JP7048282B2 - External composition for skin - Google Patents

Description

The present invention relates to an external composition for skin containing glycyrrhetinic acid, glycyrrhizic acid, derivatives thereof, and / or salts thereof, and ufenamate, which improves ingrown hair.

Non-steroidal anti-inflammatory agents have almost no concern about serious side effects as seen in steroidal anti-inflammatory agents, and there are few restrictions on the amount and duration of use, so rash, redness, dry dermatitis, and atopy. It is also widely used as an external preparation for the purpose of alleviating inflammatory skin diseases such as sexual dermatitis.

Among the non-steroidal anti-inflammatory agents, glycyrrhetinic acid, glycyrrhizinic acid, derivatives thereof, and salts thereof (hereinafter, also referred to as "glycyrrhetinic acids"), and ufenamate have anti-inflammatory activity. It is widely used as an external preparation for pharmaceuticals or non-pharmaceutical products.

In addition, diphenhydramine and its salts have a strong histamine action, and are widely used as an external preparation for antipruritic or antipruritic drugs or quasi-drugs.

Since glycyrrhetinic acids, ufenamate, and diphenhydramine are easily destabilized in the formulation, a formulation design with enhanced formulation stability is required for an external preparation containing at least one of these. Therefore, conventionally, a formulation technique for enhancing the formulation stability of an external preparation containing at least one of glycyrrhetinic acid, ufenamate, and diphenhydramine has been studied. For example, Patent Document 1 describes at least one of glycyrrhetinic acids, ufenamate, and diphenhydramine, one or more selected from a predetermined glycerin fatty acid ester and a polyglycerin fatty acid ester, a predetermined polyoxyethylene hydrogenated castor oil, and a silicone oil. It has been reported that a water-in-oil cream pharmaceutical preparation containing a liquid higher alcohol at 25 ° C. can secure viscosity stability at low temperature and high temperature storage and retain the cream dosage form.

On the other hand, the treatment for removing body hair has been conventionally performed. Hair removal, shaving, and hair removal are known as methods for removing body hair, and in recent years, they have been widely used regardless of age and gender, as well as self-treatment and treatment by specialized institutions (medical institutions and non-medical institutions). It is done. Since the hair removal treatment causes inflammation in the pores to a considerable extent, troubles are likely to occur due to the pores being closed after the treatment. For example, in the case of a treatment method that does not destroy the hair papilla, the hair that grows after the treatment grows in the skin without being able to penetrate the skin, and in the case of light irradiation hair removal, the hair after hair removal is not discharged from the pores. The phenomenon that the hair remains in the skin (the hair that stays in the skin in this way is called "ingrown hair") is likely to occur. If the treatment is performed by a medical institution, steroids are usually prescribed to suppress inflammation after light irradiation hair removal (laser hair removal). However, steroids have problems such as side effects and restrictions on the amount and duration of use. In the case of non-medical institutions or self-treatment, it is difficult to effectively prevent troubles caused by buried hair after treatment, and due to the recent pandemic of hair removal treatment, troubles caused by buried hair after treatment will be delayed. There is no end.

Japanese Unexamined Patent Publication No. 2017-7958

An object of the present invention is to provide an external skin preparation containing a novel ingredient as an active ingredient for improving ingrown hair generated after a treatment for removing body hair.

The present inventor has made diligent studies to solve the above problems, and found that glycyrrhetinic acid, glycyrrhizic acid, derivatives thereof, and / or salts thereof, ufenamate, diphenhydramine and / or salts thereof are used alone. Although no effect on ingrown hair was observed, it was found that the ingrown hair generated after the body hair removal treatment could be improved by blending them in combination. The present invention has been completed by further studies based on these findings.

That is, the present invention provides the inventions of the following aspects.
Item 1. Hair removal containing (A) at least one selected from the group consisting of glycyrrhetinic acid, glycyrrhizic acid, derivatives thereof, and salts thereof, (B) ufenamate, and (C) diphenhydramine and / or a salt thereof. External composition for skin after treatment.
Item 2. (D) The external composition for skin after the hair removal treatment according to Item 1, which contains tocopherol and / or a derivative thereof.
Item 3. Item 2. The external composition for skin after the hair removal treatment according to Item 1 or 2, which is an oil-in-water emulsified composition.
Item 4. Ingrown hair containing (A) glycyrrhetinic acid, glycyrrhizic acid, derivatives thereof, and at least one selected from the group consisting of salts thereof, (B) ufenamate, and (C) diphenhydramine and / or salts thereof. Improving agent.

The external composition for skin of the present invention can improve the ingrown hair generated after the hair removal treatment by containing glycyrrhetinic acid, ufenamate, diphenhydramine and / or a salt thereof.

1. 1. External composition for skin after hair removal treatment The external composition for skin after hair removal treatment of the present invention is at least one selected from the group consisting of glycyrrhetinic acid, glycyrrhizic acid, derivatives thereof, and salts thereof (1). Hereinafter, it may be referred to as (A) component), ufenamate (hereinafter, may be referred to as (B) component), diphenhydramine and / or a salt thereof (hereinafter, may be referred to as (C) component). It is characterized by containing (is). Hereinafter, the external composition for skin of the present invention will be described in detail.

(A) Glycyrrhizic Acids The external composition for skin of the present invention contains glycyrrhetinic acid, glycyrrhizic acid, derivatives thereof, and / or salts thereof.

