JP6986985B2 - Pharmaceuticals, dehumidifiers, fungicides and acaricides using the pharmaceuticals - Google Patents

Description

The present invention relates to a pharmaceutical product, a dehumidifying agent using the pharmaceutical product, an antifungal agent and an anti-tick agent.

Conventionally, various component substances having excellent actions such as sterilization, antibacterial, antifungal, and antimite have been known. For example, allyl isothiocyanate (that is, allyl isothiocyanate; hereinafter may be abbreviated as AIT), which is a component of wasabi, has an antifungal effect and an antimite effect.

On the other hand, some component substances having antifungal and antimite effects have a pungent odor. For example, AIT has a peculiar strong pungent odor, and when used at a high concentration, there is a problem that the pungent odor adheres to the surroundings.
Therefore, it is necessary to effectively exert antifungal and anti-mite effects with as little amount as possible.

High antifungal and anti-tick effects are also recognized in the vapor of the component substance having anti-mold and anti-tick effects. Therefore, by utilizing the vapor of such a component substance, it is possible to exert the antifungal and antimite effects in a small amount in the storage space of clothes, foods and the like.

However, some of the component substances having antifungal and antimite effects are highly volatile. For example, since AIT is extremely volatile, if AIT is used as it is, the concentration of vapor of AIT in the surrounding environment increases in a short time, but the antifungal effect and the like are not sustained. In addition, since a pungent odor is generated in the target space, there is a concern that the pungent odor may adhere to clothes and foods stored in the target space, for example.

Therefore, there is a demand for the development of a pharmaceutical product capable of controlling the vapor release rate of such a component substance and maintaining the AIT concentration in the target space at a predetermined concentration for a long period of time.

Japanese Patent No. 3140824 proposes a food having a long-lasting antifungal effect by adding an inclusion material in which AIT is encapsulated with cyclodextrin (hereinafter, may be abbreviated as CD). There is. Encapsulation with cyclodextrin can chemically stabilize AIT and suppress the volatility of AIT vapor.

Japanese Patent No. 3140824

However, the component substance enclosed in a CD, for example, the AIT enclosed in a CD (hereinafter referred to as CD-AIT), does not release the vapor of the component substance unless the humidity is above a certain level, and has an effect of preventing mold and the like. Not demonstrated. On the contrary, if the humidity is too high, the inclusion force of the cyclodextrin inclusions weakens and the constituent substances are rapidly released, which not only gives the user discomfort due to the pungent odor peculiar to the constituent substances, but also causes the target space. There is a problem that the antifungal and anti-tick effects cannot be continuously given.

Therefore, the present invention adjusts the inflow of water vapor to a predetermined amount in both a low humidity environment and a high humidity environment, and releases the vapor of a component substance having an effect such as antifungal activity at a predetermined release rate. To provide a formulation, a dehumidifying agent, an antifungal agent and an antifungal agent that continuously imparts antifungal and antifungal effects to the target space and does not give the user discomfort due to the pungent odor peculiar to the component substance. The purpose.

According to one aspect of the present invention, the container having at least a part of the moisture-permeable film having a breathability in the range of 1500 to 8000 sec / 100 cc, the deliquescent substance hermetically stored in the container, and the above-mentioned It is possible to provide a preparation having a cyclodextrin inclusion substance, which is a component substance having an antifungal or anti-mite effect, which is hermetically encapsulated in a containment body.

According to one aspect of the present invention, it is possible to provide a dehumidifying agent having the formulation of the present invention.

According to one aspect of the present invention, it is possible to provide an antifungal agent having the formulation of the present invention.

According to one aspect of the present invention, it is possible to provide an acaricide having the preparation of the present invention.

According to the present invention, the inflow amount of water vapor is adjusted to a predetermined amount in both a low humidity environment and a high humidity environment, and the vapor of a component substance having an effect such as antifungal discharge is released at a predetermined release rate. Therefore, it is possible to provide a formulation, a dehumidifying agent, an antifungal agent and an antifungal agent that continuously provide antifungal and antifungal effects to the target space and does not give the user discomfort due to the pungent odor peculiar to the component substance. can.

