JP6925033B2 - Powder compression molding machine - Google Patents

Description

The present invention relates to a powder compression molding machine used for compressing powder to produce pharmaceutical tablets, foods, electronic parts, and the like.

A mortar hole is provided in the table of the turntable, and the upper and lower mortars are held slidably above and below each mortar, and both the mortar and the mortar are horizontally rotated to form a pair of the upper and lower mortars. A rotary powder compression molding machine is known that compresses the powder in the mortar when the mortar passes between the upper roll and the lower roll.

A nucleated tablet, that is, a layer composed of raw material powder, contains a nuclear tablet or other inner core or a semiconductor integrated circuit chip (sometimes referred to as an electronic device, IC tag or RFID tag) or the like. When molding a tablet, a core material is put into a powder-filled mortar, and then the mortar is filled with additional powder so as to cover the material, and then the upper and lower mortars are used. Perform compression tableting with. At this time, the core may move in the mortar due to the filling pressure of the additional powder, and the position of the core may deviate from the center of the completed molded product.

In order to properly place the nucleus in the center of the molded product, after inserting the nucleus into the mortar, insert the upper punch into the mortar from above and push the nucleus toward the powder in the mortar. It is possible to do it. However, in the process of such temporary compression, the upper punch must be raised and lowered significantly in a short period of time, and as a result, the rotation speed of the rotating disk cannot be increased, that is, a molded product that can be manufactured within a unit time. There is an inconvenience that the quantity of

In addition, as shown in FIG. 12, the tip surface 531 of the tip 53 of the upper punch 5 often has a cup shape recessed upward. When the core K is temporarily compressed with the upper punch 5 toward the powder M1, the air accumulated in the recess of the tip surface 531 of the tip 53 of the upper punch 5 is already filled in the mortar hole 4. It is possible that the powder M1 and the nucleus K are made to dance, and as a result, the nucleus K is displaced from an appropriate position.

Further, regardless of the shape of the tip surface of the tip 53 of the upper punch 5, the upper punch holding portion 32 for holding the upper punch 5 so as to be slidable up and down, and the upper punch 5 held by the upper punch holding portion 32. There is some clearance between the body and the body 52. Therefore, as shown in FIGS. 13 and 14, when the head 51 of the upper punch 5 rotating together with the upper punch holding portion 32 comes into contact with the roll 120 for temporary compression, or causes the upper punch 5 to move up and down. When sliding along the rail 190, the upper punch 5 slightly inclines with respect to the central axis of the mortar hole 4. This also causes a displacement of the core K when the core K is pushed by the upper punch 5.

On the other hand, as disclosed in the following patent documents, it has also been attempted to implement a mechanism for pushing the nucleus toward the powder in the mortar in the injection device itself for inserting the nucleus into the mortar. However, the mechanism that simultaneously supplies and pushes the nucleus into the acetabulum becomes complicated, the number of parts increases, and the cost rises.

JP-A-2002-065812 Japanese Unexamined Patent Publication No. 2015-229181

The present invention is a rotary powder compression molding machine that manufactures a molded product containing a nuclear lock or other inner core, a semiconductor integrated circuit chip, or the like, and is a core inside the molded product without adopting a complicated mechanism. The intended purpose is to be able to place the

In the present invention, a table having a mortar hole penetrating vertically, a turntable having a mortar holding portion for holding a mortar arranged above and below the mortar hole so as to be slidable up and down, and a mortar directly above the table and mortar. At a position directly above the table and downstream of the first filling device that overlaps the rotation trajectory of the mortar and the first filling device that is installed at a predetermined position that overlaps the rotation trajectory of the hole and fills the mortar with powder. It is installed at a position directly above the table and downstream of the charging device that overlaps with the rotation trajectory of the mortar, and the powder and nuclei are charged. The mortar is installed at a position directly above the table and downstream of the pressing member that overlaps with the rotation trajectory of the mortar, and the pressing member that contacts the nucleus and presses the nucleus before the upper punch is inserted into the mortar. A powder compression molding machine including a second filling device for filling the pores with powder was constructed.

In such a case, it is not necessary to incorporate a mechanism for pushing the nuclei toward the powder in the injecting device itself for injecting the nuclei into the mortar. In addition, since it is not necessary to insert the upper punch into the mortar and temporarily compress the core toward the powder, it is allowed to increase the rotation speed of the turntable, and molding that can be manufactured within a unit time. The quantity of goods increases.