Glycyrrhetinic acid is a known drug known to have an anti-inflammatory action, an antiallergic action and the like.

Glycyrrhizic acid is a known drug known to have anti-inflammatory action, antiallergic action and the like.

The derivative of glycyrrhetinic acid is not particularly limited as long as it is pharmaceutically acceptable, and specific examples thereof include pyridoxine glycyrrhetinate, stearyl glycyrrhetinate, glyceryl glycyrrhetinate, and monoglucuronide glycyrrhetinate. These derivatives of glycyrrhetinic acid may be used alone or in combination of two or more.

The derivative of glycyrrhizic acid is not particularly limited as long as it is pharmaceutically acceptable, and specific examples thereof include methyl glycyrrhizinate and stearyl glycyrrhizinate. These derivatives of glycyrrhizic acid may be used alone or in combination of two or more.

The salt of glycyrrhizinic acid, glycyrrhetinic acid and / or a derivative thereof is not particularly limited as long as it is pharmaceutically acceptable, but specifically, an alkali metal salt such as a sodium salt or a potassium salt; an ammonium salt or the like can be used. Can be mentioned. These salts may be used alone or in combination of two or more.

The external composition for skin of the present invention contains glycyrrhetinic acid, a salt of glycyrrhetinic acid, a derivative of glycyrrhetinic acid, a salt of a derivative of glycyrrhetinic acid, glycyrrhizinic acid, a salt of glycyrrhizic acid, a derivative of glycyrrhizic acid, and One of the salts of the derivative of glycyrrhizinic acid may be selected and used, or two or more thereof may be used in combination.

Among these components (A), glycyrrhetinic acid, glycyrrhizic acid, and salts thereof are preferable; more preferably glycyrrhetinic acid, salts of glycyrrhizic acid; particularly preferably. , Glycyrrhizic acid, dipotassium glycyrrhizinate.

In the external composition for skin of the present invention, the content of the component (A) is not particularly limited and may be appropriately set according to the medicinal effect to be imparted. For example, the total amount of the component (A) may be used. 0.01 to 10% by weight is mentioned, and from the viewpoint of more effectively improving the buried hair, 0.01 to 5% by weight is preferable, and more preferably 0.05 to 2% by weight.

(B) Ufena Mart The external composition for skin of the present invention contains Ufena Mart. Ufenamate, also called butyl flufenamic acid, is a known drug as a fat-soluble non-steroidal anti-inflammatory drug.

In the external composition for skin of the present invention, the content of the component (B) is appropriately set according to the medicinal effect to be exerted, and for example, 1 to 20% by weight is mentioned, and the buried hair is more effective. From the viewpoint of improvement, preferably 1 to 6% by weight, more preferably 1 to 5% by weight.

In the external composition for skin of the present invention, the ratio of the component (B) to the component (A) is determined according to the contents of the component (A) and the component (B). The total amount of the component (B) is 10 to 200,000 parts by weight per 100 parts by weight of the total amount, and from the viewpoint of more effectively improving the buried hair, it is preferably 20 to 60,000 parts by weight, more preferably 50 to 10,000 parts by weight. Can be mentioned.

(C) Diphenhydramine and / or a salt thereof The external composition for skin of the present invention contains diphenhydramine and / or a salt thereof. Diphenhydramine and / or a salt thereof can be used in combination with the components (A) and (B) to improve ingrown hair, and has a composition containing the components (A) and (B). It is also possible to improve the instability of the substance to form a precipitate or a precipitate, and to suppress the formation of a precipitate or a precipitate of the external composition for skin of the present invention.

Diphenhydramine is a known drug known to have antihistamine activity.

The salt of diphenhydramine is not particularly limited as long as it is pharmaceutically acceptable, but specifically, hydrochloride, citrate, succinate, tartrate, fumarate, maleate, salicylate. , Diphenyldisulfonate, tannate, lauryl sulfate, acid addition salts such as sulfate. These salts may be used alone or in combination of two or more.

The external composition for skin of the present invention may be used by selecting one from diphenhydramine and a salt thereof as the component (C), or may be used in combination of two or more.

Among these components (C), diphenhydramine and diphenhydramine hydrochloride are preferably mentioned from the viewpoint of more effectively improving the buried hair or effectively suppressing the formation of precipitates and precipitates.

In the external composition for skin of the present invention, the content of the component (C) is not particularly limited, and for example, the total amount of the component (C) may be 0.01 to 5% by weight. From the viewpoint of improving the buried hair more effectively or suppressing the formation of precipitates and precipitates more effectively, the content of the component (C) in the external composition for skin of the present invention is preferably 0. 1 to 3% by weight, more preferably 0.1 to 2% by weight.

In the external composition for skin of the present invention, the ratio of the component (C) to the component (A) is determined according to the contents of the component (A) and the component (C). The total amount of the component (C) is 0.1 to 50,000 parts by weight per 100 parts by weight of the total amount. From the viewpoint of improving the buried hair more effectively or suppressing the formation of precipitates and precipitates more effectively, the total amount of the component (C) is preferably per 100 parts by weight of the total amount of the component (A). 2 to 30,000 parts by weight, more preferably 5 to 4000 parts by weight.

(D) Tocopherol and / or its derivative The composition for external use for skin of the present invention, together with the above-mentioned component, is a tocopherol and / or a derivative thereof (hereinafter, "(D) component". It may be described as).