It is a schematic block diagram which shows the structure of the dehumidifying agent which concerns on embodiment of this invention. It is a schematic diagram for demonstrating the situation that AIT is not released enough when the amount of calcium chloride is too small with respect to CD-AIT. It is a schematic diagram for demonstrating the situation which the release rate of AIT becomes high when the moisture permeability is high, that is, the air permeability is small in a high humidity environment. It is a schematic diagram for demonstrating the situation which the release rate of AIT is adjusted appropriately when the film of appropriate air permeability is used in a high humidity environment. It is a figure which shows the test result of a plurality of moisture-permeable films with different air permeability and an odor used in the Example of this invention. It is a graph which shows the time change of the sensory evaluation result of 5 Examples and 4 comparative examples of FIG. It is a figure which shows the test result of the volatilization state of AIT when the ratio of the amount of CD-AIT and the amount of calcium chloride was changed, which was used in the Example of this invention. It is a graph which shows the time change of the sensory evaluation result of FIG. It is a block diagram of the dehumidifying agent using the molding member of the non-moisture permeable resin.

Hereinafter, embodiments of the present invention will be described with reference to the drawings.
FIG. 1 is a schematic configuration diagram showing the configuration of the dehumidifying agent according to the present embodiment. In the present embodiment, the component substance having antifungal and antimite effects is AIT. AIT encapsulated with CD is used as a cyclodextrin inclusion substance having an antifungal or anti-mite effect.

The dehumidifying agent 1 is composed of a bag body 2, CD-AIT3 as a cyclodextrin inclusion, and calcium chloride (CaCl ₂ ) 4 as a deliquescent substance.
The bag body 2 is formed by adhering the outer peripheral portions of the non-moisture permeable film 2a and the moisture permeable film 2b with an adhesive or the like so as to form the internal space IS. That is, the bag body 2 as an accommodating body for containing the cyclodextrin inclusions and the deliquescent substance in a sealed manner is formed by laminating the non-moisture permeable film 2a and the moisture permeable film 2b.

The non-breathable film 2a shown by the solid line does not have breathability. The air permeability (sec / 100cc) of the non-moisture permeable film 2a is extremely large, and the non-moisture permeable film 2a hardly allows moisture to pass through.

The moisture-permeable film 2b shown by the alternate long and short dash line has breathability and allows moisture WV such as humidity and water vapor to pass therethrough. The air permeability of the moisture permeable film 2b is 30 to 8000 sec / 100 cc.

The component substance having an antifungal or anti-mite effect is allyl isothiocyanate (AIT). CD-AIT3 is a cyclodextrin inclusions of allyl isothiocyanate (AIT).

Calcium chloride (CaCl ₂ ) 4 is a deliquescent substance. Although calcium chloride (CaCl ₂ ) 4 is used here as the deliquescent substance, other deliquescent substances such as magnesium chloride (MgCl ₂ ) may be used.

CD-AIT3 and calcium chloride 4 are enclosed in the internal space IS of the bag body 2. Therefore, the bag body 2 is a container that houses the CD-AIT 3 and the calcium chloride 4 inside.
As described above, the dehumidifying agent 1 of the present embodiment is housed in a container having at least a part of a breathable film having a breathability in the range of 30 to 8000 sec / 100 cc and hermetically sealed in the container. It contains a preparation having a deliquescent substance and a cyclodextrin inclusions of a component substance having an antifungal or anti-mite effect, which is hermetically stored in a containment body.

The air permeability of the moisture permeable film is preferably in the range of 400 to 8000 sec / 100 cc.
The dehumidifying agent 1 of the present embodiment exhibits a dehumidifying effect and also exhibits an antifungal and anti-mite effect by AIT.

In particular, since the moisture-permeable film 2b having a predetermined air permeability is used for a part of the bag body 2, water vapor permeates the air-permeable surface of the moisture-permeable film 2b having a predetermined air permeability. Therefore, a dehumidifying agent that continuously exerts an effect such as antifungal effect by adjusting the amount of water that comes into contact with the CD-AIT to an appropriate amount is provided.

