JP7101068B2 - Hair restorer - Google Patents

Description

The present invention relates to a hair restorer.

Since minoxidil has an excellent hair growth effect, a technique for blending it with a hair restorer or the like has been studied (Patent Documents 1 and 2).
Patent Document 1 (Japanese Unexamined Patent Publication No. 2007-45712) describes a scalp hair cosmetic containing a polyhydric alcohol, an organic acid, menthol and a specific component, and minoxidil can be used as the specific component. Is described. Further, it is described in the same document that such a scalp hair cosmetic has an excellent refreshing sensation when applied externally, and in particular, has an excellent sustainability of the refreshing sensation, a good usability, and a high hair growth effect. There is.

Further, Patent Document 2 (Japanese Unexamined Patent Publication No. 2006-143640) describes flavanonols, eucalyptus extract and menthol with respect to hair growth and hair growth agents having excellent hair growth and hair growth effects and exhibiting a good usability. The hair-growth / hair-growth agent to be contained is described, and it is described that minoxidil can be further added to the hair-growth / hair-growth agent.

Japanese Unexamined Patent Publication No. 2007-45712 Japanese Unexamined Patent Publication No. 2006-143640

Here, minoxidil is a component that is sparingly soluble in water. Then, when the present inventors examined a hair restorer containing minoxidil, it became clear that there is room for improvement in storage stability at low temperatures.

Therefore, the present invention provides a hair-growth agent having an excellent hair-growth effect and storage stability at low temperatures.

The present invention
A hair restorer that contains undiluted solution and carbon dioxide.
The undiluted solution contains the following components (A) to (C):
(A) Minoxidil of 0.7% (mass / volume) or more and 10% (mass / volume) or less with respect to the undiluted solution.
(B) Contains 40% (mass / volume) or more of ethanol and (C) water with respect to the undiluted solution.
The present invention provides a hair restorer containing 0.5% (mass / volume) or more and 5% (mass / volume) or less of the carbon dioxide with respect to the undiluted solution.

According to the present invention, it is possible to provide a hair-growth agent having an excellent hair-growth effect and storage stability at a low temperature.

Hereinafter, embodiments of the present invention will be described with reference to specific examples of each component. In addition, each component can be used alone or in combination of two or more.
The hair restorer in the present embodiment contains a stock solution containing component (A): minoxidil, component (B): ethanol and component (C): water, and carbon dioxide. The components (A) and (B) and the carbon dioxide content (g) in 100 mL of the undiluted solution are each in a specific range.
Here, in the present specification, the ratio of the mass (g) of the component to 100 mL of the undiluted solution at 20 ° C. is "(mass (g) of the component) / (100 mL of undiluted solution) x 100 (%)", that is, "(mass / volume). )% ”Is also simply described as“% ”.

(Undiluted solution)
(Ingredient (A))
The component (A) is minoxidil.
The content of the component (A) in the hair restorer is 0.7% or more, preferably 0.8% or more, more preferably 0.9, with respect to the undiluted solution from the viewpoint of improving the feeling of hair growth effect. % Or more, more preferably 2% or more, even more preferably 3% or more, particularly preferably 4% or more, particularly preferably 4.5% or more, and particularly preferably 4.8% or more.
Further, from the viewpoint of suppressing the sticky feeling, the content of the component (A) in the hair restorer is 10% or less, preferably 8% or less, more preferably 6% or less, still more preferably 4 with respect to the undiluted solution. % Or less, even more preferably 3% or less, particularly preferably 2% or less, particularly preferably 1.8% or less, particularly preferably 1.5% or less, particularly preferably 1.3% or less, particularly preferably 1. It is 2% or less.

(Component (B))
The component (B) is ethanol.
The content of the component (B) in the hair restorer is 40% or more, preferably 50% or more, more preferably 53% or more with respect to the undiluted solution from the viewpoint of improving the solubility of the component (A). , More preferably 55% or more.
Further, the content of the component (B) in the hair restorer is less than 99.3%, preferably 90% or less, more preferably 80% or less with respect to the undiluted solution from the viewpoint of preferably adjusting the dryness of the agent. , More preferably 70% or less, even more preferably 68% or less, and even more preferably 64% or less.

