JP7119482B2 - Biological information measuring device and biological information measuring program - Google Patents

Description

The present invention relates to a biological information measuring device and a biological information measuring program.

Patent Literature 1 discloses a signal acquisition unit that acquires an airflow signal indicating temporal changes in respiratory airflow and an oxygen saturation signal indicating temporal changes in oxygen saturation, a first time in the airflow signal, and the second A circulation time measuring device having a circulation time calculator for measuring the oxygen circulation time of blood based on the time difference from the second time in the oxygen saturation signal indicating the increase in oxygen saturation corresponding to the resumption of breathing at one time. is disclosed.

Retable No. 2015-190413

2. Description of the Related Art In recent years, development of measurement methods for measuring biological information using an oxygen circulation time, which indicates the time required for oxygen taken into the body to be transported to a predetermined site, has been advanced.

Conventional measurement of the oxygen circulation time utilizes the period in which the person to be measured is in an apnea state during sleep, and detects the respiratory state of the person to be measured by means of an airflow sensor or the like attached to the nose or mouth of the person to be measured. It was done by detecting with

However, the frequency and duration of apnea during sleep varies among subjects. Therefore, in order to measure the oxygen circulation time in a more stable state, it is necessary to keep the subject in an awake state. Measurements should be taken.

In this case, a detection means such as an airflow sensor is attached to the nostrils of an awake subject to detect the respiratory state of the subject. Compared to , the burden on the person to be measured is increased.

An object of the present invention is to provide a biological information measuring device and a biological information measuring program capable of measuring the oxygen circulation time of a subject without detecting the respiratory state of the subject.

In order to achieve the above object, the invention of a biological information measuring apparatus according to claim 1 is provided with a prompting means for prompting a person to be measured to resume breathing when the measurement time in the measuring apparatus reaches a specified time; notification means for notifying that the respiration of the subject has resumed; and from the time when the respiration of the subject has resumed, the change in blood oxygen concentration at a predetermined site of the subject from a decrease to an increase. measuring means for measuring an oxygen circulation time until an inflection point appears , wherein the prescribed time is adjusted based on information on the age, sex and physical condition of the subject .

In the invention according to claim 2 , the notifying means is configured to prompt the person to be measured to resume the breathing from an input device operated by the person to be measured or by a person who measures the biological information of the person to be measured. When the instruction to notify is received, it is notified that the breathing of the person to be measured has resumed .

In the invention according to claim 3, the notifying means notifies that the person to be measured has resumed breathing when the time measured by the measuring device reaches the specified time representing the stoppage period of breathing. .

According to a fourth aspect of the invention, the measuring means starts measuring time when an instruction to notify the subject of resuming breathing is received from the input device, and during the time measurement When the inflection point of the oxygen concentration in the blood of the person appears, the accumulated time from the reception of the instruction to notify the respiration of the person to be measured from the input device until the appearance of the inflection point to measure the oxygen circulation time.
According to a fifth aspect of the present invention, the measuring means starts measuring time when the time measured by the measuring device reaches the specified time, and measures the amount of oxygen in the blood of the person to be measured during the time measurement. When the concentration inflection point appears, the oxygen circulation time is measured using the accumulated time from when the measurement time in the measuring device reaches the specified time until the inflection point appears.

According to a sixth aspect of the present invention, the measuring means measures a time obtained by subtracting a predetermined time from the accumulated time as the oxygen circulation time.

In the invention according to claim 7 , the measuring means acquires the time at which it is accepted that the respiration of the person to be measured has resumed from the notification means, and the acquired time at which it is accepted that the respiration has resumed and the The oxygen circulation time is measured using the difference from the appearance time of the inflection point.

According to an eighth aspect of the invention, the measuring means detects the inflection point from a change in blood oxygen concentration of the person to be measured, and the time at which the inflection point is detected is the time of the inflection point. The oxygen circulation time is measured as appearance time.

According to a ninth aspect of the invention, the measurement means stores the oxygen concentration for each hour in a storage device over a predetermined period, and the inflectional value obtained from the oxygen concentration for each hour stored in the storage device The oxygen circulation time is measured by taking the time corresponding to the point as the appearance time of the inflection point.

According to a tenth aspect of the present invention, the measuring means measures the time obtained by subtracting a predetermined time from the difference between the time at which the subject's respiration is resumed and the appearance time of the inflection point. Measured as circulation time.

In the invention according to claim 11 , the measuring means acquires the inflection point using the oxygen saturation indicating the oxygen concentration in the blood of the person to be measured, and measures the oxygen circulation time.

In the invention according to claim 1 or 2 , the measuring means acquires the inflection point using the oxygen saturation indicating the oxygen concentration in the blood of the finger of the person to be measured, and measures the oxygen circulation time.

The invention according to claims 1 to 3 further comprises an input device for receiving the operation of the person to be measured or by the measurer who measures the biological information of the person to be measured, and a display device for displaying that the prescribed time has elapsed. , provided.

The invention of the biological information measuring program according to claims 1 to 4 causes a computer to function as each means of the biological information measuring apparatus according to any one of claims 1 to 13.

According to the inventions of claims 1 and 14, there is an effect that the oxygen circulation time of the subject can be measured without detecting the subject's respiratory condition.

According to the second aspect of the invention, it is possible to measure the oxygen circulation time of the person to be measured according to the instruction of the person to be measured or the person who measures the biological information of the person to be measured.

According to the third aspect of the present invention, it is possible to measure the oxygen circulation time of the person to be measured in accordance with the end of the breathing stop period.

According to the inventions of claims 4 and 5 , there is an effect that the oxygen circulation time of the person to be measured can be measured using a timer that measures the accumulated time.

According to the invention of claim 6 , compared to the case where the cumulative time from receiving the instruction to start measuring time to detecting the inflection point of the oxygen concentration is the oxygen circulation time, the measured person's It has the effect of being able to accurately measure the oxygen circulation time.

According to the seventh aspect of the invention, it is possible to measure the oxygen circulation time of the subject using a clock that measures absolute time.

According to the eighth aspect of the invention, it is possible to measure the oxygen circulation time of the subject while measuring the oxygen concentration.

According to the ninth aspect of the present invention, it is possible to measure the oxygen circulation time of the person to be measured even after the measurement of the oxygen concentration is completed.

According to the tenth aspect of the present invention, compared to the case where the difference between the reception time of the instruction to start measuring the time and the appearance time of the inflection point of the oxygen concentration is set as the oxygen circulation time, the oxygen concentration of the subject is reduced. It has an effect that the circulation time can be measured with high accuracy.

According to the invention of claim 11 , there is an effect that the oxygen circulation time can be measured using the oxygen saturation.

According to the invention described in claims 1 and 2 , compared with the case of using the oxygen saturation in the blood of the part closer to the lung than the finger, the oxygen circulation time can be measured with high accuracy. have

According to the invention described in claims 1 to 3 , if there is a biological information measuring device, it is possible to accept an operation without separately preparing an input device and a display device, and to display that the specified time has been reached. have an effect.

