JP6908965B2 - Denture stabilizer - Google Patents

Description

The present invention relates to a denture stabilizer. More specifically, the present invention relates to a denture stabilizer which is excellent in adhesiveness and adhesive stability in the presence of water and can stably immobilize a denture in the oral cavity.

Denture stabilizers have traditionally been used by many denture wearers to fix dentures in place in the oral cavity during non-chewing and chewing.

Commercially available denture stabilizers include a water-soluble polymer such as sodium carboxymethyl cellulose or polyethylene glycol dispersed in an oil-based base such as liquid paraffin or vaseline, and the adhesive strength of the water-soluble polymer swollen by the moisture in the oral cavity causes the denture. Ointment or cream type denture stabilizer that improves the stability of dentures, and cushion type denture stability that fills the gap between the denture and the ridge mucosa by plasticizing polyvinyl acetate with a solvent such as ethanol. In addition to agents, there are gel type, powder type, sheet type, and tape type denture stabilizers. In any form, it is important that the denture exhibits good stickiness when placed in the mouth and that the stickiness lasts for a long time.

Therefore, many improvements have been proposed for denture stabilizers. For example, conventionally, artificial tooth stabilizers using lower alkyl vinyl ether / maleic anhydride copolymers, derivatives thereof, and salts thereof have been known to have good adhesiveness when containing water (for example, patents). (Refer to Document 1 etc.), Patent Document 2 includes a partially neutralized product of alkyl vinyl ether-maleic acid or a prosthetic tooth stabilizer containing the anhydrous copolymer and hydroxypropyl cellulose which may be partially crosslinked. 3 discloses an improved artificial tooth stabilizer-based composition containing a Na / Ca mixed salt of a methyl vinyl ether-maleic anhydride copolymer, a substantially anhydrous mixture of sodium carboxymethyl cellulose and a trivalent cation. Further, Patent Document 4 further describes a dentifrice adhesive containing, as an adhesive salt, a partial salt of a copolymer of maleic anhydride or maleic anhydride and an alkyl vinyl ether (the cation of the salt contains zinc ion and magnesium ion). Patent Document 5 describes a prosthetic tooth stabilizer containing a lower alkyl vinyl ether / maleic anhydride copolymer or a derivative thereof, as well as a water-insoluble and water-swellable polymer, and an adhesive substance such as a natural rubber or a synthetic polymer. Is disclosed.

US Patent Gazette No. 3,003,988 US Patent Gazette No. 4,373,036 US Patent Gazette No. 5,006,571 Special Table No. 10-506928 Gazette JP-A-2007-186510

As described above, various denture stabilizers having excellent adhesiveness and adhesive stability in the presence of water and capable of stably immobilizing the denture in the oral cavity have been proposed, but there are still many points to be improved. The reality is that there is.

Therefore, a main object of the present invention is to provide a denture stabilizer which is excellent in adhesiveness and adhesive stability in the presence of water and which is further improved so that the denture can be stably immobilized in the oral cavity. It is to be.

The present inventors have focused on lower alkyl vinyl ether / maleic anhydride copolymers, derivatives thereof, or salts thereof as adhesive components in order to improve the adhesiveness and adhesive stability of denture stabilizers, which is a conventional problem. As a result of examination, the above-mentioned objectives can be achieved by using a hydrogen phosphate salt in combination with the lower alkyl vinyl ether / maleic anhydride copolymer, specifically, by using a hydrogen phosphate salt in combination. We have found that the adhesiveness and adhesive stability (adhesive persistence) of derivatives or their salts in the presence of water are further enhanced (improved), and are actually used as denture stabilizers for mounting and fixing dentures in the oral cavity. It was confirmed that the usability was improved.

The present invention has been completed as a result of further research based on these findings, and includes the following embodiments.

(I) Denture Stabilizer (I-1) A denture stabilizer containing the following components (A) and (B):
(A) At least one adhesive component (B) hydrogen phosphate selected from the group consisting of lower alkyl vinyl ether / maleic anhydride copolymers, derivatives thereof, and salts thereof.
(I-2) At least one of the hydrogen phosphate salts selected from the group consisting of sodium dihydrogen phosphate, disodium hydrogen phosphate, potassium dihydrogen phosphate, dipotassium hydrogen phosphate, and calcium hydrogen phosphate. The artificial tooth stabilizer according to (I-1).
(I-3) The denture stabilizer according to (I-1) or (I-2), wherein the ratio of the component (B) to 100 parts by weight of the component (A) is 0.5 to 40 parts by weight.
(I-4) Described in any one of (I-1) to (I-3), wherein the component (A) is contained in an amount of 10 to 60% by weight and the component (B) is contained in a proportion of 0.15 to 12% by weight. Denture stabilizer.
(I-5) The denture stabilizer according to any one of (I-1) to (I-4), which further contains a water-soluble polymer as an adhesive auxiliary component.

