JP7025762B2 - Cleaning disinfectant composition - Google Patents

Description

The present invention mainly relates to a cleaning sterilizing agent composition used for cleaning and sterilizing appliances and equipment of food factories and the like and boots of workers' fingers and stepping tanks.

From the viewpoint of hygiene, it is necessary to clean and disinfect floors, walls, utensils, equipment, etc. at sites that handle food such as food factories, kitchens such as restaurants, and processing workshops in supermarkets. Various disinfectants such as system compounds, peroxides, and cationic surfactants are used.

However, the disinfectant composition consisting of an aqueous solution containing a cationic surfactant has a disinfecting power but does not have a sufficient detergency, and in order to enhance the detergency, a normal cleaning agent such as an anionic ion is used. It is known that when a surfactant is used in combination, its bactericidal efficacy is significantly reduced. Therefore, in hospitals, food factories, etc., there is a problem that cleaning and sterilization must be performed in two steps. Further, the cationic surfactant has a problem that sliminess and stickiness tend to remain after use, and it takes time and effort to rinse.

In Patent Document 1, cleaning and sterilization are performed by using an aqueous solution containing a dilong-chain alkyldi-short-chain alkylammonium salt, an amphoteric surfactant, polyoxyethylene oxypropylene alkyl ether and ethanol in a specific ratio. A sterilizing detergent composition that can be used in the above has been proposed.

However, the di-long-chain alkyl di-short-chain alkylammonium salt represented by didecyldimethylammonium chloride has metal corrosiveness, and corrosion such as rust may occur depending on the equipment and appliances such as food factories. In addition, didecyldimethylammonium chloride tends to remain slimy after use, and it may take time and effort to rinse. Furthermore, the di-long-chain alkyl-di-short-chain alkylammonium salt may have an insufficient bactericidal effect on fungi such as mold.

Patent Document 2 proposes a disinfectant composition containing biguanides and a quaternary ammonium salt in a specific weight ratio.

However, biguanides such as polyhexamethylene biguanide hydrochloride tend to remain sticky after use, and also have a problem that rinsing takes time and effort.

Furthermore, industrial cleaning disinfectants are often colored by adding a dye to prevent misuse or accidental ingestion, such as didecyldimethylammonium chloride and polyhexamethylene biguanide hydrochloride. In the cleaning disinfectant containing the cationic surfactant of the above, discoloration may occur especially when stored at a high temperature.

From the above background, a cleaning sterilizing agent composition that can achieve cleaning and sterilization at the same time, has excellent rinsing properties, and suppresses discoloration during storage has been desired.

Japanese Patent No. 4468010 Special Table 2012-521434 Gazette

An object of the present invention is to provide a cleaning sterilizing agent composition which can achieve cleaning and sterilization at the same time, has excellent rinsing properties, and suppresses discoloration during storage.

As a result of diligent studies, the present inventors solve the above-mentioned problems with a composition containing two or more specific cationic surfactants and two or more specific nonionic surfactants in a specific amount ratio. This led to the completion of the present invention.

That is, the present invention
(A-1) One or more compounds selected from the group consisting of polyhexamethylene biguanide hydrochloride, polyhexamethylene guanidine phosphate, polyhexamethylene guanidine hydrochloride, and polyaminopropyl biguanide hydrochloride, and (A-2). (A) Cationic surfactant consisting of one or more di-long-chain alkyl-di-short-chain alkylammonium methyl sulfates, and (B-1) one or more polyoxys having an HLB value of 10.5-12.5. It contains (B) a nonionic surfactant consisting of an alkylene alkyl ether and (B-2) one or more polyoxyalkylene alkyl ethers having an HLB value of 13.0 to 15.0.
The weight ratio of (A) and (B) is 1: 0.5 to 1: 1.5, and the pH when a 1% by weight aqueous solution is prepared is 2.5 to 5 for washing and sterilization. The agent composition is provided.