FIG. 4 is a schematic diagram showing an example of measuring oxygen saturation in blood. 4 is a graph showing an example of change in the amount of light absorbed by a living body. FIG. 3 is a diagram showing an example of the light absorption amount for each wavelength of oxygenated hemoglobin and reduced hemoglobin; BRIEF DESCRIPTION OF THE DRAWINGS It is a figure which shows the structural example of the biological information measuring device which concerns on 1st Embodiment. It is a figure which shows the example of arrangement|positioning of a light emitting element and a light receiving element. FIG. 10 is a diagram showing another arrangement example of light emitting elements and light receiving elements; FIG. 4 is a diagram showing an example of changes in oxygen saturation in blood due to stopping and resuming of breathing. It is a figure which shows the principal part structural example of the electrical system in a biological information measuring device. 4 is a flowchart showing an example of the flow of biological information measurement processing according to the first embodiment; It is a figure which shows the structural example of the biological information measuring device which concerns on 2nd Embodiment. It is a flow chart which shows an example of the flow of living body information measuring processing concerning a 2nd embodiment.

Hereinafter, this embodiment will be described with reference to the drawings. Components and processes having the same function are given the same reference numerals throughout the drawings, and redundant explanations are omitted.

<First Embodiment>
The biological information measuring apparatus 10 is an apparatus for measuring biological information particularly concerning the circulatory system among the information (biological information) concerning the living body 8 . The circulatory system is a general term for a group of organs for circulating and transporting body fluids such as blood in the body.

There are multiple indicators of biological information related to the circulatory system. One of the indicators that indicates the state of the heart, which pumps blood into the blood vessels, is the cardiac output (CO: Cardiac Output).

Cardiac output is known to be suspected of left heart failure, for example, when cardiac output falls below the reference value, and right heart failure, for example, when cardiac output increases above the reference value. It is used to check for heart disease or to confirm the effect of medication.

As a method for measuring cardiac output, for example, a catheter with a balloon at the tip is inserted into the pulmonary artery of a person to be measured, and oxygen in the blood is measured while inflating and deflating the balloon. A method of measuring saturation and calculating cardiac output from the measured oxygen saturation is used. Here, the blood oxygen saturation is an example of an index that indicates the oxygen concentration in the blood, and is an index that indicates how much hemoglobin in the blood is bound to oxygen. It indicates that symptoms such as anemia tend to occur as the level decreases.

However, the method of measuring cardiac output using a catheter requires surgical treatment because it is necessary to insert the catheter into the blood vessel of the subject, and is more invasive to the subject than other measurement methods. get higher

Therefore, a method of measuring cardiac output using the oxygen saturation obtained from the subject's pulse wave is proposed so as to reduce the burden on the subject compared to the method of measuring cardiac output using a catheter. being studied. A pulse wave is an index that indicates changes in blood vessel pulsation associated with blood pumping by the heart.

First, a method for measuring oxygen saturation in blood among biometric information will be described with reference to FIG.

As shown in FIG. 1, the oxygen saturation in the blood is measured by irradiating light from the light emitting element 1 toward the body (living body 8) of the person to be measured and receiving the light by the light receiving element 3. It is measured using the intensity of light reflected or transmitted by the arteries 4, veins 5, capillaries 6, etc., that is, the amount of received reflected light or transmitted light.

FIG. 2 is a conceptual diagram showing the amount of change in the amount of light absorbed by the living body 8, for example. As shown in FIG. 2, the amount of light absorbed by the living body 8 tends to fluctuate over time.

Furthermore, looking at the details of the variation in the amount of light absorption in the living body 8, the amount of light absorption varies mainly due to the artery 4, and the amount of light absorption does not vary in other tissues including veins 5 and stationary tissues compared to the artery 4. It is known that the amount of variation is such that it can be regarded as This is because the arterial blood pumped from the heart moves in the blood vessel with pulse waves, so the artery 4 expands and contracts over time along the cross-sectional direction of the artery 4, and the thickness of the artery 4 changes. . In FIG. 2, the range indicated by the arrow 94 indicates the amount of change in the amount of light absorption corresponding to the change in the thickness of the artery 4. As shown in FIG.

In FIG. 2, if the amount of light received at time t _a is I _a and the amount of light received at time t _b is I _b , the amount of change ΔA in the amount of light absorption due to the change in thickness of the artery 4 can be expressed by equation (1). be done.

(Number 1)
ΔA=ln(I _b /I _a ) (1)

On the other hand, FIG. 3 is a diagram showing an example of the amount of light absorbed for each wavelength of hemoglobin bound to oxygen (oxygenated hemoglobin) and hemoglobin not bound to oxygen (reduced hemoglobin) flowing in the artery 4 . In FIG. 3, a graph 96 represents the amount of light absorbed by oxygenated hemoglobin, and a graph 97 represents the amount of light absorbed by reduced hemoglobin.

As shown in FIG. 3, oxidized hemoglobin is more likely to absorb light in the infrared (IR) region 99 having a wavelength around about 850 nm than deoxyhemoglobin, and reduced hemoglobin is particularly It is known to be sensitive to light in the red region 98 having wavelengths around about 660 nm.

Furthermore, it is known that the oxygen saturation has a proportional relationship with the ratio of the amount of change ΔA in the amount of light absorption at different wavelengths.

Therefore, compared to other wavelength combinations, infrared light (IR light) and red light are more likely to cause a difference in the amount of light absorption between oxygenated hemoglobin and reduced hemoglobin. By calculating the ratio between the amount of change ΔA _IR and the amount of change ΔA _Red in the amount of absorption when the living body 8 is irradiated with red light, the oxygen saturation S is calculated by the equation (2). Note that k in (2) is a constant of proportionality.

(Number 2)
S=k(ΔA _Red /ΔA _IR ) (2)

That is, when calculating the oxygen saturation in blood, the living body 8 is irradiated with a plurality of light-emitting elements 1 that emit light of different wavelengths. Specifically, the light-emitting element 1 that emits IR light and the light-emitting element 1 that emits red light are used for the living body 8 . In this case, the light emission period of the light emitting element 1 that emits IR light and the light emitting element 1 that emits red light may overlap. Then, the reflected light or transmitted light from each light emitting element 1 is received by the light receiving element 3, and the amount of light received at each light receiving time is obtained by formulas (1) and (2), or by modifying these formulas. Oxygen saturation is measured by calculating a known formula.

As a known formula obtained by modifying the above formula (1), for example, formula (1) may be developed to express the amount of change ΔA in the amount of light absorption as in formula (3).

(Number 3)
ΔA= _lnIb - _lnIa (3)

Also, equation (1) can be transformed into equation (4).

