JP6955974B2 - Liquid oral composition in a foam discharge container - Google Patents

Description

The present invention relates to a liquid oral composition containing a foam discharge container.

It is known that an oral composition containing an alkyl galactoside is excellent in a coagulation inhibitory effect on caries-causing bacteria such as Fusobacterium and periodontal disease-related bacteria present in dental plaque.
For example, Patent Document 1 describes that an oral composition containing an alkyl galactoside has an excellent effect of suppressing coagulation against caries-causing bacteria and periodontal disease-related bacteria in dental plaque, and can prevent dental caries and the like. There is. Further, Patent Document 2 describes an oral composition containing an alkyl galactoside that suppresses the precipitation of crystals such as menthol and ensures the stability of the composition.

Japanese Unexamined Patent Publication No. 2006-124384 Japanese Unexamined Patent Publication No. 2007-291806

However, when such an oral composition is applied in the form of a liquid or toothpaste, although it exerts an effect of suppressing coagulation on teeth, it is effective in suppressing the growth of bacteria on the tongue. The effect was not fully exhibited.

By applying a liquid composition containing a specific alkyl galactoside and an anionic surfactant to the oral cavity by foaming it with a foam discharge container, the present inventors have an excellent effect of suppressing bacterial growth on the tongue. I found that I could get it.

In the present invention, the following components (A), (B) and (C):
(A) General formula (1)

(In the formula, R represents a linear or branched alkyl group having 6 to 18 carbon atoms which may be substituted, G represents a galactose residue, E represents a hydrogen atom or a methyl group, and m is 0. Indicates an integer of ~ 200, n indicates an integer of 1 to 30)
Compound represented by 0.01 to 1.0% by mass,
(B) Anionic surfactant 0.01-2.0% by mass,
(C) The present invention relates to a liquid oral composition containing water and having a pH of 8.0 to 11.0 in a foam discharge container.

The liquid oral composition in a foam discharge container of the present invention contains an alkyl galactose (A) in which an alkyl group is ether-bonded to galactose and an anionic surfactant (B), and has a pH of 8 to 11. When applied into the oral cavity after being foamed in a foam discharge container or the like, the component (A) acts at a high concentration at the time of use, and is excellent in the effect of suppressing the growth of Fusobacterium spp. On the tongue.

The compound of the component (A) used in the present invention is represented by the general formula (1), and is directly connected to an alkyl group having 6 to 18 carbon atoms or via one or more oxyethylene groups or oxypropylene groups. A compound in which one or more galactose residues are ether-bonded in an α- or β-configuration.
The alkyl group represented by R may be either a straight chain or a branched chain, and specifically, an n-hexyl group, an n-heptyl group, an n-octyl group, an n-decyl group, an n-dodecyl group, n. -Tetradecyl group, n-hexadecyl group, n-octadecyl group, isodecyl group, isostearyl group (isooctadecyl group), 2-ethylhexyl group and the like can be mentioned. From the viewpoint of flavor, retention in the oral cavity, and foaming property, an alkyl group having 8 to 16 carbon atoms is preferable, an isodecyl group and a lauryl group are more preferable, and an isodecyl group is further preferable.

Further, one or more hydrogen atoms of the alkyl group may be substituted with a substituent, and the substituents include an alkoxy group having 1 to 6 carbon atoms and a halogen atom (eg, fluorine, chlorine, bromine, iodine, etc.). , A nitro group, a haloalkyl group having 1 to 6 carbon atoms, a haloalkoxy group having 1 to 6 carbon atoms, and the like.
In addition, galactose includes any of the pyranose-type, furanose-type or mixtures thereof. Although m represents an integer of 0 to 200, 0 to 12 is preferable, and 0 to 3 is more preferable from the viewpoint of the growth inhibitory effect of suppository bacteria. N, which indicates the degree of condensation of galactose, is an integer of 1 to 30, but is preferably 1 to 6 and more preferably 1 to 6 from the viewpoint of foaming property.

As the compound of the component (A), in the general formula (1), E is a hydrogen atom, the general formula (2).

(In the formula, R, G, m and n have the same meanings as described above)
The compound represented by is preferable.

Further, the compound of the component (A) may be a mixture containing two or more kinds of compounds represented by the general formula (3).

(In the formula, R'indicates a linear or branched alkyl group having an average carbon number of 6 to 18 which may be substituted, G indicates a galactose residue, E indicates a hydrogen atom or a methyl group, and x. Indicates an integer from 0 to 200, and y indicates an integer from 1 to 30)
In the general formula (3), the alkyl group which may be substituted with R'is an alkyl group having an average carbon number of 6 to 18, but has an average carbon number of 8 in terms of flavor, retention in the oral cavity, and foaming property. ~ 16 is preferable, and the average carbon number is 10 to 14. The average degree of polymerization x is a number of 0 to 200, preferably a number of 0 to 12, and more preferably a number of 0 to 3. The y indicating the average degree of condensation of galactose is a number of 1 to 30, but the number of 1 to 6 is preferable, and the number of 1 to 3 is more preferable from the viewpoint of the growth inhibitory effect of supraging bacteria.

