JP7199832B2 - Oxidative hair dye or hair bleaching agent, oxidative hair dyeing kit or hair bleaching kit, oxidative hair dyeing method or hair bleaching method - Google Patents

Description

The present invention relates to an oxidative hair dye or hair bleaching agent to be applied to hair, an oxidative hair dyeing agent kit or hair bleaching agent kit, and an oxidative hair dyeing method or hair bleaching method.

In the oxidation hair dyeing method using an oxidation hair dye containing an oxidation dye, an alkali agent and an oxidizing agent, and the hair bleaching method using a hair bleaching agent containing an alkali agent and an oxidizing agent. is difficult to avoid contacting the composition to the skin, such as the scalp, forehead, and nape of the neck. Since stimulation may be felt after this contact, proposals for stimulation suppression are disclosed in Patent Documents 1 to 3 and the like. Patent Document 1 discloses the inclusion of a plant extract with anti-inflammatory and irritation-relieving effects and honey, Patent Document 2 discloses the blending of phytic acid or a salt thereof, and Patent Document 3 discloses , which contains a Saccharomyces yeast extract.

JP 2015-3881 A JP-A-2007-39351 JP-A-2006-98438

By the way, it is known that irritation of the skin such as the scalp is caused by allergic contact dermatitis and primary irritant dermatitis. The latter dermatitis is caused by stimulation of skin cells, and the intensity of stimulation is said to be related to the condition of the skin and the degree of dermatitis. Oxidative hair dyes and hair bleaching agents, which contain an alkaline agent such as ammonia and an oxidizing agent such as hydrogen peroxide, are likely to irritate skin cells and cause primary irritant dermatitis. It is said that the stimulation can also be confirmed by a test using a three-dimensional cultured skin model.

In view of the above circumstances, the present invention provides an oxidative hair dye or hair bleaching agent that can be expected to suppress irritation to the skin such as the scalp, with good results obtained in tests using a three-dimensional cultured skin model, and the composition. The purpose of the present invention is to provide an oxidative hair dyeing kit or a hair bleaching kit for obtaining the above, and an oxidative hair dyeing method or hair bleaching method using the composition.

As a result of diligent studies using a three-dimensional cultured skin model that can be expected to evaluate the suppression of skin irritation, the inventors of the present invention found that an oxidative hair dye or hair bleaching agent containing an alkaline agent and an oxidizing agent contains two predetermined components. The present inventors have found that the results of the study are excellent if they are also blended, leading to the completion of the present invention.

That is, the oxidative hair dye or hair bleaching agent according to the present invention is characterized by containing the following components (A), (B), (C) and (D).
(A) alkaline agent (B) oxidizing agent (C) N-acylaminoethyl-N-2-hydroxyethylglycine, N-acylaminoethyl-N-2-hydroxyethylglycinate, N-acylaminoethyl-N- One or more selected from 2-hydroxyethylpropionic acid and N-acylaminoethyl-N-2-hydroxyethylpropionate (D) Meadowfoam oil, persic oil, olive oil and vegetable squalane derived from olive oil One or two or more selected from

The oxidative hair dye kit or hair bleaching kit according to the present invention is for obtaining the oxidative hair dye or hair bleaching agent according to the present invention, and comprises the component (A) and the component ( A first agent containing C) and/or the component (D), and a second agent containing the component (B) and the component (C) and/or the component (D). , is provided.

Further, the oxidative hair dyeing method or hair bleaching method according to the present invention is the oxidative hair dyeing agent or hair bleaching agent according to the present invention, in which the above components (A), (B), (C) and (D) are blended. is characterized by using

According to the oxidative hair dye or hair bleaching agent of the present invention, N-acylaminoethyl-N-2-hydroxyethylglycine, N-acylaminoethyl-N-2-hydroxyethylglycine salt, N-acylaminoethyl - One or more selected from N-2-hydroxyethylpropionic acid and N-acylaminoethyl-N-2-hydroxyethylpropionate, and meadowfoam oil, persic oil, olive oil and olive oil-derived plant Since one or two or more selected from squalene is blended, good results are obtained in tests using a three-dimensional cultured skin model, and irritation to the skin that tends to occur due to the blending of alkaline agents and oxidizing agents is prevented. Suppression can be expected.