(Number 4)
ΔA=ln( _Ib / _Ia )=ln(1+( _Ib - _Ia )/ _Ia ) (4)

Since (I _b -I _a )<<I a, ln(I _b /I _a )≈ _{(I b -I a} )/I _a is usually established. Equation (5) may be used as the amount of change ΔA in the amount of light absorption.

(Number 5)
ΔA≈(I _b −I _a )/I _a (5)

Hereinafter, when it is necessary to distinguish between the light-emitting element 1 that emits IR light and the light-emitting element 1 that emits red light, the light-emitting element 1 that emits IR light will be referred to as "light-emitting element 1A" and red light. The light-emitting element 1 that irradiates is referred to as "light-emitting element 1B".

According to this method, the oxygen saturation in the blood is measured by bringing the light emitting element 1 and the light receiving element 3 close to the body surface of the person to be measured. The burden on the person to be measured is less than the measurement.

Then, using the measured oxygen saturation of the subject, the biological information measuring device 10 calculates the cardiac output by a method described later.

FIG. 4 is a diagram showing a configuration example of the biological information measuring device 10. As shown in FIG. As shown in FIG. 4, the biological information measuring device 10 includes a photoelectric sensor 11, a pulse wave processing unit 12, a reception unit 13, an oxygen saturation measurement unit 14, a timer 15, a notification unit 16, an oxygen circulation time measurement unit 17, and a heart sensor. A stroke volume measurement unit 18 is included.

The photoelectric sensor 11 includes a light-emitting element 1A that emits IR light with a central wavelength of about 850 nm, a light-emitting element 1B that emits red light with a central wavelength of about 660 nm, and receives IR light and red light. A light receiving element 3 is provided.

FIG. 5 shows an arrangement example of the light emitting element 1A, the light emitting element 1B, and the light receiving element 3 in the photoelectric sensor 11. As shown in FIG. As shown in FIG. 5, the light-emitting element 1A, the light-emitting element 1B, and the light-receiving element 3 are arranged side by side toward one surface of the living body 8. As shown in FIG. In this case, the light receiving element 3 receives IR light and red light reflected by the capillaries 6 and the like of the living body 8 .

However, the arrangement of the light emitting element 1A, the light emitting element 1B, and the light receiving element 3 is not limited to the arrangement example of FIG. For example, as shown in FIG. 6, the light-emitting elements 1A and 1B and the light-receiving element 3 may be arranged at positions facing each other with the living body 8 interposed therebetween. In this case, the light receiving element 3 receives IR light and red light that have passed through the living body 8 .

Here, as an example, the light emitting elements 1A and 1B are described as surface emitting laser elements such as VCSEL (Vertical Cavity Surface Emitting Laser), but they may be edge emitting laser elements. Also, the light emitting elements 1A and 1B may be LEDs (Light Emitting Diodes).

The photoelectric sensor 11 is provided with a clip (not shown) for attaching the photoelectric sensor 11 to a part of the subject's body. is attached to the subject's body surface by a clip (not shown). In order for the light-receiving element 3 to receive the IR light and red light reflected or transmitted by the subject's living body 8 as accurately as possible, it is preferable to arrange the photoelectric sensor 11 so as to be in contact with the subject's body surface. However, the photoelectric sensor 11 is placed on the body surface within a range where the IR light and red light reflected by the subject's living body 8 or the IR light and red light transmitted through the subject's living body 8 are received by the light receiving element 3. It can be installed in a position away from the

The photoelectric sensor 11 converts the received amounts of the IR light and the red light received by the light receiving element 3 into, for example, voltage values and notifies the pulse wave processing unit 12 of the voltage values.

Since the light-emitting elements 1A and 1B emit predetermined amounts of light, the absorption amounts of the IR light and the red light in the living body 8 can be calculated from the amounts of the IR light and the red light received by the photoelectric sensor 11. can get.

Therefore, the pulse wave processing unit 12 uses the received amounts of the IR light and the red light received from the photoelectric sensor 11 to obtain a pulse wave signal representing the subject's pulse wave obtained from the IR light and the infrared light. A pulse wave signal representing the subject's pulse wave obtained from the light is generated. The pulse wave processing unit 12 amplifies the voltage values so that the voltage values corresponding to the received amounts of the received IR light and red light fall within a predetermined range suitable for pulse wave signal generation. Then, the pulse wave processing unit 12 generates respective pulse wave signals from which noise components are removed using a known filter or the like.

The pulse wave processing unit 12 notifies the oxygen saturation measurement unit 14 of each generated pulse wave signal.

Upon receiving the pulse wave signal from the pulse wave processing unit 12, the oxygen saturation measuring unit 14 measures the oxygen saturation of the subject from the received pulse wave signal. Specifically, the oxygen saturation measuring unit 14 uses the pulse wave signal to measure the amount of change ΔA _IR in the amount of absorption of IR light due to the change in the thickness of the artery 4 and the amount of change ΔA _Red in the amount of absorption of red light. Each is calculated according to the formula (1). Then, the oxygen saturation measuring unit 14 measures the oxygen saturation of the subject from, for example, equation (2) using the calculated amount of change ΔA _IR and amount of change ΔA _Red , and measures the measured oxygen saturation as oxygen circulation. The time measurement unit 17 is notified.

Hereinafter, as an example, an example in which the oxygen saturation measuring unit 14 measures the oxygen saturation of the subject will be described. Any value can be measured. For example, the oxygen saturation measuring unit 14 may measure a value that correlates with the change in oxygen saturation over time, such as the reciprocal of the oxygen saturation or the ratio of the amount of change ΔA _Red and the amount of change _ΔAIR .

The receiving unit 13 is an example of receiving means for receiving the respiratory state of the person being measured. Specifically, when receiving an instruction to notify the person to stop breathing via an input device operated by the subject or a measurer such as a medical professional who measures the biological information of the subject, the reception unit 13 Assume that the subject has stopped breathing. Further, when receiving an instruction to notify that breathing has resumed from the input device, the reception unit 13 considers that the subject's breathing has resumed.

Then, the reception unit 13 notifies the notification unit 16 of the measurement subject's respiratory state, for example, breathing stops and breathing restarts.

Hereinafter, the person to be measured and the measurer such as a medical professional who measures the biological information of the person to be measured will be referred to as the "user of the biological information measuring device 10".

The timer 15 is an example of a measuring device that measures time, and measures the cumulative time from a specified time.

When receiving unit 13 notifies that the person to be measured has stopped breathing, notification unit 16 starts timer 15, and when the breathing stop period reaches a predetermined time, the person to be measured stops breathing. Send a resume notification telling you to resume breathing.

The graph of FIG. 7 shows an example of change in blood oxygen saturation at a specific site of the subject, where the horizontal axis represents time and the vertical axis represents the reciprocal of oxygen saturation.

