (1)
However, a: consumption of 0.5 mol / L sodium hydroxide solution in the blank test (mL), b: consumption of 0.5 mol / L sodium hydroxide solution in the sample test (mL).

The content of the polyhydric alcohol of the component (B) is the total amount of the hair restorer composition from the viewpoints of hair loss suppressing effect, hair growth promoting effect, hair non-stickiness, scalp non-stickiness, and low temperature storage stability. On the other hand, it is preferably 0.1% by mass or more and 30% by mass or less, and more preferably 1% by mass or more and 15% by mass or less. If the content is less than 0.1% by mass, the low temperature storage stability may be insufficient. On the other hand, if the content exceeds 30% by mass, the hair loss suppressing effect, the hair growth promoting effect, and the non-stickiness of the scalp may be insufficient.

<(C) Polyoxyethylene hydrogenated castor oil>
The component (C) is contained in order to improve the non-irritating sensation to the scalp, the high temperature storage stability, and the low temperature storage stability.
The polyoxyethylene hydrogenated castor oil of the component (C) is a polyoxyethylene hydrogenated castor oil (C1) having an average ethylene oxide addition molar number of 3 or more and less than 30, and a polyoxyethylene hydrogenated castor oil having an average ethylene oxide addition molar number of 30 or more. Oxyethylene hydrogenated castor oil (C2).

<< Polyoxyethylene hydrogenated castor oil (C1) with an average number of moles of ethylene oxide added of 3 or more and less than 30 >>
The polyoxyethylene hydrogenated castor oil having an average number of moles of ethylene oxide added as the component (C1) of 3 or more and less than 30 is not particularly limited and may be appropriately selected depending on the intended purpose. Himasi oil (average number of moles of ethylene oxide added: 3), polyoxyethylene hydrogenated castor oil (average number of moles of ethylene oxide added: 5), polyoxyethylene hydrogenated castor oil (average number of moles of ethylene oxide added: 7), Polyoxyethylene hydrogenated castor oil (average number of moles of ethylene oxide added: 10), polyoxyethylene hydrogenated castor oil (average number of moles of ethylene oxide added: 20), polyoxyethylene hydrogenated castor oil (average number of moles of ethylene oxide added) : 25) and the like. These may be used alone or in combination of two or more.
Among these, polyoxyethylene hydrogenated castor oil having an average number of moles of ethylene oxide added of 5 or more and 20 or less is preferable from the viewpoint of not irritating the scalp and stability at low temperature.

As the polyoxyethylene hydrogenated castor oil in which the average number of moles of ethylene oxide added as the component (C1) is 3 or more and less than 30, an appropriately synthesized one may be used, or a commercially available product may be used. Examples of the commercially available product include polyoxyethylene hydrogenated castor oil (trade name: BLAUNON CW-3, manufactured by Aoki Yushi Kogyo Co., Ltd., average number of moles of ethylene oxide added: 3), polyoxyethylene hydrogenated castor oil (trade name). : NIKKOL HCO-5, manufactured by Nikko Chemicals Co., Ltd., average number of moles of ethylene oxide added: 5), polyoxyethylene hydrogenated castor oil (trade name: EMALX HC-5, manufactured by Nippon Emulsion Co., Ltd., average number of moles of ethylene oxide added) Number: 5), Polyoxyethylene hydrogenated castor oil (trade name: EMALEX HC-7, manufactured by Nippon Emulsion Co., Ltd., average number of moles of ethylene oxide added: 7), polyoxyethylene hydrogenated castor oil (trade name: NIKKOL HCO- 10, Nikko Chemicals Co., Ltd., average number of moles of ethylene oxide added: 10), polyoxyethylene hydrogenated castor oil (trade name: EMALX HC-10, manufactured by Nippon Emulsion Co., Ltd., average number of moles of ethylene oxide added: 10) , Polyoxyethylene hydrogenated castor oil (trade name: BLAUNON CW-10, manufactured by Aoki Yushi Kogyo Co., Ltd., average number of moles of ethylene oxide added: 10), polyoxyethylene hydrogenated castor oil (trade name: NIKKOL HCO-20, sunlight Chemicals Co., Ltd., average number of moles of ethylene oxide added: 20), polyoxyethylene hydrogenated castor oil (trade name: EMALX HC-20, manufactured by Nippon Emulsion Co., Ltd., average number of moles of ethylene oxide added: 20), polyoxy Ethethylene-hardened castor oil (trade name: BLAUNON RCW-20, manufactured by Aoki Yushi Kogyo Co., Ltd., average number of moles of ethylene oxide added: 20), polyoxyethylene-hardened castor oil (trade name: Uniox HC-20, Nichiyu Co., Ltd.) Company-made, average number of moles of ethylene oxide added: 20), polyoxyethylene hydrogenated castor oil (trade name: BLAUNON CW-25, manufactured by Aoki Yushi Kogyo Co., Ltd., average number of moles of ethylene oxide added: 25), etc. .. These may be used alone or in combination of two or more.