(II) Method for enhancing the adhesive strength of the denture stabilizer (II-1) (A) At least one adhesive selected from the group consisting of a lower alkyl vinyl ether / maleic anhydride copolymer, a derivative thereof, and a salt thereof. A method for enhancing the adhesive strength of a denture stabilizer, which comprises blending (B) a hydrogen phosphate salt with a denture stabilizer composition containing an ingredient.
(II-2) At least one of the hydrogen phosphate salts selected from the group consisting of sodium dihydrogen phosphate, disodium hydrogen phosphate, potassium dihydrogen phosphate, dipotassium hydrogen phosphate, and calcium hydrogen phosphate. The enhancement method according to (II-1).
(II-3) The enhancement method according to (II-1) or (II-2), wherein the ratio of the component (B) to 100 parts by weight of the component (A) is 0.5 to 40 parts by weight.
(II-4) In the target denture stabilizer composition, the ratio of the component (A) in 100% by weight of the denture stabilizer after blending the component (B) is 10 to 60% by weight. , The enhancement method according to any one of (II-1) to (II-3), which contains the component (A).

The denture stabilizer of the present invention comprises at least one adhesive component selected from the group consisting of (A) lower alkyl vinyl ether / maleic anhydride copolymer, derivatives thereof, and salts thereof, and (B) hydrogen phosphate. By including in combination with, the adhesiveness and adhesive stability (adhesive persistence) of the component (A) in the presence of water are further enhanced (improved), and as a result, this is used as a denture stabilizer in the oral cavity. When used for fixing the denture on the denture, a good denture wearing and using feeling can be obtained.

Further, according to the method for enhancing the adhesiveness of a denture stabilizer of the present invention, at least one adhesive component selected from the group consisting of (A) a lower alkyl vinyl ether / maleic anhydride copolymer, a derivative thereof, and a salt thereof. The adhesiveness in the presence of water, preferably the adhesive stability (adhesive persistence) of the substance, can be further enhanced (improved) by using (B) a hydrogen phosphate salt in combination. Therefore, by utilizing this method for the preparation of the denture stabilizer, it is possible to obtain a denture stabilizer capable of stably mounting and fixing the denture in the oral cavity and obtaining a good denture wearing feeling.

(I) Denture Stabilizer A denture stabilizer is a preparation used to attach and immobilize a denture on the ridge (gingiva) or maxilla by bringing the denture into close contact with the ridge (gingiva) or maxilla. be. Also called a denture adhesive. The dentures of interest are usually complete dentures and partial dentures.

The form of the denture stabilizer targeted by the present invention is not particularly limited, and is in the form of a paste such as cream type or gel type, a powder form such as powder type, or a sheet (tape) form such as tape type or sheet type. Includes denture stabilizers having various forms of. Further, the material of the target denture floor is not limited, and it can be applied to both a resin floor and a metal floor.

The denture stabilizer of the present invention is characterized by containing the following components (A) and (B).
(A) At least one adhesive component selected from the group consisting of lower alkyl vinyl ether / maleic anhydride copolymers, derivatives thereof, and salts thereof.
(B) Hydrogen phosphate.

Here, the hydrogen phosphate salt which is the component (B) is a component whose adhesiveness (and adhesive stability) can be enhanced by using it in combination with the adhesive component of (A). Therefore, the component (B) can be positioned as an adhesive (and adhesive stability) enhancing component of the adhesive component (A).

Hereinafter, these components and other components that can constitute a denture stabilizer will be described.

(1) (A) Adhesive Component A lower alkyl vinyl ether / maleic anhydride copolymer used as the (A) adhesive component in the present invention, a derivative thereof or a salt thereof (hereinafter, these are referred to as "AVE / MA copolymers"). (Sometimes referred to as) has the property of absorbing water, slowly dissolving, and exhibiting stickiness.

Here, the lower alkyl vinyl ether / maleic anhydride copolymer is a copolymer produced by polymerizing a lower alkyl vinyl ether monomer and maleic anhydride. The copolymer can be easily hydrolyzed to an acid polymer.