(Component (C))
The component (C) is water. As the water, ion-exchanged water, distilled water, or the like can be used.
When the hair restorer contains water, the water content is, for example, the remaining amount of the components (A) and (B) and other components in the stock solution.
Further, the content of the component (C) in the hair restorer is preferably 5% or more, more preferably 10% or more, still more preferably 15% with respect to the undiluted solution from the viewpoint of preferably adjusting the dryness of the agent. Above, even more preferably 20% or more.
Further, from the viewpoint of enhancing the solubility of the component (A), the content of the component (C) in the hair restorer is 59.3% or less, preferably 45% or less, more preferably 40% with respect to the undiluted solution. Below, it is more preferably 35% or less.

(carbon dioxide)
Since the hair-growth agent of the present embodiment contains a specific amount of carbon dioxide together with the above-mentioned undiluted solution, the precipitation of the component (A) at low temperature is suppressed, the low-temperature storage stability is excellent, and the user realizes an excellent hair-growth effect. Can be made to. Specifically, carbon dioxide is added to the hair restorer as a propellant.
The content of carbon dioxide in the hair restorer is 0.5% or more, preferably 0.8% or more, more preferably 1.2% or more with respect to the undiluted solution from the viewpoint of improving the low temperature storage stability of the hair restorer. % Or more, more preferably 1.5% or more, still more preferably 1.8% or more.
Further, from the viewpoint of improving economic efficiency and solubility, the content of carbon dioxide in the hair restorer is 5% or less, preferably 4% or less, still more preferably 3% or less, still more preferably 3% or less, based on the undiluted solution. Is less than 2.5%.

The mass ratio of the carbon dioxide content to the content of the component (A) in the hair restorer ((carbon dioxide) / (A)) has a viewpoint of improving the low temperature storage stability of the hair restorer and a feeling of hair growth effect. From the viewpoint of improvement, it is preferably 0.2 or more, and more preferably 0.3 or more.
Further, from the viewpoint of improving solubility, the mass ratio ((carbon dioxide) / (A)) is preferably 10 or less, more preferably 5 or less, and further preferably 2.5 or less.

In the present embodiment, the hair growth agent contains the components (A) to (C) and carbon dioxide, and the contents of the components (A), (B) and carbon dioxide with respect to the undiluted solution are in a specific range. Therefore, in the present embodiment, it is possible to obtain an excellent hair-growth effect and a hair-growth agent having excellent low-temperature storage stability.
Further, according to the present embodiment, for example, the feeling of bunch of hair when the hair growth agent is applied is suppressed, and the scalp (skin) can be made difficult to see by appropriately loosening the hair, and the hair growth agent with less stickiness can be obtained. It is also possible to obtain.

In the hair-growth agent of the present embodiment, the hair-growth agent may contain components other than the components (A) to (C) and carbon dioxide. For example, the hair restorer may preferably contain one or more components selected from the group consisting of the following components (D) to (H) in the undiluted solution.

(Component (D))
The component (D) is a polyhydric alcohol having a molecular weight of 60 or more and 300 or less.
The molecular weight of the component (D) is 60 or more, preferably 70 or more, more preferably 80 or more, from the viewpoint of suppressing the precipitation of the component (A) and improving the storage stability of the hair restorer at a low temperature.
From the same viewpoint, the molecular weight of the component (D) is 300 or less, preferably 250 or less, still more preferably 150 or less, and even more preferably 100 or less.

Specific examples of the component (D) include 1,3-butylene glycol (molecular weight 90.12), propylene glycol (molecular weight 76.09), dipropylene glycol (molecular weight 134.17), polypropylene glycol, and glycerin (molecular weight 106.12). ), Ethylene glycol (molecular weight 62.07), diethylene glycol (molecular weight 90.12), triethylene glycol (molecular weight 150.17) and polyethylene glycol.
Here, the molecular weights of polypropylene glycol and polyethylene glycol, which are the components (D), are the methods described in the "17th Amendment of the Japanese Pharmacy Law", each article of pharmaceutical products, and the average molecular weight test of macrogol 400 in the case of polyethylene glycol. In the case of polypropylene glycol, the number average molecular weight measured by the method described in "Pharmaceutical Additive Standard 2003", the average molecular weight test of polypropylene glycol 2000 in each article of pharmaceutical additives.
From the viewpoint of improving the solubility of the component (A) and making the scalp difficult to see, the component (D) is preferably selected from the group consisting of 1,3-butylene glycol, propylene glycol, dipropylene glycol and glycerin. It is one or more, preferably one or more selected from the group consisting of 1,3-butylene glycol, dipropylene glycol and glycerin, and more preferably 1,3-butylene glycol.