According to the oxidative hair dye kit or hair bleaching kit according to the present invention, the oxidative hair dye kit or hair bleaching kit according to the present invention can be obtained by mixing the first agent and the second agent at the time of use. Since an agent kit can be obtained, good results can be obtained in tests using a three-dimensional cultured skin model, and it can be expected to suppress irritation to the skin that tends to occur due to the combination of an alkaline agent and an oxidizing agent.

Further, according to the oxidation hair dyeing method or hair bleaching method of the present invention, N-acylaminoethyl-N-2-hydroxyethylglycine, N-acylaminoethyl-N-2-hydroxyethylglycine salt, N-acyl One or more selected from aminoethyl-N-2-hydroxyethylpropionic acid and N-acylaminoethyl-N-2-hydroxyethylpropionate, meadowfoam oil, persic oil, olive oil and olive oil-derived Since an oxidative hair dye or hair bleaching agent containing one or more selected from vegetable squalane is used, good results are obtained in tests using a three-dimensional cultured skin model, and alkali It can be expected to suppress irritation to the skin that tends to occur due to the combination of the agent and the oxidizing agent.

The present invention will be described below based on the embodiments of the present invention.
(Oxidative hair dye)
The oxidative hair dye of the present embodiment is the first agent in an oxidative hair dye kit comprising a first agent containing the following component (A) and a second agent containing the following component (B). It can be obtained by mixing the second agent (a typical oxidative hair dye of the present embodiment contains 70% by mass or more of water). The oxidative hair dye of the present embodiment contains the following components (C) and (D).
(A) alkaline agent (B) oxidizing agent (C) N-acylaminoethyl-N-2-hydroxyethylglycine, N-acylaminoethyl-N-2-hydroxyethylglycinate, N-acylaminoethyl-N- One or more selected from 2-hydroxyethylpropionic acid and N-acylaminoethyl-N-2-hydroxyethylpropionate (D) Meadowfoam oil, persic oil, olive oil and vegetable squalane derived from olive oil One or two or more selected from

The oxidative hair dye of the present embodiment becomes alkaline by blending the component (A), which is an alkaline agent. The amount of component (A) in the oxidative hair dye of the present embodiment is such that the pH of the composition at 25° C. is, for example, 8.5 or more and 12.0 or less, and 9.0 or more and 11.0. The amount of 9.5 or more and 10.5 or less is preferable. An amount that provides a pH of 8.0 or more is suitable for good hair dyeing properties, and an amount that provides a pH of 12.0 or less is suitable for suppressing irritation to the skin.

The component (B), an oxidizing agent, is blended to exhibit hair bleaching and oxidative hair dyeing effects. The blending concentration of the oxidizing agent in the oxidative hair dye of the present embodiment is, for example, 1% by mass or more and 4% by mass or less.

N-acylaminoethyl-N-2-hydroxyethylglycine, N-acylaminoethyl-N-2-hydroxyethylglycine salt, N-acylaminoethyl-N-2-hydroxyethylpropionic acid and By adding one or more selected from N-acylaminoethyl-N-2-hydroxyethylpropionate to the oxidative hair dye of the present embodiment, test results using a three-dimensional cultured skin model are obtained. become good.

［上記一般式（１）において、Ｒ^１は、炭化水素基を表し、例えば炭素数１０以上１８以下の飽和又は不飽和の炭化水素基である。］ N-acylaminoethyl-N-2-hydroxyethylglycine, which is the component (C), is represented by the following general formula (1). Examples of N-acylaminoethyl-N-2-hydroxyethylglycine and salts thereof include sodium cocoamphoacetate, sodium caproamphoacetate, sodium lauroamphoacetate, and stearamphoacetate.