The content of polyoxyethylene hydrogenated castor oil having an average mass addition of ethylene oxide of 3 or more and less than 30 as the component (C1) is that the hair is not sticky, the scalp is not irritated, and the low temperature storage stability is achieved. From this point of view, 0.1% by mass or more and 5% by mass or less is preferable, and 0.5% by mass or more and 3% by mass or less is more preferable with respect to the total amount of the hair restorer composition. If the content is less than 0.1% by mass, the scalp may not be irritated and the low temperature storage stability may be insufficient. On the other hand, if the content exceeds 5% by mass, the non-stickiness of the hair may be insufficient.

<< Polyoxyethylene hydrogenated castor oil (C2) with an average number of moles of ethylene oxide added of 30 or more >>
The polyoxyethylene hydrogenated castor oil having an average number of moles of ethylene oxide added as the component (C2) of 30 or more is not particularly limited and may be appropriately selected depending on the intended purpose. For example, polyoxyethylene hydrogenated castor oil. (Average number of moles of ethylene oxide added: 30), polyoxyethylene hydrogenated castor oil (average number of moles of ethylene oxide added: 40), polyoxyethylene hydrogenated castor oil (average number of moles of ethylene oxide added: 50), polyoxy Ethylene-hardened castor oil (average number of moles of ethylene oxide added: 60), polyoxyethylene-hardened castor oil (average number of moles of ethylene oxide added: 80), polyoxyethylene-hardened castor oil (average number of moles of ethylene oxide added: 100) ), Polyoxyethylene hydrogenated castor oil (average number of moles of ethylene oxide added: 150), polyoxyethylene hydrogenated castor oil (average number of moles of ethylene oxide added: 200), and the like. These may be used alone or in combination of two or more.
Among these, polyoxyethylene hydrogenated castor oil having an average number of moles of ethylene oxide added of 40 or more and 100 or less is preferable from the viewpoint of not irritating the scalp and stability at high temperature.