The average degree of condensation y of galactose can be calculated based on the composition of the components of each degree of condensation obtained by an analytical method such as gel permeation chromatography. For example, in the case of an alkyl galactoside mixture having a degree of condensation of 1 to z of galactose, if the molar ratio of the galactoside having a degree of condensation z is a _z (a ₁ + a ₂ + a ₃ + ... + a _z = 1), the galactose The average degree of condensation is represented by y = a ₁ x 1 + a ₂ x 2 + ... + a _z x z = Σ (a _z x z).
Further, the average degree of polymerization x of the oxyethylene group or the oxypropylene group and the average number of carbon atoms of the alkyl group represented by R'can also be calculated in the same manner.

The compounds represented by the general formulas (1) to (3) can be produced by the method of Hori et al. (Pharmaceutical Journal, Vol. 79, No. 1, p80-83) or the like.
As the component (A), an alkyl galactoside having 8 to 12 carbon atoms is preferable from the viewpoint of an excellent effect of suppressing the growth of suppository bacteria, and isodecil is used from the viewpoint of alleviating the sensation of squeaking during use and having a good taste of the composition. Galactoside is more preferred.

As the component (A), one kind or two or more kinds can be used. The content of the component (A) is 0.01% by mass or more in the liquid oral composition containing a foam discharge container of the present invention from the viewpoint of sufficiently exerting the effect of suppressing the growth of oral bacteria, and is 0.03. It is preferably mass% or more, and more preferably 0.05 mass% or more. The content of the component (A) is 1.0% by mass or less in the liquid oral composition containing a foam discharge container from the viewpoint of good solubility in water and a preferable flavor of the component (C) described later. , 0.5% by mass or less, more preferably 0.1% by mass or less. The content of the component (A) is 0.01 to 1.0% by mass, preferably 0.03 to 0.5% by mass, and 0.05 to 0.05% by mass in the liquid oral composition in a foam discharge container. 0.1% by mass is more preferable.

The liquid oral composition in a foam discharge container of the present invention contains an anionic surfactant as the component (B). Examples of the anionic surfactant of the component (B) include alkyl sulfates such as lauryl sulfate and myristyl sulfate; alkyl phosphates such as lauryl phosphate; and α-olefins having 14 to 16 carbon atoms (olefins). C14-16) Sulfate; N-methylacyl taurine salt such as N-lauroyl sarcosin salt, N-myristoyl sarcosin salt; N-methylacyl taurine salt such as N-lauroyl methyl taurine salt, N-myristoyl methyl taurine salt; N-lauroyl N-acyl taurine salts such as taurine salt and N-myristoyl taurine salt; N-acyl glutamates such as N-lauroyl glutamate, N-myristoyl glutamate, N-palmitoyl glutamate, N-cocoyl glutamate and the like can be mentioned. ..
Among them, it is selected from N-acylamino acid salt, alkyl sulfate, alkyl phosphate, and α-olefin sulfonate from the viewpoint of good foaming property and sufficient effect of suppressing the growth of oral bacteria. It is preferable to use one or more anionic surfactants, and more preferably one or two or more anionic surfactants selected from N-acylamino acid salts and alkylsulfate salts, and N- It is more preferable to use an acyl amino acid salt and an alkyl sulfate ester salt in combination. Moreover, as these salts, sodium and potassium are preferable.

The content of the component (B) is 0.01% by mass in the liquid oral composition containing a foam discharge container from the viewpoint of exhibiting good foaming property and sufficiently exerting an effect of suppressing the growth of oral bacteria. As described above, 0.04% by mass or more is preferable, and 0.2% by mass or more is more preferable. The content of the component (B) is 2.0% by mass or less in the liquid oral composition containing a foam discharge container from the viewpoint of suppressing the effect of suppressing the growth of oral bacteria from diminishing or inactivating. , 1.4% by mass or less, more preferably 0.8% by mass or less. The content of the component (B) is 0.01 to 2.0% by mass, preferably 0.04 to 1.4% by mass, and 0.2 to 0.2 to 2.0% by mass in the liquid oral composition in a foam discharge container. 0.8% by mass is more preferable.

In the present invention, the mass ratio ((A) / (B)) of the content of the component (A) to the content of the component (B) is from the viewpoint of sufficiently exerting the effect of suppressing the growth of bacteria on the tongue. , It is preferably 0.05 or more, more preferably 0.1 or more, and further preferably 0.12 or more. In addition, the mass ratio ((A) / (B)) of the content of the component (A) to the content of the component (B) exerts good foaming property and suppresses the growth of bacteria on the tongue. From the viewpoint of sufficiently exerting the effect, it is preferably 6 or less, more preferably 2 or less, and further preferably 0.5 or less. The mass ratio ((A) / (B)) of the content of the component (A) to the content of the component (B) is preferably 0.05 or more and 6 or less, more preferably 0.1. It is ~ 2, and more preferably 0.12 to 0.5.