[In the general formula (1), R ¹ represents a hydrocarbon group, for example, a saturated or unsaturated hydrocarbon group having 10 or more and 18 or less carbon atoms. ]

［上記一般式（２）において、Ｒ^２は、炭化水素基を表し、例えば炭素数１０以上１８以下の飽和又は不飽和の炭化水素基である。］ The component (C), N-acylaminoethyl-N-2-hydroxyethylpropionic acid, is represented by the following general formula (2). Examples of N-acylaminoethyl-N-2-hydroxyethylpropionic acid and salts thereof include Na cocoamphopropionate.

[In the general formula (2), R ² represents a hydrocarbon group, for example, a saturated or unsaturated hydrocarbon group having 10 or more and 18 or less carbon atoms. ]

The concentration of component (C) in the oxidative hair dye of the present embodiment is, for example, 0.01% by mass or more and 1.3% by mass or less, preferably 0.1% by mass or more and 1.5% by mass or less. .3% by mass or more and 2.5% by mass or less is preferable. When it is 0.01% by mass or more, test results using a three-dimensional cultured skin model are better, and when it is 10% by mass or less, it is suitable for suppressing the odor of ammonia, which is an alkaline agent.

By blending one or more selected from component (D) meadowfoam oil, persic oil, olive oil, and vegetable squalane derived from olive oil into the oxidative hair dye of the present embodiment, three-dimensional cultured skin can be obtained. Better test results using the model. Here, meadowfoam oil is the fatty oil obtained from the seeds of the meadowfoam (Limnanthes alba), persic oil is the fatty oil obtained from the kernels of the apricot (Prunus armeniaca), olive oil is the oil obtained from the olive (Olea europaea), and vegetable squalane derived from olive oil is obtained by hydrogenating squalene derived from olive oil. As component (D), vegetable squalane derived from meadowfoam oil, persic oil or olive oil is preferably blended, and meadowfoam oil is more preferably blended.

The concentration of component (D) in the oxidative hair dye of the present embodiment is, for example, 0.1% by mass or more and 4.0% by mass or less, preferably 0.5% by mass or more and 5.0% by mass or less. 0% by mass or more and 7.5% by mass or less is preferable. If it is 0.1% by mass or more, the test results using a three-dimensional cultured skin model will be better, and if it is 7.5% by mass or less, the hair after treatment with the oxidative hair dye will have an oily feel. suppressed.

The oxidative hair dye of the present embodiment contains an oxidative dye, like known oxidative hair dyes. The concentration of the oxidative dye in the oxidative hair dye is, for example, 0.03% by mass or more and 5% by mass or less.

The mixing ratio of the first agent and the second agent for obtaining the oxidation hair dye of the present embodiment is, for example, the mass of the first agent: the mass of the second agent=1:0.5 or more and 2 or less.

The dosage form of the oxidative hair dye according to the present embodiment is not particularly limited, and examples thereof include liquid, cream, wax, gel, and foam. The viscosity of the oxidative hair dye of the present embodiment is preferably cream-like in consideration of handling properties such as application to the hair and dripping during use.

The oxidative hair dye of the present embodiment is used by applying it to the hair in the same manner as known oxidative hair dyes.

First Agent The first agent for obtaining the oxidation hair dye of the present embodiment is a mixture of an alkaline agent as the component (A) and an oxidation dye (typical as the first agent of the present embodiment). and those containing 70% by mass or more of water). This first agent contains component (C), component (D), or components (C) and (D), depending on whether components (C) and/or (D) are added to the second agent. be done. Moreover, you may mix|blend with the 1st agent which concerns on this embodiment by using a well-known 1st agent raw material as an arbitrary raw material.