In the lower alkyl vinyl ether / maleic anhydride copolymer and the lower alkyl vinyl ether monomer as a material thereof, the "lower alkyl group" usually includes an alkyl group having 1 to 8 carbon atoms. An alkyl group having 1 to 6 carbon atoms is preferable, and an alkyl group having 1 to 4 carbon atoms is more preferable. Specifically, a methyl group, an ethyl group, an n-propyl group, an isopropyl group, an n-butyl group, an isobutyl group, a t-butyl group, a sec-butyl group and the like can be exemplified. Therefore, as the lower alkyl vinyl ether / maleic anhydride copolymer, specifically, methyl vinyl ether / maleic anhydride copolymer, ethyl vinyl ether / maleic anhydride copolymer, divinyl ether / maleic anhydride copolymer, Examples thereof include a propyl vinyl ether / maleic anhydride copolymer and an isobutyl vinyl ether / maleic anhydride copolymer.

The derivative of the lower alkyl vinyl ether / maleic anhydride copolymer was obtained by polymerizing a lower alkyl vinyl ether monomer and a maleic anhydride derivative, or by copolymerizing a lower alkyl vinyl ether with maleic anhydride. It can be produced by inducing an alkyl vinyl ether-maleic anhydride copolymer.

Here, as the lower alkyl group in the lower alkyl vinyl ether, as described above, an alkyl group having 1 to 8 carbon atoms, preferably 1 to 6 carbon atoms, and more preferably 1 to 4 carbon atoms can be similarly mentioned. can.

Examples of the maleic anhydride derivative include maleic acid and a maleic acid semi-ester. Here, as the maleic acid semi-ester, esters of alcohols usually having 1 to 18 carbon atoms, preferably 1 to 10 carbon atoms, more preferably 1 to 8 carbon atoms, and particularly preferably 1 to 6 carbon atoms are preferable. It can be exemplified.

Derivatives of the lower alkyl vinyl ether / maleic anhydride copolymer can be obtained by hydrolyzing, esterifying, or reacting the alkyl vinyl ether / maleic anhydride copolymer with a metal compound by a known method.

For example, in the hydrolysis of the lower alkyl vinyl ether / maleic anhydride copolymer, 1 to 70 parts by weight, preferably 10 parts by weight of the lower alkyl vinyl ether / maleic anhydride copolymer is added to 100 parts by weight of water heated to 90 to 95 ° C. A lower alkyl vinyl ether / maleic anhydride copolymer can be obtained by adding ~ 50 parts by weight. Further, in order to esterify the alkyl vinyl ether / maleic anhydride copolymer, alcohol is used as a reaction solvent (a calculated amount of alcohol that becomes a 10 to 20% solution of the semiester), and the reflux temperature of the alcohol is several hours to 10 hours. Alcohol vinyl ether / maleic acid semi-ester can be obtained by reacting for several hours. Further, the method described in Japanese Patent Publication No. 43-25982, that is, a method of reacting a powdery maleic anhydride / vinyl compound copolymer with an alcohol in a gaseous state to obtain a semiester of the copolymer in the form of powder. Can also be adopted. As a method for producing a copolymer of alkyl vinyl ether and maleate, a known method for producing a salt of carboxylic acid can be used.

Although not limited, the lower alkyl vinyl ether / maleic anhydride copolymer and its derivatives in the present invention preferably have a weight average molecular weight of 200,000 to 2.4 million. More preferably, it has a weight average molecular weight of 1 million to 2 million.

Examples of the salt of the lower alkyl vinyl ether / maleic anhydride copolymer or a derivative thereof include monovalent, divalent and trivalent cations. Specific examples thereof include alkali metal salts such as potassium salts and sodium salts, alkaline earth metal salts such as calcium salts and magnesium salts, zinc salts, and strontium salts. Sodium salt and calcium salt are preferable. These salts may be used alone or in combination of the two. The mode of combination is not particularly limited, and examples thereof include a mixed salt containing both a sodium salt and a calcium salt, a mixed salt containing both a zinc salt and a magnesium salt, and a mixed salt containing both a zinc salt and a strontium salt. A combination of a sodium salt and a calcium salt is preferable.

