JP6967447B2 - Tablet denture cleanser - Google Patents

Description

The present invention relates to a tablet-shaped denture cleanser having a wide range of tableting conditions that do not cause a tableting disorder.

Regardless of whether the denture is a complete denture or a removable partial denture, bacteria, biofilms, and other deposits are likely to adhere to the denture, and if left unwashed, it not only causes bad breath, but also periodontal disease. It may contribute to the induction of oral diseases such as. Therefore, it is essential to clean and keep the denture clean as part of oral care. Bacteria and dirt adhering to the denture cannot be sufficiently removed by cleaning with a brush, so cleaning with a denture cleaner is important.

Cleaning of a denture with a denture cleaning agent is generally performed by a method of immersing the denture in the denture cleaning water prepared by adding the denture cleaning agent to water. Conventionally, a surfactant and a foaming agent have been blended in the artificial tooth cleaning agent, and when they are put into water, they exert the chemical cleaning power by the surface activating action and the physical cleaning power by the foaming action, and the cleaning effect is enhanced. It is designed to be.

In addition, conventionally, denture cleansers are formulated and provided in various forms such as tablets, granules, and powders. Among these pharmaceutical forms, tablets are easy to handle and are suitable for consumers. Widely accepted. So far, various pharmaceutical formulations for improving the detergency and disintegration of tablet-shaped denture detergents have been reported (see, for example, Patent Documents 1 and 2).

Japanese Patent Publication No. 2001-505195 Japanese Unexamined Patent Publication No. 2005-12640

Since the tablet-shaped artificial tooth cleaning agent contains a foaming agent (carbonic acid compound and acid), it has the characteristic of being inferior in tableting moldability, and has capping (an event in which the top and bottom of the tablet are peeled off) and lamination (the middle part of the tablet). Tableting disorders such as sticking (an event in which a part of the raw material adheres to a mortar or a mortar and a part of the tablet is peeled off) tend to occur. Therefore, in the production of a tablet-shaped denture detergent, tableting conditions such as preload and main pressure that do not cause tableting failure are set according to the composition. However, if the range of locking conditions that does not cause a locking failure is narrow, strict control of the locking conditions is required during industrial manufacturing, and even if the locking conditions are controlled more strictly, the temperature fluctuates. Inevitably, a locking disorder may occur due to the influence of the condition of the raw material. Therefore, it is desired to develop a tablet-shaped denture cleanser having a wide range of tableting conditions that does not cause a tableting disorder.

Therefore, an object of the present invention is to provide a tablet-shaped denture cleanser having a wide range of tableting conditions that does not cause a tableting disorder.

As a result of diligent studies to solve the above-mentioned problems, the present inventor has found that a tablet-shaped denture detergent containing an alkyl glycoside together with a foaming agent (carbonic acid compound and acid) has a tableting condition that does not cause a tableting disorder. It was found that the range of pressure conditions) becomes wider. The present invention has been completed by further studies based on such findings.

That is, the present invention provides the inventions of the following aspects.
Item 1. Tablets containing (A) at least one carbonate compound selected from the group consisting of carbonates, bicarbonates, and compound salts of hydrogen carbonates and carbonates, (B) acids, and (C) alkyl glycosides. Shaped artificial tooth cleaning agent.
Item 2. Item 2. The tablet-shaped denture detergent according to Item 1, wherein the alkyl glucoside is an alkyl glucoside having a hydrocarbon moiety having 8 to 22 carbon atoms.
Item 3. Item 2. The tablet-shaped denture cleanser according to Item 1 or 2, wherein the alkyl glycoside is contained in an amount of 0.1 to 3% by weight.
Item 4. The tablet-shaped denture detergent according to any one of Items 1 to 3, further comprising (D) polyalkylene glycol.
Item 5. Item 2. The tablet-shaped denture cleanser according to Item 4, wherein the polyalkylene glycol is polyethylene glycol.
Item 6. Item 2. The tablet-shaped denture cleanser according to Item 4 or 5, wherein the polyalkylene glycol is contained in an amount of 0.1 to 3% by weight.
Item 7. The tablet-shaped denture detergent according to any one of Items 1 to 6, further comprising (E) a bleaching agent.
Item 8. The tablet-shaped denture detergent according to any one of Items 1 to 7, further comprising (F) sugar alcohol.
Item 9. Raw material mixture containing (A) at least one carbonate compound selected from the group consisting of carbonates, bicarbonates, and compound salts of hydrogen carbonates and carbonates, (B) acids, and (C) alkyl glycosides. A method for producing a tablet-shaped artificial tooth cleaning agent, which is subjected to a tableting step.

