JP6920787B2 - Sebum secretion promoter and its use - Google Patents

Description

The present invention relates to a sebum secretion promoter and its use.

Sebum contains triglycerides, wax esters, squalene, free fatty acids and the like. Such sebum is secreted from the sebaceous glands and has actions such as giving flexibility to the skin surface, giving elasticity, and maintaining moisturizing properties. In addition, sebum plays an important role in preventing damage to the skin surface due to ultraviolet rays and the like, and protecting the skin surface from foreign substances such as bacteria.

On the other hand, it is known that the amount of sebum secreted decreases due to various factors such as aging and drug administration. A decrease in the amount of sebum secreted has an adverse effect such as a decrease in the flexibility of the skin surface and a decrease in the resistance of the skin surface to damage, and also causes skin diseases such as dry skin surface and sebum deficiency eczema. It also becomes. Therefore, it is important to promote sebum secretion.

So far, it has been reported that the extract of Maitake mushroom promotes the secretion of sebum (Patent Document 1).

International Publication No. 2007/142130

An object of the present invention is to provide a sebum secretion-promoting agent capable of effectively promoting sebum secretion, a composition containing the sebum secretion-promoting agent, and the like.

As a result of intensive research conducted by the present inventor in view of the above problems, by using the extract of Senkyu, the extract of Clara, the extract of Fukitanpopo, the extract of Fuyubodaiju, the extract of Bukuryo, and the extract of lavender, It was found that the secretion of sebum can be improved. The present invention has been completed as a result of further studies based on the findings, and is as follows.
Item 1. A sebum secretagogue containing at least one extract selected from the group consisting of Senkyu, Clara, Coltsfoot, Tilia cordata, Bukuryo and lavender.
Item 2. An external composition for promoting sebum secretion, which contains the sebum secretion promoting agent according to Item 1.
Item 3. The above-mentioned composition contains 0.0001 to 20% by weight of a dry extract of at least one extract selected from the group consisting of Senkyu, Clara, Coltsfoot, Tilia cordata, Bukuryo and Lavender. 2. The external composition for promoting sebum secretion according to 2.

According to the present invention, the secretion of sebum can be promoted. Therefore, according to the present invention, it is possible to improve the skin symptoms associated with the decrease in sebum secretion.

FIG. 1 shows that the extract caused the growth of lipid droplets in sebaceous gland cells and promoted the secretion of sebum.

Sebum Secretagogue The present invention provides a sebum secretagogue containing at least one extract selected from the group consisting of Senkyu, Clara, Coltsfoot, Tilia cordata, Bukuryo and Lavender.

The raw materials for the extract contained as an active ingredient in the sebum secretion promoter of the present invention include Cnidium officinale, Sophora flavescens, Coltsfoot farfara, Tilia cordata, and Poria cocos. ), Lavandula.

For these plants, the site of use is not particularly limited, but preferably, the rhizome of Senkyu, the root of Clara excluding the periderm of the root, the flower of Tilia cordata, the leaves and flowers of Tilia cordata, and the outer layer of Bukuryo are removed. Examples include rhizomes and lavender flowers.

As the active ingredient of the sebum secretion promoter of the present invention, the extract may be used alone or in combination of two or more. When two or more kinds of the extracts are used in combination, these combinations are not particularly limited, and the site of use thereof is not particularly limited.

In addition, the plant is not limited to this extent, and the plant is often referred to in various ways. For example, Clara may be described as Kujin, Sophora flavescens var. Angustifolia, Sophora Angustifolia, etc. Tilia cordata is sometimes referred to as linden or the like, and the present invention includes such names.

The production method (extraction method), extraction conditions, and the like of the extract are not particularly limited, and conventionally known methods may be followed. For example, each part of the plant (whole plant, flower, fruit, leaf, branch, bark, rhizome, root, root without periderm, seed, seed coat, sclerotium, etc.) is cut as it is as needed. After crushing or drying, the extract can be obtained by exploitation or solvent extraction. As the solvent extraction method, a method known in the art may be adopted, and conventionally known extraction methods such as water (including hot water and hot water) extraction, alcohol extraction, supercritical extraction and the like can be used. ..