The liquid oral composition containing a foam discharge container of the present invention preferably contains an amphoteric tenside as a surfactant other than the above component (B) from the viewpoint of exhibiting good foaming properties.
Examples of amphoteric surfactants include betaine acetate such as lauryldimethylaminoacetic acid betaine; imidazolinium betaine such as 2-alkyl-N-carboxymethyl-N-hydroxyethyl-N-imidazolium betaine; laurylsulfobetaine and laurylhydroxysulfone. Alkyl sulfobetaine such as betaine; coconut oil fatty acid amide propyl betaine and the like coconut oil fatty acid amide alkyl betaine; preferably containing a long chain alkyl imidazoline betaine salt such as N-alkyl-1-hydroxyethyl imidazoline betaine sodium.
Among them, it is more preferable to contain coconut oil fatty acid amide alkyl betaine such as coconut oil fatty acid amide propyl betaine from the viewpoint of good foaming property and sufficient effect of suppressing bacterial growth on the tongue.

In the present invention, the content of the amphoteric tenside is 0.1% by mass in the liquid oral composition containing a foam ejection container from the viewpoint of a good effect of suppressing bacterial growth on the tongue and a good foam ejection property. The above is preferable, 0.2% by mass or more is more preferable, and 0.3% by mass or more is further preferable. The content of the amphoteric tenside is 5.0% by mass or less in the liquid oral composition containing a foam ejection container from the viewpoint of a good effect of suppressing bacterial growth on the tongue and a good foam ejection property. Preferably, it is 2.0% by mass or less, more preferably 1.0% by mass or less. The content of the amphoteric tenside is preferably 0.1 to 5.0% by mass, more preferably 0.2 to 2.0% by mass, and 0.3 by mass in the liquid oral composition in a foam discharge container. ~ 1.0% by mass is more preferable.

In the present invention, the mass ratio of the content of the component (A) to the content of the amphoteric surfactant ((A) / amphoteric surfactant) is a viewpoint that sufficiently exerts the effect of suppressing the growth of bacteria on the tongue. Therefore, it is preferably 0.05 or more, more preferably 0.08 or more, and further preferably 0.12 or more. In addition, the mass ratio of the content of the component (A) to the content of the amphoteric surfactant ((A) / amphoteric surfactant) exerts good foaming property and the growth of bacteria on the tongue. From the viewpoint of sufficiently exerting the suppressing effect, it is preferably 2 or less, more preferably 1 or less, and further preferably 0.5 or less. The mass ratio ((A) / amphoteric surfactant) of the content of the component (A) to the content of the amphoteric surfactant is preferably 0.05 or more and 2 or less, and more preferably 0. It is 08 to 1, and more preferably 0.12 to 0.5.

In the present invention, the mass ratio of the content of the component (B) to the content of the amphoteric surfactant ((B) / amphoteric surfactant) exhibits good foaming property and bacteria on the tongue. From the viewpoint of sufficiently exerting the growth inhibitory effect of the above, it is preferably 0.1 or more, more preferably 0.3 or more, and further preferably 0.5 or more. In addition, the mass ratio of the content of the component (B) to the content of the amphoteric surfactant ((B) / amphoteric surfactant) exerts good foaming property and the growth of bacteria on the tongue. From the viewpoint of sufficiently exerting the suppressing effect, it is preferably 3 or less, more preferably 2 or less, and further preferably 1.5 or less. The mass ratio ((B) / amphoteric surfactant) of the content of the component (B) to the content of the amphoteric surfactant is preferably 0.1 or more and 3 or less, and more preferably 0. It is 3 to 2, more preferably 0.5 to 1.5.

The water of the component (C) in the present invention is contained in a foam discharge container containing not only purified water and ion-exchanged water blended in the liquid oral composition in a foam discharge container but also water contained in each blended component. It means the total water content in the liquid oral composition.
The water content of the component (C) is preferably 35% by mass or more in the liquid oral composition containing a foam discharge container from the viewpoint of a good effect of suppressing the growth of bacteria on the tongue and a good foam discharge property. , 50% by mass or more is more preferable, and 60% by mass or more is further preferable. The water content of the component (C) is preferably 99% by mass or less, more preferably 85% by mass or less, and 75% by mass in the liquid oral composition containing a foam discharge container from the viewpoint of good foam discharge property. % Or less is more preferable. The content of the component (C) is preferably 35 to 99% by mass, more preferably 50 to 85% by mass, and even more preferably 60 to 75% by mass in the liquid oral composition in a foam discharge container.

The liquid oral composition containing a foam discharge container of the present invention further contains a quaternary ammonium compound as the component (D) from the viewpoint of sufficiently exerting the effect of suppressing the growth of bacteria on the tongue of the component (A). It is preferable to do so. Specifically, one or two selected from cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, chlorhexidine gluconate, and chlorhexidine hydrochloride are preferable, and from the viewpoint of bactericidal performance, cetylpyridinium chloride and benzethonium chloride are selected. One or more are more preferred, and cetylpyridinium chloride is even more preferred.

The content of the component (D) is preferably 0 in the liquid oral composition containing the foam discharge container of the present invention from the viewpoint of sufficiently exerting the effect of suppressing the growth of bacteria on the tongue of the component (A). It is 001% by mass or more, more preferably 0.003% by mass or more, and further preferably 0.006% by mass or more. Further, the content of the component (D) is preferably 0.1% by mass or less in the liquid oral composition containing the foam discharge container of the present invention from the viewpoint of maintaining a good usability, which is more preferable. Is 0.05% by mass or less, more preferably 0.03% by mass or less. The content of the component (D) is preferably 0.001% by mass or more and 0.1% by mass or less, more preferably 0.003, in the liquid oral composition containing the foam discharge container of the present invention. It is ~ 0.05% by mass, more preferably 0.006 to 0.03% by mass.