When the subject stops breathing at time t ₀ , the oxygen saturation in the subject's blood begins to decrease. Even if the person to be measured resumes breathing after the lapse of a predetermined time (time t ₁ ) as the period during which the person to be measured stops breathing, the oxygen taken into the blood by the resumption of breathing cannot be identified from the lungs. Since it takes time to reach the site of , the oxygen saturation in the blood of the subject decreases even after time t ₁ . In the meantime, the oxygen taken into the blood by resuming breathing reaches a specific part from the lungs, so the oxygen saturation in the blood of the person to be measured starts to increase. The point where blood oxygen saturation changes from decreasing to increasing is called an "inflection point", and if the _time when the inflection _point appears is time t2, the oxygen circulation time is the difference between _time t1 and time t2. represented by

That is, the oxygen circulation time represents the time required for oxygen to be transported from the lungs to a specific site, and is also called "oxygen transport time."

Since the oxygen circulation time measured from the oxygen saturation tends to vary in measurement accuracy due to variations in the breathing stop period, a specified time is provided that defines the breathing stop period.

The specified time is determined in advance by experiments using the actual biological information measuring device 10 or computer simulations based on the design specifications of the biological information measuring device 10 so that the measurement accuracy of the oxygen circulation time in the biological information measuring device 10 is high. is the value

Therefore, the notification unit 16 notifies the person to be measured of the resumption of respiration so that the period of respiration of the person to be measured approaches the specified time. The circulation time measurement unit 17 is also notified that the subject's breathing has resumed.

When the oxygen circulation time measurement unit 17 receives from the notification unit 16 that the measurement subject has resumed breathing, it stores the time at which the respiration was received as time t ₁ . Then, the oxygen circulation time measurement unit 17 monitors the oxygen saturation measured by the oxygen saturation measurement unit 14 and detects an inflection point of the oxygen saturation. The oxygen circulation time measurement unit 17 stores the time when the inflection _point of the oxygen saturation is detected as _time t2, and measures the time represented by the difference between _time t1 and time t2 as the oxygen circulation time. Note that "detecting an inflection point" includes detecting a position slightly deviated from the inflection point within a range that does not substantially affect the measurement of the oxygen circulation time.

Then, the oxygen circulation time measurement unit 17 notifies the cardiac output measurement unit 18 of the measured oxygen circulation time. Thus, the oxygen circulation time measuring unit 17 is an example of measuring means for measuring the oxygen circulation time.

The measurement site of the oxygen circulation time is determined by the attachment position of the photoelectric sensor 11 on the subject. In this embodiment, as an example, the photoelectric sensor 11 is attached to the peripheral site of the subject. More specifically, it is worn on a fingertip, and the oxygen circulation time is measured when oxygen is transported from the lungs to the fingertip. This is because the oxygen circulation time is longer due to the longer distance from the lungs compared to other parts, so the oxygen circulation time is more accurate than when the photoelectric sensor 11 is attached to other parts. Because it can be obtained. The term "peripheral site" refers to a site on the peripheral side of the neck, shoulders, and hip joints of the subject's body.

Therefore, the oxygen circulation time from the lungs to the fingertips is sometimes called LFCT (Lung to Finger Circulation Time). In the present embodiment as well, an example in which the photoelectric sensor 11 is attached to the fingertip of the person to be measured and the oxygen circulation time measurement unit 17 measures the LFCT will be described, but the location where the photoelectric sensor 11 is attached is not limited to the fingertip. The photoelectric sensor 11 may be attached to any part of the person to be measured as long as the measurement error of the obtained oxygen circulation time is within a predetermined range. The "fingertip" refers to the fingertip of the hand of the subject, but the photoelectric sensor 11 may be attached to the toe of the subject.

The cardiac output measurement unit 18 uses the LFCT received from the oxygen circulation time measurement unit 17 to measure the cardiac output of the subject. Cardiac output is calculated, for example, by a previously determined arithmetic expression representing the relationship between LFCT and cardiac output.

Note that the cardiac output measurement unit 18 may measure information related to the cardiac output in addition to the cardiac output. "Information about cardiac output" is information that is correlated with cardiac output, and includes, for example, cardiac index and stroke volume.

The "cardiac coefficient" is a value obtained by dividing the cardiac output of a person to be measured by the body surface area of the person to be measured in order to correct the difference in cardiac output due to the difference in body size of the person to be measured. The "stroke volume" is a value indicating the amount of blood pumped out to the artery 4 by one contraction of the heart. It is required by

The biological information measuring device 10 described above is configured using a computer, for example. FIG. 8 is a diagram showing a configuration example of a main part of an electrical system in the biological information measuring device 10 configured using the computer 20. As shown in FIG.

The computer 20 includes a CPU (Central Processing Unit) 21, a ROM (Read Only Memory) 22, a RAM (Random Access Memory) 23, a nonvolatile memory 24, and an input/output An interface (I/O) 25 is provided. A CPU 21, a ROM 22, a RAM 23, a nonvolatile memory 24, and an I/O 25 are connected via a bus 26, respectively. Note that there is no limit to the operating system used by the computer 20 .

The nonvolatile memory 24 is an example of a storage device that maintains stored information even when the power supplied to the nonvolatile memory 24 is interrupted. For example, a semiconductor memory is used, but a hard disk may also be used.

The photoelectric sensor 11, the input unit 27, the display unit 28, and the communication unit 29 are connected to the I/O 25, for example.

The photoelectric sensor 11 is connected to the I/O 25 by wire or wirelessly. In addition, the biological information measuring device 10 and the photoelectric sensor 11 may be configured separately so that the biological information measuring device 10 and the photoelectric sensor 11 are separated. They may be housed in the same housing.

The input unit 27 is, for example, a unit that receives an instruction from the user of the biological information measuring device 10 and notifies the CPU 21 of it. The input unit 27 includes, for example, buttons, a touch panel, a keyboard, a mouse, and the like. As an example, the input unit 27 includes a button for notifying to stop breathing and a button for notifying to resume breathing.

Therefore, the user of the biological information measuring device 10 presses the button to notify the biological information measuring device 10 of stopping breathing and resuming breathing. Hereinafter, the button for notifying the user to stop breathing will be referred to as the "stop breathing button", and the button for notifying the user to resume breathing will be referred to as the "resume breathing button".

It should be noted that it is not always necessary to notify the CPU 21 of stopping and resuming breathing by pressing a touch panel, pressing a keyboard, or operating a mouse, for example.

The display unit 28 is a unit that visually displays the information processed by the CPU 21 to the user of the biological information measuring device 10, for example. A display device such as a liquid crystal display, an organic EL (Electro Luminescence), or a projector is used for the display unit 28 .

Note that the display unit 28 is not necessarily a unit necessary for the biological information measuring device 10, and may notify the user of the biological information measuring device 10 of information notified from the biological information measuring device 10, such as notification of resuming breathing. Any type of unit may be connected to I/O 25 .