Further, the present invention
(A-1) One or more compounds selected from the group consisting of polyhexamethylene biguanide hydrochloride, polyhexamethylene guanidine phosphate, polyhexamethylene guanidine hydrochloride, and polyaminopropyl biguanide hydrochloride, and (A-2). (A) Cationic surfactant consisting of one or more di-long-chain alkyl-di-short-chain alkylammonium methyl sulfates, and (B-1) one or more polyoxys having an HLB value of 10.5-12.5. It contains (B) a nonionic surfactant consisting of an alkylene alkyl ether and (B-2) one or more polyoxyalkylene alkyl ethers having an HLB value of 13.0 to 15.0.
The weight ratio of (A) and (B) is 1: 0.5 to 1: 1.5, and the pH when a 1% by weight aqueous solution is prepared is 2.5 to 5 for washing and sterilization. A method for producing an agent composition, which is a method for producing an agent composition.
Also provided is a method comprising (A) dissolving the (B) nonionic surfactant heated to a temperature of 35-45 ° C. in the cationic surfactant.

The (A) cationic surfactant used in the present invention is selected from one or more selected from (A-1) compounds and (A-2) di-long-chain alkyl di-short-chain alkylammonium methyl sulfate 1. Consists of more than seeds.

The (A-1) compound is one or more compounds selected from the group consisting of polyhexamethylene biguanide hydrochloride, polyhexamethylene guanidine phosphate, polyhexamethylene guanidine hydrochloride, and polyaminopropyl biguanide hydrochloride. Polyhexamethylene biguanide hydrochloride is preferred because it has a broad antibacterial spectrum and is easily available.

The degree of polymerization of the compound (A-1) is not particularly limited, but for example, a compound having a degree of polymerization of 6 to 18 is preferably used.

（式中Ｒ_１およびＲ_２は、同一または異なってよく、分岐を有していてもよい飽和または不飽和の長鎖アルキル基を示し、Ｒ_３およびＲ_４は、同一または異なってよい、短鎖アルキル基を示す。） (A-2) Examples of the di-long-chain alkyl-di-short-chain alkylammonium methyl sulfate include a quaternary ammonium salt represented by the following general formula (1).

(In the formula, R ₁ and R ₂ may be the same or different, indicating saturated or unsaturated long chain alkyl groups which may have a branch, and R ₃ and R ₄ may be the same or different, short. Indicates a chain alkyl group.)

The long-chain alkyl group represented by R ₁ and R ₂ is preferably an alkyl group having 8 to 18 carbon atoms, for example, 2-ethylhexyl, octyl, decyl, dodecyl, stearyl and the like, but particularly preferably 8 to 10 carbon atoms. It is an alkyl group. Methyl or ethyl groups are suitable for R ₃ and R ₄ , and methyl is particularly preferable.

Specific examples of the dilong-chain alkyl dishort-chain alkylammonium methyl sulfate include dioctyldimethylammonium methyl sulfate, octyldecyldimethylammonium methyl sulfate, and didecyldimethylammonium methyl sulfate.
Didecyldimethylammonium methyl sulfate is preferable because it is less likely to cause turbidity or separation when combined with the above component (A-1), and is less likely to cause discoloration when the cleaning disinfectant composition is colored. ..

In the (A) cationic surfactant, the weight ratio of (A-1) to (A-2) is the compound of (A-1) to be selected and the dilong-chain alkyldi-short-chain alkylammonium of (A-2). It may vary depending on the type and number of methyl sulfates, but for example, when (A-1) polyhexamethylene biguanide hydrochloride and (A-2) didecyldimethylammonium methyl sulfate are selected, 1: 2.5 to It is preferably 1: 5.5, more preferably 1: 3 to 1: 5, and even more preferably 1: 3.5 to 1: 4.5.

The ratio of the (A) cationic surfactant in the cleaning / disinfecting agent composition of the present invention is not particularly limited as long as it does not cause turbidity or separation during mixing or storage, but the total amount of the cleaning / disinfecting agent composition. The total amount of the cationic surfactant is preferably 5 to 30% by weight, more preferably 8 to 28% by weight, still more preferably 10 to 25% by weight. If the total amount of cationic surfactant is less than 5% by weight based on the total amount of the cleaning disinfectant composition, the disinfecting effect tends to be insufficient, and 30% by weight based on the total amount of the cleaning disinfectant composition. If it exceeds, turbidity and separation tend to occur during mixing or storage.