As the polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of the component (C2) of 30 or more, an appropriately synthesized one may be used, or a commercially available product may be used. Examples of the commercially available product include polyoxyethylene hydrogenated castor oil (trade name: NIKKOL HCO-30, manufactured by Nikko Chemicals Co., Ltd., average number of moles of ethylene oxide added: 30), polyoxyethylene hydrogenated castor oil (trade name:). EMALEX HC-30, manufactured by Nippon Emulsion Co., Ltd., average number of moles of ethylene oxide added: 30), polyoxyethylene hydrogenated castor oil (trade name: NIKKOL HCO-40, manufactured by Nikko Chemicals Co., Ltd., average number of moles of ethylene oxide added) : 40), Polyoxyethylene hydrogenated castor oil (trade name: EMALX HC-40, manufactured by Nippon Emulsion Co., Ltd., average number of moles of ethylene oxide added: 40), polyoxyethylene hydrogenated castor oil (trade name: BLAUNON CW-40) , Aoki Yushi Kogyo Co., Ltd., average number of moles of ethylene oxide added: 40), polyoxyethylene hydrogenated castor oil (trade name: BLAUNON RCW-40, manufactured by Aoki Yushi Kogyo Co., Ltd., average number of moles of ethylene oxide added: 40) ), Polyoxyethylene hydrogenated castor oil (trade name: Uniox HC-40, manufactured by Nichiyu Co., Ltd., average number of moles of ethylene oxide added: 40), polyoxyethylene hydrogenated castor oil (trade name: NIKKOL HCO-50, Nikko Chemicals Co., Ltd., average number of moles of ethylene oxide added: 50), polyoxyethylene hydrogenated castor oil (trade name: EMALX HC-50, manufactured by Nippon Emulsion Co., Ltd., average number of moles of ethylene oxide added: 50), poly Oxyethylene hydrogenated castor oil (trade name: BLAUNON RCW-50, manufactured by Aoki Yushi Kogyo Co., Ltd., average number of moles of ethylene oxide added: 50), polyoxyethylene hydrogenated castor oil (trade name: NIKKOL HCO-60, Nikko Chemicals Co., Ltd.) Company manufactured, average number of moles of ethylene oxide added: 60), polyoxyethylene hydrogenated castor oil (trade name: EMALX HC-60, manufactured by Nippon Emulsion Co., Ltd., average number of moles of ethylene oxide added: 60), polyoxyethylene hydrogenated Himasi oil (trade name: BLAUNON RCW-60, manufactured by Aoki Yushi Kogyo Co., Ltd., average number of moles of ethylene oxide added: 60), polyoxyethylene hydrogenated castor oil (trade name: Uniox HC-60, manufactured by Nichiyu Co., Ltd.) , Average number of moles of ethylene oxide added: 60), Polyoxyethylene hydrogenated castor oil (trade name) : NIKKOL HCO-80, manufactured by Nikko Chemicals Co., Ltd., average number of moles of ethylene oxide added: 80), polyoxyethylene hydrogenated castor oil (trade name: EMALX HC-80, manufactured by Nippon Emulsion Co., Ltd., average number of moles of ethylene oxide added) Number: 80), Polyoxyethylene hydrogenated castor oil (trade name: BLAUNON RCW-80, manufactured by Aoki Yushi Kogyo Co., Ltd., average number of moles of ethylene oxide added: 80), polyoxyethylene hydrogenated castor oil (trade name: NIKKOL HCO) -100, Nikko Chemicals Co., Ltd., average number of moles of ethylene oxide added: 100), polyoxyethylene hydrogenated castor oil (trade name: EMALX HC-100, manufactured by Nippon Emulsion Co., Ltd., average number of moles of ethylene oxide added: 100) ), Polyoxyethylene hydrogenated castor oil (trade name: BLAUNON CW-100, manufactured by Aoki Yushi Kogyo Co., Ltd., average number of moles of ethylene oxide added: 100), polyoxyethylene hydrogenated castor oil (trade name: BLAUNON RCW-100, Aoki Yushi Kogyo Co., Ltd., average number of moles of ethylene oxide added: 100), polyoxyethylene hydrogenated castor oil (trade name: Uniox HC-100, manufactured by Nikko Co., Ltd., average number of moles of ethylene oxide added: 100) , Polyoxyethylene hydrogenated castor oil (trade name: BLAUNON CW-150, manufactured by Aoki Yushi Kogyo Co., Ltd., average number of moles of ethylene oxide added: 150), polyoxyethylene hydrogenated castor oil (trade name: BLAUNON CW-200, Aoki) The average number of moles of ethylene oxide added, manufactured by Yushi Kogyo Co., Ltd .: 200) and the like. These may be used alone or in combination of two or more.

The content of polyoxyethylene hydrogenated castor oil having an average mass of ethylene oxide added as the component (C2) of 30 or more is that the hair is not sticky, the scalp is not irritated, and the storage stability at high temperature is high. Therefore, it is preferably 0.1% by mass or more and 10% by mass or less, and more preferably 0.5% by mass or more and 8% by mass or less with respect to the total amount of the hair restorer composition. If the content is less than 0.1% by mass, the scalp may not be irritated and the high temperature storage stability may be insufficient. On the other hand, if the content exceeds 10% by mass, the non-stickiness of the hair may be insufficient.

[Mass ratio (C1 / C2)]
The mass ratio (C1 / C2) of the content (mass%) of the component (C1) and the content (mass%) of the component (C2) is as follows: high temperature storage stability and low temperature storage stability. From the point of view, it is 0.05 or more and 10 or less, preferably 0.2 or more and 2 or less. If the mass ratio (C1 / C2) is less than 0.05, the low temperature storage stability may be insufficient. Further, if the mass ratio (C1 / C2) exceeds 10, the high temperature storage stability may be insufficient.

<(D) Higher fatty acid>
The higher fatty acid of the component (D) is contained in order to improve the high temperature storage stability and the low temperature storage stability.
The higher fatty acid of the component (D) is represented by the following general formula (1).
R ₁ COOH ・ ・ ・ General formula (1)
(However, in the general formula (1), R ₁ represents a monovalent hydrocarbon group having 7 or more and 25 or less carbon atoms).
The monovalent hydrocarbon group is a saturated or unsaturated linear or branched chain, and a part of hydrogen atoms of the monovalent hydrocarbon group may be substituted with a hydroxyl group.