The content of the component (D) in the hair restorer is preferably 0.5% or more with respect to the undiluted solution from the viewpoint of improving the solubility of the component (A) and improving the transdermal absorbability, which is more preferable. Is 5% or more, more preferably 7% or more, still more preferably 8% or more, and particularly preferably 9% or more.
Further, from the viewpoint of reducing the stickiness of the scalp and hair and making the scalp difficult to see, the content of the component (D) in the hair restorer is preferably 20% or less, more preferably 15% with respect to the undiluted solution. Below, it is more preferably 12% or less.

Further, the mass ratio ((D) / (A)) of the content of the component (D) to the content of the component (A) in the hair restorer is determined from the viewpoint of improving transdermal absorbability and the low temperature storage of the hair restorer. From the viewpoint of improving stability, it is preferably 1 or more, and more preferably 3 or more.
Further, from the viewpoint of reducing the stickiness of the scalp and hair and making the scalp difficult to see, the mass ratio ((D) / (A)) is preferably 10 or less, more preferably 8 or less, still more preferably. It is 5 or less.

(Ingredient (E))
The component (E) is polyethylene glycol having an average molecular weight of 8,000 or more and 50,000 or less. Here, the average molecular weight of the component (E) is a number average molecular weight measured by the method described in the "17th revised Japanese Pharmacopoeia", the average molecular weight test of Macrogol 20000 in each article of pharmaceutical products.

The average molecular weight of the component (E) is 8000 or more, preferably 15000, from the viewpoint of reducing the sticky feeling of the hair and the scalp, making it easy to loosen the hair that tends to be bundled at the time of application, and making the scalp difficult to see. That is all. From the same viewpoint, the average molecular weight of the component (E) is 50,000 or less, preferably 40,000 or less, more preferably 30,000 or less, and further preferably 25,000 or less.

The content of the component (E) in the hair restorer is preferably 0.05% or more, more preferably 0.1% or more, still more preferably 0.2, with respect to the undiluted solution from the viewpoint of making the scalp difficult to see. % Or more.
Further, from the viewpoint of suppressing stickiness, the content of the component (E) in the hair restorer is preferably 2% or less, more preferably 1% or less, still more preferably 0.7% or less, and further preferably 0.7% or less with respect to the undiluted solution. More preferably, it is 0.5% or less.

Further, the mass ratio of the content of the component (E) to the content of the component (A) in the hair restorer ((E) / (A)) makes the scalp difficult to see and reduces the stickiness of the hair and the scalp. From the viewpoint, it is preferably 0.01 or more, and more preferably 0.06 or more.
Further, from the viewpoint of suppressing stickiness, the mass ratio ((E) / (A)) is preferably 1 or less, more preferably 0.5 or less, still more preferably 0.3 or less.

(Component (F))
The component (F) is an alkyl glyceryl ether having 16 or more carbon atoms and 22 or less carbon atoms.
The number of carbon atoms of the alkyl glyceryl ether having 16 to 22 carbon atoms is preferably 16 or more and 18 or less. The alkyl group may be linear or branched, but branching is preferred.
The alkyl glyceryl ether having 16 or more carbon atoms and 22 or less carbon atoms is preferably an isostearyl glyceryl ether.
From the viewpoint of transdermal absorbability, the content of the component (F) in the hair restorer is preferably 0.1% or more, more preferably 0.15% or more, still more preferably 0.18 with respect to the undiluted solution. % Or more.
From the same viewpoint, the content of the component (F) in the hair restorer is preferably 1% or less, more preferably 0.8% or less, still more preferably 0.5% or less, based on the undiluted solution. Even more preferably, it is 0.3% or less.