Tocopherol is a known compound known as Vitamin E. The tocopherol may be any of d-form, l-form, and dl-form, but dl-form is preferable. Further, the tocopherol may be any of α-form, β-form, γ-form, and δ-form, but α-form is preferable.

The derivative of tocopherol is not particularly limited as long as it is pharmaceutically acceptable, and examples thereof include an ester form with a carboxylic acid such as acetic acid, nicotinic acid, and succinic acid, and a diester form with phosphoric acid. Among these tocopherol derivatives, from the viewpoint of more effectively improving ingrown hair, an ester form with a carboxylic acid is preferable, and tocopherol acetate is more preferable.

The derivative of tocopherol may be d-form, l-form, or dl-form, but dl-form is preferable. Further, the derivative of tocopherol may be any of α-form, β-form, γ-form, and δ-form, but α-form is preferable.

In the external composition for skin of the present invention, as the component (D), one of tocopherol and its derivative may be selected and used alone, or two or more thereof may be used in combination. Among the components (D), from the viewpoint of more effectively improving buried hair, preferably a derivative of tocopherol, more preferably an ester of tocopherol with a carboxylic acid, still more preferably tocopherol acetate, particularly preferably d-α acetate. -Tocopherol, l-α-tocopherol acetate, dl-α-tocopherol acetate can be mentioned.

The content of the component (D) in the external composition for skin of the present invention is not particularly limited, but from the viewpoint of more effectively improving the ingrown hair, the total amount of the component (D) is, for example, 0.01 to 10. By weight%, preferably 0.01 to 5% by weight, more preferably 0.05 to 1% by weight.

Further, in the external composition for skin of the present invention, the ratio of the component (D) to the component (A) is determined based on the range of the content of each component, but from the viewpoint of more effectively improving the ingrown hair. Therefore, the total amount of the component (D) is 0.1 to 100,000 parts by weight, preferably 0.2 to 50,000 parts by weight, and more preferably 2.5 to 2,000 parts by weight per 100 parts by weight of the component (A).

Higher Alcohol Solid at 25 ° C. The external composition for skin of the present invention may contain a higher alcohol solid at 25 ° C. When the external composition for skin of the present invention is prepared as an emulsified composition from a component forming an oil phase and a component forming an aqueous phase by containing a solid higher alcohol at 25 ° C., the oil phase and the composition It is possible to suppress the phase separation of the aqueous phase and improve the stability of the formulation.

The higher alcohol solid at 25 ° C. is not particularly limited as long as it is pharmaceutically acceptable, and examples thereof include 12 to 34 carbon atoms. As higher alcohols that are solid at 25 ° C, specifically, lauryl alcohol, mysticyl alcohol, cetanol, stearyl alcohol, cetostearyl alcohol, oleyl alcohol, linolyl alcohol, behenyl alcohol, araxyl alcohol, behenyl alcohol, lignoceryl alcohol, ceryl. Examples thereof include alcohol, montanyl alcohol, myricyl alcohol, and gesil alcohol. These higher alcohols may be used alone or in combination of two or more.

Among these higher alcohols, higher alcohols having 16 to 22 carbon atoms are preferable, and lauryl alcohols and mistyryl alcohols are more preferable, from the viewpoint of further improving the effect of suppressing the phase separation between the oil phase and the aqueous phase. , Cetanol, stearyl alcohol, cetostearyl alcohol, behenyl alcohol; more preferably, cetanol, stearyl alcohol, stearyl alcohol, behenyl alcohol; particularly preferably cetanol, stearyl alcohol.

In the external composition for skin of the present invention, the content of the higher alcohol solid at 25 ° C. is not particularly limited, but for example, the total amount of the higher alcohol solid at 25 ° C. is 0.3 to 20% by weight or more. Can be mentioned. From the viewpoint of more effectively suppressing the phase separation between the oil phase and the aqueous phase, the content of the higher alcohol solid at 25 ° C. in the external composition for skin of the present invention is preferably 0.3 to 15% by weight. , More preferably 0.5 to 10% by weight.

In the external composition for skin of the present invention, the ratio of the higher alcohol solid at 25 ° C to the component (A) is determined according to the content of the component (A) and the higher alcohol solid at 25 ° C, for example. , (A) The total amount of the higher alcohol solid at 25 ° C. is 3 to 200,000 parts by weight per 100 parts by weight of the total amount of the component. From the viewpoint of more effectively suppressing the phase separation between the oil phase and the aqueous phase, the total amount of the higher alcohol solid at 25 ° C. is preferably 3 to 150,000 parts by weight per 100 parts by weight of the total amount of the component (A). More preferably, 25 to 20000 parts by weight is mentioned.

Lanolin Alcohol The external composition for skin of the present invention may contain lanolin alcohol. In particular, by containing lanolin alcohol together with the above-mentioned solid higher alcohol at 25 ° C., the external composition for skin of the present invention is prepared as an emulsified composition from a component forming an oil phase and a component forming an aqueous phase. In this case, the phase separation between the oil phase and the aqueous phase can be suppressed more effectively, and the stability of the formulation can be dramatically improved.

Lanolin alcohol is an alcohol component obtained by saponifying and decomposing sheep sebum (wool grease) or lanolin, and is also called wool wax alcohol.

Lanolin alcohol is rich in compounds having a steroid skeleton such as cholesterol, lanosterol, and dihydrolanosterol, and contains monohydric or divalent alcohols (normal alcohol, isoalol, and anteisoalcohol) having about 14 to 36 carbon atoms. It has been.