The liquid oral composition containing a foam discharge container of the present invention preferably further contains a binder from the viewpoint of ensuring good discharge from the container and achieving good foam quality.
Binders include sodium alginate, sodium carboxymethyl cellulose, carrageenan, xanthan gum, sodium polyacrylate, hydroxyethyl cellulose, hydroxypropyl cellulose, pectin, tragant gum, arabic gum, guar gum, karaya gum, locust bean gum, gellan gum, tamarind gum, psyllium. Seed gum, polyvinyl alcohol, sodium chondroitin sulfate, methoxyethylene maleic anhydride copolymer and the like can be mentioned, and one or more selected from sodium carboxymethyl cellulose, carrageenan, xanthan gum and hydroxyethyl cellulose are preferable, and among them, sodium carboxymethyl cellulose is preferable. , It is more preferable to contain hydroxyethyl cellulose.

The content of such a binder is preferably 0 in the liquid oral composition containing a foam discharge container of the present invention from the viewpoint of ensuring good discharge from the container and achieving good foam quality. It is 0.05% by mass or more, more preferably 0.1% by mass or more. The content of the binder is preferably 0.5% by mass or less in the liquid oral composition containing the foam discharge container of the present invention from the viewpoint of suppressing an appropriate discharge pressure from the foam discharge container. , More preferably 0.3% by mass or less. The content of the binder is preferably 0.05% by mass or more and 0.5% by mass or less, more preferably 0.1 to 1%, in the liquid oral composition containing the foam discharge container of the present invention. It is 0.3% by mass.

The liquid oral composition containing a foam discharge container of the present invention has an ethanol content of 10% by mass or less in the liquid oral composition containing a foam discharge container of the present invention from the viewpoint of ensuring foam retention. Is more preferably 8% by mass or less, further preferably 5% by mass or less, still more preferably 3% by mass or less, and particularly still more preferably 2% by mass or less, preferably 0% by mass. It is more than%, preferably 1% by mass or more.

The liquid oral composition containing a foam discharge container of the present invention has a content of abrasive powder of 0 in the liquid oral composition containing a foam discharge container of the present invention from the viewpoint of ensuring good discharge from the container. It is preferably 5.5% by mass or less, more preferably 0.4% by mass or less, further preferably 0.3% by mass or less, still more preferably 0.2% by mass or less, and preferably. The liquid oral composition in excess of 0% by mass or in a foam discharge container of the present invention preferably does not contain an abrasive powder. The content of the abrasive powder is preferably 0.5% by mass or less, more preferably 0 to 0.4% by mass, and further, in the liquid oral composition containing a foam discharge container of the present invention. It is preferably 0 to 0.3% by mass, more preferably 0 to 0.2% by mass, or the liquid oral composition in a foam discharge container of the present invention preferably does not contain an abrasive powder. ..
Examples of such abrasive powder include light calcium carbonate, heavy calcium carbonate, zeolite, abrasive silica having an oil absorption of 50 to 150 mL / 100 g, calcium dibasic phosphate, calcium tricalcium phosphate, insoluble sodium metaphosphate, and aluminum hydroxide. One or more selected from magnesium phosphate, calcium pyrophosphate, magnesium carbonate and the like can be mentioned. The amount of oil absorbed indicates the amount of oil that silica can support, and the measuring method is specified by the amount of oil absorbed in the boiled sardine by a method based on JISK5101-13-2 (established in 2004). ..

The liquid oral composition containing a foam discharge container of the present invention preferably further contains a wetting agent from the viewpoint of ensuring good discharge from the container and achieving good foam quality.
Examples of the wetting agent include glycerin, sorbitol, polyethylene glycol, propylene glycol, ethylene glycol, 1,3-butylene glycol, polypropylene glycol and the like, and one or a combination of two or more thereof can be blended. Among these, it is more preferable to contain glycerin and propylene glycol.
The content of these wetting agents is the liquid oral composition in a foam discharge container of the present invention from the viewpoint of achieving good foam quality, sufficiently exerting the foam retention and the effect of suppressing the growth of bacteria on the tongue. It is preferably 10 to 60% by mass, more preferably 15 to 40% by mass.

The liquid oral composition in a foam discharge container of the present invention can further contain a fluorine ion supply compound. Examples of the fluorine ion supply compound include sodium fluoride, potassium fluoride, ammonium fluoride, lithium fluoride, monofluorophosphate (for example, sodium monofluorophosphate, potassium monofluorophosphate, ammonium monofluorophosphate, etc.) and the like. Examples thereof include inorganic fluoride, organic fluoride such as amine fluoride, and tin fluoride, and among them, sodium fluoride, sodium monofluorophosphate, and tin fluoride are preferable.
The content of these fluorine ion-supplied compounds is preferably 0.01 to 2% by mass in the liquid oral composition containing the foam discharge container of the present invention from the viewpoint of regulation of taste and blending amount.

In addition to the above, the liquid oral composition containing a foam discharge container of the present invention contains components used in a normal liquid oral composition, for example, a surfactant other than the component (B) and an amphoteric surfactant, and an oily component. Perfumes, preservatives, medicinal agents, pH adjusters, pigments, pigments and the like can be appropriately contained.