Then, the pressing member comes into contact with the core that rises to a height equal to or higher than the upper surface of the table as the lower punch inserted into the mortar hole into which the powder and the core are inserted rises. It is preferable to hold down.

The powder is an aggregate of minute individuals, and is a concept including an aggregate of granules such as so-called granules and an aggregate of powder having a shape smaller than the granules. Examples of the powder include an excipient, a binder, a disintegrant, a stabilizer, a preservative, and the like, in addition to the powder containing the main agent. A powder obtained by mixing two or more kinds of powders is also a kind of powder referred to in the present invention, and a powder containing a main agent mixed with a lubricant such as magnesium stearate also corresponds to a powder.

According to the present invention, in a rotary powder compression molding machine that manufactures a molded product containing a nuclear lock or other inner core, a semiconductor integrated circuit chip, or the like, the core is formed inside the molded product without adopting a complicated mechanism. Can be placed in the proper position.

A side sectional view showing a rotary powder compression molding machine according to an embodiment of the present invention. The plan view of the powder compression molding machine of the same embodiment. The cylindrical view of the powder compression molding machine of the same embodiment. FIG. 3 is an enlarged cross-sectional view of a main part showing a pressing member in the powder compression molding machine of the same embodiment. FIG. 3 is an enlarged cross-sectional view of a main part showing a pressing member in the powder compression molding machine of the same embodiment. FIG. 3 is an enlarged cross-sectional view of a main part showing a molding process of a molded product by the powder compression molding machine of the same embodiment. FIG. 3 is an enlarged cross-sectional view of a main part showing a molding process of a molded product by the powder compression molding machine of the same embodiment. An enlarged cross-sectional view of a main part showing a holding member according to a modification of the present invention. An enlarged cross-sectional view of a main part showing a holding member according to the modified example. An enlarged cross-sectional view of a main part showing a holding member according to a modification of the present invention. An enlarged cross-sectional view of a main part showing a holding member according to the modified example. An enlarged cross-sectional view of a main part explaining a problem when performing temporary compression in which a nucleus is pushed toward a powder in a mortar with an upper punch. An enlarged cross-sectional view of a main part explaining a problem when performing temporary compression in which a nucleus is pushed toward a powder in a mortar with an upper punch. An enlarged cross-sectional view of a main part explaining a problem when performing temporary compression in which a nucleus is pushed toward a powder in a mortar with an upper punch.

An embodiment of the present invention will be described with reference to the drawings. The rotary powder compression molding machine of the present embodiment (hereinafter referred to as "molding machine") is for manufacturing a nucleated product in which a core K is embedded in a substrate formed by compressing powders M1 and M2. be. When the product is a pharmaceutical tablet, the powders M1 and M2 are powders containing an active ingredient or powders containing an active ingredient and an excipient. The core K may be a nuclear tablet (inner core) containing an active ingredient different from the raw material powders M1 and M2, or an integrated circuit chip.

First, the overall outline of this molding machine will be described. As shown in FIG. 1, a vertical shaft 2 serving as a rotating shaft is established in the frame 1 of the molding machine, and a rotating disk 3 is attached to an upper portion of the vertical shaft 2 via a connecting portion 21. The turntable 3 rotates horizontally, that is, rotates around the axis of the vertical shaft 2.

The turntable 3 includes a table (mortar disc) 31, an upper punch holding portion 32, and a lower punch holding portion 33. As shown in FIG. 2, the table 31 has a substantially disk shape, and a plurality of mortar holes 4 are provided at predetermined intervals along the rotation direction on the outer peripheral portion thereof. The mortar hole 4 penetrates the table 31 in the vertical direction. The table 31 may be divided into a plurality of plates. Further, instead of forming the mortar holes 4 directly in the table 31 itself, a plurality of mortars which are separate from the table 31 and which can be attached to and detached from the table 31 are attached to the table 31, and each of the mortars is equipped with a plurality of mortars. It is also possible to take a configuration in which a mortar hole penetrating in the vertical direction is formed.