Further, the (B) nonionic surfactant used in the present invention is (B-1) one or more selected from polyoxyalkylene alkyl ethers having an HLB value of 10.5 to 12.5, and (B-2). ) Consists of one or more selected from polyoxyalkylene alkyl ethers having an HLB value of 13.0 to 15.0.

(B-1) Examples of the polyoxyalkylene alkyl ether having an HLB value of 10.5 to 12.5 include Sannonic FN-80, Cedran FF-180, and Naroacty CL-70 (all manufactured by Sanyo Chemical Industries, Ltd.). , Emargen 106, Emargen 108, Emargen 210, Emargen 409P (above, manufactured by Kao Corporation), Finesurf D-1305, Safety Cut ND-2033, Blaunon CH-308 (above, manufactured by Aoki Oil & Fat Industry Co., Ltd.). .. The cloud point of the 2% by weight aqueous solution is preferably 20 to 50 ° C, more preferably 25 to 45 ° C, still more preferably 30 to 40 ° C, in that turbidity and separation are unlikely to occur during mixing. ..

(B-2) Examples of the polyoxyalkylene alkyl ether having an HLB value of 13.0 to 15.0 include Sannonic FN-140, Cedran FF-220, and Naroacty CL-120 (all manufactured by Sanyo Chemical Industries, Ltd.). , Emalgen 109P, Emalgen 220, Emalgen 320P, Emalgen LS-110 (all manufactured by Kao Corporation), Blaunon EL-1509, Blaunon CH-315L, Blaunon EN-1513.5, Blaunon EN914, Safety Cut LI-3085, Fine Surf D-85 (all manufactured by Aoki Oil & Fat Industry Co., Ltd.) can be mentioned. The cloud point of the 2 wt% aqueous solution is preferably 65 to 95 ° C., more preferably 70 to 90 ° C., and even more preferably 75 to 85 ° C. in that turbidity and separation are unlikely to occur during mixing. ..

In the (B) nonionic surfactant, the weight ratio of (B-1) to (B-2) may vary depending on the type and number of polyoxyalkylene alkyl ethers selected, eg, (B-1) HLB. When a polyoxyalkylene alkyl ether having a value of 11.7 and a cloud point of 34 ° C. and a (B-2) polyoxyalkylene alkyl ether having an HLB value of 13.9 and a cloud point of 81 ° C. are selected, It is preferably 1: 0.1 to 1: 6, more preferably 1: 0.5 to 1: 5, and even more preferably 1: 0.8 to 1: 4.

The ratio of the (B) nonionic surfactant in the cleaning / disinfecting agent composition of the present invention is not particularly limited as long as it does not cause turbidity or separation during mixing or storage, but the total amount of the cleaning / disinfecting agent composition. The total amount of the nonionic surfactant is preferably 3 to 30% by weight, more preferably 5 to 25% by weight, still more preferably 8 to 22% by weight. If the total amount of nonionic surfactant is less than 3% by weight based on the total amount of the cleaning disinfectant composition, the cleaning effect tends to be insufficient, and 30% by weight is added to the total amount of the cleaning disinfectant composition. If it exceeds, the viscosity tends to increase and the stickiness tends to increase.

The weight ratio of (A) cationic surfactant and (B) nonionic surfactant in the cleaning and disinfecting agent composition of the present invention may be 1: 0.5 to 1: 1.5, and 1: It is preferably 0.7 to 1: 1.3, more preferably 1: 0.8 to 1: 1.2. If the weight of (B) nonionic surfactant is less than 0.5 times the weight of (A) cationic surfactant, separation and turbidity tend to occur during storage, which is 1.5 times. If the amount is exceeded, the sterilizing effect tends to be insufficient.

In the cleaning and disinfecting agent composition of the present invention, the pH at the time of preparing a 1 wt% aqueous solution may be 2.5 to 5, preferably 3 to 4.5, and 3.5 to 4 is preferable. It is more preferable to have it. If the pH of the 1 wt% aqueous solution is less than 2.5, there is a tendency for metal products to corrode, and if the pH exceeds 5, the dye added to prevent misuse or accidental ingestion. Tends to fade.