Even in a low humidity environment, the dehumidifying agent 1 produces an aqueous calcium chloride solution in the bag due to the deliquescent action of calcium chloride 4. FIG. 2 is a schematic diagram for explaining a situation in which AIT is not sufficiently released when the amount of calcium chloride is too small with respect to CD-AIT.
The moisture-permeable film 2b1 of FIG. 2 has high moisture permeability, and as shown in FIG. 2, if the amount of calcium chloride is too small with respect to CD-AIT, the amount of aqueous solution 5 produced is small and AIT is not sufficiently released.

FIG. 3 is a schematic diagram for explaining a situation in which the release rate of AIT is high when the moisture permeability is high, that is, the air permeability is low in a high humidity environment.
The moisture-permeable film 2b1 has high moisture permeability, and as shown in FIG. 3, the deliquescent rate of calcium chloride is high, and the release rate of AIT is also high.

FIG. 4 is a schematic diagram for explaining a situation in which the release rate of AIT is appropriately adjusted when a film having an appropriate air permeability is used in a high humidity environment. As shown in FIG. 4, even in a high humidity environment, the deliquescent rate of calcium chloride 4 is adjusted and the release rate of AIT is appropriately adjusted by using a film having an appropriate air permeability.

That is, by using a film having an appropriate air permeability for the bag body 2, the deliquescent rate of calcium chloride 4 is adjusted, and the release rate of AIT is appropriately adjusted. As a result, the dehumidifying agent 1 continuously exerts an effect such as antifungal effect.
(Example)
Next, examples of the dehumidifying agent of the present invention will be described.

FIG. 5 shows the test results of the plurality of moisture permeable films 2b having different air permeability and the odor used in this example. FIG. 5 shows five examples and four comparative examples. The table of FIG. 5 has items of moisture permeable films, contents and odors (effects) having different air permeability. The air permeability is shown in units of sec / 100cc. The content indicates a substance contained in the bag body 2. The odor (effect) indicates the odor of the test result.

FIG. 6 is a graph showing the time change of the sensory evaluation results of the five examples and the four comparative examples of FIG. FIG. 6 is a graph in which the evaluation results for each hour within 8 hours after the dehumidifying agent is placed in a predetermined environment are plotted.

The size of the ventilation surface of the moisture-permeable film 2b of the bag body 2 used in this test is 95 mm × 110 mm.
A plurality of moisture permeable films 2b having an air permeability in the range of 0 to 25000 sec / 100 cc are used.

The air permeability was measured in accordance with P8117 of the Japanese Industrial Standards (JIS). For the measurement, a Wangken type aeration meter was used.
In the bag body 2 used in this test, 20 g (gram) of calcium chloride 4 and 0.05 g (gram) of CD-AIT3 were sealed and contained as agents. These agents are housed and sealed in a bag body 2 having the size of the above-mentioned ventilation surface, and in a high humidity environment, where the room temperature is 25 ° C (that is, 25 degrees Celsius) and the relative humidity is 80%. Under the environment, the volatilization status of AIT was confirmed by sensory evaluation.

In the evaluation, the level of odor intensity was determined by 5 subjects, and the evaluation was performed on a 6-point scale, and the average value of the 5 subjects was used as the evaluation value. In FIG. 3, the odor intensity level 0 indicates the level of odorlessness, level 1 indicates the level of odor that can be finally perceived, level 2 indicates the level of weak odor that can be understood what the odor is, and level 3 indicates the level of weak odor. , Indicates a level of easily perceptible odor, level 4 indicates a level of strong odor, and level 5 indicates a level of intense odor.

In FIG. 6, the odor having an odor intensity in the range of 1 to 2 exerts an effect such as antifungal effect without giving the user an unpleasant odor due to the pungent odor peculiar to the wasabi component.
The odor having an odor intensity in the range of 2 to 3 exerts an effect of preventing mold and the like without causing discomfort to the user while the user feels a pungent odor peculiar to the wasabi component.