Above and below each mortar hole 4, an upper mortar 5 and a lower mortar 6 are individually slidable with respect to the mortar 4 in the vertical direction, and the upper mortar holding portion 32 and the lower mortar holding portion 33 are formed. It is held by. The tip 53 of the upper punch 5 goes in and out of the mortar hole 4. The tip 63 of the lower punch 6 is always inserted into the mortar hole 4. The upper punch 5 and the lower punch 6 rotate horizontally, that is, revolve around the axis of the vertical shaft 2 together with the turntable 3.

A worm wheel 7 is attached to the lower end side of the vertical shaft 2. A worm gear 10 meshes with the worm wheel 7. The worm gear 10 is fixed to a gear shaft 9 driven by a motor 8. The driving force output by the motor 8 is transmitted to the gear shaft 9 by the belt 11 and rotationally drives the vertical shaft 2 and thus the turntable 3 and the punches 5 and 6 via the worm gear 10 and the worm wheel 7.

As shown in FIGS. 2 and 3, the upper and lower punches 6 are paired vertically on the orbit around the axis of the vertical shaft 2 of the upper and lower punches 6 so as to sandwich the upper and lower punches 6. There are a roll 12, a preload lower roll 13, a main pressure upper roll 14 and a main pressure lower roll 15. The preload upper roll 12 and the main pressure upper roll 14 press the head 51 of the upper punch 5, and the preload lower roll 13 and the main pressure lower roll 15 press the head 61 of the lower punch 6. Then, the preload upper roll 12 and the preload lower roll 13, and the main pressure upper roll 14 and the main reduction roll 15 compress the powders M1 and M2 filled in the mortar hole 4 from above and below on the tip surfaces of the punch tips 53 and 63. In order to do so, the upper punch 5 and the lower punch 6 are urged to approach each other.

The upper punch 5 and the lower punch 6 have heads 51 and 61 pressed by rolls 12, 13, 14 and 15, respectively, and body portions 52 and 62 having a diameter smaller than the heads 51 and 61, respectively. The upper punch holding portion 32 of the turntable 3 holds the body 52 of the upper punch 5 slidably up and down, and the lower punch holding portion 33 holds the body 62 of the lower punch 6 slidably up and down. do. The heads 51 and 61 of the upper punch 5 and the lower punch 6 engage with the guide rails 19 and 20 extending along the rotation direction of the turntable 3 (and the mortar hole 4, the upper punch 5 and the lower punch 6), respectively. do. The tips 53 and 63 connected to the tips of the torso 52 and 62, that is, the sides opposite to the heads 51 and 61, are thinner than the other parts so that they can be inserted into the mortar 4, and the mortar holes. The diameter is substantially equal to the inner diameter of 4.

The upper punch 5 and the lower punch 6 revolve together with the turntable 3, and in the process, rise and fall along the trajectories of the guide rails 19 and 20. Then, after the heads 51 and 61 of the punches 5 and 6 are separated from the guide rails 19 and 20, the rolls 12, 13, 14 and 15 approach the heads 51 and 61 of the punches 5 and 6 and the heads 51, Contact as if riding on 61. The rolls 12 and 14 push the upper punch 5 downward, and the rolls 13 and 15 push the lower punch 6 upward. While the rolls 12, 13, 14 and 15 are in contact with the flat surface on the heads 51 and 61 of the punches 5 and 6, the punches 5 and 6 are relative to the powders M1 and M2 filled in the mortar holes 4. Continue to apply the required pressure.

The molded product recovery unit 16 exists at a position downstream from the pressurizing position by the main compression upper roll 14 and the main compression lower roll 15 along the rotation direction of the turntable 3. A damper 17 for guiding the molded product extruded from the mortar hole 4 is installed in the molded product collecting unit 16. The damper 17 has a base end on the molded product collection position 18 side, and its tip extends so as to be closer to the center side of the table 31 than the rotation locus of the mortar hole 4. The molded product extruded from the mortar hole 4 by the lower punch 6 comes into contact with the damper 17 and moves toward the molded product collection position 18.