The cleaning and disinfecting agent composition of the present invention may be adjusted by using various pH adjusting agents so that the pH at the time of preparing a 1% by weight aqueous solution is 2.5 to 5. The pH adjuster is not particularly limited as long as it does not affect the cleaning effect, the sterilizing effect, the storage stability, the fading suppressing effect, and the like, and examples thereof include sodium hydroxide and potassium hydroxide.

The cleaning disinfectant composition of the present invention may further contain ethanol in addition to the above components. The inclusion of ethanol tends to improve the stability of the cleaning disinfectant composition. As ethanol, either industrial ethanol or denatured alcohol can be used. The proportion of ethanol is preferably 15% by weight or less, more preferably 0.5 to 10% by weight, still more preferably 1 to 5% by weight, based on the total weight of the cleaning disinfectant composition. It is not preferable to add 10% by weight or more of ethanol because the cleaning disinfectant composition becomes cloudy.

Other additives that can be contained as needed include, for example, organic metal ion sequestering agents such as ethylenediaminetetraacetate (EDTA), N-hydroxyethyl-ethylenediaminetriacetate (HEDTA), and triethanolamine, and tar-based dyes. , Colorants and fragrances such as triphenylmethane dyes (blue No. 1, green No. 3), azo dyes (yellow No. 4, yellow No. 5, red No. 2, red No. 102) and the like. The proportion of these other additives is usually 2.5% by weight or less based on the total weight of the cleaning disinfectant composition.

The cleaning and disinfecting agent composition of the present invention comprises (A) a cationic surfactant and (B) a nonionic surfactant heated to 35 to 45 ° C. from 1: 0.5 to 1: 1.5. It can be manufactured by mixing in a weight ratio of. (B) The temperature at which the nonionic surfactant is heated is preferably 37 to 43 ° C, more preferably 39 to 41 ° C.

The cleaning sterilizing agent composition thus obtained can be used for various objects requiring cleaning and sterilization after cooling at room temperature. Regarding the method of application to the object, the obtained cleaning disinfectant composition may be brought into direct contact with the object, or if necessary, the composition may be diluted with water and then brought into contact with the object. May be good. The method of contacting the object includes, but is not limited to, spray addition, mixing, coating, and dipping.

The cleaning and disinfecting agent composition of the present invention can be used without dilution, but usually, a 0.3 to 30% by weight aqueous solution is prepared and used at the time of use.

The cleaning and disinfecting agent composition of the present invention is useful as an environmental cleaning and disinfecting agent for cleaning and disinfecting floors and walls of food factories, barns, hotels, restaurants, schools, stores, hospitals and the like.
It is also useful for cleaning and sterilizing food manufacturing / processing equipment and utensils used in food factories and the like. Examples of food manufacturing / processing equipment include various stirrers, mixers, homogenizers, automatic cutters, and the like. Examples of the utensil include a cutting board, a kitchen knife, a food container, a cloth, and the like.

The cleaning and disinfecting agent composition of the present invention does not cause turbidity or separation even when stored for a long period of time, and its liquid property is stable.

Hereinafter, the present invention will be further described with reference to Examples.

Example 1 and Comparative Example 1
(Stability test 1 (dissolved state); method)
The cleaning and disinfecting agent compositions I to III of the present invention having the compositions shown in Table 1-1 are dissolved in (A) a cationic surfactant and (B) a nonionic surfactant heated to a temperature of 40 ° C. The solution was visually observed immediately after mixing and after storage for 1 week (Example 1). Further, as a comparative example, the compositions IV to IX shown in Table 1-2 were prepared in the same manner as in Example 1 and observed in the same manner as in Example 1 (Comparative Example 1). The temperature at the time of storage was 0 ° C. and 45 ° C., and for those separated immediately after mixing or during storage, the test was stopped at the time of separation, and no further observation was performed. The cationic surfactants 1 to 5 and the nonionic surfactants 1 and 2 used in Examples and Comparative Examples are as follows. In addition, the numerical values in the table represent weight%.