The content of lanolin alcohol in the external composition for skin of the present invention is not particularly limited, and examples thereof include 0.1 to 20% by weight of the total amount of lanolin alcohol. From the viewpoint of more effectively suppressing the phase separation between the oil phase and the aqueous phase, the content of lanolin alcohol in the external composition for skin of the present invention is preferably 0.1 to 15% by weight, more preferably 0. .3 to 10% by weight.

In the external composition for skin of the present invention, the ratio of lanolin alcohol to the component (A) is determined according to the contents of the component (A) and the lanolin alcohol. For example, the total amount of the component (A) is 100 parts by weight. The total amount of lanolin alcohol is 1 to 200,000 parts by weight. From the viewpoint of more effectively suppressing the phase separation between the oil phase and the aqueous phase, the total amount of lanolin alcohol is preferably 2-150,000 parts by weight, more preferably 15 to 1 part by weight per 100 parts by weight of the total amount of the component (A). 20000 parts by weight is mentioned.

Non-polar oil In the external composition for skin of the present invention, when a non-polar oil is prepared as an emulsified composition from a component forming an oil phase and a component forming an aqueous phase, a non-polar oil is used as a component forming the oil phase. It may be included. In the prior art, when a non-polar oil is contained in the composition containing the component (A) and the component (B), the formation of precipitates and precipitates tends to be remarkable, but in the external composition for skin of the present invention. Even if non-polar oil is contained, the formation of precipitates and precipitates can be effectively suppressed.

The non-polar oil means an oil having an IOB (inorganic / organic balance) of 0 or more and less than 0.05, and specific examples thereof include hydrocarbon oils extracted from mineral oil. Such hydrocarbon oil is not particularly limited as long as it is pharmaceutically acceptable, and for example, liquid paraffin (liquid normal paraffin, liquid isoparaffin), α-olefin oligomer, petrolatum, microcrystalline wax, gelation. Examples include hydrocarbons (plastibase, etc.), hydrogenated polyisobutene, and the like. These non-polar oils may be used alone or in combination of two or more.

Among these non-polar oils, liquid paraffin, α-olefin oligomer, petrolatum, microcrystalline wax are preferable, liquid paraffin and petrolatum are more preferable, and liquid paraffin is particularly preferable.

In the external composition for skin of the present invention, the content of the non-polar oil may be appropriately set in consideration of the emulsified form, the feeling of use, etc. of the external composition for skin, and for example, the external composition for skin of the present invention. When the product is prepared as an oil-in-water emulsifying composition, the total amount of the non-polar oil is 1% by weight or more, preferably 1 to 30% by weight. Further, in the prior art, when the non-polar oil is contained in an amount of 5% by weight or more, particularly 8% by weight or more in the external composition for skin containing the component (A) and the component (B), the precipitate or the precipitate is contained. Although the formation tends to be significantly promoted, the external composition for skin of the present invention can suppress the formation of precipitates and precipitates even if the non-polar oil is contained in such a high content. ing. In view of such effects of the present invention, the content of the non-polar oil in the external composition for skin of the present invention is more preferably 5 to 30% by weight, particularly preferably 8 to 30% by weight. When the external composition for skin of the present invention is prepared as a water-in-oil emulsified composition, the non-polar oil may be contained in a higher content. In this case, the content of the non-polar oil in the external composition for skin of the present invention may be, for example, 40 to 95% by weight, preferably 50 to 90% by weight.

Polar oil The external composition for skin of the present invention contains polar oil as a component forming an oil phase when prepared as an emulsified composition from a component forming an oil phase and a component forming an aqueous phase. You may. When the non-polar oil is contained in the external composition for skin of the present invention, the polar oil may not be contained, or the non-polar oil and the polar oil may be used in combination.

The polar oil means an oil having an IOB (inorganic / organic balance) in the range of 0.05 to 1.1. The polar oil is not particularly limited as long as it is pharmaceutically acceptable, and examples thereof include animal oils, mineral oils, fatty acid alkyl esters, and fatty acids.

Specific examples of vegetable oils include olive oil, wheat germ oil, rice oil, safflower oil, soybean oil, camellia oil, corn oil, rapeseed oil, sesame oil, sunflower oil, sunflower oil, cottonseed oil, peanut oil, jojoba oil, and hardened oil. , Avocado oil, uikyo oil, butterfly oil, peppermint oil, eucalyptus oil, lemon oil, orange oil, carnauba wax, candelilla wax, rice bran, wood wax and the like. These vegetable oils may be used alone or in combination of two or more.

Specific examples of the animal oil include lard, fish oil, beeswax and the like. These animal oils may be used alone or in combination of two or more.