The higher fatty acid of the component (D) is not particularly limited and may be appropriately selected depending on the intended purpose. For example, capric acid ( _{carbon number of R 1} : 7), 2-ethylhexanoic acid (R ₁ ). Carbon number: 7, including branched chain, pelargonic acid (R ₁ carbon number: 8), isononanoic acid (R ₁ carbon number: 8, including branched chain), 3,5,5-trimethylhexanoic acid (R ₁₎ Carbon number: 8, including branched chains, capric acid (R ₁ carbon number: 9), caproleic acid (R ₁ carbon number: 9, R ₁ unsaturated degree: 1), undecanoic acid (R _{1 carbon number: 1)} Carbon number: 10), undecylene acid (R ₁ carbon number: 10, R ₁ unsaturated degree: 1), lauric acid (R ₁ carbon number: 11), lauroreic acid (R ₁ carbon number: 11, R ₁ unsaturated degree: 1), tridecanoic acid (R ₁ carbon number: 12), tetramethylnonanoic acid (R ₁ carbon number: 12, including branched chain), myristic acid (R ₁ carbon number: 13) ), Myristolenic acid (R ₁ carbon number: 13, R ₁ unsaturated degree: 1), pentadecanoic acid (R ₁ carbon number: 14), 2-hexyl decanoic acid (R ₁ carbon number: 15, branched (Including chains), palmitic acid (R ₁ carbon number: 15), palmitrenic acid (R ₁ carbon number: 15, R ₁ unsaturated degree: 1), stearic acid (R ₁ carbon number: 17), isostear Acid (R ₁ carbon number: 17, including branched chain), 12-hydroxystearic acid (R ₁ carbon number: 17, including hydroxyl group), oleic acid (R ₁ carbon number: 17, R ₁ unsaturated degree) 1), ellaic acid (R ₁ carbon number: 17, R ₁ unsaturated degree: 1), linoleic acid (R ₁ carbon number: 17, R ₁ unsaturated degree: 2), linoleic acid (1) R ₁ carbon number: 17, R ₁ unsaturated degree: 2), linolenic acid (R ₁ carbon number: 17, R ₁ unsaturated degree: 3), araquinic acid (R ₁ carbon number: 19) , Gondoic acid (R ₁ carbon number: 19, R ₁ unsaturated degree: 1), arachidonic acid (R ₁ carbon number: 19, R ₁ unsaturated degree: 4), behenic acid (R _{1 carbon number: 4)} number: 21), the carbon number of erucic acid _{(R 1:} 21, _{R 1} degree of unsaturation: 1), lignoceric acid (number of carbon atoms in _{R 1:} 23), the carbon number of selacholeic acid _{(R 1:} 23, R ₁ degrees of unsaturation: 1), cerotic acid (number of carbon atoms in _{R 1:} 25), and the like. These may be used alone or in combination of two or more.
_{Among these, lauric acid (R 1} carbon number: 11), myristic acid (R ₁ carbon number: 13), palmitic acid (R ₁ carbon number: 11), from the viewpoint of low temperature storage stability and high temperature stability. 15), stearic acid ( _{carbon number of R 1} : 17), isostearic acid ( _{carbon number of R 1} : 17, including branched chain) are preferable, and isostearic acid is more preferable.

As the higher fatty acid of the component (D), those synthesized as appropriate may be used, or commercially available products may be used. The commercially available product, for example, lauric acid (trade name: NAA-122, manufactured by NOF Corporation, number of carbon atoms in _{R 1:} 11), laurate (trade name: lauric acid 98, Miyoshi Oil & Fat Co., R ₁ carbon number: 11), myristic acid (trade name: NAA-142, manufactured by Nichiyu Co., Ltd., R ₁ carbon number: 13), myristic acid (trade name: myristic acid 98, manufactured by Miyoshi Oil & Fat Co., Ltd., R ₁ carbon number: 13), palmi myristic acid (trade name: NAA-160, manufactured by Nichiyu Co., Ltd., R ₁ carbon number: 15), palmitic acid (trade name: palmitic acid 98, manufactured by Miyoshi Oil & Fat Co., Ltd., R) ₁ carbon number: 15), stearic acid (trade name: NAA-180, manufactured by Nichiyu Co., Ltd., R ₁ carbon number: 17), stearic acid (trade name: STEARIC ACID 98%, manufactured by Miyoshi Oil & Fat Co., Ltd., R ₁ carbon number: 17), isostearic acid (trade name: isostearic acid EX, manufactured by Higher Alcohol Industry Co., Ltd., R ₁ carbon number: 17, including branched chain), isostearic acid (trade name: HAIMARIC-MKH, high grade) Alcohol Industry Co., Ltd., R ₁ carbon number: 17, including branched chains) and the like. These may be used alone or in combination of two or more.