In the table of FIG. 5, in Example 1, the air permeability of the moisture-permeable film 2b is 30 sec / 100 cc, and the contents show the case of CD-AIT and calcium chloride. The odor of the dehumidifying agent of Example 1 was determined to be strong enough to detect the odor of AIT.

In Example 2, the air permeability of the moisture-permeable film 2b is 150 sec / 100 cc, and the contents show the case of CD-AIT and calcium chloride. The odor of the dehumidifying agent of Example 2 was determined to be strong enough to detect the odor of AIT.

In Example 3, the air permeability of the moisture-permeable film 2b is 400 sec / 100 cc, and the contents show the case of CD-AIT and calcium chloride. The odor of the dehumidifying agent of Example 3 was weakly perceived, but was determined to have a strength that was stably perceived over a long period of time.

In Example 4, the air permeability of the moisture-permeable film 2b is 1500 sec / 100 cc, and the contents show the case of CD-AIT and calcium chloride. The odor of the dehumidifying agent of Example 4 was weakly perceived, but was determined to have a strength that was stably perceived over a long period of time.

In Example 5, the air permeability of the moisture permeable film 2b is 8000 sec / 100 cc, and the contents show the case of CD-AIT and calcium chloride. The odor of the dehumidifying agent of Example 5 was weakly perceived, but was determined to have a strength that was stably perceived over a long period of time.

In Comparative Example 1, the air permeability of the moisture-permeable film 2b is 0 sec / 100 cc, and the contents show the case of CD-AIT and calcium chloride. The odor of the dehumidifying agent of Comparative Example 1 increased in intensity in a short period of time, and the odor of AIT was strongly perceived, but it was determined that the odor did not persist.

In Comparative Example 2, the air permeability of the moisture-permeable film 2b is 13000 sec / 100 cc, and the contents show the case of CD-AIT and calcium chloride. It was determined that the odor of the dehumidifying agent of Comparative Example 2 was hardly detected. Therefore, the dehumidifying agent of Comparative Example 2 does not have an antifungal effect or the like.

In Comparative Example 3, the air permeability of the moisture-permeable film 2b is 25000 sec / 100 cc, and the contents show the case of CD-AIT and calcium chloride. It was determined that the odor of the dehumidifying agent of Comparative Example 3 was hardly detected. Therefore, the dehumidifying agent of Comparative Example 3 does not have an antifungal effect or the like.

In Comparative Example 4, the air permeability of the moisture-permeable film 2b is 1500 sec / 100 cc, and the content is only CD-AIT. It was determined that the dehumidifying agent of Comparative Example 4 had no odor at all. In the case of Comparative Example 4, since there is no calcium chloride in the bag body 2, an aqueous solution of calcium chloride is not generated in the bag body 2. Therefore, since the inclusion force of the CD is stably included, the inclusion force is not weakened and the AIT is not released.

As described above, the amount of water vapor entering the bag body 2 is adjusted by using the moisture-permeable film 2b having an air permeability of 30 to 8000 sec / 100 cc. By adjusting the amount of water vapor that enters the bag 2, the amount of the aqueous solution of calcium chloride produced by the deliquescent property of calcium chloride is controlled. When the amount of the aqueous solution of calcium chloride is controlled, the amount of AIT released is adjusted within a predetermined range. As a result, the amount of AIT released is adjusted to a range in which an effect such as antifungal effect can be obtained and the user does not feel unpleasant odor.

In particular, when a moisture-permeable film 2b having a breathability of 400 to 8000 sec / 100 cc is used, the effect of antifungal and the like is exhibited for a long time.
Next, the result of testing the volatilization state of AIT when the ratio of the amount of CD-AIT and the amount of calcium chloride is changed will be described.

FIG. 7 shows the test results of the volatilization state of AIT when the ratio of the amount of CD-AIT and the amount of calcium chloride was changed. The table of FIG. 7 has items of the ratio of the amount of CD-AIT and the amount of calcium chloride, and the odor (effect). FIG. 8 is a graph showing the time change of the sensory evaluation result of FIG. 7.