When solvent extraction is performed, the solvent is, for example, water; lower alcohols such as methanol and ethanol, and alcohols such as polyhydric alcohols such as propylene glycol and 1,3-butylene glycol (whether anhydrous or water-containing); Examples thereof include ketones such as acetone, esters such as diethyl ether, dioxane, acetonitrile and ethyl acetate, xylene, benzene, chloroform and the like, and the extract thus obtained can be particularly referred to as a solvent extract. .. The solvent is preferably water, lower alcohol, 1,3-butylene glycol or the like (water extract, lower alcohol extract, 1,3-butylene glycol extract or the like), and more preferably ethanol (ethanol extract), 1 , 3-Butylene glycol (1,3-butylene glycol extract), more preferably hydrous ethanol (hydrous ethanol extract). These solvents may be used alone or in combination of two or more.

The obtained extract may be used as it is, or may be dried and used in a solid state such as powder or granules. Further, if necessary, the obtained extract may be subjected to purification, concentration treatment, separation treatment of highly active fractions and the like. Although not limiting the present invention, as the purification treatment, treatments such as filtration or adsorption and decolorization using an ion exchange resin or an activated carbon column can be used. Further, as the concentration treatment, a conventional method such as an evaporator can be used. Further, as the separation treatment of the highly active fraction, known separation treatments such as gel filtration, adsorption treatment, silica gel column chromatography, and HPLC (High performance liquid chromatography) can be used.

Further, for example, a method of pulverizing the obtained extract (or purified product, concentrated product, highly active fraction) by subjecting it to freeze-drying treatment, and if necessary, addition of dextrin, cornstarch, Arabic rubber, etc. The extract may be used in the present invention by adding a shaping agent and pulverizing according to a conventionally known method such as a method of pulverizing by spray-drying. Further, the extract may be used by dissolving it in pure water, ethanol or the like, if necessary.

The extract of the plant is preferably an extract obtained by drying, crushing and / or cutting the plant as a raw material, extracting and filtering using a suitable solvent, and an extract thus obtained. An example is an extract obtained by further drying the mixture.

In the present invention, the extract obtained through solvent extraction in this way can be particularly referred to as a solvent extract. Further, although not limiting the present invention, as described above, for example, when water is used as a solvent, a water extract is used, when lower alcohols are used, a lower alcohol extract is used, and when ethanol is used, an ethanol extract is used. It can be called a thing or the like.

Although not limiting the present invention, as an example, an extract can be obtained as follows. In addition, as another example, the extract can be obtained according to the procedure of Examples described later. Further, the extract used in the present invention may be a commercially available product, or may be a commercially available product that has been further subjected to a treatment such as drying.

In the present invention, the extract is obtained by immersing the plant in 100 g per 100 g, preferably a dried product, a crushed product and / or a cut product of the plant in 1 to 50 liters of an extraction solvent at an arbitrary temperature (for example, 15 to 15 to 15 to 50 liters). It can be obtained by extracting at 90 ° C.) for any time (eg, 10 minutes to 24 hours) with stirring as needed, and then filtering.

Although not limiting the present invention, a specific example when hydrous ethanol is used as the extraction solvent will be given below. In the present invention, not only hydrous ethanol but also the above-mentioned extraction solvent can be used in the same manner.

The extract of senkyu is a hydrous ethanol (for example, preferably 5 to 99.5% by volume ethanol, more preferably 30 to 99.5) per 100 g of senkyu (preferably dried and chopped, more preferably rhizome). It can be obtained by immersing in 1 to 50 liters of% ethanol), extracting at room temperature (15 ° C.) to 80 ° C. for 10 minutes to 24 hours with stirring as necessary, and then filtering. ..

The Clara extract is a hydrous ethanol (eg, preferably 5-99.5% by volume ethanol, more preferably 30-99) per 100 g of Clara (preferably dried and chopped, more preferably Clara root). It can be obtained by immersing in 1 to 50 liters of (5.5% by volume ethanol), extracting at room temperature to 80 ° C. for 10 minutes to 24 hours with stirring as necessary, and then filtering.

The same can be said for the extract of Tilia cordata, the extract of Tilia cordata, the extract of Bukuryo, and the extract of lavender. Tilia cordata (preferably dried and shredded, more preferably leaves or flowers), Bukuryo (preferably dried and shredded, more preferably mycelia with most of the outer layer removed) ), Or lavender (preferably dried and shredded, more preferably flowers) per 100 g, hydrous ethanol (eg preferably 5-99.5% by volume ethanol, more preferably 30-99. It can be obtained by immersing in 1 to 50 liters of 5% by volume ethanol), extracting at room temperature to 80 ° C. for 10 minutes to 24 hours with stirring as necessary, and then filtering.