Cationic Surfactant 1: Polyhexamethylene Biguanide Hydrochloride Cationic Surfactant 2: Didecyldimethylammonium Methyl Sulfate Cationic Surfactant 3: Didecylmethylpolyoxyethylammonium Propionate Cationic Surfactant 4 : Didecyldimethylammonium adipate cationic surfactant 5: Didecyldimethylammonium hydrochloride Nonionic surfactant 1: Polyoxyalkylene alkyl ether (HLB value = 11.7, cloud point = 34 ° C.)
Nonionic surfactant 2: Polyoxyalkylene alkyl ether (HLB value = 13.9, cloud point = 81 ° C.)

(Stability test 1 (dissolved state); result)
The results are shown in Table 1-1 and Table 1-2. The cleaning and disinfecting agent compositions I to III of the present invention and VII to IX in Comparative Examples were stable without causing separation or the like from the time of mixing to after storage for 1 week. Moreover, in the comparative example, VI was separated at the time of mixing. IV and V were good at the time of mixing, but became unstable at the time of storage and separated. In the table, "◯" indicates that separation and turbidity were not observed, and "x" indicates that separation and turbidity were observed.

Example 2 and Comparative Example 2
(Stability test 2 (fading); method)
With respect to the cleaning disinfectant compositions I to III of the present invention prepared in Example 1, the degree of fading after storage for 1 week and 4 weeks was visually observed (Example 2). Further, the compositions IV to IX prepared in Comparative Example 1 were also observed in the same manner as in Example 2 (Comparative Example 2).

(Stability test 2 (fading); result)
The results are shown in Table 1-1 and Table 1-2. The cleaning and disinfecting agent compositions I to III of the present invention were stable without causing discoloration until after storage for 4 weeks. In the comparative examples, fading was observed for IV, V, VIII and IX after storage for 1 week (45 ° C) and for VII after storage for 4 weeks (45 ° C). In the table, "○" indicates that no fading was observed, and "x" indicates that fading was observed.

(Rinseability test; method)
The cleaning and disinfecting agent compositions I to III of the present invention prepared in Example 1 were each diluted with water to a concentration of 5% to prepare a diluted solution. After immersing about 3 cm of the lower part of the metal piece (SUS403: 30 × 50 mm) in the prepared diluted solution, the liquid was drained and placed upright in an empty beaker. The beaker was wrapped and covered, and left overnight at room temperature, and then the metal pieces were washed with running water for 3 seconds. With respect to the treated metal pieces, the concentration of the residual composition on the surface was evaluated according to the following evaluation criteria using a concentration confirmation test paper (Vantocil Test Strips). Further, the compositions IV to IX prepared in Comparative Example 1 were also evaluated in the same manner.

<Evaluation criteria>
◯: Less than 3 ppm ×: 3 ppm or more

(Rinseability test; result)
The results are shown in Table 1-1 and Table 1-2. In the test using the cleaning and disinfecting agent compositions I to III of the present invention, the concentration of the residual composition was low and good rinsability was shown. Moreover, in the test using V to VII and IX in the comparative example, the residue of the composition was confirmed.

Example 3
(Bactericidal power test; method)
The test bacteria shown below were cultured in BHI (Brain Heart Infusion) bouillon medium at 30 ° C. for 24 hours, and the bacterial solution was diluted 10-fold with physiological saline, and the cleaning disinfectant composition I was expressed in water. After adding 0.1 ml to 10 ml of the solution diluted to the concentrations shown in 2 to 4 and stirring, the mixture was held at 20 ° C. for 0.5, 1.0 and 3.0 minutes. After stirring again after the sensitization time, one loopful was taken from each mixture and inoculated into 10 ml of BHI bouillon medium. This was cultured at 30 ° C. for 48 hours. Using a BHI bouillon medium uninoculated with bacteria as a control, the turbidity of the medium was visually compared to determine the sterilizing effect of the washing sterilizing agent composition I on each cell.