As shown in FIG. 2, in this molding machine, the first filling device X1 for filling the mortar hole 4 with the powder M1 and the mortar hole 4 filled with the powder M1 serve as a core K. The charging device Y for charging the input material, the pressing member Z for pushing the core K charged into the mortar hole 4 toward the powder M1 in the mortar hole 4, and the powder M1 were filled and the core K was charged. The second filling device X2 for further filling the mortar hole 4 with the additional powder M2, the above-mentioned preload rolls 12 and 13, the main pressure rolls 14 and 15, and the molded product recovery unit 16 are placed in the rotation direction of the turntable 3. They are arranged in this order along. In FIG. 2, the table 31 (and the turntable 3 including the punch holding portion 32 and the punches 5 and 6) rotate counterclockwise.

The first filling device X1 and the second filling device X2 are located on the outer peripheral portion of the rotating table 31 and directly above the rotation trajectory of the mortar hole 4, and the powders M1 and M2 are placed in the mortar hole 4 passing directly under the mortar hole 4. A known feed shoe to be filled. These filling devices X1 and X2 may be open feed shoes that simply drop the powders M1 and M2 into the mill hole 4, respectively, while rotating the built-in stirring blades to stir the powders M1 and M2. It may be a stirring feed shoe that is dropped into the mill hole 4, or it may be a combination of an open feed shoe and a stirring feed shoe. The powder M1 filled by the first filling device X1 and the powder M2 filled by the second filling device X2 may be of the same type or different types.

At the boundary between the first filling device X1 and the charging device Y, the powder M1 that was poured from the first filling device X1 but did not enter the mortar 4 and remained on the table 31 was charged in the charging device Y. A guide plate X11 is established to prevent the device from going to the side. The powder M1 remaining on the table 31 hits the guide plate X11 and is once guided in a direction approaching the rotation center of the table 31, that is, in a direction away from the mortar hole 4.

In addition, a guide plate X23 for recovering the powder M1 remaining on the table 31 to the second filling device X2 is established in the vicinity of the upstream end of the second filling device X2. The powder M1 that hits the guide plate X11 and is displaced toward the center of rotation of the table 31 moves with the rotation of the table 31 and then hits the guide plate X23. Is guided to and collected in the second filling device X2 through the collecting port R provided in the second filling device X2. Finally, the recovered powder M1 is filled in the mortar 4 together with the powder M2 in the second filling device X2.

The loading device Y located downstream of the first filling device X1 and upstream of the pressing member Z is located on the outer peripheral portion of the rotating table 31 and directly above the rotation trajectory of the mortar hole 4, and passes directly under the mortar hole 4. It is a known device that puts a product that becomes the core K of a molded product into the machine. Normally, the charging device Y loads one core K into one mortar hole 4 one by one, and incorporates one core K into one molded product. However, in the case of manufacturing a molded product containing a plurality of cores K, a plurality of cores K are charged into each mortar 4 from one charging device Y, or one core K is inserted into each mortar 4. A plurality of charging devices Y will be installed along the rotation direction of the turntable 3.

The pressing member Z located downstream of the charging device Y and upstream of the second filling device X2 is located on the outer peripheral portion of the rotating table 31 and directly above the rotation trajectory of the mortar hole 4. The pressing member Z is separate from the upper punch 5 and is independent of the loading device Y. At the position where the pressing member Z exists, the upper punch 5 is retracted to a position higher than the pressing member 5, and does not interfere with the pressing member 5. In this molding machine, the pressing member Z is immovably fixed, does not move up and down, and does not enter the mortar hole 4 (enter below the upper edge of the mortar hole 4). Further, as shown in FIGS. 4 and 5, in the region below the installation location of the pressing member Z, the guide rail 20 that engages with and guides the head 61 of the lower punch 6 rotates the turntable 3. The shape is such that the lower punch 6 is gradually raised as it progresses along the direction.

The lower surface of the pressing member Z is close to the upper surface of the table 31 and the upper edge of the mortar hole 4. The lower surface of the pressing member Z and the upper surface of the table 31 may be close to each other with substantially no gap, or the lower surface of the pressing member Z1 may be slightly lifted from the upper surface of the table 31. In the examples shown in FIGS. 4 and 5, a bulging portion Z0 that bulges downward is formed on (a part of) the lower surface of the pressing member Z, and the lowermost end of the bulging portion Z0 is on the upper surface of the table 31. Very close.