The content of the higher fatty acid of the component (D) includes hair loss suppressing effect, hair growth promoting effect, no scalp irritation, no eye irritation, high temperature storage stability, and low temperature storage stability. From the point of view, it is preferably 1% by mass or more and 20% by mass or less, and more preferably 2% by mass or more and 10% by mass or less with respect to the total amount of the hair restorer composition. If the content is less than 1% by mass, the high temperature storage stability and the low temperature storage stability may be insufficient. When the content exceeds 20% by mass, the hair loss suppressing effect, hair growth promoting effect, no scalp irritation, no eye irritation, high temperature storage stability, and low temperature storage stability are exhibited. May be inadequate.

<(E) Water>
The water of the component (E) is contained to improve the non-stickiness of hair, the non-stickiness of scalp, the non-irritating feeling to the scalp, and the non-irritating feeling to the eyes.

The water of the component (E) is not particularly limited and may be appropriately selected depending on the intended purpose. For example, pure water such as purified water, ion-exchanged water, ultra-filtered water, reverse osmosis water, distilled water and the like. , Ultrapure water and the like. These may be used alone or in combination of two or more.
As the water of the component (E), a commercially available product may be used.

The water content of the component (E) is the total amount of the hair restorer composition from the viewpoints of non-stickiness of hair, non-stickiness of scalp, no irritation to scalp, and no irritation to eyes. On the other hand, it is preferably 30% by mass or more and less than 98.7% by mass, preferably 65% by mass or more and less than 98.7% by mass, and more preferably 65% by mass or more and 95.9% by mass or less. When the content is less than 30% by mass, the hair is not sticky, the scalp is not sticky, the scalp is not irritated, and the eyes are not irritated.
The water content of the component (E) is the content containing water contained in the extracts when extracts such as plant extracts are contained as other components.

<(F) Ethanol>
When the hair restorer composition of the present invention does not contain (F) ethanol or contains (F) ethanol, the above (F) is not irritating to the scalp and is not irritating to the eyes. ) The content (% by mass) of the component does not exceed 20% by mass.

The ethanol of the component (F) is not particularly limited and may be appropriately selected depending on the intended purpose. For example, absolute ethanol, 95% volume ethanol (standard value 95.2% by volume to 95.4% by volume, etc.). Content as absolute ethanol) and the like. These may be used alone or in combination of two or more.
As the ethanol of the component (F), a commercially available product may be used.

When the 95% by volume ethanol is used, the content (mass%) converted into absolute ethanol is the following formula (2) (Document 038-1309.pdf sent by Pharmaceuticals and Medical Devices Agency) and formula (PDF). It can be obtained in 3).
-Mass% of ethanol = volume% x 0.79422 (100% by volume specific gravity at 15 ° C.) / d (specific gravity at 15 ° C.) ... Equation (2)
= (95 × 0.79422) /0.81639
= 92.42
-Absolute ethanol content (mass%) = 95% by volume ethanol content (mass%) x 92.42 / 100 ... Equation (3)

The content of ethanol of the component (F) is 20% by mass or less as absolute ethanol with respect to the total amount of the hair restorer composition from the viewpoint of no irritation to the scalp and no irritation to the eyes. Yes, it is preferably 10% by mass or less. If the content exceeds 20% by mass, the lack of irritation to the scalp and the lack of irritation to the eyes may be insufficient.
The ethanol content of the component (F) is the content containing ethanol contained in the extracts when extracts such as plant extracts are contained as other components.