Such lower alkyl vinyl ether / maleic anhydride copolymers, derivatives thereof and salts thereof are referred to as Gantrez (registered trademark, the same shall apply hereinafter) from ISP Japan (International Specialty Products of Wayne, New Jersey, USA). It can be obtained commercially under the product name. Specifically, the lower alkyl vinyl ether / maleic anhydride copolymer is available as the Gantrez AN series, and the lower alkyl vinyl ether / maleic acid copolymer is available as the Gantrez S series. Further, as a salt of a lower alkyl vinyl ether / maleic anhydride copolymer or a derivative thereof, Gantrez MS-955 can be used as a salt containing both a sodium salt and a calcium salt. The weight average molecular weight of Gantrez MS is about 1 million, and its Brookfield viscosity (mPa. S (11.1% solids aq.)) Is 700 to 3000.

In the present invention, as the (A) adhesive component, the lower alkyl vinyl ether / maleic anhydride copolymer, its derivative or a salt thereof may be used alone or in combination of two or more. You may use it.

The total amount of the adhesive component (A) contained in 100% by weight of the denture stabilizer of the present invention is usually 10 to 60% by weight, preferably 20 to 50% by weight, and more preferably 25 to 35% by weight. Can be mentioned. This ratio is included in the product when the total weight of the final product (weight excluding the support in the case of a form having a support such as a sheet type) is 100% by weight regardless of the form of the final product. (A) means the ratio (% by weight) of the adhesive component. Hereinafter, the same applies to the blending ratio (% by weight) of (B) hydrogen phosphate, water-soluble polymer, oil-based base and the like.

(2) (B) Bicarbonate of Phosphate As described above, the bicarbonate of (B) component can be used in combination with the adhesive component (AVE / MA copolymers) of (A) to make it sticky. It is a component that can enhance the property (and adhesive stability).

The hydrogen phosphate salt used in the present invention is not particularly limited as long as it has such characteristics. Specific examples thereof include sodium dihydrogen phosphate, disodium hydrogen phosphate, potassium dihydrogen phosphate, dipotassium hydrogen phosphate, and calcium hydrogen phosphate. These hydrogen phosphate salts may be used alone or in combination of two or more as long as they exhibit the above characteristics. Preferred hydrogen phosphate salts are disodium hydrogen phosphate and sodium dihydrogen phosphate, more preferably disodium hydrogen phosphate.

As the ratio of (B) bicarbonate to 100 parts by weight of (A) adhesive component contained in the denture stabilizer of the present invention, the effect of the present invention can be exhibited by exhibiting the above-mentioned characteristics of (B) bicarbonate. It may be in the range of playing, and for example, the range of 0.5 to 40 parts by weight can be mentioned. It is preferably 1 to 20 parts by weight, more preferably 1 to 10 parts by weight. The total amount of the above-mentioned hydrogen phosphate (B) contained in 100% by weight of the denture stabilizer of the present invention is usually 0.15 to 12% by weight, preferably 0.3 to 6% by weight. Preferably, 0.3 to 3% by weight can be mentioned.

(3) Other Components The denture stabilizer of the present invention may contain a water-soluble polymer in addition to the above components (A) and (B) as long as the effects of the present invention are not impaired.

As a water-soluble polymer, together with the AVE / MA copolymer used as the component (A), it absorbs water in the oral cavity and exerts an appropriate adhesive force, which contributes to the fixation and stabilization of the denture in the oral cavity. Those can be preferably mentioned. In this sense, the water-soluble polymer can be positioned as an adhesive auxiliary component. Examples of the water-soluble polymer include alginic acid, alginates (for example, sodium alginate, potassium alginate, ammonium alginate, alginate ester, etc.), and gum arabic. , Tragant gum, locust bean gum, xanthan gum, gua gum, agar, gelatin, karaya gum, carrageenan and other natural polymer compounds; sodium carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, hydroxypropyl cellulose (above, cellulose-based polymer), polyethylene glycol , Polyvinylpyrrolidone, polyvinyl alcohol, methyl vinyl ether, carboxyvinyl polymer, copolymer of acrylamide and alginic acid, synthetic polymer compounds such as sodium polyacrylate and polyethylene oxide. These water-soluble polymers may be used alone or in combination of two or more.

Preferably, it swells when it contains water and exhibits stickiness and / or elasticity. Examples thereof include alginate, karaya gum, polyethylene oxide and sodium carboxymethyl cellulose. More preferably, alginate (eg, sodium alginate) and sodium carboxymethyl cellulose, and particularly preferably sodium carboxymethyl cellulose.