Since the tablet-shaped denture detergent of the present invention has a wide range of tableting conditions that do not cause tableting trouble, it is easy to control the tableting conditions, and further, tableting due to the influence of temperature fluctuations, raw material conditions, etc. Obstacles can be suppressed. Therefore, the tablet-shaped denture cleaning agent of the present invention can suppress manufacturing loss in the tableting process and can realize high manufacturing efficiency in industrial manufacturing.

1. 1. Artificial tooth cleaning agent The artificial tooth cleaning agent of the present invention is in the form of a tablet and is at least one carbonate compound selected from the group consisting of (A) carbonate, hydrogen carbonate, and a compound salt of hydrogen carbonate and carbonate. , (B) Acid, and (C) Alkyl Glycoside. Hereinafter, the denture detergent of the present invention will be described in detail.

(A) Carbonate Compound The artificial tooth cleaning agent of the present invention contains at least one carbonate compound selected from the group consisting of carbonate, hydrogen carbonate, and a compound salt of hydrogen carbonate and carbonate. The carbonic acid compound becomes a constituent component of the foaming agent and plays a role of reacting with an acid to generate carbon dioxide gas when cleaning the denture.

The carbonate is not particularly limited, and examples thereof include alkali metal salts of carbonic acid such as sodium carbonate and potassium carbonate. Among these, sodium carbonate is preferably mentioned.

The hydrogen carbonate is not particularly limited, and examples thereof include alkali metal salts of hydrogen carbonate such as sodium hydrogen carbonate (baking soda) and potassium hydrogen carbonate. Among these, sodium hydrogen carbonate is preferable.

The double salt of carbonate and hydrogen carbonate is not particularly limited, and examples thereof include sodium sesquicarbonate and the like.
These carbonic acid compounds may be used alone or in combination of two or more.

Among these carbonic acid compounds, sodium carbonate and sodium hydrogen carbonate are preferable.

The content of the carbonic acid compound in the denture cleaning agent of the present invention is not particularly limited as long as it can exert a foaming action when cleaning the denture, but for example, the total amount of the carbonic acid compound is 5 to 60% by weight, preferably 5 to 60% by weight. 10 to 50% by weight, more preferably 15 to 50% by weight.

(B) Acid The denture cleanser of the present invention contains an acid. The acid becomes a constituent component of the foaming agent and plays a role of reacting with a carbonic acid compound to generate carbon dioxide gas when cleaning a denture.

As the acid, a solid acid at room temperature is preferably used. Further, the acid may be either an organic acid or an inorganic acid.

The organic acid is not particularly limited, and examples thereof include citric acid, tartaric acid, fumaric acid, malic acid, maleic acid, gluconic acid, succinic acid, and salicylic acid.

The inorganic acid is not particularly limited, and examples thereof include phosphoric acid and sulfamic acid.

These acids may be used alone or in combination of two or more. Among these acids, organic acids are preferable, citric acid and malic acid are more preferable.

The content of the acid in the artificial tooth cleaning agent of the present invention is not particularly limited as long as it can react with the carbonic acid compound in water to generate carbon dioxide. 20 to 100 parts by weight, preferably 30 to 90 parts by weight, more preferably 40 to 85 parts by weight.

Further, in the denture cleaning agent of the present invention, the total amount of the carbonic acid compound and the acid (the sum of the content of the carbonic acid compound and the content of the acid) is, for example, 10 to 85% by weight, preferably 20 to 80% by weight. %, More preferably 30 to 75% by weight.