For example, when notifying the user of the biological information measuring device 10 of information notified from the biological information measuring device 10 by voice, instead of the display unit 28, for example, a speaker unit may be connected. In addition, when notifying the user of the biological information measuring device 10 of the information notified from the biological information measuring device 10 through bodily sensation, instead of the display unit 28, for example, a vibration unit may be connected. Furthermore, the user of the biological information measuring device 10 may be notified of the information notified from the biological information measuring device 10 using a plurality of units such as the display unit 28 and the speaker unit.

The communication unit 29 has a communication protocol for connecting a communication line such as the Internet and the biological information measuring apparatus 10, and performs data communication between the biological information measuring apparatus 10 and other external devices connected to the communication line. The form of connection to the communication line in the communication unit 29 may be wired or wireless. The communication unit 29 does not necessarily need to be connected to the I/O 25 if the biological information measurement device 10 does not need to perform data communication with other external devices connected to the communication line.

Note that the units connected to the I/O 25 are not limited to the examples described above, and other units such as a printing unit may be connected to the I/O 25 .

Next, the operation of the biological information measuring device 10 will be described with reference to FIG.

FIG. 9 shows a state in which the photoelectric sensor 11 is attached to the fingertip of the person to be measured, and the CPU 21 executes a measurement instruction of the cardiac output through the input unit 27 from the user of the biological information measuring device 10. 4 is a flowchart showing an example of the flow of biological information measurement processing performed. Upon receiving the instruction to measure the cardiac output, the biological information measuring apparatus 10 continues to measure the oxygen saturation of the subject at least until the measurement of the cardiac output is completed.

A biological information measurement program that defines the biological information measurement process is pre-stored in the ROM 22 of the biological information measurement device 10, for example. The CPU 21 of the biological information measurement device 10 reads the biological information measurement program stored in the ROM 22 and executes the biological information measurement process.

First, in step S10, the CPU 21 determines whether or not the subject has stopped breathing, depending on whether or not the breathing stop button included in the input unit 27 has been pressed.

If the breathing stop button has not been pressed, that is, if the subject has not stopped breathing yet, the process of step S10 is repeatedly executed to monitor the pressing status of the breathing stop button.

On the other hand, if the breathing stop button is pressed, that is, if it is determined that the subject has stopped breathing, the process proceeds to step S20.

In step S20, the CPU 21 activates the timer 15 to start measuring the breath stop period. Here, there is no limitation to the method of measuring the period of respiratory arrest. An external timer unit connected to I/O 25 may be used to measure the breath-hold period.

In step S30, the CPU 21 refers to the timer value of the timer 15 and determines whether or not the breathing stop period has reached a specified time. If the breathing stop period has not reached the specified time, the process of step S30 is repeatedly executed to monitor the breathing stop period of the subject. On the other hand, when the breathing stop period reaches the specified time, the process proceeds to step S40.

In this case, in order to restart the subject's breathing, the CPU 21 notifies the subject of a respiration resumption notification to the subject in step S40. Specifically, when the display unit 28 is connected to the biological information measurement device 10, the CPU 21 displays, for example, a message or a diagram prompting the user to resume breathing on the display unit 28. FIG. In addition, when a speaker unit is connected to the biological information measuring device 10, the CPU 21 outputs, for example, a voice prompting the user to resume breathing from the speaker unit.

In step S50, the CPU 21 determines whether or not the subject has resumed breathing, depending on whether or not the respiration button included in the input unit 27 has been pressed.

If the breathing restart button has not been pressed, that is, if the subject has not restarted breathing yet, the process of step S50 is repeatedly executed to monitor the pressing status of the breathing restart button.

On the other hand, if the respiration button has been pressed, that is, if it is determined that the person to be measured has resumed breathing, the process proceeds to step S60.

In step S40, the subject was notified of the resumption of breathing in accordance with the timing when the breathing stop period reached the specified time. There may be a delay between being notified and actually resuming breathing. Therefore, the CPU 21 sequentially displays the remaining time until the specified time is reached on the display unit 28 in order to inform the person to be measured how much more breathing should be stopped during the period of stopping breathing. The patient may be notified in advance when the period of respiratory arrest will end.

As the person to be measured resumes breathing, in step S60, the CPU 21 acquires the time t _{1 at which the person to be measured has resumed breathing, and stores the acquired time t 1 in} the RAM 23, which is an example of a storage device. Remember.

Here, there is no limitation on the method of acquiring the time information. The time information may be obtained from an external clock unit connected to /O25. Also, the CPU 21 may acquire time information from a time server, which is an example of an external device connected to a communication line, via the communication unit 29 .

Note that the time point at which resuming of breathing is detected does not mean only one point at the moment when resuming of breathing is detected, but a predetermined period after the time when resuming of breathing is detected, or signal processing related to detection. It refers to the period including the delay time etc. during which the Further, since the time at which the subject resumes breathing is measured by pressing the resuming breathing button, pressing the resuming breathing button by the user of the biological information measuring apparatus 10 is an example of a measurement instruction.

In step S70, the CPU 21 refers to the oxygen saturation obtained from the pulse wave signal detected by the photoelectric sensor 11 to determine whether or not the inflection point of the oxygen saturation has been detected, in other words, the oxygen saturation has decreased. It is determined whether or not recovery has occurred.

If the oxygen saturation continues to decrease and the inflection point is not detected, the process of step S70 is repeatedly executed to monitor changes in the oxygen saturation. On the other hand, when the inflection point of the oxygen saturation is detected, the process proceeds to step S80.

In step S<_{b>80 , the CPU 21 acquires the time t 2 when the inflection point of the oxygen saturation is detected, and stores the acquired time t 2 in} the RAM 23 . Since the time t2 is the _time when the inflection point of the oxygen saturation appears, it is also called the "appearance time of the inflection point". The point at which the oxygen saturation inflection point is detected does not mean only one point at the moment when the oxygen saturation inflection point is detected, but the point after the time when the oxygen saturation inflection point is detected. It refers to a predetermined period and a period including a delay time during which signal processing related to detection is performed.

The CPU 21 acquires the difference between the time t ₂ and the time t ₁ stored in the RAM 23 in step S60 as the LFCT.

In step S90, the CPU 21 uses the LFCT acquired in step S80 to measure the cardiac output from, for example, equation (6). Furthermore, the CPU 21 may calculate information about the cardiac output using the measured cardiac output.

With the above, the biological information measurement process shown in FIG. 9 ends.

The duration of respiratory cessation during which LFCT can be measured with high accuracy varies, for example, depending on the subject's age, sex, physical condition, and the like. Therefore, based on the information of the person to be measured set in the biological information measuring device 10 by the user of the biological information measuring device 10 via the input unit 27, the CPU 21 sets the specified period of time for each person to be measured that defines the period of stopping breathing. can be adjusted to Also, the user of the biological information measuring device 10 may adjust the prescribed time.

The prescribed time may be set, for example, in units of one second, or may be set as the prescribed time selected from a plurality of times prepared in advance, such as 15 seconds, 20 seconds, and 25 seconds. There is no limit to the setting unit of the prescribed time, and for example, it may be in units of milliseconds or in units of 5 seconds.