When a water-soluble polymer is used, the total amount of the water-soluble polymer to be blended in 100% by weight of the denture stabilizer of the present invention is usually 10 to 60% by weight, preferably 20 to 40% by weight. Preferably, 20 to 30% by weight can be mentioned. The ratio of the (A) adhesive component (AVE / MA copolymers) contained in the denture stabilizer to 100 parts by weight is not limited, but the total amount is usually 10 to 200 parts by weight, preferably 50 to 150 parts by weight. , More preferably 80 to 120 parts by weight.

Further, the artificial tooth stabilizer of the present invention has an oil-based base, an aqueous base, a powder base, a gum base, and an excipient, depending on its form and properties, as long as the effects of the present invention are not impaired. , Emulsifiers, wetting agents, pH adjusting agents, viscosity adjusting agents, plasticizers, preservatives, bactericides, pigments, fragrances, flavoring agents, cooling agents, sweeteners and the like can be blended. As such carriers and additives, those conventionally widely used as denture stabilizers can be similarly used.

For example, an oil-based base is used as a base when preparing a denture stabilizer in a paste-like form such as a cream type.

Examples of the oil-based base include mineral oil components usually used in non-aqueous denture stabilizers (for example, cream type). For example, liquid paraffin, vaseline, gelled hydrocarbon and the like can be mentioned.

Specific examples of liquid paraffin include light liquid paraffin and heavy liquid paraffin. It is preferably a light liquid paraffin having an average carbon number of 15 to 50, more preferably 25 to 50. As the petrolatum, any petrolatum usually used as an external base can be used, and examples thereof include yellow petrolatum, white petrolatum, and a mixture thereof. Further, let's expose to white petrolatum, stearyl alcohol, or hydrophilic petrolatum containing cholesterol can be used. White petrolatum is preferable. As the gelled hydrocarbon, for example, polyethylene is blended in a ratio of 5 to 10 parts by weight, preferably 5.5 to 7.5 parts by weight with respect to 100 parts by weight of liquid paraffin, and the temperature at which polyethylene melts (110 to 130). A gel-like product prepared by heating and mixing at (° C.) can be mentioned. One of these mineral oil components may be used alone as an oil-based base, or two or more of these mineral oil components may be arbitrarily combined and used as an oil-based base.

The proportion (total amount) of the oily base used in the cream-type denture stabilizer is usually 10 to 70% by weight, preferably 20 to 60% by weight, more preferably 30 to 50% by weight in 100% by weight of the denture stabilizer. The range of% can be mentioned.

Aqueous bases are usually used as the base when preparing an aqueous denture stabilizer (eg, gel type). Examples of the aqueous base include water, glycerin, propylene glycol and the like.

On the other hand, when a water-soluble polymer is mainly used as a base for preparing a powder-type denture stabilizer, but an excipient such as lactose or starch and a solvent such as ethanol are used for granulation. There is also.

The denture stabilizer of the present invention can be prepared according to the conventional technique in the art according to its form (cream type, gel type, powder type, sheet (tape) type, etc.).

The method of using the denture stabilizer of the present invention can also be appropriately selected according to its form (cream type, gel type, powder type, sheet (tape) type, etc.). For example, a paste-like denture stabilizer such as a cream type is used by applying and adhering it to the entire surface of the denture base (base of dentures) from which water has been removed and in contact with the gingiva (or maxilla) while spreading it thinly. In addition, powdered denture stabilizers such as powder type are evenly and thinly sprinkled on the entire surface of the denture base (base of dentures) in contact with the gums (or upper jaw) with a little water attached to shake off excess powder. It is used for. Further, a sheet (tape) type denture stabilizer is used by sticking and adhering to the surface of the denture base (base of dentures) from which water has been removed and in contact with the gingiva (or maxilla). When the denture to which the denture stabilizer is attached is placed in the oral cavity and attached to the gum (or maxilla), the denture stabilizer absorbs saliva and swells to exert adhesiveness, and the denture (or upper jaw) becomes sticky. Or it is stably fixed to the upper jaw).

(II) Method for Enhancing Adhesive Strength of Denture Stabilizer The present invention relates to a method for enhancing the adhesive strength of a denture stabilizer. More specifically, it is a method for enhancing the adhesive strength of a denture stabilizer (however, not containing hydrogen phosphate) containing the above-mentioned adhesive component (AVE / MA copolymers) of (A). The method is characterized in that (A) an adhesive component is used in combination with (B) a hydrogen phosphate salt.