The process of manufacturing a molded product using this molding machine is as follows. First, as shown in FIG. 6 (I), the first filling device X1 fills the mortar hole 4 passing in the vicinity thereof with the powder M1. Prior to filling the powder M1, an injection device (not shown) for injecting a lubricant is provided on the inner peripheral surface of the mortar hole 4, the upper surface of the mortar tip 63 of the lower mortar 6 inserted into the mortar hole 4, and the upper surface of the mortar tip 63. A lubricant may be sprayed onto the lower surface of the tip 53 of the upper punch 5 which is held above the mortar hole 4.

Next, as shown in FIG. 6 (II), the throwing device Y throws the nucleus K into the mortar 4 passing in the vicinity thereof. Prior to the introduction of the core K, the lower punch 6 guided by the guide rail 20 is lowered by about several millimeters, so that the upper surface of the powder M1 filled in the mortar hole 4 is higher than the upper surface of the table 31. Immerse in a low position and create a space in the mortar 4 (above the powder M1 in) to receive the nucleus K.

Then, as shown in FIG. 6 (III), the lower punch 6 guided by the guide rail 20 when the mortar hole 4 filled with the powder M1 and into which the core K is inserted passes in the vicinity of the pressing member Z. Rises, and the tip 63 pushes up the powder M1 and the nucleus K in the mortar 4. As a result, at least the upper edge of the core K rises above the same height as the upper surface of the table 31 and comes into contact with the lower surface of the pressing member Z, and the core K pressed by the pressing member Z is the powder in the mortar hole 4. It is pushed downward toward the body M1. However, the pressing member Z may have an action of lightly pushing (or poking) the nucleus K. According to the examples shown in FIGS. 4 and 5, when the mortar hole 4 approaches directly below the pressing member Z, the lower punch 6 has already moved upward and the upper edge of the core K rises above the height of the upper surface of the table 31. With the subsequent rotation of the turntable 3, the core K comes into contact with the bulging portion Z0 of the pressing member Z and is pressed downward toward the powder M1 in the mortar hole 4.

Then, as shown in FIG. 7 (IV), the second filling device X2 fills the mortar 4 passing in the vicinity thereof with the additional powder M2. At this time, since the nucleus K is already buried in the powder M1 to some extent in the mortar 4, and the nucleus K is retained by the powder M1, the nucleus K is caused by the filling pressure of the additional powder M2. The position of is not unreasonably displaced in the mortar hole 4.

After that, as shown in FIG. 7 (V), the upper punch 5 and the lower punch 6 are pressed by the preload rolls 12 and 13 to precompress the powders M1 and M2 in the mortar hole 4, and further, the main pressure roll 14 , 15 presses to compress the powders M1 and M2 in the mortar hole 4. As a result, a molded product containing the core K, which is obtained by compressing the powders M1 and M2, is completed.

In the present embodiment, the rotation has a table 31 provided with a mortar hole 4 penetrating vertically and a mortar holding portion 32 for holding the mortars 5 and 6 arranged above and below the mortar hole 4 so as to be slidable up and down. The first filling device X1 which is installed at a predetermined position directly above the table 31 and overlapping the rotation trajectory of the mortar hole 4 and fills the powder M1 in the mortar hole 4, and the mortar hole 4 directly above the table 31 and the mortar hole 4. A charging device Y, which is installed at a position downstream of the first filling device X1 that overlaps with the rotation orbit, and a core K, which is an input different from the powders M1 and M2, is charged into the mortar hole 4, and a table 31. It is installed at a position directly above and downstream of the charging device Y that overlaps the rotation trajectory of the mortar 4, and the core K is before the upper punch 5 is inserted into the mortar 4 after the powder M1 and the core K have been charged. The pressing member Z that comes into contact with the core K and presses the core K is installed at a position directly above the table 31 and downstream of the pressing member Z that overlaps with the rotation trajectory of the mortar hole 4, and the mortar hole 4 is filled with powder M2. A powder compression molding machine equipped with a second filling device X2 was constructed.

According to the present embodiment, at least a part of the nucleus K is first filled after the injection device Y puts the core K into the mortar hole 4 and before the filling of the powder M2 by the second filling device X2. It can be pushed into the powder M1 to retain the position of the nucleus K in the mortar 4. Therefore, when the additional powder M2 is filled, the pressure of the powder M2 prevents the nucleus K from shifting from an appropriate position. Further, it is not necessary to incorporate a mechanism for pushing the core K toward the powder M1 in the charging device Y itself, which does not cause the charging device Y to become complicated and the cost to rise. In addition, since it is not necessary to perform temporary compression in which the upper punch 5 is inserted into the mortar hole 4 and the core K is pushed toward the powder M1, the rotation speed of the turntable 3 is allowed to be increased within a unit time. This makes it possible to manufacture a larger quantity of molded products.