The liquid oral composition in a foam discharge container of the present invention is a liquid oral composition prepared by mixing the components (A), (B) and (C), and is foam-discharged having a discharge port. It is filled in a container.
The liquid oral composition to be filled has a pH of 8.0 to 11.0 and a pH of 8.5 to 11 from the viewpoint of suppressing the decomposition of the component (A) and alleviating the oral mucosal irritation of the composition. 0 is preferable, and pH 9.0 to 11.0 is more preferable. The pH of the composition of the present invention is a value measured using a pH electrode at 20 ° C., and means a value measured for a liquid oral composition before foam ejection.
When the liquid oral composition containing a foam discharge container of the present invention is used, the liquid oral composition containing the contents is directly discharged into the oral cavity from the discharge port provided in the foam discharge container, and the discharge port is opened. The liquid oral composition that has passed through is applied into the oral cavity in the form of foam. In this way, by providing good foam quality, the above liquid oral composition can be spread in the oral cavity while experiencing an excellent feeling of use, and in particular, bacterial growth on the tongue of alkyl galactoside. The inhibitory effect can be effectively exerted.

The foam discharge container filled with the liquid oral composition may be any one provided with a discharge port, and may be a non-aerosol type container or an aerosol type container.

The non-aerosol type container is a normal pressure container that does not require a propellant such as a compressed gas, and examples of such a container include a squeeze type container and a pump type container. These containers have a viewpoint of forming a foamy composition well when the contents pass through the discharge port, and the formed foam has good retention and homogeneity, and enhances usability and the like. From this point of view, it is preferable that the container is formed by interposing a mesh or a porous member having a plurality of small holes in the flow path of the contents from the container body to the discharge port.

A squeeze-type container is a container in which the body located in the deformable container body is squeeze-deformed to mix the air and contents pumped from within the headspace while passing through a porous member as necessary. The bubbles are formed and the bubbles are discharged from the discharge port. Specifically, for example, the containers described in JP-A-7-215352, Jinkaisho 58-174272, and Jinkaisho 62-42787 can be used.

A pump-type container is a foam dispenser that has a discharge port. By pushing in the pump head, the air and contents that flow in from the outside are mixed and foamed while passing through a porous member as necessary. Is formed, and such bubbles are discharged from the discharge port. Usually, an air cylinder for inflowing air from the outside and a liquid cylinder serving as a flow path for the contents are provided, and a mixing chamber for mixing the air and the contents pumped by pushing the pump head is provided. Specifically, for example, the containers described in JP-A-7-315463, JP-A-8-230961, and Jitsukaihei 3-7963 can be used.

The aerosol type container is a container filled with compressed gas as a propellant, and when the contents are discharged from the discharge port, bubbles are formed while taking in the gas through the valve mechanism. The compressed gas to be used is preferably a gas containing 90% by mass or more of carbon dioxide gas.

As the foam discharge container used in the present invention, a squeeze container is preferable from the viewpoint of usability, that is, from the viewpoint of easily discharging the contents directly into the oral cavity from the discharge port, and from the viewpoint of excellent convenience and portability, and the container main body. A container having a mesh of # 90 to # 305 in the flow path of the contents from the to the discharge port is more preferable.

The liquid oral composition containing the foam discharge container of the present invention is a liquid oral composition prepared by mixing the components (A), (B) and (C), and the foam discharge port is provided. It is filled in a container, and it is desirable to use it by discharging the foam onto the tongue, gargle the foam so that it spreads throughout the mouth, and then brushing the oral cavity.

The liquid oral composition containing a foam discharge container of the present invention is excellent in the effect of suppressing the growth of Fusobacterium spp. On the tongue when used by directly applying it in the oral cavity in the form of foam. It is suitable as a liquid oral composition containing a foam discharge container.

（式中、Ｒは置換されてもよい炭素数６〜１８の直鎖又は分岐鎖状のアルキル基を示し、Ｇはガラクトース残基を示し、Ｅは水素原子又はメチル基を示し、ｍは０〜２００の整数を示し、ｎは１〜３０の整数を示す）で表される化合物 ０．０５〜０．１質量％、
（Ｂ）Ｎ−アシルアミノ酸塩、アルキル硫酸エステル塩から選ばれる１種又は２種以上のアニオン界面活性剤 ０．２〜０．８質量％、
（Ｃ）水 ５０〜８５質量％、
（Ｄ）第四級アンモニウム化合物 ０．００３〜０．０５質量％、
（Ｅ）両性界面活性剤 ０．１〜５質量％、
（Ｆ）湿潤剤 １５〜４０質量％
を含有し、成分（Ａ）の含有量と成分（Ｂ）の含有量との質量比（（Ａ）／（Ｂ））が０．０５以上６以下であり、成分（Ｂ）の含有量と成分（Ｅ）の含有量との質量比（（Ｂ）／（Ｅ））が０．１以上３以下であり、研磨性粉体の含有量が０．５質量％以下であるである泡吐出容器入り液体口腔用組成物であることが最も好ましい。 The liquid oral composition containing a foam discharge container of the present invention is from the viewpoint of ensuring good discharge from the container, achieving good foam quality, and sufficiently exerting the effect of suppressing the growth of oral bacteria. , The following components (A) to (F):
(A) General formula (1)