The adhesive component (AVE / MA copolymers) of (A) and the (B) hydrogen phosphate salt blended in combination with the adhesive component (AVE / MA copolymers) have already been described in (I), and the above (I) is here. The explanation of is used.

The target denture stabilizer composition for enhancing the adhesive strength is (B) the adhesive component (AVE / MA copolymers) in the denture stabilizer (final denture stabilizer) after blending the hydrogen phosphate. ) Is usually 10 to 60% by weight, preferably 20 to 50% by weight, and (A) the adhesive component (AVE / MA copolymers) is preferably contained. More preferably, the proportion of the (A) adhesive component (AVE / MA copolymer) in the final denture stabilizer is 25 to 35% by weight, and the proportion of the (A) adhesive component (AVE / MA copolymer) is 25 to 35% by weight. ) Is contained.

The blending ratio of the (B) hydrogen phosphate salt to the denture stabilizer composition may be as long as the effect of the present invention is exhibited, and is not particularly limited, but is included in the denture stabilizer composition. (A) Usually, 0.5 to 40 parts by weight can be mentioned with respect to 100 parts by weight of the total amount of the adhesive component. It is preferably 1 to 20 parts by weight, more preferably 1 to 10 parts by weight. Further, the ratio of (B) bicarbonate in 100% by weight of the final denture stabilizer (final denture stabilizer) containing (A) adhesive component and (B) bicarbonate is 0.15-12. It is preferable to add (B) hydrogen phosphate so as to be by weight%. It is more preferably 0.3 to 6% by weight, still more preferably 0.3 to 3% by weight.

The denture stabilizer thus prepared is a denture stabilizer that does not contain (B) hydrogen phosphate, that is, (A) an adhesive component (AVE / MA copolymers) in combination with (B) hydrogen phosphate. Compared to denture stabilizers prepared without denture stabilizers (control denture stabilizers), the adhesiveness in the presence of water is more enhanced. Therefore, the denture stabilizer prepared by using the method of the present invention has an effect of being excellent in adhesiveness in the oral cavity. Further, as shown in Test Example 3 described later, according to the method, (B) adhesion in the presence of water (intraoral cavity) as compared with a control denture stabilizer prepared without using a hydrogen phosphate salt in combination. The stability is more enhanced. Therefore, the denture stabilizer prepared by using the method of the present invention has an effect that the adhesive stability in the oral cavity is excellent and the adhesive strength is also good.

Hereinafter, the configuration and effect of the present invention will be described based on Test Examples and Examples. However, the present invention is not limited to such test examples and examples. Unless otherwise specified, the% described below shall mean "% by weight".

Test Example 1 Evaluation of Viscosity Effect A solution prepared by adding a mixture of (A) adhesive component and (B) hydrogen phosphate prepared at the ratio shown in Tables 1 and 2 into water and stirring and dissolving (Examples 1 to 5). , And Examples 6 to 9) (25 ° C.) were measured using a B-type viscometer (manufactured by Brookfield) (rotor No. 2 to 4) under the conditions of a rotation speed of 5 rpm and a measurement time of 1 minute. did. As a comparative test, the adhesive component (A) was added to water at the ratios shown in Table 3, and the viscosities of the solutions (Comparative Examples 1 to 3) (25 ° C.) dissolved by stirring were measured under the same conditions as above. The results are shown in Tables 1 to 3, respectively.

Here, methoxyethylene / maleic anhydride copolymer sodium / calcium salt (Gantrez MS-955, manufactured by ASP Japan) was used as the adhesive component. In Table 1, this is referred to as "AME / MA copolymers".

As shown in the table, from the comparison between the viscosity of Example 1 and the viscosity of Comparative Example 1, by using a hydrogen phosphate salt in combination with the adhesive component (AME / MA copolymers, the same applies hereinafter), it depends on the adhesive component. It can be seen that the viscosity increases. The thickening effect of the combined use of the hydrogen phosphate salt is also shown by the comparison between Examples 2 to 4 and 6 to 9 and Comparative Example 2, and the comparison between Example 5 and Comparative Example 3. Further, from the viscosities of Examples 2 to 4, it can be seen that the thickening effect of the combined use of the hydrogen phosphate salt increases as the ratio of the hydrogen phosphate salt to the adhesive component (AME / MA copolymers) increases. ..