(C) Alkyl Glycoside The denture cleanser of the present invention contains an alkyl glycoside. The alkyl glycoside plays a role in improving the tableting formability and widening the range of tableting conditions (pressure conditions) that do not cause tableting disorders in the tablet-shaped denture detergent containing the carbonic acid compound and acid.

The alkyl glycoside is a compound in which an alcohol is bound to a sugar by a glycosidic bond and has a hydrocarbon moiety and a sugar moiety.

The hydrocarbon moiety constituting the alkyl glycoside may be linear or branched, and may be saturated or unsaturated, but a linear or branched saturated hydrocarbon is preferable. Can be mentioned. The number of carbon atoms in the hydrocarbon moiety is not particularly limited, and examples thereof include 8 to 22, preferably 10 to 16, and more preferably 10 to 14.

The sugar moiety constituting the alkyl glycoside may be a monosaccharide, an oligosaccharide, or a polysaccharide. The degree of condensation of the sugar moiety (that is, the number of monosaccharides constituting the sugar moiety) is, for example, 1 to 10, preferably 1 to 5, more preferably 1 to 3, still more preferably 1 or 2, particularly preferably. Is 1 (that is, the sugar portion is a monosaccharide). Specific examples of the sugar moiety include monosaccharides such as glucose, galactose, xylose, fructose, mannose, lyxose, and apibinose; oligosaccharides such as maltose, xylobiose, isomannose, lactose, sucrose, raffinose, and maltotriose. Can be mentioned. Among these, monosaccharides or disaccharides are preferable, monosaccharides are preferable, and glucose is more preferable.

Specific examples of the alkyl glucoside include octyl glucoside, decyl glucoside, lauryl glucoside, mysticyl glucoside, palmytyl glucoside, stearyl glucoside, and oleyl glucoside; Alkyl glucosides such as palmityryl glucoside, stearyl glucoside, and oleyl glucoside; octylfurctoside, decylfluctside, laurylfurctoside, mystililfructoside, palmyrylfurctoside, stearylfluctside, oleylflu Alkyl glucosides such as coutoside; alkyl multosides such as octyl multoside, decyl multoside, lauryl multoside, mysticyl multoside, palmytyl multoside, stearyl multoside, oleyl multoside; octyl glucoside, decyl glucoside. , Alkyl glucoside such as lauryl glucoside, mysticyl scroside, palmityryl scroside, stearyl scroside, oleyl scroside and the like.

These acids may be used alone or in combination of two or more. Among these alkyl glycosides, from the viewpoint of further widening the range of tableting conditions that do not cause tableting disorders, a hydrocarbon moiety having 10 to 16 carbon atoms and a sugar composed of monosaccharides or disaccharides are preferable. Alkyl glucoside having a moiety; more preferably an alkyl glucoside having a hydrocarbon moiety having 10 to 16 carbon atoms; still more preferably an alkyl glucoside having a hydrocarbon moiety having 10 to 14 carbon atoms; particularly preferably lauryl glucoside. Can be mentioned.

Examples of the content of the alkyl glycoside in the denture detergent of the present invention include 0.1 to 3% by weight. From the viewpoint of further widening the range of tableting conditions that do not cause tableting disorder, the content of the alkyl glycoside is preferably 0.5 to 2% by weight, more preferably 1 to 2% by weight.

(D) Polyalkylene Glycol The denture detergent of the present invention may contain polyalkylene glycol in addition to the above-mentioned components. The polyalkylene glycol serves as a binder and can further widen the range of tableting conditions that do not cause a tableting disorder.

The number of carbon atoms of the alkylene group constituting the polyalkylene glycol is not particularly limited, and examples thereof include 2 to 4, preferably 2 or 3, and more preferably 2. The average number of moles of alkylenoxide added to the polyalkylene glycol is not particularly limited, and examples thereof include 100 to 250, preferably 130 to 230, and more preferably 160 to 210.