Examples of the alkali agent that is the component (A) include metal hydroxides such as sodium hydroxide and potassium hydroxide; metal carbonates such as sodium carbonate and potassium carbonate; metal phosphates such as sodium phosphate; aqueous ammonia; ammonium salts such as ammonium carbonate, ammonium bicarbonate and ammonium sulfate; alkanolamines such as monoethanolamine, triethanolamine and isopropanolamine;

The amount of component (A) in the first agent of the present embodiment is such that the pH of the first agent at 25° C. is, for example, 8.5 or more and 12.5 or less, and is 9.0 or more and 11.0. The amount of 9.5 or more and 10.5 or less is preferable. An amount that provides a pH of 8.5 or more is suitable for good hair dyeing properties, and an amount that provides a pH of 12.5 or less is suitable for suppressing irritation to the skin.

As the oxidation dye to be blended in the first agent, one or more selected from known dye intermediates that independently develop color by oxidation reaction are employed. Dye intermediates include phenylenediamine derivatives such as toluene-2,5-diamine sulfate, nitro-para-phenylenediamine hydrochloride and para-phenylenediamine; phenol derivatives such as 2,4-diaminophenol hydrochloride, ortho-aminophenol and para-aminophenol; is mentioned.

Further, as the oxidation dye of the first agent, one or more selected from known couplers that exhibit a color tone upon being oxidized by a dye intermediate may be employed. Examples of couplers include phenylenediamine derivatives such as 2,4-diaminophenoxyethanol hydrochloride and metaphenylenediamine hydrochloride; aminophenol derivatives such as 5-aminoorthocresol and metaaminophenol; resorcin;

The blending concentration of the oxidation dye in the first agent of the present embodiment is, for example, 0.05% by mass or more and 10% by mass or less.

When the component (C) is blended in the first agent of the present embodiment, the blending concentration is, for example, 0.02% by mass or more and 2.5% by mass or less, and 0.2% by mass or more and 3.0% by mass. The following is preferable, and 0.6% by mass or more and 5.0% by mass or less is preferable.

When the component (D) is blended in the first agent of the present embodiment, the blending concentration is, for example, 0.2% by mass or more and 8.0% by mass or less, and 1.0% by mass or more and 10% by mass or less. Well, 2.0% by mass or more and 15% by mass or less is preferable.

Examples of known first agent raw materials that are arbitrarily blended in the first agent of the present embodiment include higher alcohols, nonionic surfactants, cationic surfactants, polyhydric alcohols, hydrocarbons, fats and oils, anti-inflammatory agents, and antioxidants. agent, chelating agent.

When a higher alcohol is added to the first agent, examples of the higher alcohol include cetanol, isocetyl alcohol, cetostearyl alcohol, stearyl alcohol, isostearyl alcohol, behenyl alcohol, octyldodecanol, and myristyl alcohol. One or two or more types of higher alcohols may be blended in the first agent, and the blending concentration of the higher alcohols is appropriately set, but is, for example, 2% by mass or more and 20% by mass or less.

When a nonionic surfactant is blended in the first agent, the nonionic surfactant includes, for example, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester. , polyoxyethylene sorbitol tetra-fatty acid ester, glycerin fatty acid ester, sorbitan fatty acid ester, polyglycerin fatty acid ester, sucrose fatty acid ester. One or two or more nonionic surfactants are preferably blended in the first agent, and the blending concentration of the nonionic surfactants is, for example, 5% by mass or more and 15% by mass or less.

When a cationic surfactant is blended in the first agent, the cationic surfactant includes, for example, long-chain alkyltrimethylammonium salts, di-long-chain alkyldimethylammonium salts, quaternary ammonium salts such as monoalkyl ether-type quaternary ammonium salts. salt. One or two or more cationic surfactants may be blended in the first agent, and the blending concentration of the cationic surfactant is, for example, 0.5% by mass or more and 2% by mass or less.