(In the formula, R represents a linear or branched alkyl group having 6 to 18 carbon atoms which may be substituted, G represents a galactose residue, E represents a hydrogen atom or a methyl group, and m is 0. Compounds represented by (indicating an integer of ~ 200, n represents an integer of 1 to 30) 0.05 to 0.1% by mass,
(B) One or more anionic surfactants selected from N-acylamino acid salt and alkyl sulfate ester salt 0.2 to 0.8% by mass,
(C) Water 50-85% by mass,
(D) Quaternary ammonium compound 0.003 to 0.05% by mass,
(E) Amphoteric surfactant 0.1 to 5% by mass,
(F) Wetting agent 15-40% by mass
The mass ratio ((A) / (B)) of the content of the component (A) to the content of the component (B) is 0.05 or more and 6 or less, and the content of the component (B) Foam discharge in which the mass ratio ((B) / (E)) to the content of the component (E) is 0.1 or more and 3 or less, and the content of the abrasive powder is 0.5% by mass or less. Most preferably, it is a liquid oral composition in a container.

With respect to the embodiments described above, the present invention further discloses the following compositions.

<1> The following components (A), (B) and (C):
(A) General formula (1)

(In the formula, R represents a linear or branched alkyl group having 6 to 18 carbon atoms which may be substituted, G represents a galactose residue, E represents a hydrogen atom or a methyl group, and m is 0. Indicates an integer of ~ 200, n indicates an integer of 1 to 30)
Compound represented by 0.01 to 1.0% by mass,
(B) Anionic surfactant 0.01-2.0% by mass,
(C) A liquid oral composition containing water and having a pH of 8 to 11 in a foam discharge container.

<2> The component (A) is preferably the general formula (2).

(In the formula, R represents a linear or branched alkyl group having 6 to 18 carbon atoms which may be substituted, G represents a galactose residue, m represents an integer of 0 to 200, and n is 1. Indicates an integer from ~ 30)
The liquid oral composition in a foam discharge container according to <1>, which is a compound represented by.

<3> The component (A) is preferably the general formula (3).

(In the formula, R'indicates a linear or branched alkyl group having an average carbon number of 6 to 18 which may be substituted, G indicates a galactose residue, E indicates a hydrogen atom or a methyl group, and x. Indicates an integer from 0 to 200, and y indicates an integer from 1 to 30)
The liquid oral composition in a foam discharge container according to <1>, which is a mixture containing two or more kinds of compounds represented by.

<4> The liquid oral composition in a foam discharge container according to <1>, wherein the component (A) is preferably an alkyl galactoside having 8 to 12 carbon atoms, more preferably an isodecyl galactoside.
<5> The content of the component (A) is preferably 0.03% by mass or more, more preferably 0.05% by mass or more, and 0.5% by mass in the liquid oral composition containing a foam discharge container. % Or less is preferable, and 0.1% by mass or less is more preferable. The liquid oral composition in a foam discharge container according to any one of <1> to <4>.

<6> The anionic surfactant of the component (B) is preferably one or more selected from N-acylamino acid salt, alkyl sulfate ester salt, alkyl phosphate, and α-olefin sulfonate. Therefore, one or more selected from N-acylamino acid salt and alkyl sulfate ester salt is more preferable, and it is more preferable to use N-acyl amino acid salt and alkyl sulfate ester salt in combination. > The liquid oral composition containing a foam discharge container according to any one of.
<7> The content of the component (B) is preferably 0.04% by mass or more, more preferably 0.2% by mass or more, and 1.4% by mass in the liquid oral composition containing a foam discharge container. % Or less is preferable, and 0.8% by mass or less is more preferable. The liquid oral composition in a foam discharge container according to any one of <1> to <6>.

<8> The mass ratio ((A) / (B)) of the content of the component (A) to the content of the component (B) is preferably 0.05 or more, more preferably 0.1 or more. , 0.12 or more, more preferably 6 or less, more preferably 2 or less, still more preferably 0.5 or less. ..
<9> The liquid oral composition in a foam discharge container according to any one of <1> to <8>, which preferably contains an amphoteric surfactant.

<10> The liquid oral composition in a foam discharge container according to <9> above, wherein the amphoteric tenside is preferably coconut oil fatty acid amide alkyl betaine, and more preferably coconut oil fatty acid amide propyl betaine.
<11> The content of the amphoteric surfactant is preferably 0.1% by mass or more, more preferably 0.2% by mass or more, and 0.3% by mass in the liquid oral composition containing a foam discharge container. % Or more is more preferable, 5% by mass or less is more preferable, 2% by mass or less is more preferable, and 1% by mass or less is further preferable.

<12> The mass ratio of the content of the component (A) to the content of the amphoteric surfactant ((A) / amphoteric surfactant). Preferably, it is 0.05 or more, more preferably 0.08 or more, further preferably 0.12 or more, preferably 2 or less, more preferably 1 or less, still more preferably 0.5 or less. The liquid oral composition containing a foam discharge container according to any one of <11>.
<13> The mass ratio of the content of the component (B) to the content of the amphoteric surfactant ((B) / amphoteric surfactant) is preferably 0.1 or more, and 0.3 or more. More preferably, 0.5 or more is further preferable, 3 or less is preferable, 2 or less is more preferable, and 1.5 or less is further preferable. Composition.
<14> The water content of the component (C) is preferably 35% by mass or more, more preferably 50% by mass or more, and further 60% by mass or more in the liquid oral composition containing a foam discharge container. The liquid oral composition in a foam discharge container according to any one of <1> to <13>, preferably 99% by mass or less, more preferably 85% by mass or less, still more preferably 75% by mass or less.