Specific examples of the polyalkylene glycol include polyethylene glycol, polypropylene glycol, polybutylene glycol and the like.

These polyalkylene glycols may be used alone or in combination of two or more. Among these polyalkylene glycols, polyethylene glycol is preferable from the viewpoint of further widening the range of tableting conditions that do not cause a tableting disorder.

When polyalkylene glycol is blended in the denture detergent of the present invention, the content thereof may be, for example, 0.1 to 2% by weight. The content of the polyalkylene glycol is preferably 0.5 to 2% by weight, more preferably 0.5 to 1, from the viewpoint of further effectively widening the range of tableting conditions that do not cause tableting trouble. 5% by weight is mentioned.

(E) Bleach The cleaning agent of the present invention may contain a bleach, if necessary. When the denture cleaning agent of the present invention contains a bleaching agent, it is possible to impart a bleaching action and improve the cleaning power.

The type of bleaching agent used in the present invention is not particularly limited as long as it is non-toxic and physiologically acceptable, and those usually used for denture cleansing agents can be widely used.

Examples of the bleaching agent include percarbonate, perborate, persulfate, monosulfuric acid salt and the like.

Specific examples of the percarbonate include alkali metal salts of percarbonate such as sodium percarbonate and potassium percarbonate, ammonium percarbonate, and hydrates thereof. Specific examples of the perborate include alkali metal salts of perboric acid such as sodium perborate and potassium perborate, ammonium perborate, and hydrates thereof. Specific examples of the persulfate include alkali metal salts of persulfate such as sodium persulfate and potassium persulfate, ammonium persulfate, and hydrates thereof. Specific examples of the monopersulfate hydrogen salt include alkali metal salts of monopersulfate such as sodium monosulfate and potassium monosulfate, ammonium monosulfate, and hydrates thereof. ..

These bleaching agents may be used alone or in combination of two or more. Among these bleaches, preferably an alkali metal salt of monohydrosulfate and an alkali metal salt of perborate, more preferably potassium hydrogen monopersulfate, and sodium perborate.

When a bleaching agent is added to the denture detergent of the present invention, the content thereof may be appropriately set within a range capable of exerting a desired bleaching action. For example, the total amount of the bleaching agent is 10 to 40% by weight. It is preferably 10 to 35% by weight, more preferably 13 to 30% by weight.

(F) Sugar alcohol The denture cleanser of the present invention may contain sugar alcohol in addition to the above-mentioned components. The sugar alcohol serves as a binder, and in particular, when used in combination with polyalkylene glycol, the range of tableting conditions that do not cause tableting disorder can be further widened.

The type of sugar alcohol is not particularly limited, and examples thereof include sorbitol, mannitol, xylitol, and erythritol.

These sugar alcohols may be used alone or in combination of two or more. Among these sugar alcohols, sorbitol is preferable.

When sugar alcohol is blended in the denture detergent of the present invention, the content thereof is, for example, 1 to 30% by weight, preferably 3 to 20% by weight, more preferably 4 to 15% by weight, based on the total amount of sugar alcohol. Can be mentioned.

(G) Lubricants The denture cleanser of the present invention preferably contains a lubricant in order to facilitate the molding process into tablets.

The type of lubricant is not particularly limited, and examples thereof include magnesium stearate, calcium stearate, sodium stearyl fumarate, sodium sucrose fatty acid ester, sodium lauryl sulfate, talc, light anhydrous silicic acid, and hydrous silicon dioxide. ..

These lubricants may be used alone or in combination of two or more. Among these lubricants, magnesium stearate, calcium stearate, and more preferably magnesium stearate can be mentioned.

When the lubricant is added to the denture cleanser of the present invention, the content thereof is, for example, 0.01 to 1% by weight, preferably 0.015 to 0.5% by weight, and more preferably 0.02 to 0% by weight. 0.3% by weight is mentioned.