Further, the mass ratio ((F) / (A)) of the content of the component (F) to the content of the component (A) in the hair restorer is preferably 0.02 or more from the viewpoint of transdermal absorbability. Yes, more preferably 0.04 or more.
From the same viewpoint, the mass ratio ((F) / (A)) is preferably 0.3 or less, more preferably 0.2 or less, and further preferably 0.1 or more.

(Ingredient (G))
The component (G) is an organic acid or an inorganic acid having 2 or more and 6 or less carbon atoms.
Specific examples of the component (G) include organic acids having 2 or more and 6 or less carbon atoms such as lactic acid, glycolic acid, tartrate acid and citric acid; and inorganic acids such as phosphoric acid and hydrochloric acid.
From the viewpoint of further improving the low temperature storage stability of the hair restorer, the component (G) preferably contains one or more selected from the group consisting of lactic acid, citric acid and phosphoric acid, and more preferably lactic acid. include.

The content of the component (G) in the hair restorer is preferably 0.01% or more, more preferably 0.05% or more, based on the undiluted solution, from the viewpoint of further improving the low temperature storage stability of the hair restorer. More preferably, it is 0.1% or more.
Further, from the viewpoint of preventing coloring of the hair restorer, the content of the component (G) in the hair restorer is preferably 1% or less, more preferably 0.5% or less, still more preferably 0, with respect to the undiluted solution. It is 0.3% or less.

Further, the mass ratio ((G) / (A)) of the content of the component (G) to the content of the component (A) in the hair restorer is preferable from the viewpoint of further improving the low temperature storage stability of the hair restorer. Is 0.01 or more, more preferably 0.02 or more.
Further, from the viewpoint of preventing coloring of the hair restorer, the mass ratio ((G) / (A)) is preferably 0.6 or less, more preferably 0.5 or less, still more preferably 0.4 or less. Is.

(Component (H))
The component (H) is one or more selected from the group consisting of tocopherols and tocopherol esters. Specific examples of the tocopherol ester include tocopherol nicotinic acid ester, tocopherol acetate, and tocopherol succinic acid ester.
From the viewpoint of further enhancing the feeling of hair growth effect, the component (H) is preferably tocopherol acetate.

The content of the component (H) in the hair restorer is preferably 0.01% or more, more preferably 0.03% or more, and further preferably 0.03% or more with respect to the undiluted solution from the viewpoint of further improving the hair growth effect of the hair restorer. It is preferably 0.05% or more.
From the same viewpoint, the content of the component (H) in the hair restorer is preferably 0.5% or less, more preferably 0.3% or less, still more preferably 0.1% with respect to the undiluted solution. It is as follows.

Further, the mass ratio ((H) / (A)) of the content of the component (H) to the content of the component (A) in the hair restorer is preferable from the viewpoint of further improving the hair growth effect of the hair restorer. It is 0.01 or more, more preferably 0.02 or more.
Further, from the viewpoint of improving solubility, the mass ratio ((H) / (A)) is preferably 0.1 or less, more preferably 0.08 or less.

In addition to the above-mentioned components, the undiluted solution of the hair-growth agent can appropriately contain components used in a normal hair-growth agent according to a desired effect.
As such an optional component, for example, a surfactant other than the component (F);
Pyridoxine, pyridoxamine, pyridoxal, these hydrochlorides, vitamin B6 and its derivatives such as these 5'-phosphates, royal jelly extract, plant extracts with testosterone 5α-reductase inhibitory activity (eg, chowdi extract, aloe extract) , Birch extract) and other skin oil secretion inhibitors;
Antioxidants other than the component (H) such as dibutylhydroxytoluene, butylhydroxyanisole, and nordihydroguayaletic acid;
Cooling agents such as l-menthol, camphor, borneol, geraniol, linalool, cineole;
Penetration promoter;
Stabilizers can be mentioned. Each of these agents can be used without being limited to the intended use as each agent.

(PH)
The pH of the hair-growth agent of the present embodiment is preferably 5.0 or more, more preferably 5.5 or more, still more preferably 6 from the viewpoint of enhancing the stability of the component (A) in the hair-growth agent. It is 9.0 or more, preferably 9.0 or less, more preferably 8.5 or less, still more preferably 8.0 or less.
In the present specification, the pH of the hair restorer refers to a value obtained by directly measuring the hair restorer at 25 ° C. (glass electrode measurement method), and a specific measurement method will be described later in the section of Examples.