<Other ingredients>
In addition to the above-mentioned components (A) to (F), the hair restorer composition of the present invention includes components usually used in the hair restorer composition and the like, if necessary, as long as the effects of the present invention are not impaired. Can be blended as other ingredients.
The other components are not particularly limited and may be appropriately selected depending on the intended purpose. For example, nonionic surfactants, semipolar surfactants, amphoteric surfactants and anionic surfactants other than the component (C) are used. Polymers, nonionic polymers, polyhydric alcohols other than component (B), organic salts, moisturizers, tonic agents, solubilizers, antioxidants such as dibutylhydroxytoluene and α-tocopherol, sterilization of triclosan, trichlorocarban, etc. Agents, viscosity modifiers such as fatty acid monoethanolamides and fatty acid diethanolamides, UV absorbers, antioxidants, protein derivatives, animal and plant extracts, anti-solvents such as pyrocton olamine and zincpyrythione, anti-inflammatory agents such as dipotassium glycyrrhizinate Agents, benzoic acid and its salts, parabens, preservatives such as Kason CG, pH adjusters, pearlizing agents such as ethylene glycol difatty acid esters, emulsions, vitamins, volatile oils, hydrophobic solvents, dilutable Examples include solvents, extracts, pigments, fragrances and the like. These may be used alone or in combination of two or more.

<< pH regulator >>
The pH adjuster is not particularly limited and may be appropriately selected depending on the intended purpose. For example, citric acid, sodium citrate, succinic acid, sulfuric acid, 2-amino-2-methyl-1-propanol and mono. Ethanolamine, triethanolamine, or salts thereof, sodium hydroxide, potassium hydroxide and the like can be mentioned.

[PH]
The pH of the hair restorer composition is not particularly limited and may be appropriately selected depending on the intended purpose, but is preferably 3 or more and 8 or less in an environment of 25 ° C. If the pH is less than 3, the lack of irritation to the scalp and the lack of irritation to the eyes may be insufficient. Further, when the pH exceeds 8, the lack of irritation to the scalp and the lack of irritation to the eyes may be insufficient.

The pH can be measured in an environment of 25 ° C. by, for example, a pH meter (device name: HM-30G, manufactured by DKK-TOA CORPORATION).

-Manufacturing method-
The method for producing the hair restorer composition is not particularly limited and may be appropriately selected depending on the intended purpose. For example, the component (A), the component (B), the component (C), and the component (D). ) Components and, if necessary, the other components are uniformly mixed at a specific temperature using a three-one motor, a tilt paddle, or the like to obtain a mixed solution A.
Further, the component (E) and, if necessary, the component (F) are uniformly mixed at room temperature using a three-one motor, an inclined paddle, or the like to obtain a mixed liquid B.
After confirming that the mixed solution A and the mixed solution B are uniformly mixed, the mixed solution A is slowly dropped into the mixed solution B and mixed uniformly, thereby causing the hair restorer. The composition can be obtained.

-Container-
The container for accommodating the hair restorer composition is not particularly limited and may be appropriately selected depending on the intended purpose. For example, a tube container, a mechanical or differential pressure dispenser container and a squeeze container, a laminated film container, and a dropper. Examples include containers, stick containers, bottle containers and the like.
Examples of the tube container include an aluminum laminated tube, an EVAL tube, an aluminum tube, and a glass-deposited plastic tube.
The aluminum laminated tube preferably has a laminated film.
Examples of the material of the laminated film of the laminated film container include synthetic resin, paper, and aluminum-deposited plastic.
Examples of the synthetic resin include polyethylene resin, polyethylene terephthalate resin, polyester resin, biaxially stretched polypropylene resin, non-stretched polypropylene resin, polyacrylonitrile resin, ethylene-vinyl acetate copolymer resin and the like.
The layer of the laminated film is preferably 2 or more and 5 or less from the viewpoint of strength, flexibility, weather resistance and the like.
Examples of the material of the bottle container include resin and glass.
Examples of the resin include polyethylene resin, polypropylene resin, polyethylene terephthalate resin, polystyrene resin, polyvinyl chloride resin, ethylene-vinyl alcohol copolymer resin, acrylonitrile-styrene copolymer resin, ABS resin, polyamide resin and the like.
In the container, the layers of the material may be used as a single layer, or two or more layers may be combined.

-Use-
The hair restorer composition is excellent in hair loss suppressing effect, hair growth promoting effect, hair non-stickiness, scalp non-stickiness, scalp non-irritating feeling, and eye non-irritating feeling, and is stored at high temperature. Since the stability and the stability at low temperature are improved, it can be suitably used, for example, as a hair restorer, a hair restorer, a blood circulation promoter, a hair loss inhibitor, and the like.
As the hair growth agent, for example, it can be suitably used for external use of the scalp in the form of a hair growth tonic, an essence for the scalp, a hair growth spray, a hair growth hair gel, and the like.