(H) Surfactants other than alkyl glycosides Alkyl glycosides have a surface-active effect in addition to the role of expanding the range of tableting conditions that do not cause tableting disorders, and also exert a cleaning effect on artificial teeth. The artificial tooth cleaning agent of the present invention may not contain a surfactant other than the alkyl glycoside, but preferably contains a surfactant other than the alkyl glycoside in order to enhance the detergency.

The type of surfactant (other than alkyl glycoside) blended in the artificial tooth cleaning agent of the present invention is not particularly limited as long as it can be used as a component of the cleaning agent, and is cationic, anionic, or non-cationic. Either an ionic or amphoteric surfactant may be used.

Specific examples of the cationic surfactant include quaternary ammonium salts such as alkyl (C6 to C20) trimethylammonium salt, dialkyl (C6 to C20) dimethylammonium salt, and alkyl (C6 to C20) dimethylbenzylammonium salt. Examples thereof include salts, alkyl (C6 to C20) amine salts, alkyl (C6 to C20) amine ethylene oxide adducts, and alkylpyridinium salts. These cationic surfactants may be used alone or in combination of two or more.

Specific examples of the anionic surfactant include a linear alkylbenzene sulfonate having an alkyl group having an average carbon number of 10 to 16, an alkenyl sulfonate having an average of 10 to 20 carbon atoms in one molecule, and an average. A linear alkyl sulfoacetate having an alkyl group having 10 to 20 carbon atoms, an alkyl sulfate having an alkyl group having an average carbon number of 10 to 20, an alkane sulfonate having an average carbon atom of 10 to 20 in one molecule, etc. Can be mentioned. These anionic surfactants may be used alone or in combination of two or more.

Specific examples of the nonionic surfactant include higher alcohol ethylene oxide adduct, alkylphenol ethylene oxide adduct, fatty acid ethylene oxide adduct, polyhydric alcohol fatty acid ester ethylene oxide adduct, and higher alkylamine ethylene oxide adduct. , Fatty acid amide ethylene oxide adducts, polyethylene glycol-type surfactants such as fats and oils ethylene oxide adducts and polypropylene glycol ethylene oxide adducts, as well as glycerol fatty acid esters, pentaerythritol fatty acid esters, sorbitol and sorbitan fatty acid esters, and sho. Examples thereof include polyhydric alcohol-type surfactants such as fatty acid esters of sugars, alkyl ethers of polyhydric alcohols, and fatty acid amides of alkanolamines. These nonionic surfactants may be used alone or in combination of two or more.

Specific examples of the amphoteric surfactant include an amino acid-type surfactant such as an alkylaminopropionate having an alkyl group having an average carbon number of 10 to 16 (for example, sodium laurylaminopropionate), and an average carbon number of 10 to 16. Examples thereof include alkyldimethylbetaine having an alkyl group (lauryldimethylbetaine, stearyldimethylbetaine, etc.), betaine-type surfactant such as laurylhydroxyethylbetaine, and the like. These amphoteric surfactants may be used alone or in combination of two or more.

In the various surfactants, the salt forms include alkali metal salts such as sodium and potassium, alkaline earth metal salts such as magnesium and calcium, ammonium salts, amine salts, and acid addition salts such as hydrochlorides. Can be mentioned.

Among these surfactants, anionic surfactants are preferable. These surfactants may be used alone or in combination of two or more.

When a surfactant (other than an alkyl glycoside) is contained in the artificial tooth cleaning agent of the present invention, the content thereof may be appropriately set according to the type of the surfactant to be used, the detergency to be provided, and the like. For example, the total amount of the alkyl glycoside and the surfactant other than the alkyl glycoside is 0.1 to 10% by weight, preferably 0.5 to 5% by weight, and more preferably 1 to 4% by weight.

Other Ingredients In addition to the above-mentioned ingredients, the denture cleansing agent of the present invention contains other additives as necessary for the purpose of enhancing detergency, imparting disintegration property, imparting moldability, and the like. May be.

Other additives that can be added to the artificial tooth cleaning agent of the present invention include rust preventives, chelating agents, pH adjusters, enzymes, colorants, sweeteners, foam stabilizers, preservatives, antibacterial / bactericidal agents, and preservatives. Examples include agents, binders (other than alkylene glycols and sugar alcohols), bulking agents, excipients, disintegrants and the like.