Next, a method for producing a hair restorer according to this embodiment will be described.
The method for producing a hair-growth agent of the present embodiment includes, for example, a step of preparing a stock solution containing the components (A) to (C) and a step of blending carbon dioxide into the stock solution to obtain a hair-growth agent.
Further, in the present embodiment, the method for improving the low temperature storage stability of the hair growth agent containing the component (A) is, for example, a step of preparing a stock solution containing the components (A) to (C) and carbon dioxide in the stock solution. Includes a step of blending to obtain a hair restorer.

In the step of preparing the undiluted solution, for example, the component (A) and other components are sequentially added to a container containing a predetermined amount of ethanol of the component (B) with stirring, and finally the water of the component (C) is added to 100 mL. Including the process.
Further, the step of blending carbon dioxide includes, for example, a step of putting the undiluted solution obtained in the above-mentioned step into a pressure-resistant container and filling it with carbon dioxide gas.
As another method, in the step of blending carbon dioxide, a component that generates carbon dioxide gas containing a carbonate such as sodium hydrogen carbonate is put in a pressure-resistant container, and an appropriate pH adjuster is added to the carbon dioxide gas. It may include a step of generating and immediately sealing, or a step of putting dry ice pellets in a container and sealing.

From the above, the hair restorer in this embodiment can be obtained. The hair restorer obtained in the present embodiment contains a stock solution containing components (A) to (C) and carbon dioxide, and the contents of the components (A), (B) and carbon dioxide with respect to the stock solution are in a specific range, respectively. Therefore, an excellent hair-growth effect can be obtained, and low-temperature storage stability is excellent. Further, the hair growth agent obtained in the present embodiment suppresses the feeling of bunch of hair when the hair growth agent is applied, and the hair can be appropriately loosened to make the scalp (skin) difficult to see, resulting in a sticky feeling. There are few.
Further, according to the present embodiment, the precipitation of the component (A) in the hair restorer is suppressed at a low temperature of, for example, 15 ° C. or lower, preferably 5 ° C. or lower, more preferably −5 ° C. or lower, and the storage stability is excellent. You can also get a hair restorer.

The hair-growth agent obtained in the present embodiment is, for example, an aerosol-type hair-growth agent. Moreover, the hair growth agent obtained in this embodiment may be a skin external use agent.
In the present embodiment, the method of using the hair-growth agent includes, for example, applying the hair-growth agent to the scalp, preferably applying the hair-growth agent to the scalp and blending it into the whole.

Although the embodiments of the present invention have been described above, these are examples of the present invention, and various configurations other than the above can be adopted.

(Examples 1 to 15 and Comparative Examples 1 to 4)
Hair growth agents having the compositions shown in Tables 1 and 2 were prepared and evaluated according to the following methods and criteria. The evaluation results are also shown in Tables 1 and 2.

(Preparation method of hair restorer)
The components listed in Table 1 were stirred and uniformly mixed to prepare a stock solution of the hair growth agent of each example. At 20 ° C., except for Comparative Example 1, 60 mL of the obtained undiluted solution was placed in 100 mL of a glass test bottle for aerosol (manufactured by Tokyo Polymer Co., Ltd.), which is a pressure resistant container, sealed with a bottle valve with packing, and then contained carbon dioxide. Carbon dioxide gas was sealed so that the amount was as shown in Table 1, and the hair restorer of each example was obtained. For Comparative Example 1, the obtained undiluted solution was placed in a liquid agent container to obtain a hair growth agent.
The pH of the hair restorer obtained in each example was measured by the following method.
(PH measurement method)
The pH of the undiluted solution was measured at 25 ° C. by a glass electrode measurement method using a pH meter manufactured by Horiba, Ltd. (pH meter: desktop pH / water quality analyzer F74, electrode: long ToupH electrode 9680S-10D).
The pH of each example of the hair-growth agent filled with carbon dioxide gas was measured at 25 ° C. by injecting 10 mL into a container and measuring after 2 minutes. The measuring device is the same as when measuring the pH of the undiluted solution.