The pH of the first agent of the present embodiment at 25°C is, for example, 8.5 or more and 12.5 or less, preferably 9.0 or more and 11.0 or less, and preferably 9.5 or more and 10.5 or less. A pH of 8.5 or higher is suitable for good hair dyeing properties, and a pH of 12.5 or lower is suitable for suppressing skin irritation.

Moreover, the dosage form of the first agent according to the present embodiment is not particularly limited, and is an O/W emulsion such as a liquid, cream, wax, or gel. The viscosity of the first agent in the case of a cream dosage form is, for example, 30000 mPa·s or more and 60000 mPa·s or less after 60 seconds measured at 25°C and 12 rpm using a Brookfield viscometer.

Second Agent The second agent for obtaining the oxidative hair dye of the present embodiment contains an oxidizing agent as the component (B) (a typical second agent of the present embodiment is The blending amount of water is 70% by mass or more.). This second agent contains component (C), component (D), or components (C) and (D), depending on whether components (C) and/or (D) are added to the first agent. be done. Moreover, you may mix|blend the 2nd agent which concerns on this embodiment as a well-known 2nd agent raw material as an arbitrary raw material.

Examples of the oxidizing agent that is the component (B) include hydrogen peroxide, bromate, percarbonate, and perborate. The blending concentration of the oxidizing agent in the second agent of the present embodiment is not particularly limited, but is, for example, 2% by mass or more and 7% by mass or less.

When the component (C) is blended in the second agent of the present embodiment, the blending concentration is, for example, 0.02% by mass or more and 2.5% by mass or less, and 0.2% by mass or more and 3.0% by mass. The following is preferable, and 0.6% by mass or more and 5.0% by mass or less is preferable.

When the component (D) is blended in the second agent of the present embodiment, the blending concentration is, for example, 0.2% by mass or more and 8.0% by mass or less, and 1.0% by mass or more and 10% by mass or less is Well, 2.0% by mass or more and 15% by mass or less is preferable.

Known materials for the second agent that are arbitrarily blended in the second agent of the present embodiment include higher alcohols (the blending concentration is, for example, 1% by mass or more and 6% by mass or less), nonionic surfactants (the blending concentration is, for example, 1% by mass). % or more and 5 mass % or less), cationic surfactants (the blending concentration is, for example, 0.1 mass % or more and 3 mass % or less), polyhydric alcohols, ester oils, antioxidants, chelating agents, and the like.

The dosage form of the second agent is not particularly limited, and examples thereof include liquid, cream, and gel. For example, it is 2.0 or more and 4.0 or less.

(Hair bleaching agent)
The hair bleaching agent of the present embodiment, like known hair bleaching agents, is used to oxidatively decompose melanin pigments in hair to lighten hair color. The hair bleaching agent of the present embodiment does not contain an oxidation dye for dyeing hair. The hair bleaching agent of the present embodiment does not differ from the oxidative hair dyeing agent of the present embodiment except that this oxidation dye is not blended.

EXAMPLES The present invention will be described in detail below based on examples, but the present invention is not limitedly interpreted based on the description of these examples.
The oxidative hair dyes of Examples 1a and 1b were produced, and these compositions were evaluated for inhibition of skin irritation. Details are as follows.

(Oxidative hair dyes of Examples 1a and 1b)
The first agent of Example 1a and the second agent of Example 1a below were mixed at a mass ratio of 1:1 to prepare the oxidative hair dye of Example 1a. Similarly, a mixture of the first agent of Example 1b and the second agent of Example 1b was used as the oxidative hair dye of Example 1b. The oxidative hair dyes of Examples 1a and 1b had a pH of 9.0 or more and 10.0 or less and had a cream-like dosage form.