Test Example 2 Evaluation of Viscosity and Adhesive Strength (1) Preparation of Test Sample A cream-type denture stabilizer composition (Examples 10 to 12 and Comparative Example 4) was prepared according to the formulation shown in Table 4. Specifically, after heating and mixing mineral oil components (light liquid paraffin, petrolatum), a sticky component, hydrogen phosphate (disodium hydrogen phosphate), and water-soluble polymer (sodium carboxymethyl cellulose) are added. Prepared by mixing uniformly. Here, methoxyethylene / maleic anhydride copolymer sodium / calcium salt (Gantrez MS-955, manufactured by ASP Japan) was used as the adhesive component. In Table 2, this is referred to as "AME / MA copolymers".

(2) Measurement of Viscosity 20 times the amount (weight ratio) of water is added to a container containing the denture stabilizer (Examples 10 to 12 and Comparative Example 4) prepared in (1) above, and the mixture is kneaded and dissolved to have a viscosity. A solution for measurement was prepared. The viscosity of the solution (25 ° C.) was measured using a B-type viscometer (manufactured by Brookfield Co., Ltd.) (Rotor No. 3) under the conditions of a rotation speed of 50 rpm and a measurement time of 1 minute. The results are shown in Table 4.

(3) Measurement of Adhesive Strength Add 4 times the amount (weight ratio) of water to the container containing the denture stabilizer (Examples 10 to 12 and Comparative Example 4) prepared in (1) above, and knead and dissolve. A sample for measuring adhesive strength was prepared. The adhesive strength of this sample was measured using a rheometer (CR-500DX, manufactured by Sun Scientific Co., Ltd.) by the method described below.
(A) 15 g of the sample was placed in a glass flat-bottomed beaker having a capacity of 10 mL, and the surface was flattened.
(B) A resin adapter having a diameter of 15 mm was inserted at a speed of 50 mm / min to a depth of 10 mm from the sample surface.
(C) Immediately after insertion, the adapter was retracted at a speed of 50 mm / min, and at that time, the maximum load (g weight) related to the adapter was measured, and the adhesive force (kPa) was calculated according to the following formula.

The results are also shown in Table 4.

From this result, it can be seen that when (a) the adhesive component (AME / MA copolymers) is used in combination with (b) the hydrogen phosphate salt, the adhesiveness increases with the viscosity. It can also be seen that the degree of increase increases as the proportion of (a) the hydrogen phosphate to the adhesive component increases.

Test Example 3 Evaluation of wearing feeling The denture stabilizer (Examples 10 to 12, Comparative Example 4) prepared in Test Example 2 was targeted at 6 panelists, and the wearing feeling (wearing stability and its sustainability) was obtained. Was evaluated. Specifically, we asked six complete denture users (with a history of use of 3 years or more) to wear complete dentures using each denture stabilizer, and felt that the dentures were stably adhered to the gums. We asked them to measure each time and score according to the following criteria.

For each denture stabilizer, apply an amount equivalent to 4 soybeans (total amount 2 g) to the surface of the base of the denture (for maxilla and mandible) in contact with the gums, and apply it thinly over the entire surface. I stretched it out and had it put on in the oral cavity. In addition, each panelist was asked to evaluate the wearing feeling of each of the four types of denture stabilizers on different test dates based on the same criteria.
[Evaluation criteria]
Time when the denture felt stable and adhered Over 10 hours: 10 points 5 to 10 hours or less: 3 points 0 to 5 hours or less: 1 point.

Table 5 shows the result of averaging the scores evaluated by each panelist.

As shown in Table 5, by using (a) adhesive components (AME / MA copolymers) in combination with (b) hydrogen phosphate, adhesive stability (adhesive persistence) when actually placed in the oral cavity It can be seen that sex) also increases. In addition, this result correlates with the effect of increasing the adhesive strength evaluated in Test Example 2. By using a hydrogen phosphate salt in combination with the adhesive component (AME / MA copolymers), the adhesive strength and the adhesive stability It can be seen that (adhesive persistence) is also improved (increased), and the degree of increase increases as (a) the proportion of (b) hydrogen phosphate to the adhesive component increases.

Formulation Examples Cream-type, gel-type, powder-type, and sheet-type denture stabilizers can be produced according to the formulations shown below. The "AME / MA copolymers" shown below include methoxyethylene / maleic anhydride copolymer sodium / calcium salt (Gantrez MS-955) and methoxyethylene / maleic anhydride copolymer (Gantrez AN-169). , Gantrez AN-179) can be used.

Formulation Example 1 Cream-type denture stabilizer The following ingredients are mixed while heating to prepare a cream-type denture stabilizer.
AME / MA copolymers 30 (% by weight)
Disodium hydrogen phosphate 1.5
Carboxymethyl cellulose Na 25
Liquid paraffin 15
Vaseline 28.5
Total 100.0% by weight.