The size of the ventilation surface of the moisture-permeable film 2b of the bag body 2 used in this test is 95 mm × 110 mm.
Here, a moisture permeable film 2b having an air permeability of 2200 sec / 100 cc is used.

Further, here, the amount of calcium chloride was adjusted with respect to 0.05 g (gram) of CD-AIT.
The air permeability was measured in accordance with P8117 of the Japanese Industrial Standards (JIS). For the measurement, a Wangken type aeration meter was used.

A mixture of CD-AIT and calcium chloride was hermetically sealed and contained in the bag 2 as a drug. These chemicals are housed in the bag body 2 having the size of the above-mentioned ventilation surface and sealed, and in a high humidity environment, where the room temperature is 25 ° C (25 degrees Celsius) and the relative humidity is 80%. Below, the volatilization status of AIT was confirmed by sensory evaluation.
In the evaluation, the odors of the seven subjects were evaluated on a six-point scale, and the average value of the seven subjects was used as the evaluation value. The numerical value of the odor intensity level in FIG. 8 is the same as the numerical value of the odor intensity level in FIG. 6 described above.

In the table, Example 6 shows the case where the ratio (weight ratio) of CD-AIT and calcium chloride is 1: 0.5. The odor of the dehumidifying agent of Example 6 was determined to be strong enough to feel the odor, although it took a long time.

Example 7 shows the case where the ratio of CD-AIT to calcium chloride is 1: 1. The odor of the dehumidifying agent of Example 7 was also determined to be strong enough to feel the odor, although it took time.
Example 8 shows the case where the ratio of CD-AIT to calcium chloride is 1: 5. The odor of the dehumidifying agent of Example 8 was determined to be strong enough to perceive the odor.

Example 9 shows the case where the ratio of CD-AIT to calcium chloride is 1:10. The odor of the dehumidifying agent of Example 9 was also determined to be strong enough to perceive the odor.
Example 10 shows the case where the ratio of CD-AIT to calcium chloride is 1:50. The odor of the dehumidifying agent of Example 10 was also determined to be strong enough to perceive the odor.

Example 11 shows the case where the ratio of CD-AIT to calcium chloride is 1: 100. The odor of the dehumidifying agent of Example 11 was also determined to be strong enough to perceive the odor.
Example 12 shows the case where the ratio of CD-AIT to calcium chloride is 1: 1000. The odor of the dehumidifying agent of Example 12 was also determined to be strong enough to perceive the odor.

Comparative Example 5 shows a case where the ratio of CD-AIT to calcium chloride is 1: 0. The odor of the dehumidifying agent of Comparative Example 5 was determined to be strong enough to not feel any odor.
From the above, in the ratio of CD-AIT to calcium chloride, even if the amount of calcium chloride is low, the odor is felt even if it takes a long time, so that it is considered that there is an effect such as antifungal effect.

Those having a small amount of calcium chloride shown in Examples 6 and 7 of FIG. 7 have a low dehumidifying effect, but can be used as a fungicide or acaricide. That is, the weight ratio of the component substance having the antifungal or anti-mite effect to the deliquescent substance is 0.5 to 1.

Also in FIG. 8, the odor having an odor intensity in the range of 1 to 2 is an odor intensity that exerts an effect such as antifungal effect without giving the user discomfort due to the pungent odor peculiar to the wasabi component.
The odor having an odor intensity in the range of 2 to 3 is an odor intensity that exerts an effect such as antifungal effect without causing discomfort to the user while the user feels a pungent odor peculiar to the wasabi component.

Therefore, in the cases of Examples 6 and 7 in which the amount of calcium chloride is small, the effect of antifungal and the like takes time until the effect is exhibited, but it occurs. In the cases of Examples 8 to 12, that is, when the ratio of CD-AIT to calcium chloride is from 1: 5 to 1: 1000, the antifungal effect is exhibited relatively quickly.