Examples of the fatty acid alkyl ester include esters of fatty acids having 4 to 30 carbon atoms and alcohols having 1 to 34 carbon atoms. Specifically, glyceryl triisopalmitate, glyceryl tri2-ethylhexanate, glyceryl triisooctanoate, octyldodecyl myristate, diisostearyl malate, neopentylglycoldioctanoate, dipentaerythrit fatty acid ester, hydroxysteare. Cholesteryl acid isopropyl adipate, isobutyl adipate, diethyl sevacinate, isopropyl sevacinate, diisopropyl sevacinate, cetyl ethylhexanate, isopropyl myristate, myristyl myristate, isopropyl palmite, cetyl palmitate, ethyl oleate, bacil stearate , Hexyldecyl isostearate, isopropyllinoleate, glyceryl tri (caprylic capric acid), cetyl octanate, butyl stearate, hexyl laurate, decyl oleate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, lanolin acetate, Isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearyl acid, ethylene glycol di2-ethylhexanate, dipentaerythritol fatty acid ester, N-alkylglycol monoisostearate, neopentylglycol dicaprate, di2-heptylundecanoic acid Glycerin, Trimethylol Propane tri2-ethylhexanoate, Trimethylol Propane triisostearate, Pentaerislit Tetra2-ethylhexanoate, Trimethylolpropane triisostearate, Cetyl 2-ethylhexanoate, 2-Ethylhexyl palmitate, Diethylhexyl naphthalin dicarboxylate, alkyl benzoate (12 to 15 carbon atoms), cetearyl isononanoate, tri (caprylic acid / caprylic acid) glycerin, (dicaprylic acid / caprylic acid) butylene glycol, glycerin trimyristate, tri 2 -Heptylundecanoic acid glyceride, castor oil fatty acid methyl ester, oleate oleate, cetostearyl alcohol, acetoglyceride, palmitic acid 2-heptylundecyl, N-lauroyl-L-glutamic acid-2-octyldodecyl ester, di-2-adipate Heptylundecyl, ethyllaurate, di2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyldecyl adipate, di2-ethylhexyl succinate Le etc. can be mentioned. These fatty acid alkyl esters may be used alone or in combination of two or more.

Examples of the fatty acid include fatty acids having 4 to 30 carbon atoms, and specific examples thereof include lauric acid, myristic acid, palmitic acid, sebacic acid, oleic acid, and linoleic acid. These fatty acids may be used alone or in combination of two or more.

Among these polar oils, fatty acid alkyl esters are preferably mentioned.

These polar oils may be used alone or in combination of two or more.

In the external composition for skin of the present invention, the content of the polar oil may be appropriately set in consideration of the emulsified form, usability, etc. of the external composition for skin, and is, for example, 0.5 to 20% by weight. It is preferably 1 to 20% by weight, more preferably 3 to 15% by weight.

Polyoxyethylene hydrogenated castor oil The external composition for skin of the present invention may contain polyoxyethylene hydrogenated castor oil. By containing the polyoxyethylene hydrogenated castor oil, it becomes possible to further improve the effect of suppressing the formation of precipitates and precipitates.

The polyoxyethylene cured castor oil used in the present invention is not particularly limited, and for example, polyoxyethylene (5) cured castor oil, polyoxyethylene (10) cured castor oil, and polyoxyethylene (20) cured castor oil. Oil, polyoxyethylene (30) cured castor oil, polyoxyethylene (40) cured castor oil, polyoxyethylene (50) cured castor oil, polyoxyethylene (60) cured castor oil, polyoxyethylene (80) cured castor oil Examples thereof include oil, polyoxyethylene (100) hardened castor oil and the like. These polyoxyethylene hydrogenated castor oils may be used alone or in combination of two or more.

Among these polyoxyethylene cured castor oils, polyoxyethylene (20) cured castor oil and polyoxyethylene (30) cured castor oil are preferable from the viewpoint of more effectively suppressing the formation of precipitates and precipitates. Oil, polyoxyethylene (40) hardened castor oil, polyoxyethylene (50) hardened castor oil, polyoxyethylene (60) hardened castor oil, polyoxyethylene (80) hardened castor oil, polyoxyethylene (100) hardened castor oil Oil; more preferably, polyoxyethylene (50) hardened castor oil can be mentioned.

The content of the polyoxyethylene hydrogenated castor oil in the external composition for skin of the present invention is not particularly limited, and for example, the total amount of the polyoxyethylene hydrogenated castor oil may be 0.1 to 10% by weight. From the viewpoint of more effectively suppressing the formation of precipitates and precipitates, the content of polyoxyethylene cured castor oil in the external composition for skin of the present invention is preferably 0.1 to 8% by weight, more preferably. Is 0.2 to 5% by weight.

In the external composition for skin of the present invention, the ratio of the polyoxyethylene hydrogenated castor oil to the component (A) is determined according to the contents of the component (A) and the polyoxyethylene hydrogenated castor oil. A) The total amount of polyoxyethylene hydrogenated castor oil is 1 to 100,000 parts by weight per 100 parts by weight of the total amount of the components. From the viewpoint of more effectively suppressing the formation of precipitates and precipitates, the total amount of polyoxyethylene hydrogenated castor oil is preferably 2 to 80,000 parts by weight, more preferably 2 to 80,000 parts by weight, per 100 parts by weight of the total amount of the component (A). Examples include 10 to 10,000 parts by weight.

Surfactant (other than polyoxyethylene hydrogenated castor oil)
When the composition for external use for skin of the present invention is prepared as an emulsified composition from a component forming an oil phase and a component forming an aqueous phase, the polyoxyethylene curing is performed in order to stably form an emulsified state. A surfactant other than castor oil may be contained. The surfactant (other than polyoxyethylene cured castor oil) is not particularly limited as long as it is pharmaceutically acceptable, and a nonionic surfactant (other than polyoxyethylene cured castor oil) and anionic surfactant. , Cationic surfactant or amphoteric surfactant may be used.

