JP6995142B2 - Guide wire - Google Patents

Description

The present invention relates to a medical guide wire.

Conventionally, various guide wires have been proposed for guiding a catheter or the like used by inserting it into a tubular organ such as a blood vessel, a digestive tract, or a ureter or an internal tissue for treatment or examination. For example, Patent Document 1 describes a guide wire having a coil-shaped contrast portion at the tip of the core material and a synthetic resin coating layer on the outer periphery of the core material and the contrast portion (see FIG. 1 and the like). Further, the surface of the synthetic resin coating layer described in Patent Document 1 is coated with a lubricating property.

Japanese Unexamined Patent Publication No. 2004-41254

The guide wire described in Patent Document 1 is provided with a coil body which is a contrast medium at the tip of the core material, and is provided with a synthetic resin coating layer on the outer periphery of the coil body. There was a problem that flexibility was impaired.

Further, in the guide wire described in Patent Document 1, the lubricating coating agent (hereinafter collectively referred to as “coating agent”) formed on the synthetic resin coating layer and its surface can be peeled off from the core material. Although the possibility of peeling has been slightly improved due to the anchor effect due to the high property and the outer diameter of the contrast medium being larger than the outer diameter of the core material (hereinafter referred to as "core shaft"), it is still not sufficient. rice field.

The present invention has been made in response to the above-mentioned problems of the prior art, and is capable of ensuring the flexibility of the tip of the guide wire and preventing the coating agent from peeling off from the core shaft or the like. The purpose is to provide wires.

In order to solve the above-mentioned problems, in the first aspect of the present invention, the core shaft, the coil body covering the core shaft, and the tip of the coil body are separated from the tip of the core shaft toward the proximal end side. The core shaft includes a first fixing portion to be fixed at a position, a coating agent for covering the core shaft , the coil body, and the outer periphery of the first fixing portion , and the core shaft has a tip from the first fixing portion. The core is provided with a bulge fixed at a position separated from the side, and the coating agent is applied from the tip end side of the tip end of the bulge portion to the base end side of the base end of the coil body, except for the inside of the coil body. It is characterized by covering the shaft , the coil body , the first fixing portion, and the bulging portion .

A second aspect of the present invention includes a core shaft, a twisted wire composed of a plurality of strands fixed to the tip of the core shaft and extending from the tip of the core shaft to the tip side, the core shaft, and the above. A coil body that covers the stranded wire, a first fixing portion that fixes the tip of the coil body in the middle of the stranded wire, and an outer circumference of the core shaft, the stranded wire, the coil body, and the first fixing portion. The stranded wire is provided with a bulge portion fixed at a position separated from the first fixing portion toward the tip end side, and the coating agent is used except for the inside of the coil body. It is characterized in that it covers the core shaft, the twisted wire , the coil body , the first fixing portion, and the bulging portion from the tip end side of the tip end of the bulging portion to the proximal end side of the proximal end of the coil body. ..

Further, a third aspect of the present invention is characterized in that, in the guide wire of the second aspect, the coating agent is inserted between the plurality of strands constituting the twisted wire.

According to the guide wire of the first aspect of the present invention, the core shaft, the coil body covering the core shaft, and the tip of the coil body are fixed at a position separated from the tip of the core shaft toward the proximal end side. The target is the one provided with the fixing portion of 1 and the coating agent covering the core shaft , the coil body and the outer periphery of the first fixing portion , and in particular, the core shaft is separated from the first fixing portion toward the tip side. A bulge portion fixed at a position is provided, and the coating agent is applied to the core shaft , the coil body , and the first fixing portion from the tip end side of the tip end of the bulge portion to the base end side of the base end of the coil body, except for the inside of the coil body. Since it covers the portion and the bulging portion , the flexibility of the coil body portion and the tip of the guide wire is ensured, and the bulging portion and the coil body prevent the coating agent from peeling from the core shaft and the coil body. Can be prevented.

Further, according to the guide wire of the second aspect of the present invention, the core shaft, a twisted wire composed of a plurality of strands fixed to the tip of the core shaft and extending from the tip of the core shaft to the tip side, and the core. A coating agent that covers the coil body that covers the shaft and the stranded wire, the first fixing portion that fixes the tip of the coil body in the middle of the stranded wire, and the outer periphery of the core shaft, the stranded wire, the coil body, and the first fixing portion. The stranded wire is provided with a bulge portion fixed at a position separated from the first fixing portion toward the tip end side, and the coating agent is applied from the tip end side of the tip end side of the bulge portion except for the inside of the coil body. Since the core shaft, stranded wire , coil body , first fixing portion and bulging portion are covered up to the proximal end side of the proximal end of the coil body, the coil body portion, the stranded wire portion, and the tip of the guide wire The flexibility can be further ensured, and the bulge and the coil body can prevent the coating agent from peeling off from the core shaft, the stranded wire and the coil body.