Test bacteria:
Escherichia coli NIHJ JC-2
Bacillus subtilis IAM1069
Mold ( Penicillium citrinum NFRI-1019)

(Bactericidal activity test; result)
The results are shown in Tables 2-4. In the table, "-" indicates that the sterilizing effect was confirmed, and "+" indicates that the sterilizing effect was not confirmed. The concentration in the table represents the concentration of the cleaning disinfectant composition I.

（薬剤接触時菌量：８．３×１０^４ＣＦＵ／ｍＬ）

(Amount of bacteria at the time of drug contact: 8.3 × 10 ⁴ CFU / mL)

（薬剤接触時菌量：０．９×１０^５ＣＦＵ／ｍＬ）

(Amount of bacteria at the time of drug contact: 0.9 × ¹⁰⁵ CFU / mL)

（薬剤接触時菌量：１．６×１０^４ＣＦＵ／ｍＬ）

(Amount of bacteria at the time of drug contact: 1.6 × 10 ⁴ CFU / mL)

Claims (9)

(A-1) One or more compounds selected from the group consisting of polyhexamethylene biguanide hydrochloride, polyhexamethylene guanidine phosphate, polyhexamethylene guanidine hydrochloride, and polyaminopropyl biguanide hydrochloride, and (A-2). (A) Cationic surfactant consisting of one or more di-long-chain alkyl-di-short-chain alkylammonium methyl sulfates, and (B-1) one or more polyoxys having an HLB value of 10.5-12.5. It contains (B) a nonionic surfactant consisting of an alkylene alkyl ether and (B-2) one or more polyoxyalkylene alkyl ethers having an HLB value of 13.0 to 15.0.
The weight ratio of (A) and (B) is 1: 0.5 to 1: 1.5, and the pH when a 1% by weight aqueous solution is prepared is 2.5 to 5 for washing and sterilization. Agent composition. The total amount of (A) cationic surfactant to the total amount of the cleaning disinfectant composition is 5 to 30% by weight, and the total amount of (B) nonionic surfactant to the total amount of the cleaning disinfectant composition is 3 to 30% by weight. The cleaning disinfectant composition according to claim 1, which is 30% by weight. (A-1) The cleaning disinfectant composition according to claim 1 or 2, wherein the compound is polyhexamethylene biguanide hydrochloride. (A-2) The cleaning sterilizing agent composition according to any one of claims 1 to 3, wherein the di-long-chain alkyl-di-short-chain alkylammonium-methylsulfate is didecyldimethylammonium-methylsulfate. The cleaning disinfectant composition according to any one of claims 1 to 4, wherein the weight ratio of (A-1) and (A-2) is 1: 2.5 to 1: 5.5. The cleaning disinfectant composition according to any one of claims 1 to 5, wherein the cloud point of (B-1) is 20 to 50 ° C. (2 wt% aqueous solution). The cleaning disinfectant composition according to any one of claims 1 to 6, wherein the cloud point of (B-2) is 65 to 95 ° C. (2 wt% aqueous solution). The cleaning and disinfecting agent composition according to any one of claims 1 to 7, wherein the weight ratio of (B-1) and (B-2) is 1: 0.1 to 1: 6. (A-1) One or more compounds selected from the group consisting of polyhexamethylene biguanide hydrochloride, polyhexamethylene guanidine phosphate, polyhexamethylene guanidine hydrochloride, polyaminopropyl biguanide hydrochloride, and (A-2). A (A) cationic surfactant consisting of one or more di-long-chain alkyl di-short-chain alkylammonium methyl sulfates, and (B-1) one or more polyoxys having an HLB value of 10.5-12.5. It contains (B) a nonionic surfactant consisting of an alkylene alkyl ether and (B-2) one or more polyoxyalkylene alkyl ethers having an HLB value of 13.0 to 15.0.
The weight ratio of (A) and (B) is 1: 0.5 to 1: 1.5, and the pH when a 1% by weight aqueous solution is prepared is 2.5 to 5 for washing and sterilization. A method for producing an agent composition, which is a method for producing an agent composition.
(A) A method comprising a step of dissolving (B) a nonionic surfactant heated to a temperature of 35 to 45 ° C. in a cationic surfactant.