Specific examples of the nonionic surfactant (other than polyoxyethylene hydrogenated castor oil) include polyoxyethylene (10 to 50 mol) phytosterol ether, polyoxyethylene (10 to 50 mol) dihydrocholesterol ether, and polyoxyethylene. (10-50 mol) 2-octyldodecyl ether, polyoxyethylene (10-50 mol) decyltetradecyl ether, polyoxyethylene (10-50 mol) oleyl ether, polyoxyethylene (2-50 mol) cetyl ether, Polyoxyethylene (5-50 mol) behenyl ether, polyoxyethylene (5-30 mol) polyoxypropylene (5-30 mol) 2-decyltetradecyl ether, polyoxyethylene (10-50 mol) polyoxypropylene ( 2 to 30 mol) Polyoxyethylene alkyl ether such as cetyl ether, their phosphates and phosphates (polyoxyethylene cetyl ether sodium phosphate, etc.), polyoxyethylene (20 to 60 mol) sorbitan monoolate, polyoxy Ethylene (10-60 mol) sorbitan monoisostearate, polyoxyethylene (10-80 mol) glyceryl monoisostearate, polyoxyethylene (10-30 mol) glyceryl monostearate, polyoxyethylene (20-100 mol) )-Polyoxypropylene-modified silicone, polyoxyethylene-alkyl-modified silicone, monolaurate polyethylene glycol, monopalmitate polyethylene glycol, monostearate polyethylene glycol, dilaurate polyethylene glycol, dipalmitate polyethylene glycol, distearate polyethylene glycol, diolein Examples thereof include polyethylene glycol acid acid, polyethylene glycol dilysinoleate, polyoxyethylene hydrogenated castor oil (5-100), polysorbate (20-85), glycerin fatty acid ester (glycerin monostearate, etc.). These nonionic surfactants (other than polyoxyethylene hydrogenated castor oil) may be used alone or in combination of two or more.

Specific examples of the anionic surfactant include sodium polyoxyethylene lauryl ether sulfate, sodium lauryl sulfate, sodium myristyl sulfate, sodium N-lauroyl sarcosinate, sodium N-myristolyl sarcosinate, and sodium dodecylbenzene sulfonate. Examples thereof include hydrogenated coconut fatty acid monoglyceride sodium monosulfate, sodium lauryl sulfoacetate, sodium α-olefin sulfonate, sodium N-palmitoylglutarmate, sodium N-methyl-N-acyltaurine and the like. These anionic surfactants may be used alone or in combination of two or more.

Specific examples of the cationic surfactant include lauryltrimethylammonium chloride, stearyltrimethylammonium chloride, benzethonium chloride, benzalkonium chloride, stearyldimethylbenzylammonium chloride and the like. These cationic surfactants may be used alone or in combination of two or more.

Specific examples of the amphoteric tenside include coconut oil fatty acid amide propyl betaine, lauryldimethylaminoacetic acid betaine, lauryldimethylamine oxide, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine, and N-lauryl. Examples thereof include diaminoethyl glycine, N-myristyl diaminoethyl glycine, N-alkyl-1-hydroxyethyl imidazoline betaine sodium and the like. These amphoteric surfactants may be used alone or in combination of two or more.

Among these surfactants, a nonionic surfactant (other than polyoxyethylene hydrogenated castor oil) is preferably mentioned from the viewpoint of stably maintaining an emulsified state.

These surfactants may be used alone or in combination of two or more.

In the external composition for skin of the present invention, the content of the surfactant (other than polyoxyethylene hydrogenated castor oil) may be appropriately set according to the type of the surfactant, the emulsified form, etc., for example, 0. 5 to 10% by weight, preferably 1 to 9% by weight, still more preferably 2 to 8% by weight.

Water The external composition for skin of the present invention can contain water as a base material for forming an aqueous phase.

In the external composition for skin of the present invention, the content of water may be appropriately set in consideration of the properties (for example, emulsified state), usability, etc. of the external composition for skin, and is, for example, 10 to 90% by weight. , Preferably 20 to 85% by weight, more preferably 30 to 85% by weight.

Polyhydric alcohol In addition to the above-mentioned components, the external composition for skin of the present invention may contain a polyhydric alcohol, if necessary, in order to provide moisturizing properties and the like.

The polyhydric alcohol is not particularly limited as long as it is pharmaceutically acceptable, and examples thereof include ethylene glycol, propylene glycol, isoprene glycol, diethylene glycol, and dipropylene glycol. These polyhydric alcohols may be used alone or in combination of two or more.

The content of the polyhydric alcohol in the external composition for skin of the present invention is not particularly limited, but is, for example, 0.5 to 30% by weight, preferably 0.5 to 25% by weight, and more preferably 1 to 20% by weight. %.

Thickener The external composition for skin of the present invention may contain a thickener, if necessary, in order to have a desired viscosity and the like, in addition to the above-mentioned components.

The thickener is not particularly limited as long as it is pharmaceutically acceptable, but for example, xanthan gum, guar gum, locust bean gum, carrageenan, dextran, methyl cellulose, ethyl cellulose, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl. Cellulose, hydroxypropylmethyl cellulose, sodium alginate, propylene glycol alginate, polyvinyl alcohol, polyvinylpyrrolidone, polyvinylmethyl ether, carboxyvinyl polymer, alkyl acrylate copolymer, sodium bentonite polyacrylate, dextrin fatty acid ester, pectin, etc. Can be mentioned. Among these thickeners, xanthan gum and carboxyvinyl polymers are preferable. These thickeners can be used alone or in combination of two or more.