Pharmaceutical form The denture cleanser of the present invention is in the form of tablets. The formulation into a tablet form can be carried out by a generally adopted tableting molding method. For example, a raw material mixture of a carbonic acid compound, an acid, an alkyl glycoside and, if necessary, other additives may be subjected to the tableting step. Further, prior to the tableting step, the mixture may be granulated into granules, if necessary. In the present invention, since the range of the locking conditions (pressing conditions) at which the tableting failure does not occur is widened, the locking conditions can be easily controlled, and the tableting is further affected by the influence of the temperature fluctuation, the state of the raw material, and the like. Locking disorders can be suppressed.

Further, in the denture cleaning agent of the present invention, the weight per tablet is not particularly limited and may be appropriately set in consideration of ease of use, but the weight per tablet is necessary for one denture cleaning. It is desirable to set it to a reasonable amount. Specifically, the weight per tablet of the denture detergent of the present invention is 1 to 4 g, preferably 2 to 3 g.

Method of Use The denture cleaning agent of the present invention can clean a denture by coexisting the denture to be cleaned in a state of being added to water. When the denture detergent of the present invention contains a foaming agent (carbonic acid compound and acid), foaming occurs due to the foaming agent in water, which causes physical irritation to the denture, alkyl glucoside and, if necessary. The denture can be effectively cleaned by the surface-active action of other added surfactants.

The water used for cleaning the denture using the denture cleaning agent of the present invention is not particularly limited, and examples thereof include tap water, purified water, and physiological saline.

When cleaning a denture using the denture cleaning agent of the present invention, the denture cleaning agent of the present invention may be added after immersing the denture in water, or the denture cleaning agent of the present invention may be added to water and then the denture. May be immersed.

Further, in denture cleaning, the ratio of the denture cleaning agent of the present invention to water is appropriately set according to the composition of the denture cleaning agent of the present invention, the degree of stain on the denture to be cleaned, and the like. The amount of the denture cleaning agent may be usually about 1 to 10 parts by weight, preferably about 1 to 5 parts by weight with respect to 100 parts by weight of water. More specifically, in one denture cleaning, 100 to 200 ml of water may be prepared, and 1 to 20 g, preferably 1 to 10 g of the denture cleaning agent of the present invention may be added thereto.

The water temperature at the time of cleaning the denture may be about 5 to 40 ° C. The time for immersing the denture in the water containing the denture cleaning agent of the present invention is usually about 5 minutes to 12 hours, preferably about 30 minutes to 8 hours.

2. 2. Denture Cleaning Method The denture cleaning method of the present invention is a method of cleaning a denture using the denture cleaning agent. That is, the denture cleaning method of the present invention is a method of immersing a denture in water containing the denture cleaning agent to clean the denture. Specific embodiments of the denture cleaning method of the present invention are as described in the column of "1. Denture cleaning agent" above.

Hereinafter, the present invention will be specifically described with reference to Examples, but the present invention is not limited to these Examples.

The trade names, compositions, sources, etc. of the main ingredients used in the following test examples and prescription examples are as follows.
Lauryl glucoside: Product name "Glucopon 50G" (manufactured by BASF Japan Ltd.)
Potassium Sulfate, Potassium Hydrogen Sulfate, and Potassium Monopersulfate Mixture (Contains Approximately 43% by Weight of Potassium Monopersulfate): Trade Name "OXONE" (manufactured by LANXESS Co., Ltd.)
Sodium perborate : Product name "SODIUM PERBORATE MONOHYDRAT" (made by BELINKA)
Polyethylene glycol : Product name "PEG6000P" (manufactured by Daiichi Kogyo Co., Ltd.)
Sodium α-olefin sulfonate : Product name "ASCO-90" (manufactured by Aekyung Specialty Chemicals Co. Ltd.)
Sodium lauryl sulfate : Product name "Emar 10PHD" (manufactured by Kao Corporation)