Further, according to the guide wire of the third aspect of the present invention, in the guide wire of the second aspect, since the coating agent has entered between the plurality of strands constituting the stranded wire, the coating agent is separated from the stranded wire. It can be further prevented from peeling off.

It is a schematic block diagram of the guide wire of 1st Embodiment of this invention. It is a vertical sectional view of the guide wire of 1st Embodiment. It is a schematic block diagram of the guide wire of 2nd Embodiment. It is a vertical sectional view of the guide wire of 2nd Embodiment. It is a vertical sectional view of the tip part of the guide wire of 3rd Embodiment. It is a vertical sectional view in the vicinity of the stranded wire of the guide wire of the 3rd embodiment.

Hereinafter, embodiments of the present invention will be described with reference to the drawings.

(First Embodiment)
First, the first embodiment of the present invention will be described.
FIG. 1 is a schematic configuration diagram of a guide wire according to the first embodiment of the present invention, and FIG. 2 is a vertical sectional view of the guide wire according to the first embodiment.

As shown in FIG. 1, the guide wire 1 of the present embodiment includes a core shaft 3, a coil body 5 whose tip is fixed at a position separated from the tip of the core shaft 3 toward the proximal end side, and a coil in the core shaft 3. It is composed of a bulging portion 9 fixed at a position separated from the tip of the body 5 toward the tip side, and a coating agent 7 covering the outer periphery of the core shaft 3, the coil body 5, and the bulging portion 9.

The core shaft 3 is a rod-shaped member having a circular cross section whose diameter is reduced from the base end to the tip end, and is a long flexible member. The material of the core shaft 3 is not particularly limited as long as it is a biocompatible material such as stainless steel, Ni—Ti alloy, cobalt-based alloy, etc., but stainless steel is used in this embodiment.

The tip of the coil body 5 is fixed at a position separated from the tip of the core shaft 3 toward the proximal end side. Specifically, the tip of the coil body 5 is fixed to the core shaft 3 by the brazing material 2, and the base end of the coil body 5 is fixed to the core shaft 3 by the brazing material 4.

The brazing material 2 and the brazing material 4 are not particularly limited as long as they are biocompatible brazing materials such as gold tin brazing material and silver tin brazing material, but the silver tin brazing material is used in the present embodiment. .. Further, the coil body 5 is a cylindrical hollow coil body formed by winding a single or a plurality of metal strands, and the outer diameter thereof is larger than the outer diameter of the core shaft 3 at the position where the coil body 5 is fixed. Is also big.

The material of the metal wire forming the coil body 5 is not particularly limited as long as it is a biocompatible material such as stainless steel, tungsten, Ni—Ti alloy, etc., but stainless steel is used in this embodiment. ..

The bulging portion 9 is fixed to the tip of the core shaft 3 at a position separated from the tip of the coil body 5 toward the tip side, and its outer diameter is outside the core shaft 3 at the position where the bulging portion 9 is fixed. Larger than the diameter. As the material of the bulging portion 9, the brazing material 2 to which the coil body 5 is fixed and the same brazing material as the brazing material 4 are generally used.

The area of the coating agent 7 is shown by diagonal lines in FIG. 2, but as shown in FIG. 2, the coil body is formed from the tip of the guide wire 1 which is the tip end side of the bulging portion 9 except for the inside of the coil body 5. The core shaft 3, the coil body 5, and the bulging portion 9 are covered up to the proximal end side of the proximal end of 5.

The reason why the coating agent 7 does not penetrate into the coil body 5 is to ensure the flexibility of the tip of the guide wire 1.

The coating agent 7 of the present embodiment covers the core shaft 3 up to the base end of the core shaft 3 even on the base end side of the base end of the coil body 5 in order to reduce the frictional resistance of the guide wire 1. ..

The coating agent 7 is preferably formed of a material having a low frictional resistance, for example, polyvinyl alcohol, polyvinylpyrrolidone, polyethylene glycol, polyacrylamide, polyacrylic acid, sodium polyacrylate, poly (2-hydroxyethyl methacrylate), and anhydrous. Maleic acid-based copolymer, ethylene vinyl alcohol copolymer, 2-methacryloyloxyethyl phosphorylcholine or its copolymer, (2-hydroxyethylmethacrylate) -styrene block copolymer, various synthetic polypeptides, collagen, hyaluronic acid, It is desirable to use a cellulose-based polymer and a mixture thereof.

Further, the coating agent 7 may be made of a different material depending on the position of the guide wire 1. For example, a coating agent 7 made of different materials from the intermediate position of the coil body 5 to the region on the distal end side and the region on the proximal end side may be adopted.