In the external composition for skin of the present invention, the content of the thickener may be appropriately set according to the viscosity to be imparted, for example, 0.01 to 5% by weight, preferably 0.1 to 4%. By weight%, more preferably 0.1 to 3% by weight.

Other Ingredients In addition to the above-mentioned ingredients, the external composition for skin of the present invention may contain other additives usually used for external skin preparations and the like, if necessary. Such additives include, for example, pH adjusters (eg, inorganic bases such as sodium hydroxide and potassium hydroxide, and basic substances such as organic amines such as triethanolamine and diisopropanolamine; Organic acids such as acids, tartaric acid, and lactic acid, as well as acidic substances such as inorganic acids such as phosphoric acid, sulfuric acid, nitrate, and hydrochloric acid), buffers, solubilizers, chelating agents (eg, edetic acid and edetate, etc.) ), Preservatives (eg, paraoxybenzoic acid esters such as methylparaben, ethylparaben, propylparaben, butylparaben; benzoic acid and benzoate; and sorbic acid and sorbate, etc.), preservatives, antioxidants, stabilizing Examples include agents, fragrances, coloring agents and the like.

Further, the external composition for skin of the present invention may contain a medicinal ingredient other than the above-mentioned ingredients, if necessary. Examples of such agents include steroids (dexamethasone, dexamethasone hydrochloride, dexamethasone acetate, hydrocortisone hydrochloride, prednisolone valerate, prednisolone acetate, etc.), antihistamines (chlorpheniramine maleate, etc.), and local anesthetics (lydkine, dibukine, etc.). Prokine, tetrakine, bupipacain, mepipacine, chloroprocine, proparakine, meprilkine or salts thereof, benzoic acid alkyl esters (eg ethyl aminobenzoate, diethylaminoethyl parabutylaminobenzoate), orthokine, oxesazein, oxypolyentoxydecane, Rohto extract, percuminpase, tesitdecitin, etc.), anti-inflammatory agents (alantin, salicylic acid, glycol salicylate, methyl salicylate, indomethacin, fervinac, diclofenac sodium, sodium loxoprofen, etc.), bactericides (benzalconium chloride, decalinium chloride, benzethonium chloride, chloride, etc.) Cetylpyridinium, isopropylmethylphenol, chlorhexidine hydrochloride, chlorhexidine gluconate, aqueous ammonia, sulfaziazine, lactic acid, phenol, etc.), antipruritic agent (crotamiton, thiantoll, etc.), skin protectant (corodion, castor oil, etc.), blood circulation promoting component (nonyl) Examples thereof include acid vanillylamide, nicotinic acid benzyl ester, capsaicin, capsicum extract, etc.), vitamins (vitamins A, B, C, D, etc.), mucopolysaccharides (sodium chondroitin sulfate, hyaluronic acid, etc.) and the like.

Properties, formulation form, etc. The properties of the external composition for skin of the present invention are not particularly limited, and examples thereof include an aqueous liquid composition, an aqueous gel composition, an oil gel composition, and an emulsified composition. Among these, from the viewpoint of formulation stability, an aqueous gel-like composition, an oil-based gel-like composition, and an emulsified composition are preferable, and an emulsified composition is more preferable. The emulsified state of the emulsified composition may be either an oil-in-water type or a water-in-oil type, but an oil-in-water type is preferable from the viewpoint of usability such as suppression of stickiness.

The formulation form of the external composition for skin of the present invention is not particularly limited, and examples thereof include lotions, emulsions, ointments, and creams. Among these, from the viewpoint of formulation stability, emulsions and creams are preferable.

Specific examples of the external composition for skin of the present invention include external pharmaceuticals, cosmetics and the like. Among these pharmaceutical forms, a pharmaceutical product for external use is preferably mentioned.

Method of Use The external composition for skin of the present invention is used by applying it to the skin after the hair removal treatment in order to improve the ingrown hair. The method of hair removal treatment includes hair removal (treatment by pulling out hair, including treatment of physically pulling out hair, and treatment of damaging or destroying the hair papilla by light irradiation), shaving (shaving of hair). (Treatment by melting hair) and hair removal (treatment by melting body hair).

The part of the skin to which the external composition for skin of the present invention is applied is not particularly limited as long as it is the part where the hair has been removed, and the upper limbs, lower limbs, axillae, chest, abdomen, back, and lumbar region. , Lower abdomen, facial part and the like.

Ingrown hair is improved at the skin site to which the external composition for skin of the present invention is applied. For example, after the hair removal treatment that does not destroy the dermal papilla, it is possible to prevent the pores from being closed after the treatment and to allow the hair that has grown after the treatment to grow outward from the pores. In the case of light irradiation hair removal, it is possible to prevent the pores from being closed after the treatment and to make it easier for the body hair after the hair removal to be discharged from the pores.

Production Method The external composition for skin of the present invention can be produced according to a known method for producing a composition. Examples of the production method when the external composition for skin of the present invention is an emulsified composition include the methods shown below. First, a composition for an oil phase is prepared by mixing (A) component, (B) component, (C) component, non-polar oil and / or polar oil, and other lipophilic components added as necessary. do. Separately, water and other water-soluble components added as needed are mixed to prepare an aqueous phase composition. When polyoxyethylene cured castor oil and / or a surfactant (other than polyoxyethylene cured castor oil) is contained, these may be either one or both of the oil phase composition and the aqueous phase composition. It may be added to the oil phase composition and mixed, but it is preferably added to the oil phase composition. Next, the obtained composition for an oil phase and the composition for an aqueous phase are mixed and emulsified by an emulsification method such as a homogenizer to produce the external composition for skin of the present invention.