<15> The liquid oral composition in a foam discharge container according to any one of <1> to <14>, which preferably contains (D) a quaternary ammonium compound.
<16> The liquid oral cavity containing a foam discharge container according to <15>, wherein the quaternary ammonium compound is preferably one or more selected from cetylpyridinium chloride and benzethonium chloride, and cetylpyridinium chloride is more preferable. Composition for.
<17> The content of the component (D) is preferably 0.001% by mass or more, more preferably 0.003% by mass or more, and 0.006% by mass in the liquid oral composition containing a foam discharge container. % Or more is more preferable, 0.1% by mass or less is preferable, 0.05% by mass or less is more preferable, and 0.03% by mass or less is further preferable. Composition for.

<18> The liquid oral composition containing a foam discharge container according to any one of <1> to <17>, which preferably contains a binder.
<19> The binder is preferably one or more selected from sodium carboxymethyl cellulose, carrageenan, xanthan gum, and hydroxyethyl cellulose, and more preferably contains sodium carboxymethyl cellulose and hydroxyethyl cellulose. > The described liquid oral composition in a foam discharge container.
<20> The content of the binder is preferably 0.05% by mass or more, more preferably 0.1% by mass or more, and 0.5% by mass in the liquid oral composition in a foam discharge container. % Or less, more preferably 0.3% by mass or less. The liquid oral composition in a foam discharge container according to <18> or <19>.

<21> The content of ethanol is preferably 10% by mass or less, more preferably 8% by mass or less, further preferably 5% by mass or less, still more preferably 3% by mass or less, and particularly preferably 2 The liquid oral composition in a foam discharge container according to any one of <1> to <20>, wherein the mass% or less is particularly more preferable, and the mass% is preferably more than 0% by mass, preferably 1% by mass or more.
<22> The content of the abrasive powder is preferably 0.5% by mass or less, more preferably 0.4% by mass or less, further preferably 0.3% by mass or less, and 0.2% by mass. The liquid oral composition in a foam discharge container according to any one of <1> to <21>, wherein the following is even more preferable, preferably more than 0% by mass, or preferably not containing a abrasive powder.

<23> The liquid oral composition in a foam discharge container according to any one of <1> to <22>, which preferably contains a wetting agent.
<24> The wetting agent is preferably glycerin, sorbitol, polyethylene glycol, propylene glycol, ethylene glycol, 1,3-butylene glycol, or polypropylene glycol, and more preferably contains glycerin or propylene glycol. > The described liquid oral composition in a foam discharge container.
<25> The content of the wetting agent is preferably 10 to 60% by mass, more preferably 15 to 40% by mass in the liquid oral composition in a foam discharge container, said <23> or <24>. The liquid oral composition in a foam discharge container according to the above.

<26> The liquid oral composition in a foam discharge container according to any one of <1> to <25>, which preferably contains a fluorine ion supply compound.
<27> The liquid oral composition in a foam discharge container according to <26> above, wherein the fluorine ion supply compound is preferably sodium fluoride, sodium monofluorophosphate, or tin fluoride.

<28> The liquid oral cavity containing a foam discharge container according to any one of <1> to <27>, wherein the composition for a liquid oral cavity is preferably pH 8.5 to 11, and more preferably pH 9.0 to 11. Composition for.
<29> The foam discharge container is preferably a non-aerotype container or an aerosol type container, and a squeeze type container or a pump type container is more preferable. Liquid oral composition in a foam discharge container.
<30> The liquid oral composition in a foam discharge container according to any one of <1> to <29>, which is used for suppressing the growth of suppository bacteria.

[Production example of component (A)] Production of isodecyl galactoside:
D-galactose and isodecanol (Kyowa Hakko Chemical Co., Ltd.) were reacted in the presence of a catalytic amount of paratoluenesulfonic acid monohydrate while dehydrating under heating and reduced pressure conditions. After the reaction, an aqueous sodium hydroxide solution was added to neutralize the catalyst, and unreacted D-galactose was removed from the obtained mixture by filtration. Isodecyl galactoside was obtained by distilling off unreacted alcohol from the filtrate under reduced pressure. The average degree of galactose condensation of the obtained isodecyl galactoside was 1.14. This was used as an isodecyl galactoside.

Regarding Example 1 and Comparative Examples 1 and 2:
A liquid oral composition was prepared according to the formulation shown in Table 1, and the growth inhibitory effect of Fusobacterium spp. On the tongue was evaluated. The results are shown in Table 1.

In Example 1, the obtained liquid oral composition was filled in a pump former container (Daiwa Seikan Co., Ltd., F5 pump former, mesh: 2 sheets, mesh size: # 255 / # 255) and measured. Used for. Comparative Example 1 was used for the measurement as it was.