According to the guide wire 1 of the present embodiment, the core shaft 3, the coil body 5 whose tip is fixed at a position separated from the tip of the core shaft 3 toward the proximal end side, and the outer periphery of the core shaft 3 and the coil body 5 The core shaft 3 includes a bulging portion 9 fixed to a position separated from the tip end side of the coil body 5, and the coating agent 7 bulges except for the inside of the coil body 5. Since the core shaft 3 and the coil body 5 are covered from the tip end side of the portion 9 to the base end side of the base end of the coil body 5, the flexibility of the coil body 5 and, by extension, the tip end portion of the guide wire 1 is ensured. The bulging portion 9 and the coil body 5 can prevent the coating agent 7 from peeling off from the core shaft 3 and the coil body 5.

The bulging portion 9 may be fixed to the tip of the core shaft 3 so that the tip of the core shaft 3 does not protrude from the bulging portion 9. According to this configuration, it is possible to prevent the tip of the core shaft 3 from jumping out of the coating agent 7 and damaging internal tissues.

(Second Embodiment)
Next, a second embodiment of the present invention will be described.
FIG. 3 is a schematic configuration diagram of the guide wire of the second embodiment, and FIG. 4 is a vertical sectional view of the guide wire of the second embodiment.

As shown in FIG. 3, the guide wire 10 of the present embodiment is composed of a core shaft 13 and a plurality of strands fixed to the tip of the core shaft 13 so as to be located on the tip side of the core shaft 13. The stranded wire 16, the coil body 15 whose tip is fixed at a position separated from the tip of the stranded wire 16 toward the proximal end side, and the proximal end is fixed to the core shaft 13, and the stranded wire 16, the core shaft 13, and the coil body 15. It is composed of a coating agent 17 that covers the outer periphery of the coil body 16 and a bulging portion 19 that is fixed to the stranded wire 16 at a position separated from the tip end side of the coil body 15.

Like the core shaft 3, the core shaft 13 is a rod-shaped member having a circular cross section whose diameter is reduced from the base end to the tip end, and is a long flexible member. The material thereof is the same as that of the core shaft 3.

As shown in FIG. 4, the base end of the stranded wire 16 is fixed to the tip end portion of the core shaft 13 by a brazing material 18 inside the coil body 15, and the stranded wire 16 is fixed from the tip end of the core shaft 13 and the tip end of the coil body 15. It extends to the tip side.

The stranded wire 16 may be fixed not only to the core shaft 13 but also to the coil body 15 by the brazing material 18.

The tip of the coil body 15 is fixed to the stranded wire 16, and the base end thereof is fixed to the core shaft 13. Specifically, the tip of the coil body 15 is fixed to the twisted wire 16 by the brazing material 12, and the base end of the coil body 15 is fixed to the core shaft 13 by the brazing material 14.

As the brazing material 12, the brazing material 14, and the brazing material 18, the same materials as the brazing material 2 and the brazing material 4 of the first embodiment can be used. Further, the coil body 15 is the same as the coil body 5 of the first embodiment, and its outer diameter is larger than the outer diameter of the core shaft 13 at the position where the coil body 15 is fixed.

The bulging portion 19 is fixed to the stranded wire 16 at a position separated from the tip of the core shaft 13 and the tip of the coil body 15 toward the tip side, and the outer diameter thereof is the core shaft at the position where the bulging portion 19 is fixed. It is larger than the outer diameter of 13. The material of the bulging portion 19 is the same as that of the bulging portion 9 of the first embodiment.

The area of the coating agent 17 is shown by diagonal lines in FIG. 4, but as shown in FIG. 4, the coil body is formed from the tip of the guide wire 10 on the tip side of the bulging portion 19 except for the inside of the coil body 15. The core shaft 13, the coil body 15, and the bulging portion 19 are covered up to the proximal end side of the proximal end of 15.

The reason why the coating agent 17 does not penetrate into the coil body 15 is to ensure the flexibility of the tip of the guide wire 10 as in the first embodiment.

The coating agent 17 of the present embodiment covers the core shaft 13 up to the base end of the core shaft 13 even on the base end side of the base end of the coil body 15. The material of the coating agent 17 is the same as that of the coating agent 7 of the first embodiment.