2. 2. Ingrown Hair Improver The present invention also provides an ingrown hair improver. The ingrown hair improving agent of the present invention comprises at least one selected from the group consisting of (A) glycyrrhetinic acid, glycyrrhizic acid, derivatives thereof, and salts thereof, (B) ufenamate, (C) diphenhydramine and /. Or it is characterized by containing a salt thereof. Regarding the types and contents of (A) to (C) used in the ingrown hair improving agent, the types and contents of other components to be blended, the properties / pharmaceutical forms, etc., the usage method, the manufacturing method, etc. 1. The same applies to the case of "external composition for skin after hair removal treatment".

Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited thereto.

Test Example An emulsified external composition for skin having the composition shown in Table 1 was produced, and the effect of improving ingrown hair was evaluated. The method for producing an emulsified external composition for skin and the test method are as follows.

[Method for producing an emulsified external composition for skin]
First, among the components shown in the oil phase raw materials in Table 1, components other than the component (A) (glycyrrhetinic acid or dipotassium glycyrrhizinate) were weighed in a predetermined amount, heated to 80 ° C., and mixed. Then, the component (A) was added in a predetermined amount and mixed to prepare a composition for an oil phase. Separately, the components shown in the aqueous phase raw materials in Table 1 were weighed in a predetermined amount and mixed to prepare an aqueous phase composition. After heating the composition for the aqueous phase to 80 ° C., the composition for the oil phase at 80 ° C. was added little by little, and emulsification was performed while mixing. Then, the mixture was cooled to 30 ° C. to obtain an emulsified external composition for skin (cream preparation).

[Test method]
(Degree of improvement of ingrown hair)
Three subjects were repeatedly shaved with a razor (both anterior shin and both knees) at least once a week, and the external composition for each skin was applied to the shaved part once a day. I got it. After 4 weeks, the shaved part was observed, and the degree of improvement of the ingrown hair was evaluated according to the following criteria. Table 2 shows an example in which ingrown hair was observed (Comparative Example 1) and an example in which ingrown hair was not observed (Example 1). Ingrown hair is indicated by an arrow in Table 2.
<Criteria for the degree of improvement of ingrown hair>
◯: No ingrown hair was found in all three.
Δ: No ingrown hair was found in 1 or 2 people.
X: Ingrown hair is observed in all 3 persons.

(Usage evaluation)
Six subjects were asked to shave with a razor (both anterior shins) and to apply each skin external composition to the shaving area. The usability of the external composition for skin was evaluated according to the following criteria.
<Criteria for usability>
〇: 5 to 6 people feel that there is no stickiness and feel good to use △: 3 to 4 people feel that there is no stickiness and feel good to use ×: Feel that there is no stickiness and feel good to use 0 to 2 people

[Test results]
The results obtained are shown in Table 1. The external composition for skin (Comparative Examples 1 to 5) containing glycyrrhetinic acid, ufenamate, and diphenhydramine alone did not have an effect of improving ingrown hair.

On the other hand, the external composition for skin (Examples 1 to 3) containing glycyrrhetinic acid, ufenamate, and diphenhydramine was found to have an effect of improving ingrown hair. It was confirmed that the external composition for skin prepared in the same manner as in Example 1 except that it did not contain tocopherol acetate also had a better effect of improving ingrown hair than all the comparative examples. The degree of improvement effect was further better in Example 1.

Further, the external composition for skin of Examples 1 and 2 was an oil-in-water emulsified composition, and a better feeling of use was obtained as compared with the water-in-oil emulsified composition of Example 3.

When the appearance of the oily phase composition prepared in the manufacturing process of each external skin composition was visually observed immediately after the preparation, the liquid of the external composition for skin of Examples 1 to 3 was clear. , Precipitation was suppressed. Further, when each external composition for skin was stored at room temperature for 1 day and then the formation of precipitates was observed with a polarizing microscope, the external compositions for skin of Examples 1 to 3 showed that the precipitates were suppressed. .. Further, after storing each external composition for skin at 40 ° C. for 3 months and at 50 ° C. for 1 month, the appearance was observed. As a result, the external composition for skin of Examples 1 to 3 was oil under any storage condition. The phase separation between the phase and the aqueous phase could be suppressed. As described above, the external composition for skin of Examples 1 to 3 was also excellent in pharmaceutical stability.

Claims (3)

(A) At least one selected from the group consisting of glycyrrhetinic acid, glycyrrhizinic acid, pyridoxin glycyrrhetinate, stearyl glycyrrhetinate, glyceryl glycyrrhetinate, monoglucuronide glycyrrhetinate, methyl glycyrrhizinate, stearyl glycyrrhizinate , and salts thereof. An ingrown hair improving agent after a body hair removal treatment, which contains (B) ufenamate and (C) diphenhydramine and / or a salt thereof. (D) Claim 1 contains tocopherol, an ester of tocopherol and acetic acid, an ester of tocopherol and nicotinic acid, an ester of tocopherol and succinic acid, and / or a diester of tocopherol and phosphoric acid . The buried hair improving agent after the body hair removal treatment described. The ingrown hair improving agent after the body hair removing treatment according to claim 1 or 2, which is an oil-in-water emulsified composition.