As described above, these may be used alone or in combination of two or more.

The content of the extract in the sebum secretion promoter of the present invention is not limited as long as the effect of the present invention is obtained. Although not limiting the present invention, in the sebum secretion promoter, for example, the extract is 0.001 to 100% by weight, preferably 0.01 to 70% by weight, more preferably in terms of dry matter of the extract. 0.1 to 50% by weight is exemplified. When two or more kinds of the extracts are used, the total amount satisfies the value. The dried extract is obtained by freeze-drying the extract. The freeze-drying treatment is carried out by concentration under reduced pressure using a general evaporator and freeze-drying in a vacuum state.

The preservative of the present invention may contain only the above-mentioned extract, but in addition to the above-mentioned extract, if necessary, a solvent (water, methanol, ethanol, etc.) is used as long as the effect of the present invention is not impaired. Lower alcohols, alcohols such as polyhydric alcohols such as propylene glycol, 1,3-butylene glycol (whether anhydrous or water-containing), excipients, stabilizers, preservatives, thickeners, etc. Emulsifiers, surfactants, binders, lubricants, absorption promoters, oils, antioxidants, anti-inflammatory agents, refreshing agents, moisturizers, chelating agents, film-forming agents, pH adjusters, solubilizers, fragrances, It may contain any component such as a colorant. These may be used individually by 1 type, and may be used in combination of 2 or more type.

Further, the form of the sebaceous secretion promoter of the present invention is not limited, and liquid, paste, mousse, milky liquid, suspension, cream, ointment, gel, solid (powder, granular, etc.) can be used. Included), sheet-like, aerosol-like, spray-like, bubble-like, patch, liniment, capsule and other various desired liquid, semi-solid, solid forms and the like are exemplified. The arbitrary component may be appropriately selected according to the desired form, and by mixing with the extract and, if necessary, any component according to a conventionally known method corresponding to each form. , The sebum secretion promoter of the present invention can be produced.

According to the present invention, sebum secretion can be promoted. In particular, as will be clear from the examples described later, according to the present invention, it is possible to directly act on cells and promote sebum secretion from the sebaceous glands. From this, according to the present invention, various skin symptoms associated with a decrease in sebum secretion can be prevented or ameliorated.
External Composition for Promoting Sebum Secretion The present invention provides an external composition for promoting sebum secretion containing the sebum secretion promoting agent.

The sebum secretion promoter is as described above. The form of the external composition for promoting sebum secretion of the present invention is not limited as long as it is a composition that can be applied to the skin in an external form.

The form is not limited to the present invention, but is liquid, paste, mousse, milky, suspension, cream, ointment, gel, solid (including powder, granular, etc.). , Sheet-like, aerosol-like, spray-like, bubble-like, patch, liniment, capsule and the like, various desired liquid, semi-solid, solid forms and the like are exemplified.

The use of the external composition for promoting sebum secretion of the present invention is not limited to the present invention, but is not limited to the present invention, but is not limited to the present invention. Gel, soap, makeup remover cleansing, body wash, shampoo, rinse, treatment, hair restorer, hair restorer, hair tonic, makeup base, eye cream, foundation, sunscreen, tanning cosmetics, teak, eye shadow, eyeliner, lipstick, Examples include various cosmetics such as gloss, lip balm, and bathing agents, external pharmaceutical products, and external pharmaceuticals. These are prepared according to the usual methods in the art.

In addition to the above-mentioned sebum secretion-promoting agent, the external composition for promoting sebum secretion of the present invention may further contain any other pharmaceutically or cosmetically acceptable component, if necessary. .. Other ingredients include solvents, excipients, stabilizers, preservatives, thickeners, emulsifiers, surfactants, binders, absorption promoters, oils, antioxidants, anti-inflammatory agents, refreshing agents, moisturizers. Agents, whitening agents, antiallergic agents, damage treatment agents, chelating agents, film forming agents, pH adjusters, solubilizers, gelling agents, ointment bases, penetration enhancers, fragrances, coloring agents, amino acids, vitamins, enzymes , Various skin nutrients, UV absorbers, UV scatterers, skin protectants and the like are exemplified. These may be used individually by 1 type, and may be used in combination of 2 or more type. In addition, these may be appropriately selected according to the usual methods in the art according to the various forms and uses. In addition, the external composition for promoting sebum secretion of the present invention can be produced by mixing the extract and, if necessary, any component according to a conventionally known method according to each form.

