JP7120660B2 - Blood sugar level increase inhibitor and antiflatulent agent - Google Patents

Description

TECHNICAL FIELD The present invention relates to a blood sugar elevation inhibitor and an intestinal regulator, and more particularly to a blood glucose elevation inhibitor and an intestinal regulator containing processed barley and a specific processed plant material as active ingredients.

Examples of products that pursue the function of processed barley include collagen absorption promoters containing young barley leaves (see Patent Document 1) and SOD (super-oxide dismutase) gene expression promoters containing young barley leaves as an active ingredient. agent (see Patent Document 2).

JP 2013-255512 A JP 2015-140338 A

An object of the present invention is to provide a blood sugar level increase suppressing agent containing a processed barley product and having a dramatically improved blood sugar level increase suppressing effect and an intestinal regulating agent having a significantly improved intestinal function.

Dietary fiber is believed to be effective in suppressing a rapid rise in blood sugar level after meals. The present inventors focused on plant materials rich in dietary fiber. First, young barley leaves, young rice leaves, young wheat leaves, and cabbage were selected as the main plant materials. As a result of investigating the effect of suppressing the value increase, the best effect was shown when young barley leaves were used.

Therefore, the present inventors conducted intensive investigations and studies on the effect of suppressing the increase in blood sugar level associated with the combination of young barley leaves and other plant materials. was found to be dramatically improved. In other words, there is almost no effect of suppressing elevation of blood sugar level, or even if there is such effect, by combining the plant material with the processed barley product, the effect of suppressing elevation of blood sugar level is greater than that of the processed barley product alone. I have found that it can be greatly improved. At the same time, by combining a plant material with little or no intestinal regulating action with the processed barley, the intestinal regulating action can be dramatically improved compared to the case of the processed barley alone. I found what I could do.

That is, the present invention provides a processed barley product and at least one selected from the group consisting of terminalaria, hops, mulberry, chlorella, kale, chomeisou, sweet potato, turmeric, ginger, soybeans, salacia, gymnema, guava, and eucommia. and a processed plant material.

In addition, the present invention provides a processed barley product and at least one selected from the group consisting of terminalaria, hops, mulberry, chlorella, kale, chomeisou, sweet potato, turmeric, ginger, soybeans, salacia, gymnema, guava, and eucommia. and a processed plant material.

In addition, the present invention uses a processed barley product as an active ingredient, and is further selected from the group consisting of terminalaria, hops, mulberry, chlorella, kale, chomeisou, sweet potato, turmeric, ginger, soybean, salacia, gymnema, guava, and eucommia. The present invention relates to a blood sugar elevation inhibitor characterized by containing as an active ingredient a processed product of at least one kind of plant material.

In addition, the present invention uses a processed barley product as an active ingredient, and at least terminalia, hops, mulberry, chlorella, kale, chomeisou, sweet potato, turmeric, ginger, soybean, salacia, gymnema, guava, and eucommia. The present invention relates to an antiflatulent agent characterized by containing a processed product of one kind of plant material as an active ingredient.

Tablets, granules, powders, or capsules are preferable as the form of the blood sugar elevation inhibitor and the antiflatulent agent.

According to the agent for suppressing elevation of blood sugar level of the present invention, the effect of suppressing elevation of blood sugar level can be dramatically improved as compared with the case of processed barley alone. Moreover, according to the antiflatulent agent of the present invention, the antiflatulent action can be dramatically improved as compared with the treatment of barley alone.

FIG. 2 is a diagram showing measurement results (variation values) of blood glucose levels in male KK-Ay mice to which the agent for suppressing elevation of blood glucose level of the present invention was applied. Fig. 2 is a diagram showing the results of measuring the number of feces in 24 hours in male KK-Ay mice to which the antiflatulent agent of the present invention was applied. FIG. 2 is a diagram showing the measurement results (change value) of body weight of male KK-Ay mice to which the agent of the present invention was applied.