Formulation Example 2 Gel-type denture stabilizer A gel-type denture stabilizer is prepared by mixing and dissolving the following raw materials while heating.
AME / MA copolymers 20 (% by weight)
Disodium hydrogen phosphate 1
Carboxymethyl cellulose Na 10
Propylparaben 0.05
Water 68.95
Total 100.00% by weight.

Formulation Example 3 Powder or granular type denture stabilizer A granular denture stabilizer is prepared by mixing the following raw materials into a powder or further granulating by a conventional method.
AME / MA copolymers 60 (% by weight)
Disodium hydrogen phosphate 3
Carboxymethyl cellulose Na 37
Total 100% by weight.

Prescription Example 4 Sheet-type denture stabilizer The following raw materials are mixed to form a powder, or granulated by a conventional method to form granules, which are evenly sprayed on a support such as a non-woven fabric. Further, a similar support is put on it and integrated by thermocompression bonding or needle punching. Next, a sheet-type denture stabilizer is prepared by cutting into a desired shape according to the shape of the denture base.
AME / MA copolymers 60 (% by weight)
Disodium hydrogen phosphate 3
Carboxymethyl cellulose Na 37
Total 100% by weight.

Claims (2)

A denture stabilizer containing the following components (A) and (B) and having a ratio of the component (B) to 100 parts by weight of the component (A) of 4 to 20 parts by weight:
(A) At least one adhesive component selected from the group consisting of a lower alkyl vinyl ether / maleic anhydride copolymer, a derivative thereof, and a salt thereof (B) Potassium dihydrogen phosphate, dipotassium hydrogen phosphate, phosphorus At least one hydrogen phosphate selected from the group consisting of sodium dihydrogen acid and calcium hydrogen phosphate ( excluding the following artificial tooth adhesive compositions:
a) An amount of about 20.0% by weight to about 70.0% by weight of the artificial tooth adhesive composition of the artificial tooth adhesive composition, which is a partial salt of a methyl vinyl ether-maleic acid copolymer and sodium carboxymethyl cellulose. A cohesive force-enhancing component in an amount of about 0.001% by weight to about 10% by weight of the artificial tooth adhesive composition, which comprises a mixture, and b) monophosphate and diphosphate. , Or a cohesive adhesive composition comprising at least one of the triphosphates, a cohesive force-enhancing component ;
As a component for improving cohesive force with respect to 16.50 parts by weight of Ca (70) / Na (5) MVE / MA salt (manufactured from AN169BF), which is a partial salt of methyl vinyl ether-maleic acid copolymer as a component of artificial tooth adhesive. A dentifrice adhesive composition containing disodium phosphate in a proportion of 0.50 parts by weight . ). (A) Dipotassium phosphate (B) dipotassium phosphate is added to a dentifrice stabilizer composition containing at least one adhesive component selected from the group consisting of a lower alkyl vinyl ether / maleic anhydride copolymer, a derivative thereof, and a salt thereof. At least one hydrogen phosphate salt selected from the group consisting of potassium, dipotassium hydrogen phosphate, sodium dihydrogen phosphate, and calcium hydrogen phosphate is added in an amount of 4 to 20 parts by weight based on 100 parts by weight of the component (A). A method for enhancing the adhesive strength of the artificial tooth stabilizer composition , which comprises blending in the ratio of (However, the following methods are excluded:
a) A mixture of a partial salt of a methyl vinyl ether-maleic acid copolymer and sodium carboxymethyl cellulose, which is an amount of about 20.0% by weight to about 70.0% by weight of the artificial tooth adhesive composition of the artificial tooth adhesive composition. Including, b) a cohesive force improving component in an amount of about 0.001% by weight to about 10% by weight of the artificial tooth adhesive composition, which is monophosphate, diphosphate, or A method for improving the cohesive force of an artificial tooth adhesive composition, which comprises a cohesive force improving component which is at least one of the triphosphates ;
As a component for improving cohesive force with respect to 16.50 parts by weight of Ca (70) / Na (5) MVE / MA salt (manufactured from AN169BF), which is a partial salt of methyl vinyl ether-maleic acid copolymer as a component of artificial tooth adhesive. A method of blending disodium phosphate in a proportion of 0.50 parts by weight to improve the cohesive force of the artificial tooth adhesive component . ).