The specified time set for each person to be measured is stored, for example, in the non-volatile memory 24, and information identifying the person to be measured, such as the name of the person to be measured or the patient number, is stored in the biometric information measurement prior to the instruction to measure the cardiac output. When input to the device 10, the CPU 21 uses the prescribed time associated with the person to be measured for the determination in step S30 of FIG.

As described above, according to the biological information measuring device 10 according to the first embodiment, the respiratory state of the person to be measured is determined using the pulse wave obtained from the sensor value of the photoelectric sensor 11 according to the instruction from the user of the biological information measuring device 10 . And the blood oxygen saturation is measured, and the cardiac output is measured from the subject's respiratory condition and blood oxygen saturation.

Various modifications are applied to the biological information measurement process shown in FIG.

As shown in step S50 in FIG. 9, the CPU 21 waits for the user of the biological information measuring device 10 to press the breathing restart button before starting LFCT measurement. However, if there is a delay in the period from when the biological information measuring device 10 notifies the subject of the resumption of breathing notification to when the respiration button is pressed, the respiration stop period becomes longer than the specified time, and respiration is stopped. The measurement accuracy of LFCT may be lower than when the stop period is adjusted to the specified time.

Therefore, the CPU 21 may measure the LFCT when the period from notification of resumption of breathing to resumption of respiration of the subject is within an allowable delay period, which is a predetermined period. . In other words, the CPU 21 suspends execution of the processing from step S60 in FIG. , the biological information measurement process shown in FIG. 9 may be terminated without measuring the LFCT.

Further, in the biological information measurement process described above, the LFCT was measured from the difference between the time t ₁ at which resuming of breathing in the subject was detected and the time t ₂ at which the inflection point of the oxygen saturation appeared. _The timer 15 may be restarted instead of storing the time t1 in step S60 of FIG. 9, and the timer 15 may be stopped instead of storing the _time t2 at which the inflection point appears in step S80. In this case, the accumulated time measured by the timer 15 from when the respiration button is pressed by the user of the biological information measuring device 10 to when the oxygen saturation inflection point appears may be obtained as the LFCT.

Conversely, in the above-described biological information measurement process, the timer 15 is used to measure the period during which the subject's breathing stops, but the absolute time may be used to measure the period during which the subject's breathing stops. For example, the CPU 21 stores in the RAM 23 the time t ₀ at which the breathing stop button was pressed instead of activating the timer 15 in step S20 of FIG. It may be determined whether or not the difference from the time t ₀ obtained has reached a specified time.

In addition, the person to be measured may not resume breathing when the breathing resume button is pressed, but may resume breathing after a while after pressing the breathing resume button. Therefore, the biological information measuring apparatus 10 may perform LFCT measurement in consideration of the delay time from when the respiration button is pressed until the subject actually resumes respiration.

Specifically, the CPU 21 may acquire, as the final LFCT, a time obtained by subtracting a delay time, which is a predetermined time, from the LFCT acquired in step S80 of FIG. The delay time represents the time from when the respiration button is pressed until the subject actually resumes breathing, and is obtained in advance through experiments using the actual biological information measuring device 10 for a plurality of subjects. is the value

In addition, in the biological information measurement process shown in FIG. 9, the oxygen saturation of the subject at each time is monitored in real time, and the cardiac output of the subject is measured during the measurement of the oxygen saturation. , so-called real-time processing. However, the biological information measuring device 10 does not necessarily need to perform real-time processing of measuring the subject's cardiac output while measuring the oxygen saturation.

For example, the CPU 21 stores in the RAM 23 the oxygen saturation and the time information at each time in a predetermined period after at least the breathing restart button is pressed, in association with each other, and without executing the processing of steps S70 to S90. The biological information measurement process shown in 9 is temporarily terminated.

When the CPU 21 receives a cardiac output measurement instruction from the user of the biological information measuring device 10, the CPU 21 reads from the RAM 23 the oxygen saturation and time information at each time after the respiration button was pressed. After that, the CPU 21 executes the processing of steps S70 to S90 in FIG. 9, detects the inflection point of the oxygen saturation from the readout change in the oxygen saturation, and detects the time when the breathing restart button is pressed, that is, The LFCT is obtained from the difference between the _time t1 when respiration of the subject is detected and the time t2 when the oxygen saturation inflection _point appears, and the cardiac output is measured using the obtained LFCT.

Here, the “predetermined period” is a period set longer than the longest medically conceivable LFCT.

Note that the oxygen saturation level and time information may be stored in the nonvolatile memory 24 . Furthermore, the CPU 21 may store the oxygen saturation and the time information in association with each other in a storage device, which is an example of an external device connected to the communication line, via the communication unit 29 .

In the above example, the oxygen saturation and the time information are stored in the RAM 23 in association with each other. good. In this case, LFCT and cardiac output are measured based on changes in oxygen saturation obtained from pulse wave signals.

As described above, the biological information measuring device 10 according to the first embodiment receives an instruction to notify the respiratory state from the user of the biological information measuring device 10 via the input unit 27 . Then, when the biological information measuring device 10 receives an instruction to notify the resumption of breathing, the biological information measuring apparatus 10 measures the time from the reception of the instruction to the appearance of the inflection point of the oxygen saturation, and measures the oxygen circulation time and the cardiac output. Measure quantity. Therefore, the biological information measuring apparatus 10 measures the oxygen circulation time and cardiac output of the subject without using a detection means such as an airflow sensor for detecting the subject's respiratory condition.

<Second embodiment>
In the biological information measuring device 10 according to the first embodiment, the measurement of the respiratory arrest period and the LFCT are started in accordance with the respiratory state of the subject notified by the user of the biological information measuring device 10 .

In the second embodiment, the measurement subject adjusts the respiratory state to the instruction notified by the biological information measuring device 10, thereby starting the measurement of the respiratory arrest period and the LFCT measurement without detecting the respiratory state of the subject. Then, the biological information measuring device 10A for measuring the cardiac output of the subject will be described.

FIG. 10 is a diagram showing a configuration example of the biological information measuring device 10A. The configuration example of the biological information measuring device 10A shown in FIG. 10 differs from the configuration example of the biological information measuring device 10 shown in FIG. , the timer 15 and the reception unit 13A are connected.

Upon receiving the instruction to measure the cardiac output, the reception unit 13A notifies the notification unit 16A of start of measurement of the cardiac output. Further, the reception unit 13A receives the timer value measured by the timer 15 and notifies the notification unit 16A, and when the timer value reaches the specified time, notifies the notification unit 16A of the start of measurement of the oxygen circulation time. . That is, the timer value received by the receiving unit 13A from the timer 15 functions as an instruction to start measuring the oxygen circulation time.