The hair-growth agents obtained in each example were evaluated for percutaneous absorption, hair-growth effect, low-temperature storage stability, non-stickiness, and scalp resistance according to the following methods and criteria.
Here, regarding the transdermal absorbability and the hair growth effect, the transdermal absorbability was evaluated in each example shown in Table 1, and the hair growth effect was evaluated in each example shown in Table 2. For Example 12, the transdermal absorbability and hair growth effect were evaluated, and the evaluation results are shown in Tables 1 and 2.

(Evaluation method)
(1) Percutaneous absorption Diffusion cell array system Each well (hole) of the donor cell of INT420 (for skin permeation test, manufactured by Introtech) is filled with physiological saline as a receptor solution, and Labskin (Hos: HR-1 (hairless)). The skin on the back of the mouse) was placed and acclimated at 32 ° C. for 30 minutes. Then, 20 μL of each sample shown in Examples and Comparative Examples in Table 1 was applied onto the lab skin (0.8 cm ² ) and shaken at 32 ° C. and 150 r / m for 10 hours.
After shaking, the entire amount of the receptor solution was collected, and the concentration of minoxidil diffused in the receptor solution was measured by high performance liquid chromatography (HPLC), and the permeation amount of minoxidil was calculated. The experiment was performed 6 times, and the ratio of the permeation amount of each sample was taken when the permeation amount of Comparative Example 1 in each experiment was 1.0, and the ratio of 4 times excluding the maximum value and the minimum value of each sample. Was taken as transdermal absorbability.
Here, the measurement by HPLC was performed according to the method described in the United States Pharmacopeia (USP Monograph USP40, 2017 edition, pp. 5183-5184).

(2) Hair growth effect The skin in the center of the back of a C3H mouse (male, 8 weeks old, average body weight 35 g) was cut with an electric hair clipper, and then the hair was completely removed with a depilatory. From the next day, 0.03 mL of the hair-growth agent of each case was applied to the skin of the subject once a day. Ten animals in a group were used for one sample. On the 14th day after the start of the experiment, a photograph of the skin of the subject was taken.
Next, the photograph was taken into an image analysis device (software (Software (Adobe Photoshop Elements 9; manufactured by Adobe Systems Co., Ltd.)), and the image was binarized. At this time, the threshold color was black and white, 128 of 256 gradations was the threshold, and the values below that were black. Then, from the area (A) where the hair was first cut and the hair growth area (B),
Hair growth rate (%) = [(B) / (A)] x 100
Was calculated, the average of 10 animals was taken, and the hair growth effect was judged according to the following criteria. A to D were accepted.
A: Hair growth rate 30% or more B: Hair growth rate 25% or more and less than 30% C: Hair growth rate 20% or more and less than 25% D: Hair growth rate 15% or more and less than 20% E: Hair growth rate less than 15%

(3) Stability at low temperature storage (i): Presence or absence of precipitation after 1 month at 15 ° C. The undiluted solution and the propellant were placed in this order in a glass pressure-resistant container, each hair growth agent was adjusted, and the mixture was stored in a constant temperature room at 15 ° C. One month later, the appearance of the hair restorer was visually evaluated at 15 ° C., and the presence or absence of particulate precipitate was evaluated according to the following criteria.
◯: No particulate precipitate is seen ×: Particulate precipitate is seen

(4) Low temperature storage stability (ii): -5 ° C, time until precipitation Put the undiluted solution and the propellant in this order in a glass pressure-resistant container, adjust each hair growth agent, and store in a constant temperature room at -5 ° C. .. The appearance of the hair growth agent was visually evaluated at −5 ° C. every 3 hours for the first 24 hours, then every 1 day, and until 14 days later, and the time point when a particulate precipitate was observed was recorded.