First agents of Examples 1a and 1b The first agents of Examples 1a and 1b, which have a pH of 9.0 or more and 10.0 or less and a viscosity of 40000 mPa s or more and 50000 mPa s or less, were mixed with water. It was prepared by blending each component. Its ingredients are sodium cocoamphoacetate, meadowfoam oil, persic oil, oxidation dye, cetostearyl alcohol, polyoxyethylene alkyl ether, glyceryl monostearate, quaternary ammonium salt, PEG (20), dextrin, anti-inflammatory agent, isopropyl. Alcohol, antioxidant, chelating agent, ammonium bicarbonate, ammonia water, and perfume were added in the amounts shown in Table 1-1 below.

Second agents of Examples 1a and 1b Cream-like second agents of Examples 1a and 1b having a pH of 2.5 or more and 3.5 or less and a viscosity of 5000 mPa s or more and 10000 mPa s or less were mixed with water. It was prepared by blending each component. Its ingredients are cocamidopropyl betaine, hydrogen peroxide, cetostearyl alcohol, polyoxyethylene alkyl ether, quaternary ammonium salt, jojoba oil, meadowfoam oil, chelating agent and phenoxyethanol. 2.

(Suppression evaluation of skin irritation)
Using "EPISKIN" manufactured by Skin Ethic, the test was conducted according to the following conditions (1) to (5) according to the OECD Test Guideline 439. Suppression of skin irritation was evaluated using the cell survival index in (5) below.
(1) EPISKIN was precultured on a maintenance medium under conditions of 37° C. and 5% CO ₂ up to 24 hours before applying the oxidative hair dye.
(2) 200±15 mg of the oxidative hair dye was obtained by mixing the first part and the second part at a mass ratio of 1:1, and about 5 minutes later, it was applied to EPISKIN. After 60 minutes from the application, the oxidative hair dye was wiped off with a sterile cotton swab and thoroughly washed with phosphate-buffered saline (PBS(+): "DPBS, calcium, magnesium" manufactured by bibco). .
(3) 150 μL of PBS(+) was added to the EPISKIN after washing, and post-culture was performed for 18 hours on a fresh maintenance medium under conditions of 37° C. and 5% CO ₂ .
(4) EPISKIN after post-culture was transferred to an evaluation medium containing 10% resazurin ("Alamar Blue" manufactured by BIO-RAD) and cultured for 5 hours under conditions of 37°C and 5% _CO2 . rice field.
(5) The medium for evaluation was transferred to a 96-well plate, and the fluorescence at 590 nm when excited at 560 nm was measured as a cell survival index.

Table 1-3 below shows the evaluation results. In addition, "EPISKIN" manufactured by Skin Ethic Co., Ltd. used in "Evaluation of suppression of skin irritation" in Table 1-3 is of the same production lot, and the same "Evaluation of suppression of skin irritation" is performed on two subjects whose fluorescence was measured. Mean Cell Viability Index.

In Table 1-3, "Evaluation of suppression of skin irritation" is "cell survival index", so that the larger the value, the more cells survived and the better the evaluation result. It can be confirmed that Example 1a, which contains a larger amount of the component (B), was superior to Example 1b in the "evaluation of suppression of skin irritation." This indicates that when the amount of component (B) added increases the "skin irritation suppression evaluation", the evaluation is further improved.

Separately from the oxidative hair dyes of the above Examples, the oxidative hair dyes of Reference Examples 1a and 1b were produced and evaluated for inhibition of skin irritation in the same manner as in Example 1a. Details are as follows.

(Oxidative hair dyes of Reference Examples 1a to 1b)
A first agent of Reference Example 1a and a second agent of Reference Example 1a below were mixed at a mass ratio of 1:1 to obtain an oxidation hair dye of Reference Example 1a. Similarly, the oxidative hair dye of Reference Example 1b was obtained by mixing the first agent of Reference Example 1b and the second agent of Reference Example 1b. The oxidative hair dyes of Reference Examples 1a and 1b had a pH of 9.0 or more and 10.0 or less, and had a cream-like dosage form.