The content of the sebum secretion-promoting agent in the external composition for promoting sebum secretion of the present invention is not limited as long as the effect of the present invention is exhibited. For example, in the composition, the extract is an extract. 0.0001 to 20% by weight, preferably 0.001 to 10% by weight, in terms of dry matter is exemplified. As described above, the dried extract means the extract that has been freeze-dried.

According to the present invention, by applying the external composition for promoting sebum secretion to the skin, sebum secretion from the sebaceous glands can be promoted. In particular, as will be clear from the examples described later, according to the present invention, it is possible to directly act on cells and promote sebum secretion from the sebaceous glands. From this, according to the present invention, various skin symptoms associated with a decrease in sebum secretion can be prevented or ameliorated.

The external composition for promoting sebum secretion of the present invention is used by applying it to the skin. The amount and number of times the composition is applied are not particularly limited. For example, depending on the type and concentration of the ingredients to be blended, the age, gender, degree of symptoms, application form, expected degree, etc. of the user, an appropriate amount may be applied to the whole body once or several times a day. It may be partially applied to the skin of the skin or the desired skin.

Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited thereto.
1. 1. Preparation of extracts, etc. Extracts, etc. of various plants were prepared according to the following procedure.

Regarding the extract of Senkyu, 100 g of a commercially available Senkyu extract (trade name: Senkyu Extract-JC, manufactured by Maruzen Pharmaceuticals Co., Ltd.) was concentrated under reduced pressure for 30 minutes using an evaporator to remove ethanol, and then frozen in a vacuum state for 15 hours. Drying was carried out to obtain 3.1 g of a solid powder. Next, the extract (powder solid) obtained as described above was dissolved in DMSO (Dimethyl sulfoxide) to a concentration of 10, 100, 200 μg / μL to obtain a Senkyu extract-containing composition.

Regarding Clara extract, 100 g of commercially available Clara extract (trade name: Kujin extract AL-J, manufactured by Maruzen Pharmaceuticals Co., Ltd.) was concentrated under reduced pressure for 30 minutes using an evaporator to remove ethanol, and then in a vacuum state for 15 hours. Freeze-drying was carried out to obtain 1.4 g of a solid powder. Next, the extract (powder solid) obtained as described above was dissolved in DMSO to 10, 100, 200 μg / μL to obtain a Clara extract-containing composition.

Regarding the coltsfoot extract, 100 g of a commercially available coltsfoot extract (trade name: coltsfoot extract, manufactured by Maruzen Pharmaceuticals Co., Ltd.) was concentrated under reduced pressure for 30 minutes using an evaporator to remove ethanol, and then freeze-dried in a vacuum state for 15 hours. This was carried out to obtain 2 g of a solid powder. Next, the extract (powder solid) obtained as described above was dissolved in DMSO to 10, 100, 200 μg / μL to obtain a coltsfoot extract-containing composition.

Regarding the extract of Tilia cordata, 100 g of a commercially available Tilia cordata extract (trade name: linden extract, manufactured by Maruzen Pharmaceuticals Co., Ltd.) was concentrated under reduced pressure for 30 minutes using an evaporator to remove ethanol, and then frozen in a vacuum for 15 hours. Drying was carried out to obtain 1.4 g of a powder solid. Next, the extract (powder solid) obtained as described above was dissolved in DMSO to 10, 100, 200 μg / μL to obtain a Tilia cordata extract-containing composition.

Regarding the Bukuryo extract, 100 g of a commercially available Bukuryo extract (trade name: Bukuryo extract, manufactured by Maruzen Pharmaceuticals Co., Ltd.) was concentrated under reduced pressure for 30 minutes using an evaporator to remove ethanol, and then freeze-dried in a vacuum state for 15 hours. This was carried out to obtain 0.4 g of a solid powder. Next, the extract (powder solid) obtained as described above was dissolved in DMSO to 10, 100, 200 μg / μL to obtain a Bukuryo extract-containing composition.