(5) No stickiness The stickiness of the hair and scalp when each hair growth agent was applied was sensory evaluated by 10 specialist panelists based on the tactile sensation of the fingers, and judged according to the following criteria. A to C were accepted. The hair-growth agent was applied in the same manner as described in "(1) Hair-growth effect".
A: 9 or 10 people are evaluated as good (no sticky feeling) B: 7 or 8 people are evaluated as good (no sticky feeling) C: 5 or 6 people are good (no sticky feeling) Evaluation D: 3 or 4 people evaluated as good (no sticky feeling) E: 1 or 2 people evaluated as good (no sticky feeling) F: No panelists evaluated as good (no sticky feeling)

(6) Difficulty of see-through of the scalp Hair of a hair piece (a rubber plate is used for the part corresponding to the scalp, and the hair is transplanted in an area of 6 cm in length and 6 cm in width with a hair length of 10 cm and a hair density of 200 hairs / cm ² ) with a hairbrush. I brushed it lightly and trimmed my hair. Next, 1 mL of each hair-growth agent was taken with a dropper and applied using the dropper so as to be as uniform as possible on the flocked portion (scalp and root portion of the hair) of the hair piece. Then, it was allowed to dry sufficiently for 30 minutes by natural drying. Further, the hair piece was dried upside down with a dryer (Cold air of LCD-1203N manufactured by Wright) for 3 minutes.
After drying, the hair piece was placed on a horizontal surface and photographed from directly above.
Next, the photograph was imported into image analysis device software (Adobe Photoshop Elements 9; manufactured by Adobe Systems Co., Ltd.), and the image was binarized. At this time, the threshold color was black and white, 128 of 256 gradations was the threshold, and the values below that were black.
After that, from the area of the background part (A) and the total area (B),
Skin exposure rate (%) = [(A) / (B)] x 100
Was calculated and judged according to the following criteria. A to D were accepted.
A: Skin exposure rate less than 20% B: Skin exposure rate 20% or more and less than 23% C: Skin exposure rate 23% or more and less than 26% D: Skin exposure rate 26% or more and less than 29% E: Skin exposure rate 29% or more 32 Less than% F: Skin exposure rate 32% or more

In Tables 1 and 2, the following components were used.
* 1 PEG20000: Macrogol 20000, manufactured by Sanyo Chemical Industries, Ltd. (average molecular weight 20000)

From Tables 1 and 2, the hair-growth agents of each example have transdermal absorbability or hair-growth effect, storage stability at low temperatures (15 ° C. and -5 ° C.), and no stickiness as compared with those of each comparative example. , And the effect of suppressing see-through of the scalp was excellent.

Claims (7)

A hair restorer that contains undiluted solution and carbon dioxide.
The undiluted solution contains the following components (A) to (C) and (E) :
(A) Minoxidil of 0.7% (mass / volume) or more and 10% (mass / volume) or less with respect to the undiluted solution.
(B) 40% (mass / volume) or more of ethanol with respect to the undiluted solution ,
( C) Water and
(E) Polyethylene glycol having an average molecular weight of 8,000 or more and 50,000 or less
Including
The mass ratio ((E) / (A)) of the content of the component (E) to the content of the component (A) in the stock solution is 0.01 or more and 1 or less.
A hair restorer containing 0.5% (mass / volume) or more and 5% (mass / volume) or less of the carbon dioxide with respect to the undiluted solution. The hair restorer according to claim 1, further comprising (D) a polyhydric alcohol having a molecular weight of 60 or more and 300 or less in an amount of 0.5% (mass / volume) or more and 20% (mass / volume) or less with respect to the undiluted solution. The hair restorer according to claim 1 or 2, which contains the component (E ) in an amount of 0.05% (mass / volume) or more and 2% (mass / volume) or less with respect to the undiluted solution. Further, any one of claims 1 to 3 containing (F) an alkyl glyceryl ether having 16 or more and 22 or less carbon atoms in an amount of 0.1% (mass / volume) or more and 1% (mass / volume) or less with respect to the stock solution. The hair restorer described in the section. Further, any of claims 1 to 4, wherein (G) an organic acid or an inorganic acid having 2 or more and 6 or less carbon atoms is contained in an amount of 0.01% (mass / volume) or more and 1% (mass / volume) or less with respect to the undiluted solution. The hair restorer according to item 1. Further, it is claimed that at least one selected from the group consisting of (H) tocopherol and tocopherol ester is contained in an amount of 0.01% (mass / volume) or more and 0.5% (mass / volume) or less with respect to the undiluted solution. The hair restorer according to any one of 1 to 5. The hair restorer according to any one of claims 1 to 6, wherein the pH at 25 ° C. is 5.0 to 9.0.