First agents of Reference Examples 1a and 1b The cream-like first agents of Reference Examples 1a and 1b having a pH of 9.0 or more and 10.0 or less and a viscosity of 40000 mPa s or more and 50000 mPa s or less were It was prepared by blending water and each component. Its ingredients are sodium cocoamphoacetate, oxidation dyes, cetostearyl alcohol, oleyl alcohol, polyoxyethylene alkyl ether, dicetyl phosphate, polyoxyethylene alkyl ether phosphate, PEG (20), hydrogenated oil, palm kernel oil, palm oil. , dextrin, xanthan gum, propylene glycol, anti-inflammatory agent, antioxidant, chelating agent, ammonium bicarbonate, aqueous ammonia and fragrance, and the blending amounts were as shown in Table 2-1 below.

Second Agents of Reference Examples 1a and 1b Cream-like second agents of Reference Examples 1a and 1b having a pH of 2.5 or more and 3.5 or less and a viscosity of 5000 mPa s or more and 10000 mPa s or less were mixed with water. It was prepared by blending each component. Its ingredients are hydrogen peroxide, cetostearyl alcohol, polyoxyethylene alkyl ether, polyoxyethylene alkyl ether phosphate, dicetyl phosphate, dimethyldiallylammonium chloride/acrylic acid copolymer liquid, chelating agent, phenoxyethanol, phosphoric acid and arginine. Yes, and the blending amounts were as shown in Table 2-2 below.

Table 2-3 below shows the evaluation results of Reference Examples 1a to 1b.

In Table 2-3, it can be confirmed that Reference Example 1a containing the component (A) was superior to Reference Example 1b in terms of "evaluation of suppression of skin irritation". This indicates that the inclusion of component (A) enhances the "skin irritation suppression evaluation."

Separately from the oxidative hair dyes of the above Examples and Reference Examples, the oxidative hair dyes of Reference Examples 2a and 2b were produced and evaluated for suppression of skin irritation in the same manner as in Example 1a. Details are as follows.

(Oxidative hair dyes of Reference Examples 2a to 2b)
The first agent of Reference Example 2a and the second agent of Reference Example 2a below were mixed at a mass ratio of 1:1 to obtain an oxidation hair dye of Reference Example 2a. Similarly, a mixture of the first agent of Reference Example 2b and the second agent of Reference Example 2b was used as the oxidation hair dye of Reference Example 2b. The oxidative hair dyes of Reference Examples 2a and 2b had a pH of 9.0 or more and 10.0 or less and had a cream-like dosage form.

First agent of Reference Examples 2a and 2b The cream-like first agent of Reference Examples 2a and 2b having a pH of 9.0 or more and 10.0 or less and a viscosity of 40000 mPa s or more and 50000 mPa s or less was mixed with water. It was prepared by blending each component. Its ingredients are sodium cocoamphoacetate, lauramidopropyl betaine, oxidation dye, cetostearyl alcohol, polyoxyethylene alkyl ether, glycol stearate, quaternary ammonium salt, PEG (20), liquid paraffin, hydrogenated oil, rice bran oil, Palm kernel oil, palm oil, dextrin, propylene glycol, isopropyl alcohol, anti-inflammatory agent, antioxidant, chelating agent, ammonium bicarbonate, aqueous ammonia and perfume, and the blending amounts were as shown in Table 3-1 below. .

Second Agents of Reference Examples 2a and 2b Cream-like second agents of Reference Examples 2a and 2b having a pH of 2.5 or more and 3.5 or less and a viscosity of 5000 mPa s or more and 10000 mPa s or less were mixed with water. It was prepared by blending each component. Its ingredients are sodium cocoamphoacetate, cocamidopropyl betaine, hydrogen peroxide, cetostearyl alcohol, polyoxyethylene alkyl ether, quaternary ammonium salt, liquid paraffin, bleached beeswax, soft lanolin fatty acid cholesteryl, chelating agent and phenoxyethanol, The blending amounts were as shown in Table 3-2 below.