Regarding the lavender extract, 100 g of a commercially available lavender extract (trade name: lavender extract, lavender extract LA-J, manufactured by Maruzen Pharmaceuticals Co., Ltd.) was concentrated under reduced pressure for 30 minutes using an evaporator to remove ethanol, and then vacuumed. Freeze-drying was carried out in this state for 15 hours to obtain 4 g of a solid powder. Next, the extract (powder solid) obtained as described above was dissolved in DMSO to 10, 100, 200 μg / μL to obtain a lavender extract-containing composition.
2. Evaluation of sebum secretion promoting activity
-Culture of hamster sebaceous gland cells Normal hamster sebaceous gland cells (trade name: frozen Ha-SE (product number: KB-4009), purchased from Kurabo Industries Ltd.) are thawed and cultured so that the ^{number of cells is about 10,000 cells / cm 2.} The cells were seeded in a container and cultured in an incubator (37 ° C., 5% CO ₂ ) until they became almost confluent. For cell culture, sebaceous gland cell proliferation to which hEGF (human Epidermal Growth Factor) (10 ng / ml), fetal bovine serum (FBS) (8% V / V), and human serum (HS) (2% V / V) were added. The medium (product name: HuMedia-BG (product number: KB-2150S), purchased from Kurashiki Spinning Co., Ltd.) was used for culturing for 2 days.

Next, the proliferated hamster sebaceous filament cells were washed with HEPES (4- (2-hydroxyethyl) -1-piperazineethanesulfonic acid) buffer (purchased from Kurashiki Spinning Co., Ltd.) and then used with trypsin / EDTA solution (purchased from Kurashiki Spinning Co., Ltd.). After peeling from the culture medium and neutralizing with trypsin neutralizing solution (purchased from Kurashiki Spinning Co., Ltd.), seed the cells on a 24-well plate so as to have a cell number of ^{about 25,000 cells / cm 2 and proliferate sebaceous gland cells every other day.} The cells were cultured for 5 days while exchanging 500 μl of the medium (product name: HuMedia-BG (product number: KB-2150S)).
-Addition of extract Sebaceous gland cell differentiation in which 2 μL of each composition prepared as described above was added with fetal bovine serum (FBS) (8% V / V) and human serum (HS) (2% V / V). The medium for induction (product name: HuMedia-BD (product number: KB-2250S), purchased from Kurabo Industries Ltd.) was added to 1998 μL to make a total of 2000 μL. 500 μL of the mixture thus obtained was added to the wells of the above-mentioned plates and cultured at 37 ° C. for 17 days.

As a positive control, insulin (purchased from Kurabo Industries Ltd.) was dissolved in DMSO to 10 μg / μL to obtain a mixed solution, and then 2 μL of the obtained mixed solution was used as a medium for inducing sebaceous gland cell differentiation in the same manner as described above. The mixture obtained by adding to 1998 μL was added to the wells and cultured. As a negative control, a mixture obtained by adding 2 μL of DMSO to 1998 μL of a medium for inducing sebaceous gland cell differentiation in the same manner as described above was added to the wells and cultured.
-Measurement of cell number, measurement of lipid synthesis amount, and calculation of lipid synthesis amount After the above culture, according to the instruction manual, a cell number measurement solution (trade name: cell number measurement solution WST-8, Kurashiki Spinning Co., Ltd.) should be added to each well. (Purchased) was added and incubated at 37 ° C. for 30 minutes. Next, 0.2 ml / well of the supernatant was transferred to each 96-well plate, and the number of cells was measured by measuring the absorbance using an absorbance measuring device (model number GENios Spectra FLUOR plus, manufacturer name TEKAN, wavelength 450 nm). The number of cells can be measured by detecting the formazan product produced by the reduction of the tetrazolium salt.

Regarding the amount of lipid synthesis, Oil Red O staining was performed using a lipid synthesis measurement kit (trade name: lipid synthesis measurement kit SE-3001, purchased from Kurabo Industries Ltd.) according to the instruction manual. Specifically, the cells were washed twice with PBS (-) buffer, 10% formalin solution was added, and the cells were fixed by allowing them to stand at room temperature for 10 minutes, and the cells were treated with PBS (-) buffer. Washed twice. Next, 60% isopropanol, which is a solvent of the Oil Red O solution, was added in advance and allowed to stand at room temperature for 1 minute, then the Oil Red O solution was added and allowed to stand at room temperature for 30 minutes to stain the cells. Then, the cells were washed twice with 60% isopropanol, 100% isopropanol was added, and after permeating at room temperature for 5 minutes, 0.2 ml / well of the supernatant was transferred to a 96-well plate, and the absorbance was measured by an absorbance measuring device (wavelength 520 nm). ) Was used to measure the amount of lipid synthesis.