Test Example Using a tableting device (CLEANPRESS Model No. 1518SS7JY, manufactured by Kikusui Seisakusho Co., Ltd.), the raw material mixture having the composition shown in Table 1 is tableted by changing the pressure conditions at the time of preload and main pressure (per tablet). 2.65 g). For each obtained tablet, the hardness (measured with a schroingel hardness tester (tablet hardness tester 6D: manufactured by DR.SCHLEUNIGER PHARMATRON)) and thickness were measured, and the presence or absence of tableting failure (capping, lamination, sticking) occurred. Was observed. The range of tableting conditions for obtaining tablets (passing tablets) having a hardness of 8 sc or more and a thickness of less than 3.90 mm and in which neither capping nor lamination was observed was evaluated based on the following criteria. ..
<Criteria for determining the tableting conditions for obtaining acceptable tablets>
A: As the range of tableting conditions for obtaining acceptable tablets, the preload filling depth range was 1.5 mm or more, and the main pressure range was more than 1.5 tons.
B: As the range of tableting conditions for obtaining acceptable tablets, the preload filling depth range was 1 mm or more and less than 1.25 mm, and the main pressure range was more than 1.5 tons.
C: As the range of tableting conditions for obtaining acceptable tablets, the range of the preload filling depth was less than 1 mm, and the range of the main pressure was 1.5 tons or less.

The results are shown in Table 1. The tablet containing a foaming agent (carbonic acid compound and acid) and not containing lauryl glycoside (Comparative Example 1) had a determination result of C, and the tableting conditions for obtaining a passing tablet were narrow. Further, even with tablets containing only one of a carbonic acid compound or an acid and lauryl glycoside (Comparative Examples 2 and 3), the tableting conditions for obtaining acceptable tablets were narrowed. On the other hand, in the tablets (Examples 1 to 6) containing a lauryl glycoside together with a foaming agent (carbonic acid compound and acid), the determination result was A or B, and the tableting conditions for obtaining a passing tablet were widened. In particular, for tablets containing 1% by weight or more of lauryl glycoside and 1% by weight or more of polyethylene glycol together with a foaming agent (carbonic acid compound and acid) (Examples 1 to 3 and 6), the tableting conditions for obtaining acceptable tablets are particularly wide. It was.

The raw material mixture having the composition shown in Prescription Example Table 2 was tablet-molded to obtain a tablet-shaped denture detergent (2.65 g per tablet). All of these denture cleansers had a wide range of tableting conditions that did not cause tableting disorders and were good.

Claims (9)

Tablets containing (A) at least one carbonate compound selected from the group consisting of carbonates, bicarbonates, and compound salts of hydrogen carbonates and carbonates, (B) acids, and (C) alkyl glycosides. Shaped artificial tooth cleaning agent. The tablet-shaped denture detergent according to claim 1, wherein the alkyl glucoside is an alkyl glucoside having a hydrocarbon moiety having 8 to 22 carbon atoms. The tablet-shaped denture cleanser according to claim 1 or 2, wherein the alkyl glycoside is contained in an amount of 0.1 to 3% by weight. The tablet-shaped denture cleanser according to any one of claims 1 to 3, further comprising (D) polyalkylene glycol. The tablet-shaped denture cleanser according to claim 4, wherein the polyalkylene glycol is polyethylene glycol. The tablet-shaped denture cleanser according to claim 4 or 5, wherein the polyalkylene glycol is contained in an amount of 0.1 to 3% by weight. The tablet-shaped denture cleanser according to any one of claims 1 to 6, further comprising (E) a bleaching agent. The tablet-shaped denture cleanser according to any one of claims 1 to 7, further comprising (F) sugar alcohol. Raw material mixture containing (A) at least one carbonate compound selected from the group consisting of carbonates, bicarbonates, and compound salts of hydrogen carbonates and carbonates, (B) acids, and (C) alkyl glycosides. A method for producing a tablet-shaped artificial tooth cleaning agent, which is subjected to a tableting step.