According to the guide wire 2 of the present embodiment, the core shaft 13, a twisted wire 16 composed of a plurality of strands fixed to the tip of the core shaft 13 so as to be located on the tip side of the core shaft 13, and the tip thereof. Is fixed at a position separated from the tip of the stranded wire 16 toward the proximal end side, and the coating agent covering the coil body 15 whose proximal end is fixed to the core shaft 13 and the outer periphery of the stranded wire 16, the core shaft 13, and the coil body 15. 17 and a bulging portion 19 fixed to the tip side of the coil body 15 from the tip end side of the stranded wire 16 are provided, and the coating agent 17 is applied to the coil body 15 from the tip end side of the bulging portion 19 except for the inside of the coil body 15. Since the core shaft 13 and the coil body 15 are covered up to the base end side of the base end, the flexibility of the coil body 15 and the tip portion of the guide wire 10 is ensured, and the bulging portion 19 and the coil body 15 are used. , The coating agent 17 can be prevented from peeling from the stranded wire 16, the core shaft 13 and the coil body 15.

The bulging portion 19 may be fixed to the tip of the stranded wire 16 so that the tip of the stranded wire 16 does not protrude from the bulging portion 19. According to this configuration, it is possible to prevent the tip of the stranded wire 16 from jumping out of the coating agent 17 and damaging the internal tissue.

(Third Embodiment)
Next, a third embodiment of the present invention will be described.
FIG. 5 is a vertical cross-sectional view of the tip end portion of the guide wire of the third embodiment, and FIG. 6 is a vertical cross-sectional view of the vicinity of the stranded wire of the guide wire of the third embodiment.

In the present embodiment, the same members as those in the second embodiment are assigned the same numbers, and the description thereof will be omitted.

The guide wire 20 of the present embodiment is different from the guide wire 10 of the second embodiment in the adhered state between the stranded wire and the coating agent. That is, the coating agent 27 enters between the plurality of strands constituting the stranded wire 26 and forms a protruding portion 27a protruding from the gap between the plurality of strands constituting the stranded wire 26.

The guide wire of the present embodiment increases the adhesion strength between the coating agent 27 and the stranded wire 26 by forming the protruding portion 27a. Further, the protruding portion 27a of the present embodiment has an outer diameter larger than the distance between the strands at the lower portion between the strands constituting the strands 26, and the coating agent 27 is peeled from the strands 26. It is further prevented from doing so.

As shown in FIG. 5, the base end of the stranded wire 26 is fixed to the tip end portion of the core shaft 13 by a brazing material 28 inside the coil body 15, and the stranded wire 26 is fixed from the tip end of the core shaft 13 and the tip end of the coil body 15. It extends to the tip side. As the brazing material 28, the same materials as the brazing material 2 and the brazing material 4 of the first embodiment can be used.

According to the guide wire 20 of the present embodiment, as compared with the guide wire 10 of the second embodiment, the coating agent 27 is inserted between the plurality of strands constituting the stranded wire 26, so that the coating agent 27 is twisted. It is possible to further prevent the wire 26 from peeling off.

The bulging portion 19 may be fixed to the tip of the stranded wire 26 so that the tip of the stranded wire 26 does not protrude from the bulging portion 19. According to this configuration, it is possible to prevent the tip of the stranded wire 26 from jumping out of the coating agent 27 and damaging the internal tissue.

1,10,20 ... Guide wire 2,4,12,14,18,28 ... Row material 3,13 ... Core shaft 5,15 ... Coil body 7,17,27 ... Coating agent 9, 19 ... Bulging part 16, 26 ... Twisted wire 27a ... Protruding part

Claims (3)

With the core shaft
The coil body that covers the core shaft and
A first fixing portion for fixing the tip of the coil body at a position separated from the tip of the core shaft toward the base end side,
A coating agent that covers the outer periphery of the core shaft , the coil body, and the first fixing portion , and
Equipped with
The core shaft includes a bulge portion fixed at a position separated from the first fixing portion toward the tip end side.
The coating agent comprises the core shaft , the coil body , the first fixing portion, and the coating agent from the tip end side of the tip end of the bulge portion to the proximal end side of the base end of the coil body, except for the inside of the coil body. A guide wire characterized by covering the bulge . With the core shaft
A twisted wire consisting of a plurality of strands fixed to the tip of the core shaft and extending from the tip of the core shaft to the tip side ,
The coil body that covers the core shaft and the stranded wire, and
A first fixing portion for fixing the tip of the coil body in the middle of the twisted wire, and
A coating agent that covers the outer periphery of the core shaft, the twisted wire, the coil body, and the first fixing portion.
Equipped with
The stranded wire has a bulge portion fixed at a position separated from the first fixing portion toward the tip end side.
The coating agent is the core shaft, the twisted wire , the coil body , and the first first, except for the inside of the coil body, from the tip end side of the tip of the bulge to the proximal end side of the proximal end of the coil body. A guide wire characterized by covering the fixed portion and the bulging portion . The guide wire according to claim 2, wherein the coating agent penetrates between the plurality of strands constituting the stranded wire.

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