The amount of accumulated lipid synthesis per cell was calculated according to the following formula.
Lipid synthesis amount = absorbance 520 nm (measured value of lipid synthesis amount) / absorbance 450 nm (measured value of cell number)
-Results The results are shown in Fig. 1. As is clear from FIG. 1, in the above-mentioned extract, the amount of sebum produced increased in a concentration-dependent manner.

Oil Red O stain is a hydrophobic dye, has a high affinity for lipids, and stains triglycerides, cholesterol, etc., which are the main components of sebum. The sebaceous glands are holocrine. Furthermore, FIG. 1 shows the amount of lipid per cell because it shows the value obtained by dividing the amount of lipid by the number of cells. When the value of the negative control was 1, although not shown in FIG. 1, the amount of lipid per cell was significantly increased in the positive control.

From this, it was demonstrated that the extract caused the growth of lipid droplets in sebaceous gland cells and promoted the secretion of sebum.

From this, it was confirmed that the extract has a sebum secretion promoting action.
Formulation Example According to the following formulation example and description, an external composition for promoting sebum secretion containing at least one extract selected from the group consisting of Senkyu, Clara, Coltsfoot, Tilia cordata, Bukuryo and Lavender was produced. According to the external composition for promoting sebum secretion containing the extract, sebum secretion can be promoted.
-Toner Toner was obtained by mixing each component according to the composition shown in Table 1 below.

Emulsion By mixing and heating each component according to the composition shown in Table 2 below, components A and B heated to 80 ° C. or higher were obtained. Next, the A component and the B component were stirred and mixed, cooled to 50 ° C., the C component was added, and the mixture was further stirred and mixed to obtain a milky lotion.

-Cream By mixing and heating each component according to the composition shown in Table 3 below, components A and B heated to 80 ° C. or higher were obtained. Next, the A component and the B component were stirred and mixed, cooled to 50 ° C., the C component was added, and the mixture was further stirred and mixed to obtain a cream.

-Body shampoo Each component was mixed according to the composition shown in Table 4 below, and heated to 80 ° C. to obtain uniformly dissolved components A and B. Next, component B was added to component A, and the mixture was cooled to room temperature while stirring and mixing. A body shampoo was obtained by adding the C component to this.

-Soap Each component was mixed according to the composition shown in Table 5 below, and heated to 80 ° C. to obtain uniformly dissolved components A and B. Then, the B component was added to the A component to saponify it. This was cooled to 50 ° C. with stirring, and the C component was added thereto. This was poured into a mold and cooled, and then dried at room temperature for several days, and a sufficiently dried product was taken out from the mold to obtain soap.

-Anti-wrinkle cream Each component was mixed according to the composition shown in Table 6 below, and heated to 80 ° C. to obtain components A and B uniformly dissolved. Then, while stirring the component A with a homomixer, the component B was gradually added and emulsified. This was cooled with paddle stirring, and the C component was added and stirred at 50 to 35 ° C. to obtain an anti-wrinkle cream.

-Sunscreen cream Each component was mixed according to the composition shown in Table 7 below, and heated to 80 ° C. to obtain uniformly dissolved components A and B. Then, while stirring the B component with a homomixer, the A component was gradually added and emulsified. This was cooled with paddle stirring, the C component was added at around 50 ° C., and the stirring was stopped at 35 to 30 ° C. to obtain a sunscreen cream.

Essence: Mix each component according to the composition shown in Table 8 below, dissolve components A to D at room temperature, and gradually add component B while stirring component A to make a viscous liquid, and then C, The D component was added and homogenized to obtain a beauty essence.

-Foundation According to the composition shown in Table 9 below, the A component and the B component were mixed at 80 ° C., and the B component was gradually added while stirring the A component for emulsification. Then, the mixture was cooled with stirring, the C component was added at 50 ° C., and the stirring was stopped at 40 to 35 ° C. to obtain a foundation.