The blood sugar level elevation inhibitor and antiflatulent agent of the present invention are selected from the group consisting of processed barley, terminalia, hops, mulberry, chlorella, kale, long life grass, sweet potato, turmeric, ginger, soybean, salacia, gymnema, guava, and eucommia. and a processed product of at least one selected plant material (hereinafter sometimes referred to as secondary material). The auxiliary material may be used singly or in combination of two or more.

The processed barley and processed plant material used for the blood sugar level elevation inhibitor and antiflatulent agent of the present invention may be any part of a plant such as leaves, stems, roots, flowers, fruits, trunks, branches, etc. A processed plant material such as pulverized plant material, squeezed juice, or extract can be used. Powders, granules and the like can be mentioned as pulverized products. The squeezed juice or extract may be liquid, but may also be used as paste or dried powder. An extract can be obtained by extraction using a suitable solvent, and may be heated if necessary. As the extraction solvent, for example, a water-soluble solvent such as water, ethanol, or water-containing ethanol can be used. Commercially available products can be used as the processed barley and the processed secondary materials.

[Processed barley]
As barley, two-rowed barley, six-rowed barley, etc. can be used. The parts used in the present invention are preferably stems and leaves, and particularly preferably young leaves.

[Secondary material]
(Terminalia)
Examples of Terminalia include Terminalia bellirica (belerica), Terminalia catappa, Terminalia tomentosa, Terminalia citrina, Terminalia phellocarpa, Terminalia copelandii, Terminalia brassi, Terminalia ivorensis, Terminalia superba, Terminalia arjuna, and Terminalia chebula. Among them, Terminalia bellirica (belerica) and Terminalia chebula are preferable. The part used in the present invention is preferably the fruit excluding the seed, and most preferably the peel or pulp of the fruit excluding the seed.
(hop)
Hop is a perennial climbing plant of the cannabaceae family. The site used in the present invention is preferably vines and leaves.

(hoe)
Mulberry is a plant belonging to the genus Mulberry of the family Moraceae. The parts used in the present invention are preferably stems and leaves, and particularly preferably leaves.
(chlorella)
Chlorella is a freshwater unicellular green algae of the genus Chlorella. As the chlorella used in the present invention, whole chlorella algae obtained by culturing by a conventional method can be used, and this culture solution or concentrates or dry powders of whole chlorella algae can be used.

(Kale)
Kale is a cruciferous plant, and leaves and stems are preferred as the parts used in the present invention. The variety of kale is not particularly limited, and various kinds of kale such as kitchen kale, tree kale, bush kale, mallow kale, collard greens, and green leaf kale can be used.
(Chomeisou)
Chomeisou is a perennial herb plant that belongs to the genus Apiaceae of the family Apiaceae and is also called Botanbofu. The parts used in the present invention are preferably stems and leaves.

(sweet potato)
Sweet potato refers to a plant belonging to the convolvulaceae family, and is generally called sweet potato. The variety of sweet potato is not particularly limited, and examples thereof include Suiou, Joy White, Kogane Sengan, Shiroyutaka, Satsuma masterchi, and Ayamurasaki. The parts used in the present invention are preferably stems and leaves, and particularly preferably young leaves.
(turmeric)
Turmeric is a perennial plant of the genus Curcuma belonging to the family Zingiberaceae, and has long been used as a dye and fragrance. Types of turmeric include, for example, spring turmeric (Kyouou), autumn turmeric, purple turmeric (Zedota), etc. Autumn turmeric is particularly preferred. A rhizome is preferable as the part used in the present invention.

(Ginger)
Ginger is a plant belonging to the Zingiberaceae family Zingiber genus, and examples thereof include Sanshu ginger, yellow ginger, Kintoki ginger, and Yanaka ginger. A rhizome is preferable as the part used in the present invention.
(soy)
A soybean is an annual plant belonging to the genus Soybean of the legume family, and examples thereof include black soybeans, red soybeans, green soybeans, white soybeans, and black soybeans. The site used in the present invention is preferably a seed. Also, soybeans may be processed products, and soybean flour is particularly preferred.