Upon receiving the instruction to measure the cardiac output, the notification unit 16A notifies the user of the stoppage of breathing according to a predetermined rule and activates the timer 15. When the timer value reaches the specified time, oxygen circulation is started from the reception unit 13A. When the start of time measurement is notified, the measurement subject is notified of the resumption of breathing, and the oxygen circulation time measuring unit 17 is also notified that the measurement subject has resumed breathing.

Here, the "predetermined rule" refers to the notification timing of the notification of the stop of breathing, for example, the notification of the stop of breathing is notified after n seconds (n is an integer equal to or greater than 0) after receiving the instruction to measure the cardiac output. It is a set rule. Note that the value of n seconds that determines the notification timing of the breath stop notification is called "waiting time" and is a value that is changed by the user of the biological information measuring device 10A.

The oxygen circulation time measurement unit 17 starts measuring LFCT when receiving from the notification unit 16A that the subject's breathing has resumed, and the cardiac output measurement unit 18 detects the cardiac output of the subject. measured.

10 A of biological information measuring apparatuses mentioned above are comprised using a computer like the biological information measuring apparatus 10 which concerns on 1st Embodiment. In this case, an example configuration of the main part of the electrical system in the biological information measuring device 10A is the same as the example of the configuration of the main part of the electrical system in the biological information measuring device 10 shown in FIG.

Next, the operation of the biological information measuring device 10A will be described with reference to FIG.

FIG. 11 is a flow chart showing an example of the flow of biological information measurement processing executed by the CPU 21 when the biological information measurement device 10A is activated.

A photoelectric sensor 11 is attached to the fingertip of the person to be measured, and when the biological information measuring device 10A receives an instruction to measure the cardiac output, the oxygen saturation of the person to be measured is measured at least until the measurement of the cardiac output is completed. shall continue to measure. Also, it is assumed that the waiting time in the biological information measuring device 10A is set in advance to n seconds.

A biological information measurement program that defines the biological information measurement process is pre-stored, for example, in the ROM 22 of the biological information measurement device 10A. The CPU 21 of the biological information measurement device 10A reads the biological information measurement program stored in the ROM 22 and executes the biological information measurement process.

The flowchart of the biological information measurement process shown in FIG. 11 differs from the flowchart of the biological information measurement process according to the first embodiment shown in FIG. The only difference is that step S50 for accepting the resumption of breathing is deleted, and steps S2 to S8, S15, and S25 are added.

First, in step S2, the CPU 21 determines whether or not an instruction to measure cardiac output has been received from the user of the biological information measuring device 10A via the input unit 27 or not.

If it is determined that the cardiac output measurement instruction has not been received, the process of step S2 is repeatedly executed to monitor instructions from the user. On the other hand, when it is determined that the instruction to measure the cardiac output has been received, the process proceeds to step S4.

In step S4, the CPU 21 activates the timer 15 to start measuring the standby time.

In step S6, the CPU 21 determines whether or not the timer value of the timer 15 has reached the waiting time.

When the timer value of the timer 15 has not reached the standby time, the process proceeds to step S8, and in step S8, the CPU 21 notifies the subject of the remaining time until the standby time ends. The method of notifying the subject of the remaining time until the waiting time ends is not limited. is displayed on the display unit 28 . When a speaker unit is connected to the biological information measuring device 10A, the subject is notified by voice of the remaining time until the standby time ends. In addition, when a vibrating unit is connected to the biological information measuring device 10A, the vibrating unit is vibrated, and the subject is notified of the remaining time until the standby time ends through the subject's bodily sensation.

Then, the process proceeds to step S6, and the process of determining whether or not the timer value of the timer 15 has reached the waiting time is repeated.

On the other hand, when it is determined that the timer value of the timer 15 has reached the standby time in the determination process of step S6, the process proceeds to step S15.

When the standby time has elapsed after receiving the cardiac output measurement instruction, the CPU 21 stops the timer 15 in step S15 and notifies the person to be measured of the stoppage of breathing. As a result, the CPU 21 assumes that the person to be measured has stopped breathing, executes step S20 already described, activates the timer 15 again, and starts measuring the breathing stop period. In other words, the biological information measuring device 10A starts measuring the breathlessness period without confirming that the subject has stopped breathing.

Until it is determined in step S30 that the breathing stop period has reached the specified time, the CPU 21 measures the remaining time until the specified time expires in step S25 using the notification method described in step S8. notify the person.

Further, unlike the biological information measuring device 10, the CPU 21 executes step S60 without confirming that the subject's breathing has been resumed after notifying the respiration notification in step S40, and continues to perform the LFCT. start measuring.

Thereafter, steps S70 to S90 already described are executed by the CPU 21, and the cardiac output of the subject is measured. With the above, the biological information measurement process shown in FIG. 11 ends.

In steps S8 and S25, the remaining time until the end of the standby time and the remaining time until the end of the specified time are notified, respectively, but there is no limit to the method of expressing the remaining time. For example, if notification is given 10 seconds before the remaining time, the subject is notified of the remaining time in a countdown format, such as "10" → "9" → ... → "1" → "0". good too. In addition, for example, when notifying 10 seconds before the remaining time, the remaining time is counted up in the form of “0” → “1” → … → “9” → “10”. may notify you.

In addition, the content of various modifications regarding the biological information measuring process described in the first embodiment is also applied to the biological information measuring apparatus 10A.

For example, in the _biological information measurement process shown in _FIG . Alternatively, the timer 15 may be restarted at step S60 in FIG. ₁₁ instead of storing the time t1, and the timer 15 may be stopped at step S80 instead of storing the _time t2 at which the inflection point appears. In this case, the accumulated time measured by the timer 15 from when the subject is notified of the resumption of breathing to when the inflection point of the oxygen saturation appears may be acquired as the LFCT.

In addition, even if the subject is notified of the resumption of breathing notification from the biological information measuring device 10A, the subject will resume breathing after recognizing that the notification of the resumption of breathing has been notified. It is conceivable that a delay time may occur from when the device 10A notifies of the resumption notification to when breathing is actually resumed.

Therefore, the biological information measuring apparatus 10A may measure the LFCT in consideration of the delay time from when the notification of resumption of breathing is given until the subject actually resumes breathing.

Specifically, the CPU 21 may acquire the time obtained by subtracting the delay time from the LFCT acquired in step S80 of FIG. 11 as the final LFCT.

Moreover, as already explained, the biological information measuring device 10A does not necessarily need to perform real-time processing of measuring the subject's cardiac output while measuring the oxygen saturation.

For example, the CPU 21 stores in the RAM 23 the oxygen saturation and the time information for each time in a predetermined period after at least the timer value of the timer 15 reaches the specified time, and executes the processing of steps S70 to S90. Without doing so, the biological information measurement process shown in FIG. 11 is once terminated.