Each preparation was soaked for 30 seconds before going to bed, allowed to go to bed as it was, and the bacteria on the tongue the next morning were collected with a non-woven fabric. The number of bacteria attached to the non-woven fabric was quantified and measured by PCR. This was performed for 7 panelists, and the suppression rate (%) of each preparation when the number of bacteria of the preparation containing no isodecylgalactoside (Comparative Example 2) was 100 was determined. The results are shown in Table 1 as the average value of 7 persons.

Regarding Example 2 and Comparative Examples 3 to 4:
A liquid oral composition in a foam discharge container was prepared according to the formulation shown in Table 2, and the effect of suppressing the growth of Fusobacterium spp. On the tongue was evaluated. The results are shown in Table 2.

Similar to Example 1, in Example 2, the liquid oral composition obtained by mixing the components shown in the table is placed in a pump former container (Daiwa Seikan Co., Ltd., F5 pump former, mesh: 2). Sheets, mesh size: # 255 / # 255) were filled and used for measurement.

After cleaning the tongue with a non-woven fabric, each preparation was allowed to act, and the number of bacteria on the tongue after 4 hours was quantified and measured by PCR. Here, in the case of the foam preparation (Example 2), it was rinsed for 20 seconds and then brushed for 2 minutes. In the case of toothpaste (Comparative Example 3), it was brushed for 2 minutes. In the case of washing mouth with water (Comparative Example 4), the mouth was rinsed for 20 seconds. These measurements were carried out on 7 panelists, and the suppression rate (%) of each pharmaceutical product when the number of bacteria in the case of washing the mouth with water was 100 was determined. The results are shown in Table 2 as the average value of 7 people.

As the liquid oral composition containing a foam discharge container of the present invention, the compositions of the formulations shown below can be prepared by a conventional method and filled in the foam discharge container.

[Prescription Example 1: Liquid Oral Composition in Foam Discharge Container]
Dipotassium glycyrrhizinate 0.03% by mass
Cetylpyridinium chloride 0.03% by mass
Glycerin 18% by mass
Propylene glycol 8% by mass
Sodium lauryl sulfate 0.4% by mass
Coconut oil fatty acid amide propyl betaine 0.5% by mass
N-Millistoyl-L-monosodium glutamate 0.1% by mass
Sodium hydrogen carbonate 0.2% by mass
Sodium carbonate (anhydrous) 0.2% by mass
Isodecyl galactoside 0.08% by mass
Hydroxyethyl cellulose 0.3% by mass
Anhydrous sodium pyrophosphate 0.02% by mass
Purified water 72.14% by mass
100% by mass in total
(PH: 9)

[Prescription Example 2: Liquid Oral Composition in Foam Discharge Container]
Dipotassium glycyrrhizinate 0.02% by mass
Cetylpyridinium chloride 0.05% by mass
Glycerin 22% by mass
Propylene glycol 8% by mass
Sodium lauryl sulfate 0.5% by mass
Coconut oil fatty acid amide propyl betaine 0.6% by mass
N-Millistoyl-L-monosodium glutamate 0.1% by mass
Sodium hydrogen carbonate 0.2% by mass
Sodium carbonate (anhydrous) 0.3% by mass
Isodecyl galactoside 0.15% by mass
Carrageenan 0.2% by mass
Anhydrous sodium pyrophosphate 0.01% by mass
Purified water 67.87% by mass
100% by mass in total
(PH: 10)

Claims (6)

The following components (A), (B) and (C):
(A) General formula (1)

(In the formula, R represents a linear or branched alkyl group having 6 to 18 carbon atoms which may be substituted, G represents a galactose residue, E represents a hydrogen atom or a methyl group, and m is 0. Indicates an integer of ~ 200, n indicates an integer of 1 to 30)
Compound represented by 0.01 to 1.0% by mass,
(B) Anionic surfactant 0.01-2.0% by mass,
(C) Contains water, the mass ratio of the content of the component (A) to the content of the component (B) ((A) / (B)) is 0.1 or more and 2 or less, and the pH is 9. A liquid oral composition containing a foam discharge container of 0 to 11.0. The liquid oral composition in a foam discharge container according to claim 1, wherein the component (A) is isodesyl galactoside. The liquid oral composition in a foam discharge container according to claim 1 or 2 , further comprising a binder. The liquid oral composition in a foam discharge container according to any one of claims 1 to 3 , further comprising a quaternary ammonium compound. The liquid oral composition in a foam discharge container according to any one of claims 1 to 4 , wherein the content of the abrasive powder is 0.5% by mass or less. The following components (A), (B) and (C):
(A) General formula (1)

(In the formula, R represents a linear or branched alkyl group having 6 to 18 carbon atoms which may be substituted, G represents a galactose residue, E represents a hydrogen atom or a methyl group, and m is 0. Indicates an integer of ~ 200, n indicates an integer of 1 to 30)
Compound represented by 0.01 to 1.0% by mass,
(B) Anionic surfactant 0.01-2.0% by mass,
(C) Contains water, the mass ratio of the content of the component (A) to the content of the component (B) ((A) / (B)) is 0.1 or more and 2 or less, and the pH is 9. A liquid oral composition containing a foam discharge container for suppressing the growth of supraging bacteria, which is 0 to 11.0.