(Salacia)
Salacia is a plant belonging to the genus Salacia of the family Euonymus, which grows mainly in Sri Lanka, India, and Southeast Asia. is particularly preferred. Roots are preferred as the site used in the present invention.

(gymnema)
Gymnema is a climbing plant belonging to the family Apocynaceae, whose production is reduced in India and Sri Lanka. For example, Gymnema sylvestre can be mentioned. The parts used in the present invention are preferably stems and leaves.
(guava)
Guava is a plant belonging to the genus Myrtaceae, and includes, for example, Psidium guajava L. can be mentioned. The parts used in the present invention are preferably stems and leaves.

(Tochu)
Eucommia ulmoides is a deciduous tall tree native to China, and the parts used in the present invention are preferably stems and leaves, and particularly preferably eucommia leaves picked before defoliation.

[Other materials]
(pullulan)
Pullulan is a water-soluble polysaccharide in which maltotriose consisting of three glucose units with α-1,4 bonds are linked in a chain with repeating α-1,6 bonds. When this pullulan is added alone to the barley processed product, it exhibits the same effect as the above-mentioned auxiliary material. Pullulan can be blended with the processed barley alone or together with the above secondary ingredients. As a raw material for pullulan, fermented starch derived from corn, potato, sweet potato, or the like can be used. Filamentous fungi can be used for fermentation, and examples of filamentous fungi include Aureobasidium pullulans.

The mixing mass ratio of the processed barley product and the processed plant product is preferably in the range of 0.02:1 to 100:1, more preferably in the range of 0.05:1 to 50:1 in terms of dry mass. is more preferred, a range of 0.1:1 to 40:1 is more preferred, and a range of 0.5:1 to 30:1 is particularly preferred. By setting the mixing ratio of the processed barley product and the processed plant product within the above range, the effects of the present invention can be exhibited more effectively.

The content of the processed barley product and the processed plant product (active ingredient) in the blood sugar level elevation inhibitor and antiflatulent agent of the present invention may be appropriately contained within the range in which the effect is exhibited. In the blood sugar level elevation inhibitor, it is preferable that the active ingredient is contained in an amount of 0.01 to 100% by mass, more preferably 0.1 to 85% by mass, in terms of dry mass. It is more preferable that the content is 0.5 to 70% by mass.

The agent for suppressing elevation of blood sugar level and the antiflatulent agent of the present invention can be used as an oral preparation, and the intake amount is not particularly limited. The intake amount is preferably 500 mg/day or more, more preferably 1000 mg/day or more, and even more preferably 1500 mg/day or more. The blood sugar elevation inhibitor and antiflatulent agent of the present invention are contained in one container or divided into a plurality of containers such as 2 to 3 so that the daily intake is the above-mentioned intake as a daily supply. be able to.

In particular, the agent for suppressing elevation of blood sugar level of the present invention should be taken so that the daily intake as dietary fiber amount is 600 mg/day or more from the viewpoint of exhibiting the effect of the present invention more remarkably. is preferred, more preferably 1200 g/day or more, and even more preferably 1800 g/day or more. The blood sugar level elevation inhibitor of the present invention can be contained in one container or divided into a plurality of containers, for example, 2 to 3, so that the daily intake is the above-mentioned intake. can.

In addition, in particular, in the intestinal regulator of the present invention, from the viewpoint of exhibiting the effects of the present invention more remarkably, it is preferable to ingest the amount of dietary fiber per day so as to be 650 mg/day or more, and 1300 g. /day or more, more preferably 1950 mg/day or more. The antiflatulent agent of the present invention can be contained in one container, or divided into a plurality of containers, for example, 2 to 3, so that the daily intake is equal to the above-mentioned intake for one day.

The blood sugar elevation inhibitor and antiflatulent agent of the present invention contain a processed barley product and a prescribed plant treated product, and can be distinguished from other products as a product in that they are used for suppressing the elevation of blood sugar levels or regulating the intestines. For example, a drug labeled as having the function of suppressing blood sugar level elevation and/or intestinal regulation in any of the main body, packaging, instructions, and advertising materials of the product according to the present invention. are within the scope of the present invention.