-Shampoo According to the composition shown in Table 10 below, the A component and the B component were heated and dissolved at 70 ° C., the B component was added to the A component, and the mixture was stirred and mixed. Then, the mixture was cooled with stirring, the C component was added at 50 ° C. or lower, and the stirring was stopped at 40 to 35 ° C. to obtain a shampoo.

-Rinse According to the composition shown in Table 11 below, the A component and the B component were heated and dissolved at 80 ° C., and the B component was gradually added and emulsified while stirring the A component. Then, the mixture was cooled with stirring, the C component was added at 50 ° C. or lower, and the stirring was stopped at 40 to 35 ° C. to obtain a rinse.

-Hair Treatment According to the composition shown in Table 12 below, the A component and the B component were heated and dissolved at 80 ° C., and the A component was gradually added and emulsified while stirring the B component. Then, the mixture was cooled with stirring, the C component was added at 50 ° C. or lower, and the stirring was stopped at 40 to 35 ° C. to obtain a hair treatment.

-Hair Liquid According to the composition shown in Table 13 below, component A was mixed at room temperature and dissolved uniformly. Then, the B component obtained by mixing was added to the A component with stirring to make it uniform, and a hair liquid was obtained.

-Body cream According to the composition shown in Table 14 below, components A and B were heated and dissolved at 70 ° C. Component A was added to component B, dispersed uniformly with a homomixer, and cooled with stirring. After the temperature reached 40 ° C., component C was added and cooled to room temperature with uniform stirring to obtain a body cream.

-Lip balm According to the composition shown in Table 15 below, component A was uniformly premixed, and component B was added and mixed uniformly. The C component was added thereto, and the mixture was heated to 70 to 80 ° C. with gentle stirring, and the D and E components were added little by little. Stirred evenly and poured into a mold to obtain lip balm.

-Cleansing cream According to the composition shown in Table 16 below, components A and B were each heated and dissolved at 80 ° C. and maintained at 65 ° C. While stirring the A component, the B component was gradually added and emulsified. These were cooled with stirring, the C component was added at 50 ° C. or lower, and the stirring was stopped at 40 to 30 ° C. to obtain a cleansing cream.

-Cleansing oil According to the composition shown in Table 17 below, each component was uniformly mixed to obtain a cleansing oil.

Facial cleansing foam According to the composition shown in Table 18 below, component A and component B are each heated and dissolved at 80 ° C. The C component dissolves at room temperature. While stirring the A component, gradually add the B component to dissolve it uniformly, and then add the C component to make it uniform. These were cooled with stirring, and the stirring was stopped at 35 to 30 ° C. to obtain a facial cleansing foam.

-Bath milk According to the composition shown in Table 19 below, the components A and B are each heated and dissolved at 70 ° C. While stirring component A with a homomixer, component B was added and emulsified. After that, it was cooled to 30 ° C. while stirring with a paddle to obtain bath milk.

-Toner According to the composition shown in Table 20 below, component B was mixed at room temperature, component A was added thereto, and the mixture was stirred and mixed to obtain a lotion.

-Beauty essence According to the composition shown in Table 21 below, the B component and the C component were stirred and mixed, and the D component was added to adjust the pH to 6. Next, component A was added and stirred with a homomixer, and a predetermined amount of component E was further added and then homogenized to obtain a beauty essence.

-Cream According to the composition shown in Table 22 below, an oil phase in which component A is heated to 80 ° C. and mixed, and an aqueous phase in which component B is heated to 80 ° C. and mixed are prepared, and then they are mixed and homomixed. Emulsified with. After stirring and cooling to 40 ° C., a predetermined amount of C component was added, and the mixture was further stirred and cooled to 30 ° C. to obtain a cream.

Claims (3)

A sebum secretagogue containing at least one alcohol extract selected from the group consisting of Senkyu, Clara, Coltsfoot, Tilia cordata, Bukuryo and lavender. An external composition for promoting sebum secretion, which contains the sebum secretion-promoting agent according to claim 1, for preventing or ameliorating skin symptoms associated with a decrease in sebum secretion. In the composition, at least one alcohol extract selected from the group consisting of Senkyu, Clara, Coltsfoot, Tilia cordata, Bukuryo and lavender is contained in an amount of 0.0001 to 20% by weight in terms of a dried product of the extract. , The external composition for promoting sebum secretion according to claim 2.

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