Hereinafter, examples of the present invention will be described, but the present invention is not limited to these examples. The contents of each component described in Examples and Comparative Examples are all values converted to pure content.

(Examples 1 to 51 and Comparative Examples 1 to 21)
As shown in the compositions and contents (% by mass) shown in Tables 1 to 10 below, the hair restorer compositions of Examples 1 to 51 and Comparative Examples 1 to 21 were prepared based on the following production methods.

-Preparation of hair restorer composition-
Ingredients (A), (B), (C), (D), and other ingredients are combined with a three-one motor (trade name: HEIDEN FBLHEIDEN 1200, manufactured by Shinto Kagaku Co., Ltd.), and a four-piece tilted paddle. Was mixed uniformly at 80 ° C. to obtain a mixed solution A.
Further, the components (E) and (F) were uniformly mixed at room temperature (25 ° C.) using a three-one motor and four tilted paddles to obtain a mixed solution B.
After confirming that the mixed liquid A and the mixed liquid B are uniformly mixed, the mixed liquid A is slowly dropped into the mixed liquid B and mixed uniformly, whereby Example 1 The hair restorer compositions of ~ 51 and Comparative Examples 1 to 21 were obtained.

Regarding the obtained hair growth agent compositions of Examples 1 to 51 and Comparative Examples 1 to 21, "hair loss suppressing effect", "hair growth promoting effect", "non-stickiness of hair", "non-stickiness of scalp" , "No irritation to the scalp", "No irritation to the eyes", "High temperature storage stability", and "Low temperature storage stability" were evaluated by the following methods. The results are shown in Tables 1 to 10 below.

<Hair loss suppression effect and hair growth promotion effect>
The obtained hair restorer composition was applied to 40 ordinary women in their 50s to 60s twice a day, 1.5 mL each time on the entire scalp, and used continuously for 1 month. The number of hair loss after continuous use was observed, and the "hair loss inhibitory effect" was evaluated based on the following evaluation criteria based on the number of people who judged that "hair loss was reduced" compared to before the use of the hair restorer. In addition, based on the following evaluation criteria, the "hair growth promoting effect" was determined by the number of people who observed the amount of hair after continuous use and judged that "there was a feeling that the hair had increased" compared to before using the hair restorer. evaluated.
-Evaluation criteria for hair loss suppression effect-
⊚: 36 or more and 40 or less responded that “hair loss decreased” ○: 28 or more and 35 or less responded that “hair loss decreased” △: “Reduced hair loss” The number of people who answered "I did" was 20 or more and 27 or less. ×: The number of people who answered "Hair loss decreased" was 19 or less-Evaluation criteria for hair growth promoting effect-
⊚: The number of people who answered “I feel that my hair has increased” is 36 or more and 40 or less. ○: The number of people who answered “I feel that my hair has increased” is 28 or more and 35 or less. Δ: The number of people who answered “I feel that my hair has increased” is 20 or more and 27 or less. ×: The number of people who answered “I feel that my hair has increased” is 19 or less.

<Non-stickiness of hair, non-stickiness of scalp, and lack of irritation to scalp>
For 20 ordinary women in their 40s and 60s, after washing their hair with shampoo (trade name: Botanical Story Shampoo H1, manufactured by Lion Corporation), the obtained hair restorer composition is applied in a towel-dried state. 1.5 mL was applied to the entire scalp at a time. Based on the following evaluation criteria, "non-sticky hair" and "non-sticky scalp" were judged by the number of people who judged "good" for non-sticky hair, non-sticky scalp, and non-irritating scalp. "Noneness" and "no stimulus to the scalp" were evaluated.
The term "sticky hair" refers to a state in which the hair becomes sticky or sticks to each other when the hair is touched.
-Evaluation criteria for non-stickiness of hair-
⊚: 15 or more and 20 or less people answered “good” ○: 11 or more and 14 or less people answered “good” △: 7 people answered “good” More than 10 people and less than 10 people ×: 6 or less people answered “good” -Evaluation criteria for non-stickiness of the scalp-
⊚: 15 or more and 20 or less people answered “good” ○: 11 or more and 14 or less people answered “good” △: 7 people answered “good” More than 10 people and less than 10 people ×: 6 or less people answered “good” -Evaluation criteria for lack of irritation to the scalp-
⊚: 15 or more and 20 or less people answered “good” ○: 11 or more and 14 or less people answered “good” △: 7 people answered “good” More than 10 people or less ×: 6 or less people answered “good”