The blood sugar elevation inhibitor and antiflatulent agent of the present invention can be produced by a known formulation method by adding orally acceptable excipients and the like, if necessary. Examples of excipients include calcium stearate, silicon dioxide, sucrose fatty acid ester, glycerin fatty acid ester, maltose, reduced maltose, reduced palatinose, cellulose, and hydroxypropylcellulose.

Examples of the forms of the blood sugar elevation inhibitor and intestinal agent of the present invention include tablets, granules, powders, capsules, liquids, granules, rods, plates, blocks, solids, and rounds. agents, pastes, creams, caplets, gels, chewables, sticks and the like. Among these, tablets, granules, powders, capsules, and liquid formulations are particularly preferred.

In addition, the blood glucose level elevation inhibitor and antiflatulent agent of the present invention may contain ingredients other than the processed barley and the prescribed processed plant, if necessary. Examples of components other than processed barley products and predetermined processed plant products include water-soluble vitamins (vitamin B1, B2, B3, B5, B6, B12, B13, B15, B17, biotin, choline, folic acid, inositol, PABA, vitamins such as vitamin C, vitamin P) and oil-soluble vitamins (vitamins A, D, E, K); minerals such as calcium, magnesium, phosphorus, and iron; taurine, sulfur-containing compounds contained in garlic, etc.; hesperidin, Flavanoids such as quercetin or flavonoids; proteins such as collagen; peptides; amino acids;

EXAMPLES The present invention will be described below based on examples.
[Example 1]
Male KK-Ay mice aged 8 to 19 weeks (model mice that spontaneously develop type 2 diabetes and develop obesity and hyperglycemia) are subjected to an acclimation period or a rest period, after which blood glucose and body weight levels become uniform. grouped as follows. Each test group was allowed to ingest the test feed shown in Table 1 ad libitum for 4 days.

For barley, the dry ground powder of young leaves was used.
For hops, dry ground powder of leaves and vines was used.
For mulberry, the dry crushed powder of stems and leaves was used.
As for chlorella, commercially available chlorella micropowder was used.
For kale, dry ground powder of leaves was used.
As for Chomeisou, dried crushed powder of stems and leaves was used.
For the sweet potato, dry ground powder of young leaves was used.
For Terminalia, dry ground powder of aqueous extracts of fruits and pericarp of Terminalia berylica was used.
As for turmeric, dried and pulverized rhizomes of autumn turmeric were used.
For ginger, the dry ground powder of the rhizome was used.
Commercially available soybean flour was used for soybeans.
For Salacia, a dry powder of hydrous ethanolic extract of Salacia reticula root was used.
For Gymnema, a dry powder of hydrous ethanolic extract of leaves of Gymnema sylvestre was used.
For guava, a guava polyphenol concentrate (powder) extracted from leaves with hydrous ethanol was used.
For Eucommia communis, dry powder of hot water extract of leaves was used.

Each test group was subjected to a blood sugar level measurement test, an intestinal regulation effect confirmation test, and a body weight measurement test. Specifically, it is as follows.

(Blood glucose level measurement test)
At the time of grouping (the 0th day of the test) and on the 3rd day of the test, blood was collected from the tail vein after about 1 hour of fasting, and the blood sugar level (mg/dL) was measured. A compact blood glucose meter (Glutest Ace; Sanwa Kagaku Kenkyusho Co., Ltd.) was used for the measurement.

FIG. 1 shows measurement results (variation values) of blood glucose levels. In contrast to the blood glucose level of the control with only the standard feed and the standard feed with barley or each supplementary material alone, in the examples of the present invention in which barley and supplementary materials were blended, the blood sugar level was reduced in all cases. A decrease was observed, confirming the synergistic effect of barley and each sub-material.