When the CPU 21 receives a cardiac output measurement instruction from the user of the biological information measuring device 10A, the CPU 21 reads from the RAM 23 the oxygen saturation and time information at each time after the timer value of the timer 15 reaches the specified time. . After that, the CPU 21 executes the processing of steps S70 to S90 in FIG. 11, detects the inflection point of the oxygen saturation from the read oxygen saturation change, and detects the time when the timer value of the timer 15 reaches the specified time. That is, the LFCT is obtained from the difference between the time t ₁ when the subject resumes breathing and the time t ₂ when the oxygen saturation inflection point appears, and the cardiac output is measured using the obtained LFCT.

Note that the biological information measuring apparatus 10A starts LFCT measurement after notifying the respiration resumption notification without confirming respiration resumption of the subject. Therefore, among the various modifications of the biological information measurement process described in the first embodiment, whether or not the period from when the notification of resuming breathing to when the subject's respiration actually resumes is within the allowable delay period. If the period exceeds the allowable delay period, the modified example of terminating the biological information measurement process without measuring the LFCT is not applied to the biological information measurement apparatus 10A.

As described above, according to the biological information measuring device 10A according to the second embodiment, an instruction to notify of stopping and resuming breathing is received according to the timer value of the timer 15 . Then, when the biological information measuring device 10A receives an instruction to notify the resumption of breathing, the biological information measuring apparatus 10A measures the time from the reception of the instruction to the appearance of the inflection point of the oxygen saturation, and measures the oxygen circulation time and the cardiac output. Measure quantity. Therefore, also in the biological information measuring apparatus 10A, the oxygen circulation time and cardiac output of the subject are measured without using detection means such as an airflow sensor for detecting the subject's respiratory condition.

Although the present invention has been described above using each embodiment, the present invention is not limited to the scope described in each embodiment. Various modifications or improvements can be made to each embodiment without departing from the gist of the present invention, and the modified or improved forms are also included in the technical scope of the present invention. For example, the order of processing may be changed without departing from the gist of the present invention.

Further, in each embodiment, as an example, a form in which the biological information measurement processing is realized by software has been described, but processing equivalent to the flowcharts shown in FIG. 9 and FIG. It may be implemented and processed by hardware. In this case, the biological information measurement process can be speeded up.

Moreover, although each embodiment mentioned above demonstrated the form installed in ROM22 with the biometric information measurement program, it is not limited to this. The biological information measurement program according to the present invention can also be provided in a form recorded on a computer-readable storage medium. For example, the biological information measurement program according to the present invention may be provided in a form recorded on an optical disc such as CD (Compact Disc)-ROM or DVD (Digital Versatile Disc)-ROM. Also, the biological information measurement program according to the present invention may be provided in a form recorded in a semiconductor memory such as a USB memory or a flash memory. Furthermore, the biological information measuring apparatuses 10 and 10A may acquire the biological information measuring program according to the present invention from an external device connected to the communication line via the communication unit 29. FIG.

Reference Signs List 1 (1A, 1B) Light-emitting element 3 Light-receiving element 4 Artery 5 Vein 6 Capillary vessel 8 Living body 10 (10A) Biological information measuring device 11 Photoelectric sensor 12 Pulse wave processing unit 13 Reception unit 14 Oxygen saturation measurement unit 15 Timer 16 (16A) Notification unit 17 Oxygen circulation time measurement Unit 18 Cardiac output measurement unit 20 Computer 21 CPU
22 ROM
23 RAM
24 Non-volatile memory 27 Input unit 28 Display unit 29 Communication unit 98 Red area 99 Infrared area

Claims (14)

Promoting means for prompting the person to be measured to resume breathing when the time measured by the measuring device reaches a specified time;
notification means for notifying that the breathing of the subject has resumed;
A measurement of measuring the oxygen circulation time from the time when the person to be measured resumes breathing to the appearance of an inflection point at which the change in blood oxygen concentration at a predetermined site of the person to be measured changes from decreasing to increasing. means and
with
The specified time is adjusted based on the age, gender, and physical condition information of the person to be measured.
Biological information measuring device. When the notifying means receives an instruction to notify the subject of resuming breathing from an input device operated by the subject or a subject who measures the biological information of the subject. , notifying that the breathing of the subject has resumed
The biological information measuring device according to claim 1. The notification means notifies that the subject's breathing has resumed when the time measured by the measuring device reaches the specified time representing a period of stoppage of breathing.
The biological information measuring device according to claim 1. The measuring means starts measuring time when an instruction to notify the subject of resuming breathing is received from the input device, and measures the blood oxygen concentration of the subject during the time measurement. When the point of inflection appears, the oxygen circulation time is measured using the cumulative time from when the input device receives an instruction to notify the person to resume breathing to when the point of inflection appears. The biological information measuring device according to claim 2 . The measuring means starts measuring time when the time measured by the measuring device reaches the specified time, and the inflection point of the blood oxygen concentration of the person to be measured appears during the time measurement. 4. The biological information measuring device according to claim 3 , wherein, in the case where the oxygen circulation time is measured, the oxygen circulation time is measured by using the cumulative time from when the measurement time of the measuring device reaches the specified time to when the inflection point appears. 6. The biological information measuring device according to claim 4, wherein said measuring means measures a time obtained by subtracting a predetermined time from said accumulated time as said oxygen circulation time. The measuring means acquires the time at which it is accepted that the respiration of the person to be measured has resumed from the notification means, and the time between the acquired time at which the respiration is accepted and the appearance time of the inflection point. The biological information measuring device according to claim 2 or 3, wherein the oxygen circulation time is measured using the difference. The measurement means detects the inflection point from the change in the blood oxygen concentration of the person to be measured, and determines the time when the inflection point is detected as the appearance time of the inflection point, and the oxygen circulation time. The biological information measuring device according to claim 7 , which measures. The measurement means stores the oxygen concentration for each hour in a storage device over a predetermined period, and the time corresponding to the inflection point obtained from the oxygen concentration for each hour stored in the storage device is the variation. The biological information measuring device according to claim 7 , wherein the oxygen circulation time is measured as the appearance time of the curved point. 8. The measuring means measures the time obtained by subtracting a predetermined time from the difference between the time when it is accepted that the respiration of the subject has resumed and the appearance time of the inflection point, as the oxygen circulation time. The biological information measuring device according to any one of claims 9 to 9. 10. The measuring means obtains the inflection point using oxygen saturation indicating the blood oxygen concentration of the subject, and measures the oxygen circulation time. 2. The biological information measuring device according to 1. 12. The biological information measuring device according to claim 11 , wherein the measurement means obtains the inflection point using oxygen saturation indicating blood oxygen concentration in the finger of the person to be measured, and measures the oxygen circulation time. an input device that receives an operation of the person to be measured or a measurer who measures the biological information of the person to be measured;
The biological information measuring device according to any one of claims 1 to 12, further comprising a display device for displaying that the specified time has been reached. A biological information measuring program for causing a computer to function as each means of the biological information measuring apparatus according to any one of claims 1 to 13.

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