<No irritation to the eyes>
After washing the hair with shampoo (trade name: Botanical Story Shampoo H1, manufactured by Lion Corporation) for three male specialist panelists, in a towel-dried state, apply the obtained hair restorer composition to the hairline of the frontal region. 1.5 mL was applied. Based on the following evaluation criteria, "no irritation to the eyes" was evaluated by the number of people who judged that "there was no irritation when they got into the eyes". If it did not get in the eyes, the hair was washed and towel-dried, and the application was performed again.
-Evaluation criteria-
⊚: 3 people answered “no irritation when in eyes” ○: 2 people answered “no irritation when in eyes” △: One person answered that "there is no irritation when it gets into the eyes". ×: All three responded that "there is a feeling of irritation when it gets into the eyes."

<High temperature storage stability>
50 g of the obtained hair restorer composition is filled in a glass vial (trade name: SV-50A, manufactured by Nichiden Rika Glass Co., Ltd.) having a capacity of 50 g, stored in a constant temperature bath at 50 ° C. for 1 month, and then stored in the constant temperature bath. Immediately after taking out from the above, the appearance of the hair restorer composition was visually observed, and "high temperature storage stability" was evaluated based on the following evaluation criteria.
-Evaluation criteria-
⊚: Hair restorer composition is not separated ○: Transparent layer is slightly visible in the upper and / or lower layers of the hair restorer composition, but is not separated ×: Hair restorer composition is separated

<Cryopreservation stability>
50 g of the obtained hair restorer composition is filled in a glass vial (trade name: SV-50A, manufactured by Nichiden Rika Glass Co., Ltd.) having a capacity of 50 g, stored in a constant temperature bath at -5 ° C for 1 month, and then kept at the constant temperature. After taking out from the tank and allowing to stand at 25 ° C. for 60 minutes, the appearance of the hair restorer composition was visually observed, and "low temperature storage stability" was evaluated based on the following evaluation criteria.
-Evaluation criteria-
⊚: No precipitate is observed at -5 ° C and no precipitate is observed at 25 ° C. ○: Precipitate is observed at -5 ° C, but no precipitate is observed at 25 ° C ×: At -5 ° C Precipitates are observed, and precipitates are observed even at 25 ° C.

The raw materials of the hair restorer composition used in Examples 1 to 51 and Comparative Examples 1 to 21 are as shown in Table 11 below.

The hair restorer composition of the present invention is excellent in hair loss suppressing effect, hair growth promoting effect, hair non-stickiness, scalp non-stickiness, scalp non-irritating feeling, and eye non-irritating feeling, and is excellent in high temperature. It has good storage stability and low-temperature storage stability, and can be suitably used, for example, as a hair restorer, a hair restorer, a blood circulation promoter, a hair loss inhibitor, and the like.
As the hair growth agent, for example, it can be suitably used for external use of the scalp in the form of a hair growth tonic, an essence for the scalp, a hair growth spray, a hair growth hair gel, and the like.

Claims (2)

(A) Hair growth active ingredient and
(B) At least one polyhydric alcohol selected from glycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, and polyethylene glycol having an average molecular weight of 280 or more and 420 or less.
(C) Polyoxyethylene hydrogenated castor oil (C1) having an average number of moles of ethylene oxide added of 3 or more and less than 30, and polyoxyethylene hydrogenated castor oil (C2) having an average number of moles of ethylene oxide added of 30 or more.
(D) Higher fatty acids represented by the following general formula (1) and
R ₁ COOH ・ ・ ・ General formula (1)
(However, in the general formula (1), R ₁ represents a monovalent hydrocarbon group having 7 or more and 25 or less carbon atoms).
(E) Water 30% by mass or more and less than 98.7% by mass
(F) Ethanol contains 20% by mass or less and
The mass ratio (C1 / C2) of the content (mass%) of the component (C1) and the content (mass%) of the component (C2) is 0.05 or more and 10 or less. Hair restorer composition. The content of the component (A) is 0.1% by mass or more and 3% by mass or less.
The content of the component (B) is 1% by mass or more and 15% by mass or less.
The content of the component (C1) is 0.5% by mass or more and 3% by mass or less.
The content of the component (C2) is 0.5% by mass or more and 8% by mass or less.
The content of the component (D) is 2% by mass or more and 10% by mass or less.
The hair restorer composition according to claim 1, wherein the content of the component (E) is 65% by mass or more and 95.9 % by mass or less.