(Confirmation test for intestinal regulation effect)
On day 4 of the test, feces for 24 hours before measurement were collected, and the number of feces for 24 hours was measured.

FIG. 2 shows the measurement results of the number of stools. Compared to the control with only the standard feed and the number of stools in the feed containing barley or each submaterial alone in the standard feed, the number of stools in the examples of the present invention containing barley and submaterials was clearly observed. A synergistic intestinal regulation effect of barley and each auxiliary material was confirmed.

(Weight measurement test)
Body weight was measured by an electronic balance at the time of grouping (test day 0) and on test day 4.

FIG. 3 shows the measurement results (variation values) of body weight. In the examples of the present invention, in which barley and auxiliary materials were blended, compared to the control with only the standard feed and the rate of weight gain in the diets in which the standard diet was blended with barley and each secondary material alone, The percentage of weight gain was small, confirming the synergistic effect of barley and each auxiliary material.

[Reference example]
A test was conducted in the same manner as in Example 1 using pullulan in place of the auxiliary material. As a result, in the blood glucose measurement, the amount of change was about +210 mg/dL with the feed containing pullulan alone, but with the feed containing barley and pullulan, it decreased significantly to about -145 mg/dL. and a synergistic effect of pullulan was confirmed. In addition, in the confirmation of the intestinal regulation effect, the feed containing pullulan alone had 61, whereas the feed containing barley and pullulan had 95, confirming the synergistic effect of barley and pullulan. Furthermore, in body weight measurement, the amount of change was about +1.3 g for the feed containing pullulan alone, but it was about +0.2 g for the feed containing barley and pullulan, confirming the synergistic effect of barley and pullulan. .

[Example 2] (Production of tablets)
Each component was mixed in the ratio shown below, and tableted with a tableting machine.

Ingredient Composition (mg)
Barley grass powder 135
Hop leaf end 15
Dextrin 120
vitamins 15
Anhydrous citric acid 15

By ingesting about 4 to 10 tablets per day (600 to 1500 mg of the active ingredient per day), it is expected that an effect of suppressing elevation of blood sugar level and/or an effect of regulating intestinal function can be obtained.

[Example 3] (Production of capsules)
One part by weight of chlorella powder was mixed with 15 parts by weight of green barley powder to prepare granules according to a conventional method, and 300 mg of the granules were filled into capsules to prepare capsules.

By ingesting 6 capsules per day (1800 mg of active ingredient per day), it is expected that an effect of suppressing elevation of blood sugar level and/or an effect of regulating intestinal function can be obtained.

[Example 4] (Production of granules)
15 parts by weight of processed barley was mixed with 1 part by weight of ginger powder to prepare granules according to a conventional method, and 1.8 g of the granules were packed in an aluminum stick.

By ingesting 3 bags of the present granules per day (5400 mg of active ingredient per day), it is expected that an effect of suppressing elevation of blood sugar level and/or an effect of regulating intestinal function can be obtained.

INDUSTRIAL APPLICABILITY The agent for suppressing elevation of blood sugar level and the agent for regulating the intestinal level of the present invention have the effect of suppressing elevation of blood glucose level or the effect of regulating intestinal function, and can be used as an oral preparation, and thus are highly industrially useful.

Claims (2)

A composition for suppressing an increase in blood sugar level, characterized by containing a processed barley product and a processed product of Eucommia communis (however, green juice containing black oolong tea, young sweet potato leaves, kale, ginseng, turmeric, Houttuynia cordata, licorice , garlic, eleuthero, guava leaf, mulberry leaf, panax ginseng, rice germ, water-soluble dietary fiber, brewer's yeast, oligosaccharide, and soybean flour.) A composition for intestinal regulation characterized by containing a processed barley product and a processed product of Eucommia communis (however, green juice containing black oolong tea, young sweet potato leaves, kale, ginseng, turmeric, houttuynia cordata, licorice, garlic , eleuthero, guava leaves, mulberry leaves, ginseng, rice germ, water-soluble dietary fiber, brewer's yeast, oligosaccharides and soybean flour.)

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