Moreover, the pressing member Z is a core K that rises to a height equal to or higher than the upper surface of the table 31 as the lower punch 6 inserted in the mortar 4 into which the powder M1 and the core K are inserted rises. Since the core K is pressed in contact with the core K, the structure of the entire molding machine is not complicated, and the structure of the pressing member Z is also simple.

The present invention is not limited to the embodiments described in detail above. For example, as shown in FIGS. 8 and 9, the lower surface of the pressing member Z may be flat and horizontal. In this case, when the mortar hole 4 filled with the powder M1 and into which the core K is inserted passes in the vicinity of the pressing member Z, the lower punch 6 guided by the guide rail 20 rises, and the mortar tip 63 raises the mortar. Push up the powder M1 and the nucleus K in the hole 4. As a result, at least the upper edge of the core K rises to a height equal to or higher than the upper surface of the table 31, and comes into contact with the lower surface of the pressing member Z. After that, when the lower punch 6 is further raised, the nucleus K pressed by the pressing member Z is pushed downward toward the powder M1 in the mortar hole 4.

In the above embodiment, the pressing member Z is an immovable member close to the upper surface of the table 31, but as illustrated in FIGS. 10 and 11, the roller Z1 can be rotated to the support Z2 as the pressing member Z. It is also possible to adopt the one that has been supported. The roller Z1 (or the support Z2 supporting the roller Z1 together with the roller Z1) can move up and down within a certain range. The roller Z1 (or support Z2) may be elastically urged downward by a spring or other elastic member (not shown).

As shown in FIG. 10, when the mortar hole 4 does not exist directly under the roller Z1, the roller Z1 rides on the upper surface of the table 31. Then, as shown in FIG. 11, when the mortar hole 4 passes directly under the roller Z1 with the rotation of the turntable 3, the lower portion of the roller Z1 falls into the mortar hole 4, that is, the lower edge of the roller Z1 is moved. It enters below the upper edge of the mortar 4 and comes into contact with the core K, which is pushed downward toward the powder M1 filled in the mortar 4. At this time, it is not always necessary to raise the core K (upper edge) to a height equal to or higher than the upper surface of the table 31, and therefore it is not necessary to raise the lower punch 6 inserted into the mortar 4 (lower the guide rail 20). It is not necessary to set the shape to raise the mortar 6), but the lower mortar 6 may be intentionally raised to push up the core K and the powder M1 toward the roller Z1.

In addition, the specific configuration of each part can be variously modified without departing from the spirit of the present invention.

The present invention can be applied to a compression molding machine for compressing powder to produce pharmaceutical tablets and the like.

3 ... Rotating disk 31 ... Table 32 ... Crush holding part 4 ... Mill hole 5 ... Upper punch 6 ... Lower punch K ... Nuclear M1, M2 ... Powder X1 ... First filling device X2 ... Second filling device Y ... Input Device Z ... Holding member

Claims (1)

A table provided with mortar holes penetrating vertically, a rotating disk having a mortar holding portion for holding mortars arranged above and below the mortar holes so as to be slidable up and down, and a rotating disk.
A first filling device that is installed directly above the table and at a predetermined position that overlaps the rotation trajectory of the mortar and fills the mortar with powder.
A loading device that is installed directly above the table and downstream of the first filling device that overlaps the rotation trajectory of the mortar, and a loading device that throws a nucleus other than powder into the mortar.
It is installed directly above the table and on the downstream side of the loading device that overlaps the rotation trajectory of the mortar, and comes into contact with the core before the upper punch is inserted into the mortar after the powder and the core have been charged. A holding member that holds the nucleus and
It is provided with a second filling device that is installed directly above the table and on the downstream side of the pressing member that overlaps the rotation trajectory of the mortar, and fills the mortar with powder. A powder compression molding machine that presses the core in contact with the core that rises above the same height as the upper surface of the table as the lower punch inserted into the mortar is inserted.

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