Table 2-3 below shows the evaluation results of Reference Examples 2a and 2b.

In Table 3-3, it can be confirmed that Reference Example 2a containing the component (A) was superior to Reference Example 2b in the "skin irritation suppression evaluation". This indicates that the inclusion of component (A) enhances the "skin irritation suppression evaluation."

Separately from the oxidative hair dyes of the above Examples and Reference Examples, oxidative hair dyes of Reference Examples 3a to 3j were produced and evaluated for suppression of skin irritation in the same manner as in Example 1a. Details are as follows. The oxidative hair dyes of Reference Examples 3a to 3j had a pH of 9.0 or more and 10.0 or less and were cream-like in formulation.

(Oxidative hair dyes of Reference Examples 3a to 3j)
The first agent of Reference Example 3a and the second agent of Reference Example 3a below were mixed at a mass ratio of 1:1 to obtain an oxidative hair dye of Reference Example 3a. Similarly, the first agents of Reference Examples 3b to 3j and the second agents of Reference Examples 3b to 3j were mixed to obtain oxidative hair dyes of Reference Examples 3b to 3j.

First agents of Reference Examples 3a to 3j Cream-like first agents of Reference Examples 3a to 3j having a pH of 9.0 or more and 10.0 or less and a viscosity of 40000 mPa s or more and 50000 mPa s or less were mixed with water and each component. Manufactured by blending Its ingredients are meadowfoam oil, persic oil, olive oil, vegetable squalane (derived from olive), vegetable squalane (derived from sugarcane), shea butter (solid), shea butter (liquid), rice bran oil, castor oil, oxidized Dye, cetostearyl alcohol, polyoxyethylene alkyl ether, quaternary ammonium salt, PEG (20), isopropyl alcohol, antioxidant, chelating agent, ammonium bicarbonate, aqueous ammonia, and fragrance. -1.

Second agents of Reference Examples 3a to 3j Cream-like second agents of Reference Examples 3a to 3j having a pH of 2.5 or more and 3.5 or less and a viscosity of 5000 mPa s or more and 10000 mPa s or less were mixed with water and each component. Manufactured by blending Its ingredients are sodium cocoamphoacetate, hydrogen peroxide, cetostearyl alcohol, polyoxyethylene alkyl ether, quaternary ammonium salt, liquid paraffin, bleached beeswax, soft lanolin fatty acid cholesteryl, chelating agent and phenoxyethanol. As shown in Table 4-2.

Table 4-3 below shows the evaluation results of Reference Examples 2a and 2b.

In Table 4-3, Reference Examples 3b to 3e containing components (A) and (B) were superior to Reference Example 3a containing component (A) in terms of "evaluation of suppression of skin irritation". (Evaluation of Reference Example 3b containing meadowfoam oil was particularly excellent.). This indicates that the addition of the component (B) enhances the "skin irritation suppression evaluation." On the other hand, it can be confirmed that Reference Examples 3f to 3j, in which the comparative component (B) was blended, were inferior to Reference Example 3a.

Claims (3)

The following components (A), (B), (C) and (D) are blended ,
An oxidative hair dye or hair bleaching agent characterized by being liquid, creamy, waxy or gel .
(A) alkaline agent (B) oxidizing agent (C) N-acylaminoethyl-N-2-hydroxyethylglycine or N-acylaminoethyl-N-2-hydroxyethylglycine salt
(D) one or more selected from meadowfoam oil, persic oil, olive oil and olive oil-derived vegetable squalane An oxidative hair dye kit or hair bleach kit for obtaining the oxidative hair dye or hair bleach according to claim 1,
a first agent containing the component (A), and the component (C) and/or the component (D);
a second agent containing the component (B) and the component (C) and/or the component (D);
An oxidative hair dye kit or a hair bleaching kit, comprising: A method of oxidative hair dyeing or hair bleaching, characterized by using the oxidative hair dye or hair bleaching agent according to claim 1 .