From FIG. 8, if the amount of calcium chloride is at least half the amount of CD-AIT, the dehumidifying agent 1 can produce an effect such as antifungal effect.
As described above, since the deliquescent substance is housed together with the CD-AIT in the bag having at least a part of the moisture-permeable sheet having a predetermined air permeability, it is generally possible to adjust the melting rate of the deliquescent substance. In a humidity environment in a storage space of a home, AIT can be released at a predetermined speed so that the user does not perceive an odor and can continuously obtain an effect such as antifungal effect.

In the above-described embodiment, the component substance encapsulated by cyclodextrin is AIT, but other component substances that are volatile at room temperature and have anti-mold and anti-tick effects. , For example, Timor, tea tree oil, eucalyptus oil, camphor, etc. may be used.

Further, in the above-described embodiment, the dehumidifying agent 1 having an effect of antifungal or the like has been described, but the above-mentioned preparation of the dehumidifying agent 1 may be used as an antifungal agent or an anti-mite agent. For example, the formulations of Examples 6 and 7 in the table shown in FIG. 7 can be used as an antifungal agent or an antifungal agent. Even in that case, a long-lasting effect can be obtained.

Furthermore, in the above-described embodiment, the dehumidifying agent is a bag body containing a deliquescent substance and CD-AIT together, but is a molded member of a non-moisture-permeable resin to which a moisture-permeable film is partially attached. It may be a type in which a deliquescent substance and a CD-AIT are housed together.

FIG. 9 is a block diagram of a dehumidifying agent using a molded member of a non-moisture permeable resin. The dehumidifier 1A of FIG. 9 is a dehumidifier in which a cyclodextrin inclusion substance and a deliquescent substance are housed in a container 11 of a molded member.
A partition plate 12 having a large number of small holes is provided in the internal space IS of the container 11 made of a non-breathable resin molded member. The container 11 is a non-breathable resin molding member having a bottomed portion and an opening at the upper portion.

A breathable film 2b having the above-mentioned air permeability is partially attached to the opening of the container 11.
CD-AIT3 and calcium chloride 4 are arranged on the upper part of the partition plate 12. That is, the CD-AIT 3 and the calcium chloride 4 are enclosed in the internal space IS of the container 11 which is a molding member of the non-moisture permeable resin to which the moisture permeable film 2b is partially attached, and are arranged on the upper part of the partition plate 12. To.

Calcium chloride 4, which is a deliquescent substance, absorbs water vapor through the moisture-permeable film 2b to produce an aqueous solution. The aqueous solution of the deliquescent substance collects in the internal space IS1 under the partition plate 12.
Therefore, the dehumidifying agent, the fungicide, or the mite-proofing agent may have the configuration shown in FIG.

The present invention is not limited to the above-described embodiment, and various changes, modifications, and the like can be made without changing the gist of the present invention.

1 Dehumidifying agent, 2 bags, 2a non-breathable film, 2b moisture-permeable film, 3 CD-AIT (allyl isothiocyanate encapsulated with cyclodextrin), 4 calcium chloride, 5 aqueous solution, 11 containers, 12 dividers.

Claims (8)

An enclosure having at least a portion of a breathable film having a breathability in the range of 1500-8000 sec / 100 cc.
The deliquescent substance sealed and stored in the containment body,
A cyclodextrin inclusion substance, which is a component substance having an antifungal or anti-mite effect, which is hermetically stored in the containing body.
Formulations with. The preparation according to claim 1 , wherein the component substance is allyl isothiocyanate. A dehumidifying agent having the formulation according to claim 1 or 2. The dehumidifying agent according to claim 3 , wherein the container is formed by laminating the moisture-permeable film and the non-moisture-permeable film. The dehumidifying agent according to claim 3 , wherein the container is a molded member of a non-moisture-permeable resin to which the moisture-permeable film is partially attached. The preparation according to claim 1, wherein the weight ratio of the deliquescent substance to the component substance is 0.5 to 1000. An antifungal agent having the formulation according to claim 6. An acaricide having the formulation according to claim 6.

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